Details for: COMMD9

Gene ID: 29099

Symbol: COMMD9

Ensembl ID: ENSG00000110442

Description: COMM domain containing 9

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 130.0265
    Cell Significance Index: -20.2300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 67.5752
    Cell Significance Index: -17.1400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 60.7116
    Cell Significance Index: -25.0100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 56.0236
    Cell Significance Index: -22.7600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 55.2293
    Cell Significance Index: -26.0800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 49.1460
    Cell Significance Index: -25.2800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 38.8661
    Cell Significance Index: -26.0800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 24.0588
    Cell Significance Index: -22.9700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 19.2992
    Cell Significance Index: -23.8000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.7384
    Cell Significance Index: -20.7300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.2696
    Cell Significance Index: -24.7400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.9586
    Cell Significance Index: -15.2300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.5633
    Cell Significance Index: -5.6100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.3382
    Cell Significance Index: 80.3400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.2274
    Cell Significance Index: 133.5100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.0036
    Cell Significance Index: 18.5500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.9850
    Cell Significance Index: 63.5500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9828
    Cell Significance Index: 159.8500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.6395
    Cell Significance Index: 33.3100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.5824
    Cell Significance Index: 4.6500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.5733
    Cell Significance Index: 15.3400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5675
    Cell Significance Index: 309.9500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4276
    Cell Significance Index: 14.8600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4113
    Cell Significance Index: 56.4800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4039
    Cell Significance Index: 27.9400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3853
    Cell Significance Index: 77.3000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3748
    Cell Significance Index: 23.6200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.3706
    Cell Significance Index: 19.4600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3701
    Cell Significance Index: 36.6100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.3506
    Cell Significance Index: 9.2200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3288
    Cell Significance Index: 59.2800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3219
    Cell Significance Index: 15.0100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.3159
    Cell Significance Index: 4.3100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3014
    Cell Significance Index: 208.4500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.2905
    Cell Significance Index: 6.0800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2874
    Cell Significance Index: 7.7000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2692
    Cell Significance Index: 119.0000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2567
    Cell Significance Index: 31.5600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2553
    Cell Significance Index: 30.1100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2229
    Cell Significance Index: 11.5800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2156
    Cell Significance Index: 4.6700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1865
    Cell Significance Index: 35.4900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1834
    Cell Significance Index: 65.7700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1717
    Cell Significance Index: 22.1800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1477
    Cell Significance Index: 4.2600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1428
    Cell Significance Index: 6.7100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1423
    Cell Significance Index: 6.4500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1250
    Cell Significance Index: 21.3500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1237
    Cell Significance Index: 24.5400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1155
    Cell Significance Index: 8.1700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1119
    Cell Significance Index: 14.3500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0943
    Cell Significance Index: 2.7700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0407
    Cell Significance Index: 3.0300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0342
    Cell Significance Index: 1.2000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0112
    Cell Significance Index: 0.3000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0043
    Cell Significance Index: 3.1800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0041
    Cell Significance Index: 3.0800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0017
    Cell Significance Index: -3.2300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0057
    Cell Significance Index: -10.5300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0066
    Cell Significance Index: -0.6700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0068
    Cell Significance Index: -5.0500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0106
    Cell Significance Index: -14.4800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0115
    Cell Significance Index: -7.1800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0116
    Cell Significance Index: -17.7900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0239
    Cell Significance Index: -15.2100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0272
    Cell Significance Index: -0.7600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0276
    Cell Significance Index: -0.3000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0292
    Cell Significance Index: -16.4400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0323
    Cell Significance Index: -0.5400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0428
    Cell Significance Index: -19.4300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0488
    Cell Significance Index: -10.2700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0555
    Cell Significance Index: -6.3600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0655
    Cell Significance Index: -18.8600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0842
    Cell Significance Index: -2.1500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0919
    Cell Significance Index: -5.6500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1229
    Cell Significance Index: -17.8700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1236
    Cell Significance Index: -14.4000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1267
    Cell Significance Index: -14.4600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1422
    Cell Significance Index: -7.9800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1594
    Cell Significance Index: -1.9000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1708
    Cell Significance Index: -13.1100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1961
    Cell Significance Index: -3.3600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1985
    Cell Significance Index: -13.3500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2141
    Cell Significance Index: -4.5600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2158
    Cell Significance Index: -17.0900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2299
    Cell Significance Index: -23.9400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2306
    Cell Significance Index: -2.6200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3151
    Cell Significance Index: -8.1000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3382
    Cell Significance Index: -9.9600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3453
    Cell Significance Index: -11.0600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3470
    Cell Significance Index: -9.4500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3696
    Cell Significance Index: -16.3500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.3952
    Cell Significance Index: -3.3200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.4149
    Cell Significance Index: -4.3000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4205
    Cell Significance Index: -25.7800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4283
    Cell Significance Index: -16.2200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5009
    Cell Significance Index: -14.3600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.5295
    Cell Significance Index: -11.6000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5299
    Cell Significance Index: -17.3500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5329
    Cell Significance Index: -18.6700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** COMMD9 is widely expressed across various cell types, including immune cells (e.g., monocytes, dendritic cells), hematopoietic progenitor cells, and epithelial cells. 2. **Protein Structure:** The COMMD9 protein contains a unique COMM domain, which is characterized by a conserved arrangement of cysteine and aspartic acid residues. 3. **Signaling Pathways:** COMMD9 is involved in multiple signaling pathways, including those regulating cholesterol homeostasis, innate immunity, and protein modification. 4. **Subcellular Localization:** COMMD9 is primarily localized to the Golgi apparatus, endoplasmic reticulum, and cytosol. **Pathways and Functions:** 1. **Cholesterol Homeostasis:** COMMD9 regulates cholesterol homeostasis by modulating the activity of enzymes involved in cholesterol synthesis and degradation. 2. **Innate Immunity:** COMMD9 plays a crucial role in regulating innate immune responses, particularly in the context of neutrophil degranulation and the formation of ficolin-1-rich granules. 3. **Protein Modification:** COMMD9 is involved in the regulation of protein modification, including neddylation and post-translational protein modification. 4. **Cellular Homeostasis:** COMMD9 helps maintain cellular homeostasis by regulating the activity of enzymes involved in protein metabolism and protein degradation. **Clinical Significance:** 1. **Immune-Related Disorders:** COMMD9 has been implicated in the pathogenesis of immune-related disorders, including autoimmune diseases and inflammatory conditions. 2. **Protein Misfolding Diseases:** COMMD9 may play a role in the regulation of protein misfolding and aggregation, which is a hallmark of various protein misfolding diseases. 3. **Cancer:** COMMD9 has been shown to be overexpressed in certain types of cancer, suggesting its potential role in tumorigenesis and cancer progression. 4. **Therapeutic Targets:** COMMD9 represents a potential therapeutic target for the treatment of immune-related disorders and diseases characterized by protein misfolding. In conclusion, COMMD9 is a gene with a complex and multifaceted role in regulating various cellular processes, including immune responses, protein metabolism, and cellular homeostasis. Further research is needed to fully elucidate the mechanisms by which COMMD9 functions and to explore its potential as a therapeutic target for the treatment of immune-related disorders and diseases characterized by protein misfolding.

Genular Protein ID: 3330441405

Symbol: COMD9_HUMAN

Name: COMM domain-containing protein 9

UniProtKB Accession Codes:

Q9P000 E9PAN2 Q96FI2 Q9H0R0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 EMDB 4 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 8 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 7 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15799966

Title: COMMD proteins, a novel family of structural and functional homologs of MURR1.

PubMed ID: 15799966

DOI: 10.1074/jbc.m501928200

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21778237

Title: COMMD1 (copper metabolism MURR1 domain-containing protein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Nedd8-dissociated protein 1) binding.

PubMed ID: 21778237

DOI: 10.1074/jbc.m111.278408

PubMed ID: 23637203

Title: Functional interaction of COMMD3 and COMMD9 with the epithelial sodium channel.

PubMed ID: 23637203

DOI: 10.1152/ajprenal.00158.2013

PubMed ID: 23563313

Title: CCDC22 deficiency in humans blunts activation of proinflammatory NF-kappaB signaling.

PubMed ID: 23563313

DOI: 10.1172/jci66466

PubMed ID: 25355947

Title: COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A.

PubMed ID: 25355947

DOI: 10.1091/mbc.e14-06-1073

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28892079

Title: Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling.

PubMed ID: 28892079

DOI: 10.1038/ncb3610

Sequence Information:

  • Length: 198
  • Mass: 21819
  • Checksum: 54DA2FE525C3A24F
  • Sequence:
    • MAALTAEHFA ALQSLLKASS KDVVRQLCQE SFSSSALGLK KLLDVTCSSL SVTQEEAEEL 
LQALHRLTRL VAFRDLSSAE AILALFPENF HQNLKNLLTK IILEHVSTWR TEAQANQISL 
PRLVDLDWRV DIKTSSDSIS RMAVPTCLLQ MKIQEDPSLC GDKPSISAVT VELSKETLDT 
MLDGLGRIRD QLSAVASK

Genular Protein ID: 4097971879

Symbol: E9PJ95_HUMAN

Name: N/A

UniProtKB Accession Codes:

E9PJ95

Database IDs:

AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 2 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 2 Pfam 2 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 1 SMR 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 185
  • Mass: 20688
  • Checksum: E9D4CA9E477D90C8
  • Sequence:
    • MAALTAEHFA ALQSLLKASS KDVVRQLCQE SFSSSALGLK KLLDVTCSSL SVTQEEAEEL 
LQALHRLTRL VAFRDLSSAE AILALFPENF HQNLKNLLTK IILEHVLSAT PGRSGLESGY 
QNLLRQHQPH GRPHLPAPDE DPRRSQPMRR QTLHLSCHRG AEQRNTGHHV RWPGPHPRPT 
LCRGQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.