Details for: MET

Gene ID: 4233

Symbol: MET

Ensembl ID: ENSG00000105976

Description: MET proto-oncogene, receptor tyrosine kinase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 52.2083
    Cell Significance Index: -21.2100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 22.1211
    Cell Significance Index: -21.1200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.6305
    Cell Significance Index: -16.7000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.5787
    Cell Significance Index: 70.1900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.5785
    Cell Significance Index: 68.8500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.7283
    Cell Significance Index: 342.9800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.5756
    Cell Significance Index: 108.9600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.5610
    Cell Significance Index: 26.3000
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.3140
    Cell Significance Index: 22.1000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.2609
    Cell Significance Index: 65.5000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0404
    Cell Significance Index: 939.4000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.0070
    Cell Significance Index: 29.0200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.9493
    Cell Significance Index: 518.4200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.8908
    Cell Significance Index: 19.3000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8490
    Cell Significance Index: 50.9700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.8209
    Cell Significance Index: 21.1000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8147
    Cell Significance Index: 88.6200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7750
    Cell Significance Index: 35.1300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7326
    Cell Significance Index: 119.1500
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.6282
    Cell Significance Index: 6.4800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.5652
    Cell Significance Index: 43.3800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.5275
    Cell Significance Index: 12.8700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5166
    Cell Significance Index: 63.5200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.4665
    Cell Significance Index: 11.6600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.4508
    Cell Significance Index: 848.8500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.3795
    Cell Significance Index: 10.8300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3759
    Cell Significance Index: 37.1800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2997
    Cell Significance Index: 10.5300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2484
    Cell Significance Index: 44.7800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2028
    Cell Significance Index: 4.3200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1720
    Cell Significance Index: 109.2400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1635
    Cell Significance Index: 251.7400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1565
    Cell Significance Index: 26.7300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1472
    Cell Significance Index: 7.6700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1469
    Cell Significance Index: 270.9000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1306
    Cell Significance Index: 57.7300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1080
    Cell Significance Index: 21.6700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0930
    Cell Significance Index: 126.3900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0764
    Cell Significance Index: 14.5500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0416
    Cell Significance Index: 25.9500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0268
    Cell Significance Index: 0.7500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0207
    Cell Significance Index: 15.6500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0199
    Cell Significance Index: 2.5700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0051
    Cell Significance Index: 0.6500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0027
    Cell Significance Index: -2.0000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0081
    Cell Significance Index: -1.1800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0091
    Cell Significance Index: -6.7200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0169
    Cell Significance Index: -11.6800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0200
    Cell Significance Index: -2.2800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0251
    Cell Significance Index: -14.1800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0263
    Cell Significance Index: -2.6900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0293
    Cell Significance Index: -0.4000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0371
    Cell Significance Index: -13.3200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0392
    Cell Significance Index: -17.8000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0482
    Cell Significance Index: -1.0000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0517
    Cell Significance Index: -10.8800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0649
    Cell Significance Index: -18.6800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0701
    Cell Significance Index: -7.3000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0776
    Cell Significance Index: -8.8900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0827
    Cell Significance Index: -1.2200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0998
    Cell Significance Index: -11.6300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1051
    Cell Significance Index: -7.4300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1118
    Cell Significance Index: -13.1800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1151
    Cell Significance Index: -5.4100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1211
    Cell Significance Index: -16.6400
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.1512
    Cell Significance Index: -2.4400
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.1633
    Cell Significance Index: -2.3300
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.1849
    Cell Significance Index: -1.9300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1881
    Cell Significance Index: -8.7700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2213
    Cell Significance Index: -13.5700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2255
    Cell Significance Index: -16.8100
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.2303
    Cell Significance Index: -2.0800
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.2494
    Cell Significance Index: -3.4600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2780
    Cell Significance Index: -22.0200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2802
    Cell Significance Index: -5.9900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2915
    Cell Significance Index: -7.6700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2926
    Cell Significance Index: -4.4100
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.3257
    Cell Significance Index: -3.4600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3481
    Cell Significance Index: -19.5400
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.3493
    Cell Significance Index: -2.6700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3538
    Cell Significance Index: -23.7900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3653
    Cell Significance Index: -11.7000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3875
    Cell Significance Index: -23.8200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4239
    Cell Significance Index: -26.7200
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.4664
    Cell Significance Index: -14.7500
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.4714
    Cell Significance Index: -6.0900
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.4775
    Cell Significance Index: -2.9600
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.4813
    Cell Significance Index: -4.5100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.5175
    Cell Significance Index: -26.1600
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.5205
    Cell Significance Index: -4.6200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5230
    Cell Significance Index: -19.2000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5286
    Cell Significance Index: -15.5700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.5317
    Cell Significance Index: -6.0400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.5332
    Cell Significance Index: -4.9100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5344
    Cell Significance Index: -28.0600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5525
    Cell Significance Index: -19.2000
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.5611
    Cell Significance Index: -8.0700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5625
    Cell Significance Index: -24.8800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.5643
    Cell Significance Index: -8.7300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.6129
    Cell Significance Index: -10.8300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The MET proto-oncogene has several key characteristics that distinguish it from other receptors: 1. **Receptor Tyrosine Kinase (RTK) Activity**: The MET protein is a RTK that undergoes autophosphorylation upon binding to HGF, activating downstream signaling pathways. 2. **Ligand-Dependent Activation**: The MET protein is activated by its ligand, hepatocyte growth factor (HGF), which binds to the MET protein and triggers autophosphorylation. 3. **Tissue-Specific Expression**: The MET gene is significantly expressed in various tissues, including the liver, kidneys, lungs, and brain. 4. **Disease Association**: The MET gene is involved in various diseases, including cancer, fibrosis, and inflammatory disorders. **Pathways and Functions** The MET proto-oncogene is involved in several signaling pathways, including: 1. **PI3K/AKT Signaling**: The MET protein activates the PI3K/AKT signaling pathway, which regulates cell survival, proliferation, and migration. 2. **MAPK/ERK Signaling**: The MET protein activates the MAPK/ERK signaling pathway, which regulates cell proliferation, differentiation, and migration. 3. **RAS Signaling**: The MET protein activates the RAS signaling pathway, which regulates cell proliferation, differentiation, and migration. 4. **Angiogenesis**: The MET protein regulates angiogenesis, the process of new blood vessel formation, which is essential for tumor growth and metastasis. The MET protein also regulates various cellular functions, including: 1. **Cell Growth and Proliferation**: The MET protein regulates cell growth and proliferation by activating the PI3K/AKT and MAPK/ERK signaling pathways. 2. **Cell Migration**: The MET protein regulates cell migration by activating the PI3K/AKT and RAS signaling pathways. 3. **Cell Differentiation**: The MET protein regulates cell differentiation by activating the MAPK/ERK signaling pathway. 4. **Angiogenesis**: The MET protein regulates angiogenesis by activating the PI3K/AKT signaling pathway. **Clinical Significance** The MET proto-oncogene is involved in various diseases, including: 1. **Cancer**: The MET gene is overexpressed in various types of cancer, including breast, lung, and liver cancer. 2. **Fibrosis**: The MET gene is involved in the development of fibrosis, a condition characterized by excessive scar tissue formation. 3. **Inflammatory Disorders**: The MET gene is involved in the development of inflammatory disorders, such as rheumatoid arthritis and atherosclerosis. 4. **Neurological Disorders**: The MET gene is involved in the development of neurological disorders, such as Parkinson's disease and Alzheimer's disease. Targeting the MET proto-oncogene has been explored as a therapeutic strategy for various diseases, including cancer and fibrosis. Small molecule inhibitors, such as MET inhibitors, have been developed to block MET signaling and inhibit tumor growth and metastasis.

Genular Protein ID: 3012852354

Symbol: MET_HUMAN

Name: Hepatocyte growth factor receptor

UniProtKB Accession Codes:

P08581 A1L467 B5A932 E7EQ94 O60366 Q12875 Q9UDX7 Q9UPL8

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 6 CORUM 1 CPTAC 3 CPTC 1 CTD 1 ChEBI 7 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 20 DrugCentral 1 EC 2 ELM 1 EMBL 11 EMDB 5 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 37 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 16 KEGG 1 MANE-Select 1 MIM 11 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 Orphanet 5 OrthoDB 1 PANTHER 2 PDB 100 PDBsum 100 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 19 RefSeq 2 Rhea 3 SASBDB 1 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 2 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2819873

Title: Sequence of MET protooncogene cDNA has features characteristic of the tyrosine kinase family of growth-factor receptors.

PubMed ID: 2819873

DOI: 10.1073/pnas.84.18.6379

PubMed ID: 18593464

Title: Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis.

PubMed ID: 18593464

DOI: 10.1186/ar2447

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3325883

Title: Primary structure of the met protein tyrosine kinase domain.

PubMed ID: 3325883

PubMed ID: 8247543

Title: A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes.

PubMed ID: 8247543

PubMed ID: 4069211

Title: The human met oncogene is related to the tyrosine kinase oncogenes.

PubMed ID: 4069211

DOI: 10.1038/318385a0

PubMed ID: 1917129

Title: The receptor encoded by the human c-MET oncogene is expressed in hepatocytes, epithelial cells and solid tumors.

PubMed ID: 1917129

DOI: 10.1002/ijc.2910490302

PubMed ID: 1718989

Title: The tyrosine-phosphorylated hepatocyte growth factor/scatter factor receptor associates with phosphatidylinositol 3-kinase.

PubMed ID: 1718989

DOI: 10.1016/s0021-9258(18)54536-1

PubMed ID: 1719465

Title: Expression of the Met/HGF receptor in normal and neoplastic human tissues.

PubMed ID: 1719465

PubMed ID: 1846706

Title: Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product.

PubMed ID: 1846706

DOI: 10.1126/science.1846706

PubMed ID: 1655790

Title: Identification of the major autophosphorylation site of the Met/hepatocyte growth factor receptor tyrosine kinase.

PubMed ID: 1655790

DOI: 10.1016/s0021-9258(18)55031-6

PubMed ID: 7513258

Title: A multifunctional docking site mediates signaling and transformation by the hepatocyte growth factor/scatter factor receptor family.

PubMed ID: 7513258

DOI: 10.1016/0092-8674(94)90318-2

PubMed ID: 8182137

Title: Hepatocyte growth factor/scatter factor effects on epithelia. Regulation of intercellular junctions in transformed and nontransformed cell lines, basolateral polarization of c-met receptor in transformed and natural intestinal epithelia, and induction of rapid wound repair in a transformed model epithelium.

PubMed ID: 8182137

DOI: 10.1172/jci117200

PubMed ID: 9440692

Title: Induction of epithelial tubules by growth factor HGF depends on the STAT pathway.

PubMed ID: 9440692

DOI: 10.1038/34657

PubMed ID: 10454568

Title: Grb10, a positive, stimulatory signaling adapter in platelet-derived growth factor BB-, insulin-like growth factor I-, and insulin-mediated mitogenesis.

PubMed ID: 10454568

DOI: 10.1128/mcb.19.9.6217

PubMed ID: 11081636

Title: InIB-dependent internalization of Listeria is mediated by the Met receptor tyrosine kinase.

PubMed ID: 11081636

DOI: 10.1016/s0092-8674(00)00141-0

PubMed ID: 12147692

Title: Activation of Ras/Erk pathway by a novel MET-interacting protein RanBPM.

PubMed ID: 12147692

DOI: 10.1074/jbc.m205111200

PubMed ID: 12244174

Title: c-Cbl is involved in Met signaling in B cells and mediates hepatocyte growth factor-induced receptor ubiquitination.

PubMed ID: 12244174

DOI: 10.4049/jimmunol.169.7.3793

PubMed ID: 12198496

Title: The semaphorin 4D receptor controls invasive growth by coupling with Met.

PubMed ID: 12198496

DOI: 10.1038/ncb843

PubMed ID: 12475979

Title: Hepatocyte growth factor receptor tyrosine kinase met is a substrate of the receptor protein-tyrosine phosphatase DEP-1.

PubMed ID: 12475979

DOI: 10.1074/jbc.m210656200

PubMed ID: 14684163

Title: A novel MET-interacting protein shares high sequence similarity with RanBPM, but fails to stimulate MET-induced Ras/Erk signaling.

PubMed ID: 14684163

DOI: 10.1016/j.bbrc.2003.11.124

PubMed ID: 15314156

Title: MUC20 suppresses the hepatocyte growth factor-induced Grb2-Ras pathway by binding to a multifunctional docking site of met.

PubMed ID: 15314156

DOI: 10.1128/mcb.24.17.7456-7468.2004

PubMed ID: 15735664

Title: The SH2-domain-containing inositol 5-phosphatase (SHIP)-2 binds to c-Met directly via tyrosine residue 1356 and involves hepatocyte growth factor (HGF)-induced lamellipodium formation, cell scattering and cell spreading.

PubMed ID: 15735664

DOI: 10.1038/sj.onc.1208558

PubMed ID: 16862193

Title: Invasive growth: a MET-driven genetic programme for cancer and stem cells.

PubMed ID: 16862193

DOI: 10.1038/nrc1912

PubMed ID: 18819921

Title: Regulation of the Met receptor-tyrosine kinase by the protein-tyrosine phosphatase 1B and T-cell phosphatase.

PubMed ID: 18819921

DOI: 10.1074/jbc.m805916200

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19196183

Title: Identification of N-glycosylation sites on secreted proteins of human hepatocellular carcinoma cells with a complementary proteomics approach.

PubMed ID: 19196183

DOI: 10.1021/pr800826u

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20655987

Title: The HGF/MET pathway as target for the treatment of multiple myeloma and B-cell lymphomas.

PubMed ID: 20655987

DOI: 10.1016/j.bbcan.2010.07.006

PubMed ID: 19900460

Title: Ligand-mediated dimerization of the Met receptor tyrosine kinase by the bacterial invasion protein InlB.

PubMed ID: 19900460

DOI: 10.1016/j.jmb.2009.10.074

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21784853

Title: Distinct involvement of the Gab1 and Grb2 adaptor proteins in signal transduction by the related receptor tyrosine kinases RON and MET.

PubMed ID: 21784853

DOI: 10.1074/jbc.m111.239384

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24814316

Title: Tensin-4-dependent MET stabilization is essential for survival and proliferation in carcinoma cells.

PubMed ID: 24814316

DOI: 10.1016/j.devcel.2014.03.024

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26637977

Title: Mutations preventing regulated exon skipping in MET cause osteofibrous dysplasia.

PubMed ID: 26637977

DOI: 10.1016/j.ajhg.2015.11.001

PubMed ID: 25941349

Title: A mutation of MET, encoding hepatocyte growth factor receptor, is associated with human DFNB97 hearing loss.

PubMed ID: 25941349

DOI: 10.1136/jmedgenet-2015-103023

PubMed ID: 26517842

Title: Client proteins and small molecule inhibitors display distinct binding preferences for constitutive and stress-induced HSP90 isoforms and their conformationally restricted mutants.

PubMed ID: 26517842

DOI: 10.1371/journal.pone.0141786

PubMed ID: 27334921

Title: Crystal structure of human leukocyte cell-derived chemotaxin 2 (LECT2) reveals a mechanistic basis of functional evolution in a mammalian protein with an M23 metalloendopeptidase fold.

PubMed ID: 27334921

DOI: 10.1074/jbc.m116.720375

PubMed ID: 37186866

Title: The SHDRA syndrome-associated geDne TMEM260 encodes a protein-specific O-mannosyltransferase.

PubMed ID: 37186866

DOI: 10.1073/pnas.2302584120

PubMed ID: 11063574

Title: Dimer formation through domain swapping in the crystal structure of the Grb2-SH2-Ac-pYVNV complex.

PubMed ID: 11063574

DOI: 10.1021/bi0012336

PubMed ID: 14559966

Title: Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met and its complex with the microbial alkaloid K-252a.

PubMed ID: 14559966

DOI: 10.1073/pnas.1734128100

PubMed ID: 15358240

Title: Insights into function of PSI domains from structure of the Met receptor PSI domain.

PubMed ID: 15358240

DOI: 10.1016/j.bbrc.2004.06.132

PubMed ID: 15167892

Title: Crystal structure of the HGF beta-chain in complex with the Sema domain of the Met receptor.

PubMed ID: 15167892

DOI: 10.1038/sj.emboj.7600243

PubMed ID: 17662939

Title: Structure of the human receptor tyrosine kinase Met in complex with the Listeria invasion protein InlB.

PubMed ID: 17662939

DOI: 10.1016/j.cell.2007.05.037

PubMed ID: 9140397

Title: Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas.

PubMed ID: 9140397

DOI: 10.1038/ng0597-68

PubMed ID: 9563489

Title: Two North American families with hereditary papillary renal carcinoma and identical novel mutations in the MET proto-oncogene.

PubMed ID: 9563489

PubMed ID: 10433944

Title: Hereditary and sporadic papillary renal carcinomas with c-met mutations share a distinct morphological phenotype.

PubMed ID: 10433944

DOI: 10.1016/s0002-9440(10)65147-4

PubMed ID: 9927037

Title: Somatic mutations in the kinase domain of the Met/hepatocyte growth factor receptor gene in childhood hepatocellular carcinomas.

PubMed ID: 9927037

PubMed ID: 10417759

Title: Novel mutation in the ATP-binding site of the MET oncogene tyrosine kinase in a HPRCC family.

PubMed ID: 10417759

DOI: 10.1002/(sici)1097-0215(19990827)82:5<640::aid-ijc4>3.0.co;2-6

PubMed ID: 10327054

Title: Novel mutations of the MET proto-oncogene in papillary renal carcinomas.

PubMed ID: 10327054

DOI: 10.1038/sj.onc.1202547

PubMed ID: 11042681

Title: A novel germ line juxtamembrane Met mutation in human gastric cancer.

PubMed ID: 11042681

DOI: 10.1038/sj.onc.1203874

PubMed ID: 12920089

Title: A novel germline mutation in the MET extracellular domain in a Korean patient with the diffuse type of familial gastric cancer.

PubMed ID: 12920089

DOI: 10.1136/jmg.40.8.e97

PubMed ID: 15713673

Title: The SPRY domain-containing SOCS box protein 1 (SSB-1) interacts with MET and enhances the hepatocyte growth factor-induced Erk-Elk-1-serum response element pathway.

PubMed ID: 15713673

DOI: 10.1074/jbc.m413897200

PubMed ID: 17053076

Title: A genetic variant that disrupts MET transcription is associated with autism.

PubMed ID: 17053076

DOI: 10.1073/pnas.0605296103

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 20949619

Title: MET mutations in cancers of unknown primary origin (CUPs).

PubMed ID: 20949619

DOI: 10.1002/humu.21374

PubMed ID: 28294470

Title: Exome sequencing deciphers a germline MET mutation in familial epidermal growth factor receptor-mutant lung cancer.

PubMed ID: 28294470

DOI: 10.1111/cas.13233

PubMed ID: 30777867

Title: MET mutation causes muscular dysplasia and arthrogryposis.

PubMed ID: 30777867

DOI: 10.15252/emmm.201809709

Sequence Information:

  • Length: 1390
  • Mass: 155541
  • Checksum: 9CF896D1273905C3
  • Sequence:
    • MKAPAVLAPG ILVLLFTLVQ RSNGECKEAL AKSEMNVNMK YQLPNFTAET PIQNVILHEH 
HIFLGATNYI YVLNEEDLQK VAEYKTGPVL EHPDCFPCQD CSSKANLSGG VWKDNINMAL 
VVDTYYDDQL ISCGSVNRGT CQRHVFPHNH TADIQSEVHC IFSPQIEEPS QCPDCVVSAL 
GAKVLSSVKD RFINFFVGNT INSSYFPDHP LHSISVRRLK ETKDGFMFLT DQSYIDVLPE 
FRDSYPIKYV HAFESNNFIY FLTVQRETLD AQTFHTRIIR FCSINSGLHS YMEMPLECIL 
TEKRKKRSTK KEVFNILQAA YVSKPGAQLA RQIGASLNDD ILFGVFAQSK PDSAEPMDRS 
AMCAFPIKYV NDFFNKIVNK NNVRCLQHFY GPNHEHCFNR TLLRNSSGCE ARRDEYRTEF 
TTALQRVDLF MGQFSEVLLT SISTFIKGDL TIANLGTSEG RFMQVVVSRS GPSTPHVNFL 
LDSHPVSPEV IVEHTLNQNG YTLVITGKKI TKIPLNGLGC RHFQSCSQCL SAPPFVQCGW 
CHDKCVRSEE CLSGTWTQQI CLPAIYKVFP NSAPLEGGTR LTICGWDFGF RRNNKFDLKK 
TRVLLGNESC TLTLSESTMN TLKCTVGPAM NKHFNMSIII SNGHGTTQYS TFSYVDPVIT 
SISPKYGPMA GGTLLTLTGN YLNSGNSRHI SIGGKTCTLK SVSNSILECY TPAQTISTEF 
AVKLKIDLAN RETSIFSYRE DPIVYEIHPT KSFISGGSTI TGVGKNLNSV SVPRMVINVH 
EAGRNFTVAC QHRSNSEIIC CTTPSLQQLN LQLPLKTKAF FMLDGILSKY FDLIYVHNPV 
FKPFEKPVMI SMGNENVLEI KGNDIDPEAV KGEVLKVGNK SCENIHLHSE AVLCTVPNDL 
LKLNSELNIE WKQAISSTVL GKVIVQPDQN FTGLIAGVVS ISTALLLLLG FFLWLKKRKQ 
IKDLGSELVR YDARVHTPHL DRLVSARSVS PTTEMVSNES VDYRATFPED QFPNSSQNGS 
CRQVQYPLTD MSPILTSGDS DISSPLLQNT VHIDLSALNP ELVQAVQHVV IGPSSLIVHF 
NEVIGRGHFG CVYHGTLLDN DGKKIHCAVK SLNRITDIGE VSQFLTEGII MKDFSHPNVL 
SLLGICLRSE GSPLVVLPYM KHGDLRNFIR NETHNPTVKD LIGFGLQVAK GMKYLASKKF 
VHRDLAARNC MLDEKFTVKV ADFGLARDMY DKEYYSVHNK TGAKLPVKWM ALESLQTQKF 
TTKSDVWSFG VLLWELMTRG APPYPDVNTF DITVYLLQGR RLLQPEYCPD PLYEVMLKCW 
HPKAEMRPSF SELVSRISAI FSTFIGEHYV HVNATYVNVK CVAPYPSLLS SEDNADDEVD 
TRPASFWETS

Genular Protein ID: 1985676815

Symbol: B4DLF5_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DLF5

Database IDs:

ARBA 13 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 4 CTD 1 ChEBI 6 DNASU 1 DisGeNET 1 EC 1 EMBL 2 GO 3 Gene3D 3 InterPro 15 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 6 PROSITE-ProRule 2 PeptideAtlas 1 Pfam 3 RefSeq 2 Rhea 3 SAM 1 SMART 3 SMR 1 SUPFAM 4

Sequence Information:

  • Length: 960
  • Mass: 106525
  • Checksum: 648AFCFBA543C6AB
  • Sequence:
    • MGQFSEVLLT SISTFIKGDL TIANLGTSEG RFMQVVVSRS GPSTPHVNFL LDSHPVSPEV 
IVEHTLNQNG YTLVITGKKI TKIPLNGLGC RHFQSCSQCL SAPPFVQCGW CHDKCVRSEE 
CLSGTWTQQI CLPAIYKVFP NSAPLEGGTR LTICGWDFGF RRNNKFDLKK TRVLLGNESC 
TLTLSESTMN TLKCTVGPAM NKHFNMSIII SNGHGTTQYS TFSYVDPVIT SISPKYGPMA 
GGTLLTLTGN YLNSGNSRHI SIGGKTCTLK SVSNSILECY TPAQTISTEF AVKLKIDLAN 
RETSIFSYRE DPIVYEIHPT KSFISGGSTI TGVGKNLNSV SVPRMVINVH EAGRNFTVAC 
QHRSNSEIIC CTTPSLQQLN LQLPLKTKAF FMLDGILSKY FDLIYVHNPV FKPFEKPVMI 
SMGNENVLEI KGNDIDPEAV KGEVLKVGNK SCENIHLHSE AVLCTVPNDL LKLNSELNIE 
WKQAISSTVL GKVIVQPDQN FTGLIAGVVS ISTALLLLLG FFLWLKKRKQ IKDLGSELVR 
YDARVHTPHL DRLVSARSVS PTTEMVSNES VDYRATFPED QFPNSSQNGS CRQVQYPLTD 
MSPILTSGDS DISSPLLQNT VHIDLSALNP ELVQAVQHVV IGPSSLIVHF NEVIGRGHFG 
CVYHGTLLDN DGKKIHCAVK SLNRITDIGE VSQFLTEGII MKDFSHPNVL SLLGICLRSE 
GSPLVVLPYM KHGDLRNFIR NETHNPTVKD LIGFGLQVAK GMKYLASKKF VHRDLAARNC 
MLDEKFTVKV ADFGLARDMY DKEYYSVHNK TGAKLPVKWM ALESLQTQKF TTKSDVWSFG 
VLLWELMTRG APPYPDVNTF DITVYLLQGR RLLQPEYCPD PLYEVMLKCW HPKAEMRPSF 
SELVSRISAI FSTFIGEHYV HVNATYVNVK CVAPYPSLLS SEDNADDEVD TRPASFWETS

Genular Protein ID: 3218730174

Symbol: E6Y365_HUMAN

Name: N/A

UniProtKB Accession Codes:

E6Y365 H7C174

Database IDs:

ARBA 6 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 4 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 2 GO 2 Gene3D 2 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 9 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 3 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 1 SMART 3 SUPFAM 3 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

Sequence Information:

  • Length: 934
  • Mass: 104286
  • Checksum: 726F6B14D496C41C
  • Sequence:
    • MKAPAVLAPG ILVLLFTLVQ RSNGECKEAL AKSEMNVNMK YQLPNFTAET PIQNVILHEH 
HIFLGATNYI YVLNEEDLQK VAEYKTGPVL EHPDCFPCQD CSSKANLSGG VWKDNINMAL 
VVDTYYDDQL ISCGSVNRGT CQRHVFPHNH TADIQSEVHC IFSPQIEEPS QCPDCVVSAL 
GAKVLSSVKD RFINFFVGNT INSSYFPDHP LHSISVRRLK ETKDGFMFLT DQSYIDVLPE 
FRDSYPIKYV HAFESNNFIY FLTVQRETLD AQTFHTRIIR FCSINSGLHS YMEMPLECIL 
TEKRKKRSTK KEVFNILQAA YVSKPGAQLA RQIGASLNDD ILFGVFAQSK PDSAEPMDRS 
AMCAFPIKYV NDFFNKIVNK NNVRCLQHFY GPNHEHCFNR TLLRNSSGCE ARRDEYRTEF 
TTALQRVDLF MGQFSEVLLT SISTFIKGDL TIANLGTSEG RFMQVVVSRS GPSTPHVNFL 
LDSHPVSPEV IVEHTLNQNG YTLVITGKKI TKIPLNGLGC RHFQSCSQCL SAPPFVQCGW 
CHDKCVRSEE CLSGTWTQQI CLPAIYKVFP NSAPLEGGTR LTICGWDFGF RRNNKFDLKK 
TRVLLGNESC TLTLSESTMN TLKCTVGPAM NKHFNMSIII SNGHGTTQYS TFSYVDPVIT 
SISPKYGPMA GGTLLTLTGN YLNSGNSRHI SIGGKTCTLK SVSNSILECY TPAQTISTEF 
AVKLKIDLAN RETSIFSYRE DPIVYEIHPT KSFISGGSTI TGVGKNLNSV SVPRMVINVH 
EAGRNFTVAC QHRSNSEIIC CTTPSLQQLN LQLPLKTKAF FMLDGILSKY FDLIYVHNPV 
FKPFEKPVMI SMGNENVLEI KGNDIDPEAV KGEVLKVGNK SCENIHLHSE AVLCTVPNDL 
LKLNSELNIE VGFLHSSHDV NKEASVIMLF SGLK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.