Details for: SHMT2

Gene ID: 6472

Symbol: SHMT2

Ensembl ID: ENSG00000182199

Description: serine hydroxymethyltransferase 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 109.1001
    Cell Significance Index: -16.9700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 53.7204
    Cell Significance Index: -22.1300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 53.1455
    Cell Significance Index: -13.4800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 50.9037
    Cell Significance Index: -20.6800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 47.0852
    Cell Significance Index: -22.2300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 45.5106
    Cell Significance Index: -23.4100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 33.0391
    Cell Significance Index: -22.1700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 21.9431
    Cell Significance Index: -20.9500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 16.4077
    Cell Significance Index: -20.2300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.8686
    Cell Significance Index: -18.4000
  • Cell Name: colon endothelial cell (CL1001572)
    Fold Change: 6.2630
    Cell Significance Index: 4.7800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.3598
    Cell Significance Index: -21.1500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.8934
    Cell Significance Index: -15.0300
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 3.1263
    Cell Significance Index: 15.2100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.8021
    Cell Significance Index: 108.1900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.7753
    Cell Significance Index: 19.3000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.5954
    Cell Significance Index: 173.5400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.5595
    Cell Significance Index: 45.8000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.3456
    Cell Significance Index: 158.6900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.2228
    Cell Significance Index: 32.7100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.9971
    Cell Significance Index: 12.7700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7806
    Cell Significance Index: 53.9800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.7344
    Cell Significance Index: 25.5200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7217
    Cell Significance Index: 394.1500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.7104
    Cell Significance Index: 14.8700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.6215
    Cell Significance Index: 8.4800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.6080
    Cell Significance Index: 39.2300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6001
    Cell Significance Index: 82.4100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5420
    Cell Significance Index: 25.2700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.5301
    Cell Significance Index: 90.5200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4715
    Cell Significance Index: 93.5800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4390
    Cell Significance Index: 194.0800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4337
    Cell Significance Index: 42.9000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.4269
    Cell Significance Index: 55.1600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.3970
    Cell Significance Index: 10.4400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3773
    Cell Significance Index: 71.8000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3771
    Cell Significance Index: 340.4900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3722
    Cell Significance Index: 17.5000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3372
    Cell Significance Index: 23.8500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3180
    Cell Significance Index: 39.1000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2959
    Cell Significance Index: 6.4100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2872
    Cell Significance Index: 14.9200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2580
    Cell Significance Index: 6.8900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1932
    Cell Significance Index: 34.8200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1696
    Cell Significance Index: 4.5500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1585
    Cell Significance Index: 4.4300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1552
    Cell Significance Index: 3.8800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1265
    Cell Significance Index: 3.6300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1263
    Cell Significance Index: 9.4100
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.1051
    Cell Significance Index: 0.6500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0836
    Cell Significance Index: 52.1800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0675
    Cell Significance Index: 13.5500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0634
    Cell Significance Index: 1.3500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0593
    Cell Significance Index: 1.9000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0528
    Cell Significance Index: 39.9600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0522
    Cell Significance Index: 0.5400
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.0507
    Cell Significance Index: 0.4000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0484
    Cell Significance Index: 0.8100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0432
    Cell Significance Index: 1.9600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0108
    Cell Significance Index: 3.8800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0036
    Cell Significance Index: 5.5000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0004
    Cell Significance Index: 0.2800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0042
    Cell Significance Index: -7.6600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0052
    Cell Significance Index: -9.7000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0076
    Cell Significance Index: -5.6600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0105
    Cell Significance Index: -1.3500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0113
    Cell Significance Index: -15.4300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0116
    Cell Significance Index: -1.1800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0230
    Cell Significance Index: -16.8700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0282
    Cell Significance Index: -15.9100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0318
    Cell Significance Index: -20.1900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0405
    Cell Significance Index: -2.1300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0468
    Cell Significance Index: -21.2200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0551
    Cell Significance Index: -15.8600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0555
    Cell Significance Index: -1.9500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0579
    Cell Significance Index: -0.3500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0583
    Cell Significance Index: -12.2800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0625
    Cell Significance Index: -0.7100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0639
    Cell Significance Index: -7.3200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0752
    Cell Significance Index: -1.9200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0786
    Cell Significance Index: -8.9700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1157
    Cell Significance Index: -13.4800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1462
    Cell Significance Index: -7.6200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1480
    Cell Significance Index: -21.5100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1652
    Cell Significance Index: -10.4100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2050
    Cell Significance Index: -21.3500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2065
    Cell Significance Index: -5.6200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2167
    Cell Significance Index: -14.5700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2523
    Cell Significance Index: -4.2500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2537
    Cell Significance Index: -20.0900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2664
    Cell Significance Index: -20.4500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2792
    Cell Significance Index: -17.1200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2842
    Cell Significance Index: -15.9500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.2941
    Cell Significance Index: -4.5500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2969
    Cell Significance Index: -12.1600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3160
    Cell Significance Index: -19.4200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.3411
    Cell Significance Index: -5.0400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3507
    Cell Significance Index: -6.0100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3590
    Cell Significance Index: -18.1400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3621
    Cell Significance Index: -5.4300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Enzymatic Activity:** SHMT2 catalyzes the conversion of serine to glycine, a crucial step in the one-carbon metabolic pathway. 2. **Mitochondrial Localization:** SHMT2 is predominantly localized to the mitochondrial matrix, where it regulates aerobic respiration and oxidative phosphorylation. 3. **Interactions with Other Proteins:** SHMT2 interacts with various proteins, including pyridoxal phosphate-binding proteins, which regulate its enzymatic activity and cellular localization. 4. **Expression in Specific Cell Types:** SHMT2 is expressed in a range of cell types, including ovarian surface epithelial cells, B-1 B cells, and myoepithelial cells of the mammary gland. **Pathways and Functions:** 1. **One-Carbon Metabolic Pathway:** SHMT2 plays a critical role in the one-carbon metabolic pathway, regulating the conversion of serine to glycine. 2. **Aerobic Respiration:** SHMT2 regulates aerobic respiration by controlling the availability of one-carbon units for the electron transport chain. 3. **Protein Degradation:** SHMT2 is involved in the regulation of protein degradation, particularly in the context of mitochondrial protein degradation. 4. **Mitochondrial Translation:** SHMT2 regulates mitochondrial translation, ensuring the proper functioning of the mitochondrial ribosome. 5. **Cell Proliferation:** SHMT2 is involved in the regulation of cell proliferation, particularly in the context of B-1 B cells and other hematopoietic cells. **Clinical Significance:** 1. **Dysregulation of One-Carbon Metabolism:** SHMT2 dysregulation has been implicated in various diseases, including cancer, neurological disorders, and metabolic disorders. 2. **Therapeutic Targeting:** SHMT2 is considered a potential therapeutic target for the treatment of diseases characterized by dysregulated one-carbon metabolism. 3. **Cancer Research:** SHMT2 has been implicated in the regulation of cancer cell proliferation and survival, highlighting its potential as a therapeutic target in cancer therapy. 4. **Neurological Disorders:** SHMT2 dysregulation has been linked to neurological disorders, including Alzheimer's disease and Parkinson's disease, emphasizing the need for further research into its role in these diseases. In conclusion, SHMT2 is a multifaceted enzyme that plays a critical role in various cellular processes, including one-carbon metabolism, aerobic respiration, protein degradation, and mitochondrial translation. Its dysregulation has been implicated in various diseases, highlighting the need for further research into its role in human health and disease.

Genular Protein ID: 1936995966

Symbol: GLYM_HUMAN

Name: Serine hydroxymethyltransferase, mitochondrial

UniProtKB Accession Codes:

P34897 B7Z9F1 E7EQ19 E7EU43 O00740 Q8N1A5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CORUM 1 CTD 1 ChEBI 6 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 DrugCentral 1 EC 1 EMBL 12 EMDB 4 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 30 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 24 PDBsum 24 PIR 1 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 3 RefSeq 5 Rhea 2 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10828359

Title: The genetic organization and protein crystallographic structure of human serine hydroxymethyltransferase.

PubMed ID: 10828359

DOI: 10.1016/s0065-2571(99)00035-7

PubMed ID: 8999870

Title: Molecular cloning, characterization, and regulation of the human mitochondrial serine hydroxymethyltransferase gene.

PubMed ID: 8999870

DOI: 10.1074/jbc.272.3.1842

PubMed ID: 8505317

Title: Cloning of human cDNAs encoding mitochondrial and cytosolic serine hydroxymethyltransferases and chromosomal localization.

PubMed ID: 8505317

DOI: 10.1016/s0021-9258(19)50286-1

PubMed ID: 18063578

Title: The layered structure of human mitochondrial DNA nucleoids.

PubMed ID: 18063578

DOI: 10.1074/jbc.m708444200

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21876188

Title: Identification of a de novo thymidylate biosynthesis pathway in mammalian mitochondria.

PubMed ID: 21876188

DOI: 10.1073/pnas.1103623108

PubMed ID: 24075985

Title: A BRISC-SHMT complex deubiquitinates IFNAR1 and regulates interferon responses.

PubMed ID: 24075985

DOI: 10.1016/j.celrep.2013.08.025

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25902260

Title: Autism and intellectual disability-associated KIRREL3 interacts with neuronal proteins MAP1B and MYO16 with potential roles in neurodevelopment.

PubMed ID: 25902260

DOI: 10.1371/journal.pone.0123106

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29180469

Title: SHMT2 desuccinylation by SIRT5 drives cancer cell proliferation.

PubMed ID: 29180469

DOI: 10.1158/0008-5472.can-17-1912

PubMed ID: 29452640

Title: Serine catabolism by SHMT2 is required for proper mitochondrial translation initiation and maintenance of formylmethionyl-tRNAs.

PubMed ID: 29452640

DOI: 10.1016/j.molcel.2018.01.024

PubMed ID: 29364879

Title: Mitochondrial translation requires folate-dependent tRNA methylation.

PubMed ID: 29364879

DOI: 10.1038/nature25460

PubMed ID: 33015733

Title: Impairment of the mitochondrial one-carbon metabolism enzyme SHMT2 causes a novel brain and heart developmental syndrome.

PubMed ID: 33015733

DOI: 10.1007/s00401-020-02223-w

PubMed ID: 25619277

Title: How pyridoxal 5'-phosphate differentially regulates human cytosolic and mitochondrial serine hydroxymethyltransferase oligomeric state.

PubMed ID: 25619277

DOI: 10.1111/febs.13211

Sequence Information:

  • Length: 504
  • Mass: 55993
  • Checksum: 7A13AF741C68FFD6
  • Sequence:
    • MLYFSLFWAA RPLQRCGQLV RMAIRAQHSN AAQTQTGEAN RGWTGQESLS DSDPEMWELL 
QREKDRQCRG LELIASENFC SRAALEALGS CLNNKYSEGY PGKRYYGGAE VVDEIELLCQ 
RRALEAFDLD PAQWGVNVQP YSGSPANLAV YTALLQPHDR IMGLDLPDGG HLTHGYMSDV 
KRISATSIFF ESMPYKLNPK TGLIDYNQLA LTARLFRPRL IIAGTSAYAR LIDYARMREV 
CDEVKAHLLA DMAHISGLVA AKVIPSPFKH ADIVTTTTHK TLRGARSGLI FYRKGVKAVD 
PKTGREIPYT FEDRINFAVF PSLQGGPHNH AIAAVAVALK QACTPMFREY SLQVLKNARA 
MADALLERGY SLVSGGTDNH LVLVDLRPKG LDGARAERVL ELVSITANKN TCPGDRSAIT 
PGGLRLGAPA LTSRQFREDD FRRVVDFIDE GVNIGLEVKS KTAKLQDFKS FLLKDSETSQ 
RLANLRQRVE QFARAFPMPG FDEH

Genular Protein ID: 268004861

Symbol: B4DLV4_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DLV4

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 6 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 4 GO 16 Gene3D 2 InterPro 7 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 PeptideAtlas 1 Pfam 2 ProteomicsDB 1 RefSeq 4 Rhea 1 RuleBase 1 SUPFAM 1 UniPathway 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 408
  • Mass: 44616
  • Checksum: 439896A302217089
  • Sequence:
    • MGEQRWWMKL SCCASAGPWK PLTWILHSGE SMSSPTPGPQ PTWPSTQPFC NLTTGSWGWT 
CPMGAISPTA TCLTSSGYQP RPSSSSLCPI SSTALAVCVS VQPKTGLIDY NQLALTARLF 
RPRLIIAGTS AYARLIDYAR MREVCDEVKA HLLADMAHIS GLVAAKVIPS PFKHADIVTT 
TTHKTLRGAR SGLIFYRKGV KAVDPKTGRE IPYTFEDRIN FAVFPSLQGG PHNHAIAAVA 
VALKQACTPM FREYSLQVLK NARAMADALL ERGYSLVSGG TDNHLVLVDL RPKGLDGARA 
ERVLELVSIT ANKNTCPGDR SAITPGGLRL GAPALTSRQF REDDFRRVVD FIDEGVNIGL 
EVKSKTAKLQ DFKSFLLKDS ETSQRLANLR QRVEQFARAF PMPGFDEH

Genular Protein ID: 3627743507

Symbol: B4DJQ3_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DJQ3

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 6 DNASU 1 DisGeNET 1 EC 1 EMBL 2 GO 16 Gene3D 2 HAMAP 1 InterPro 7 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 1 PROSITE 1 Pfam 2 PharmGKB 1 RefSeq 1 Rhea 1 RuleBase 1 SAM 1 SUPFAM 1 UniPathway 1

Sequence Information:

  • Length: 483
  • Mass: 53443
  • Checksum: B7F67CAA93952B69
  • Sequence:
    • MAIRAQHSNA AQTQTGEANR GWTGQESLSD SDPEMWELLQ REKDRQCRGL ELIASENFCS 
RAALEALGSC LNNKYSEGYP GKRYYGGAEV VDEIELLCQR RALEAFDLDP AQWGVNVQPY 
SGSPANLAVY TALLQPHDRI MGLDLPDGGH LTHGYMSDVK RISATSIFFE SMPYKLNLKT 
GLIDYNQLAL TARLFRPRLT IAGTSAYARL IDYARMREVC DEVKAHLLAD MAHISGLVAA 
KVIPSPFKHA DIVTTTTHKT LRGARSGLIF YRKGVKAVDP KTGREIPYTF EDRINFAVFP 
SLQGGPHNHA IAAVAVALKQ ACTPMFREYS LQVLKNARAM ADALLERGYS LVSGGTDNHP 
VLVDLRPKGL DGARAERVLE LVSITANKNT CPGDRSAITP GGLRLGAPAL TSRQFREDDF 
RRVVDFIDEG VNIGLEVKSK TAKLQDFKSF LLKDSETSQR LANLRQRVEQ FARAFPMPGF 
DEH

Genular Protein ID: 3603467459

Symbol: Q5BJF5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5BJF5

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 6 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 2 GO 14 Gene3D 2 InterPro 7 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 1 PROSITE 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 5 Rhea 1 RuleBase 1 SUPFAM 1 UniPathway 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 480
  • Mass: 52910
  • Checksum: 1295CB9786042BE9
  • Sequence:
    • ELRCCTSLCF GRLGLCRDVG SWSGWPFGLS TATQPRLRLG KQTGAGQARR ACRTVILRCG 
SCCRGRRTGS VVAWSSLPQR YYGGAEVVDE IELLCQRRAL EAFDLDPAQW GVNVQPYSGS 
PANLAVYTAL LQPHDRIMGL DLPDGGHLTH GYMSDVKRIS ATSIFFESMP YKLNPKTGLI 
DYNQLALTAR LFRPRLIIAG TSAYARLIDY ARMREVCDEV KAHLLADMAH ISGLVAAKVI 
PSPFKHADIV TTTTHKTLRG ARSGLIFYRK GVKAVDPKTG REIPYTFEDR INFAVFPSLQ 
GGPHNHAIAA VAVALKQACT PMFREYSLQV LKNARAMADA LLERGYSLVS GGTDNHLVLV 
DLRPKGLDGA RAERVLELVS ITANKNTCPG DRSAITPGGL RLGAPALTSR QFREDDFRRV 
VDFIDEGVNI GLEVKSKTAK LQDFKSFLLK DSETSQRLAN LRQRVEQFAR AFPMPGFDEH

Genular Protein ID: 688635735

Symbol: Q5HYG8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5HYG8

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 6 DNASU 1 DisGeNET 1 EC 1 EMBL 2 GO 14 Gene3D 2 HAMAP 1 IntAct 1 InterPro 7 MINT 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 1 PROSITE 1 Pfam 2 PharmGKB 1 RefSeq 1 Rhea 1 RuleBase 1 SAM 1 SUPFAM 1 UniPathway 1

Sequence Information:

  • Length: 483
  • Mass: 53465
  • Checksum: 61A6B36D9E88BF85
  • Sequence:
    • MAIRAQHSNA AQTQTGEANR GWTGQESLSD SDPEMWELLQ REKDRQCRGL ELIASENFCS 
RAALEALGSC LNNKYPEGYP GKRYYGGAEV VDEIELLCQR RALEAFDLDP AQWGVNVQPY 
SGSPANLAVY TALLQPHDRI MGLDLPDGGH LTHGYMSDVK RISATSIFFE SMPYKLNPKT 
GLIDYNQLAL TARLFRPRLI IAGTSAYARL IDYARMREVC DEVKAHLLAD MAHISGLVAA 
KVIPSPFKHA DIVTTTTHKT LRGARSGLIF YRKGVKAVDP KTGREIPYTF EDRINFAVFP 
SLQGGPHNHA IAAVAVALKQ ACTPMFREYS LQVLKNARAM ADALLERGYS LVSGGTDNHL 
VLVDLRPKGL DGARAERVLE LVSITANKNT CPGDRSAITP GGLRLGAPAL TSRQFREDDF 
RRVVDFIDEG VNIGLEVKSK TAKLQDFKSF LLKDSETSQR LANLRQRVEQ FARAFPMPGF 
DEH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.