Details for: SUMO2

Gene ID: 6613

Symbol: SUMO2

Ensembl ID: ENSG00000188612

Description: small ubiquitin like modifier 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 609.7905
    Cell Significance Index: -94.8500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 370.8356
    Cell Significance Index: -94.0600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 329.9449
    Cell Significance Index: -135.9200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 278.2116
    Cell Significance Index: -131.3500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 257.6474
    Cell Significance Index: -132.5300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 197.1321
    Cell Significance Index: -132.2800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 103.6087
    Cell Significance Index: -127.7500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 34.5662
    Cell Significance Index: -136.4000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 29.7160
    Cell Significance Index: -79.6100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 29.4453
    Cell Significance Index: -90.4400
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 13.2784
    Cell Significance Index: 82.1500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 8.4496
    Cell Significance Index: 293.6200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 8.3058
    Cell Significance Index: 106.3700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 8.1059
    Cell Significance Index: 169.6700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 6.9725
    Cell Significance Index: 55.6700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 6.8728
    Cell Significance Index: 180.7200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 6.4353
    Cell Significance Index: 69.9600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 5.4127
    Cell Significance Index: 254.3900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 5.2742
    Cell Significance Index: 724.3000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 5.1531
    Cell Significance Index: 270.5600
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 5.0258
    Cell Significance Index: 30.9300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 4.9144
    Cell Significance Index: 144.3300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 4.6170
    Cell Significance Index: 567.7100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 4.6081
    Cell Significance Index: 52.3500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.5090
    Cell Significance Index: 122.7300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 4.3705
    Cell Significance Index: 515.4200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 4.1472
    Cell Significance Index: 309.0900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 4.0999
    Cell Significance Index: 739.0900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.8890
    Cell Significance Index: 2123.8700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.8691
    Cell Significance Index: 110.9100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 3.6562
    Cell Significance Index: 258.5800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 3.6406
    Cell Significance Index: 1609.5800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 3.5311
    Cell Significance Index: 227.8100
  • Cell Name: theca cell (CL0000503)
    Fold Change: 3.3957
    Cell Significance Index: 19.9500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 3.3854
    Cell Significance Index: 31.1800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 3.3709
    Cell Significance Index: 77.8800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 3.3106
    Cell Significance Index: 424.4000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.2489
    Cell Significance Index: 151.4800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 3.1813
    Cell Significance Index: 411.0100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 3.1220
    Cell Significance Index: 55.1700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.9054
    Cell Significance Index: 53.7000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.6738
    Cell Significance Index: 86.9500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0535
    Cell Significance Index: 104.2100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9973
    Cell Significance Index: 200.0600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.7853
    Cell Significance Index: 134.1000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5398
    Cell Significance Index: 34.0300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4406
    Cell Significance Index: 83.8400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.4352
    Cell Significance Index: 125.2200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3912
    Cell Significance Index: 140.3200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.3404
    Cell Significance Index: 257.6300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2443
    Cell Significance Index: 48.4800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.2183
    Cell Significance Index: 160.0800
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.1900
    Cell Significance Index: 1.4400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1879
    Cell Significance Index: 3.1500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0757
    Cell Significance Index: 4.6500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0425
    Cell Significance Index: -31.4600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0473
    Cell Significance Index: -4.8300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0568
    Cell Significance Index: -106.9800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0650
    Cell Significance Index: -40.5600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0721
    Cell Significance Index: -133.0000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0868
    Cell Significance Index: -133.5700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0966
    Cell Significance Index: -131.3400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1465
    Cell Significance Index: -82.6100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.1629
    Cell Significance Index: -112.6500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1865
    Cell Significance Index: -118.4200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2373
    Cell Significance Index: -49.9800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.2710
    Cell Significance Index: -122.9900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3814
    Cell Significance Index: -21.4000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4101
    Cell Significance Index: -10.9700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4533
    Cell Significance Index: -11.5800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.5018
    Cell Significance Index: -13.4000
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.5280
    Cell Significance Index: -4.0700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.5342
    Cell Significance Index: -61.2000
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -0.5353
    Cell Significance Index: -4.6000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.6334
    Cell Significance Index: -73.8100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6621
    Cell Significance Index: -52.4400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.8517
    Cell Significance Index: -97.2200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.8551
    Cell Significance Index: -124.3000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.8797
    Cell Significance Index: -24.5900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.8896
    Cell Significance Index: -44.9600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.2492
    Cell Significance Index: -40.0100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.3347
    Cell Significance Index: -138.9700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.3613
    Cell Significance Index: -104.4700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.4334
    Cell Significance Index: -24.7100
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -1.4940
    Cell Significance Index: -10.7300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -1.5953
    Cell Significance Index: -65.3700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.8892
    Cell Significance Index: -127.0300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.8936
    Cell Significance Index: -25.8400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.9354
    Cell Significance Index: -41.9300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -2.1290
    Cell Significance Index: -96.5000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -2.1569
    Cell Significance Index: -132.2400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -2.2659
    Cell Significance Index: -66.7400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -2.3004
    Cell Significance Index: -34.4700
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -2.3274
    Cell Significance Index: -19.5500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -2.4202
    Cell Significance Index: -28.8500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -2.6750
    Cell Significance Index: -56.9700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -2.8493
    Cell Significance Index: -73.2400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -2.8606
    Cell Significance Index: -126.5300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -3.1420
    Cell Significance Index: -102.8700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -3.1623
    Cell Significance Index: -75.8400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SUMO2 is a 12-kDa protein that is covalently attached to target proteins via a process called sumoylation. This post-translational modification is mediated by SUMO E3 ligases, which recognize specific sequences in target proteins and facilitate the transfer of SUMO2. SUMO2 is significantly expressed in various cell types, including immune cells, epithelial cells, and stem cells, suggesting its involvement in multiple cellular processes. **Pathways and Functions:** SUMO2 is involved in several key pathways, including: 1. **DNA Repair:** SUMO2 plays a role in the repair of DNA double-strand breaks, particularly through homologous recombination (HR) and single-strand annealing (SSA). This process is essential for maintaining genome stability and preventing mutations. 2. **Transcriptional Regulation:** SUMO2 is a positive regulator of transcription by RNA polymerase II, suggesting its involvement in the regulation of gene expression. It also interacts with transcription factors and co-regulators, influencing the transcriptional landscape of target genes. 3. **Metabolic Processes:** SUMO2 is involved in the metabolism of lipids, proteins, and steroids, highlighting its role in cellular homeostasis and energy balance. **Clinical Significance:** The dysregulation of SUMO2 has been implicated in various human diseases, including: 1. **Cancer:** Alterations in SUMO2 expression and function have been observed in cancer cells, suggesting its potential role as a tumor suppressor or oncogene. 2. **Autoimmune Diseases:** Abnormalities in SUMO2-mediated processes may contribute to the development of autoimmune diseases, such as rheumatoid arthritis and lupus. 3. **Neurological Disorders:** SUMO2 has been implicated in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. 4. **Metabolic Disorders:** Dysregulation of SUMO2-mediated metabolic processes may contribute to the development of metabolic disorders, such as obesity and diabetes. In conclusion, SUMO2 is a multifunctional protein that plays a critical role in DNA repair, transcriptional regulation, and metabolic processes. Its dysregulation has been implicated in various human diseases, highlighting the need for further research into the mechanisms of SUMO2-mediated processes and their implications for human health and disease.

Genular Protein ID: 459346929

Symbol: SUMO2_HUMAN

Name: N/A

UniProtKB Accession Codes:

P61956 B2R4I2 P55855 Q32Q42 Q6IPZ6 Q96HK1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 15 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 9 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 25 PDBsum 25 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 15 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 2 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8630065

Title: Cloning and expression of human homolog HSMT3 to yeast SMT3 suppressor of MIF2 mutations in a centromere protein gene.

PubMed ID: 8630065

DOI: 10.1006/bbrc.1996.0717

PubMed ID: 9119407

Title: SMT3A, a human homologue of the S. cerevisiae SMT3 gene, maps to chromosome 21qter and defines a novel gene family.

PubMed ID: 9119407

DOI: 10.1006/geno.1996.4556

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9556629

Title: Characterization of a second member of the sentrin family of ubiquitin-like proteins.

PubMed ID: 9556629

DOI: 10.1074/jbc.273.18.11349

PubMed ID: 10692421

Title: Functional heterogeneity of small ubiquitin-related protein modifiers SUMO-1 versus SUMO-2/3.

PubMed ID: 10692421

DOI: 10.1074/jbc.275.9.6252

PubMed ID: 11451954

Title: Polymeric chains of SUMO-2 and SUMO-3 are conjugated to protein substrates by SAE1/SAE2 and Ubc9.

PubMed ID: 11451954

DOI: 10.1074/jbc.m104214200

PubMed ID: 12383504

Title: Molecular features of human ubiquitin-like SUMO genes and their encoded proteins.

PubMed ID: 12383504

DOI: 10.1016/s0378-1119(02)00843-0

PubMed ID: 12924945

Title: Role of an N-terminal site of Ubc9 in SUMO-1, -2, and -3 binding and conjugation.

PubMed ID: 12924945

DOI: 10.1021/bi0345283

PubMed ID: 15296745

Title: A basis for SUMO protease specificity provided by analysis of human Senp2 and a Senp2-SUMO complex.

PubMed ID: 15296745

DOI: 10.1016/j.str.2004.05.023

PubMed ID: 15487983

Title: Mapping residues of SUMO precursors essential in differential maturation by SUMO-specific protease, SENP1.

PubMed ID: 15487983

DOI: 10.1042/bj20041210

PubMed ID: 16567619

Title: NXP-2 association with SUMO-2 depends on lysines required for transcriptional repression.

PubMed ID: 16567619

DOI: 10.1073/pnas.0601066103

PubMed ID: 18538659

Title: Mechanism and consequences for paralog-specific sumoylation of ubiquitin-specific protease 25.

PubMed ID: 18538659

DOI: 10.1016/j.molcel.2008.03.021

PubMed ID: 18408734

Title: RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation.

PubMed ID: 18408734

DOI: 10.1038/ncb1716

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20388717

Title: In vivo identification of sumoylation sites by a signature tag and cysteine-targeted affinity purification.

PubMed ID: 20388717

DOI: 10.1074/jbc.m110.106955

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21965678

Title: SUMOylation and SUMO-interacting motif (SIM) of metastasis tumor antigen 1 (MTA1) synergistically regulate its transcriptional repressor function.

PubMed ID: 21965678

DOI: 10.1074/jbc.m111.267237

PubMed ID: 22406621

Title: The SUMO E3-ligase PIAS1 regulates the tumor suppressor PML and its oncogenic counterpart PML-RARA.

PubMed ID: 22406621

DOI: 10.1158/0008-5472.can-11-3159

PubMed ID: 23086935

Title: PolySUMO-binding proteins identified through a string search.

PubMed ID: 23086935

DOI: 10.1074/jbc.m112.410985

PubMed ID: 22398289

Title: SUMO binding by the Epstein-Barr virus protein kinase BGLF4 is crucial for BGLF4 function.

PubMed ID: 22398289

DOI: 10.1128/jvi.00314-12

PubMed ID: 23560854

Title: Ube2W conjugates ubiquitin to alpha-amino groups of protein N-termini.

PubMed ID: 23560854

DOI: 10.1042/bj20130244

PubMed ID: 24105744

Title: A SUMO-dependent interaction between Senataxin and the exosome, disrupted in the neurodegenerative disease AOA2, targets the exosome to sites of transcription-induced DNA damage.

PubMed ID: 24105744

DOI: 10.1101/gad.224923.113

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 30914427

Title: SUMOylation promotes protective responses to DNA-protein cross-links.

PubMed ID: 30914427

DOI: 10.15252/embj.2019101496

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 15479240

Title: Crystal structures of the human SUMO-2 protein at 1.6 A and 1.2 A resolution: implication on the functional differences of SUMO proteins.

PubMed ID: 15479240

DOI: 10.1111/j.1432-1033.2004.04349.x

PubMed ID: 16626738

Title: Crystal structure of SUMO-3-modified thymine-DNA glycosylase.

PubMed ID: 16626738

DOI: 10.1016/j.jmb.2006.03.036

PubMed ID: 26524494

Title: Structural basis for catalytic activation by the human ZNF451 SUMO E3 ligase.

PubMed ID: 26524494

DOI: 10.1038/nsmb.3116

Sequence Information:

  • Length: 95
  • Mass: 10871
  • Checksum: F8F0426849BEF08B
  • Sequence:
    • MADEKPKEGV KTENNDHINL KVAGQDGSVV QFKIKRHTPL SKLMKAYCER QGLSMRQIRF 
RFDGQPINET DTPAQLEMED EDTIDVFQQQ TGGVY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.