Details for: TST

Gene ID: 7263

Symbol: TST

Ensembl ID: ENSG00000128311

Description: thiosulfate sulfurtransferase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 66.1544
    Cell Significance Index: -10.2900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 58.7439
    Cell Significance Index: -14.9000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 35.1255
    Cell Significance Index: -14.2700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 31.8924
    Cell Significance Index: -16.4100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 24.3360
    Cell Significance Index: -16.3300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 14.7998
    Cell Significance Index: -14.1300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 11.7522
    Cell Significance Index: -14.4900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 6.8666
    Cell Significance Index: 102.8900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.7786
    Cell Significance Index: -15.4800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.9280
    Cell Significance Index: -15.5000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 3.3363
    Cell Significance Index: 77.0800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 3.2647
    Cell Significance Index: 147.9800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 2.6345
    Cell Significance Index: 2378.7100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.5924
    Cell Significance Index: 134.6700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.4385
    Cell Significance Index: 22.4600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.2548
    Cell Significance Index: 48.8500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.8048
    Cell Significance Index: -3.9500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.6639
    Cell Significance Index: 908.6900
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 1.4889
    Cell Significance Index: 15.0200
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 1.2310
    Cell Significance Index: 17.0800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.1870
    Cell Significance Index: 213.9700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.1806
    Cell Significance Index: 31.6400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.0989
    Cell Significance Index: 31.6600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.0717
    Cell Significance Index: 26.7900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.9583
    Cell Significance Index: 66.2700
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.9320
    Cell Significance Index: 3.5100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.8947
    Cell Significance Index: 110.0100
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.8591
    Cell Significance Index: 14.4500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8156
    Cell Significance Index: 161.8600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.7369
    Cell Significance Index: 34.3600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6361
    Cell Significance Index: 87.3500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.6082
    Cell Significance Index: 19.4800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.4627
    Cell Significance Index: 52.8200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.4546
    Cell Significance Index: 12.1600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4334
    Cell Significance Index: 27.9600
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.2860
    Cell Significance Index: 2.9500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2802
    Cell Significance Index: 47.8500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.2640
    Cell Significance Index: 4.0900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2532
    Cell Significance Index: 111.9400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2296
    Cell Significance Index: 43.7000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1852
    Cell Significance Index: 4.8700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1638
    Cell Significance Index: 7.7000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.1567
    Cell Significance Index: 2.6400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0959
    Cell Significance Index: 2.6100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0872
    Cell Significance Index: 8.6300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0806
    Cell Significance Index: 1.1900
  • Cell Name: colonocyte (CL1000347)
    Fold Change: 0.0728
    Cell Significance Index: 0.4500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0680
    Cell Significance Index: 4.8100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0661
    Cell Significance Index: 7.7900
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.0634
    Cell Significance Index: 0.3700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 0.0582
    Cell Significance Index: 4.6100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0487
    Cell Significance Index: 36.8400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0462
    Cell Significance Index: 33.8700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0247
    Cell Significance Index: 0.6900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0198
    Cell Significance Index: 2.5400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0040
    Cell Significance Index: -0.3000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0046
    Cell Significance Index: -8.6100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0050
    Cell Significance Index: -3.1500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0076
    Cell Significance Index: -14.0500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0078
    Cell Significance Index: -5.7900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0097
    Cell Significance Index: -14.9900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0113
    Cell Significance Index: -1.1500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0122
    Cell Significance Index: -16.6400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0148
    Cell Significance Index: -9.3900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0150
    Cell Significance Index: -8.4500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0202
    Cell Significance Index: -0.5400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0217
    Cell Significance Index: -2.8100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0237
    Cell Significance Index: -0.2500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0246
    Cell Significance Index: -2.8200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0300
    Cell Significance Index: -6.3200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0321
    Cell Significance Index: -14.5700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0353
    Cell Significance Index: -12.6500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0432
    Cell Significance Index: -1.2700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0439
    Cell Significance Index: -12.6300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0487
    Cell Significance Index: -7.0800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0585
    Cell Significance Index: -11.7300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0694
    Cell Significance Index: -5.3300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0698
    Cell Significance Index: -8.1300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0759
    Cell Significance Index: -1.9400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0909
    Cell Significance Index: -4.5900
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0916
    Cell Significance Index: -0.7000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0949
    Cell Significance Index: -1.3000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1162
    Cell Significance Index: -2.4800
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.1177
    Cell Significance Index: -1.0000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1351
    Cell Significance Index: -7.5800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1405
    Cell Significance Index: -7.3200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1456
    Cell Significance Index: -15.1600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1577
    Cell Significance Index: -5.4800
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.1661
    Cell Significance Index: -3.4700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1754
    Cell Significance Index: -1.4300
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.1929
    Cell Significance Index: -1.5400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1956
    Cell Significance Index: -5.7600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1999
    Cell Significance Index: -3.3500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2102
    Cell Significance Index: -3.8900
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.2128
    Cell Significance Index: -1.3200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2151
    Cell Significance Index: -13.1900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2251
    Cell Significance Index: -7.9100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2348
    Cell Significance Index: -14.8000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2354
    Cell Significance Index: -14.4700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2368
    Cell Significance Index: -2.6900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Multifunctional enzyme**: TST exhibits multiple enzymatic activities, including thiosulfate sulfurtransferase, 3-mercaptopyruvate sulfurtransferase, and cysteine desulfhydrase. 2. **Widespread expression**: TST is expressed in various cell types, including colon epithelial cells, enterocytes, epithelial cells of the proximal tubule, and stem cells. 3. **Metabolic significance**: TST is involved in the catabolism of sulfur-containing amino acids and the oxidation of sulfide to sulfate, which is essential for maintaining cellular redox balance. 4. **Immune regulation**: Recent studies suggest that TST plays a role in regulating immune responses, possibly through the modulation of cytokine production and immune cell function. **Pathways and Functions:** 1. **Metabolism of sulfur-containing amino acids**: TST is involved in the catabolism of cysteine and homocysteine, which are essential sulfur-containing amino acids. 2. **Sulfide oxidation to sulfate**: TST is responsible for the oxidation of sulfide to sulfate, which is a critical step in maintaining cellular redox balance. 3. **Epithelial differentiation**: TST is expressed in epithelial cells, where it may play a role in regulating epithelial differentiation and maintenance. 4. **Mitochondrial function**: TST is localized to the mitochondrial matrix, where it may contribute to mitochondrial function and redox balance. 5. **Immune regulation**: TST may regulate immune responses through the modulation of cytokine production and immune cell function. **Clinical Significance:** 1. **Cysteine metabolism disorders**: Abnormalities in TST expression or function may contribute to cysteine metabolism disorders, such as cystinuria and homocystinuria. 2. **Cancer and epithelial dysregulation**: Altered TST expression has been observed in various cancers, suggesting its potential role in epithelial dysregulation and tumorigenesis. 3. **Neurological disorders**: TST may play a role in neurological disorders, such as Alzheimer's disease and Parkinson's disease, where mitochondrial dysfunction and oxidative stress are prominent features. 4. **Immunological disorders**: Abnormal TST expression may contribute to immunological disorders, such as autoimmune diseases and inflammatory conditions. In conclusion, thiosulfate sulfurtransferase (TST) is a multifunctional enzyme that plays a critical role in regulating metabolic processes, immune responses, and epithelial differentiation. Further studies are needed to fully elucidate the complexities of TST and its significance in various diseases.

Genular Protein ID: 3115380331

Symbol: THTR_HUMAN

Name: Thiosulfate sulfurtransferase

UniProtKB Accession Codes:

Q16762 B3KRM1 Q6IB06

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEBI 5 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EC 2 EMBL 7 Ensembl 3 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 2 RefSeq 2 Rhea 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9070219

Title: Cloning and expression of human liver rhodanese cDNA.

PubMed ID: 9070219

DOI: 10.1006/bbrc.1996.6046

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20663881

Title: Mitochondrial enzyme rhodanese is essential for 5 S ribosomal RNA import into human mitochondria.

PubMed ID: 20663881

DOI: 10.1074/jbc.m110.151183

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21685364

Title: Biological significance of 5S rRNA import into human mitochondria: role of ribosomal protein MRP-L18.

PubMed ID: 21685364

DOI: 10.1101/gad.624711

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 297
  • Mass: 33429
  • Checksum: BDAE6EE4E47A5650
  • Sequence:
    • MVHQVLYRAL VSTKWLAESI RTGKLGPGLR VLDASWYSPG TREARKEYLE RHVPGASFFD 
IEECRDTASP YEMMLPSEAG FAEYVGRLGI SNHTHVVVYD GEHLGSFYAP RVWWMFRVFG 
HRTVSVLNGG FRNWLKEGHP VTSEPSRPEP AVFKATLDRS LLKTYEQVLE NLESKRFQLV 
DSRSQGRFLG TEPEPDAVGL DSGHIRGAVN MPFMDFLTED GFEKGPEELR ALFQTKKVDL 
SQPLIATCRK GVTACHVALA AYLCGKPDVA VYDGSWSEWF RRAPPESRVS QGKSEKA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.