Details for: DDX5

Gene ID: 1655

Symbol: DDX5

Ensembl ID: ENSG00000108654

Description: DEAD-box helicase 5

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 8.87
    Marker Score: 117984.5
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 6.4
    Marker Score: 5008
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 6.06
    Marker Score: 2942
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 5.67
    Marker Score: 4815
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 5.23
    Marker Score: 3500
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 5.16
    Marker Score: 1513
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 4.94
    Marker Score: 3484
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 4.88
    Marker Score: 10226
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 4.82
    Marker Score: 20020
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 4.8
    Marker Score: 12208
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 4.71
    Marker Score: 46606.5
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 4.67
    Marker Score: 13635
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 4.62
    Marker Score: 2975
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 4.62
    Marker Score: 3497
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 4.53
    Marker Score: 14310
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 4.5
    Marker Score: 237762
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 4.43
    Marker Score: 150726
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 4.4
    Marker Score: 3195
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 4.4
    Marker Score: 2671
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 4.22
    Marker Score: 2166
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 4.14
    Marker Score: 11604
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 4.1
    Marker Score: 979
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.06
    Marker Score: 9910
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 4.06
    Marker Score: 2696
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 4.05
    Marker Score: 11198
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 4.05
    Marker Score: 54363
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 3.99
    Marker Score: 2129.5
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 3.98
    Marker Score: 3553
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 3.98
    Marker Score: 1783
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.97
    Marker Score: 4237
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 3.95
    Marker Score: 1457
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 3.94
    Marker Score: 1775
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 3.94
    Marker Score: 14006
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.92
    Marker Score: 219386
  • Cell Name: blood cell (CL0000081)
    Fold Change: 3.92
    Marker Score: 45518.5
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 3.9
    Marker Score: 3323
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 3.89
    Marker Score: 5631
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 3.85
    Marker Score: 3792
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 3.85
    Marker Score: 16502
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 3.79
    Marker Score: 84801
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 3.79
    Marker Score: 1629
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 3.79
    Marker Score: 3659
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 3.77
    Marker Score: 4917
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 3.77
    Marker Score: 1422
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 3.75
    Marker Score: 2942
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 3.74
    Marker Score: 5511
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 3.74
    Marker Score: 2278
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 3.74
    Marker Score: 9116
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 3.69
    Marker Score: 4598
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 3.66
    Marker Score: 32107
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 3.66
    Marker Score: 3146
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 3.65
    Marker Score: 2016.5
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 3.65
    Marker Score: 6267
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 3.65
    Marker Score: 961
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 3.65
    Marker Score: 3073
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 3.64
    Marker Score: 1270
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 3.62
    Marker Score: 6811
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 3.62
    Marker Score: 5019
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 3.59
    Marker Score: 2004
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 3.59
    Marker Score: 2940.5
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 3.58
    Marker Score: 820
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 3.56
    Marker Score: 2684
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 3.55
    Marker Score: 5466
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 3.55
    Marker Score: 1446
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 3.53
    Marker Score: 1754
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 3.52
    Marker Score: 4245
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 3.51
    Marker Score: 22909
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 3.51
    Marker Score: 3131
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 3.5
    Marker Score: 2152
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 3.5
    Marker Score: 1029
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 3.49
    Marker Score: 889
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 3.48
    Marker Score: 3273
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 3.48
    Marker Score: 3743
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 3.47
    Marker Score: 3609
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 3.46
    Marker Score: 1125
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 3.44
    Marker Score: 1394
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 3.43
    Marker Score: 1431
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 3.42
    Marker Score: 3797
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 3.41
    Marker Score: 3034
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 3.41
    Marker Score: 2243
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 3.41
    Marker Score: 2074
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 3.4
    Marker Score: 2988
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 3.4
    Marker Score: 1716
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 3.39
    Marker Score: 1175
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 3.38
    Marker Score: 3222
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 3.38
    Marker Score: 1749
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 3.38
    Marker Score: 16587
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 3.38
    Marker Score: 963
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 3.36
    Marker Score: 3650
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 3.35
    Marker Score: 2242
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 3.35
    Marker Score: 2536
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 3.33
    Marker Score: 4015
  • Cell Name: podocyte (CL0000653)
    Fold Change: 3.33
    Marker Score: 1232
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 3.32
    Marker Score: 1539
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 3.32
    Marker Score: 2926
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 3.31
    Marker Score: 1941
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 3.31
    Marker Score: 824
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 3.31
    Marker Score: 4561
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 3.3
    Marker Score: 8853
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 3.3
    Marker Score: 3777

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Other Information

**Key characteristics** * DDX5 is a helicase that is recruited to sites of DNA damage. * It is a key regulator of mRNA splicing by facilitating the removal of introns from pre-mRNA. * DDX5 is also involved in the regulation of protein translation and viral infection. **Pathways and functions** DDX5 is involved in several important pathways, including: * Disease: DDX5 is expressed in cardiac muscle cells and is required for the expression of genes involved in cardiac development and function. * Esr-mediated signaling: DDX5 is a key regulator of the estrogen-dependent gene expression (EDGE) pathway. * Estrogen-dependent gene expression: DDX5 is a key regulator of the expression of genes involved in estrogen-dependent gene expression. * Infectious disease: DDX5 is involved in the regulation of viral infection by facilitating the expression of viral mRNA and proteins. * Metabolism of proteins: DDX5 is involved in the regulation of protein translation by facilitating the removal of ribosomes from mRNA. **Clinical significance** DDX5 mutations have been linked to a number of human diseases, including: * Cardiovascular disease: Mutations in DDX5 have been linked to heart failure and arrhythmias. * Cancer: Mutations in DDX5 have been linked to a number of types of cancer, including breast cancer, lung cancer, and leukemia. * Neurological disorders: Mutations in DDX5 have been linked to autism and schizophrenia.

Genular Protein ID: 1709874619

Symbol: DDX5_HUMAN

Name: Probable ATP-dependent RNA helicase DDX5

UniProtKB Accession Codes:

P17844 B4DLW8 B5BU21 D3DU32 E7ETL9 O75681 Q53Y61

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CTD 1 ChEBI 8 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 2 EMBL 11 EPD 1 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 47 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 2 PIR 1 PRO 1 PROSITE 4 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 5 RefSeq 3 Rhea 1 SAM 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 1 SWISS-2DPAGE 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2349099

Title: Complete cDNA sequence of the human p68 protein.

PubMed ID: 2349099

DOI: 10.1093/nar/18.10.3045

PubMed ID: 1996094

Title: p68 RNA helicase: identification of a nucleolar form and cloning of related genes containing a conserved intron in yeasts.

PubMed ID: 1996094

DOI: 10.1128/mcb.11.3.1326-1333.1991

PubMed ID: 10648785

Title: Structure and expression of the human p68 RNA helicase gene.

PubMed ID: 10648785

DOI: 10.1093/nar/28.4.932

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2451786

Title: Nuclear protein with sequence homology to translation initiation factor eIF-4A.

PubMed ID: 2451786

DOI: 10.1038/332736a0

PubMed ID: 10409727

Title: Purification and identification of p68 RNA helicase acting as a transcriptional coactivator specific for the activation function 1 of human estrogen receptor alpha.

PubMed ID: 10409727

DOI: 10.1128/mcb.19.8.5363

PubMed ID: 24509260

Title:

PubMed ID: 24509260

DOI: 10.1128/mcb.01458-13

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 22034099

Title: The DEAD-box RNA helicase DDX3 interacts with DDX5, co-localizes with it in the cytoplasm during the G2/M phase of the cycle, and affects its shuttling during mRNP export.

PubMed ID: 22034099

DOI: 10.1002/jcb.23428

PubMed ID: 10837141

Title: The nuclear DEAD box RNA helicase p68 interacts with the nucleolar protein fibrillarin and colocalizes specifically in nascent nucleoli during telophase.

PubMed ID: 10837141

DOI: 10.1006/excr.2000.4886

PubMed ID: 11250900

Title: A subfamily of RNA-binding DEAD-box proteins acts as an estrogen receptor alpha coactivator through the N-terminal activation domain (AF-1) with an RNA coactivator, SRA.

PubMed ID: 11250900

DOI: 10.1093/emboj/20.6.1341

PubMed ID: 25452582

Title:

PubMed ID: 25452582

DOI: 10.15252/embj.201470090

PubMed ID: 11991638

Title: Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.

PubMed ID: 11991638

DOI: 10.1017/s1355838202021088

PubMed ID: 12595555

Title: The highly related DEAD box RNA helicases p68 and p72 exist as heterodimers in cells.

PubMed ID: 12595555

DOI: 10.1093/nar/gkg236

PubMed ID: 12527917

Title: Synergism between p68 RNA helicase and the transcriptional coactivators CBP and p300.

PubMed ID: 12527917

DOI: 10.1038/sj.onc.1206067

PubMed ID: 15298701

Title: The p68 and p72 DEAD box RNA helicases interact with HDAC1 and repress transcription in a promoter-specific manner.

PubMed ID: 15298701

DOI: 10.1186/1471-2199-5-11

PubMed ID: 15660129

Title: The DEAD box protein p68: a novel transcriptional coactivator of the p53 tumour suppressor.

PubMed ID: 15660129

DOI: 10.1038/sj.emboj.7600550

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 17011493

Title: The RNA helicases p68/p72 and the noncoding RNA SRA are coregulators of MyoD and skeletal muscle differentiation.

PubMed ID: 17011493

DOI: 10.1016/j.devcel.2006.08.003

PubMed ID: 17932509

Title: Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells.

PubMed ID: 17932509

DOI: 10.1038/sj.embor.7401088

PubMed ID: 17369852

Title: SUMO modification of the DEAD box protein p68 modulates its transcriptional activity and promotes its interaction with HDAC1.

PubMed ID: 17369852

DOI: 10.1038/sj.onc.1210387

PubMed ID: 18829551

Title: The RNA helicase p68 is a novel androgen receptor coactivator involved in splicing and is overexpressed in prostate cancer.

PubMed ID: 18829551

DOI: 10.1158/0008-5472.can-08-0932

PubMed ID: 18279852

Title: Transcription-dependent nucleolar cap localization and possible nuclear function of DExH RNA helicase RHAU.

PubMed ID: 18279852

DOI: 10.1016/j.yexcr.2008.01.006

PubMed ID: 17960593

Title: p68 (Ddx5) interacts with Runx2 and regulates osteoblast differentiation.

PubMed ID: 17960593

DOI: 10.1002/jcb.21526

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19718048

Title: The DEAD-box protein p72 regulates ERalpha-/oestrogen-dependent transcription and cell growth, and is associated with improved survival in ERalpha-positive breast cancer.

PubMed ID: 19718048

DOI: 10.1038/onc.2009.261

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 19995069

Title: Sumoylation of p68 and p72 RNA helicases affects protein stability and transactivation potential.

PubMed ID: 19995069

DOI: 10.1021/bi901263m

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21343338

Title: RNA helicase p68 (DDX5) regulates tau exon 10 splicing by modulating a stem-loop structure at the 5' splice site.

PubMed ID: 21343338

DOI: 10.1128/mcb.01149-10

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24644279

Title: Nuclear ARVCF protein binds splicing factors and contributes to the regulation of alternative splicing.

PubMed ID: 24644279

DOI: 10.1074/jbc.m113.530717

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 26030138

Title: Identification of Novel Proteins Co-Purifying with Cockayne Syndrome Group B (CSB) Reveals Potential Roles for CSB in RNA Metabolism and Chromatin Dynamics.

PubMed ID: 26030138

DOI: 10.1371/journal.pone.0128558

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 20941364

Title: Comparative structural analysis of human DEAD-box RNA helicases.

PubMed ID: 20941364

DOI: 10.1371/journal.pone.0012791

Sequence Information:

  • Length: 614
  • Mass: 69148
  • Checksum: 84DF684FD6871594
  • Sequence:
    • MSGYSSDRDR GRDRGFGAPR FGGSRAGPLS GKKFGNPGEK LVKKKWNLDE LPKFEKNFYQ 
EHPDLARRTA QEVETYRRSK EITVRGHNCP KPVLNFYEAN FPANVMDVIA RQNFTEPTAI 
QAQGWPVALS GLDMVGVAQT GSGKTLSYLL PAIVHINHQP FLERGDGPIC LVLAPTRELA 
QQVQQVAAEY CRACRLKSTC IYGGAPKGPQ IRDLERGVEI CIATPGRLID FLECGKTNLR 
RTTYLVLDEA DRMLDMGFEP QIRKIVDQIR PDRQTLMWSA TWPKEVRQLA EDFLKDYIHI 
NIGALELSAN HNILQIVDVC HDVEKDEKLI RLMEEIMSEK ENKTIVFVET KRRCDELTRK 
MRRDGWPAMG IHGDKSQQER DWVLNEFKHG KAPILIATDV ASRGLDVEDV KFVINYDYPN 
SSEDYIHRIG RTARSTKTGT AYTFFTPNNI KQVSDLISVL REANQAINPK LLQLVEDRGS 
GRSRGRGGMK DDRRDRYSAG KRGGFNTFRD RENYDRGYSS LLKRDFGAKT QNGVYSAANY 
TNGSFGSNFV SAGIQTSFRT GNPTGTYQNG YDSTQQYGSN VPNMHNGMNQ QAYAYPATAA 
APMIGYPMPT GYSQ

Genular Protein ID: 2703197575

Symbol: J3KTA4_HUMAN

Name: N/A

UniProtKB Accession Codes:

J3KTA4

Database IDs:

ARBA 10 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChEBI 5 ChiTaRS 1 DNASU 1 EC 1 EMBL 2 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 9 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 IntAct 1 InterPro 7 MINT 1 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 7 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 3 PhylomeDB 1 Proteomes 2 RefSeq 1 Rhea 1 RuleBase 1 SAM 1 SMART 3 SMR 1 SUPFAM 1 SwissPalm 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.O114.044792

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

Sequence Information:

  • Length: 614
  • Mass: 69087
  • Checksum: 015EB8FEC39957A2
  • Sequence:
    • MKAGRFEADE GTSVRFGAPR FGGSRAGPLS GKKFGNPGEK LVKKKWNLDE LPKFEKNFYQ 
EHPDLARRTA QEVETYRRSK EITVRGHNCP KPVLNFYEAN FPANVMDVIA RQNFTEPTAI 
QAQGWPVALS GLDMVGVAQT GSGKTLSYLL PAIVHINHQP FLERGDGPIC LVLAPTRELA 
QQVQQVAAEY CRACRLKSTC IYGGAPKGPQ IRDLERGVEI CIATPGRLID FLECGKTNLR 
RTTYLVLDEA DRMLDMGFEP QIRKIVDQIR PDRQTLMWSA TWPKEVRQLA EDFLKDYIHI 
NIGALELSAN HNILQIVDVC HDVEKDEKLI RLMEEIMSEK ENKTIVFVET KRRCDELTRK 
MRRDGWPAMG IHGDKSQQER DWVLNEFKHG KAPILIATDV ASRGLDVEDV KFVINYDYPN 
SSEDYIHRIG RTARSTKTGT AYTFFTPNNI KQVSDLISVL REANQAINPK LLQLVEDRGS 
GRSRGRGGMK DDRRDRYSAG KRGGFNTFRD RENYDRGYSS LLKRDFGAKT QNGVYSAANY 
TNGSFGSNFV SAGIQTSFRT GNPTGTYQNG YDSTQQYGSN VPNMHNGMNQ QAYAYPATAA 
APMIGYPMPT GYSQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.