Details for: DDX5

Gene ID: 1655

Symbol: DDX5

Ensembl ID: ENSG00000108654

Description: DEAD-box helicase 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 1289.7856
    Cell Significance Index: -200.6200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 778.1003
    Cell Significance Index: -197.3600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 581.4817
    Cell Significance Index: -239.5400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 541.0613
    Cell Significance Index: -219.8100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 540.8764
    Cell Significance Index: -255.3600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 473.9833
    Cell Significance Index: -243.8100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 382.4166
    Cell Significance Index: -256.6100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 232.8899
    Cell Significance Index: -222.3500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 178.3276
    Cell Significance Index: -219.8700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 62.2995
    Cell Significance Index: -191.3500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 59.3074
    Cell Significance Index: -234.0300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 59.1066
    Cell Significance Index: -129.3600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 57.4349
    Cell Significance Index: -153.8600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 5.8470
    Cell Significance Index: 159.1500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 5.5982
    Cell Significance Index: 717.6600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 5.4596
    Cell Significance Index: 671.3100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 5.1939
    Cell Significance Index: 244.1100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 5.1194
    Cell Significance Index: 922.8600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 4.4390
    Cell Significance Index: 286.3800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 4.0565
    Cell Significance Index: 557.0800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.9568
    Cell Significance Index: 2160.9200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 3.8954
    Cell Significance Index: 1722.2600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 3.8455
    Cell Significance Index: 133.6300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 3.7757
    Cell Significance Index: 196.6700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 3.5178
    Cell Significance Index: 92.5000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 3.2903
    Cell Significance Index: 425.0900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 3.1828
    Cell Significance Index: 56.2500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.9372
    Cell Significance Index: 218.9100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.8145
    Cell Significance Index: 331.9200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 2.7767
    Cell Significance Index: 196.3800
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 2.6546
    Cell Significance Index: 83.9600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.4992
    Cell Significance Index: 71.6400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.4577
    Cell Significance Index: 493.0200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.3195
    Cell Significance Index: 42.8700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 2.1375
    Cell Significance Index: 232.5000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.9220
    Cell Significance Index: 147.4900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.9001
    Cell Significance Index: 88.5900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.8358
    Cell Significance Index: 364.3200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.6474
    Cell Significance Index: 590.9100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.6199
    Cell Significance Index: 45.2700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.2008
    Cell Significance Index: 54.4300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.1690
    Cell Significance Index: 33.6800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.9049
    Cell Significance Index: 55.6200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.7356
    Cell Significance Index: 508.7500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5704
    Cell Significance Index: 92.7700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.5167
    Cell Significance Index: 5.8700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.5135
    Cell Significance Index: 790.5900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4824
    Cell Significance Index: 25.0600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.4380
    Cell Significance Index: 278.1500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.4372
    Cell Significance Index: 74.6500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.4284
    Cell Significance Index: 806.6300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.4237
    Cell Significance Index: 8.2700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1531
    Cell Significance Index: 282.4100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0913
    Cell Significance Index: 41.4400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0745
    Cell Significance Index: 56.4100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0580
    Cell Significance Index: 78.8900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0217
    Cell Significance Index: 15.9100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0193
    Cell Significance Index: 1.9100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0070
    Cell Significance Index: -0.3700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0076
    Cell Significance Index: -1.4400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0457
    Cell Significance Index: -1.2200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1110
    Cell Significance Index: -82.2400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1230
    Cell Significance Index: -12.5600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.2006
    Cell Significance Index: -125.2800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2227
    Cell Significance Index: -25.4200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2294
    Cell Significance Index: -3.8400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.3034
    Cell Significance Index: -171.1200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3221
    Cell Significance Index: -3.8400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3644
    Cell Significance Index: -8.4200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.4874
    Cell Significance Index: -17.1300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.5133
    Cell Significance Index: -108.1100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.5567
    Cell Significance Index: -80.9300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.8370
    Cell Significance Index: -46.9700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.8497
    Cell Significance Index: -244.4700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.1171
    Cell Significance Index: -70.4100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.1282
    Cell Significance Index: -75.8600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -1.1953
    Cell Significance Index: -136.9400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -1.3218
    Cell Significance Index: -38.8200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -1.3826
    Cell Significance Index: -28.9400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -1.4170
    Cell Significance Index: -165.1400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.8151
    Cell Significance Index: -189.0000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.8609
    Cell Significance Index: -82.3100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -2.2566
    Cell Significance Index: -57.6500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -2.4328
    Cell Significance Index: -192.6800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -2.4575
    Cell Significance Index: -93.0600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -2.5037
    Cell Significance Index: -34.1600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -2.8978
    Cell Significance Index: -77.5200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -3.1335
    Cell Significance Index: -28.8600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -3.4485
    Cell Significance Index: -238.4800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -4.0024
    Cell Significance Index: -68.5900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -4.0031
    Cell Significance Index: -59.1000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -4.0672
    Cell Significance Index: -249.3600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -4.2522
    Cell Significance Index: -60.5300
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -4.3367
    Cell Significance Index: -74.7600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -4.6942
    Cell Significance Index: -112.5800
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -4.7506
    Cell Significance Index: -68.2200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -4.7704
    Cell Significance Index: -152.7900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -4.8899
    Cell Significance Index: -53.1600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -4.9583
    Cell Significance Index: -108.5700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -4.9757
    Cell Significance Index: -127.9000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** DDX5 is a 420-kDa protein that belongs to the DEAD-box helicase family, which is characterized by its ability to unwind double-stranded RNA (dsRNA) and single-stranded RNA (ssRNA) into single-stranded RNA (ssRNA). DDX5 is a ATP-dependent RNA helicase that exhibits a high degree of sequence homology with other DEAD-box helicases. Its structure consists of a central helicase domain, a C-terminal domain, and a N-terminal domain. The helicase domain is responsible for unwinding dsRNA and ssRNA, while the C-terminal domain is involved in protein-protein interactions. The N-terminal domain is involved in binding to RNA and other proteins. **Pathways and Functions** DDX5 plays a crucial role in various cellular processes, including: 1. **Alternative mRNA splicing**: DDX5 is involved in the regulation of alternative mRNA splicing, which is a process that involves the selection of different exons from a single gene to produce a mature mRNA molecule. 2. **Androgen receptor signaling**: DDX5 is involved in the regulation of androgen receptor signaling, which is a process that involves the binding of androgens to the androgen receptor protein, leading to the regulation of gene expression. 3. **Viral genome replication**: DDX5 is involved in the replication of viral genomes, including the SARS-CoV-1 and SARS-CoV-2 genomes. 4. **RNA metabolism**: DDX5 is involved in the regulation of RNA metabolism, including the processing of pre-mRNA, the splicing of introns, and the degradation of RNA. 5. **Transcriptional regulation**: DDX5 is involved in the regulation of transcriptional processes, including the regulation of gene expression by RNA polymerase II. **Clinical Significance** DDX5 has been implicated in various diseases, including: 1. **Cancer**: DDX5 has been found to be overexpressed in various types of cancer, including breast cancer, lung cancer, and colon cancer. 2. **Infectious diseases**: DDX5 has been found to be involved in the replication of viral genomes, including the SARS-CoV-1 and SARS-CoV-2 genomes. 3. **Neurological disorders**: DDX5 has been found to be involved in the regulation of RNA metabolism in the brain, and has been implicated in various neurological disorders, including Alzheimer's disease and Parkinson's disease. 4. **Cardiovascular diseases**: DDX5 has been found to be involved in the regulation of RNA metabolism in the heart, and has been implicated in various cardiovascular diseases, including heart failure and atherosclerosis. In conclusion, DDX5 is a multifunctional protein that plays a crucial role in various cellular processes, including RNA metabolism, transcription, and translation. Its expression is widely distributed across different cell types, and its dysregulation has been implicated in various diseases. Further studies are needed to fully understand the role of DDX5 in human health and disease.

Genular Protein ID: 1709874619

Symbol: DDX5_HUMAN

Name: Probable ATP-dependent RNA helicase DDX5

UniProtKB Accession Codes:

P17844 B4DLW8 B5BU21 D3DU32 E7ETL9 O75681 Q53Y61

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CTD 1 ChEBI 8 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 2 EMBL 11 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 47 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 5 RefSeq 3 Rhea 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2349099

Title: Complete cDNA sequence of the human p68 protein.

PubMed ID: 2349099

DOI: 10.1093/nar/18.10.3045

PubMed ID: 1996094

Title: p68 RNA helicase: identification of a nucleolar form and cloning of related genes containing a conserved intron in yeasts.

PubMed ID: 1996094

DOI: 10.1128/mcb.11.3.1326-1333.1991

PubMed ID: 10648785

Title: Structure and expression of the human p68 RNA helicase gene.

PubMed ID: 10648785

DOI: 10.1093/nar/28.4.932

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2451786

Title: Nuclear protein with sequence homology to translation initiation factor eIF-4A.

PubMed ID: 2451786

DOI: 10.1038/332736a0

PubMed ID: 10409727

Title: Purification and identification of p68 RNA helicase acting as a transcriptional coactivator specific for the activation function 1 of human estrogen receptor alpha.

PubMed ID: 10409727

DOI: 10.1128/mcb.19.8.5363

PubMed ID: 24509260

Title:

PubMed ID: 24509260

DOI: 10.1128/mcb.01458-13

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 22034099

Title: The DEAD-box RNA helicase DDX3 interacts with DDX5, co-localizes with it in the cytoplasm during the G2/M phase of the cycle, and affects its shuttling during mRNP export.

PubMed ID: 22034099

DOI: 10.1002/jcb.23428

PubMed ID: 10837141

Title: The nuclear DEAD box RNA helicase p68 interacts with the nucleolar protein fibrillarin and colocalizes specifically in nascent nucleoli during telophase.

PubMed ID: 10837141

DOI: 10.1006/excr.2000.4886

PubMed ID: 11250900

Title: A subfamily of RNA-binding DEAD-box proteins acts as an estrogen receptor alpha coactivator through the N-terminal activation domain (AF-1) with an RNA coactivator, SRA.

PubMed ID: 11250900

DOI: 10.1093/emboj/20.6.1341

PubMed ID: 25452582

Title:

PubMed ID: 25452582

DOI: 10.15252/embj.201470090

PubMed ID: 11991638

Title: Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.

PubMed ID: 11991638

DOI: 10.1017/s1355838202021088

PubMed ID: 12595555

Title: The highly related DEAD box RNA helicases p68 and p72 exist as heterodimers in cells.

PubMed ID: 12595555

DOI: 10.1093/nar/gkg236

PubMed ID: 12527917

Title: Synergism between p68 RNA helicase and the transcriptional coactivators CBP and p300.

PubMed ID: 12527917

DOI: 10.1038/sj.onc.1206067

PubMed ID: 15298701

Title: The p68 and p72 DEAD box RNA helicases interact with HDAC1 and repress transcription in a promoter-specific manner.

PubMed ID: 15298701

DOI: 10.1186/1471-2199-5-11

PubMed ID: 15660129

Title: The DEAD box protein p68: a novel transcriptional coactivator of the p53 tumour suppressor.

PubMed ID: 15660129

DOI: 10.1038/sj.emboj.7600550

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 17011493

Title: The RNA helicases p68/p72 and the noncoding RNA SRA are coregulators of MyoD and skeletal muscle differentiation.

PubMed ID: 17011493

DOI: 10.1016/j.devcel.2006.08.003

PubMed ID: 17932509

Title: Proteomic and functional analysis of Argonaute-containing mRNA-protein complexes in human cells.

PubMed ID: 17932509

DOI: 10.1038/sj.embor.7401088

PubMed ID: 17369852

Title: SUMO modification of the DEAD box protein p68 modulates its transcriptional activity and promotes its interaction with HDAC1.

PubMed ID: 17369852

DOI: 10.1038/sj.onc.1210387

PubMed ID: 18829551

Title: The RNA helicase p68 is a novel androgen receptor coactivator involved in splicing and is overexpressed in prostate cancer.

PubMed ID: 18829551

DOI: 10.1158/0008-5472.can-08-0932

PubMed ID: 18279852

Title: Transcription-dependent nucleolar cap localization and possible nuclear function of DExH RNA helicase RHAU.

PubMed ID: 18279852

DOI: 10.1016/j.yexcr.2008.01.006

PubMed ID: 17960593

Title: p68 (Ddx5) interacts with Runx2 and regulates osteoblast differentiation.

PubMed ID: 17960593

DOI: 10.1002/jcb.21526

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19718048

Title: The DEAD-box protein p72 regulates ERalpha-/oestrogen-dependent transcription and cell growth, and is associated with improved survival in ERalpha-positive breast cancer.

PubMed ID: 19718048

DOI: 10.1038/onc.2009.261

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 19995069

Title: Sumoylation of p68 and p72 RNA helicases affects protein stability and transactivation potential.

PubMed ID: 19995069

DOI: 10.1021/bi901263m

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21343338

Title: RNA helicase p68 (DDX5) regulates tau exon 10 splicing by modulating a stem-loop structure at the 5' splice site.

PubMed ID: 21343338

DOI: 10.1128/mcb.01149-10

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24644279

Title: Nuclear ARVCF protein binds splicing factors and contributes to the regulation of alternative splicing.

PubMed ID: 24644279

DOI: 10.1074/jbc.m113.530717

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 26030138

Title: Identification of Novel Proteins Co-Purifying with Cockayne Syndrome Group B (CSB) Reveals Potential Roles for CSB in RNA Metabolism and Chromatin Dynamics.

PubMed ID: 26030138

DOI: 10.1371/journal.pone.0128558

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 20941364

Title: Comparative structural analysis of human DEAD-box RNA helicases.

PubMed ID: 20941364

DOI: 10.1371/journal.pone.0012791

Sequence Information:

  • Length: 614
  • Mass: 69148
  • Checksum: 84DF684FD6871594
  • Sequence:
    • MSGYSSDRDR GRDRGFGAPR FGGSRAGPLS GKKFGNPGEK LVKKKWNLDE LPKFEKNFYQ 
EHPDLARRTA QEVETYRRSK EITVRGHNCP KPVLNFYEAN FPANVMDVIA RQNFTEPTAI 
QAQGWPVALS GLDMVGVAQT GSGKTLSYLL PAIVHINHQP FLERGDGPIC LVLAPTRELA 
QQVQQVAAEY CRACRLKSTC IYGGAPKGPQ IRDLERGVEI CIATPGRLID FLECGKTNLR 
RTTYLVLDEA DRMLDMGFEP QIRKIVDQIR PDRQTLMWSA TWPKEVRQLA EDFLKDYIHI 
NIGALELSAN HNILQIVDVC HDVEKDEKLI RLMEEIMSEK ENKTIVFVET KRRCDELTRK 
MRRDGWPAMG IHGDKSQQER DWVLNEFKHG KAPILIATDV ASRGLDVEDV KFVINYDYPN 
SSEDYIHRIG RTARSTKTGT AYTFFTPNNI KQVSDLISVL REANQAINPK LLQLVEDRGS 
GRSRGRGGMK DDRRDRYSAG KRGGFNTFRD RENYDRGYSS LLKRDFGAKT QNGVYSAANY 
TNGSFGSNFV SAGIQTSFRT GNPTGTYQNG YDSTQQYGSN VPNMHNGMNQ QAYAYPATAA 
APMIGYPMPT GYSQ

Genular Protein ID: 2703197575

Symbol: J3KTA4_HUMAN

Name: N/A

UniProtKB Accession Codes:

J3KTA4

Database IDs:

ARBA 13 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChEBI 5 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 7 Gene3D 1 GeneTree 1 HGNC 1 IntAct 1 InterPro 7 MINT 1 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 7 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 3 PhylomeDB 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 Rhea 1 RuleBase 1 SAM 1 SMART 3 SMR 1 SUPFAM 1 SwissPalm 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.O114.044792

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

Sequence Information:

  • Length: 614
  • Mass: 69087
  • Checksum: 015EB8FEC39957A2
  • Sequence:
    • MKAGRFEADE GTSVRFGAPR FGGSRAGPLS GKKFGNPGEK LVKKKWNLDE LPKFEKNFYQ 
EHPDLARRTA QEVETYRRSK EITVRGHNCP KPVLNFYEAN FPANVMDVIA RQNFTEPTAI 
QAQGWPVALS GLDMVGVAQT GSGKTLSYLL PAIVHINHQP FLERGDGPIC LVLAPTRELA 
QQVQQVAAEY CRACRLKSTC IYGGAPKGPQ IRDLERGVEI CIATPGRLID FLECGKTNLR 
RTTYLVLDEA DRMLDMGFEP QIRKIVDQIR PDRQTLMWSA TWPKEVRQLA EDFLKDYIHI 
NIGALELSAN HNILQIVDVC HDVEKDEKLI RLMEEIMSEK ENKTIVFVET KRRCDELTRK 
MRRDGWPAMG IHGDKSQQER DWVLNEFKHG KAPILIATDV ASRGLDVEDV KFVINYDYPN 
SSEDYIHRIG RTARSTKTGT AYTFFTPNNI KQVSDLISVL REANQAINPK LLQLVEDRGS 
GRSRGRGGMK DDRRDRYSAG KRGGFNTFRD RENYDRGYSS LLKRDFGAKT QNGVYSAANY 
TNGSFGSNFV SAGIQTSFRT GNPTGTYQNG YDSTQQYGSN VPNMHNGMNQ QAYAYPATAA 
APMIGYPMPT GYSQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.