Details for: HMGB1

Gene ID: 3146

Symbol: HMGB1

Ensembl ID: ENSG00000189403

Description: high mobility group box 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 5.19
    Marker Score: 4155
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 5.16
    Marker Score: 7945
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 4.86
    Marker Score: 1790
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 4.83
    Marker Score: 3647
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 4.68
    Marker Score: 46336
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 4.41
    Marker Score: 5749
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 4.37
    Marker Score: 58664
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 4.36
    Marker Score: 148360
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 4.26
    Marker Score: 56177
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 4.23
    Marker Score: 12343.5
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 4.19
    Marker Score: 8788
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 4.17
    Marker Score: 13147
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 4.12
    Marker Score: 1856.5
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 4.06
    Marker Score: 10326
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.04
    Marker Score: 9869
  • Cell Name: blood cell (CL0000081)
    Fold Change: 3.98
    Marker Score: 46305
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.98
    Marker Score: 950
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 3.96
    Marker Score: 10936
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 3.96
    Marker Score: 2407
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 3.92
    Marker Score: 207059
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 3.89
    Marker Score: 7096
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 3.79
    Marker Score: 10630
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.78
    Marker Score: 4038
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 3.77
    Marker Score: 3715.5
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 3.77
    Marker Score: 4188
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 3.76
    Marker Score: 2951.5
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 3.75
    Marker Score: 7051
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 3.73
    Marker Score: 3182
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 3.73
    Marker Score: 1211
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 3.71
    Marker Score: 2908
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 3.69
    Marker Score: 2676
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.68
    Marker Score: 205704
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 3.67
    Marker Score: 3551
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 3.67
    Marker Score: 2153
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 3.65
    Marker Score: 2763
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 3.64
    Marker Score: 944
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 3.61
    Marker Score: 3879
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 3.6
    Marker Score: 3031
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 3.59
    Marker Score: 26705
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 3.58
    Marker Score: 23323
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 3.57
    Marker Score: 5169
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 3.57
    Marker Score: 3185
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 3.55
    Marker Score: 1239
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 3.55
    Marker Score: 1615
  • Cell Name: theca cell (CL0000503)
    Fold Change: 3.55
    Marker Score: 2543
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 3.54
    Marker Score: 15162
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 3.51
    Marker Score: 3148
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 3.5
    Marker Score: 3300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.5
    Marker Score: 4222
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.49
    Marker Score: 22722
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 3.49
    Marker Score: 3791
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 3.48
    Marker Score: 2244
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 3.48
    Marker Score: 2477
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 3.48
    Marker Score: 810
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 3.47
    Marker Score: 20589
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 3.46
    Marker Score: 793
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 3.46
    Marker Score: 4081
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 3.45
    Marker Score: 2164
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 3.45
    Marker Score: 3334
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 3.45
    Marker Score: 4260
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 3.43
    Marker Score: 1764
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 3.42
    Marker Score: 829
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 3.39
    Marker Score: 5561
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 3.39
    Marker Score: 2244.5
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 3.37
    Marker Score: 8491
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 3.35
    Marker Score: 1785
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 3.34
    Marker Score: 4598
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 3.32
    Marker Score: 2512
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 3.31
    Marker Score: 1349
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 3.31
    Marker Score: 829
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 3.29
    Marker Score: 2900
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 3.29
    Marker Score: 5229
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 3.29
    Marker Score: 3850
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 3.28
    Marker Score: 2915
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 3.27
    Marker Score: 8777
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 3.27
    Marker Score: 2816
  • Cell Name: centroblast (CL0009112)
    Fold Change: 3.26
    Marker Score: 1608.5
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 3.26
    Marker Score: 2037.5
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 3.26
    Marker Score: 3730
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 3.26
    Marker Score: 1510
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 3.26
    Marker Score: 1356.5
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 3.25
    Marker Score: 1904
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 3.25
    Marker Score: 2136
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 3.24
    Marker Score: 925.5
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 3.24
    Marker Score: 1453
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 3.24
    Marker Score: 2806
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 3.23
    Marker Score: 6453.5
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 3.23
    Marker Score: 2027
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.22
    Marker Score: 111413
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 3.21
    Marker Score: 648
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 3.2
    Marker Score: 1598
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 3.19
    Marker Score: 846
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 3.19
    Marker Score: 2646
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 3.18
    Marker Score: 1111
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 3.18
    Marker Score: 16730
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 3.18
    Marker Score: 1372.5
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 3.18
    Marker Score: 3032
  • Cell Name: pericyte (CL0000669)
    Fold Change: 3.18
    Marker Score: 1857
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 3.17
    Marker Score: 4491
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 3.17
    Marker Score: 900

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Other Information

**Key characteristics:** * High mobility group box 1 (HMGB1) is a large protein with a molecular weight of approximately 130 kDa. * It is a highly conserved protein that is found in all eukaryotic cells. * HMGB1 is a chaperone protein that helps to fold and maintain the structure of DNA and RNA molecules. * It is also involved in the regulation of gene expression. * HMGB1 is involved in the immune response and is expressed in a wide range of cell types. **Pathways and functions:** * HMGB1 is involved in the adaptive immune response. It is expressed in high levels in cells that are activated during an immune response, such as macrophages and dendritic cells. * It helps to regulate the activation and differentiation of immune cells. * HMGB1 is also involved in the regulation of apoptosis. It is expressed in cells that are about to undergo apoptosis and helps to trigger the process. * It is also involved in the regulation of inflammation. * HMGB1 is a key regulator of cell cycle progression. It is expressed in cells that are in the G1 phase of the cell cycle and helps to promote the transition to the S phase. **Clinical significance:** HMGB1 is a potential therapeutic target for a variety of diseases. It is expressed in high levels in cancer cells and is involved in the regulation of cell cycle progression and apoptosis. Targeting HMGB1 with drugs could therefore be a potential way to inhibit cancer growth. HMGB1 is also involved in the regulation of inflammation. It is expressed in inflammatory cells and is involved in the production of inflammatory cytokines. Targeting HMGB1 with drugs could therefore be a potential way to reduce inflammation.

Genular Protein ID: 3810735176

Symbol: HMGB1_HUMAN

Name: High mobility group protein B1

UniProtKB Accession Codes:

P09429 A5D8W9 Q14321 Q5T7C3 Q6IBE1

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CTD 1 ChEBI 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DOSAC-COBS-2DPAGE 1 DisGeNET 1 DisProt 1 DrugBank 2 EMBL 19 EMDB 5 EPD 1 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 90 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 MoonProt 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PCDDB 1 PDB 14 PDBsum 11 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 11 RefSeq 3 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 4 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2922262

Title: A human placental cDNA clone that encodes nonhistone chromosomal protein HMG-1.

PubMed ID: 2922262

DOI: 10.1093/nar/17.3.1197

PubMed ID: 8661151

Title: The active gene that encodes human high mobility group 1 protein (HMG1) contains introns and maps to chromosome 13.

PubMed ID: 8661151

DOI: 10.1006/geno.1996.0369

PubMed ID: 9036861

Title: Expression of high-mobility group-1 mRNA in human gastrointestinal adenocarcinoma and corresponding non-cancerous mucosa.

PubMed ID: 9036861

DOI: 10.1002/(sici)1097-0215(19970220)74:1<1::aid-ijc1>3.0.co;2-6

PubMed ID: 17610420

Title: The genetic variation of the human HMGB1 gene.

PubMed ID: 17610420

DOI: 10.1111/j.1399-0039.2007.00854.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9150946

Title: Two-dimensional electrophoretic analysis of human breast carcinoma proteins: mapping of proteins that bind to the SH3 domain of mixed lineage kinase MLK2.

PubMed ID: 9150946

DOI: 10.1002/elps.1150180342

PubMed ID: 11154118

Title: Occurrence of amphoterin (HMG1) as an endogenous protein of human platelets that is exported to the cell surface upon platelet activation.

PubMed ID: 11154118

PubMed ID: 12231511

Title: The nuclear protein HMGB1 is secreted by monocytes via a non-classical, vesicle-mediated secretory pathway.

PubMed ID: 12231511

DOI: 10.1093/embo-reports/kvf198

PubMed ID: 14532127

Title: Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion.

PubMed ID: 14532127

DOI: 10.1093/emboj/cdg516

PubMed ID: 12765338

Title: Structural basis for the proinflammatory cytokine activity of high mobility group box 1.

PubMed ID: 12765338

DOI: 10.1007/bf03402105

PubMed ID: 15014079

Title: Evidence for involvement of HMGB1 protein in human DNA mismatch repair.

PubMed ID: 15014079

DOI: 10.1074/jbc.m401931200

PubMed ID: 14695889

Title: Reversing established sepsis with antagonists of endogenous high-mobility group box 1.

PubMed ID: 14695889

DOI: 10.1073/pnas.2434651100

PubMed ID: 16143102

Title: Reconstitution of 5'-directed human mismatch repair in a purified system.

PubMed ID: 16143102

DOI: 10.1016/j.cell.2005.06.027

PubMed ID: 15841214

Title: The N-terminal domain of thrombomodulin sequesters high-mobility group-B1 protein, a novel antiinflammatory mechanism.

PubMed ID: 15841214

DOI: 10.1172/jci22782

PubMed ID: 15944249

Title: Release of high mobility group box 1 by dendritic cells controls T cell activation via the receptor for advanced glycation end products.

PubMed ID: 15944249

DOI: 10.4049/jimmunol.174.12.7506

PubMed ID: 15607795

Title: Monocytes promote natural killer cell interferon gamma production in response to the endogenous danger signal HMGB1.

PubMed ID: 15607795

DOI: 10.1016/j.molimm.2004.07.023

PubMed ID: 16855214

Title: The extracellular release of HMGB1 during apoptotic cell death.

PubMed ID: 16855214

DOI: 10.1152/ajpcell.00616.2005

PubMed ID: 16962095

Title: Molecular basis for the redox control of nuclear transport of the structural chromatin protein Hmgb1.

PubMed ID: 16962095

DOI: 10.1016/j.yexcr.2006.07.020

PubMed ID: 17114460

Title: Nucleocytoplasmic shuttling of HMGB1 is regulated by phosphorylation that redirects it toward secretion.

PubMed ID: 17114460

DOI: 10.4049/jimmunol.177.11.7889

PubMed ID: 18631454

Title: Induction of immunological tolerance by apoptotic cells requires caspase-dependent oxidation of high-mobility group box-1 protein.

PubMed ID: 18631454

DOI: 10.1016/j.immuni.2008.05.013

PubMed ID: 17803946

Title: HMGB1 is a cofactor in mammalian base excision repair.

PubMed ID: 17803946

DOI: 10.1016/j.molcel.2007.06.029

PubMed ID: 19064698

Title: Induction of inflammatory and immune responses by HMGB1-nucleosome complexes: implications for the pathogenesis of SLE.

PubMed ID: 19064698

DOI: 10.1084/jem.20081165

PubMed ID: 18250463

Title: HMGB1 develops enhanced proinflammatory activity by binding to cytokines.

PubMed ID: 18250463

DOI: 10.4049/jimmunol.180.4.2531

PubMed ID: 18354232

Title: High mobility group box 1 protein binding to lipopolysaccharide facilitates transfer of lipopolysaccharide to CD14 and enhances lipopolysaccharide-mediated TNF-alpha production in human monocytes.

PubMed ID: 18354232

DOI: 10.4049/jimmunol.180.7.5067

PubMed ID: 18160415

Title: Proteomic screen defines the hepatocyte nuclear factor 1alpha-binding partners and identifies HMGB1 as a new cofactor of HNF1alpha.

PubMed ID: 18160415

DOI: 10.1093/nar/gkm1131

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19811284

Title: Oxidation of the alarmin high-mobility group box 1 protein (HMGB1) during apoptosis.

PubMed ID: 19811284

DOI: 10.1080/08916930902831803

PubMed ID: 19446504

Title: Human HMGB1 directly facilitates interactions between nucleotide excision repair proteins on triplex-directed psoralen interstrand crosslinks.

PubMed ID: 19446504

DOI: 10.1016/j.dnarep.2009.04.001

PubMed ID: 19360789

Title: HMGB1: the jack-of-all-trades protein is a master DNA repair mechanic.

PubMed ID: 19360789

DOI: 10.1002/mc.20544

PubMed ID: 19264983

Title: CD24 and Siglec-10 selectively repress tissue damage-induced immune responses.

PubMed ID: 19264983

DOI: 10.1126/science.1168988

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20123072

Title: HMGB proteins: interactions with DNA and chromatin.

PubMed ID: 20123072

DOI: 10.1016/j.bbagrm.2009.09.008

PubMed ID: 20819940

Title: Endogenous HMGB1 regulates autophagy.

PubMed ID: 20819940

DOI: 10.1083/jcb.200911078

PubMed ID: 20547845

Title: A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release.

PubMed ID: 20547845

DOI: 10.1073/pnas.1003893107

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21395369

Title: High mobility group box 1 (HMGB1) activates an autophagic response to oxidative stress.

PubMed ID: 21395369

DOI: 10.1089/ars.2010.3666

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21660935

Title: Identification of lipopolysaccharide-binding peptide regions within HMGB1 and their effects on subclinical endotoxemia in a mouse model.

PubMed ID: 21660935

DOI: 10.1002/eji.201141391

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22696656

Title: HMGB1 protein binds to influenza virus nucleoprotein and promotes viral replication.

PubMed ID: 22696656

DOI: 10.1128/jvi.00789-12

PubMed ID: 22473704

Title: HMGB1 conveys immunosuppressive characteristics on regulatory and conventional T cells.

PubMed ID: 22473704

DOI: 10.1093/intimm/dxs051

PubMed ID: 22370717

Title: HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4.

PubMed ID: 22370717

DOI: 10.1084/jem.20111739

PubMed ID: 22869893

Title: Mutually exclusive redox forms of HMGB1 promote cell recruitment or proinflammatory cytokine release.

PubMed ID: 22869893

DOI: 10.1084/jem.20120189

PubMed ID: 22801494

Title: Novel role of PKR in inflammasome activation and HMGB1 release.

PubMed ID: 22801494

DOI: 10.1038/nature11290

PubMed ID: 23040637

Title: High mobility group box 1 released from necrotic cells enhances regrowth and metastasis of cancer cells that have survived chemotherapy.

PubMed ID: 23040637

DOI: 10.1016/j.ejca.2012.09.016

PubMed ID: 23519706

Title: HMGB1: The central cytokine for all lymphoid cells.

PubMed ID: 23519706

DOI: 10.3389/fimmu.2013.00068

PubMed ID: 23303669

Title: Chaperone-like activity of high-mobility group box 1 protein and its role in reducing the formation of polyglutamine aggregates.

PubMed ID: 23303669

DOI: 10.4049/jimmunol.1202472

PubMed ID: 23446148

Title: The many faces of HMGB1: molecular structure-functional activity in inflammation, apoptosis, and chemotaxis.

PubMed ID: 23446148

DOI: 10.1189/jlb.1212662

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23994764

Title: Menage a Trois in stress: DAMPs, redox and autophagy.

PubMed ID: 23994764

DOI: 10.1016/j.semcancer.2013.08.002

PubMed ID: 24971542

Title: HMGB1-DNA complex-induced autophagy limits AIM2 inflammasome activation through RAGE.

PubMed ID: 24971542

DOI: 10.1016/j.bbrc.2014.06.074

PubMed ID: 24474694

Title: An immunogenic peptide in the A-box of HMGB1 protein reverses apoptosis-induced tolerance through RAGE receptor.

PubMed ID: 24474694

DOI: 10.1074/jbc.m113.541474

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24531895

Title: A systematic nomenclature for the redox states of high mobility group box (HMGB) proteins.

PubMed ID: 24531895

DOI: 10.2119/molmed.2014.00022

PubMed ID: 24220159

Title: An overview on HMGB1 inhibitors as potential therapeutic agents in HMGB1-related pathologies.

PubMed ID: 24220159

DOI: 10.1016/j.pharmthera.2013.11.001

PubMed ID: 25549101

Title: Role of high mobility group box 1 (HMGB1) in SCA17 pathogenesis.

PubMed ID: 25549101

DOI: 10.1371/journal.pone.0115809

PubMed ID: 25048472

Title: The role of high mobility group box 1 in innate immunity.

PubMed ID: 25048472

DOI: 10.3349/ymj.2014.55.5.1165

PubMed ID: 26078984

Title: HMGB1 promotes systemic lupus erythematosus by enhancing macrophage inflammatory response.

PubMed ID: 26078984

DOI: 10.1155/2015/946748

PubMed ID: 25660311

Title: HMGB1 binds to lipoteichoic acid and enhances TNF-alpha and IL-6 production through HMGB1-mediated transfer of lipoteichoic acid to CD14 and TLR2.

PubMed ID: 25660311

DOI: 10.1159/000369972

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27362237

Title: A core viral protein binds host nucleosomes to sequester immune danger signals.

PubMed ID: 27362237

DOI: 10.1038/nature18317

PubMed ID: 28190768

Title: Serine ADP-ribosylation depends on HPF1.

PubMed ID: 28190768

DOI: 10.1016/j.molcel.2017.01.003

PubMed ID: 29618516

Title: The proinflammatory protein HMGB1 is a substrate of transglutaminase-2 and forms high-molecular weight complexes with autoantigens.

PubMed ID: 29618516

DOI: 10.1074/jbc.ra117.001078

PubMed ID: 33147444

Title: Genome-wide CRISPR Screens Reveal Host Factors Critical for SARS-CoV-2 Infection.

PubMed ID: 33147444

DOI: 10.1016/j.cell.2020.10.028

PubMed ID: 34743181

Title: LPS-induced macrophage HMGB1-loaded extracellular vesicles trigger hepatocyte pyroptosis by activating the NLRP3 inflammasome.

PubMed ID: 34743181

DOI: 10.1038/s41420-021-00729-0

PubMed ID: 34922257

Title: The danger molecule HMGB1 cooperates with the NLRP3 inflammasome to sustain expression of the EBV lytic switch protein in Burkitt lymphoma cells.

PubMed ID: 34922257

DOI: 10.1016/j.virol.2021.12.002

PubMed ID: 36585612

Title: USP13 regulates HMGB1 stability and secretion through its deubiquitinase activity.

PubMed ID: 36585612

DOI: 10.1186/s10020-022-00596-0

PubMed ID: 34971702

Title: High-mobility group box 1 protein promotes dengue virus replication by interacting with untranslated regions of viral genome.

PubMed ID: 34971702

DOI: 10.1016/j.virusres.2021.198668

PubMed ID: 35239449

Title: SARS-CoV-2 ORF3a induces RETREG1/FAM134B-dependent reticulophagy and triggers sequential ER stress and inflammatory responses during SARS-CoV-2 infection.

PubMed ID: 35239449

DOI: 10.1080/15548627.2022.2039992

PubMed ID: 23063560

Title: HMGB1-facilitated p53 DNA binding occurs via HMG-Box/p53 transactivation domain interaction, regulated by the acidic tail.

PubMed ID: 23063560

DOI: 10.1016/j.str.2012.09.004

PubMed ID: 24427810

Title: Redox-sensitive structural change in the A-domain of HMGB1 and its implication for the binding to cisplatin modified DNA.

PubMed ID: 24427810

DOI: 10.1016/j.bbrc.2013.10.085

Sequence Information:

  • Length: 215
  • Mass: 24894
  • Checksum: 8A868CF277D417B5
  • Sequence:
    • MGKGDPKKPR GKMSSYAFFV QTCREEHKKK HPDASVNFSE FSKKCSERWK TMSAKEKGKF 
EDMAKADKAR YEREMKTYIP PKGETKKKFK DPNAPKRPPS AFFLFCSEYR PKIKGEHPGL 
SIGDVAKKLG EMWNNTAADD KQPYEKKAAK LKEKYEKDIA AYRAKGKPDA AKKGVVKAEK 
SKKKKEEEED EEDEEDEEEE EDEEDEDEEE DDDDE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.