HMGB1 | ENSG00000189403 | NCBI 3146

Details for: HMGB1

Gene ID: 3146

Symbol: HMGB1

Ensembl ID: ENSG00000189403

Description: high mobility group box 1

Associated with

Adaptive immune system
(R-HSA-1280218)
Advanced glycosylation endproduct receptor signaling
(R-HSA-879415)
Antigen processing-cross presentation
(R-HSA-1236975)
Apoptosis
(R-HSA-109581)
Apoptosis induced dna fragmentation
(R-HSA-140342)
Apoptotic execution phase
(R-HSA-75153)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Cytokine signaling in immune system
(R-HSA-1280215)
Ddx58/ifih1-mediated induction of interferon-alpha/beta
(R-HSA-168928)
Disease
(R-HSA-1643685)
Diseases associated with the tlr signaling cascade
(R-HSA-5602358)
Diseases of immune system
(R-HSA-5260271)
Er-phagosome pathway
(R-HSA-1236974)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Interleukin-1 family signaling
(R-HSA-446652)
Interleukin-1 signaling
(R-HSA-9020702)
Irak4 deficiency (tlr2/4)
(R-HSA-5603041)
Myd88 cascade initiated on plasma membrane
(R-HSA-975871)
Myd88 deficiency (tlr2/4)
(R-HSA-5602498)
Myd88 dependent cascade initiated on endosome
(R-HSA-975155)
Myd88-independent tlr4 cascade
(R-HSA-166166)
Myd88:mal(tirap) cascade initiated on plasma membrane
(R-HSA-166058)
Neutrophil degranulation
(R-HSA-6798695)
Programmed cell death
(R-HSA-5357801)
Pyroptosis
(R-HSA-5620971)
Regulated necrosis
(R-HSA-5218859)
Regulation of tlr by endogenous ligand
(R-HSA-5686938)
Signaling by interleukins
(R-HSA-449147)
Tak1-dependent ikk and nf-kappa-b activation
(R-HSA-445989)
Toll-like receptor cascades
(R-HSA-168898)
Toll like receptor 2 (tlr2) cascade
(R-HSA-181438)
Toll like receptor 3 (tlr3) cascade
(R-HSA-168164)
Toll like receptor 4 (tlr4) cascade
(R-HSA-166016)
Toll like receptor 5 (tlr5) cascade
(R-HSA-168176)
Toll like receptor 7/8 (tlr7/8) cascade
(R-HSA-168181)
Toll like receptor 9 (tlr9) cascade
(R-HSA-168138)
Toll like receptor 10 (tlr10) cascade
(R-HSA-168142)
Toll like receptor tlr1:tlr2 cascade
(R-HSA-168179)
Toll like receptor tlr6:tlr2 cascade
(R-HSA-168188)
Traf6 mediated induction of nfkb and map kinases upon tlr7/8 or 9 activation
(R-HSA-975138)
Traf6 mediated nf-kb activation
(R-HSA-933542)
Trif(ticam1)-mediated tlr4 signaling
(R-HSA-937061)
Activation of innate immune response
(GO:0002218)
Autophagy
(GO:0006914)
Bubble dna binding
(GO:0000405)
C-x-c chemokine binding
(GO:0019958)
Chemoattractant activity
(GO:0042056)
Cytokine activity
(GO:0005125)
Damaged dna binding
(GO:0003684)
Dendritic cell chemotaxis
(GO:0002407)
Dna-binding transcription factor binding
(GO:0140297)
Dna binding, bending
(GO:0008301)
Dna geometric change
(GO:0032392)
Dna polymerase binding
(GO:0070182)
Dna recombination
(GO:0006310)
Dna topological change
(GO:0006265)
Double-strand break repair via nonhomologous end joining
(GO:0006303)
Double-stranded dna binding
(GO:0003690)
Four-way junction dna binding
(GO:0000400)
Heterochromatin formation
(GO:0031507)
Inflammatory response
(GO:0006954)
Inflammatory response to antigenic stimulus
(GO:0002437)
Integrin binding
(GO:0005178)
Lipopolysaccharide binding
(GO:0001530)
Lyase activity
(GO:0016829)
Myeloid dendritic cell activation
(GO:0001773)
Negative regulation of rna polymerase ii transcription preinitiation complex assembly
(GO:0017055)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Negative regulation of type ii interferon production
(GO:0032689)
Neuron projection development
(GO:0031175)
Phosphatidylserine binding
(GO:0001786)
Positive regulation of autophagy
(GO:0010508)
Positive regulation of cytosolic calcium ion concentration
(GO:0007204)
Positive regulation of interleukin-1 production
(GO:0032732)
Positive regulation of interleukin-6 production
(GO:0032755)
Positive regulation of interleukin-8 production
(GO:0032757)
Positive regulation of interleukin-10 production
(GO:0032733)
Positive regulation of interleukin-12 production
(GO:0032735)
Positive regulation of mismatch repair
(GO:0032425)
Positive regulation of tumor necrosis factor production
(GO:0032760)
Protein binding
(GO:0005515)
Rage receptor binding
(GO:0050786)
Receptor ligand activity
(GO:0048018)
Regulation of restriction endodeoxyribonuclease activity
(GO:0032072)
Regulation of t cell mediated immune response to tumor cell
(GO:0002840)
Regulation of tolerance induction
(GO:0002643)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rna binding
(GO:0003723)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Signal transduction
(GO:0007165)
Single-stranded dna binding
(GO:0003697)
Supercoiled dna binding
(GO:0097100)
Transcription cis-regulatory region binding
(GO:0000976)
Transcription coactivator activity
(GO:0003713)
Transcription corepressor activity
(GO:0003714)
V(d)j recombination
(GO:0033151)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: early promyelocyte (CL0002154)
Fold Change: 5.19