Details for: HMGB1

Gene ID: 3146

Symbol: HMGB1

Ensembl ID: ENSG00000189403

Description: high mobility group box 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 1026.4217
    Cell Significance Index: -159.6600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 717.5034
    Cell Significance Index: -181.9900
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 564.8291
    Cell Significance Index: -232.6800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 516.2494
    Cell Significance Index: -209.7300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 501.0139
    Cell Significance Index: -236.5400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 447.1162
    Cell Significance Index: -229.9900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 354.5114
    Cell Significance Index: -237.8900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 176.5838
    Cell Significance Index: -217.7200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 59.3087
    Cell Significance Index: -234.0400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 55.2922
    Cell Significance Index: -148.1200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 52.6526
    Cell Significance Index: -161.7200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 36.4710
    Cell Significance Index: -79.8200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 10.5984
    Cell Significance Index: 368.2900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 7.0830
    Cell Significance Index: 835.3000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 6.9641
    Cell Significance Index: 449.2900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 5.9441
    Cell Significance Index: 124.4200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 5.7928
    Cell Significance Index: 152.3200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 5.6359
    Cell Significance Index: 773.9700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 5.0987
    Cell Significance Index: 55.4300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 4.9257
    Cell Significance Index: 605.6700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 4.9034
    Cell Significance Index: 2167.9200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 4.5456
    Cell Significance Index: 819.4300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 4.2999
    Cell Significance Index: 225.7600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 4.1705
    Cell Significance Index: 534.6400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 4.1336
    Cell Significance Index: 194.2800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 4.1232
    Cell Significance Index: 2251.7900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 4.0657
    Cell Significance Index: 287.5400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.3932
    Cell Significance Index: 92.3600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 3.2069
    Cell Significance Index: 74.0900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 2.9198
    Cell Significance Index: 33.1700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.7030
    Cell Significance Index: 201.4500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.6263
    Cell Significance Index: 75.2900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.5912
    Cell Significance Index: 929.4000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.0493
    Cell Significance Index: 264.7500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.7633
    Cell Significance Index: 98.9500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.6986
    Cell Significance Index: 340.7400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.4690
    Cell Significance Index: 291.5200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.4216
    Cell Significance Index: 87.3800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.2890
    Cell Significance Index: 140.2100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.0739
    Cell Significance Index: 50.0700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.0596
    Cell Significance Index: 31.1200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.9669
    Cell Significance Index: 668.7300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6910
    Cell Significance Index: 31.3200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.6028
    Cell Significance Index: 102.9400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.5416
    Cell Significance Index: 409.9900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.2817
    Cell Significance Index: 206.5400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2601
    Cell Significance Index: 489.7500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1724
    Cell Significance Index: 2.8900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1231
    Cell Significance Index: 23.4200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1080
    Cell Significance Index: 199.2700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0690
    Cell Significance Index: 106.2500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0364
    Cell Significance Index: 49.4700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0226
    Cell Significance Index: 1.7400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0082
    Cell Significance Index: 0.2200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0873
    Cell Significance Index: -55.4200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1204
    Cell Significance Index: -89.2200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1433
    Cell Significance Index: -89.5100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1770
    Cell Significance Index: -18.0800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2037
    Cell Significance Index: -3.7600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.2600
    Cell Significance Index: -118.0200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.3223
    Cell Significance Index: -181.7700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.4164
    Cell Significance Index: -41.2000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.4380
    Cell Significance Index: -15.3900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.5576
    Cell Significance Index: -117.4500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.5779
    Cell Significance Index: -16.1500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.5888
    Cell Significance Index: -10.4100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.7273
    Cell Significance Index: -37.7800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.7302
    Cell Significance Index: -210.1000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -1.0248
    Cell Significance Index: -148.9600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.3230
    Cell Significance Index: -42.3800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -1.3536
    Cell Significance Index: -17.3400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -1.3797
    Cell Significance Index: -160.7900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.3822
    Cell Significance Index: -92.9400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -1.4372
    Cell Significance Index: -164.0500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.4396
    Cell Significance Index: -114.0200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -1.4456
    Cell Significance Index: -36.9300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -1.4549
    Cell Significance Index: -166.6800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -1.4851
    Cell Significance Index: -42.7900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.5263
    Cell Significance Index: -67.5100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.7652
    Cell Significance Index: -30.2500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.8581
    Cell Significance Index: -117.1100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -2.0487
    Cell Significance Index: -213.3200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -2.1913
    Cell Significance Index: -82.9800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -2.3827
    Cell Significance Index: -59.5600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -2.4298
    Cell Significance Index: -22.3800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -2.4700
    Cell Significance Index: -170.8200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -2.6502
    Cell Significance Index: -21.1600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -2.7312
    Cell Significance Index: -163.9700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -3.4992
    Cell Significance Index: -83.9200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -3.5036
    Cell Significance Index: -90.0600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -3.6065
    Cell Significance Index: -54.0400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -3.8267
    Cell Significance Index: -234.6100
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -3.9648
    Cell Significance Index: -30.5600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -4.0285
    Cell Significance Index: -209.8400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -4.2033
    Cell Significance Index: -112.4400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -4.2745
    Cell Significance Index: -58.3200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -4.5516
    Cell Significance Index: -98.6100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -4.5821
    Cell Significance Index: -97.5900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -4.7647
    Cell Significance Index: -135.9700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -4.8176
    Cell Significance Index: -141.9000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Nuclear protein**: HMGB1 is a member of the high mobility group (HMG) family of proteins, which are known for their ability to bind DNA and regulate gene expression. 2. **Extracellular release**: Upon cell death or activation, HMGB1 can be released into the extracellular environment, where it acts as a pro-inflammatory cytokine. 3. **Multifunctional**: HMGB1 has been implicated in various cellular processes, including DNA repair, transcriptional regulation, and protein binding. 4. **Pro-inflammatory**: HMGB1 promotes inflammation by stimulating the production of pro-inflammatory cytokines and chemokines. **Pathways and Functions:** 1. **Innate Immunity**: HMGB1 is released by damaged or dying cells, triggering the innate immune response and activating pattern recognition receptors (PRRs) such as TLR4 and TLR9. 2. **Adaptive Immunity**: HMGB1 can also modulate the adaptive immune response by influencing T cell activation and cytokine production. 3. **Apoptosis**: HMGB1 has been shown to induce apoptosis in various cell types, including cancer cells. 4. **Autophagy**: HMGB1 promotes autophagy, a cellular process involved in the degradation and recycling of damaged organelles and proteins. 5. **Transcriptional regulation**: HMGB1 binds to DNA and regulates gene expression by interacting with transcription factors and co-regulators. **Clinical Significance:** 1. **Inflammatory diseases**: HMGB1 has been implicated in various inflammatory diseases, including rheumatoid arthritis, atherosclerosis, and cancer. 2. **Infectious diseases**: HMGB1 plays a critical role in the clearance of infections, particularly those caused by bacteria and viruses. 3. **Autoimmune diseases**: HMGB1 has been linked to autoimmune diseases, such as multiple sclerosis and lupus. 4. **Cancer**: HMGB1 is overexpressed in many types of cancer, where it promotes tumor growth, invasion, and metastasis. 5. **Regenerative medicine**: HMGB1 has been explored as a potential therapeutic target for tissue repair and regeneration. In conclusion, HMGB1 is a multifaceted protein that plays a critical role in the immune system, with implications for both innate and adaptive immunity. Its dysregulation has been implicated in various diseases, making it an attractive target for therapeutic intervention. Further research is necessary to fully understand the complex mechanisms underlying HMGB1's functions and to explore its potential as a therapeutic agent.

Genular Protein ID: 3810735176

Symbol: HMGB1_HUMAN

Name: High mobility group protein B1

UniProtKB Accession Codes:

P09429 A5D8W9 Q14321 Q5T7C3 Q6IBE1

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CTD 1 ChEBI 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 2 DrugCentral 1 EMBL 19 EMDB 6 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 90 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 MoonProt 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PCDDB 1 PDB 12 PDBsum 12 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 11 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2922262

Title: A human placental cDNA clone that encodes nonhistone chromosomal protein HMG-1.

PubMed ID: 2922262

DOI: 10.1093/nar/17.3.1197

PubMed ID: 8661151

Title: The active gene that encodes human high mobility group 1 protein (HMG1) contains introns and maps to chromosome 13.

PubMed ID: 8661151

DOI: 10.1006/geno.1996.0369

PubMed ID: 9036861

Title: Expression of high-mobility group-1 mRNA in human gastrointestinal adenocarcinoma and corresponding non-cancerous mucosa.

PubMed ID: 9036861

DOI: 10.1002/(sici)1097-0215(19970220)74:1<1::aid-ijc1>3.0.co;2-6

PubMed ID: 17610420

Title: The genetic variation of the human HMGB1 gene.

PubMed ID: 17610420

DOI: 10.1111/j.1399-0039.2007.00854.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9150946

Title: Two-dimensional electrophoretic analysis of human breast carcinoma proteins: mapping of proteins that bind to the SH3 domain of mixed lineage kinase MLK2.

PubMed ID: 9150946

DOI: 10.1002/elps.1150180342

PubMed ID: 11154118

Title: Occurrence of amphoterin (HMG1) as an endogenous protein of human platelets that is exported to the cell surface upon platelet activation.

PubMed ID: 11154118

PubMed ID: 12231511

Title: The nuclear protein HMGB1 is secreted by monocytes via a non-classical, vesicle-mediated secretory pathway.

PubMed ID: 12231511

DOI: 10.1093/embo-reports/kvf198

PubMed ID: 14532127

Title: Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion.

PubMed ID: 14532127

DOI: 10.1093/emboj/cdg516

PubMed ID: 12765338

Title: Structural basis for the proinflammatory cytokine activity of high mobility group box 1.

PubMed ID: 12765338

DOI: 10.1007/bf03402105

PubMed ID: 15014079

Title: Evidence for involvement of HMGB1 protein in human DNA mismatch repair.

PubMed ID: 15014079

DOI: 10.1074/jbc.m401931200

PubMed ID: 14695889

Title: Reversing established sepsis with antagonists of endogenous high-mobility group box 1.

PubMed ID: 14695889

DOI: 10.1073/pnas.2434651100

PubMed ID: 16143102

Title: Reconstitution of 5'-directed human mismatch repair in a purified system.

PubMed ID: 16143102

DOI: 10.1016/j.cell.2005.06.027

PubMed ID: 15841214

Title: The N-terminal domain of thrombomodulin sequesters high-mobility group-B1 protein, a novel antiinflammatory mechanism.

PubMed ID: 15841214

DOI: 10.1172/jci22782

PubMed ID: 15944249

Title: Release of high mobility group box 1 by dendritic cells controls T cell activation via the receptor for advanced glycation end products.

PubMed ID: 15944249

DOI: 10.4049/jimmunol.174.12.7506

PubMed ID: 15607795

Title: Monocytes promote natural killer cell interferon gamma production in response to the endogenous danger signal HMGB1.

PubMed ID: 15607795

DOI: 10.1016/j.molimm.2004.07.023

PubMed ID: 16855214

Title: The extracellular release of HMGB1 during apoptotic cell death.

PubMed ID: 16855214

DOI: 10.1152/ajpcell.00616.2005

PubMed ID: 16962095

Title: Molecular basis for the redox control of nuclear transport of the structural chromatin protein Hmgb1.

PubMed ID: 16962095

DOI: 10.1016/j.yexcr.2006.07.020

PubMed ID: 17114460

Title: Nucleocytoplasmic shuttling of HMGB1 is regulated by phosphorylation that redirects it toward secretion.

PubMed ID: 17114460

DOI: 10.4049/jimmunol.177.11.7889

PubMed ID: 18631454

Title: Induction of immunological tolerance by apoptotic cells requires caspase-dependent oxidation of high-mobility group box-1 protein.

PubMed ID: 18631454

DOI: 10.1016/j.immuni.2008.05.013

PubMed ID: 17803946

Title: HMGB1 is a cofactor in mammalian base excision repair.

PubMed ID: 17803946

DOI: 10.1016/j.molcel.2007.06.029

PubMed ID: 19064698

Title: Induction of inflammatory and immune responses by HMGB1-nucleosome complexes: implications for the pathogenesis of SLE.

PubMed ID: 19064698

DOI: 10.1084/jem.20081165

PubMed ID: 18250463

Title: HMGB1 develops enhanced proinflammatory activity by binding to cytokines.

PubMed ID: 18250463

DOI: 10.4049/jimmunol.180.4.2531

PubMed ID: 18354232

Title: High mobility group box 1 protein binding to lipopolysaccharide facilitates transfer of lipopolysaccharide to CD14 and enhances lipopolysaccharide-mediated TNF-alpha production in human monocytes.

PubMed ID: 18354232

DOI: 10.4049/jimmunol.180.7.5067

PubMed ID: 18160415

Title: Proteomic screen defines the hepatocyte nuclear factor 1alpha-binding partners and identifies HMGB1 as a new cofactor of HNF1alpha.

PubMed ID: 18160415

DOI: 10.1093/nar/gkm1131

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19811284

Title: Oxidation of the alarmin high-mobility group box 1 protein (HMGB1) during apoptosis.

PubMed ID: 19811284

DOI: 10.1080/08916930902831803

PubMed ID: 19446504

Title: Human HMGB1 directly facilitates interactions between nucleotide excision repair proteins on triplex-directed psoralen interstrand crosslinks.

PubMed ID: 19446504

DOI: 10.1016/j.dnarep.2009.04.001

PubMed ID: 19360789

Title: HMGB1: the jack-of-all-trades protein is a master DNA repair mechanic.

PubMed ID: 19360789

DOI: 10.1002/mc.20544

PubMed ID: 19264983

Title: CD24 and Siglec-10 selectively repress tissue damage-induced immune responses.

PubMed ID: 19264983

DOI: 10.1126/science.1168988

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20123072

Title: HMGB proteins: interactions with DNA and chromatin.

PubMed ID: 20123072

DOI: 10.1016/j.bbagrm.2009.09.008

PubMed ID: 20819940

Title: Endogenous HMGB1 regulates autophagy.

PubMed ID: 20819940

DOI: 10.1083/jcb.200911078

PubMed ID: 20547845

Title: A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release.

PubMed ID: 20547845

DOI: 10.1073/pnas.1003893107

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21395369

Title: High mobility group box 1 (HMGB1) activates an autophagic response to oxidative stress.

PubMed ID: 21395369

DOI: 10.1089/ars.2010.3666

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21660935

Title: Identification of lipopolysaccharide-binding peptide regions within HMGB1 and their effects on subclinical endotoxemia in a mouse model.

PubMed ID: 21660935

DOI: 10.1002/eji.201141391

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22696656

Title: HMGB1 protein binds to influenza virus nucleoprotein and promotes viral replication.

PubMed ID: 22696656

DOI: 10.1128/jvi.00789-12

PubMed ID: 22473704

Title: HMGB1 conveys immunosuppressive characteristics on regulatory and conventional T cells.

PubMed ID: 22473704

DOI: 10.1093/intimm/dxs051

PubMed ID: 22370717

Title: HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4.

PubMed ID: 22370717

DOI: 10.1084/jem.20111739

PubMed ID: 22869893

Title: Mutually exclusive redox forms of HMGB1 promote cell recruitment or proinflammatory cytokine release.

PubMed ID: 22869893

DOI: 10.1084/jem.20120189

PubMed ID: 22801494

Title: Novel role of PKR in inflammasome activation and HMGB1 release.

PubMed ID: 22801494

DOI: 10.1038/nature11290

PubMed ID: 23040637

Title: High mobility group box 1 released from necrotic cells enhances regrowth and metastasis of cancer cells that have survived chemotherapy.

PubMed ID: 23040637

DOI: 10.1016/j.ejca.2012.09.016

PubMed ID: 23519706

Title: HMGB1: The central cytokine for all lymphoid cells.

PubMed ID: 23519706

DOI: 10.3389/fimmu.2013.00068

PubMed ID: 23303669

Title: Chaperone-like activity of high-mobility group box 1 protein and its role in reducing the formation of polyglutamine aggregates.

PubMed ID: 23303669

DOI: 10.4049/jimmunol.1202472

PubMed ID: 23446148

Title: The many faces of HMGB1: molecular structure-functional activity in inflammation, apoptosis, and chemotaxis.

PubMed ID: 23446148

DOI: 10.1189/jlb.1212662

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23994764

Title: Menage a Trois in stress: DAMPs, redox and autophagy.

PubMed ID: 23994764

DOI: 10.1016/j.semcancer.2013.08.002

PubMed ID: 24971542

Title: HMGB1-DNA complex-induced autophagy limits AIM2 inflammasome activation through RAGE.

PubMed ID: 24971542

DOI: 10.1016/j.bbrc.2014.06.074

PubMed ID: 24474694

Title: An immunogenic peptide in the A-box of HMGB1 protein reverses apoptosis-induced tolerance through RAGE receptor.

PubMed ID: 24474694

DOI: 10.1074/jbc.m113.541474

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24531895

Title: A systematic nomenclature for the redox states of high mobility group box (HMGB) proteins.

PubMed ID: 24531895

DOI: 10.2119/molmed.2014.00022

PubMed ID: 24220159

Title: An overview on HMGB1 inhibitors as potential therapeutic agents in HMGB1-related pathologies.

PubMed ID: 24220159

DOI: 10.1016/j.pharmthera.2013.11.001

PubMed ID: 25549101

Title: Role of high mobility group box 1 (HMGB1) in SCA17 pathogenesis.

PubMed ID: 25549101

DOI: 10.1371/journal.pone.0115809

PubMed ID: 25048472

Title: The role of high mobility group box 1 in innate immunity.

PubMed ID: 25048472

DOI: 10.3349/ymj.2014.55.5.1165

PubMed ID: 26078984

Title: HMGB1 promotes systemic lupus erythematosus by enhancing macrophage inflammatory response.

PubMed ID: 26078984

DOI: 10.1155/2015/946748

PubMed ID: 25660311

Title: HMGB1 binds to lipoteichoic acid and enhances TNF-alpha and IL-6 production through HMGB1-mediated transfer of lipoteichoic acid to CD14 and TLR2.

PubMed ID: 25660311

DOI: 10.1159/000369972

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27362237

Title: A core viral protein binds host nucleosomes to sequester immune danger signals.

PubMed ID: 27362237

DOI: 10.1038/nature18317

PubMed ID: 28190768

Title: Serine ADP-ribosylation depends on HPF1.

PubMed ID: 28190768

DOI: 10.1016/j.molcel.2017.01.003

PubMed ID: 29618516

Title: The proinflammatory protein HMGB1 is a substrate of transglutaminase-2 and forms high-molecular weight complexes with autoantigens.

PubMed ID: 29618516

DOI: 10.1074/jbc.ra117.001078

PubMed ID: 33147444

Title: Genome-wide CRISPR Screens Reveal Host Factors Critical for SARS-CoV-2 Infection.

PubMed ID: 33147444

DOI: 10.1016/j.cell.2020.10.028

PubMed ID: 34743181

Title: LPS-induced macrophage HMGB1-loaded extracellular vesicles trigger hepatocyte pyroptosis by activating the NLRP3 inflammasome.

PubMed ID: 34743181

DOI: 10.1038/s41420-021-00729-0

PubMed ID: 34922257

Title: The danger molecule HMGB1 cooperates with the NLRP3 inflammasome to sustain expression of the EBV lytic switch protein in Burkitt lymphoma cells.

PubMed ID: 34922257

DOI: 10.1016/j.virol.2021.12.002

PubMed ID: 36585612

Title: USP13 regulates HMGB1 stability and secretion through its deubiquitinase activity.

PubMed ID: 36585612

DOI: 10.1186/s10020-022-00596-0

PubMed ID: 34971702

Title: High-mobility group box 1 protein promotes dengue virus replication by interacting with untranslated regions of viral genome.

PubMed ID: 34971702

DOI: 10.1016/j.virusres.2021.198668

PubMed ID: 35239449

Title: SARS-CoV-2 ORF3a induces RETREG1/FAM134B-dependent reticulophagy and triggers sequential ER stress and inflammatory responses during SARS-CoV-2 infection.

PubMed ID: 35239449

DOI: 10.1080/15548627.2022.2039992

PubMed ID: 23063560

Title: HMGB1-facilitated p53 DNA binding occurs via HMG-Box/p53 transactivation domain interaction, regulated by the acidic tail.

PubMed ID: 23063560

DOI: 10.1016/j.str.2012.09.004

PubMed ID: 24427810

Title: Redox-sensitive structural change in the A-domain of HMGB1 and its implication for the binding to cisplatin modified DNA.

PubMed ID: 24427810

DOI: 10.1016/j.bbrc.2013.10.085

Sequence Information:

  • Length: 215
  • Mass: 24894
  • Checksum: 8A868CF277D417B5
  • Sequence:
    • MGKGDPKKPR GKMSSYAFFV QTCREEHKKK HPDASVNFSE FSKKCSERWK TMSAKEKGKF 
EDMAKADKAR YEREMKTYIP PKGETKKKFK DPNAPKRPPS AFFLFCSEYR PKIKGEHPGL 
SIGDVAKKLG EMWNNTAADD KQPYEKKAAK LKEKYEKDIA AYRAKGKPDA AKKGVVKAEK 
SKKKKEEEED EEDEEDEEEE EDEEDEDEEE DDDDE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.