Details for: ELF3

Gene ID: 1999

Symbol: ELF3

Ensembl ID: ENSG00000163435

Description: E74 like ETS transcription factor 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 253.4311
    Cell Significance Index: -39.4200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 155.8487
    Cell Significance Index: -39.5300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 74.3125
    Cell Significance Index: -30.1900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 56.3618
    Cell Significance Index: -37.8200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 31.9719
    Cell Significance Index: -39.4200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 30.7936
    Cell Significance Index: -29.4000
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 26.8020
    Cell Significance Index: 203.2400
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 16.4319
    Cell Significance Index: 101.1300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 15.3759
    Cell Significance Index: -41.1900
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 12.9959
    Cell Significance Index: 80.1800
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 10.9142
    Cell Significance Index: 7.8000
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 10.1097
    Cell Significance Index: 38.7100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 8.7794
    Cell Significance Index: 397.9400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 8.0837
    Cell Significance Index: 74.4400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 7.8746
    Cell Significance Index: 214.3400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 7.7937
    Cell Significance Index: 404.8600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 5.7093
    Cell Significance Index: 425.5100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 4.9939
    Cell Significance Index: 900.2400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 4.5882
    Cell Significance Index: 132.2000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 4.5095
    Cell Significance Index: 104.1900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 4.3026
    Cell Significance Index: 64.4700
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 4.0054
    Cell Significance Index: 46.5600
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 3.8879
    Cell Significance Index: 29.6000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 3.6201
    Cell Significance Index: 445.1300
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 3.5201
    Cell Significance Index: 21.7900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 3.4305
    Cell Significance Index: 443.2000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.3160
    Cell Significance Index: 1810.9700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 3.2464
    Cell Significance Index: 25.9200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 3.1028
    Cell Significance Index: 306.9400
  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: 3.0506
    Cell Significance Index: 16.9800
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 2.5391
    Cell Significance Index: 15.2200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.4328
    Cell Significance Index: 114.3400
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 2.3920
    Cell Significance Index: 24.1300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.0052
    Cell Significance Index: 93.4900
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.9424
    Cell Significance Index: 27.6500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.7453
    Cell Significance Index: 189.8400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.6926
    Cell Significance Index: 117.0500
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 1.4895
    Cell Significance Index: 5.6100
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 1.3489
    Cell Significance Index: 11.1500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.2552
    Cell Significance Index: 19.4200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.0502
    Cell Significance Index: 33.6400
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.0421
    Cell Significance Index: 10.7500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.9569
    Cell Significance Index: 33.6300
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.7940
    Cell Significance Index: 1.7900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6421
    Cell Significance Index: 38.5500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6392
    Cell Significance Index: 282.6100
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: 0.6355
    Cell Significance Index: 6.3600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.6231
    Cell Significance Index: 13.2700
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.5988
    Cell Significance Index: 6.4900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5838
    Cell Significance Index: 115.8500
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 0.5073
    Cell Significance Index: 10.5800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3739
    Cell Significance Index: 71.1500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3625
    Cell Significance Index: 10.1300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.2861
    Cell Significance Index: 32.6600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.2408
    Cell Significance Index: 182.2700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2210
    Cell Significance Index: 37.7400
  • Cell Name: airway submucosal gland collecting duct epithelial cell (CL4033023)
    Fold Change: 0.1168
    Cell Significance Index: 0.8200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0754
    Cell Significance Index: 139.0600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0469
    Cell Significance Index: 0.6400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0347
    Cell Significance Index: 5.6400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0277
    Cell Significance Index: 20.3200
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.0264
    Cell Significance Index: 0.2100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0045
    Cell Significance Index: 0.1200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0023
    Cell Significance Index: 3.4700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0033
    Cell Significance Index: -2.4500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0042
    Cell Significance Index: -0.1700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0069
    Cell Significance Index: -0.3500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0128
    Cell Significance Index: -8.0100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0140
    Cell Significance Index: -0.1500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0171
    Cell Significance Index: -32.2000
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0250
    Cell Significance Index: -0.2300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0305
    Cell Significance Index: -17.2100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0310
    Cell Significance Index: -42.0900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0320
    Cell Significance Index: -3.2700
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.0389
    Cell Significance Index: -0.2700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0412
    Cell Significance Index: -1.0600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0417
    Cell Significance Index: -26.5100
  • Cell Name: eosinophil (CL0000771)
    Fold Change: -0.0460
    Cell Significance Index: -0.4100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0540
    Cell Significance Index: -1.1700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0609
    Cell Significance Index: -12.8300
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0629
    Cell Significance Index: -0.3900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0678
    Cell Significance Index: -1.7000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0688
    Cell Significance Index: -7.8800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0694
    Cell Significance Index: -8.9000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0778
    Cell Significance Index: -10.6800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0826
    Cell Significance Index: -4.3000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0873
    Cell Significance Index: -39.6300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0998
    Cell Significance Index: -35.7900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1269
    Cell Significance Index: -9.7400
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.1398
    Cell Significance Index: -1.8000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1402
    Cell Significance Index: -0.9500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1468
    Cell Significance Index: -42.2400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1499
    Cell Significance Index: -10.6100
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1621
    Cell Significance Index: -1.7100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1629
    Cell Significance Index: -18.9900
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.1660
    Cell Significance Index: -1.8200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1839
    Cell Significance Index: -36.8900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1998
    Cell Significance Index: -2.2700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2279
    Cell Significance Index: -33.1300
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: -0.2396
    Cell Significance Index: -0.3100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ELF3 is a transcription factor that belongs to the ETS family, which is characterized by the presence of a conserved ETS domain. This domain is responsible for DNA binding and transcriptional activation. ELF3 is specifically expressed in various cell types, including secretory cells, epithelial cells of the prostate, colon, and lung, as well as taste receptor cells and goblet cells in the nasal mucosa and intestine. Its expression is often regulated by Notch signaling, a key pathway involved in cell fate determination and differentiation. **Pathways and Functions:** ELF3 is involved in various biological pathways, including: 1. **Blastocyst development:** ELF3 plays a crucial role in the development of the blastocyst, a stage of embryonic development characterized by rapid cell growth and differentiation. 2. **Cell differentiation:** ELF3 regulates the expression of genes involved in cell differentiation, including those involved in the development of epithelial cells, secretory cells, and goblet cells. 3. **Chromatin organization:** ELF3 interacts with chromatin-modifying enzymes to regulate chromatin structure and gene expression. 4. **Inflammatory response:** ELF3 is involved in the regulation of the inflammatory response, which is critical for maintaining tissue homeostasis and preventing disease. 5. **Mammary gland involution:** ELF3 plays a role in the regulation of mammary gland involution, a process critical for maintaining tissue homeostasis after pregnancy. **Clinical Significance:** ELF3 has been implicated in various diseases, including: 1. **Cancer:** ELF3 is overexpressed in several types of cancer, including prostate, colon, and lung cancer, suggesting its potential as a diagnostic biomarker or therapeutic target. 2. **Inflammatory bowel disease:** ELF3 is involved in the regulation of the inflammatory response in inflammatory bowel disease, a chronic condition characterized by inflammation of the gastrointestinal tract. 3. **Asthma:** ELF3 is expressed in airway epithelial cells and plays a role in the regulation of airway inflammation, a key feature of asthma. 4. **Neurological disorders:** ELF3 has been implicated in the regulation of neuroinflammation and neuronal survival, suggesting its potential as a therapeutic target in neurological disorders such as Alzheimer's disease and Parkinson's disease. In conclusion, ELF3 is a multifunctional transcription factor that plays critical roles in various biological pathways, including cell differentiation, inflammation, and chromatin organization. Its involvement in multiple diseases highlights its potential as a therapeutic target and diagnostic biomarker. Further research is needed to fully elucidate the mechanisms by which ELF3 regulates gene expression and to explore its therapeutic potential in various diseases.

Genular Protein ID: 2863373268

Symbol: ELF3_HUMAN

Name: ETS-related transcription factor Elf-3

UniProtKB Accession Codes:

P78545 B2R5Q6 Q6IAP8 Q7RU03 Q7Z3X2 Q8NFG2 Q99718

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 15 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 18 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9234700

Title: Isolation and characterization of a novel epithelium-specific transcription factor, ESE-1, a member of the ets family.

PubMed ID: 9234700

DOI: 10.1128/mcb.17.8.4419

PubMed ID: 9336459

Title: The expression of a novel, epithelium-specific ets transcription factor is restricted to the most differentiated layers in the epidermis.

PubMed ID: 9336459

DOI: 10.1093/nar/25.21.4287

PubMed ID: 9129154

Title: ESX: a structurally unique Ets overexpressed early during human breast tumorigenesis.

PubMed ID: 9129154

DOI: 10.1038/sj.onc.1200978

PubMed ID: 9395241

Title: A novel epithelial-expressed ETS gene, ELF3: human and murine cDNA sequences, murine genomic organization, human mapping to 1q32.2 and expression in tissues and cancer.

PubMed ID: 9395241

DOI: 10.1038/sj.onc.1201427

PubMed ID: 9417054

Title: A novel ets-related transcription factor, ERT/ESX/ESE-1, regulates expression of the transforming growth factor-beta type II receptor.

PubMed ID: 9417054

DOI: 10.1074/jbc.273.1.110

PubMed ID: 10391676

Title: Exon 4-encoded acidic domain in the epithelium-restricted Ets factor, ESX, confers potent transactivating capacity and binds to TATA-binding protein (TBP).

PubMed ID: 10391676

DOI: 10.1038/sj.onc.1202674

PubMed ID: 12119107

Title: Human aminopeptidase B (rnpep) on chromosome 1q32.2: complementary DNA, genomic structure and expression.

PubMed ID: 12119107

DOI: 10.1016/s0378-1119(02)00650-9

PubMed ID: 14997048

Title: Partially unspliced and fully spliced ELF3 mRNA, including a new Alu element in human breast cancer.

PubMed ID: 14997048

DOI: 10.1023/b:brea.0000010710.51614.2d

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10644990

Title: Over-expression of ERT(ESX/ESE-1/ELF3), an ets-related transcription factor, induces endogenous TGF-beta type II receptor expression and restores the TGF-beta signaling pathway in Hs578t human breast cancer cells.

PubMed ID: 10644990

DOI: 10.1038/sj.onc.1203252

PubMed ID: 10773884

Title: Dual function of the epithelial specific ets transcription factor, ELF3, in modulating differentiation.

PubMed ID: 10773884

DOI: 10.1038/sj.onc.1203441

PubMed ID: 11036073

Title: ESE-1 is a novel transcriptional mediator of inflammation that interacts with NF-kappa B to regulate the inducible nitric-oxide synthase gene.

PubMed ID: 11036073

DOI: 10.1074/jbc.m006507200

PubMed ID: 11313868

Title: Sequence-specific enhancer binding protein is responsible for the differential expression of ERT/ESX/ELF-3/ESE-1/jen gene in human gastric cancer cell lines: implication for the loss of TGF-beta type II receptor expression.

PubMed ID: 11313868

DOI: 10.1038/sj.onc.1204227

PubMed ID: 12032832

Title: ErbB2 activation of ESX gene expression.

PubMed ID: 12032832

DOI: 10.1038/sj.onc.1205503

PubMed ID: 12713734

Title: The epithelial-specific ETS transcription factor ESX/ESE-1/Elf-3 modulates breast cancer-associated gene expression.

PubMed ID: 12713734

DOI: 10.1089/104454903321515896

PubMed ID: 12414801

Title: ESE-1, an enterocyte-specific Ets transcription factor, regulates MIP-3alpha gene expression in Caco-2 human colonic epithelial cells.

PubMed ID: 12414801

DOI: 10.1074/jbc.m208241200

PubMed ID: 12624109

Title: Distinct functional interactions of human Skn-1 isoforms with Ese-1 during keratinocyte terminal differentiation.

PubMed ID: 12624109

DOI: 10.1074/jbc.m300508200

PubMed ID: 12682075

Title: Interplay between proximal and distal promoter elements is required for squamous differentiation marker induction in the bronchial epithelium: role for ESE-1, Sp1, and AP-1 proteins.

PubMed ID: 12682075

DOI: 10.1074/jbc.m212258200

PubMed ID: 14715662

Title: ESE-1 is a novel transcriptional mediator of angiopoietin-1 expression in the setting of inflammation.

PubMed ID: 14715662

DOI: 10.1074/jbc.m308593200

PubMed ID: 15075319

Title: Positive and negative modulation of the transcriptional activity of the ETS factor ESE-1 through interaction with p300, CREB-binding protein, and Ku 70/86.

PubMed ID: 15075319

DOI: 10.1074/jbc.m401356200

PubMed ID: 15169914

Title: The ETS transcription factor ESE-1 transforms MCF-12A human mammary epithelial cells via a novel cytoplasmic mechanism.

PubMed ID: 15169914

DOI: 10.1128/mcb.24.12.5548-5564.2004

PubMed ID: 14767472

Title: ESX induces transformation and functional epithelial to mesenchymal transition in MCF-12A mammary epithelial cells.

PubMed ID: 14767472

DOI: 10.1038/sj.onc.1207391

PubMed ID: 15794755

Title: The Ets transcription factor ESE-1 mediates induction of the COX-2 gene by LPS in monocytes.

PubMed ID: 15794755

DOI: 10.1111/j.1742-4658.2005.04592.x

PubMed ID: 16307850

Title: Identification of an epithelial-specific enhancer regulating ESX expression.

PubMed ID: 16307850

DOI: 10.1016/j.gene.2005.10.001

PubMed ID: 17060315

Title: Expression of claudin7 is tightly associated with epithelial structures in synovial sarcomas and regulated by an Ets family transcription factor, ELF3.

PubMed ID: 17060315

DOI: 10.1074/jbc.m608389200

PubMed ID: 17467953

Title: Nine-amino-acid transactivation domain: establishment and prediction utilities.

PubMed ID: 17467953

DOI: 10.1016/j.ygeno.2007.02.003

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 30476274

Title: MIR sequences recruit zinc finger protein ZNF768 to expressed genes.

PubMed ID: 30476274

DOI: 10.1093/nar/gky1148

Sequence Information:

  • Length: 371
  • Mass: 41454
  • Checksum: 81A23A7DECBE2EF9
  • Sequence:
    • MAATCEISNI FSNYFSAMYS SEDSTLASVP PAATFGADDL VLTLSNPQMS LEGTEKASWL 
GEQPQFWSKT QVLDWISYQV EKNKYDASAI DFSRCDMDGA TLCNCALEEL RLVFGPLGDQ 
LHAQLRDLTS SSSDELSWII ELLEKDGMAF QEALDPGPFD QGSPFAQELL DDGQQASPYH 
PGSCGAGAPS PGSSDVSTAG TGASRSSHSS DSGGSDVDLD PTDGKLFPSD GFRDCKKGDP 
KHGKRKRGRP RKLSKEYWDC LEGKKSKHAP RGTHLWEFIR DILIHPELNE GLMKWENRHE 
GVFKFLRSEA VAQLWGQKKK NSNMTYEKLS RAMRYYYKRE ILERVDGRRL VYKFGKNSSG 
WKEEEVLQSR N

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.