Details for: CL0000151

Cell ID: CL0000151

Cell Name: secretory cell

Marker Score Threshold: 1825
(Derived using integrated single-cell and genomic data)

Description: A cell that specializes in controlled release of one or more substances.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 6.26
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 4.49
    Ensembl ID: ENSG00000075624
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 4.45
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 3.84
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 3.63
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 3.45
    Ensembl ID: ENSG00000135046
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 3.4
    Ensembl ID: ENSG00000134825
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 3.31
    Ensembl ID: ENSG00000198668
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 3.21
    Ensembl ID: ENSG00000100300
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 3.04
    Ensembl ID: ENSG00000143153
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 3.03
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ALDH1A1 (ENSG00000165092)
    Fold Change: 3.02
    Ensembl ID: ENSG00000165092
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 3
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ALCAM (ENSG00000170017)
    Fold Change: 2.78
    Ensembl ID: ENSG00000170017
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 2.78
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 2.73
    Ensembl ID: ENSG00000163399
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.68
    Ensembl ID: ENSG00000133639
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.64
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 2.6
    Ensembl ID: ENSG00000122359
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 2.57
    Ensembl ID: ENSG00000142192
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 2.48
    Ensembl ID: ENSG00000107262
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 2.47
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ALDH2 (ENSG00000111275)
    Fold Change: 2.41
    Ensembl ID: ENSG00000111275
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 2.36
    Ensembl ID: ENSG00000177556
  • Gene Symbol: KLF5 (ENSG00000102554)
    Fold Change: 2.33
    Ensembl ID: ENSG00000102554
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 2.33
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 2.3
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 2.26
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.09
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 2.07
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 2
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.95
    Ensembl ID: ENSG00000164111
  • Gene Symbol: BLVRB (ENSG00000090013)
    Fold Change: 1.94
    Ensembl ID: ENSG00000090013
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.93
    Ensembl ID: ENSG00000155366
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.92
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.91
    Ensembl ID: ENSG00000130402
  • Gene Symbol: CCND1 (ENSG00000110092)
    Fold Change: 1.89
    Ensembl ID: ENSG00000110092
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 1.85
    Ensembl ID: ENSG00000198363
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.85
    Ensembl ID: ENSG00000069849
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.81
    Ensembl ID: ENSG00000183255
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.75
    Ensembl ID: ENSG00000179218
  • Gene Symbol: RND3 (ENSG00000115963)
    Fold Change: 1.74
    Ensembl ID: ENSG00000115963
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.69
    Ensembl ID: ENSG00000130303
  • Gene Symbol: ASS1 (ENSG00000130707)
    Fold Change: 1.69
    Ensembl ID: ENSG00000130707
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.58
    Ensembl ID: ENSG00000004455
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.55
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.55
    Ensembl ID: ENSG00000143727
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.54
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 1.52
    Ensembl ID: ENSG00000156110
  • Gene Symbol: ARL1 (ENSG00000120805)
    Fold Change: 1.5
    Ensembl ID: ENSG00000120805
  • Gene Symbol: ANK3 (ENSG00000151150)
    Fold Change: 1.5
    Ensembl ID: ENSG00000151150
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.49
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.49
    Ensembl ID: ENSG00000148700
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 1.49
    Ensembl ID: ENSG00000196975
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.48
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.47
    Ensembl ID: ENSG00000004059
  • Gene Symbol: AQP3 (ENSG00000165272)
    Fold Change: 1.46
    Ensembl ID: ENSG00000165272
  • Gene Symbol: BIRC3 (ENSG00000023445)
    Fold Change: 1.45
    Ensembl ID: ENSG00000023445
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 1.39
    Ensembl ID: ENSG00000184009
  • Gene Symbol: BIK (ENSG00000100290)
    Fold Change: 1.38
    Ensembl ID: ENSG00000100290
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.35
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.35
    Ensembl ID: ENSG00000174437
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 1.33
    Ensembl ID: ENSG00000169100
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 1.32
    Ensembl ID: ENSG00000143933
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 1.31
    Ensembl ID: ENSG00000100852
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.3
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ANXA3 (ENSG00000138772)
    Fold Change: 1.3
    Ensembl ID: ENSG00000138772
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.28
    Ensembl ID: ENSG00000111348
  • Gene Symbol: BID (ENSG00000015475)
    Fold Change: 1.28
    Ensembl ID: ENSG00000015475
  • Gene Symbol: AQP5 (ENSG00000161798)
    Fold Change: 1.28
    Ensembl ID: ENSG00000161798
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.27
    Ensembl ID: ENSG00000087088
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.26
    Ensembl ID: ENSG00000100823
  • Gene Symbol: AHR (ENSG00000106546)
    Fold Change: 1.22
    Ensembl ID: ENSG00000106546
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.21
    Ensembl ID: ENSG00000137845
  • Gene Symbol: BCL6 (ENSG00000113916)
    Fold Change: 1.19
    Ensembl ID: ENSG00000113916
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.19
    Ensembl ID: ENSG00000197894
  • Gene Symbol: ZFHX3 (ENSG00000140836)
    Fold Change: 1.16
    Ensembl ID: ENSG00000140836
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.15
    Ensembl ID: ENSG00000123505
  • Gene Symbol: BMPR1B (ENSG00000138696)
    Fold Change: 1.15
    Ensembl ID: ENSG00000138696
  • Gene Symbol: BMPR2 (ENSG00000204217)
    Fold Change: 1.15
    Ensembl ID: ENSG00000204217
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.15
    Ensembl ID: ENSG00000160710
  • Gene Symbol: BAD (ENSG00000002330)
    Fold Change: 1.14
    Ensembl ID: ENSG00000002330
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 1.14
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 1.13
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ADH7 (ENSG00000196344)
    Fold Change: 1.13
    Ensembl ID: ENSG00000196344
  • Gene Symbol: ACAT2 (ENSG00000120437)
    Fold Change: 1.12
    Ensembl ID: ENSG00000120437
  • Gene Symbol: XIAP (ENSG00000101966)
    Fold Change: 1.12
    Ensembl ID: ENSG00000101966
  • Gene Symbol: BCL2L1 (ENSG00000171552)
    Fold Change: 1.11
    Ensembl ID: ENSG00000171552
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.09
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ALDH3A2 (ENSG00000072210)
    Fold Change: 1.08
    Ensembl ID: ENSG00000072210
  • Gene Symbol: AAMP (ENSG00000127837)
    Fold Change: 1.08
    Ensembl ID: ENSG00000127837
  • Gene Symbol: ATP12A (ENSG00000075673)
    Fold Change: 1.07
    Ensembl ID: ENSG00000075673
  • Gene Symbol: CALU (ENSG00000128595)
    Fold Change: 1.07
    Ensembl ID: ENSG00000128595
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.07
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ACO2 (ENSG00000100412)
    Fold Change: 1.05
    Ensembl ID: ENSG00000100412
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.05
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.03
    Ensembl ID: ENSG00000131100
  • Gene Symbol: ATF3 (ENSG00000162772)
    Fold Change: 1.02
    Ensembl ID: ENSG00000162772
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.01
    Ensembl ID: ENSG00000087274
  • Gene Symbol: ACYP2 (ENSG00000170634)
    Fold Change: 1.01
    Ensembl ID: ENSG00000170634
Hovered Details

Hover over a box to see details here...

Hovered Details

Hover over a box to see details here...

**Key Characteristics** The secretory cell has several key characteristics that enable it to perform its functions: 1. **Controlled release of substances**: The cell specializes in the controlled release of one or more substances, which is essential for its functions. 2. **Antigen presentation**: The cell is involved in antigen presentation, which is a critical step in the immune response. 3. **Immune response**: The cell plays a role in the immune response, including the activation of immune cells and the production of cytokines. 4. **Cellular signaling**: The cell is involved in various signaling pathways, including Dap12 signaling, interferon signaling, and others. 5. **Interaction with other cells and molecules**: The cell interacts with other cells and molecules, including antigen-presenting cells, immune cells, and signaling molecules. **Clinical Significance** The secretory cell has significant clinical implications: 1. **Immune disorders**: Dysregulation of the secretory cell's functions can lead to immune disorders, such as autoimmune diseases and immunodeficiency diseases. 2. **Cancer**: The cell's ability to control the release of substances can be exploited by cancer cells to evade the immune response and promote tumor growth. 3. **Infectious diseases**: The cell's role in antigen presentation and immune response can be critical in the development of infectious diseases, such as HIV and tuberculosis. 4. **Neurological disorders**: The cell's interaction with other cells and molecules can be involved in the development of neurological disorders, such as Alzheimer's disease and Parkinson's disease. **Diseases Associated with This Cell** Several diseases have been associated with alterations in the secretory cell's functions: 1. **Autoimmune diseases**: Conditions such as rheumatoid arthritis, lupus, and multiple sclerosis have been linked to dysregulation of the secretory cell's functions. 2. **Cancer**: Tumors that exploit the cell's ability to control the release of substances can lead to cancer progression. 3. **Infectious diseases**: HIV and tuberculosis have been linked to dysregulation of the secretory cell's functions. 4. **Neurological disorders**: Alzheimer's disease and Parkinson's disease have been associated with alterations in the cell's interaction with other cells and molecules. **Therapeutic Targeting** The secretory cell's functions can be targeted therapeutically to treat various diseases: 1. **Antigen presentation**: Modulating the cell's antigen presentation functions can be used to treat autoimmune diseases and cancer. 2. **Immune response**: Targeting the cell's immune response functions can be used to treat infectious diseases and cancer. 3. **Cellular signaling**: Modulating the cell's signaling pathways can be used to treat neurological disorders and cancer. In conclusion, the secretory cell is a specialized cell type that plays a critical role in various biological processes, including antigen presentation, immune response, and cellular signaling. Its dysregulation can lead to various diseases, and targeting its functions can be a promising therapeutic approach.