Details for: KRT4

Gene ID: 3851

Symbol: KRT4

Ensembl ID: ENSG00000170477

Description: keratin 4

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 4.15
    Marker Score: 3464
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 3.11
    Marker Score: 26836
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 3.04
    Marker Score: 23722
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 2.57
    Marker Score: 620
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.9
    Marker Score: 2001
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.78
    Marker Score: 1212
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.74
    Marker Score: 1164
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.59
    Marker Score: 1158
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.18
    Marker Score: 1336
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.17
    Marker Score: 484
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4788
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.09
    Marker Score: 500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.02
    Marker Score: 690
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 506
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 459
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2410
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.93
    Marker Score: 1085
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 371
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 323
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5294
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.86
    Marker Score: 950
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.84
    Marker Score: 1528
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.78
    Marker Score: 5843
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1256
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.77
    Marker Score: 996
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 702
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.76
    Marker Score: 1042
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.73
    Marker Score: 212
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 459
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.58
    Marker Score: 462
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 172
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.54
    Marker Score: 253.5
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.52
    Marker Score: 293
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.5
    Marker Score: 809
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.48
    Marker Score: 221
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.47
    Marker Score: 571
  • Cell Name: phagocyte (CL0000234)
    Fold Change: 0.44
    Marker Score: 145
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.39
    Marker Score: 308
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.38
    Marker Score: 160
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.37
    Marker Score: 1048
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.37
    Marker Score: 135
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.36
    Marker Score: 1222
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.35
    Marker Score: 112
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.33
    Marker Score: 190
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.33
    Marker Score: 201
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.31
    Marker Score: 162
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.29
    Marker Score: 2492
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.29
    Marker Score: 544
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.25
    Marker Score: 226
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.25
    Marker Score: 60
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.25
    Marker Score: 277
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.25
    Marker Score: 63
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.24
    Marker Score: 97
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.24
    Marker Score: 1134
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.23
    Marker Score: 333
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.23
    Marker Score: 60
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.22
    Marker Score: 58
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.22
    Marker Score: 55
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.21
    Marker Score: 123
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.21
    Marker Score: 55
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.21
    Marker Score: 138
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.21
    Marker Score: 184
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.2
    Marker Score: 54
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.2
    Marker Score: 133
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.2
    Marker Score: 328
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.2
    Marker Score: 193
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 0.2
    Marker Score: 53
  • Cell Name: parietal cell (CL0000162)
    Fold Change: 0.2
    Marker Score: 55
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 0.19
    Marker Score: 52
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.19
    Marker Score: 54.5
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.18
    Marker Score: 91
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.18
    Marker Score: 52
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.18
    Marker Score: 59
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.18
    Marker Score: 344
  • Cell Name: brush cell of trachebronchial tree (CL0002075)
    Fold Change: 0.18
    Marker Score: 56
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.18
    Marker Score: 1200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.18
    Marker Score: 43
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.18
    Marker Score: 44
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.17
    Marker Score: 83
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.17
    Marker Score: 166
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.17
    Marker Score: 50
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.17
    Marker Score: 55
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.17
    Marker Score: 1088
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.17
    Marker Score: 88
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.16
    Marker Score: 144
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.16
    Marker Score: 58
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 0.16
    Marker Score: 52
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.16
    Marker Score: 116
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: 0.16
    Marker Score: 45
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.16
    Marker Score: 59
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.16
    Marker Score: 2111
  • Cell Name: surface ectodermal cell (CL0000114)
    Fold Change: 0.16
    Marker Score: 56
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: 0.16
    Marker Score: 57
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.16
    Marker Score: 86
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.15
    Marker Score: 47

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Other Information

**Key characteristics:** * The KRT4 gene is located on chromosome 17q21.1. * It is a large gene with a transcript length of approximately 32,000 nucleotides. * The protein encoded by KRT4 is a transmembrane protein with a molecular weight of approximately 120 kDa. * Keratin 4 is a member of the keratin family of cytoskeletal proteins, which are responsible for the assembly and maintenance of cell surfaces and the cytoskeleton. **Pathways and functions:** * Keratin 4 is involved in the formation of the cornified envelope. The cornified envelope is a complex network of cell surface structures that protects the body from the external environment. Keratin 4 is a major component of the cornified envelope, and its absence leads to the development of a weakened and fragile skin. * Keratin 4 is also involved in the organization of the cytoskeleton. The cytoskeleton is a network of protein filaments that provides structural support and helps to maintain the integrity of cell membranes. Keratin 4 is a key component of the cytoskeleton, and its absence leads to the development of a variety of cellular abnormalities, including cell cycle defects and cancer. * In addition to its roles in the formation of the cornified envelope and the cytoskeleton, keratin 4 is also involved in a variety of other cellular processes, including cell migration, cell adhesion, and cell differentiation. **Clinical significance:** Mutations in the KRT4 gene have been linked to a number of human diseases, including skin disorders such as epidermolysis bullosa simplex, psoriasis, and ichthyosis vulgaris. In addition, mutations in KRT4 have been linked to an increased risk of cancer, particularly skin cancer.

Genular Protein ID: 3072792089

Symbol: K2C4_HUMAN

Name: Keratin, type II cytoskeletal 4

UniProtKB Accession Codes:

P19013 B4DRS2 F8VS64 Q6GTR8 Q96LA7 Q9BTL1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 1 ExpressionAtlas 1 GO 12 Gene3D 3 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7684424

Title: Allelic variations of human keratins K4 and K5 provide polymorphic markers within the type II keratin gene cluster on chromosome 12.

PubMed ID: 7684424

DOI: 10.1111/1523-1747.ep12475671

PubMed ID: 2452170

Title: Molecular characterization and expression of the stratification-related cytokeratins 4 and 15.

PubMed ID: 2452170

DOI: 10.1083/jcb.106.4.1249

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 10652003

Title: A glutamine insertion in the 1A alpha helical domain of the keratin 4 gene in a familial case of white sponge nevus.

PubMed ID: 10652003

DOI: 10.1046/j.1523-1747.2000.00890.x

PubMed ID: 12828738

Title: A novel mutation in the keratin 4 gene causing white sponge naevus.

PubMed ID: 12828738

DOI: 10.1046/j.1365-2133.2003.05337.x

Sequence Information:

  • Length: 520
  • Mass: 56144
  • Checksum: 3997CA71E7586F4C
  • Sequence:
    • MIARQQCVRG GPRGFSCGSA IVGGGKRGAF SSVSMSGGAG RCSSGGFGSR SLYNLRGNKS 
ISMSVAGSRQ GACFGGAGGF GTGGFGGGFG GSFSGKGGPG FPVCPAGGIQ EVTINQSLLT 
PLHVEIDPEI QKVRTEEREQ IKLLNNKFAS FIDKVQFLEQ QNKVLETKWN LLQQQTTTTS 
SKNLEPLFET YLSVLRKQLD TLGNDKGRLQ SELKTMQDSV EDFKTKYEEE INKRTAAEND 
FVVLKKDVDA AYLNKVELEA KVDSLNDEIN FLKVLYDAEL SQMQTHVSDT SVVLSMDNNR 
NLDLDSIIAE VRAQYEEIAQ RSKAEAEALY QTKVQQLQIS VDQHGDNLKN TKSEIAELNR 
MIQRLRAEIE NIKKQCQTLQ VSVADAEQRG ENALKDAHSK RVELEAALQQ AKEELARMLR 
EYQELMSVKL ALDIEIATYR KLLEGEEYRM SGECQSAVSI SVVSGSTSTG GISGGLGSGS 
GFGLSSGFGS GSGSGFGFGG SVSGSSSSKI ISTTTLNKRR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.