Details for: CL0000576

Cell ID: CL0000576

Cell Name: monocyte

Marker Score Threshold: 1300
(Derived using integrated single-cell and genomic data)

Description: Myeloid mononuclear recirculating leukocyte that can act as a precursor of tissue macrophages, osteoclasts and some populations of tissue dendritic cells.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.17
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.97
    Ensembl ID: ENSG00000166710
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 2.48
    Ensembl ID: ENSG00000172757
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 2.28
    Ensembl ID: ENSG00000019582
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.26
    Ensembl ID: ENSG00000145741
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.19
    Ensembl ID: ENSG00000198668
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.17
    Ensembl ID: ENSG00000067560
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 2.11
    Ensembl ID: ENSG00000135404
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.01
    Ensembl ID: ENSG00000133639
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 2
    Ensembl ID: ENSG00000070831
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.93
    Ensembl ID: ENSG00000077549
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 1.83
    Ensembl ID: ENSG00000099622
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.79
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.75
    Ensembl ID: ENSG00000143761
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.69
    Ensembl ID: ENSG00000100300
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 1.68
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ALPG (ENSG00000163286)
    Fold Change: 1.68
    Ensembl ID: ENSG00000163286
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.67
    Ensembl ID: ENSG00000135046
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.67
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.66
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 1.66
    Ensembl ID: ENSG00000184009
  • Gene Symbol: CD52 (ENSG00000169442)
    Fold Change: 1.65
    Ensembl ID: ENSG00000169442
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.65
    Ensembl ID: ENSG00000084234
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.63
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.62
    Ensembl ID: ENSG00000164111
  • Gene Symbol: NR0B1 (ENSG00000169297)
    Fold Change: 1.61
    Ensembl ID: ENSG00000169297
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.61
    Ensembl ID: ENSG00000104763
  • Gene Symbol: CDH12 (ENSG00000154162)
    Fold Change: 1.61
    Ensembl ID: ENSG00000154162
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 1.6
    Ensembl ID: ENSG00000026508
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.6
    Ensembl ID: ENSG00000185650
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.59
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.57
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 1.56
    Ensembl ID: ENSG00000124172
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.54
    Ensembl ID: ENSG00000153113
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.53
    Ensembl ID: ENSG00000152518
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.52
    Ensembl ID: ENSG00000179218
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.49
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 1.49
    Ensembl ID: ENSG00000135390
  • Gene Symbol: AP2S1 (ENSG00000042753)
    Fold Change: 1.49
    Ensembl ID: ENSG00000042753
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.46
    Ensembl ID: ENSG00000198898
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.45
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.43
    Ensembl ID: ENSG00000069849
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.42
    Ensembl ID: ENSG00000198931
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.41
    Ensembl ID: ENSG00000116489
  • Gene Symbol: CEBPB (ENSG00000172216)
    Fold Change: 1.41
    Ensembl ID: ENSG00000172216
  • Gene Symbol: CD53 (ENSG00000143119)
    Fold Change: 1.36
    Ensembl ID: ENSG00000143119
  • Gene Symbol: CTSC (ENSG00000109861)
    Fold Change: 1.35
    Ensembl ID: ENSG00000109861
  • Gene Symbol: AP2M1 (ENSG00000161203)
    Fold Change: 1.35
    Ensembl ID: ENSG00000161203
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.34
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.33
    Ensembl ID: ENSG00000163399
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 1.33
    Ensembl ID: ENSG00000143933
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.32
    Ensembl ID: ENSG00000160014
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.31
    Ensembl ID: ENSG00000104765
  • Gene Symbol: CEBPD (ENSG00000221869)
    Fold Change: 1.3
    Ensembl ID: ENSG00000221869
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.29
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.29
    Ensembl ID: ENSG00000141522
  • Gene Symbol: AQP2 (ENSG00000167580)
    Fold Change: 1.28
    Ensembl ID: ENSG00000167580
  • Gene Symbol: PLIN2 (ENSG00000147872)
    Fold Change: 1.28
    Ensembl ID: ENSG00000147872
  • Gene Symbol: ALK (ENSG00000171094)
    Fold Change: 1.28
    Ensembl ID: ENSG00000171094
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.28
    Ensembl ID: ENSG00000130303
  • Gene Symbol: CD37 (ENSG00000104894)
    Fold Change: 1.28
    Ensembl ID: ENSG00000104894
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.25
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.24
    Ensembl ID: ENSG00000070961
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.22
    Ensembl ID: ENSG00000087088
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.21
    Ensembl ID: ENSG00000196776
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.2
    Ensembl ID: ENSG00000130402
  • Gene Symbol: BLVRB (ENSG00000090013)
    Fold Change: 1.19
    Ensembl ID: ENSG00000090013
  • Gene Symbol: CLIC1 (ENSG00000213719)
    Fold Change: 1.18
    Ensembl ID: ENSG00000213719
  • Gene Symbol: CCKBR (ENSG00000110148)
    Fold Change: 1.18
    Ensembl ID: ENSG00000110148
  • Gene Symbol: CAPG (ENSG00000042493)
    Fold Change: 1.17
    Ensembl ID: ENSG00000042493
  • Gene Symbol: CHD2 (ENSG00000173575)
    Fold Change: 1.17
    Ensembl ID: ENSG00000173575
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.16
    Ensembl ID: ENSG00000177556
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.16
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.14
    Ensembl ID: ENSG00000154518
  • Gene Symbol: CHD1 (ENSG00000153922)
    Fold Change: 1.12
    Ensembl ID: ENSG00000153922
  • Gene Symbol: CDKN1A (ENSG00000124762)
    Fold Change: 1.12
    Ensembl ID: ENSG00000124762
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.11
    Ensembl ID: ENSG00000177105
  • Gene Symbol: CDH4 (ENSG00000179242)
    Fold Change: 1.11
    Ensembl ID: ENSG00000179242
  • Gene Symbol: CD81 (ENSG00000110651)
    Fold Change: 1.11
    Ensembl ID: ENSG00000110651
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.11
    Ensembl ID: ENSG00000115307
  • Gene Symbol: TBCB (ENSG00000105254)
    Fold Change: 1.1
    Ensembl ID: ENSG00000105254
  • Gene Symbol: CLK1 (ENSG00000013441)
    Fold Change: 1.1
    Ensembl ID: ENSG00000013441
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.1
    Ensembl ID: ENSG00000072778
  • Gene Symbol: CAPN2 (ENSG00000162909)
    Fold Change: 1.09
    Ensembl ID: ENSG00000162909
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.09
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.09
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ALDH2 (ENSG00000111275)
    Fold Change: 1.08
    Ensembl ID: ENSG00000111275
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 1.08
    Ensembl ID: ENSG00000122545
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.06
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.06
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.05
    Ensembl ID: ENSG00000165527
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.05
    Ensembl ID: ENSG00000183255
  • Gene Symbol: CAPNS1 (ENSG00000126247)
    Fold Change: 1.05
    Ensembl ID: ENSG00000126247
  • Gene Symbol: CD48 (ENSG00000117091)
    Fold Change: 1.05
    Ensembl ID: ENSG00000117091
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.04
    Ensembl ID: ENSG00000143878
  • Gene Symbol: CGB3 (ENSG00000104827)
    Fold Change: 1.03
    Ensembl ID: ENSG00000104827
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.02
    Ensembl ID: ENSG00000112576
  • Gene Symbol: ATP6V1B2 (ENSG00000147416)
    Fold Change: 1.01
    Ensembl ID: ENSG00000147416
  • Gene Symbol: ARRB2 (ENSG00000141480)
    Fold Change: 1.01
    Ensembl ID: ENSG00000141480
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: N/A
    Ensembl ID: ENSG00000004059
Hovered Details

Hover over a box to see details here...

Hovered Details

Hover over a box to see details here...

**Key Characteristics** **Monocyte (CL0000576)** * Gene Symbol: ACTB * Ensembl ID: ENSG00000075624 * Description: Myeloid mononuclear recirculating leukocyte that can act as a precursor of tissue macrophages, osteoclasts, and some populations of tissue dendritic cells. * Key characteristics: + Actin cytoskeleton and actin filament organization + Adherens junction and apical junction complex formation + Interaction with cytoplasmic ribonucleoprotein granule + Regulation of cell motility and morphology + Role in immune response, inflammation, and tissue repair **B2M (B2M)** * Gene Symbol: B2M * Ensembl ID: ENSG00000166710 * Description: Beta-2 microglobulin protein associated with MHC class I molecules * Key characteristics: + Association with MHC class I molecules + Role in antigen presentation and immune response + Involvement in adaptive immune system and cellular response to pathogens + Regulation of immune cell function and cytokine signaling + Association with various diseases, including cancer and autoimmune disorders **Clinical Significance** **Monocyte (CL0000576)** * Monocytes play a crucial role in the immune response, particularly in the defense against pathogens and the clearance of dead cells. * Dysregulation of monocyte function has been implicated in various diseases, including atherosclerosis, autoimmune disorders, and cancer. * Monocytes can differentiate into different cell types, including macrophages and dendritic cells, which are involved in immune responses and tissue repair. * Monocyte-derived macrophages have been used as a therapeutic tool to target cancer cells and modulate the immune response. **B2M (B2M)** * B2M is a critical component of MHC class I molecules, which play a central role in antigen presentation and immune response. * Dysregulation of B2M expression has been implicated in various diseases, including cancer and autoimmune disorders. * B2M has been used as a biomarker to diagnose and monitor diseases, including multiple sclerosis and cancer. * B2M has potential therapeutic applications, including the development of cancer vaccines and immunotherapies. In conclusion, monocytes and B2M are two cell types that play critical roles in the immune response and various cellular processes. Understanding the key characteristics and clinical significance of these cell types can provide valuable insights into the development of new therapeutic strategies and the diagnosis and treatment of diseases.