Details for: FGB
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 23.9802
Cell Significance Index: -3.7300 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 18.2945
Cell Significance Index: 308.1700 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 14.7057
Cell Significance Index: -3.7300 - Cell Name: hepatic pit cell (CL2000054)
Fold Change: 6.0249
Cell Significance Index: 16.1400 - Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
Fold Change: 4.5790
Cell Significance Index: 15.9300 - Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 4.4532
Cell Significance Index: 25.6500 - Cell Name: intrahepatic cholangiocyte (CL0002538)
Fold Change: 4.2456
Cell Significance Index: 15.9900 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 4.1255
Cell Significance Index: 818.7100 - Cell Name: abnormal cell (CL0001061)
Fold Change: 3.2115
Cell Significance Index: 328.0600 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 2.5122
Cell Significance Index: 37.0800 - Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 2.4149
Cell Significance Index: 19.0700 - Cell Name: liver dendritic cell (CL2000055)
Fold Change: 2.3806
Cell Significance Index: 6.2800 - Cell Name: cholangiocyte (CL1000488)
Fold Change: 1.7793
Cell Significance Index: 17.5600 - Cell Name: hepatoblast (CL0005026)
Fold Change: 1.1701
Cell Significance Index: 19.6800 - Cell Name: mature B cell (CL0000785)
Fold Change: 0.9556
Cell Significance Index: 6.2200 - Cell Name: lung secretory cell (CL1000272)
Fold Change: 0.9509
Cell Significance Index: 7.2400 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.6179
Cell Significance Index: 385.8900 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 0.4847
Cell Significance Index: 11.7400 - Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 0.3850
Cell Significance Index: 3.6600 - Cell Name: Kupffer cell (CL0000091)
Fold Change: 0.2863
Cell Significance Index: 2.6200 - Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 0.2424
Cell Significance Index: 2.5000 - Cell Name: colonocyte (CL1000347)
Fold Change: 0.1780
Cell Significance Index: 1.1000 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.1060
Cell Significance Index: 2.8400 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.0937
Cell Significance Index: 0.9700 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.0305
Cell Significance Index: 3.5600 - Cell Name: neuron associated cell (CL0000095)
Fold Change: 0.0090
Cell Significance Index: 0.3700 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.0035
Cell Significance Index: 2.6000 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: 0.0032
Cell Significance Index: 0.3700 - Cell Name: hepatocyte (CL0000182)
Fold Change: 0.0000
Cell Significance Index: 0.0000 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0009
Cell Significance Index: -0.5000 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0018
Cell Significance Index: -0.0800 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0021
Cell Significance Index: -3.9500 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0028
Cell Significance Index: -5.2200 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0033
Cell Significance Index: -5.1400 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0039
Cell Significance Index: -5.2900 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0044
Cell Significance Index: -0.9300 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0044
Cell Significance Index: -3.3500 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0055
Cell Significance Index: -0.9400 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0060
Cell Significance Index: -0.6900 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0123
Cell Significance Index: -9.0100 - Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.0145
Cell Significance Index: -0.3600 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0159
Cell Significance Index: -7.2100 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0203
Cell Significance Index: -4.0700 - Cell Name: inflammatory macrophage (CL0000863)
Fold Change: -0.0312
Cell Significance Index: -0.2400 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0321
Cell Significance Index: -4.4100 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0377
Cell Significance Index: -4.8800 - Cell Name: plasmablast (CL0000980)
Fold Change: -0.0431
Cell Significance Index: -0.4000 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0458
Cell Significance Index: -3.4100 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0606
Cell Significance Index: -8.8100 - Cell Name: vascular associated smooth muscle cell (CL0000359)
Fold Change: -0.0631
Cell Significance Index: -0.6700 - Cell Name: proerythroblast (CL0000547)
Fold Change: -0.0727
Cell Significance Index: -1.0400 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.0824
Cell Significance Index: -1.1800 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0855
Cell Significance Index: -5.2400 - Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: -0.0975
Cell Significance Index: -1.2800 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0984
Cell Significance Index: -5.5200 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.1057
Cell Significance Index: -4.9300 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.1059
Cell Significance Index: -5.5000 - Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: -0.1104
Cell Significance Index: -1.8200 - Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: -0.1140
Cell Significance Index: -1.6000 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.1140
Cell Significance Index: -3.6300 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.1176
Cell Significance Index: -4.1200 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1179
Cell Significance Index: -9.3400 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1206
Cell Significance Index: -5.6700 - Cell Name: stem cell (CL0000034)
Fold Change: -0.1211
Cell Significance Index: -0.8800 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.1215
Cell Significance Index: -4.4600 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.1249
Cell Significance Index: -4.0900 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.1289
Cell Significance Index: -3.3900 - Cell Name: erythrocyte (CL0000232)
Fold Change: -0.1319
Cell Significance Index: -3.3600 - Cell Name: keratinocyte (CL0000312)
Fold Change: -0.1469
Cell Significance Index: -3.6700 - Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.1541
Cell Significance Index: -3.7600 - Cell Name: alpha-beta T cell (CL0000789)
Fold Change: -0.1561
Cell Significance Index: -1.3300 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.1586
Cell Significance Index: -4.5500 - Cell Name: neural crest cell (CL0011012)
Fold Change: -0.1594
Cell Significance Index: -1.7300 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: -0.1697
Cell Significance Index: -2.1500 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.1700
Cell Significance Index: -2.5100 - Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: -0.1747
Cell Significance Index: -1.8100 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.1893
Cell Significance Index: -4.0900 - Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
Fold Change: -0.1916
Cell Significance Index: -3.8200 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.1920
Cell Significance Index: -10.0000 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.1927
Cell Significance Index: -4.0900 - Cell Name: transit amplifying cell (CL0009010)
Fold Change: -0.2031
Cell Significance Index: -1.9500 - Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: -0.2099
Cell Significance Index: -2.2800 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.2145
Cell Significance Index: -5.3500 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.2151
Cell Significance Index: -5.7400 - Cell Name: cell of skeletal muscle (CL0000188)
Fold Change: -0.2210
Cell Significance Index: -2.8300 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.2236
Cell Significance Index: -4.4900 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: -0.2241
Cell Significance Index: -4.5600 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.2256
Cell Significance Index: -4.9400 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.2301
Cell Significance Index: -4.5500 - Cell Name: epithelial cell (CL0000066)
Fold Change: -0.2304
Cell Significance Index: -2.4300 - Cell Name: photoreceptor cell (CL0000210)
Fold Change: -0.2321
Cell Significance Index: -3.2600 - Cell Name: lymphocyte (CL0000542)
Fold Change: -0.2323
Cell Significance Index: -3.1600 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.2327
Cell Significance Index: -3.9000 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -0.2360
Cell Significance Index: -4.0800 - Cell Name: acinar cell (CL0000622)
Fold Change: -0.2404
Cell Significance Index: -3.0200 - Cell Name: hippocampal astrocyte (CL0002604)
Fold Change: -0.2431
Cell Significance Index: -3.4000 - Cell Name: glandular epithelial cell (CL0000150)
Fold Change: -0.2551
Cell Significance Index: -2.0300 - Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.2598
Cell Significance Index: -5.0800 - Cell Name: hippocampal interneuron (CL1001569)
Fold Change: -0.2629
Cell Significance Index: -3.4100 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -0.2655
Cell Significance Index: -3.4000
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 4108265738
Symbol: FIBB_HUMAN
Name: Fibrinogen beta chain
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 6688356
Title: Characterization of complementary deoxyribonucleic acid and genomic deoxyribonucleic acid for the beta chain of human fibrinogen.
PubMed ID: 6688356
DOI: 10.1021/bi00282a032
PubMed ID: 2102623
Title: Nucleotide sequences of the three genes coding for human fibrinogen.
PubMed ID: 2102623
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 6575700
Title: Cloning of fibrinogen genes and their cDNA.
PubMed ID: 6575700
PubMed ID: 3029722
Title: Characterization of the 5'-flanking region for the human fibrinogen beta gene.
PubMed ID: 3029722
PubMed ID: 420779
Title: Amino acid sequence of the beta chain of human fibrinogen.
PubMed ID: 420779
DOI: 10.1021/bi00568a011
PubMed ID: 936108
Title: Disulfide bridges in NH2-terminal part of human fibrinogen.
PubMed ID: 936108
PubMed ID: 12665801
Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.
PubMed ID: 12665801
DOI: 10.1038/nbt810
PubMed ID: 6575689
PubMed ID: 891553
Title: Primary structure of human fibrinogen. Characterization of disulfide-containing cyanogen-bromide fragments.
PubMed ID: 891553
PubMed ID: 6383194
PubMed ID: 7642629
Title: The interaction of fibulin-1 with fibrinogen. A potential role in hemostasis and thrombosis.
PubMed ID: 7642629
PubMed ID: 16335952
Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.
PubMed ID: 16335952
DOI: 10.1021/pr0502065
PubMed ID: 16263699
Title: Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach.
PubMed ID: 16263699
PubMed ID: 19159218
Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
PubMed ID: 19159218
DOI: 10.1021/pr8008012
PubMed ID: 2143188
Title: A unique proteolytic fragment of human fibrinogen containing the A alpha COOH-terminal domain of the native molecule.
PubMed ID: 2143188
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 9333233
Title: Crystal structures of fragment D from human fibrinogen and its crosslinked counterpart from fibrin.
PubMed ID: 9333233
DOI: 10.1038/38947
PubMed ID: 9628725
Title: Crystal structure of fragment double-D from human fibrin with two different bound ligands.
PubMed ID: 9628725
DOI: 10.1021/bi9804129
PubMed ID: 10074346
Title: Conformational changes in fragments D and double-D from human fibrin(ogen) upon binding the peptide ligand Gly-His-Arg-Pro-amide.
PubMed ID: 10074346
DOI: 10.1021/bi982626w
PubMed ID: 19296670
PubMed ID: 3194892
Title: A polymorphism at B beta 448 of fibrinogen identified during structural studies of fibrinogen Baltimore II.
PubMed ID: 3194892
PubMed ID: 2018836
Title: A new congenital abnormal fibrinogen Ise characterized by the replacement of B beta glycine-15 by cysteine.
PubMed ID: 2018836
PubMed ID: 1634610
Title: Molecular basis of fibrinogen Naples associated with defective thrombin binding and thrombophilia. Homozygous substitution of B beta 68 Ala-->Thr.
PubMed ID: 1634610
DOI: 10.1172/jci115841
PubMed ID: 1565641
Title: Abnormal fibrinogens IJmuiden (B beta Arg14-->Cys) and Nijmegen (B beta Arg44-->Cys) form disulfide-linked fibrinogen-albumin complexes.
PubMed ID: 1565641
PubMed ID: 3156856
Title: Characterization of fibrinogen New York 1. A dysfunctional fibrinogen with a deletion of B beta(9-72) corresponding exactly to exon 2 of the gene.
PubMed ID: 3156856
PubMed ID: 10391209
Title: Characterization of single-nucleotide polymorphisms in coding regions of human genes.
PubMed ID: 10391209
DOI: 10.1038/10290
PubMed ID: 10666208
Title: Missense mutations in the human beta fibrinogen gene cause congenital afibrinogenemia by impairing fibrinogen secretion.
PubMed ID: 10666208
PubMed ID: 11468164
Title: The impaired polymerization of fibrinogen Longmont (Bbeta166Arg-->Cys) is not improved by removal of disulfide-linked dimers from a mixture of dimers and cysteine-linked monomers.
PubMed ID: 11468164
PubMed ID: 15070683
Title: Missense or splicing mutation? The case of a fibrinogen Bbeta-chain mutation causing severe hypofibrinogenemia.
PubMed ID: 15070683
PubMed ID: 25427968
Title: Clinical and molecular characterisation of 21 patients affected by quantitative fibrinogen deficiency.
PubMed ID: 25427968
DOI: 10.1160/th14-07-0629
Sequence Information:
- Length: 491
- Mass: 55928
- Checksum: B92FFB9976AB53C5
- Sequence:
MKRMVSWSFH KLKTMKHLLL LLLCVFLVKS QGVNDNEEGF FSARGHRPLD KKREEAPSLR PAPPPISGGG YRARPAKAAA TQKKVERKAP DAGGCLHADP DLGVLCPTGC QLQEALLQQE RPIRNSVDEL NNNVEAVSQT SSSSFQYMYL LKDLWQKRQK QVKDNENVVN EYSSELEKHQ LYIDETVNSN IPTNLRVLRS ILENLRSKIQ KLESDVSAQM EYCRTPCTVS CNIPVVSGKE CEEIIRKGGE TSEMYLIQPD SSVKPYRVYC DMNTENGGWT VIQNRQDGSV DFGRKWDPYK QGFGNVATNT DGKNYCGLPG EYWLGNDKIS QLTRMGPTEL LIEMEDWKGD KVKAHYGGFT VQNEANKYQI SVNKYRGTAG NALMDGASQL MGENRTMTIH NGMFFSTYDR DNDGWLTSDP RKQCSKEDGG GWWYNRCHAA NPNGRYYWGG QYTWDMAKHG TDDGVVWMNW KGSWYSMRKM SMKIRPFFPQ Q
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.