Details for: FGB

Gene ID: 2244

Symbol: FGB

Ensembl ID: ENSG00000171564

Description: fibrinogen beta chain

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 23.9802
    Cell Significance Index: -3.7300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 18.2945
    Cell Significance Index: 308.1700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 14.7057
    Cell Significance Index: -3.7300
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 6.0249
    Cell Significance Index: 16.1400
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 4.5790
    Cell Significance Index: 15.9300
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 4.4532
    Cell Significance Index: 25.6500
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 4.2456
    Cell Significance Index: 15.9900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 4.1255
    Cell Significance Index: 818.7100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 3.2115
    Cell Significance Index: 328.0600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 2.5122
    Cell Significance Index: 37.0800
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 2.4149
    Cell Significance Index: 19.0700
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 2.3806
    Cell Significance Index: 6.2800
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.7793
    Cell Significance Index: 17.5600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.1701
    Cell Significance Index: 19.6800
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.9556
    Cell Significance Index: 6.2200
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.9509
    Cell Significance Index: 7.2400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.6179
    Cell Significance Index: 385.8900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.4847
    Cell Significance Index: 11.7400
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.3850
    Cell Significance Index: 3.6600
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.2863
    Cell Significance Index: 2.6200
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.2424
    Cell Significance Index: 2.5000
  • Cell Name: colonocyte (CL1000347)
    Fold Change: 0.1780
    Cell Significance Index: 1.1000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1060
    Cell Significance Index: 2.8400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0937
    Cell Significance Index: 0.9700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0305
    Cell Significance Index: 3.5600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: 0.0090
    Cell Significance Index: 0.3700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0035
    Cell Significance Index: 2.6000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0032
    Cell Significance Index: 0.3700
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0009
    Cell Significance Index: -0.5000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0018
    Cell Significance Index: -0.0800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0021
    Cell Significance Index: -3.9500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0028
    Cell Significance Index: -5.2200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0033
    Cell Significance Index: -5.1400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0039
    Cell Significance Index: -5.2900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0044
    Cell Significance Index: -0.9300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0044
    Cell Significance Index: -3.3500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0055
    Cell Significance Index: -0.9400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0060
    Cell Significance Index: -0.6900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0123
    Cell Significance Index: -9.0100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0145
    Cell Significance Index: -0.3600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0159
    Cell Significance Index: -7.2100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0203
    Cell Significance Index: -4.0700
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: -0.0312
    Cell Significance Index: -0.2400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0321
    Cell Significance Index: -4.4100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0377
    Cell Significance Index: -4.8800
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.0431
    Cell Significance Index: -0.4000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0458
    Cell Significance Index: -3.4100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0606
    Cell Significance Index: -8.8100
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0631
    Cell Significance Index: -0.6700
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0727
    Cell Significance Index: -1.0400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0824
    Cell Significance Index: -1.1800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0855
    Cell Significance Index: -5.2400
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0975
    Cell Significance Index: -1.2800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0984
    Cell Significance Index: -5.5200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1057
    Cell Significance Index: -4.9300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1059
    Cell Significance Index: -5.5000
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.1104
    Cell Significance Index: -1.8200
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1140
    Cell Significance Index: -1.6000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1140
    Cell Significance Index: -3.6300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1176
    Cell Significance Index: -4.1200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1179
    Cell Significance Index: -9.3400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1206
    Cell Significance Index: -5.6700
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.1211
    Cell Significance Index: -0.8800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1215
    Cell Significance Index: -4.4600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1249
    Cell Significance Index: -4.0900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1289
    Cell Significance Index: -3.3900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1319
    Cell Significance Index: -3.3600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1469
    Cell Significance Index: -3.6700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1541
    Cell Significance Index: -3.7600
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.1561
    Cell Significance Index: -1.3300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1586
    Cell Significance Index: -4.5500
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: -0.1594
    Cell Significance Index: -1.7300
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.1697
    Cell Significance Index: -2.1500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1700
    Cell Significance Index: -2.5100
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.1747
    Cell Significance Index: -1.8100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1893
    Cell Significance Index: -4.0900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1916
    Cell Significance Index: -3.8200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1920
    Cell Significance Index: -10.0000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1927
    Cell Significance Index: -4.0900
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: -0.2031
    Cell Significance Index: -1.9500
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.2099
    Cell Significance Index: -2.2800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2145
    Cell Significance Index: -5.3500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2151
    Cell Significance Index: -5.7400
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.2210
    Cell Significance Index: -2.8300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2236
    Cell Significance Index: -4.4900
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.2241
    Cell Significance Index: -4.5600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2256
    Cell Significance Index: -4.9400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2301
    Cell Significance Index: -4.5500
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.2304
    Cell Significance Index: -2.4300
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.2321
    Cell Significance Index: -3.2600
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.2323
    Cell Significance Index: -3.1600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2327
    Cell Significance Index: -3.9000
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.2360
    Cell Significance Index: -4.0800
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.2404
    Cell Significance Index: -3.0200
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.2431
    Cell Significance Index: -3.4000
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.2551
    Cell Significance Index: -2.0300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2598
    Cell Significance Index: -5.0800
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.2629
    Cell Significance Index: -3.4100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.2655
    Cell Significance Index: -3.4000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structural Protein:** FGB is a subunit of the fibrinogen complex, which is a crucial component of blood clot formation. It is composed of three subunits: alpha, beta, and gamma. 2. **Cell Adhesion Molecule:** FGB interacts with various cell adhesion molecules, such as integrins, to regulate cell-cell and cell-extracellular matrix interactions. 3. **Signaling Molecule:** FGB can bind to growth factor receptors and second messengers, influencing signaling pathways involved in immune response, cell growth, and differentiation. **Pathways and Functions:** 1. **Coagulation Cascade:** FGB is a key component of the coagulation cascade, where it interacts with thrombin to form fibrin clots. 2. **Immune Response:** FGB is involved in the adaptive immune response, where it is expressed on the surface of endothelial cells and macrophages, facilitating antigen presentation and immune cell activation. 3. **Cell Adhesion:** FGB interacts with integrins to regulate cell adhesion, migration, and proliferation. 4. **Signaling Pathways:** FGB can activate various signaling pathways, including MAPK, PI3K/AKT, and ERK, which regulate cell growth, differentiation, and survival. **Clinical Significance:** 1. **Thrombotic Disorders:** Abnormalities in FGB expression and function have been linked to thrombotic disorders, such as deep vein thrombosis and pulmonary embolism. 2. **Inflammatory Diseases:** FGB is involved in the regulation of inflammatory responses, and its dysregulation has been implicated in various inflammatory diseases, including atherosclerosis and rheumatoid arthritis. 3. **Cancer:** FGB can promote tumor growth and metastasis by regulating cell adhesion, migration, and signaling pathways. 4. **Neurological Disorders:** FGB has been implicated in the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease, where it regulates cell adhesion, migration, and signaling pathways. In conclusion, the fibrinogen beta chain is a multifaceted protein that plays a crucial role in various biological processes, including coagulation, immune response, and cell adhesion. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its mechanisms of action and regulation. Further research is needed to elucidate the complex interactions between FGB and other proteins to develop novel therapeutic strategies for the treatment of these diseases.

Genular Protein ID: 4108265738

Symbol: FIBB_HUMAN

Name: Fibrinogen beta chain

UniProtKB Accession Codes:

P02675 A0JLR9 B2R7G3 Q32Q65 Q3KPF2

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CPTAC 3 CTD 1 CarbonylDB 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 7 EMBL 14 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 41 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 2 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OGP 1 OMA 1 OpenTargets 1 Orphanet 4 OrthoDB 1 PANTHER 2 PDB 40 PDBsum 40 PIR 1 PRIDE 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 2 RNAct 1 Reactome 18 RefSeq 2 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UniLectin 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 6688356

Title: Characterization of complementary deoxyribonucleic acid and genomic deoxyribonucleic acid for the beta chain of human fibrinogen.

PubMed ID: 6688356

DOI: 10.1021/bi00282a032

PubMed ID: 2102623

Title: Nucleotide sequences of the three genes coding for human fibrinogen.

PubMed ID: 2102623

DOI: 10.1007/978-1-4615-3806-6_3

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 6575700

Title: Cloning of fibrinogen genes and their cDNA.

PubMed ID: 6575700

DOI: 10.1111/j.1749-6632.1983.tb23265.x

PubMed ID: 3029722

Title: Characterization of the 5'-flanking region for the human fibrinogen beta gene.

PubMed ID: 3029722

DOI: 10.1093/nar/15.4.1615

PubMed ID: 420779

Title: Amino acid sequence of the beta chain of human fibrinogen.

PubMed ID: 420779

DOI: 10.1021/bi00568a011

PubMed ID: 936108

Title: Disulfide bridges in NH2-terminal part of human fibrinogen.

PubMed ID: 936108

DOI: 10.1016/0049-3848(76)90245-0

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 6575689

Title: Covalent structure of fibrinogen.

PubMed ID: 6575689

DOI: 10.1111/j.1749-6632.1983.tb23232.x

PubMed ID: 891553

Title: Primary structure of human fibrinogen. Characterization of disulfide-containing cyanogen-bromide fragments.

PubMed ID: 891553

DOI: 10.1111/j.1432-1033.1977.tb11704.x

PubMed ID: 6383194

Title: Fibrinogen and fibrin.

PubMed ID: 6383194

DOI: 10.1146/annurev.bi.53.070184.001211

PubMed ID: 7642629

Title: The interaction of fibulin-1 with fibrinogen. A potential role in hemostasis and thrombosis.

PubMed ID: 7642629

DOI: 10.1074/jbc.270.33.19458

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 16263699

Title: Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach.

PubMed ID: 16263699

DOI: 10.1074/mcp.m500324-mcp200

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 2143188

Title: A unique proteolytic fragment of human fibrinogen containing the A alpha COOH-terminal domain of the native molecule.

PubMed ID: 2143188

DOI: 10.1016/s0021-9258(18)77401-2

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 9333233

Title: Crystal structures of fragment D from human fibrinogen and its crosslinked counterpart from fibrin.

PubMed ID: 9333233

DOI: 10.1038/38947

PubMed ID: 9628725

Title: Crystal structure of fragment double-D from human fibrin with two different bound ligands.

PubMed ID: 9628725

DOI: 10.1021/bi9804129

PubMed ID: 10074346

Title: Conformational changes in fragments D and double-D from human fibrin(ogen) upon binding the peptide ligand Gly-His-Arg-Pro-amide.

PubMed ID: 10074346

DOI: 10.1021/bi982626w

PubMed ID: 19296670

Title: Crystal structure of human fibrinogen.

PubMed ID: 19296670

DOI: 10.1021/bi802205g

PubMed ID: 3194892

Title: A polymorphism at B beta 448 of fibrinogen identified during structural studies of fibrinogen Baltimore II.

PubMed ID: 3194892

DOI: 10.1016/0049-3848(88)90096-5

PubMed ID: 2018836

Title: A new congenital abnormal fibrinogen Ise characterized by the replacement of B beta glycine-15 by cysteine.

PubMed ID: 2018836

PubMed ID: 1634610

Title: Molecular basis of fibrinogen Naples associated with defective thrombin binding and thrombophilia. Homozygous substitution of B beta 68 Ala-->Thr.

PubMed ID: 1634610

DOI: 10.1172/jci115841

PubMed ID: 1565641

Title: Abnormal fibrinogens IJmuiden (B beta Arg14-->Cys) and Nijmegen (B beta Arg44-->Cys) form disulfide-linked fibrinogen-albumin complexes.

PubMed ID: 1565641

DOI: 10.1073/pnas.89.8.3478

PubMed ID: 3156856

Title: Characterization of fibrinogen New York 1. A dysfunctional fibrinogen with a deletion of B beta(9-72) corresponding exactly to exon 2 of the gene.

PubMed ID: 3156856

DOI: 10.1016/s0021-9258(18)89277-8

PubMed ID: 10391209

Title: Characterization of single-nucleotide polymorphisms in coding regions of human genes.

PubMed ID: 10391209

DOI: 10.1038/10290

PubMed ID: 10666208

Title: Missense mutations in the human beta fibrinogen gene cause congenital afibrinogenemia by impairing fibrinogen secretion.

PubMed ID: 10666208

PubMed ID: 11468164

Title: The impaired polymerization of fibrinogen Longmont (Bbeta166Arg-->Cys) is not improved by removal of disulfide-linked dimers from a mixture of dimers and cysteine-linked monomers.

PubMed ID: 11468164

DOI: 10.1182/blood.v98.3.661

PubMed ID: 15070683

Title: Missense or splicing mutation? The case of a fibrinogen Bbeta-chain mutation causing severe hypofibrinogenemia.

PubMed ID: 15070683

DOI: 10.1182/blood-2003-10-3725

PubMed ID: 25427968

Title: Clinical and molecular characterisation of 21 patients affected by quantitative fibrinogen deficiency.

PubMed ID: 25427968

DOI: 10.1160/th14-07-0629

Sequence Information:

  • Length: 491
  • Mass: 55928
  • Checksum: B92FFB9976AB53C5
  • Sequence:
    • MKRMVSWSFH KLKTMKHLLL LLLCVFLVKS QGVNDNEEGF FSARGHRPLD KKREEAPSLR 
PAPPPISGGG YRARPAKAAA TQKKVERKAP DAGGCLHADP DLGVLCPTGC QLQEALLQQE 
RPIRNSVDEL NNNVEAVSQT SSSSFQYMYL LKDLWQKRQK QVKDNENVVN EYSSELEKHQ 
LYIDETVNSN IPTNLRVLRS ILENLRSKIQ KLESDVSAQM EYCRTPCTVS CNIPVVSGKE 
CEEIIRKGGE TSEMYLIQPD SSVKPYRVYC DMNTENGGWT VIQNRQDGSV DFGRKWDPYK 
QGFGNVATNT DGKNYCGLPG EYWLGNDKIS QLTRMGPTEL LIEMEDWKGD KVKAHYGGFT 
VQNEANKYQI SVNKYRGTAG NALMDGASQL MGENRTMTIH NGMFFSTYDR DNDGWLTSDP 
RKQCSKEDGG GWWYNRCHAA NPNGRYYWGG QYTWDMAKHG TDDGVVWMNW KGSWYSMRKM 
SMKIRPFFPQ Q

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.