Details for: FGB

Gene ID: 2244

Symbol: FGB

Ensembl ID: ENSG00000171564

Description: fibrinogen beta chain

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 11.01
    Marker Score: 36054
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 8.22
    Marker Score: 12668
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 4.04
    Marker Score: 21741
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 2.75
    Marker Score: 2949
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 2.62
    Marker Score: 812
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 2.4
    Marker Score: 10373
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 2.4
    Marker Score: 15437
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 2.32
    Marker Score: 4224
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 1.79
    Marker Score: 493
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.69
    Marker Score: 371
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.65
    Marker Score: 686
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.61
    Marker Score: 1100
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.57
    Marker Score: 1573.5
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.55
    Marker Score: 3685
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.18
    Marker Score: 444
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.15
    Marker Score: 7674
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.05
    Marker Score: 6384
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 1.03
    Marker Score: 1675
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71816
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48041
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.95
    Marker Score: 1543
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5345
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.84
    Marker Score: 525
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 707
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.73
    Marker Score: 554
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.66
    Marker Score: 384
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.62
    Marker Score: 8280
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.6
    Marker Score: 568
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.59
    Marker Score: 468
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.57
    Marker Score: 125
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.57
    Marker Score: 544
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.55
    Marker Score: 555
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.52
    Marker Score: 464
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.5
    Marker Score: 188
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.49
    Marker Score: 542
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 275
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.45
    Marker Score: 206
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 0.45
    Marker Score: 1005
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.44
    Marker Score: 494
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.44
    Marker Score: 204
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.41
    Marker Score: 210
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.4
    Marker Score: 686
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.39
    Marker Score: 372
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.38
    Marker Score: 2442.5
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.38
    Marker Score: 1332
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.36
    Marker Score: 156
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.35
    Marker Score: 160
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.33
    Marker Score: 183
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 0.3
    Marker Score: 74
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.29
    Marker Score: 505.5
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.28
    Marker Score: 149
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.28
    Marker Score: 248
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.27
    Marker Score: 428
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.27
    Marker Score: 179
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.27
    Marker Score: 69
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.24
    Marker Score: 594
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.24
    Marker Score: 101
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.21
    Marker Score: 76.5
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.21
    Marker Score: 133
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.21
    Marker Score: 402
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.21
    Marker Score: 210
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.21
    Marker Score: 47
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.21
    Marker Score: 201
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.18
    Marker Score: 203
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.18
    Marker Score: 61
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.18
    Marker Score: 359
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.18
    Marker Score: 188
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.17
    Marker Score: 254
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.17
    Marker Score: 61
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.16
    Marker Score: 170
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.16
    Marker Score: 370
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.15
    Marker Score: 132
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.15
    Marker Score: 125
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.15
    Marker Score: 158
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.14
    Marker Score: 79
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 0.14
    Marker Score: 31
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.14
    Marker Score: 34
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.13
    Marker Score: 34
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.13
    Marker Score: 270
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.13
    Marker Score: 34
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.13
    Marker Score: 136
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.13
    Marker Score: 34
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.13
    Marker Score: 33
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.13
    Marker Score: 163
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.13
    Marker Score: 1967
  • Cell Name: CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human (CL0001074)
    Fold Change: 0.12
    Marker Score: 33
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.12
    Marker Score: 58
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.12
    Marker Score: 199
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.12
    Marker Score: 693
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.11
    Marker Score: 69
  • Cell Name: parietal cell (CL0000162)
    Fold Change: 0.11
    Marker Score: 31
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.11
    Marker Score: 76
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.11
    Marker Score: 58
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 0.11
    Marker Score: 90
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.11
    Marker Score: 102
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.11
    Marker Score: 32

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Other Information

**Key characteristics:** * The FGB gene is located on chromosome 15q21.1. * It is a single-exon gene with a length of approximately 2.6 kb. * The FGB protein is a glycoprotein with a molecular weight of approximately 140 kDa. **Pathways and functions:** * The FGB gene is involved in the adaptive immune system and the common pathway of fibrin clot formation. * It is a key factor in the formation of fibrin clots, which are essential for hemostasis and tissue repair. * The FGB gene is also involved in the regulation of inflammation and immune responses. **Clinical significance:** * Mutations in the FGB gene are associated with several human diseases, including hemophilia A and von Willebrand disease. * These diseases are caused by mutations in the FGB gene that result in reduced or absent production of fibrinogen, leading to impaired blood clotting. * Gene therapy approaches aimed at correcting FGB mutations are being investigated as potential treatments for these diseases. **Additional notes:** * The FGB gene is also involved in the regulation of platelet activation, aggregation, and signaling. * It is a key regulator of vascular permeability and inflammation. * The FGB gene is also involved in the regulation of immune responses to injury and infection.

Genular Protein ID: 4108265738

Symbol: FIBB_HUMAN

Name: Fibrinogen beta chain

UniProtKB Accession Codes:

P02675 A0JLR9 B2R7G3 Q32Q65 Q3KPF2

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CPTAC 3 CTD 1 CarbonylDB 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DOSAC-COBS-2DPAGE 1 DisGeNET 1 DrugBank 7 EMBL 14 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 41 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 2 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OGP 1 OMA 1 OpenTargets 1 Orphanet 4 OrthoDB 1 PANTHER 2 PDB 54 PDBsum 40 PIR 1 PRIDE 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 2 RNAct 1 Reactome 18 RefSeq 2 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SWISS-2DPAGE 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCD-2DPAGE 1 UniLectin 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 6688356

Title: Characterization of complementary deoxyribonucleic acid and genomic deoxyribonucleic acid for the beta chain of human fibrinogen.

PubMed ID: 6688356

DOI: 10.1021/bi00282a032

PubMed ID: 2102623

Title: Nucleotide sequences of the three genes coding for human fibrinogen.

PubMed ID: 2102623

DOI: 10.1007/978-1-4615-3806-6_3

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 6575700

Title: Cloning of fibrinogen genes and their cDNA.

PubMed ID: 6575700

DOI: 10.1111/j.1749-6632.1983.tb23265.x

PubMed ID: 3029722

Title: Characterization of the 5'-flanking region for the human fibrinogen beta gene.

PubMed ID: 3029722

DOI: 10.1093/nar/15.4.1615

PubMed ID: 420779

Title: Amino acid sequence of the beta chain of human fibrinogen.

PubMed ID: 420779

DOI: 10.1021/bi00568a011

PubMed ID: 936108

Title: Disulfide bridges in NH2-terminal part of human fibrinogen.

PubMed ID: 936108

DOI: 10.1016/0049-3848(76)90245-0

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 6575689

Title: Covalent structure of fibrinogen.

PubMed ID: 6575689

DOI: 10.1111/j.1749-6632.1983.tb23232.x

PubMed ID: 891553

Title: Primary structure of human fibrinogen. Characterization of disulfide-containing cyanogen-bromide fragments.

PubMed ID: 891553

DOI: 10.1111/j.1432-1033.1977.tb11704.x

PubMed ID: 6383194

Title: Fibrinogen and fibrin.

PubMed ID: 6383194

DOI: 10.1146/annurev.bi.53.070184.001211

PubMed ID: 7642629

Title: The interaction of fibulin-1 with fibrinogen. A potential role in hemostasis and thrombosis.

PubMed ID: 7642629

DOI: 10.1074/jbc.270.33.19458

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 16263699

Title: Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach.

PubMed ID: 16263699

DOI: 10.1074/mcp.m500324-mcp200

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 2143188

Title: A unique proteolytic fragment of human fibrinogen containing the A alpha COOH-terminal domain of the native molecule.

PubMed ID: 2143188

DOI: 10.1016/s0021-9258(18)77401-2

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 9333233

Title: Crystal structures of fragment D from human fibrinogen and its crosslinked counterpart from fibrin.

PubMed ID: 9333233

DOI: 10.1038/38947

PubMed ID: 9628725

Title: Crystal structure of fragment double-D from human fibrin with two different bound ligands.

PubMed ID: 9628725

DOI: 10.1021/bi9804129

PubMed ID: 10074346

Title: Conformational changes in fragments D and double-D from human fibrin(ogen) upon binding the peptide ligand Gly-His-Arg-Pro-amide.

PubMed ID: 10074346

DOI: 10.1021/bi982626w

PubMed ID: 19296670

Title: Crystal structure of human fibrinogen.

PubMed ID: 19296670

DOI: 10.1021/bi802205g

PubMed ID: 3194892

Title: A polymorphism at B beta 448 of fibrinogen identified during structural studies of fibrinogen Baltimore II.

PubMed ID: 3194892

DOI: 10.1016/0049-3848(88)90096-5

PubMed ID: 2018836

Title: A new congenital abnormal fibrinogen Ise characterized by the replacement of B beta glycine-15 by cysteine.

PubMed ID: 2018836

PubMed ID: 1634610

Title: Molecular basis of fibrinogen Naples associated with defective thrombin binding and thrombophilia. Homozygous substitution of B beta 68 Ala-->Thr.

PubMed ID: 1634610

DOI: 10.1172/jci115841

PubMed ID: 1565641

Title: Abnormal fibrinogens IJmuiden (B beta Arg14-->Cys) and Nijmegen (B beta Arg44-->Cys) form disulfide-linked fibrinogen-albumin complexes.

PubMed ID: 1565641

DOI: 10.1073/pnas.89.8.3478

PubMed ID: 3156856

Title: Characterization of fibrinogen New York 1. A dysfunctional fibrinogen with a deletion of B beta(9-72) corresponding exactly to exon 2 of the gene.

PubMed ID: 3156856

DOI: 10.1016/s0021-9258(18)89277-8

PubMed ID: 10391209

Title: Characterization of single-nucleotide polymorphisms in coding regions of human genes.

PubMed ID: 10391209

DOI: 10.1038/10290

PubMed ID: 10666208

Title: Missense mutations in the human beta fibrinogen gene cause congenital afibrinogenemia by impairing fibrinogen secretion.

PubMed ID: 10666208

PubMed ID: 11468164

Title: The impaired polymerization of fibrinogen Longmont (Bbeta166Arg-->Cys) is not improved by removal of disulfide-linked dimers from a mixture of dimers and cysteine-linked monomers.

PubMed ID: 11468164

DOI: 10.1182/blood.v98.3.661

PubMed ID: 15070683

Title: Missense or splicing mutation? The case of a fibrinogen Bbeta-chain mutation causing severe hypofibrinogenemia.

PubMed ID: 15070683

DOI: 10.1182/blood-2003-10-3725

PubMed ID: 25427968

Title: Clinical and molecular characterisation of 21 patients affected by quantitative fibrinogen deficiency.

PubMed ID: 25427968

DOI: 10.1160/th14-07-0629

Sequence Information:

  • Length: 491
  • Mass: 55928
  • Checksum: B92FFB9976AB53C5
  • Sequence:
    • MKRMVSWSFH KLKTMKHLLL LLLCVFLVKS QGVNDNEEGF FSARGHRPLD KKREEAPSLR 
PAPPPISGGG YRARPAKAAA TQKKVERKAP DAGGCLHADP DLGVLCPTGC QLQEALLQQE 
RPIRNSVDEL NNNVEAVSQT SSSSFQYMYL LKDLWQKRQK QVKDNENVVN EYSSELEKHQ 
LYIDETVNSN IPTNLRVLRS ILENLRSKIQ KLESDVSAQM EYCRTPCTVS CNIPVVSGKE 
CEEIIRKGGE TSEMYLIQPD SSVKPYRVYC DMNTENGGWT VIQNRQDGSV DFGRKWDPYK 
QGFGNVATNT DGKNYCGLPG EYWLGNDKIS QLTRMGPTEL LIEMEDWKGD KVKAHYGGFT 
VQNEANKYQI SVNKYRGTAG NALMDGASQL MGENRTMTIH NGMFFSTYDR DNDGWLTSDP 
RKQCSKEDGG GWWYNRCHAA NPNGRYYWGG QYTWDMAKHG TDDGVVWMNW KGSWYSMRKM 
SMKIRPFFPQ Q

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.