Details for: CL0000188

Cell ID: CL0000188

Cell Name: cell of skeletal muscle

Marker Score Threshold: 761
(Derived using integrated single-cell and genomic data)

Description: A somatic cell located in skeletal muscle.

Synonyms: skeletal muscle cell

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTC1 (ENSG00000159251)
    Fold Change: 11.32
    Ensembl ID: ENSG00000159251
  • Gene Symbol: CKM (ENSG00000104879)
    Fold Change: 8.85
    Ensembl ID: ENSG00000104879
  • Gene Symbol: ACTN2 (ENSG00000077522)
    Fold Change: 7.62
    Ensembl ID: ENSG00000077522
  • Gene Symbol: CASQ2 (ENSG00000118729)
    Fold Change: 5.2
    Ensembl ID: ENSG00000118729
  • Gene Symbol: CASQ1 (ENSG00000143318)
    Fold Change: 4.68
    Ensembl ID: ENSG00000143318
  • Gene Symbol: ANK2 (ENSG00000145362)
    Fold Change: 4.6
    Ensembl ID: ENSG00000145362
  • Gene Symbol: AGL (ENSG00000162688)
    Fold Change: 4.27
    Ensembl ID: ENSG00000162688
  • Gene Symbol: COL1A2 (ENSG00000164692)
    Fold Change: 4.17
    Ensembl ID: ENSG00000164692
  • Gene Symbol: CACNA2D1 (ENSG00000153956)
    Fold Change: 4.13
    Ensembl ID: ENSG00000153956
  • Gene Symbol: CA3 (ENSG00000164879)
    Fold Change: 4.04
    Ensembl ID: ENSG00000164879
  • Gene Symbol: COL3A1 (ENSG00000168542)
    Fold Change: 4
    Ensembl ID: ENSG00000168542
  • Gene Symbol: ATP2A1 (ENSG00000196296)
    Fold Change: 3.7
    Ensembl ID: ENSG00000196296
  • Gene Symbol: COL1A1 (ENSG00000108821)
    Fold Change: 3.58
    Ensembl ID: ENSG00000108821
  • Gene Symbol: AK1 (ENSG00000106992)
    Fold Change: 3.47
    Ensembl ID: ENSG00000106992
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 3.47
    Ensembl ID: ENSG00000149925
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 3.44
    Ensembl ID: ENSG00000145741
  • Gene Symbol: CAMK2D (ENSG00000145349)
    Fold Change: 3.15
    Ensembl ID: ENSG00000145349
  • Gene Symbol: CAV3 (ENSG00000182533)
    Fold Change: 2.84
    Ensembl ID: ENSG00000182533
  • Gene Symbol: CD36 (ENSG00000135218)
    Fold Change: 2.83
    Ensembl ID: ENSG00000135218
  • Gene Symbol: ANK3 (ENSG00000151150)
    Fold Change: 2.76
    Ensembl ID: ENSG00000151150
  • Gene Symbol: CAPN6 (ENSG00000077274)
    Fold Change: 2.76
    Ensembl ID: ENSG00000077274
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.7
    Ensembl ID: ENSG00000169100
  • Gene Symbol: CACNG1 (ENSG00000108878)
    Fold Change: 2.68
    Ensembl ID: ENSG00000108878
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 2.54
    Ensembl ID: ENSG00000135404
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 2.44
    Ensembl ID: ENSG00000172757
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 2.24
    Ensembl ID: ENSG00000174437
  • Gene Symbol: COX4I1 (ENSG00000131143)
    Fold Change: 2.23
    Ensembl ID: ENSG00000131143
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.18
    Ensembl ID: ENSG00000124172
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 2.18
    Ensembl ID: ENSG00000151914
  • Gene Symbol: CDH13 (ENSG00000140945)
    Fold Change: 2.18
    Ensembl ID: ENSG00000140945
  • Gene Symbol: BIN1 (ENSG00000136717)
    Fold Change: 2.06
    Ensembl ID: ENSG00000136717
  • Gene Symbol: COX6A2 (ENSG00000156885)
    Fold Change: 2.06
    Ensembl ID: ENSG00000156885
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 2.04
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.04
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ANK1 (ENSG00000029534)
    Fold Change: 1.99
    Ensembl ID: ENSG00000029534
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 1.96
    Ensembl ID: ENSG00000067560
  • Gene Symbol: CDH15 (ENSG00000129910)
    Fold Change: 1.95
    Ensembl ID: ENSG00000129910
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.92
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ALB (ENSG00000163631)
    Fold Change: 1.88
    Ensembl ID: ENSG00000163631
  • Gene Symbol: CAMK2A (ENSG00000070808)
    Fold Change: 1.88
    Ensembl ID: ENSG00000070808
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 1.85
    Ensembl ID: ENSG00000143933
  • Gene Symbol: COX6C (ENSG00000164919)
    Fold Change: 1.83
    Ensembl ID: ENSG00000164919
  • Gene Symbol: CDK6 (ENSG00000105810)
    Fold Change: 1.8
    Ensembl ID: ENSG00000105810
  • Gene Symbol: RUNX1T1 (ENSG00000079102)
    Fold Change: 1.79
    Ensembl ID: ENSG00000079102
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.79
    Ensembl ID: ENSG00000077549
  • Gene Symbol: CD81 (ENSG00000110651)
    Fold Change: 1.77
    Ensembl ID: ENSG00000110651
  • Gene Symbol: ADCY2 (ENSG00000078295)
    Fold Change: 1.68
    Ensembl ID: ENSG00000078295
  • Gene Symbol: BMPR2 (ENSG00000204217)
    Fold Change: 1.66
    Ensembl ID: ENSG00000204217
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 1.65
    Ensembl ID: ENSG00000099622
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.63
    Ensembl ID: ENSG00000142599
  • Gene Symbol: COX6B1 (ENSG00000126267)
    Fold Change: 1.61
    Ensembl ID: ENSG00000126267
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 1.61
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.6
    Ensembl ID: ENSG00000154518
  • Gene Symbol: CDKN1C (ENSG00000129757)
    Fold Change: 1.6
    Ensembl ID: ENSG00000129757
  • Gene Symbol: COX5B (ENSG00000135940)
    Fold Change: 1.57
    Ensembl ID: ENSG00000135940
  • Gene Symbol: CACNA1S (ENSG00000081248)
    Fold Change: 1.55
    Ensembl ID: ENSG00000081248
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.52
    Ensembl ID: ENSG00000179218
  • Gene Symbol: LRBA (ENSG00000198589)
    Fold Change: 1.52
    Ensembl ID: ENSG00000198589
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 1.49
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 1.45
    Ensembl ID: ENSG00000156110
  • Gene Symbol: FOXN3 (ENSG00000053254)
    Fold Change: 1.44
    Ensembl ID: ENSG00000053254
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.42
    Ensembl ID: ENSG00000154723
  • Gene Symbol: CNN3 (ENSG00000117519)
    Fold Change: 1.42
    Ensembl ID: ENSG00000117519
  • Gene Symbol: CALU (ENSG00000128595)
    Fold Change: 1.42
    Ensembl ID: ENSG00000128595
  • Gene Symbol: CAPNS1 (ENSG00000126247)
    Fold Change: 1.42
    Ensembl ID: ENSG00000126247
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.37
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.33
    Ensembl ID: ENSG00000152234
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.32
    Ensembl ID: ENSG00000169020
  • Gene Symbol: CDKN1A (ENSG00000124762)
    Fold Change: 1.31
    Ensembl ID: ENSG00000124762
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.29
    Ensembl ID: ENSG00000153113
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.29
    Ensembl ID: ENSG00000104763
  • Gene Symbol: CACNB1 (ENSG00000067191)
    Fold Change: 1.29
    Ensembl ID: ENSG00000067191
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 1.24
    Ensembl ID: ENSG00000070831
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 1.22
    Ensembl ID: ENSG00000198363
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.22
    Ensembl ID: ENSG00000197043
  • Gene Symbol: BCAT1 (ENSG00000060982)
    Fold Change: 1.2
    Ensembl ID: ENSG00000060982
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.19
    Ensembl ID: ENSG00000110955
  • Gene Symbol: CCNG1 (ENSG00000113328)
    Fold Change: 1.18
    Ensembl ID: ENSG00000113328
  • Gene Symbol: CHD4 (ENSG00000111642)
    Fold Change: 1.17
    Ensembl ID: ENSG00000111642
  • Gene Symbol: CFL2 (ENSG00000165410)
    Fold Change: 1.16
    Ensembl ID: ENSG00000165410
  • Gene Symbol: APC (ENSG00000134982)
    Fold Change: 1.15
    Ensembl ID: ENSG00000134982
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 1.13
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.12
    Ensembl ID: ENSG00000130402
  • Gene Symbol: XIAP (ENSG00000101966)
    Fold Change: 1.12
    Ensembl ID: ENSG00000101966
  • Gene Symbol: ACTN3 (ENSG00000248746)
    Fold Change: 1.11
    Ensembl ID: ENSG00000248746
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.1
    Ensembl ID: ENSG00000198898
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 1.09
    Ensembl ID: ENSG00000166710
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.09
    Ensembl ID: ENSG00000127022
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.09
    Ensembl ID: ENSG00000134825
  • Gene Symbol: KLF6 (ENSG00000067082)
    Fold Change: 1.07
    Ensembl ID: ENSG00000067082
  • Gene Symbol: SCARB2 (ENSG00000138760)
    Fold Change: 1.06
    Ensembl ID: ENSG00000138760
  • Gene Symbol: COL5A1 (ENSG00000130635)
    Fold Change: 1.06
    Ensembl ID: ENSG00000130635
  • Gene Symbol: COX6A1 (ENSG00000111775)
    Fold Change: 1.06
    Ensembl ID: ENSG00000111775
  • Gene Symbol: CHRND (ENSG00000135902)
    Fold Change: 1.04
    Ensembl ID: ENSG00000135902
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.03
    Ensembl ID: ENSG00000116459
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.03
    Ensembl ID: ENSG00000005022
  • Gene Symbol: CKB (ENSG00000166165)
    Fold Change: 1.02
    Ensembl ID: ENSG00000166165
  • Gene Symbol: CHRNA1 (ENSG00000138435)
    Fold Change: 1.02
    Ensembl ID: ENSG00000138435
  • Gene Symbol: ACYP2 (ENSG00000170634)
    Fold Change: 1.02
    Ensembl ID: ENSG00000170634
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 1
    Ensembl ID: ENSG00000184009
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Actin-myosin filaments**: Skeletal muscle cells contain actin-myosin filaments, which are essential for muscle contraction. 2. **Actin-binding proteins**: These cells express actin-binding proteins, such as ankyrin-2 (ANK2), which play a crucial role in maintaining the structural integrity of the sarcomere. 3. **Calcium ion homeostasis**: Skeletal muscle cells are involved in calcium ion homeostasis, which is essential for muscle contraction and cardiac conduction. 4. **Creatine metabolism**: These cells express genes involved in creatine metabolism, such as creatine kinase (CKM), which is essential for muscle contraction. 5. **Sarcomere organization**: Skeletal muscle cells contain sarcomeres, which are the functional units of skeletal muscle tissue. **Clinical Significance** 1. **Muscle disorders**: Skeletal muscle cells are involved in various muscle disorders, such as muscular dystrophy, which can result from mutations in genes involved in muscle contraction and calcium ion homeostasis. 2. **Cardiac conduction disorders**: Skeletal muscle cells are also involved in cardiac conduction disorders, such as atrial fibrillation, which can result from mutations in genes involved in calcium ion homeostasis and cardiac conduction. 3. **Muscle weakness**: Skeletal muscle cells are involved in muscle weakness, which can result from mutations in genes involved in muscle contraction and calcium ion homeostasis. 4. **Neuromuscular junction disorders**: Skeletal muscle cells are also involved in neuromuscular junction disorders, such as myasthenia gravis, which can result from mutations in genes involved in muscle contraction and calcium ion homeostasis. In conclusion, skeletal muscle cells are a type of somatic cell found in skeletal muscle tissue, which are characterized by the presence of actin-myosin filaments, actin-binding proteins, and genes involved in creatine metabolism. These cells are involved in various signaling pathways, including those related to calcium ion homeostasis, muscle contraction, and cardiac conduction. The clinical significance of skeletal muscle cells is evident in various muscle disorders, cardiac conduction disorders, muscle weakness, and neuromuscular junction disorders.