Details for: TP63

Gene ID: 8626

Symbol: TP63

Ensembl ID: ENSG00000073282

Description: tumor protein p63

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 7.24
    Marker Score: 23193
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 5.01
    Marker Score: 12552
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 3.78
    Marker Score: 4277
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 3.53
    Marker Score: 3132
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 3.07
    Marker Score: 2524
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 2.62
    Marker Score: 5413
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 2.35
    Marker Score: 1025
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.31
    Marker Score: 2557
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.91
    Marker Score: 646
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.76
    Marker Score: 13092
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.62
    Marker Score: 9731
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1170
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.5
    Marker Score: 1934
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 169185
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.42
    Marker Score: 5258
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 1.42
    Marker Score: 1078
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.34
    Marker Score: 2199.5
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 855
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.24
    Marker Score: 864
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.22
    Marker Score: 2480
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.21
    Marker Score: 244
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.17
    Marker Score: 487
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4808
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.13
    Marker Score: 1192
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.09
    Marker Score: 503
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.04
    Marker Score: 1535
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 796
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71820
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48044
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 509
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 462
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.98
    Marker Score: 586
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.94
    Marker Score: 233
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.94
    Marker Score: 8069
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5327
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 374
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.93
    Marker Score: 518.5
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2739
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 327
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.88
    Marker Score: 1015
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5286
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.87
    Marker Score: 13583
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1265
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 708
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.72
    Marker Score: 626
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 462
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 180
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.7
    Marker Score: 220
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.7
    Marker Score: 586
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.69
    Marker Score: 5412.5
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.67
    Marker Score: 2640
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.64
    Marker Score: 1504
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.63
    Marker Score: 3089
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.61
    Marker Score: 195
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 150
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.57
    Marker Score: 270
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.56
    Marker Score: 4775
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 175
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.54
    Marker Score: 151
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.52
    Marker Score: 1263
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.51
    Marker Score: 134
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.42
    Marker Score: 152
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.41
    Marker Score: 98
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.4
    Marker Score: 140
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.4
    Marker Score: 195
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.39
    Marker Score: 174
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.39
    Marker Score: 347
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.38
    Marker Score: 254
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.37
    Marker Score: 1520
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.34
    Marker Score: 127
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.34
    Marker Score: 87
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: 0.33
    Marker Score: 109
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.31
    Marker Score: 180
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.3
    Marker Score: 575
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.3
    Marker Score: 346
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.29
    Marker Score: 725
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.28
    Marker Score: 221
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.28
    Marker Score: 101
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.27
    Marker Score: 69
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.26
    Marker Score: 263
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.26
    Marker Score: 106
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.26
    Marker Score: 337
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.25
    Marker Score: 147
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.24
    Marker Score: 72
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.24
    Marker Score: 387.5
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.23
    Marker Score: 46
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 66
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.23
    Marker Score: 82
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.23
    Marker Score: 69
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.23
    Marker Score: 95
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.22
    Marker Score: 93
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 75
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.22
    Marker Score: 189
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.22
    Marker Score: 666
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.22
    Marker Score: 376

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Other Information

**Key Characteristics** TP63 is a transcription factor that belongs to the p53 family of proteins. It is a member of the basic helix-loop-helix (bHLH) family of transcription factors and is characterized by its ability to regulate gene expression through binding to specific DNA sequences. TP63 is highly expressed in tissues with epithelial and mesenchymal characteristics, including skin, craniofacial structures, and urogenital organs. The gene is highly conserved across species, suggesting its essential role in development and tissue homeostasis. **Pathways and Functions** TP63 regulates various cellular processes, including: 1. **Apoptosis**: TP63 can induce apoptosis in response to DNA damage, acting as a tumor suppressor gene. 2. **Cell cycle regulation**: TP63 regulates cell cycle progression and prevents uncontrolled cell growth. 3. **Differentiation**: TP63 regulates the differentiation of epithelial and mesenchymal cells. 4. **Senescence**: TP63 can induce senescence in damaged cells, preventing tumor formation. 5. **Transcriptional regulation**: TP63 regulates the expression of genes involved in cell growth, differentiation, and survival. TP63 interacts with other transcription factors and proteins to regulate gene expression. For example, TP63 interacts with p53 to regulate apoptosis and cell cycle regulation. **Clinical Significance** TP63 has been implicated in the development of various cancers, including: 1. **Squamous cell carcinomas**: TP63 mutations have been identified in squamous cell carcinomas of the skin, lung, and other organs. 2. **Basal cell carcinomas**: TP63 mutations have been identified in basal cell carcinomas of the skin. 3. **Cancer therapy**: TP63 has been identified as a target for cancer therapy, with potential applications in cancer treatment and prevention. In addition to its role in cancer, TP63 has been implicated in other diseases, including: 1. **Neurological disorders**: TP63 has been implicated in the development of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 2. **Muscular dystrophy**: TP63 has been implicated in the development of muscular dystrophy. 3. **Cardiovascular disease**: TP63 has been implicated in the development of cardiovascular disease. Overall, TP63 is a critical gene involved in various cellular processes, including development, differentiation, and survival. Its dysregulation has been implicated in the development of various cancers and other diseases, highlighting its importance in human health and disease.

Genular Protein ID: 3965160155

Symbol: P63_HUMAN

Name: Tumor protein 63

UniProtKB Accession Codes:

Q9H3D4 O75080 O75195 O75922 O76078 Q6VEG2 Q6VEG3 Q6VEG4 Q6VFJ1 Q6VFJ2 Q6VFJ3 Q6VH20 Q7LDI3 Q7LDI4 Q7LDI5 Q96KR0 Q9H3D2 Q9H3D3 Q9H3P8 Q9NPH7 Q9P1B4 Q9P1B5 Q9P1B6 Q9P1B7 Q9UBV9 Q9UE10 Q9UP26 Q9UP27 Q9UP28 Q9UP74

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 10 CDD 2 CTD 1 ChEBI 5 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 100 EPD 1 Ensembl 11 EvolutionaryTrace 1 ExpressionAtlas 1 GO 70 Gene3D 3 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 17 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 9 OrthoDB 1 PANTHER 2 PDB 32 PDBsum 21 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 12 RNAct 1 Reactome 8 RefSeq 11 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9703973

Title: A second p53-related protein, p73L, with high homology to p73.

PubMed ID: 9703973

DOI: 10.1006/bbrc.1998.9013

PubMed ID: 9799841

Title: Cloning and chromosomal mapping of the human p53-related KET gene to chromosome 3q27 and its murine homolog Ket to mouse chromosome 16.

PubMed ID: 9799841

DOI: 10.1007/s003359900891

PubMed ID: 9774969

Title: p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities.

PubMed ID: 9774969

DOI: 10.1016/s1097-2765(00)80275-0

PubMed ID: 9662378

Title: Cloning and functional analysis of human p51, which structurally and functionally resembles p53.

PubMed ID: 9662378

DOI: 10.1038/nm0798-839

PubMed ID: 10485447

Title: Mutational analysis of the p63/p73L/p51/p40/CUSP/KET gene in human cancer cell lines using intronic primers.

PubMed ID: 10485447

PubMed ID: 10469295

Title: Characterization of an autoantigen associated with chronic ulcerative stomatitis: the CUSP autoantigen is a member of the p53 family.

PubMed ID: 10469295

DOI: 10.1046/j.1523-1747.1999.00651.x

PubMed ID: 10935472

Title: Mutation and expression of the p51 gene in human lung cancer.

PubMed ID: 10935472

DOI: 10.1038/sj.neo.7900008

PubMed ID: 11336476

Title: Transcriptional dysregulation of the p73L/p63/p51/p40/KET gene in human squamous cell carcinomas: expression of Delta Np73L, a novel dominant-negative isoform, and loss of expression of the potential tumour suppressor p51.

PubMed ID: 11336476

DOI: 10.1054/bjoc.2000.1735

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9662346

Title: A new human p53 homologue.

PubMed ID: 9662346

DOI: 10.1038/nm0798-747

PubMed ID: 11477076

Title: High thermostability and lack of cooperative DNA binding distinguish the p63 core domain from the homologous tumor suppressor p53.

PubMed ID: 11477076

DOI: 10.1074/jbc.m103801200

PubMed ID: 10373484

Title: p73 and p63 are homotetramers capable of weak heterotypic interactions with each other but not with p53.

PubMed ID: 10373484

DOI: 10.1074/jbc.274.26.18709

PubMed ID: 11248048

Title: p63 identifies keratinocyte stem cells.

PubMed ID: 11248048

DOI: 10.1073/pnas.061032098

PubMed ID: 11641404

Title: The p53 family member genes are involved in the Notch signal pathway.

PubMed ID: 11641404

DOI: 10.1074/jbc.m108080200

PubMed ID: 11925430

Title: Identification and characterization of HIPK2 interacting with p73 and modulating functions of the p53 family in vivo.

PubMed ID: 11925430

DOI: 10.1074/jbc.m200153200

PubMed ID: 12446779

Title: A C-terminal inhibitory domain controls the activity of p63 by an intramolecular mechanism.

PubMed ID: 12446779

DOI: 10.1128/mcb.22.24.8601-8611.2002

PubMed ID: 12446784

Title: Complex transcriptional effects of p63 isoforms: identification of novel activation and repression domains.

PubMed ID: 12446784

DOI: 10.1128/mcb.22.24.8659-8668.2002

PubMed ID: 12374749

Title: SSRP1 functions as a co-activator of the transcriptional activator p63.

PubMed ID: 12374749

DOI: 10.1093/emboj/cdf540

PubMed ID: 18806757

Title: WW domain-containing E3 ubiquitin protein ligase 1 targets p63 transcription factor for ubiquitin-mediated proteasomal degradation and regulates apoptosis.

PubMed ID: 18806757

DOI: 10.1038/cdd.2008.134

PubMed ID: 17846787

Title: SCC-112 gene is involved in tumor progression and promotes the cell proliferation in G2/M phase.

PubMed ID: 17846787

DOI: 10.1007/s00432-007-0306-x

PubMed ID: 20123734

Title: NIR, an inhibitor of histone acetyltransferases, regulates transcription factor TAp63 and is controlled by the cell cycle.

PubMed ID: 20123734

DOI: 10.1093/nar/gkq016

PubMed ID: 22197488

Title: Exome sequence identifies RIPK4 as the Bartsocas-Papas syndrome locus.

PubMed ID: 22197488

DOI: 10.1016/j.ajhg.2011.11.013

PubMed ID: 10535733

Title: Heterozygous germline mutations in the p53 homolog p63 are the cause of EEC syndrome.

PubMed ID: 10535733

DOI: 10.1016/s0092-8674(00)81646-3

PubMed ID: 10839977

Title: Split-hand/split-foot malformation is caused by mutations in the p63 gene on 3q27.

PubMed ID: 10839977

DOI: 10.1086/302972

PubMed ID: 11528512

Title: TP63 gene mutation in ADULT syndrome.

PubMed ID: 11528512

DOI: 10.1038/sj.ejhg.5200676

PubMed ID: 11159940

Title: Hay-Wells syndrome is caused by heterozygous missense mutations in the SAM domain of p63.

PubMed ID: 11159940

DOI: 10.1093/hmg/10.3.221

PubMed ID: 11462173

Title: p63 gene mutations in EEC syndrome, limb-mammary syndrome, and isolated split hand-split foot malformation suggest a genotype-phenotype correlation.

PubMed ID: 11462173

DOI: 10.1086/323123

PubMed ID: 11929852

Title: Gain-of-function mutation in ADULT syndrome reveals the presence of a second transactivation domain in p63.

PubMed ID: 11929852

DOI: 10.1093/hmg/11.7.799

PubMed ID: 12838557

Title: EEC syndrome type 3 with a heterozygous germline mutation in the P63 gene and B cell lymphoma.

PubMed ID: 12838557

DOI: 10.1002/ajmg.a.20064

PubMed ID: 12939657

Title: The Rapp-Hodgkin syndrome results from mutations of the TP63 gene.

PubMed ID: 12939657

DOI: 10.1038/sj.ejhg.5201004

PubMed ID: 12766194

Title: Heterozygous mutation in the SAM domain of p63 underlies Rapp-Hodgkin ectodermal dysplasia.

PubMed ID: 12766194

DOI: 10.1177/154405910308200606

PubMed ID: 15200513

Title: Molecular evidence that AEC syndrome and Rapp-Hodgkin syndrome are variable expression of a single genetic disorder.

PubMed ID: 15200513

DOI: 10.1111/j.0009-9163.2004.00278.x

PubMed ID: 16740912

Title: A mutation of the p63 gene in non-syndromic cleft lip.

PubMed ID: 16740912

DOI: 10.1136/jmg.2005.036442

PubMed ID: 30924587

Title: TP63-truncating variants cause isolated premature ovarian insufficiency.

PubMed ID: 30924587

DOI: 10.1002/humu.23744

PubMed ID: 32067224

Title: Novel phenotype of syndromic premature ovarian insufficiency associated with TP63 molecular defect.

PubMed ID: 32067224

DOI: 10.1111/cge.13725

PubMed ID: 35801529

Title: Dominant TP63 missense variants lead to constitutive activation and premature ovarian insufficiency.

PubMed ID: 35801529

DOI: 10.1002/humu.24432

PubMed ID: 36856110

Title: TP63 gain-of-function mutations cause premature ovarian insufficiency by inducing oocyte apoptosis.

PubMed ID: 36856110

DOI: 10.1172/jci162315

Sequence Information:

  • Length: 680
  • Mass: 76785
  • Checksum: F66ECD45E87D9799
  • Sequence:
    • MNFETSRCAT LQYCPDPYIQ RFVETPAHFS WKESYYRSTM SQSTQTNEFL SPEVFQHIWD 
FLEQPICSVQ PIDLNFVDEP SEDGATNKIE ISMDCIRMQD SDLSDPMWPQ YTNLGLLNSM 
DQQIQNGSSS TSPYNTDHAQ NSVTAPSPYA QPSSTFDALS PSPAIPSNTD YPGPHSFDVS 
FQQSSTAKSA TWTYSTELKK LYCQIAKTCP IQIKVMTPPP QGAVIRAMPV YKKAEHVTEV 
VKRCPNHELS REFNEGQIAP PSHLIRVEGN SHAQYVEDPI TGRQSVLVPY EPPQVGTEFT 
TVLYNFMCNS SCVGGMNRRP ILIIVTLETR DGQVLGRRCF EARICACPGR DRKADEDSIR 
KQQVSDSTKN GDGTKRPFRQ NTHGIQMTSI KKRRSPDDEL LYLPVRGRET YEMLLKIKES 
LELMQYLPQH TIETYRQQQQ QQHQHLLQKQ TSIQSPSSYG NSSPPLNKMN SMNKLPSVSQ 
LINPQQRNAL TPTTIPDGMG ANIPMMGTHM PMAGDMNGLS PTQALPPPLS MPSTSHCTPP 
PPYPTDCSIV SFLARLGCSS CLDYFTTQGL TTIYQIEHYS MDDLASLKIP EQFRHAIWKG 
ILDHRQLHEF SSPSHLLRTP SSASTVSVGS SETRGERVID AVRFTLRQTI SFPPRDEWND 
FNFDMDARRN KQQRIKEEGE

Genular Protein ID: 2420766524

Symbol: B7Z8X6_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z8X6

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 5 DNASU 1 EMBL 2 GO 9 Gene3D 2 GenomeRNAi 1 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 1 PRINTS 1 PROSITE 1 PeptideAtlas 1 Pfam 4 RefSeq 4 RuleBase 1 SAM 1 SUPFAM 2

Sequence Information:

  • Length: 369
  • Mass: 41549
  • Checksum: C81C1C2A3AE4CE51
  • Sequence:
    • MLYLENNAQT QFSEPQYTNL GLLNSMDQQI QNGSSSTSPY NTDHAQNSVT APSPYAQPSS 
TFDALSPSPA IPSNTDYPGP HSFDVSFQQS STAKSATWTY STELKKLYCQ IAKTCPIQIK 
VMTPPPQGAV IRAMPVYKKA EHVTEVVKRC PNHELSREFN EGQIAPPSHL IRVEGNSHAQ 
YVEDPITGRQ SVLVPYEPPQ VGTEFTTVLY NFMCNSSCVG GMNRRPILII VTLETRDGQV 
LGRRCFEARI CACPGRDRKA DEDSIRKQQV SDSTKNGDGT KRPFRQNTHG IQMTSIKKRR 
SPDDELLYLP VRGRETYEML LKIKESLELM QYLPQHTIET YRQQHEQAAF CEPAYQPSAA 
QRPHSYNHS

Genular Protein ID: 800655800

Symbol: A0A141PNN4_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A141PNN4

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 5 ChiTaRS 1 DNASU 1 EMBL 2 GO 9 Gene3D 2 GenomeRNAi 1 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 1 PRINTS 1 PROSITE 1 PeptideAtlas 1 Pfam 4 RefSeq 1 RuleBase 1 SAM 1 SUPFAM 2

Sequence Information:

  • Length: 327
  • Mass: 37114
  • Checksum: EE191C8F74C65DBC
  • Sequence:
    • MLYLENNAQT QFSEYSTELK KLYCQIAKTC PIQIKVMTPP PQGAVIRAMP VYKKAEHVTE 
VVKRCPNHEL SREFNEGQIA PPSHLIRVEG NSHAQYVEDP ITGRQSVLVP YEPPQVGTEF 
TTVLYNFMCN SSCVGGMNRR PILIIVTLET RDGQVLGRRC FEARICACPG RDRKADEDSI 
RKQQVSDSTK NGDAFRQNTH GIQMTSIKKR RSPDDELLYL PVRGRETYEM LLKIKESLEL 
MQYLPQHTIE TYRQQQQQQH QHLLQKQTSI QSPSSYGNSS PPLNKMNSMN KLPSVSQLIN 
PQQRNALTPT TIPDGMGANR SGKSENP

Genular Protein ID: 3014553011

Symbol: A0A0S2Z4N6_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0S2Z4N6

Database IDs:

ARBA 7 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChEBI 5 ChiTaRS 1 DNASU 1 EMBL 2 ExpressionAtlas 1 GO 7 Gene3D 3 GenomeRNAi 1 IntAct 1 InterPro 9 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 1 PRINTS 1 PROSITE 1 Pfam 3 RefSeq 1 RuleBase 1 SAM 1 SMART 2 SMR 1 SUPFAM 3 VEuPathDB 1

Citations:

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

  • Length: 676
  • Mass: 76317
  • Checksum: EB0E2C9E93C6D34A
  • Sequence:
    • MNFETSRCAT LQYCPDPYIQ RFVETPAHFS WKESYYRSTM SQSTQTNEFL SPEVFQHIWD 
FLEQPICSVQ PIDLNFVDEP SEDGATNKIE ISMDCIRMQD SDLSDPMWPQ YTNLGLLNSM 
DQQIQNGSSS TSPYNTDHAQ NSVTAPSPYA QPSSTFDALS PSPAIPSNTD YPGPHSFDVS 
FQQSSTAKSA TWTYSTELKK LYCQIAKTCP IQIKVMTPPP QGAVIRAMPV YKKAEHVTEV 
VKRCPNHELS REFNEGQIAP PSHLIRVEGN SHAQYVEDPI TGRQSVLVPY EPPQVGTEFT 
TVLYNFMCNS SCVGGMNRRP ILIIVTLETR DGQVLGRRCF EARICACPGR DRKADEDSIR 
KQQVSDSTKN GDAFRQNTHG IQMTSIKKRR SPDDELLYLP VRGRETYEML LKIKESLELM 
QYLPQHTIET YRQQQQQQHQ HLLQKQTSIQ SPSSYGNSSP PLNKMNSMNK LPSVSQLINP 
QQRNALTPTT IPDGMGANIP MMGTHMPMAG DMNGLSPTQA LPPPLSMPST SHCTPPPPYP 
TDCSIVSFLA RLGCSSCLDY FTTQGLTTIY QIEHYSMDDL ASLKIPEQFR HAIWKGILDH 
RQLHEFSSPS HLLRTPSSAS TVSVGSSETR GERVIDAVRF TLRQTISFPP RDEWNDFNFD 
MDARRNKQQR IKEEGE

Genular Protein ID: 1792862600

Symbol: A0A141PNN3_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A141PNN3

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 5 ChiTaRS 1 DNASU 1 EMBL 2 GO 9 Gene3D 2 GenomeRNAi 1 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 1 PRINTS 1 PROSITE 1 PeptideAtlas 1 Pfam 4 RefSeq 1 RuleBase 1 SAM 1 SMR 1 SUPFAM 2

Sequence Information:

  • Length: 412
  • Mass: 46121
  • Checksum: 6825355B5928466B
  • Sequence:
    • MLYLENNAQT QFSEPQYTNL GLLNSMDQQI QNGSSSTSPY NTDHAQNSVT APSPYAQPSS 
TFDALSPSPA IPSNTDYPGP HSFDVSFQQS STAKSATWTY STELKKLYCQ IAKTCPIQIK 
VMTPPPQGAV IRAMPVYKKA EHVTEVVKRC PNHELSREFN EGQIAPPSHL IRVEGNSHAQ 
YVEDPITGRQ SVLVPYEPPQ VGTEFTTVLY NFMCNSSCVG GMNRRPILII VTLETRDGQV 
LGRRCFEARI CACPGRDRKA DEDSIRKQQV SDSTKNGDAF RQNTHGIQMT SIKKRRSPDD 
ELLYLPVRGR ETYEMLLKIK ESLELMQYLP QHTIETYRQQ QQQQHQHLLQ KQTSIQSPSS 
YGNSSPPLNK MNSMNKLPSV SQLINPQQRN ALTPTTIPDG MGANRSGKSE NP

Genular Protein ID: 2096181564

Symbol: C9D7D0_HUMAN

Name: N/A

UniProtKB Accession Codes:

C9D7D0

Database IDs:

ARBA 6 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 5 ChiTaRS 1 DNASU 1 EMBL 4 ExpressionAtlas 1 GO 9 Gene3D 2 GenomeRNAi 1 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 1 PRINTS 1 PROSITE 1 Pfam 4 RefSeq 6 RuleBase 1 SAM 1 SMR 1 SUPFAM 2 VEuPathDB 1

Citations:

PubMed ID: 19700772

Title: Identification and functional characterization of two new transcriptional variants of the human p63 gene.

PubMed ID: 19700772

DOI: 10.1093/nar/gkp674

Sequence Information:

  • Length: 416
  • Mass: 46589
  • Checksum: A5974A14B25E3118
  • Sequence:
    • MLYLENNAQT QFSEPQYTNL GLLNSMDQQI QNGSSSTSPY NTDHAQNSVT APSPYAQPSS 
TFDALSPSPA IPSNTDYPGP HSFDVSFQQS STAKSATWTY STELKKLYCQ IAKTCPIQIK 
VMTPPPQGAV IRAMPVYKKA EHVTEVVKRC PNHELSREFN EGQIAPPSHL IRVEGNSHAQ 
YVEDPITGRQ SVLVPYEPPQ VGTEFTTVLY NFMCNSSCVG GMNRRPILII VTLETRDGQV 
LGRRCFEARI CACPGRDRKA DEDSIRKQQV SDSTKNGDGT KRPFRQNTHG IQMTSIKKRR 
SPDDELLYLP VRGRETYEML LKIKESLELM QYLPQHTIET YRQQQQQQHQ HLLQKQTSIQ 
SPSSYGNSSP PLNKMNSMNK LPSVSQLINP QQRNALTPTT IPDGMGANRS GKSENP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.