Details for: TP63

Gene ID: 8626

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: TP63

Ensembl ID: ENSG00000073282

Description: tumor protein p63

Cell Significance Landscape

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • parietal epithelial cell CL1000452
    CSI 5.55
    rCSI 14.84%
    PRS 95.78
  • conjunctival epithelial cell CL1000432
    CSI 5.16
    rCSI 7.88%
    PRS 96.73
  • secretory cell CL0000151
    CSI 3.49
    rCSI 3.64%
    PRS 97.07
  • respiratory hillock cell CL4030023
    CSI 3.15
    rCSI 5.62%
    PRS 98.41
  • vascular leptomeningeal cell CL4023051
    CSI 3.08
    rCSI 5.41%
    PRS 95.97
  • respiratory basal cell CL0002633
    CSI 3.07
    rCSI 3.18%
    PRS 97.94
  • keratinocyte CL0000312
    CSI 3
    rCSI 2.51%
    PRS 96.71
  • adipocyte CL0000136
    CSI 2.96
    rCSI 3.8%
    PRS 93.81
  • placental villous trophoblast CL2000060
    CSI 2.96
    rCSI 4.57%
    PRS 96.59
  • respiratory suprabasal cell CL4033048
    CSI 2.81
    rCSI 3.61%
    PRS 97.97
  • fast muscle cell CL0000190
    CSI 2.76
    rCSI 10.77%
    PRS 91.38
  • epithelial cell CL0000066
    CSI 2.55
    rCSI 3.91%
    PRS 90.49
  • basal cell CL0000646
    CSI 2.52
    rCSI 3.37%
    PRS 96.11
  • diffuse bipolar 6 cell CL4033032
    CSI 2.23
    rCSI 11.72%
    PRS 91.35
  • myoepithelial cell CL0000185
    CSI 2.22
    rCSI 5.63%
    PRS 98.36
  • chandelier pvalb GABAergic cortical interneuron CL4023036
    CSI 2.16
    rCSI 6.77%
    PRS 93.79
  • epicardial adipocyte CL1000309
    CSI 1.84
    rCSI 5.97%
    PRS 96
  • corneal epithelial cell CL0000575
    CSI 1.76
    rCSI 5.04%
    PRS 97.39
  • cell of skeletal muscle CL0000188
    CSI 0.89
    rCSI 9.65%
    PRS 93.96
  • basal cell of epithelium of trachea CL1000348
    CSI 0.72
    rCSI 5.07%
    PRS 97.31
  • hair follicular keratinocyte CL2000092
    CSI 0.39
    rCSI 6.73%
    PRS 96.84
  • indirect pathway medium spiny neuron CL4023029
    CSI 0.31
    rCSI 7.58%
    PRS 90.11
  • direct pathway medium spiny neuron CL4023026
    CSI 0.29
    rCSI 6.95%
    PRS 90.37

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

Loading network (please wait)...

Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [TP63](/details-gene/8626) (Tumor protein p63) is a protein-coding gene located on chromosome 3q28. As a member of the p53 family of transcription factors, it plays a critical and complex role in development, cell differentiation, and apoptosis ([Link](https://doi.org/10.1016/s1097-2765(00)80275-0)). Unlike its well-known relative p53, [TP63](/details-gene/8626) is essential for the development and maintenance of stratified epithelial tissues, including the epidermis, hair follicles, and various glands. **Overall**, expression data reveals that [TP63](/details-gene/8626) is a highly significant marker gene for a wide range of epithelial cell types, particularly those with progenitor or basal characteristics, such as [keratinocyte](/details-cell/CL0000312)s and [respiratory basal cell](/details-cell/CL0002633)s. Mutations in this gene are associated with several developmental syndromes characterized by ectodermal dysplasia, such as ankyloblepharon-ectodermal defects-cleft lip/palate (AEC) syndrome ([106260](https://omim.org/entry/106260)) and ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3) ([129400](https://omim.org/entry/129400)). ## Cellular Roles and Expression Landscape The expression profile of [TP63](/details-gene/8626) strongly indicates its central function in establishing and maintaining epithelial cell identity. **Overall**, the gene exhibits its highest significance scores in diverse epithelial populations. It is a top marker for [parietal epithelial cell](/details-cell/CL1000452) (CSI: 5.55), [conjunctival epithelial cell](/details-cell/CL1000432) (CSI: 5.16), and [secretory cell](/details-cell/CL0000151) (CSI: 3.49). Its prominent role in progenitor and stem cell compartments is highlighted by its high significance in [respiratory basal cell](/details-cell/CL0002633) (CSI: 3.07) and [keratinocyte](/details-cell/CL0000312) (CSI: 3.00), which is consistent with research identifying p63 as a marker for keratinocyte stem cells ([Link](https://doi.org/10.1073/pnas.061032098)). The gene's importance extends to other specialized epithelial-like cells, including [placental villous trophoblast](/details-cell/CL2000060) (CSI: 2.96) and [myoepithelial cell](/details-cell/CL0000185) (CSI: 2.22). This expression pattern suggests that [TP63](/details-gene/8626) is a master regulator orchestrating the transcriptional programs necessary for the development, stratification, and homeostasis of multiple epithelial tissues throughout the body. ## Pathways and Molecular Function Functionally, [TP63](/details-gene/8626) operates primarily as a sequence-specific DNA-binding transcription factor. Its molecular function annotations confirm its roles in [Dna-binding transcription factor activity, rna polymerase ii-specific](/details-go/GO:0000981) and [Chromatin binding](/details-go/GO:0003682). The biological processes it governs are extensive and align with its cellular expression profile. [TP63](/details-gene/8626) is heavily involved in epithelial development, as shown by its annotation to processes such as [Keratinocyte differentiation](/details-go/GO:0030216), [Hair follicle morphogenesis](/details-go/GO:0031069), [Skin morphogenesis](/details-go/GO:0043589), and [Establishment of skin barrier](/details-go/GO:0061436). Reactome pathway analysis further clarifies its mechanistic roles. The gene is a central component of the [Transcriptional regulation by tp53](/details-reactome/R-HSA-3700989) pathway, underscoring its homology and shared regulatory network with p53. Its involvement in [Developmental biology](/details-reactome/R-HSA-1266738) is explicitly detailed in pathways like [Differentiation of keratinocytes in interfollicular epidermis in mammalian skin](/details-reactome/R-HSA-9725554). Furthermore, similar to p53, [TP63](/details-gene/8626) is implicated in cell fate decisions, participating in both [Apoptosis](/details-reactome/R-HSA-109581) and the [Notch signaling pathway](/details-go/GO:0007219) ([Link](https://doi.org/10.1074/jbc.m108080200)), which is critical for cell-cell communication during development. ## Research Directions The dual role of [TP63](/details-gene/8626) in normal development and its dysregulation in disease presents several avenues for future research. While essential for epithelial homeostasis, its overexpression is a hallmark of squamous cell carcinomas, suggesting a context-dependent switch from a developmental regulator to a lineage-survival oncogene. **Proposed Hypotheses:** 1. **Hypothesis:** The balance of different [TP63](/details-gene/8626) isoforms dictates the switch between progenitor cell self-renewal and terminal differentiation in stratified epithelia. A shift towards expression of the truncated ΔN-isoforms in response to cellular stress or oncogenic signals promotes a persistent basal-like state, contributing to the initiation of squamous cell carcinoma. 2. **Hypothesis:** During craniofacial development, [TP63](/details-gene/8626) coordinates epithelial-mesenchymal interactions by regulating the expression of key signaling molecules in the surface ectoderm. Pathogenic mutations associated with clefting syndromes disrupt this signaling, leading to failed fusion of craniofacial processes. **Experimental Approach:** To test the first hypothesis regarding isoform switching in cancer, a compelling experiment would involve the use of patient-derived organoids from skin squamous cell carcinoma. Using isoform-specific CRISPR-Cas9 editing, one could selectively deplete the full-length (TAp63) versus the truncated (ΔNp63) isoforms. The resulting organoids would be analyzed using single-cell RNA sequencing to assess changes in cellular heterogeneity, differentiation trajectories (e.g., expression of keratinocyte differentiation markers like KRT1/10), and proliferation rates. This approach would directly test the functional contribution of each isoform class to maintaining the cancer stem cell population. **Therapeutic Potential:** As a nuclear transcription factor, [TP63](/details-gene/8626) represents a challenging therapeutic target for direct inhibition with small molecules. However, its crucial role in sustaining certain cancers, particularly squamous cell carcinomas, makes it highly attractive. The therapeutic strategy would focus on **inhibition**. Given its high specificity to epithelial lineages, targeting [TP63](/details-gene/8626) could offer a therapeutic window with fewer off-target effects compared to broadly expressed oncogenes. Future strategies may involve developing proteolysis-targeting chimeras (PROTACs) to induce its degradation or targeting critical protein-protein interactions required for its transcriptional activity, thereby disrupting the survival programs it maintains in cancer cells.

Genular Protein ID: 3965160155

Symbol: P63_HUMAN

Name: Tumor protein 63

UniProtKB Accession Codes:

Q9H3D4 O75080 O75195 O75922 O76078 Q6VEG2 Q6VEG3 Q6VEG4 Q6VFJ1 Q6VFJ2 Q6VFJ3 Q6VH20 Q7LDI3 Q7LDI4 Q7LDI5 Q96KR0 Q9H3D2 Q9H3D3 Q9H3P8 Q9NPH7 Q9P1B4 Q9P1B5 Q9P1B6 Q9P1B7 Q9UBV9 Q9UE10 Q9UP26 Q9UP27 Q9UP28 Q9UP74

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 10 CDD 2 CTD 1 ChEBI 5 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 170 Ensembl 11 EvolutionaryTrace 1 ExpressionAtlas 1 GO 71 Gene3D 3 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 17 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 9 OrthoDB 1 PANTHER 2 PDB 24 PDBsum 24 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 12 RNAct 1 Reactome 9 RefSeq 11 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9703973

Title: A second p53-related protein, p73L, with high homology to p73.

PubMed ID: 9703973

DOI: 10.1006/bbrc.1998.9013

PubMed ID: 9799841

Title: Cloning and chromosomal mapping of the human p53-related KET gene to chromosome 3q27 and its murine homolog Ket to mouse chromosome 16.

PubMed ID: 9799841

DOI: 10.1007/s003359900891

PubMed ID: 9774969

Title: p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities.

PubMed ID: 9774969

DOI: 10.1016/s1097-2765(00)80275-0

PubMed ID: 9662378

Title: Cloning and functional analysis of human p51, which structurally and functionally resembles p53.

PubMed ID: 9662378

DOI: 10.1038/nm0798-839

PubMed ID: 10485447

Title: Mutational analysis of the p63/p73L/p51/p40/CUSP/KET gene in human cancer cell lines using intronic primers.

PubMed ID: 10485447

PubMed ID: 10469295

Title: Characterization of an autoantigen associated with chronic ulcerative stomatitis: the CUSP autoantigen is a member of the p53 family.

PubMed ID: 10469295

DOI: 10.1046/j.1523-1747.1999.00651.x

PubMed ID: 10935472

Title: Mutation and expression of the p51 gene in human lung cancer.

PubMed ID: 10935472

DOI: 10.1038/sj.neo.7900008

PubMed ID: 11336476

Title: Transcriptional dysregulation of the p73L/p63/p51/p40/KET gene in human squamous cell carcinomas: expression of Delta Np73L, a novel dominant-negative isoform, and loss of expression of the potential tumour suppressor p51.

PubMed ID: 11336476

DOI: 10.1054/bjoc.2000.1735

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9662346

Title: A new human p53 homologue.

PubMed ID: 9662346

DOI: 10.1038/nm0798-747

PubMed ID: 11477076

Title: High thermostability and lack of cooperative DNA binding distinguish the p63 core domain from the homologous tumor suppressor p53.

PubMed ID: 11477076

DOI: 10.1074/jbc.m103801200

PubMed ID: 10373484

Title: p73 and p63 are homotetramers capable of weak heterotypic interactions with each other but not with p53.

PubMed ID: 10373484

DOI: 10.1074/jbc.274.26.18709

PubMed ID: 11248048

Title: p63 identifies keratinocyte stem cells.

PubMed ID: 11248048

DOI: 10.1073/pnas.061032098

PubMed ID: 11641404

Title: The p53 family member genes are involved in the Notch signal pathway.

PubMed ID: 11641404

DOI: 10.1074/jbc.m108080200

PubMed ID: 11925430

Title: Identification and characterization of HIPK2 interacting with p73 and modulating functions of the p53 family in vivo.

PubMed ID: 11925430

DOI: 10.1074/jbc.m200153200

PubMed ID: 12446779

Title: A C-terminal inhibitory domain controls the activity of p63 by an intramolecular mechanism.

PubMed ID: 12446779

DOI: 10.1128/mcb.22.24.8601-8611.2002

PubMed ID: 12446784

Title: Complex transcriptional effects of p63 isoforms: identification of novel activation and repression domains.

PubMed ID: 12446784

DOI: 10.1128/mcb.22.24.8659-8668.2002

PubMed ID: 12374749

Title: SSRP1 functions as a co-activator of the transcriptional activator p63.

PubMed ID: 12374749

DOI: 10.1093/emboj/cdf540

PubMed ID: 18806757

Title: WW domain-containing E3 ubiquitin protein ligase 1 targets p63 transcription factor for ubiquitin-mediated proteasomal degradation and regulates apoptosis.

PubMed ID: 18806757

DOI: 10.1038/cdd.2008.134

PubMed ID: 17846787

Title: SCC-112 gene is involved in tumor progression and promotes the cell proliferation in G2/M phase.

PubMed ID: 17846787

DOI: 10.1007/s00432-007-0306-x

PubMed ID: 20123734

Title: NIR, an inhibitor of histone acetyltransferases, regulates transcription factor TAp63 and is controlled by the cell cycle.

PubMed ID: 20123734

DOI: 10.1093/nar/gkq016

PubMed ID: 22197488

Title: Exome sequence identifies RIPK4 as the Bartsocas-Papas syndrome locus.

PubMed ID: 22197488

DOI: 10.1016/j.ajhg.2011.11.013

PubMed ID: 10535733

Title: Heterozygous germline mutations in the p53 homolog p63 are the cause of EEC syndrome.

PubMed ID: 10535733

DOI: 10.1016/s0092-8674(00)81646-3

PubMed ID: 10839977

Title: Split-hand/split-foot malformation is caused by mutations in the p63 gene on 3q27.

PubMed ID: 10839977

DOI: 10.1086/302972

PubMed ID: 11528512

Title: TP63 gene mutation in ADULT syndrome.

PubMed ID: 11528512

DOI: 10.1038/sj.ejhg.5200676

PubMed ID: 11159940

Title: Hay-Wells syndrome is caused by heterozygous missense mutations in the SAM domain of p63.

PubMed ID: 11159940

DOI: 10.1093/hmg/10.3.221

PubMed ID: 11462173

Title: p63 gene mutations in EEC syndrome, limb-mammary syndrome, and isolated split hand-split foot malformation suggest a genotype-phenotype correlation.

PubMed ID: 11462173

DOI: 10.1086/323123

PubMed ID: 11929852

Title: Gain-of-function mutation in ADULT syndrome reveals the presence of a second transactivation domain in p63.

PubMed ID: 11929852

DOI: 10.1093/hmg/11.7.799

PubMed ID: 12838557

Title: EEC syndrome type 3 with a heterozygous germline mutation in the P63 gene and B cell lymphoma.

PubMed ID: 12838557

DOI: 10.1002/ajmg.a.20064

PubMed ID: 12939657

Title: The Rapp-Hodgkin syndrome results from mutations of the TP63 gene.

PubMed ID: 12939657

DOI: 10.1038/sj.ejhg.5201004

PubMed ID: 12766194

Title: Heterozygous mutation in the SAM domain of p63 underlies Rapp-Hodgkin ectodermal dysplasia.

PubMed ID: 12766194

DOI: 10.1177/154405910308200606

PubMed ID: 15200513

Title: Molecular evidence that AEC syndrome and Rapp-Hodgkin syndrome are variable expression of a single genetic disorder.

PubMed ID: 15200513

DOI: 10.1111/j.0009-9163.2004.00278.x

PubMed ID: 16740912

Title: A mutation of the p63 gene in non-syndromic cleft lip.

PubMed ID: 16740912

DOI: 10.1136/jmg.2005.036442

PubMed ID: 30924587

Title: TP63-truncating variants cause isolated premature ovarian insufficiency.

PubMed ID: 30924587

DOI: 10.1002/humu.23744

PubMed ID: 32067224

Title: Novel phenotype of syndromic premature ovarian insufficiency associated with TP63 molecular defect.

PubMed ID: 32067224

DOI: 10.1111/cge.13725

PubMed ID: 35801529

Title: Dominant TP63 missense variants lead to constitutive activation and premature ovarian insufficiency.

PubMed ID: 35801529

DOI: 10.1002/humu.24432

PubMed ID: 36856110

Title: TP63 gain-of-function mutations cause premature ovarian insufficiency by inducing oocyte apoptosis.

PubMed ID: 36856110

DOI: 10.1172/jci162315

Sequence Information:

  • Length: 680
  • Mass: 76785
  • Checksum: F66ECD45E87D9799
  • Sequence:
    • MNFETSRCAT LQYCPDPYIQ RFVETPAHFS WKESYYRSTM SQSTQTNEFL SPEVFQHIWD 
FLEQPICSVQ PIDLNFVDEP SEDGATNKIE ISMDCIRMQD SDLSDPMWPQ YTNLGLLNSM 
DQQIQNGSSS TSPYNTDHAQ NSVTAPSPYA QPSSTFDALS PSPAIPSNTD YPGPHSFDVS 
FQQSSTAKSA TWTYSTELKK LYCQIAKTCP IQIKVMTPPP QGAVIRAMPV YKKAEHVTEV 
VKRCPNHELS REFNEGQIAP PSHLIRVEGN SHAQYVEDPI TGRQSVLVPY EPPQVGTEFT 
TVLYNFMCNS SCVGGMNRRP ILIIVTLETR DGQVLGRRCF EARICACPGR DRKADEDSIR 
KQQVSDSTKN GDGTKRPFRQ NTHGIQMTSI KKRRSPDDEL LYLPVRGRET YEMLLKIKES 
LELMQYLPQH TIETYRQQQQ QQHQHLLQKQ TSIQSPSSYG NSSPPLNKMN SMNKLPSVSQ 
LINPQQRNAL TPTTIPDGMG ANIPMMGTHM PMAGDMNGLS PTQALPPPLS MPSTSHCTPP 
PPYPTDCSIV SFLARLGCSS CLDYFTTQGL TTIYQIEHYS MDDLASLKIP EQFRHAIWKG 
ILDHRQLHEF SSPSHLLRTP SSASTVSVGS SETRGERVID AVRFTLRQTI SFPPRDEWND 
FNFDMDARRN KQQRIKEEGE

Genular Protein ID: 3014553011

Symbol: A0A0S2Z4N6_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0S2Z4N6

Database IDs:

ARBA 7 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChEBI 5 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 ExpressionAtlas 1 GO 7 Gene3D 3 IntAct 1 InterPro 9 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 3 PRINTS 1 PROSITE 1 Pfam 3 RefSeq 1 RuleBase 1 SAM 1 SMART 2 SMR 1 SUPFAM 3 VEuPathDB 1

Citations:

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

  • Length: 676
  • Mass: 76317
  • Checksum: EB0E2C9E93C6D34A
  • Sequence:
    • MNFETSRCAT LQYCPDPYIQ RFVETPAHFS WKESYYRSTM SQSTQTNEFL SPEVFQHIWD 
FLEQPICSVQ PIDLNFVDEP SEDGATNKIE ISMDCIRMQD SDLSDPMWPQ YTNLGLLNSM 
DQQIQNGSSS TSPYNTDHAQ NSVTAPSPYA QPSSTFDALS PSPAIPSNTD YPGPHSFDVS 
FQQSSTAKSA TWTYSTELKK LYCQIAKTCP IQIKVMTPPP QGAVIRAMPV YKKAEHVTEV 
VKRCPNHELS REFNEGQIAP PSHLIRVEGN SHAQYVEDPI TGRQSVLVPY EPPQVGTEFT 
TVLYNFMCNS SCVGGMNRRP ILIIVTLETR DGQVLGRRCF EARICACPGR DRKADEDSIR 
KQQVSDSTKN GDAFRQNTHG IQMTSIKKRR SPDDELLYLP VRGRETYEML LKIKESLELM 
QYLPQHTIET YRQQQQQQHQ HLLQKQTSIQ SPSSYGNSSP PLNKMNSMNK LPSVSQLINP 
QQRNALTPTT IPDGMGANIP MMGTHMPMAG DMNGLSPTQA LPPPLSMPST SHCTPPPPYP 
TDCSIVSFLA RLGCSSCLDY FTTQGLTTIY QIEHYSMDDL ASLKIPEQFR HAIWKGILDH 
RQLHEFSSPS HLLRTPSSAS TVSVGSSETR GERVIDAVRF TLRQTISFPP RDEWNDFNFD 
MDARRNKQQR IKEEGE

Genular Protein ID: 2096181564

Symbol: C9D7D0_HUMAN

Name: N/A

UniProtKB Accession Codes:

C9D7D0

Database IDs:

ARBA 6 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 5 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 ExpressionAtlas 1 GO 8 Gene3D 2 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 3 PRINTS 1 PROSITE 1 Pfam 4 RefSeq 6 RuleBase 1 SAM 1 SMR 1 SUPFAM 2 VEuPathDB 1

Citations:

PubMed ID: 19700772

Title: Identification and functional characterization of two new transcriptional variants of the human p63 gene.

PubMed ID: 19700772

DOI: 10.1093/nar/gkp674

Sequence Information:

  • Length: 416
  • Mass: 46589
  • Checksum: A5974A14B25E3118
  • Sequence:
    • MLYLENNAQT QFSEPQYTNL GLLNSMDQQI QNGSSSTSPY NTDHAQNSVT APSPYAQPSS 
TFDALSPSPA IPSNTDYPGP HSFDVSFQQS STAKSATWTY STELKKLYCQ IAKTCPIQIK 
VMTPPPQGAV IRAMPVYKKA EHVTEVVKRC PNHELSREFN EGQIAPPSHL IRVEGNSHAQ 
YVEDPITGRQ SVLVPYEPPQ VGTEFTTVLY NFMCNSSCVG GMNRRPILII VTLETRDGQV 
LGRRCFEARI CACPGRDRKA DEDSIRKQQV SDSTKNGDGT KRPFRQNTHG IQMTSIKKRR 
SPDDELLYLP VRGRETYEML LKIKESLELM QYLPQHTIET YRQQQQQQHQ HLLQKQTSIQ 
SPSSYGNSSP PLNKMNSMNK LPSVSQLINP QQRNALTPTT IPDGMGANRS GKSENP

Genular Protein ID: 1792862600

Symbol: A0A141PNN3_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A141PNN3

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 5 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 8 Gene3D 2 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 3 PRINTS 1 PROSITE 1 PeptideAtlas 1 Pfam 4 RefSeq 1 RuleBase 1 SAM 1 SMR 1 SUPFAM 2

Sequence Information:

  • Length: 412
  • Mass: 46121
  • Checksum: 6825355B5928466B
  • Sequence:
    • MLYLENNAQT QFSEPQYTNL GLLNSMDQQI QNGSSSTSPY NTDHAQNSVT APSPYAQPSS 
TFDALSPSPA IPSNTDYPGP HSFDVSFQQS STAKSATWTY STELKKLYCQ IAKTCPIQIK 
VMTPPPQGAV IRAMPVYKKA EHVTEVVKRC PNHELSREFN EGQIAPPSHL IRVEGNSHAQ 
YVEDPITGRQ SVLVPYEPPQ VGTEFTTVLY NFMCNSSCVG GMNRRPILII VTLETRDGQV 
LGRRCFEARI CACPGRDRKA DEDSIRKQQV SDSTKNGDAF RQNTHGIQMT SIKKRRSPDD 
ELLYLPVRGR ETYEMLLKIK ESLELMQYLP QHTIETYRQQ QQQQHQHLLQ KQTSIQSPSS 
YGNSSPPLNK MNSMNKLPSV SQLINPQQRN ALTPTTIPDG MGANRSGKSE NP

Genular Protein ID: 2420766524

Symbol: B7Z8X6_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z8X6

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 5 DNASU 1 DisGeNET 1 EMBL 2 GO 8 Gene3D 2 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 3 PRINTS 1 PROSITE 1 PeptideAtlas 1 Pfam 4 RefSeq 4 RuleBase 1 SAM 1 SUPFAM 2

Sequence Information:

  • Length: 369
  • Mass: 41549
  • Checksum: C81C1C2A3AE4CE51
  • Sequence:
    • MLYLENNAQT QFSEPQYTNL GLLNSMDQQI QNGSSSTSPY NTDHAQNSVT APSPYAQPSS 
TFDALSPSPA IPSNTDYPGP HSFDVSFQQS STAKSATWTY STELKKLYCQ IAKTCPIQIK 
VMTPPPQGAV IRAMPVYKKA EHVTEVVKRC PNHELSREFN EGQIAPPSHL IRVEGNSHAQ 
YVEDPITGRQ SVLVPYEPPQ VGTEFTTVLY NFMCNSSCVG GMNRRPILII VTLETRDGQV 
LGRRCFEARI CACPGRDRKA DEDSIRKQQV SDSTKNGDGT KRPFRQNTHG IQMTSIKKRR 
SPDDELLYLP VRGRETYEML LKIKESLELM QYLPQHTIET YRQQHEQAAF CEPAYQPSAA 
QRPHSYNHS

Genular Protein ID: 800655800

Symbol: A0A141PNN4_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A141PNN4

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 5 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 8 Gene3D 2 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 2 PRINTS 1 PROSITE 1 PeptideAtlas 1 Pfam 4 RefSeq 1 RuleBase 1 SAM 1 SUPFAM 2

Sequence Information:

  • Length: 327
  • Mass: 37114
  • Checksum: EE191C8F74C65DBC
  • Sequence:
    • MLYLENNAQT QFSEYSTELK KLYCQIAKTC PIQIKVMTPP PQGAVIRAMP VYKKAEHVTE 
VVKRCPNHEL SREFNEGQIA PPSHLIRVEG NSHAQYVEDP ITGRQSVLVP YEPPQVGTEF 
TTVLYNFMCN SSCVGGMNRR PILIIVTLET RDGQVLGRRC FEARICACPG RDRKADEDSI 
RKQQVSDSTK NGDAFRQNTH GIQMTSIKKR RSPDDELLYL PVRGRETYEM LLKIKESLEL 
MQYLPQHTIE TYRQQQQQQH QHLLQKQTSI QSPSSYGNSS PPLNKMNSMN KLPSVSQLIN 
PQQRNALTPT TIPDGMGANR SGKSENP