Details for: CL0001082

Cell ID: CL0001082

Cell Name: immature innate lymphoid cell

Description: An innate lyphoid cell with an immature phenotype.

Synonyms: immature ILC

Genes (max top 100)

(Fold Change: Indicates the ratio of the CSI Threshold for immature innate lymphoid cell to Cell Significance Index of immature innate lymphoid cell in specific gene. A fold change greater than 1 suggests significant gene expression.)

  • Gene Symbol: A1BG (ENSG00000121410)
    Fold Change: N/A
    Ensembl ID: ENSG00000121410
  • Gene Symbol: A2M (ENSG00000175899)
    Fold Change: N/A
    Ensembl ID: ENSG00000175899
  • Gene Symbol: A2MP1 (ENSG00000291190)
    Fold Change: N/A
    Ensembl ID: ENSG00000291190
  • Gene Symbol: NAT1 (ENSG00000171428)
    Fold Change: N/A
    Ensembl ID: ENSG00000171428
  • Gene Symbol: NAT2 (ENSG00000156006)
    Fold Change: N/A
    Ensembl ID: ENSG00000156006
  • Gene Symbol: NATP (N/A)
    Fold Change: N/A
    Ensembl ID: N/A
  • Gene Symbol: SERPINA3 (ENSG00000196136)
    Fold Change: N/A
    Ensembl ID: ENSG00000196136
  • Gene Symbol: AADAC (ENSG00000114771)
    Fold Change: N/A
    Ensembl ID: ENSG00000114771
  • Gene Symbol: AAMP (ENSG00000127837)
    Fold Change: N/A
    Ensembl ID: ENSG00000127837
  • Gene Symbol: AANAT (ENSG00000129673)
    Fold Change: N/A
    Ensembl ID: ENSG00000129673
  • Gene Symbol: AARS1 (ENSG00000090861)
    Fold Change: N/A
    Ensembl ID: ENSG00000090861
  • Gene Symbol: AAVS1 (N/A)
    Fold Change: N/A
    Ensembl ID: N/A
  • Gene Symbol: ABAT (ENSG00000183044)
    Fold Change: N/A
    Ensembl ID: ENSG00000183044
  • Gene Symbol: ABCA1 (ENSG00000165029)
    Fold Change: N/A
    Ensembl ID: ENSG00000165029
  • Gene Symbol: ABCA2 (ENSG00000107331)
    Fold Change: N/A
    Ensembl ID: ENSG00000107331
  • Gene Symbol: ABCA3 (ENSG00000167972)
    Fold Change: N/A
    Ensembl ID: ENSG00000167972
  • Gene Symbol: ABCB7 (ENSG00000131269)
    Fold Change: N/A
    Ensembl ID: ENSG00000131269
  • Gene Symbol: ABCF1 (ENSG00000204574)
    Fold Change: N/A
    Ensembl ID: ENSG00000204574
  • Gene Symbol: ABCA4 (ENSG00000198691)
    Fold Change: N/A
    Ensembl ID: ENSG00000198691
  • Gene Symbol: ABL1 (ENSG00000097007)
    Fold Change: N/A
    Ensembl ID: ENSG00000097007
  • Gene Symbol: AOC1 (ENSG00000002726)
    Fold Change: N/A
    Ensembl ID: ENSG00000002726
  • Gene Symbol: ABL2 (ENSG00000143322)
    Fold Change: N/A
    Ensembl ID: ENSG00000143322
  • Gene Symbol: ABO (ENSG00000175164)
    Fold Change: N/A
    Ensembl ID: ENSG00000175164
  • Gene Symbol: ABR (ENSG00000159842)
    Fold Change: N/A
    Ensembl ID: ENSG00000159842
  • Gene Symbol: ACAA1 (ENSG00000060971)
    Fold Change: N/A
    Ensembl ID: ENSG00000060971
  • Gene Symbol: ACACA (ENSG00000278540)
    Fold Change: N/A
    Ensembl ID: ENSG00000278540
  • Gene Symbol: ACACB (ENSG00000076555)
    Fold Change: N/A
    Ensembl ID: ENSG00000076555
  • Gene Symbol: ACADL (ENSG00000115361)
    Fold Change: N/A
    Ensembl ID: ENSG00000115361
  • Gene Symbol: ACADM (ENSG00000117054)
    Fold Change: N/A
    Ensembl ID: ENSG00000117054
  • Gene Symbol: ACADS (ENSG00000122971)
    Fold Change: N/A
    Ensembl ID: ENSG00000122971
  • Gene Symbol: ACADSB (ENSG00000196177)
    Fold Change: N/A
    Ensembl ID: ENSG00000196177
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: N/A
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ACAT1 (ENSG00000075239)
    Fold Change: N/A
    Ensembl ID: ENSG00000075239
  • Gene Symbol: ACAT2 (ENSG00000120437)
    Fold Change: N/A
    Ensembl ID: ENSG00000120437
  • Gene Symbol: ASIC2 (ENSG00000108684)
    Fold Change: N/A
    Ensembl ID: ENSG00000108684
  • Gene Symbol: ASIC1 (ENSG00000110881)
    Fold Change: N/A
    Ensembl ID: ENSG00000110881
  • Gene Symbol: ACHE (ENSG00000087085)
    Fold Change: N/A
    Ensembl ID: ENSG00000087085
  • Gene Symbol: ACLY (ENSG00000131473)
    Fold Change: N/A
    Ensembl ID: ENSG00000131473
  • Gene Symbol: ACO1 (ENSG00000122729)
    Fold Change: N/A
    Ensembl ID: ENSG00000122729
  • Gene Symbol: ACR (ENSG00000100312)
    Fold Change: N/A
    Ensembl ID: ENSG00000100312
  • Gene Symbol: ACO2 (ENSG00000100412)
    Fold Change: N/A
    Ensembl ID: ENSG00000100412
  • Gene Symbol: ACOX1 (ENSG00000161533)
    Fold Change: N/A
    Ensembl ID: ENSG00000161533
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: N/A
    Ensembl ID: ENSG00000143727
  • Gene Symbol: ACP2 (ENSG00000134575)
    Fold Change: N/A
    Ensembl ID: ENSG00000134575
  • Gene Symbol: ACP5 (ENSG00000102575)
    Fold Change: N/A
    Ensembl ID: ENSG00000102575
  • Gene Symbol: ACP3 (ENSG00000014257)
    Fold Change: N/A
    Ensembl ID: ENSG00000014257
  • Gene Symbol: ACRV1 (ENSG00000134940)
    Fold Change: N/A
    Ensembl ID: ENSG00000134940
  • Gene Symbol: ACTA1 (ENSG00000143632)
    Fold Change: N/A
    Ensembl ID: ENSG00000143632
  • Gene Symbol: ACTA2 (ENSG00000107796)
    Fold Change: N/A
    Ensembl ID: ENSG00000107796
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: N/A
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ACTBP2 (N/A)
    Fold Change: N/A
    Ensembl ID: N/A
  • Gene Symbol: ACTBP3 (N/A)
    Fold Change: N/A
    Ensembl ID: N/A
  • Gene Symbol: ACTBP4 (N/A)
    Fold Change: N/A
    Ensembl ID: N/A
  • Gene Symbol: ACTBP6 (N/A)
    Fold Change: N/A
    Ensembl ID: N/A
  • Gene Symbol: ACTBP7 (N/A)
    Fold Change: N/A
    Ensembl ID: N/A
  • Gene Symbol: ACTBP8 (N/A)
    Fold Change: N/A
    Ensembl ID: N/A
  • Gene Symbol: ACTBP9 (N/A)
    Fold Change: N/A
    Ensembl ID: N/A
  • Gene Symbol: ACTC1 (ENSG00000159251)
    Fold Change: N/A
    Ensembl ID: ENSG00000159251
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: N/A
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ACTG2 (ENSG00000163017)
    Fold Change: N/A
    Ensembl ID: ENSG00000163017
  • Gene Symbol: ACTG1P1 (N/A)
    Fold Change: N/A
    Ensembl ID: N/A
  • Gene Symbol: ACTG1P2 (N/A)
    Fold Change: N/A
    Ensembl ID: N/A
  • Gene Symbol: ACTG1P3 (N/A)
    Fold Change: N/A
    Ensembl ID: N/A
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: N/A
    Ensembl ID: ENSG00000130402
  • Gene Symbol: ACTG1P9 (N/A)
    Fold Change: N/A
    Ensembl ID: N/A
  • Gene Symbol: ACTG1P10 (N/A)
    Fold Change: N/A
    Ensembl ID: N/A
  • Gene Symbol: ACTL6A (ENSG00000136518)
    Fold Change: N/A
    Ensembl ID: ENSG00000136518
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: N/A
    Ensembl ID: ENSG00000072110
  • Gene Symbol: ACTN2 (ENSG00000077522)
    Fold Change: N/A
    Ensembl ID: ENSG00000077522
  • Gene Symbol: ACTN3 (ENSG00000248746)
    Fold Change: N/A
    Ensembl ID: ENSG00000248746
  • Gene Symbol: ACVR1 (ENSG00000115170)
    Fold Change: N/A
    Ensembl ID: ENSG00000115170
  • Gene Symbol: ACVR1B (ENSG00000135503)
    Fold Change: N/A
    Ensembl ID: ENSG00000135503
  • Gene Symbol: ACVR2A (ENSG00000121989)
    Fold Change: N/A
    Ensembl ID: ENSG00000121989
  • Gene Symbol: ACVR2B (ENSG00000114739)
    Fold Change: N/A
    Ensembl ID: ENSG00000114739
  • Gene Symbol: ACVRL1 (ENSG00000139567)
    Fold Change: N/A
    Ensembl ID: ENSG00000139567
  • Gene Symbol: ACY1 (ENSG00000243989)
    Fold Change: N/A
    Ensembl ID: ENSG00000243989
  • Gene Symbol: ACYP1 (ENSG00000119640)
    Fold Change: N/A
    Ensembl ID: ENSG00000119640
  • Gene Symbol: ACYP2 (ENSG00000170634)
    Fold Change: N/A
    Ensembl ID: ENSG00000170634
  • Gene Symbol: ADA (ENSG00000196839)
    Fold Change: N/A
    Ensembl ID: ENSG00000196839
  • Gene Symbol: ADAM8 (ENSG00000151651)
    Fold Change: N/A
    Ensembl ID: ENSG00000151651
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: N/A
    Ensembl ID: ENSG00000137845
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: N/A
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ADARB1 (ENSG00000197381)
    Fold Change: N/A
    Ensembl ID: ENSG00000197381
  • Gene Symbol: ADARB2 (ENSG00000185736)
    Fold Change: N/A
    Ensembl ID: ENSG00000185736
  • Gene Symbol: ADCY1 (ENSG00000164742)
    Fold Change: N/A
    Ensembl ID: ENSG00000164742
  • Gene Symbol: ADCY2 (ENSG00000078295)
    Fold Change: N/A
    Ensembl ID: ENSG00000078295
  • Gene Symbol: ADCY3 (ENSG00000138031)
    Fold Change: N/A
    Ensembl ID: ENSG00000138031
  • Gene Symbol: ADCY5 (ENSG00000173175)
    Fold Change: N/A
    Ensembl ID: ENSG00000173175
  • Gene Symbol: ADCY6 (ENSG00000174233)
    Fold Change: N/A
    Ensembl ID: ENSG00000174233
  • Gene Symbol: ADCY7 (ENSG00000121281)
    Fold Change: N/A
    Ensembl ID: ENSG00000121281
  • Gene Symbol: ADCY8 (ENSG00000155897)
    Fold Change: N/A
    Ensembl ID: ENSG00000155897
  • Gene Symbol: ADCY9 (ENSG00000162104)
    Fold Change: N/A
    Ensembl ID: ENSG00000162104
  • Gene Symbol: ADCYAP1 (ENSG00000141433)
    Fold Change: N/A
    Ensembl ID: ENSG00000141433
  • Gene Symbol: ADCYAP1R1 (ENSG00000078549)
    Fold Change: N/A
    Ensembl ID: ENSG00000078549
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: N/A
    Ensembl ID: ENSG00000087274
  • Gene Symbol: ADD2 (ENSG00000075340)
    Fold Change: N/A
    Ensembl ID: ENSG00000075340
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: N/A
    Ensembl ID: ENSG00000148700
  • Gene Symbol: PLIN2 (ENSG00000147872)
    Fold Change: N/A
    Ensembl ID: ENSG00000147872
  • Gene Symbol: ADH1A (ENSG00000187758)
    Fold Change: N/A
    Ensembl ID: ENSG00000187758
  • Gene Symbol: ADH1B (ENSG00000196616)
    Fold Change: N/A
    Ensembl ID: ENSG00000196616

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the CSI Threshold for immature innate lymphoid cell to Cell Significance Index of immature innate lymphoid cell in specific gene. A fold change greater than 1 suggests significant gene expression.

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the CSI Threshold for immature innate lymphoid cell to Cell Significance Index of immature innate lymphoid cell in specific gene. A fold change greater than 1 suggests significant gene expression.
**Key Characteristics** * Immature innate lymphoid cell (iILC) * Immature phenotype * Involved in type 2 immune responses * Regulates immune responses, particularly in the context of allergic disorders and autoimmune diseases * Expressed genes: CRYAA, CBS, and DLG2 * Pathways/ontology: involved in various cellular processes, including cytoplasm, cytosol, and protein binding **Clinical Significance** The immature innate lymphoid cell (iILC) is a critical component of the innate immune system, and its dysregulation has been implicated in various diseases, including: 1. **Allergic disorders**: iILCs are involved in the regulation of type 2 immune responses, which are characterized by the production of IgE antibodies and the activation of eosinophils. Dysregulation of iILCs has been implicated in the development of allergic disorders, such as asthma and atopic dermatitis. 2. **Autoimmune diseases**: iILCs have been implicated in the regulation of immune responses in autoimmune diseases, such as rheumatoid arthritis and lupus. 3. **Infectious diseases**: iILCs are involved in the regulation of immune responses to infections, particularly in the context of type 2 immune responses. 4. **Cancer**: iILCs have been implicated in the development and progression of various cancers, including breast cancer and lung cancer. The dysregulation of iILCs has been linked to various genetic mutations, including mutations in the CRYAA, CBS, and DLG2 genes. These mutations can lead to impaired immune function and increased susceptibility to disease. **Gene Symbol and Ensembl ID** * Gene Symbol: CRYAA, CBS, and DLG2 * Ensembl ID: ENSG00000160202, ENSG00000160200, and ENSG00000150672, respectively. **Pathways/Ontology** * Cytoplasm, Cytosol, Identical protein binding, Lens development in camera-type eye, Metal ion binding, Negative regulation of apoptotic process, Negative regulation of intracellular transport, Nucleoplasm, Nucleus, Protein-containing complex, Protein binding, Protein refolding, Protein stabilization, Response to heat, Structural constituent of eye lens, Structural molecule activity, Unfolded protein binding, Visual perception * Blood vessel diameter maintenance, Blood vessel remodeling, Carbon monoxide binding, Cartilage development involved in endochondral bone morphogenesis, Cellular response to hypoxia, Cerebellum morphogenesis, Cystathionine beta-synthase activity, Cysteine biosynthetic process, Cysteine biosynthetic process from serine, Cysteine biosynthetic process via cystathionine, Cysteine formation from homocysteine, Cytoplasm, Cytosol, Dna protection, Endochondral ossification, Enzyme binding, Heme binding, Homocysteine catabolic process, Homocysteine metabolic process, Hydrogen sulfide biosynthetic process, Identical protein binding, L-cysteine catabolic process, L-serine catabolic process, L-serine metabolic process, Maternal process involved in female pregnancy, Metabolism, Metabolism of amino acids and derivatives, Metabolism of ingested semet, sec, mesec into h2se, Metal ion binding, Modified amino acid binding, Negative regulation of apoptotic process, Nitric oxide binding, Nitrite reductase (no-forming) activity, Nucleus, Oxygen binding, Protein binding, Protein homodimerization activity, Pyridoxal phosphate binding, Regulation of nitric oxide mediated signal transduction, Response to folic acid, S-adenosyl-l-methionine binding, Selenoamino acid metabolism, Sulfur amino acid metabolism, Superoxide metabolic process, Transsulfuration, Ubiquitin protein ligase binding **Conclusion** The immature innate lymphoid cell (iILC) is a critical component of the innate immune system, and its dysregulation has been implicated in various diseases, including allergic disorders, autoimmune diseases, infectious diseases, and cancer. The dysregulation of iILCs has been linked to various genetic mutations, including mutations in the CRYAA, CBS, and DLG2 genes. Further research is needed to fully understand the role of iILCs in immune function and disease, and to develop effective therapeutic strategies to target iILCs in the treatment of these diseases.