Details for: RGS1

Gene ID: 5996

Symbol: RGS1

Ensembl ID: ENSG00000090104

Description: regulator of G protein signaling 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 209.4246
    Cell Significance Index: -32.5800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 96.2670
    Cell Significance Index: -24.4200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 84.5647
    Cell Significance Index: -34.3600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 79.1527
    Cell Significance Index: -40.7200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 72.9683
    Cell Significance Index: -34.4500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 51.6823
    Cell Significance Index: -34.6800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 26.3310
    Cell Significance Index: -32.4700
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 13.3783
    Cell Significance Index: 55.6800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 13.0850
    Cell Significance Index: -40.1900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.5807
    Cell Significance Index: -33.8600
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 7.9436
    Cell Significance Index: 21.2800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 7.6650
    Cell Significance Index: 118.5900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.0731
    Cell Significance Index: -15.4800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 5.1274
    Cell Significance Index: 128.1700
  • Cell Name: centroblast (CL0009112)
    Fold Change: 2.1774
    Cell Significance Index: 5.0800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.0820
    Cell Significance Index: 245.5300
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 1.3266
    Cell Significance Index: 22.7900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.2989
    Cell Significance Index: 247.1900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8131
    Cell Significance Index: 80.4400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7700
    Cell Significance Index: 695.2100
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.4480
    Cell Significance Index: 4.7600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4095
    Cell Significance Index: 66.6000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.3829
    Cell Significance Index: 5.7700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1863
    Cell Significance Index: 20.2600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.1435
    Cell Significance Index: 89.6000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0311
    Cell Significance Index: 3.1800
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0096
    Cell Significance Index: -0.1400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0168
    Cell Significance Index: -31.6300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0202
    Cell Significance Index: -14.9400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0209
    Cell Significance Index: -0.8600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0228
    Cell Significance Index: -17.2300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0236
    Cell Significance Index: -0.8300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0240
    Cell Significance Index: -1.2100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0255
    Cell Significance Index: -39.2700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0299
    Cell Significance Index: -16.8800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0335
    Cell Significance Index: -45.6000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0524
    Cell Significance Index: -38.4100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0566
    Cell Significance Index: -35.9300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0645
    Cell Significance Index: -35.2400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0677
    Cell Significance Index: -29.9200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0811
    Cell Significance Index: -36.8000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0847
    Cell Significance Index: -2.4400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0856
    Cell Significance Index: -18.0400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0861
    Cell Significance Index: -24.7800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0911
    Cell Significance Index: -32.6800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0919
    Cell Significance Index: -6.3600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1030
    Cell Significance Index: -18.5600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1094
    Cell Significance Index: -4.9600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1330
    Cell Significance Index: -22.7100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1509
    Cell Significance Index: -29.9400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1777
    Cell Significance Index: -35.6500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.2023
    Cell Significance Index: -24.8700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2327
    Cell Significance Index: -33.8200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2353
    Cell Significance Index: -7.5400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.2356
    Cell Significance Index: -32.3500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2714
    Cell Significance Index: -31.6300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2719
    Cell Significance Index: -34.8500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2783
    Cell Significance Index: -35.9600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2809
    Cell Significance Index: -7.1800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.2815
    Cell Significance Index: -16.9000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2865
    Cell Significance Index: -32.7000
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.3179
    Cell Significance Index: -5.4000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3241
    Cell Significance Index: -33.7500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3255
    Cell Significance Index: -15.3000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3490
    Cell Significance Index: -7.5600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3587
    Cell Significance Index: -41.1000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3787
    Cell Significance Index: -23.2200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4097
    Cell Significance Index: -10.9600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4137
    Cell Significance Index: -26.6900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4839
    Cell Significance Index: -37.1300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4840
    Cell Significance Index: -36.0700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.4864
    Cell Significance Index: -34.4000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.5410
    Cell Significance Index: -36.3800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5623
    Cell Significance Index: -11.9800
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.5911
    Cell Significance Index: -4.8200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.6091
    Cell Significance Index: -17.8900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.6339
    Cell Significance Index: -38.9700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.6833
    Cell Significance Index: -35.5900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.6838
    Cell Significance Index: -35.5200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.7027
    Cell Significance Index: -39.4300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.7123
    Cell Significance Index: -33.2100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.7433
    Cell Significance Index: -46.8500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.7569
    Cell Significance Index: -39.7400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.7571
    Cell Significance Index: -32.9200
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.7580
    Cell Significance Index: -6.1400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.8498
    Cell Significance Index: -37.5900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.8837
    Cell Significance Index: -32.4400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.9024
    Cell Significance Index: -18.7200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.9924
    Cell Significance Index: -37.5800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.0057
    Cell Significance Index: -35.2300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -1.0184
    Cell Significance Index: -28.4600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.0983
    Cell Significance Index: -35.9600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.1157
    Cell Significance Index: -35.5400
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -1.1160
    Cell Significance Index: -11.1900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.1318
    Cell Significance Index: -39.3300
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -1.1664
    Cell Significance Index: -6.3600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.1904
    Cell Significance Index: -30.6000
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -1.2556
    Cell Significance Index: -20.6900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -1.2704
    Cell Significance Index: -23.4800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -1.2748
    Cell Significance Index: -36.3800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** RGS1 is a small protein that functions as a GTPase-activating protein (GAP) for Gα subunits of G proteins. This activity regulates the GTP hydrolysis cycle, thereby modulating the duration and intensity of signal transduction events. RGS1 is specifically expressed in cells that play a critical role in the immune response, including natural killer cells, T cells, and dendritic cells. Its expression is also observed in other cell types, such as basophils, mast cells, and platelets. **Pathways and Functions:** RGS1 is involved in multiple signaling pathways, including: 1. **Adenylate cyclase-inhibiting GPCR signaling pathway**: RGS1 regulates the activity of adenylate cyclase, an enzyme that converts ATP into cyclic AMP (cAMP), a key secondary messenger molecule. 2. **Leukotriene signaling pathway**: RGS1 modulates the activity of leukotriene receptors, which are involved in the regulation of inflammatory responses. 3. **G-protein alpha-subunit binding**: RGS1 interacts with Gα subunits of G proteins, regulating their GTPase activity and thereby modulating signal transduction events. 4. **Negative regulation of signal transduction**: RGS1 acts as a negative regulator of signal transduction, mitigating the effects of excessive GPCR stimulation. **Clinical Significance:** Dysregulation of RGS1 has been implicated in various diseases, including: 1. **Allergic disorders**: RGS1 deficiency has been linked to an increased susceptibility to allergic responses, highlighting the gene's role in regulating immune responses to allergens. 2. **Autoimmune diseases**: Alterations in RGS1 expression have been observed in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, suggesting its involvement in the regulation of immune responses. 3. **Cancer**: RGS1 has been implicated in cancer development and progression, particularly in the regulation of cell proliferation and survival pathways. In conclusion, RGS1 is a critical gene involved in the regulation of signal transduction pathways, particularly those mediated by G protein-coupled receptors. Its dysregulation has been implicated in various diseases, highlighting the importance of RGS1 in the immune system and its potential as a therapeutic target for the treatment of immune-related disorders. **References:** * [Insert relevant references to support the discussion]

Genular Protein ID: 3819486647

Symbol: RGS1_HUMAN

Name: Regulator of G-protein signaling 1

UniProtKB Accession Codes:

Q08116 B2RDM9 B4DZY0 Q07918 Q9H1W2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 2 EvolutionaryTrace 1 GO 15 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8473738

Title: Isolation and characterization of a novel B cell activation gene.

PubMed ID: 8473738

PubMed ID: 8241276

Title: A B cell specific immediate early human gene is located on chromosome band 1q31 and encodes an alpha helical basic phosphoprotein.

PubMed ID: 8241276

DOI: 10.1016/0167-4781(93)90163-8

PubMed ID: 10480894

Title: RGS1 is expressed in monocytes and acts as a GTPase-activating protein for G-protein-coupled chemoattractant receptors.

PubMed ID: 10480894

DOI: 10.1074/jbc.274.38.26860

PubMed ID: 18434541

Title: Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.

PubMed ID: 18434541

DOI: 10.1073/pnas.0801508105

Sequence Information:

  • Length: 209
  • Mass: 23858
  • Checksum: D8D7D8E80819496A
  • Sequence:
    • MRAAAISTPK LDKMPGMFFS ANPKELKGTT HSLLDDKMQK RRPKTFGMDM KAYLRSMIPH 
LESGMKSSKS KDVLSAAEVM QWSQSLEKLL ANQTGQNVFG SFLKSEFSEE NIEFWLACED 
YKKTESDLLP CKAEEIYKAF VHSDAAKQIN IDFRTRESTA KKIKAPTPTC FDEAQKVIYT 
LMEKDSYPRF LKSDIYLNLL NDLQANSLK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.