Details for: CL0000766

Cell ID: CL0000766

Cell Name: myeloid leukocyte

Marker Score Threshold: 1207
(Derived using integrated single-cell and genomic data)

Description: A cell of the monocyte, granulocyte, or mast cell lineage.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 4.19
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 4.07
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 3.89
    Ensembl ID: ENSG00000149925
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 3.58
    Ensembl ID: ENSG00000145741
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 3.54
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 3.46
    Ensembl ID: ENSG00000164111
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 3.4
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 3.16
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 3.04
    Ensembl ID: ENSG00000169020
  • Gene Symbol: AOAH (ENSG00000136250)
    Fold Change: 3.04
    Ensembl ID: ENSG00000136250
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 3.04
    Ensembl ID: ENSG00000177105
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 3.02
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 3.01
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 2.98
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.93
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ATP6V1B2 (ENSG00000147416)
    Fold Change: 2.79
    Ensembl ID: ENSG00000147416
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 2.7
    Ensembl ID: ENSG00000004059
  • Gene Symbol: BID (ENSG00000015475)
    Fold Change: 2.68
    Ensembl ID: ENSG00000015475
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 2.66
    Ensembl ID: ENSG00000135046
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 2.58
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ARRB2 (ENSG00000141480)
    Fold Change: 2.46
    Ensembl ID: ENSG00000141480
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 2.45
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 2.39
    Ensembl ID: ENSG00000152234
  • Gene Symbol: AKR1B1 (ENSG00000085662)
    Fold Change: 2.35
    Ensembl ID: ENSG00000085662
  • Gene Symbol: AP1B1 (ENSG00000100280)
    Fold Change: 2.32
    Ensembl ID: ENSG00000100280
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 2.29
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 2.27
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 2.18
    Ensembl ID: ENSG00000165629
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 2.15
    Ensembl ID: ENSG00000087088
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 2.14
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 2.13
    Ensembl ID: ENSG00000122359
  • Gene Symbol: BLVRB (ENSG00000090013)
    Fold Change: 2.13
    Ensembl ID: ENSG00000090013
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 2.11
    Ensembl ID: ENSG00000138279
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.94
    Ensembl ID: ENSG00000130303
  • Gene Symbol: ANXA6 (ENSG00000197043)
    Fold Change: 1.92
    Ensembl ID: ENSG00000197043
  • Gene Symbol: PLIN2 (ENSG00000147872)
    Fold Change: 1.91
    Ensembl ID: ENSG00000147872
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.91
    Ensembl ID: ENSG00000165527
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.86
    Ensembl ID: ENSG00000100300
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 1.86
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 1.84
    Ensembl ID: ENSG00000124172
  • Gene Symbol: C1QA (ENSG00000173372)
    Fold Change: 1.82
    Ensembl ID: ENSG00000173372
  • Gene Symbol: AIF1 (ENSG00000204472)
    Fold Change: 1.82
    Ensembl ID: ENSG00000204472
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 1.78
    Ensembl ID: ENSG00000135390
  • Gene Symbol: BCL2A1 (ENSG00000140379)
    Fold Change: 1.78
    Ensembl ID: ENSG00000140379
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 1.78
    Ensembl ID: ENSG00000196975
  • Gene Symbol: GRK2 (ENSG00000173020)
    Fold Change: 1.76
    Ensembl ID: ENSG00000173020
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 1.71
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ACAA1 (ENSG00000060971)
    Fold Change: 1.7
    Ensembl ID: ENSG00000060971
  • Gene Symbol: BIN1 (ENSG00000136717)
    Fold Change: 1.67
    Ensembl ID: ENSG00000136717
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.64
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ARL2 (ENSG00000213465)
    Fold Change: 1.63
    Ensembl ID: ENSG00000213465
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.59
    Ensembl ID: ENSG00000004455
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.57
    Ensembl ID: ENSG00000115307
  • Gene Symbol: APOA4 (ENSG00000110244)
    Fold Change: 1.55
    Ensembl ID: ENSG00000110244
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.55
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ABCF1 (ENSG00000204574)
    Fold Change: 1.55
    Ensembl ID: ENSG00000204574
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.53
    Ensembl ID: ENSG00000143761
  • Gene Symbol: PRDM1 (ENSG00000057657)
    Fold Change: 1.52
    Ensembl ID: ENSG00000057657
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.5
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.47
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.47
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.46
    Ensembl ID: ENSG00000160710
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: 1.45
    Ensembl ID: ENSG00000072110
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.39
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.38
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ALOX5AP (ENSG00000132965)
    Fold Change: 1.38
    Ensembl ID: ENSG00000132965
  • Gene Symbol: ADH5 (ENSG00000197894)
    Fold Change: 1.35
    Ensembl ID: ENSG00000197894
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.35
    Ensembl ID: ENSG00000100823
  • Gene Symbol: ANXA3 (ENSG00000138772)
    Fold Change: 1.34
    Ensembl ID: ENSG00000138772
  • Gene Symbol: ACO2 (ENSG00000100412)
    Fold Change: 1.33
    Ensembl ID: ENSG00000100412
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.33
    Ensembl ID: ENSG00000087274
  • Gene Symbol: BNIP2 (ENSG00000140299)
    Fold Change: 1.33
    Ensembl ID: ENSG00000140299
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.31
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.3
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.29
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATP6V1C1 (ENSG00000155097)
    Fold Change: 1.29
    Ensembl ID: ENSG00000155097
  • Gene Symbol: BIRC2 (ENSG00000110330)
    Fold Change: 1.28
    Ensembl ID: ENSG00000110330
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.27
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.25
    Ensembl ID: ENSG00000072778
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.25
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ATP6V0A1 (ENSG00000033627)
    Fold Change: 1.25
    Ensembl ID: ENSG00000033627
  • Gene Symbol: RND3 (ENSG00000115963)
    Fold Change: 1.25
    Ensembl ID: ENSG00000115963
  • Gene Symbol: AP2A2 (ENSG00000183020)
    Fold Change: 1.25
    Ensembl ID: ENSG00000183020
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 1.21
    Ensembl ID: ENSG00000169100
  • Gene Symbol: APOC3 (ENSG00000110245)
    Fold Change: 1.21
    Ensembl ID: ENSG00000110245
  • Gene Symbol: BACH1 (ENSG00000156273)
    Fold Change: 1.16
    Ensembl ID: ENSG00000156273
  • Gene Symbol: ABR (ENSG00000159842)
    Fold Change: 1.14
    Ensembl ID: ENSG00000159842
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.13
    Ensembl ID: ENSG00000128272
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.12
    Ensembl ID: ENSG00000104964
  • Gene Symbol: AAMP (ENSG00000127837)
    Fold Change: 1.11
    Ensembl ID: ENSG00000127837
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.11
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ALOX5 (ENSG00000012779)
    Fold Change: 1.11
    Ensembl ID: ENSG00000012779
  • Gene Symbol: APOE (ENSG00000130203)
    Fold Change: 1.1
    Ensembl ID: ENSG00000130203
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.1
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ARL1 (ENSG00000120805)
    Fold Change: 1.08
    Ensembl ID: ENSG00000120805
  • Gene Symbol: GET3 (ENSG00000198356)
    Fold Change: 1.07
    Ensembl ID: ENSG00000198356
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.03
    Ensembl ID: ENSG00000177556
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.03
    Ensembl ID: ENSG00000005022
  • Gene Symbol: APAF1 (ENSG00000120868)
    Fold Change: 1.02
    Ensembl ID: ENSG00000120868
  • Gene Symbol: ALDH2 (ENSG00000111275)
    Fold Change: 1
    Ensembl ID: ENSG00000111275
Hovered Details

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Hovered Details

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**Key Characteristics** * **Cell Lineage**: Myeloid leukocyte, derived from hematopoietic stem cells in the bone marrow * **Gene Expression**: ActB (ACTB) gene symbol, involved in actin cytoskeleton organization and cell signaling * **Pathways/Ontologies**: Actin cytoskeleton, Adherens junctions interactions, Angiogenesis, Apical junction complex, Atp binding, Axon, Axon guidance, Axonogenesis, Basal body patch, Blood microparticle, Calyx of held, Cell-cell communication, Cell-cell junction, Cell-cell junction organization, Cell-extracellular matrix interactions, Cell junction organization, Cell motility, Cellular response to type II interferon, Clathrin-mediated endocytosis, Cytoplasm, Cytoskeleton, Cytosol, Dense body, Developmental biology, Disease, Diseases of signal transduction by growth factor receptors and second messengers, Eph-ephrin mediated repulsion of cells, Eph-ephrin signaling, Ephb-mediated forward signaling, Extracellular exosome, Extracellular space, Fcgamma receptor (fcgr) dependent phagocytosis, Fcgr3a-mediated phagocytosis, Filamentous actin, Focal adhesion, Formation of annular gap junctions, Gap junction degradation, Gap junction trafficking, Gap junction trafficking and regulation, Hydrolase activity, Identical protein binding, Immune system, Infectious disease, Innate immune system, Interaction between L1 and ankyrins, L1cam interactions, Leishmania infection, Leishmania phagocytosis, Maintenance of blood-brain barrier, Map2k and mapk activation, Mapk1/mapk3 signaling, Mapk family signaling cascades, Membrane, Membrane trafficking, Morphogenesis of a polarized epithelium, Myofibril, Nervous system development, Nua4 histone acetyltransferase complex, Nucleus, Oncogenic mapk signaling, Paradoxical activation of raf signaling by kinase inactive braf, Parasite infection, Parasitic infection pathways, Phagocytic vesicle, Plasma membrane, Platelet aggregation, Positive regulation of cell migration, Positive regulation of gene expression, Positive regulation of wound healing, Postsynaptic actin cytoskeleton organization, Profilin binding, Protein binding, Protein kinase binding, Protein localization to bicellular tight junction, Raf/map kinase cascade, Recycling pathway of L1, Regulation of actin dynamics for phagocytic cup formation, Regulation of focal adhesion assembly, Regulation of stress fiber assembly, Regulation of synaptic vesicle endocytosis, Regulation of transepithelial transport, Rhobtb2 gtpase cycle, Rhobtb gtpase cycle, Rho gtpase cycle, Rho gtpase effectors, Rho gtpases activate formins, Rho gtpases activate iqgaps, Rho gtpases activate wasps and waves, Sarcomere organization, Schaffer collateral - CA1 synapse, Sensory perception, Sensory processing of sound, Sensory processing of sound by inner hair cells of the cochlea, Swi/Snf complex, Synapse, Tat protein binding, Tau protein binding, Tight junction, Translocation of SLC2A4 (glut4) to the plasma membrane, Uch proteinases, Vegfa-vegfr2 pathway, Vesicle, Vesicle-mediated transport **Clinical Significance** Myeloid leukocytes play a crucial role in the immune system, providing defense against infections and diseases. The cell's characteristics and functions are closely related to its gene expression profile, which includes genes involved in cell signaling, adhesion, and cytoskeleton organization. The cell's interactions with various cellular components and response to different stimuli are reflected in its pathways and ontologies, which include angiogenesis, apical junction complex, ATP binding, axon, and axon guidance. These interactions are critical in various clinical contexts, such as: * **Infections**: Myeloid leukocytes are essential in the innate immune response, providing immediate defense against infections. * **Cancer**: The cell's ability to interact with various cellular components and respond to different stimuli is critical in the development and progression of cancer. * **Neurological disorders**: The cell's interactions with the nervous system, including axon guidance and synapse formation, are critical in the development and progression of neurological disorders, such as Alzheimer's disease and Parkinson's disease. * **Cardiovascular disease**: The cell's ability to interact with the extracellular matrix and regulate cell migration is critical in the development and progression of cardiovascular disease. Overall, the myeloid leukocyte is a complex cell that plays a critical role in the immune system, and its characteristics and functions are closely related to its gene expression profile and interactions with various cellular components.