Details for: FCGR3A

Gene ID: 2214

Symbol: FCGR3A

Ensembl ID: ENSG00000203747

Description: Fc gamma receptor IIIa

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 114.3076
    Cell Significance Index: -17.7800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 73.1736
    Cell Significance Index: -18.5600
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 50.2208
    Cell Significance Index: 132.4800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 42.8278
    Cell Significance Index: -22.0300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 14.5098
    Cell Significance Index: -17.8900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 10.5192
    Cell Significance Index: 218.2100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.3660
    Cell Significance Index: -19.7300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 4.3325
    Cell Significance Index: 67.0300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 4.3139
    Cell Significance Index: 107.8400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 2.8877
    Cell Significance Index: 92.4900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.0127
    Cell Significance Index: 43.6100
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 1.6182
    Cell Significance Index: 4.3400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.4840
    Cell Significance Index: 67.2700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.1136
    Cell Significance Index: 211.9200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.0744
    Cell Significance Index: 28.7400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.9995
    Cell Significance Index: 8.1500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9230
    Cell Significance Index: 91.3100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7109
    Cell Significance Index: 641.8700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.4886
    Cell Significance Index: 361.9000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.4698
    Cell Significance Index: 7.0800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4549
    Cell Significance Index: 73.9800
  • Cell Name: activated type II NK T cell (CL0000931)
    Fold Change: 0.4375
    Cell Significance Index: 1.1200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2901
    Cell Significance Index: 31.5600
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.2613
    Cell Significance Index: 2.7800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.1850
    Cell Significance Index: 3.4200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.1547
    Cell Significance Index: 44.5100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.1029
    Cell Significance Index: 21.6800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0506
    Cell Significance Index: 3.5000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0423
    Cell Significance Index: 26.4400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0383
    Cell Significance Index: 0.8200
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.0336
    Cell Significance Index: 0.1400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0322
    Cell Significance Index: 3.2900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0047
    Cell Significance Index: -0.2900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0049
    Cell Significance Index: -2.7800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0074
    Cell Significance Index: -0.2600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0092
    Cell Significance Index: -1.8400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0095
    Cell Significance Index: -17.9500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0112
    Cell Significance Index: -8.5000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0145
    Cell Significance Index: -26.6700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0146
    Cell Significance Index: -0.4200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0169
    Cell Significance Index: -26.0900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0223
    Cell Significance Index: -3.8100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0302
    Cell Significance Index: -22.1600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0336
    Cell Significance Index: -21.3700
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0444
    Cell Significance Index: -0.6500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0499
    Cell Significance Index: -17.8900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0502
    Cell Significance Index: -2.0600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0506
    Cell Significance Index: -22.9500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1010
    Cell Significance Index: -5.1000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.1018
    Cell Significance Index: -6.1100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1026
    Cell Significance Index: -20.5800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1109
    Cell Significance Index: -19.9900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1365
    Cell Significance Index: -18.7400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1393
    Cell Significance Index: -15.9000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1404
    Cell Significance Index: -20.4100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1593
    Cell Significance Index: -20.5800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1617
    Cell Significance Index: -18.5300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1641
    Cell Significance Index: -20.1800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1685
    Cell Significance Index: -4.3300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1935
    Cell Significance Index: -24.8100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1945
    Cell Significance Index: -9.1400
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.2049
    Cell Significance Index: -3.4800
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: -0.2168
    Cell Significance Index: -1.9300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2416
    Cell Significance Index: -18.5400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2432
    Cell Significance Index: -5.8900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2514
    Cell Significance Index: -10.9300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2745
    Cell Significance Index: -20.4600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2871
    Cell Significance Index: -4.9200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2880
    Cell Significance Index: -17.7000
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.2940
    Cell Significance Index: -2.5900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2985
    Cell Significance Index: -20.0700
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.3055
    Cell Significance Index: -4.0600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3202
    Cell Significance Index: -20.1800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3305
    Cell Significance Index: -21.3200
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.3376
    Cell Significance Index: -2.7400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3663
    Cell Significance Index: -19.0800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3728
    Cell Significance Index: -20.9200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3746
    Cell Significance Index: -19.4600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3973
    Cell Significance Index: -20.8600
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: -0.4434
    Cell Significance Index: -3.7500
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.4511
    Cell Significance Index: -6.5500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.4542
    Cell Significance Index: -5.1600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4761
    Cell Significance Index: -21.0600
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.4912
    Cell Significance Index: -5.0200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4969
    Cell Significance Index: -23.1700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5556
    Cell Significance Index: -21.0400
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.5573
    Cell Significance Index: -5.1000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5772
    Cell Significance Index: -21.1900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5920
    Cell Significance Index: -20.7400
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.6337
    Cell Significance Index: -5.5400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.6363
    Cell Significance Index: -16.9900
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: -0.6390
    Cell Significance Index: -6.2400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6518
    Cell Significance Index: -21.3400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.6531
    Cell Significance Index: -17.5000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6735
    Cell Significance Index: -21.4500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.6777
    Cell Significance Index: -13.2500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.7005
    Cell Significance Index: -19.9900
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.7058
    Cell Significance Index: -8.7300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.7260
    Cell Significance Index: -19.0900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.7277
    Cell Significance Index: -20.8600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Structure**: FCGR3A is a type of low-affinity IgG receptor, also known as CD16a. It consists of two immunoglobulin-like domains, which are responsible for binding to the Fc region of IgG antibodies. 2. **Expression**: FCGR3A is expressed on various immune cells, including natural killer cells, monocytes, macrophages, and T cells. The expression of FCGR3A is often associated with the presence of specific surface markers, such as CD16 and CD14. 3. **Function**: FCGR3A plays a critical role in the recognition and clearance of pathogens. It is involved in antibody-dependent cellular cytotoxicity, phagocytosis, and the regulation of immune responses. 4. **Evolutionary Conservation**: FCGR3A is highly conserved across species, suggesting its importance in the immune system. **Pathways and Functions** 1. **Antibody-Dependent Cellular Cytotoxicity (ADCC)**: FCGR3A is involved in ADCC, a process by which immune cells recognize and kill pathogens that are opsonized by IgG antibodies. 2. **Phagocytosis**: FCGR3A plays a role in phagocytosis, the process by which immune cells engulf and clear pathogens. 3. **Calcium-Mediated Signaling**: FCGR3A is involved in calcium-mediated signaling pathways, which are critical for the regulation of immune responses. 4. **Regulation of Immune Responses**: FCGR3A regulates immune responses by modulating the activity of immune cells, including natural killer cells and macrophages. 5. **Leishmania Infection**: FCGR3A is involved in the regulation of Leishmania parasite growth and survival, suggesting its importance in the immune response to this pathogen. **Clinical Significance** 1. **Infectious Diseases**: FCGR3A is involved in the regulation of immune responses to various infectious diseases, including Leishmania and other parasitic infections. 2. **Cancer**: FCGR3A is overexpressed on the surface of certain cancer cells, suggesting its potential role in cancer progression and metastasis. 3. **Autoimmune Diseases**: FCGR3A is involved in the regulation of immune responses in autoimmune diseases, such as rheumatoid arthritis and lupus. 4. **Immunodeficiency Disorders**: FCGR3A is involved in the regulation of immune responses in immunodeficiency disorders, such as chronic granulomatous disease. 5. **Vaccine Development**: FCGR3A is a potential target for vaccine development, as it plays a critical role in the immune response to certain pathogens. In conclusion, FCGR3A is a critical component of the immune system, involved in various immune-related processes, including antibody-dependent cellular cytotoxicity, phagocytosis, and the regulation of immune responses. Its dysregulation has been implicated in various diseases, including infectious diseases, cancer, autoimmune diseases, and immunodeficiency disorders.

Genular Protein ID: 293288408

Symbol: FCG3A_HUMAN

Name: CD16a antigen

UniProtKB Accession Codes:

P08637 A2N6W9 Q53FJ0 Q53FL6 Q5EBR4 Q65ZM6 Q6PIJ0

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 13 DrugCentral 1 EMBL 9 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 21 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 14 PDBsum 14 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 6 RefSeq 6 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TopDownProteomics 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2526846

Title: Alternative membrane forms of Fc gamma RIII(CD16) on human natural killer cells and neutrophils. Cell type-specific expression of two genes that differ in single nucleotide substitutions.

PubMed ID: 2526846

DOI: 10.1084/jem.170.2.481

PubMed ID: 16951347

Title: IgG Fc receptor III homologues in nonhuman primate species: genetic characterization and ligand interactions.

PubMed ID: 16951347

DOI: 10.4049/jimmunol.177.6.3848

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7836402

Title: The human low affinity immunoglobulin G Fc receptor III-A and III-B genes. Molecular characterization of the promoter regions.

PubMed ID: 7836402

DOI: 10.1074/jbc.270.3.1350

PubMed ID: 7700021

Title: Human glomerular mesangial cells express CD16 and may be stimulated via this receptor.

PubMed ID: 7700021

DOI: 10.1038/ki.1994.462

PubMed ID: 2525780

Title: A human immunoglobulin G receptor exists in both polypeptide-anchored and phosphatidylinositol-glycan-anchored forms.

PubMed ID: 2525780

DOI: 10.1073/pnas.86.13.5079

PubMed ID: 2532305

Title: Co-association of CD3 zeta with a receptor (CD16) for IgG Fc on human natural killer cells.

PubMed ID: 2532305

DOI: 10.1038/342803a0

PubMed ID: 1825220

Title: Analysis of Fc gamma RIII (CD16) membrane expression and association with CD3 zeta and Fc epsilon RI-gamma by site-directed mutation.

PubMed ID: 1825220

PubMed ID: 7955033

Title: Nomenclature of Fc receptors. IUIS/WHO Subcommittee on Nomenclature of Fc receptors.

PubMed ID: 7955033

PubMed ID: 9916693

Title: Quantitative analysis of the effect of CD16 ligation on human NK cell proliferation.

PubMed ID: 9916693

PubMed ID: 10318937

Title: Human CD16 as a lysis receptor mediating direct natural killer cell cytotoxicity.

PubMed ID: 10318937

DOI: 10.1073/pnas.96.10.5640

PubMed ID: 11711607

Title: Effector function activities of a panel of mutants of a broadly neutralizing antibody against human immunodeficiency virus type 1.

PubMed ID: 11711607

DOI: 10.1128/jvi.75.24.12161-12168.2001

PubMed ID: 23024279

Title: The unique cytoplasmic domain of human FcgammaRIIIA regulates receptor-mediated function.

PubMed ID: 23024279

DOI: 10.4049/jimmunol.1200704

PubMed ID: 24337742

Title: ADAM17-mediated shedding of FcgammaRIIIA on human NK cells: identification of the cleavage site and relationship with activation.

PubMed ID: 24337742

DOI: 10.4049/jimmunol.1301024

PubMed ID: 24412922

Title: Broadly neutralizing hemagglutinin stalk-specific antibodies require FcgammaR interactions for protection against influenza virus in vivo.

PubMed ID: 24412922

DOI: 10.1038/nm.3443

PubMed ID: 25786175

Title: Epigenetic modification and antibody-dependent expansion of memory-like NK cells in human cytomegalovirus-infected individuals.

PubMed ID: 25786175

DOI: 10.1016/j.immuni.2015.02.013

PubMed ID: 25816339

Title: Identification of an ADAM17 cleavage region in human CD16 (FcgammaRIII) and the engineering of a non-cleavable version of the receptor in NK cells.

PubMed ID: 25816339

DOI: 10.1371/journal.pone.0121788

PubMed ID: 27670158

Title: CD16 is indispensable for antibody-dependent cellular cytotoxicity by human monocytes.

PubMed ID: 27670158

DOI: 10.1038/srep34310

PubMed ID: 28652325

Title: Transmembrane features governing Fc receptor CD16A assembly with CD16A signaling adaptor molecules.

PubMed ID: 28652325

DOI: 10.1073/pnas.1706483114

PubMed ID: 28126818

Title: IgG antibodies to dengue enhanced for FcgammaRIIIA binding determine disease severity.

PubMed ID: 28126818

DOI: 10.1126/science.aai8128

PubMed ID: 29967280

Title: Shedding of CD16 disassembles the NK cell immune synapse and boosts serial engagement of target cells.

PubMed ID: 29967280

DOI: 10.1083/jcb.201712085

PubMed ID: 31244843

Title: Evolutionary Story of the Low/Medium-Affinity IgG Fc Receptor Gene Cluster.

PubMed ID: 31244843

DOI: 10.3389/fimmu.2019.01297

PubMed ID: 34485821

Title: Cross-species higher sensitivities of FcgammaRIIIA/FcgammaRIV to afucosylated IgG for enhanced ADCC.

PubMed ID: 34485821

DOI: 10.1093/abt/tbab016

PubMed ID: 22023369

Title: Structural basis for improved efficacy of therapeutic antibodies on defucosylation of their Fc glycans.

PubMed ID: 22023369

DOI: 10.1111/j.1365-2443.2011.01552.x

PubMed ID: 21768335

Title: Unique carbohydrate-carbohydrate interactions are required for high affinity binding between FcgammaRIII and antibodies lacking core fucose.

PubMed ID: 21768335

DOI: 10.1073/pnas.1108455108

PubMed ID: 8609432

Title: A triallelic Fc gamma receptor type IIIA polymorphism influences the binding of human IgG by NK cell Fc gamma RIIIa.

PubMed ID: 8609432

PubMed ID: 9242542

Title: Fc gammaRIIIa-158V/F polymorphism influences the binding of IgG by natural killer cell Fc gammaRIIIa, independently of the Fc gammaRIIIa-48L/R/H phenotype.

PubMed ID: 9242542

PubMed ID: 9276722

Title: A novel polymorphism of FcgammaRIIIa (CD16) alters receptor function and predisposes to autoimmune disease.

PubMed ID: 9276722

DOI: 10.1172/jci119616

PubMed ID: 8874200

Title: Identification of an unusual Fc gamma receptor IIIa (CD16) on natural killer cells in a patient with recurrent infections.

PubMed ID: 8874200

PubMed ID: 8608639

Title: Natural Killer (NK) cell deficiency associated with an epitope-deficient Fc receptor type IIIA (CD16-II).

PubMed ID: 8608639

DOI: 10.1111/j.1365-2249.1996.tb08295.x

PubMed ID: 23006327

Title: Human immunodeficiency-causing mutation defines CD16 in spontaneous NK cell cytotoxicity.

PubMed ID: 23006327

DOI: 10.1172/jci64837

Sequence Information:

  • Length: 254
  • Mass: 29089
  • Checksum: D38D178D32C67337
  • Sequence:
    • MWQLLLPTAL LLLVSAGMRT EDLPKAVVFL EPQWYRVLEK DSVTLKCQGA YSPEDNSTQW 
FHNESLISSQ ASSYFIDAAT VDDSGEYRCQ TNLSTLSDPV QLEVHIGWLL LQAPRWVFKE 
EDPIHLRCHS WKNTALHKVT YLQNGKGRKY FHHNSDFYIP KATLKDSGSY FCRGLFGSKN 
VSSETVNITI TQGLAVSTIS SFFPPGYQVS FCLVMVLLFA VDTGLYFSVK TNIRSSTRDW 
KDHKFKWRKD PQDK

Genular Protein ID: 1971792469

Symbol: H0Y755_HUMAN

Name: N/A

UniProtKB Accession Codes:

H0Y755

Database IDs:

ARBA 2 Antibodypedia 1 Bgee 1 CDD 2 CTD 1 ChiTaRS 1 DisGeNET 1 EMBL 1 Ensembl 3 GO 2 Gene3D 1 GeneTree 1 HGNC 1 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 2 SMART 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

Sequence Information:

  • Length: 253
  • Mass: 28960
  • Checksum: 217F780E7D054156
  • Sequence:
    • MWQLLLPTAL LLLVSAGMRT DLPKAVVFLE PQWYRVLEKD SVTLKCQGAY SPEDNSTQWF 
HNESLISSQA SSYFIDAATV DDSGEYRCQT NLSTLSDPVQ LEVHIGWLLL QAPRWVFKEE 
DPIHLRCHSW KNTALHKVTY LQNGKGRKYF HHNSDFYIPK ATLKDSGSYF CRGLFGSKNV 
SSETVNITIT QGLAVSTISS FFPPGYQVSF CLVMVLLFAV DTGLYFSVKT NIRSSTRDWK 
DHKFKWRKDP QDK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.