Details for: CL0000235

Cell ID: CL0000235

Cell Name: macrophage

Marker Score Threshold: 1112
(Derived using integrated single-cell and genomic data)

Description: A mononuclear phagocyte present in variety of tissues, typically differentiated from monocytes, capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells.

Synonyms: histiocyte

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.88
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.86
    Ensembl ID: ENSG00000166710
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.38
    Ensembl ID: ENSG00000198668
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.35
    Ensembl ID: ENSG00000145741
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.21
    Ensembl ID: ENSG00000067560
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.16
    Ensembl ID: ENSG00000169100
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.09
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.09
    Ensembl ID: ENSG00000185650
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 2.07
    Ensembl ID: ENSG00000077549
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.02
    Ensembl ID: ENSG00000184009
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.95
    Ensembl ID: ENSG00000179218
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.94
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 1.86
    Ensembl ID: ENSG00000124172
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 1.85
    Ensembl ID: ENSG00000143933
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.85
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 1.84
    Ensembl ID: ENSG00000135390
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.84
    Ensembl ID: ENSG00000005022
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.82
    Ensembl ID: ENSG00000127022
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.81
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.79
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.77
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.75
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.73
    Ensembl ID: ENSG00000152518
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.66
    Ensembl ID: ENSG00000153113
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.66
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.64
    Ensembl ID: ENSG00000111348
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.63
    Ensembl ID: ENSG00000104763
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.6
    Ensembl ID: ENSG00000198931
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.59
    Ensembl ID: ENSG00000100300
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.57
    Ensembl ID: ENSG00000116489
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 1.57
    Ensembl ID: ENSG00000135046
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.57
    Ensembl ID: ENSG00000198898
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.56
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.53
    Ensembl ID: ENSG00000069849
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.52
    Ensembl ID: ENSG00000160014
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.52
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.51
    Ensembl ID: ENSG00000141522
  • Gene Symbol: C1QB (ENSG00000173369)
    Fold Change: 1.51
    Ensembl ID: ENSG00000173369
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.48
    Ensembl ID: ENSG00000154518
  • Gene Symbol: BLVRB (ENSG00000090013)
    Fold Change: 1.47
    Ensembl ID: ENSG00000090013
  • Gene Symbol: C1QA (ENSG00000173372)
    Fold Change: 1.47
    Ensembl ID: ENSG00000173372
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.46
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.46
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 1.45
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.45
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.44
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.44
    Ensembl ID: ENSG00000177556
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.43
    Ensembl ID: ENSG00000128272
  • Gene Symbol: C1QC (ENSG00000159189)
    Fold Change: 1.39
    Ensembl ID: ENSG00000159189
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.37
    Ensembl ID: ENSG00000099624
  • Gene Symbol: PLIN2 (ENSG00000147872)
    Fold Change: 1.37
    Ensembl ID: ENSG00000147872
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.36
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.36
    Ensembl ID: ENSG00000168374
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.35
    Ensembl ID: ENSG00000130303
  • Gene Symbol: AIF1 (ENSG00000204472)
    Fold Change: 1.35
    Ensembl ID: ENSG00000204472
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.3
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.28
    Ensembl ID: ENSG00000072778
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.25
    Ensembl ID: ENSG00000146731
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.25
    Ensembl ID: ENSG00000152234
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.22
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.22
    Ensembl ID: ENSG00000137845
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.22
    Ensembl ID: ENSG00000130402
  • Gene Symbol: CAPNS1 (ENSG00000126247)
    Fold Change: 1.22
    Ensembl ID: ENSG00000126247
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.21
    Ensembl ID: ENSG00000085224
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.21
    Ensembl ID: ENSG00000183255
  • Gene Symbol: C5AR1 (ENSG00000197405)
    Fold Change: 1.2
    Ensembl ID: ENSG00000197405
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.2
    Ensembl ID: ENSG00000165629
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.2
    Ensembl ID: ENSG00000177105
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.2
    Ensembl ID: ENSG00000087088
  • Gene Symbol: APOE (ENSG00000130203)
    Fold Change: 1.19
    Ensembl ID: ENSG00000130203
  • Gene Symbol: ARRB2 (ENSG00000141480)
    Fold Change: 1.19
    Ensembl ID: ENSG00000141480
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.19
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.19
    Ensembl ID: ENSG00000241837
  • Gene Symbol: A2M (ENSG00000175899)
    Fold Change: 1.18
    Ensembl ID: ENSG00000175899
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.16
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ALDH2 (ENSG00000111275)
    Fold Change: 1.16
    Ensembl ID: ENSG00000111275
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.15
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ATF3 (ENSG00000162772)
    Fold Change: 1.15
    Ensembl ID: ENSG00000162772
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.15
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.15
    Ensembl ID: ENSG00000138279
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.14
    Ensembl ID: ENSG00000123505
  • Gene Symbol: CAPG (ENSG00000042493)
    Fold Change: 1.14
    Ensembl ID: ENSG00000042493
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.13
    Ensembl ID: ENSG00000100823
  • Gene Symbol: ZFHX3 (ENSG00000140836)
    Fold Change: 1.09
    Ensembl ID: ENSG00000140836
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.09
    Ensembl ID: ENSG00000149311
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.08
    Ensembl ID: ENSG00000134480
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.07
    Ensembl ID: ENSG00000160710
  • Gene Symbol: BNIP2 (ENSG00000140299)
    Fold Change: 1.05
    Ensembl ID: ENSG00000140299
  • Gene Symbol: ALOX5AP (ENSG00000132965)
    Fold Change: 1.05
    Ensembl ID: ENSG00000132965
  • Gene Symbol: ATP6V1B2 (ENSG00000147416)
    Fold Change: 1.05
    Ensembl ID: ENSG00000147416
  • Gene Symbol: CAT (ENSG00000121691)
    Fold Change: 1.05
    Ensembl ID: ENSG00000121691
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 1.04
    Ensembl ID: ENSG00000151914
  • Gene Symbol: ALCAM (ENSG00000170017)
    Fold Change: 1.04
    Ensembl ID: ENSG00000170017
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.04
    Ensembl ID: ENSG00000131100
  • Gene Symbol: RUNX1 (ENSG00000159216)
    Fold Change: 1.02
    Ensembl ID: ENSG00000159216
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.01
    Ensembl ID: ENSG00000004059
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.01
    Ensembl ID: ENSG00000143727
  • Gene Symbol: AP1B1 (ENSG00000100280)
    Fold Change: 1.01
    Ensembl ID: ENSG00000100280
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.01
    Ensembl ID: ENSG00000104964
  • Gene Symbol: BACH1 (ENSG00000156273)
    Fold Change: 1.01
    Ensembl ID: ENSG00000156273
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Phagocytosis**: Macrophages are capable of phagocytosing a variety of extracellular particles, including immune complexes, microorganisms, and dead cells. 2. **Antigen Presentation**: Macrophages play a crucial role in presenting antigens to T-cells, which is essential for the activation of the adaptive immune response. 3. **Differentiation from Monocytes**: Macrophages are differentiated from monocytes through a process of maturation, which involves changes in their morphology, function, and gene expression. 4. **Presence in Various Tissues**: Macrophages are present in various tissues, including the lungs, liver, and spleen, where they play a crucial role in defending against pathogens and foreign particles. 5. **Role in Immune Response**: Macrophages play a crucial role in the immune response, including the activation of T-cells, the production of cytokines, and the regulation of inflammation. **Clinical Significance** 1. **Infectious Diseases**: Macrophages play a crucial role in defending against infectious diseases, including tuberculosis, HIV, and other bacterial and viral infections. 2. **Cancer**: Macrophages have been implicated in the progression of cancer, including the promotion of tumor growth and metastasis. 3. **Autoimmune Diseases**: Macrophages have been implicated in the pathogenesis of autoimmune diseases, including rheumatoid arthritis and multiple sclerosis. 4. **Inflammatory Disorders**: Macrophages play a crucial role in the development of inflammatory disorders, including atherosclerosis and Alzheimer's disease. 5. **Immunotherapy**: Macrophages have been used as a target for immunotherapy, including the use of macrophage-targeting antibodies and vaccines. **Pathways/Ontology** Macrophages are involved in a wide range of biological processes, including: 1. **Actin Cytoskeleton**: Macrophages are involved in the regulation of the actin cytoskeleton, which is essential for their phagocytic activity. 2. **Adherens Junctions**: Macrophages are involved in the regulation of adherens junctions, which are essential for their ability to migrate and invade tissues. 3. **Apical Junction Complex**: Macrophages are involved in the regulation of the apical junction complex, which is essential for their ability to interact with other cells. 4. **B-Wich Complex**: Macrophages are involved in the regulation of the B-Wich complex, which is essential for their ability to regulate gene expression. 5. **Cell-Cell Communication**: Macrophages are involved in the regulation of cell-cell communication, including the production of cytokines and chemokines. Overall, macrophages play a crucial role in the immune system, and their dysfunction has been implicated in a wide range of diseases, including infectious diseases, cancer, autoimmune diseases, and inflammatory disorders.