Details for: CL0000235

Cell ID: CL0000235

Cell Name: macrophage

Marker Score Threshold: 1,112
(Derived using integrated single-cell and genomic data)

Description: A mononuclear phagocyte present in variety of tissues, typically differentiated from monocytes, capable of phagocytosing a variety of extracellular particulate material, including immune complexes, microorganisms, and dead cells.

Synonyms: histiocyte

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: IGHEP1 (ENSG00000253692)
    Fold Change: 8.57
    Ensembl ID: ENSG00000253692
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 2.88
    Ensembl ID: ENSG00000075624
  • Gene Symbol: FTL (ENSG00000087086)
    Fold Change: 2.87
    Ensembl ID: ENSG00000087086
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 2.86
    Ensembl ID: ENSG00000166710
  • Gene Symbol: EEF1A1 (ENSG00000156508)
    Fold Change: 2.83
    Ensembl ID: ENSG00000156508
  • Gene Symbol: FTH1 (ENSG00000167996)
    Fold Change: 2.81
    Ensembl ID: ENSG00000167996
  • Gene Symbol: H3 3B (ENSG00000132475)
    Fold Change: 2.62
    Ensembl ID: ENSG00000132475
  • Gene Symbol: MYL6 (ENSG00000092841)
    Fold Change: 2.58
    Ensembl ID: ENSG00000092841
  • Gene Symbol: FAU (ENSG00000149806)
    Fold Change: 2.58
    Ensembl ID: ENSG00000149806
  • Gene Symbol: GAPDH (ENSG00000111640)
    Fold Change: 2.56
    Ensembl ID: ENSG00000111640
  • Gene Symbol: HSP90AA1 (ENSG00000080824)
    Fold Change: 2.55
    Ensembl ID: ENSG00000080824
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 2.51
    Ensembl ID: ENSG00000172757
  • Gene Symbol: NACA (ENSG00000196531)
    Fold Change: 2.51
    Ensembl ID: ENSG00000196531
  • Gene Symbol: OAZ1 (ENSG00000104904)
    Fold Change: 2.5
    Ensembl ID: ENSG00000104904
  • Gene Symbol: RPL10A (ENSG00000198755)
    Fold Change: 2.47
    Ensembl ID: ENSG00000198755
  • Gene Symbol: HNRNPA2B1 (ENSG00000122566)
    Fold Change: 2.47
    Ensembl ID: ENSG00000122566
  • Gene Symbol: PFDN5 (ENSG00000123349)
    Fold Change: 2.45
    Ensembl ID: ENSG00000123349
  • Gene Symbol: PFN1 (ENSG00000108518)
    Fold Change: 2.44
    Ensembl ID: ENSG00000108518
  • Gene Symbol: RPSA (ENSG00000168028)
    Fold Change: 2.43
    Ensembl ID: ENSG00000168028
  • Gene Symbol: COX4I1 (ENSG00000131143)
    Fold Change: 2.42
    Ensembl ID: ENSG00000131143
  • Gene Symbol: HSP90AB1 (ENSG00000096384)
    Fold Change: 2.41
    Ensembl ID: ENSG00000096384
  • Gene Symbol: HMGB1 (ENSG00000189403)
    Fold Change: 2.4
    Ensembl ID: ENSG00000189403
  • Gene Symbol: PPIA (ENSG00000196262)
    Fold Change: 2.39
    Ensembl ID: ENSG00000196262
  • Gene Symbol: EEF1D (ENSG00000104529)
    Fold Change: 2.39
    Ensembl ID: ENSG00000104529
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 2.38
    Ensembl ID: ENSG00000019582
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.38
    Ensembl ID: ENSG00000198668
  • Gene Symbol: COX7C (ENSG00000127184)
    Fold Change: 2.37
    Ensembl ID: ENSG00000127184
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.35
    Ensembl ID: ENSG00000145741
  • Gene Symbol: EEF1B2 (ENSG00000114942)
    Fold Change: 2.34
    Ensembl ID: ENSG00000114942
  • Gene Symbol: H3 3A (ENSG00000163041)
    Fold Change: 2.33
    Ensembl ID: ENSG00000163041
  • Gene Symbol: CST3 (ENSG00000101439)
    Fold Change: 2.32
    Ensembl ID: ENSG00000101439
  • Gene Symbol: EEF2 (ENSG00000167658)
    Fold Change: 2.31
    Ensembl ID: ENSG00000167658
  • Gene Symbol: FOS (ENSG00000170345)
    Fold Change: 2.28
    Ensembl ID: ENSG00000170345
  • Gene Symbol: YBX1 (ENSG00000065978)
    Fold Change: 2.27
    Ensembl ID: ENSG00000065978
  • Gene Symbol: HTR1E (ENSG00000168830)
    Fold Change: 2.24
    Ensembl ID: ENSG00000168830
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 2.23
    Ensembl ID: ENSG00000135404
  • Gene Symbol: NPM1 (ENSG00000181163)
    Fold Change: 2.22
    Ensembl ID: ENSG00000181163
  • Gene Symbol: OPCML (ENSG00000183715)
    Fold Change: 2.21
    Ensembl ID: ENSG00000183715
  • Gene Symbol: HSPA8 (ENSG00000109971)
    Fold Change: 2.21
    Ensembl ID: ENSG00000109971
  • Gene Symbol: NDUFA4 (ENSG00000189043)
    Fold Change: 2.21
    Ensembl ID: ENSG00000189043
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.21
    Ensembl ID: ENSG00000067560
  • Gene Symbol: JUNB (ENSG00000171223)
    Fold Change: 2.18
    Ensembl ID: ENSG00000171223
  • Gene Symbol: COX6C (ENSG00000164919)
    Fold Change: 2.17
    Ensembl ID: ENSG00000164919
  • Gene Symbol: COX6B1 (ENSG00000126267)
    Fold Change: 2.17
    Ensembl ID: ENSG00000126267
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 2.16
    Ensembl ID: ENSG00000169100
  • Gene Symbol: HINT1 (ENSG00000169567)
    Fold Change: 2.13
    Ensembl ID: ENSG00000169567
  • Gene Symbol: GNAS (ENSG00000087460)
    Fold Change: 2.12
    Ensembl ID: ENSG00000087460
  • Gene Symbol: DUSP1 (ENSG00000120129)
    Fold Change: 2.12
    Ensembl ID: ENSG00000120129
  • Gene Symbol: COX5B (ENSG00000135940)
    Fold Change: 2.12
    Ensembl ID: ENSG00000135940
  • Gene Symbol: HNRNPK (ENSG00000165119)
    Fold Change: 2.1
    Ensembl ID: ENSG00000165119
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 2.1
    Ensembl ID: ENSG00000070831
  • Gene Symbol: KLF6 (ENSG00000067082)
    Fold Change: 2.1
    Ensembl ID: ENSG00000067082
  • Gene Symbol: CYBA (ENSG00000051523)
    Fold Change: 2.09
    Ensembl ID: ENSG00000051523
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.09
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.09
    Ensembl ID: ENSG00000185650
  • Gene Symbol: HNRNPC (ENSG00000092199)
    Fold Change: 2.09
    Ensembl ID: ENSG00000092199
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 2.07
    Ensembl ID: ENSG00000077549
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 2.06
    Ensembl ID: ENSG00000099622
  • Gene Symbol: DDX5 (ENSG00000108654)
    Fold Change: 2.05
    Ensembl ID: ENSG00000108654
  • Gene Symbol: COX7A2 (ENSG00000112695)
    Fold Change: 2.05
    Ensembl ID: ENSG00000112695
  • Gene Symbol: GPX4 (ENSG00000167468)
    Fold Change: 2.05
    Ensembl ID: ENSG00000167468
  • Gene Symbol: CTSB (ENSG00000164733)
    Fold Change: 2.04
    Ensembl ID: ENSG00000164733
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.02
    Ensembl ID: ENSG00000184009
  • Gene Symbol: JUN (ENSG00000177606)
    Fold Change: 2.02
    Ensembl ID: ENSG00000177606
  • Gene Symbol: COX1 (ENSG00000198804)
    Fold Change: 2.02
    Ensembl ID: ENSG00000198804
  • Gene Symbol: NFKBIA (ENSG00000100906)
    Fold Change: 2.01
    Ensembl ID: ENSG00000100906
  • Gene Symbol: SLC25A3 (ENSG00000075415)
    Fold Change: 2.01
    Ensembl ID: ENSG00000075415
  • Gene Symbol: COX6A1 (ENSG00000111775)
    Fold Change: 2
    Ensembl ID: ENSG00000111775
  • Gene Symbol: COX2 (ENSG00000198712)
    Fold Change: 2
    Ensembl ID: ENSG00000198712
  • Gene Symbol: ENO1 (ENSG00000074800)
    Fold Change: 2
    Ensembl ID: ENSG00000074800
  • Gene Symbol: HLA B (ENSG00000234745)
    Fold Change: 2
    Ensembl ID: ENSG00000234745
  • Gene Symbol: PRDX1 (ENSG00000117450)
    Fold Change: 2
    Ensembl ID: ENSG00000117450
  • Gene Symbol: PCBP2 (ENSG00000197111)
    Fold Change: 1.99
    Ensembl ID: ENSG00000197111
  • Gene Symbol: COX3 (ENSG00000198938)
    Fold Change: 1.99
    Ensembl ID: ENSG00000198938
  • Gene Symbol: HNRNPU (ENSG00000153187)
    Fold Change: 1.99
    Ensembl ID: ENSG00000153187
  • Gene Symbol: COX8A (ENSG00000176340)
    Fold Change: 1.98
    Ensembl ID: ENSG00000176340
  • Gene Symbol: GLUL (ENSG00000135821)
    Fold Change: 1.97
    Ensembl ID: ENSG00000135821
  • Gene Symbol: HLA A (ENSG00000206503)
    Fold Change: 1.97
    Ensembl ID: ENSG00000206503
  • Gene Symbol: EIF4G2 (ENSG00000110321)
    Fold Change: 1.96
    Ensembl ID: ENSG00000110321
  • Gene Symbol: ATP6 (ENSG00000198899)
    Fold Change: 1.96
    Ensembl ID: ENSG00000198899
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.95
    Ensembl ID: ENSG00000179218
  • Gene Symbol: PPIB (ENSG00000166794)
    Fold Change: 1.95
    Ensembl ID: ENSG00000166794
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.94
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ND3 (ENSG00000198840)
    Fold Change: 1.94
    Ensembl ID: ENSG00000198840
  • Gene Symbol: HLA C (ENSG00000204525)
    Fold Change: 1.94
    Ensembl ID: ENSG00000204525
  • Gene Symbol: ND4 (ENSG00000198886)
    Fold Change: 1.94
    Ensembl ID: ENSG00000198886
  • Gene Symbol: GUK1 (ENSG00000143774)
    Fold Change: 1.93
    Ensembl ID: ENSG00000143774
  • Gene Symbol: CSTB (ENSG00000160213)
    Fold Change: 1.93
    Ensembl ID: ENSG00000160213
  • Gene Symbol: FUS (ENSG00000089280)
    Fold Change: 1.93
    Ensembl ID: ENSG00000089280
  • Gene Symbol: NDUFA1 (ENSG00000125356)
    Fold Change: 1.91
    Ensembl ID: ENSG00000125356
  • Gene Symbol: MBNL1 (ENSG00000152601)
    Fold Change: 1.91
    Ensembl ID: ENSG00000152601
  • Gene Symbol: NDUFS5 (ENSG00000168653)
    Fold Change: 1.89
    Ensembl ID: ENSG00000168653
  • Gene Symbol: JUND (ENSG00000130522)
    Fold Change: 1.89
    Ensembl ID: ENSG00000130522
  • Gene Symbol: NDUFB2 (ENSG00000090266)
    Fold Change: 1.88
    Ensembl ID: ENSG00000090266
  • Gene Symbol: PDIA3 (ENSG00000167004)
    Fold Change: 1.88
    Ensembl ID: ENSG00000167004
  • Gene Symbol: NAP1L1 (ENSG00000187109)
    Fold Change: 1.88
    Ensembl ID: ENSG00000187109
  • Gene Symbol: CYTB (ENSG00000198727)
    Fold Change: 1.87
    Ensembl ID: ENSG00000198727
  • Gene Symbol: HSPB1 (ENSG00000106211)
    Fold Change: 1.87
    Ensembl ID: ENSG00000106211
  • Gene Symbol: PKM (ENSG00000067225)
    Fold Change: 1.87
    Ensembl ID: ENSG00000067225
  • Gene Symbol: DNAJA1 (ENSG00000086061)
    Fold Change: 1.87
    Ensembl ID: ENSG00000086061

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in macrophage cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in macrophage cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.
**Key Characteristics** * Mononuclear phagocyte * Present in various tissues * Differentiated from monocytes * Capable of phagocytosing extracellular particulate material * Engulf and digest foreign particles and cellular debris * Involved in various cellular processes, including: + Cell signaling + Protein degradation + Immune responses * Characterized by their ability to express specific genes and proteins, including: + IGHEP1 gene + ACTB gene + FTL gene + B2M gene **Clinical Significance** Macrophages play a crucial role in the immune system and are involved in various diseases, including: * Infections: Macrophages are involved in the defense against infections, including bacterial, viral, and fungal infections. * Autoimmune diseases: Macrophages can contribute to autoimmune diseases by presenting antigens to T cells and promoting inflammatory responses. * Cancer: Macrophages can promote tumor growth and metastasis by supporting angiogenesis and suppressing immune responses. * Neurological disorders: Macrophages are involved in the pathogenesis of various neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. * Cardiovascular disease: Macrophages can contribute to the development of atherosclerosis by presenting antigens to T cells and promoting inflammatory responses. Overall, macrophages are an essential component of the immune system and play a critical role in maintaining immune homeostasis. Understanding the biology of macrophages is essential for the development of effective therapies for various diseases.