Details for: HBG2

Gene ID: 3048

Symbol: HBG2

Ensembl ID: ENSG00000196565

Description: hemoglobin subunit gamma 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 55.5110
    Cell Significance Index: -14.0800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 26.9448
    Cell Significance Index: -13.8600
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 26.6482
    Cell Significance Index: -4.1500
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 22.8930
    Cell Significance Index: 385.0500
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 15.9781
    Cell Significance Index: 45.7900
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 8.7951
    Cell Significance Index: 76.0800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 6.7338
    Cell Significance Index: -8.3000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 4.9262
    Cell Significance Index: 40.1700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.5149
    Cell Significance Index: -13.8700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 2.3300
    Cell Significance Index: 48.7700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.1678
    Cell Significance Index: 58.0900
  • Cell Name: chondroblast (CL0000058)
    Fold Change: 1.6456
    Cell Significance Index: 9.6600
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.6234
    Cell Significance Index: 9.5900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.5812
    Cell Significance Index: 17.1900
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 1.2813
    Cell Significance Index: 5.4700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.2155
    Cell Significance Index: 9.7100
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.0865
    Cell Significance Index: 12.3000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.7093
    Cell Significance Index: 43.6000
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 0.6348
    Cell Significance Index: 2.8100
  • Cell Name: reticulocyte (CL0000558)
    Fold Change: 0.6102
    Cell Significance Index: 3.2100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.4455
    Cell Significance Index: 5.7100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.4253
    Cell Significance Index: 10.6100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4121
    Cell Significance Index: 14.3200
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.3549
    Cell Significance Index: 2.8800
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.3381
    Cell Significance Index: 3.6700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.2956
    Cell Significance Index: 5.7700
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: 0.2073
    Cell Significance Index: 1.2700
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 0.1905
    Cell Significance Index: 2.5900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1332
    Cell Significance Index: 2.2300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.1205
    Cell Significance Index: 3.5500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.1120
    Cell Significance Index: 2.6900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0927
    Cell Significance Index: 0.5600
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.0909
    Cell Significance Index: 1.3300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0837
    Cell Significance Index: 2.2400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0497
    Cell Significance Index: 0.5200
  • Cell Name: articular chondrocyte (CL1001607)
    Fold Change: 0.0480
    Cell Significance Index: 0.2600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0445
    Cell Significance Index: 12.8200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0395
    Cell Significance Index: 1.1100
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.0131
    Cell Significance Index: 0.1300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0056
    Cell Significance Index: 0.1500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0119
    Cell Significance Index: -1.5300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0133
    Cell Significance Index: -10.0700
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: -0.0160
    Cell Significance Index: -0.1200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0183
    Cell Significance Index: -13.5400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0207
    Cell Significance Index: -15.1900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0213
    Cell Significance Index: -0.9200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0217
    Cell Significance Index: -13.5700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0231
    Cell Significance Index: -12.6000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0236
    Cell Significance Index: -13.3200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0355
    Cell Significance Index: -6.0600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0380
    Cell Significance Index: -13.6200
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.0385
    Cell Significance Index: -0.2800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0642
    Cell Significance Index: -13.5200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0676
    Cell Significance Index: -13.5700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0701
    Cell Significance Index: -12.6300
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.0773
    Cell Significance Index: -0.3700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0929
    Cell Significance Index: -12.7600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0981
    Cell Significance Index: -11.2400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1054
    Cell Significance Index: -12.9600
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.1061
    Cell Significance Index: -0.4900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1097
    Cell Significance Index: -2.8200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1167
    Cell Significance Index: -11.9200
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.1307
    Cell Significance Index: -1.2600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1378
    Cell Significance Index: -3.7500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1591
    Cell Significance Index: -5.2100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1592
    Cell Significance Index: -2.2800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1856
    Cell Significance Index: -3.1800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1901
    Cell Significance Index: -14.5900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1922
    Cell Significance Index: -15.2200
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.1926
    Cell Significance Index: -2.7700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2032
    Cell Significance Index: -3.0000
  • Cell Name: peridermal cell (CL0000078)
    Fold Change: -0.2052
    Cell Significance Index: -1.2800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2080
    Cell Significance Index: -9.7000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2136
    Cell Significance Index: -13.7800
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: -0.2155
    Cell Significance Index: -1.6800
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.2183
    Cell Significance Index: -3.0600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2185
    Cell Significance Index: -6.9600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2365
    Cell Significance Index: -3.4900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2387
    Cell Significance Index: -13.4000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.2435
    Cell Significance Index: -1.6500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2456
    Cell Significance Index: -12.7600
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.2497
    Cell Significance Index: -2.7200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2604
    Cell Significance Index: -13.6700
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2665
    Cell Significance Index: -6.7900
  • Cell Name: intratelencephalic-projecting glutamatergic cortical neuron (CL4023008)
    Fold Change: -0.2908
    Cell Significance Index: -2.9900
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.2914
    Cell Significance Index: -2.9400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2928
    Cell Significance Index: -7.7000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3014
    Cell Significance Index: -14.1700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3160
    Cell Significance Index: -11.0700
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.3195
    Cell Significance Index: -3.8100
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.3252
    Cell Significance Index: -4.6700
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: -0.3374
    Cell Significance Index: -3.7200
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.3395
    Cell Significance Index: -3.7500
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.3491
    Cell Significance Index: -3.8100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3555
    Cell Significance Index: -13.0500
  • Cell Name: medial ganglionic eminence derived GABAergic cortical interneuron (CL4023069)
    Fold Change: -0.3600
    Cell Significance Index: -3.4000
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.3677
    Cell Significance Index: -4.2900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3712
    Cell Significance Index: -10.6400
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.3821
    Cell Significance Index: -5.4800
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.3895
    Cell Significance Index: -3.7000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** * HBG2 is a small, four-alpha and four-gamma subunit globin protein that is encoded by the HBG2 gene. * It is a critical component of hemoglobin, the oxygen-transporting protein in red blood cells. * The gamma-2 subunit is unique in that it is the only subunit that is not encoded by a separate gene; instead, it is encoded by the HBG2 gene. * HBG2 is expressed in various tissues, including the liver, skeletal muscle, and hematopoietic cells, where it plays a role in oxygen transport and delivery. **Pathways and Functions:** * **Oxygen Transport:** HBG2 plays a critical role in maintaining the balance of oxygen delivery to tissues and organs throughout the body. It is involved in the oxygen-transporting function of hemoglobin, which is essential for delivering oxygen to tissues and organs. * **Carbon Dioxide Transport:** HBG2 is also involved in the transport of carbon dioxide from tissues to the lungs, where it is exhaled. * **Cellular Oxidant Detoxification:** HBG2 has antioxidant properties, helping to protect cells from oxidative stress and damage. * **Haptoglobin-Hemoglobin Complex:** HBG2 is involved in the formation of the haptoglobin-hemoglobin complex, which helps to remove free hemoglobin from the circulation and prevent oxidative damage. * **Protein Binding:** HBG2 has a high affinity for binding to various proteins, including haptoglobin, hemoglobin alpha, and other globin proteins. **Clinical Significance:** * **Anemia:** Mutations in the HBG2 gene can lead to various types of anemia, including beta-thalassemia and alpha-thalassemia. * **Hemoglobinopathies:** HBG2 is also involved in the pathogenesis of hemoglobinopathies, such as sickle cell disease and sickle cell trait. * **Oxygen Delivery:** Impaired HBG2 function can lead to impaired oxygen delivery to tissues and organs, resulting in various clinical manifestations, including fatigue, weakness, and shortness of breath. * **Cardiovascular Disease:** HBG2 has been implicated in the development of cardiovascular disease, particularly in patients with sickle cell disease and other hemoglobinopathies. In conclusion, HBG2 plays a vital role in maintaining the balance of oxygen delivery to tissues and organs throughout the body. Its dysregulation can lead to various clinical manifestations, including anemia, hemoglobinopathies, and cardiovascular disease. Further research is needed to fully understand the mechanisms by which HBG2 influences human physiology and to develop effective therapeutic strategies for the treatment of HBG2-related disorders.

Genular Protein ID: 681510906

Symbol: HBG2_HUMAN

Name: Hemoglobin subunit gamma-2

UniProtKB Accession Codes:

P69892 A8MZE0 P02096 P62027 Q14491 Q68NH9 Q96FH6 Q96FH7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEBI 4 ChiTaRS 1 ComplexPortal 2 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7438203

Title: Human fetal G gamma- and A gamma-globin genes: complete nucleotide sequences suggest that DNA can be exchanged between these duplicated genes.

PubMed ID: 7438203

DOI: 10.1016/0092-8674(80)90426-2

PubMed ID: 7250702

Title: Nucleotide sequence of human G gamma globin messenger RNA.

PubMed ID: 7250702

DOI: 10.1016/0378-1119(80)90103-1

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14087393

Title: The amino acid sequence of the gamma chain of human fetal hemoglobin.

PubMed ID: 14087393

DOI: 10.1021/bi00905a016

PubMed ID: 2581851

Title: Cloning specific complete polyadenylylated 3'-terminal cDNA segments.

PubMed ID: 2581851

DOI: 10.1016/0378-1119(85)90093-9

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 881729

Title: Structure of human foetal deoxyhaemoglobin.

PubMed ID: 881729

DOI: 10.1016/s0022-2836(77)80158-7

PubMed ID: 5554303

Title: Human fetal hemoglobin F 1. Acetylation status.

PubMed ID: 5554303

DOI: 10.1016/s0021-9258(18)62282-3

PubMed ID: 5792729

Title: Haemoglobin F(Malta): a new foetal haemoglobin variant with a high incidence in Maltese infants.

PubMed ID: 5792729

DOI: 10.1038/223311a0

PubMed ID: 4429671

Title: Haemoglobin F Auckland G gamma 7 Asp leads to Asn: further evidence for multiple genes for the gamma chain.

PubMed ID: 4429671

DOI: 10.1016/0005-2795(74)90004-x

PubMed ID: 4846278

Title: Haemoglobin F Port Royal (alpha2G gamma2 125 Glu leads to Ala).

PubMed ID: 4846278

DOI: 10.1111/j.1365-2141.1974.tb06798.x

PubMed ID: 4837284

Title: Haemoglobin F Malaysia: alpha 2, gamma 2 1(NA1) glycine-->cysteine; 136 glycine.

PubMed ID: 4837284

DOI: 10.1136/jmg.11.1.25

PubMed ID: 1127124

Title: A new cause of haemolytic anaemia in the newborn. A description of an unstable fetal haemoglobin: F Poole, alpha2-G-gamma2 130 tryptophan yields glycine.

PubMed ID: 1127124

DOI: 10.1136/jcp.28.4.317

PubMed ID: 836882

Title: Haemoglobin F Melbourne Ggamma 16 Gly leads to Arg and haemoglobin F carlton Ggamma 121 Glu leads to Lys. Further evidence for varied activity of gamma-chain genes.

PubMed ID: 836882

DOI: 10.1016/0005-2795(77)90020-4

PubMed ID: 6172403

Title: Hb F-Meinohama or alpha 2 gamma 2 (5 Glu replaced by Gly; 75 Ile; 136 Gly).

PubMed ID: 6172403

DOI: 10.3109/03630268108991687

PubMed ID: 6814491

Title: Hemoglobin F Lodz (G gamma I 44 Ser replaced by Arg). A newly identified variant from an American infant of Polish descent.

PubMed ID: 6814491

DOI: 10.1016/0167-4838(82)90353-3

PubMed ID: 6186522

Title: Hb F Kingston (G gamma 55 [D6] Met leads to Arg).

PubMed ID: 6186522

DOI: 10.1016/0014-5793(82)81307-0

PubMed ID: 6186635

Title: Hemoglobin F-Caltech: alpha 2 G gamma 2 120Lys replaced by Gln.

PubMed ID: 6186635

DOI: 10.3109/03630268209046451

PubMed ID: 6186636

Title: Hb F-Columbus-Ga or alpha 2 G gamma 2 94(FGl) Asp replaced by Asn.

PubMed ID: 6186636

DOI: 10.3109/03630268209046452

PubMed ID: 6192110

Title: Hb F-Kennestone or alpha 2G gamma 2 (EF1)77 His leads to Arg observed in a Caucasian baby.

PubMed ID: 6192110

DOI: 10.3109/03630268309048656

PubMed ID: 6206897

Title: Hb F-La Grange or alpha 2 gamma 2 101(G3)Glu-->Lys; 75Ile; 136Gly: a high oxygen affinity fetal hemoglobin variant observed in a Caucasian newborn.

PubMed ID: 6206897

DOI: 10.1016/0167-4838(84)90208-5

PubMed ID: 2579547

Title: -G gamma A gamma-thalassemia and gamma-chain variants in Chinese newborn babies.

PubMed ID: 2579547

DOI: 10.1002/ajh.2830180303

PubMed ID: 2581919

Title: Hb F-Tokyo or alpha 2G gamma 2 34(B16)Val-->Ile, a silent gamma chain variant detected by reverse phase high performance liquid chromatography.

PubMed ID: 2581919

DOI: 10.3109/03630268508996979

PubMed ID: 2420748

Title: Hb F-Urumqi G gamma I22(B4)Asp-->Gly: a new fetal hemoglobin variant found in a Uygur baby.

PubMed ID: 2420748

DOI: 10.3109/03630268609072467

PubMed ID: 2435680

Title: Hb F-Albaicin or G gamma 8(A5)Lys-->Glu or Gln.

PubMed ID: 2435680

DOI: 10.3109/03630268609036569

PubMed ID: 3120456

Title: Neonatal screening and mass-spectrometric analysis of hemoglobin variants in Japan.

PubMed ID: 3120456

DOI: 10.1159/000205857

PubMed ID: 2442122

Title: Hb F-Oakland or alpha 2G gamma I2(26)(B8)Glu-->Lys.

PubMed ID: 2442122

DOI: 10.3109/03630268709005796

PubMed ID: 2442123

Title: Hb F-Clarke or alpha 2G gamma 2(65)(E9)Lys-->Asn.

PubMed ID: 2442123

DOI: 10.3109/03630268709005797

PubMed ID: 2459082

Title: Hb F-Granada or alpha 2G gamma (2)22(B4)Asp-->Val: a new human fetal hemoglobin variant.

PubMed ID: 2459082

DOI: 10.3109/03630268808998041

PubMed ID: 2459083

Title: Hb F-Austell or alpha 2G gamma (2)40(C6)Arg-->Lys.

PubMed ID: 2459083

DOI: 10.3109/03630268808998042

PubMed ID: 2483933

Title: Hb F-M-Osaka or alpha 2G gamma 2(63)(E7)His-->Tyr in a Caucasian male infant.

PubMed ID: 2483933

DOI: 10.3109/03630268908998852

PubMed ID: 2470017

Title: Mutant fetal hemoglobin causing cyanosis in a newborn.

PubMed ID: 2470017

PubMed ID: 1703138

Title: Hb F-Brooklyn or alpha 2G gamma 2(66)(E10)Lys-->Gln.

PubMed ID: 1703138

DOI: 10.3109/03630269009046963

PubMed ID: 1703139

Title: Hb F-Onoda or alpha 2G gamma 2(146)(HC3)His-->Tyr, a newly discovered fetal hemoglobin variant in a Japanese newborn.

PubMed ID: 1703139

DOI: 10.3109/03630269009046964

PubMed ID: 1706691

Title: Hb F-Catalonia or alpha 2G gamma(2)15(A12)Trp-->Arg.

PubMed ID: 1706691

DOI: 10.3109/03630269009005804

PubMed ID: 1714434

Title: Hb F-Charlotte, an A gamma variant with a threonine residue in position gamma 75 and a glycine residue in position gamma 136.

PubMed ID: 1714434

DOI: 10.3109/03630269009046970

PubMed ID: 1726095

Title: Hb F-Cosenza or G gamma 25(B7)Gly-->Glu: a new fast-moving fetal hemoglobin variant.

PubMed ID: 1726095

DOI: 10.3109/03630269109027898

PubMed ID: 8144355

Title: Hb F-Saskatoon or alpha 2G gamma (2)21(B3)Glu-->Lys observed in a North American indian newborn.

PubMed ID: 8144355

DOI: 10.3109/03630269309043495

PubMed ID: 7713741

Title: Hb F-Macedonia-II [G gamma 104(G6)Lys-->Asn]: a new gamma chain variant.

PubMed ID: 7713741

DOI: 10.3109/03630269409045769

PubMed ID: 7741137

Title: Hemoglobin F-Cincinnati, alpha 2G gamma 2 41(C7) Phe-->Ser in a newborn with cyanosis.

PubMed ID: 7741137

DOI: 10.1002/ajh.2830490108

PubMed ID: 7558873

Title: Two fetal hemoglobin variants affecting the same residue: Hb F-Emirates [G gamma 59(E3)Lys-->Glu] and Hb F-Sacromonte [G gamma 59(E3)Lys-->Gln].

PubMed ID: 7558873

DOI: 10.3109/03630269509036937

PubMed ID: 8718700

Title: Hb F-Veleta or alpha 2 G gamma(2)40(C6)Arg-->Gly.

PubMed ID: 8718700

PubMed ID: 8718701

Title: The G gamma T chain (G gamma 75 Thr; 136 Gly) in Hb F-Charlotte is the product of an A gamma gene with a limited gene conversion and that in Hb F-Waynesboro of a mutated G gamma gene.

PubMed ID: 8718701

DOI: 10.3109/03630269509005834

PubMed ID: 8566966

Title: HbF-Lesvos: an HbF variant due to a novel G gamma mutation (G gamma 75 ATA-->ACA) detected in a Greek family.

PubMed ID: 8566966

DOI: 10.1007/bf02265278

PubMed ID: 10722114

Title: A new, electrophoretically silent, fetal hemoglobin variant: Hb F-Calabria Ggamma118(GH1)Phe-->Leu.

PubMed ID: 10722114

DOI: 10.3109/03630260009002272

PubMed ID: 10722115

Title: Two new Ggamma chain variants: Hb F-Clamart [gamma17(A14)Lys-->Asn] and Hb F-Ouled Rabah [gamma19(B1)Asn-->Lys].

PubMed ID: 10722115

DOI: 10.3109/03630260009002273

PubMed ID: 11791877

Title: A new Ggamma chain variant: Hb F-Coignieres [gamma75(E19)Ile-->Val].

PubMed ID: 11791877

DOI: 10.1081/hem-100107881

PubMed ID: 15645283

Title: Severe hereditary haemolytic anaemia in a Caucasian newborn: a new fetal haemoglobin variant Hb F-Bonheiden ((G)gamma 38(C4) Thr-->Pro).

PubMed ID: 15645283

DOI: 10.1007/s00431-004-1614-7

PubMed ID: 16370494

Title: A new G(gamma) chain variant: Hb F-Bron [gamma20(B2)Val-->Ala].

PubMed ID: 16370494

DOI: 10.1080/03630260500312725

PubMed ID: 19065339

Title: Neonatal cyanosis due to a novel fetal hemoglobin: Hb F-Circleville [Ggamma63(E7)His-->Leu, CAT>CTT].

PubMed ID: 19065339

DOI: 10.1080/03630260802507915

PubMed ID: 21561349

Title: A hemoglobin variant associated with neonatal cyanosis and anemia.

PubMed ID: 21561349

DOI: 10.1056/nejmoa1013579

PubMed ID: 24502349

Title: A new (G)gamma-globin variant causing low oxygen affinity: Hb F-Brugine/Feldkirch [(G)gamma105(G7)Leu?His; HBG2: c.317T>A].

PubMed ID: 24502349

DOI: 10.3109/03630269.2013.870079

Sequence Information:

  • Length: 147
  • Mass: 16126
  • Checksum: 8FCDC4441B416DDE
  • Sequence:
    • MGHFTEEDKA TITSLWGKVN VEDAGGETLG RLLVVYPWTQ RFFDSFGNLS SASAIMGNPK 
VKAHGKKVLT SLGDAIKHLD DLKGTFAQLS ELHCDKLHVD PENFKLLGNV LVTVLAIHFG 
KEFTPEVQAS WQKMVTGVAS ALSSRYH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.