Details for: CL0000388

Cell ID: CL0000388

Cell Name: tendon cell

Marker Score Threshold: 246
(Derived using integrated single-cell and genomic data)

Description: An elongated fibrocyte that is part of a tendon. The cytoplasm is stretched between the collagen fibres of the tendon. They have a central cell nucleus with a prominent nucleolus. Tendon cells have a well-developed rough endoplasmic reticulum and they are responsible for synthesis and turnover of tendon fibres and ground substance.

Synonyms: muscle attachment cell, tenocyte

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.9
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.63
    Ensembl ID: ENSG00000166710
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 3.14
    Ensembl ID: ENSG00000172757
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 3.12
    Ensembl ID: ENSG00000184009
  • Gene Symbol: CIRBP (ENSG00000099622)
    Fold Change: 2.92
    Ensembl ID: ENSG00000099622
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.75
    Ensembl ID: ENSG00000135390
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 2.72
    Ensembl ID: ENSG00000145741
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.72
    Ensembl ID: ENSG00000198668
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.59
    Ensembl ID: ENSG00000124172
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.56
    Ensembl ID: ENSG00000133639
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 2.47
    Ensembl ID: ENSG00000070831
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.46
    Ensembl ID: ENSG00000067560
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 2.4
    Ensembl ID: ENSG00000077549
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 2.35
    Ensembl ID: ENSG00000019582
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.18
    Ensembl ID: ENSG00000143933
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 2.1
    Ensembl ID: ENSG00000179218
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 2.09
    Ensembl ID: ENSG00000135404
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.07
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.07
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.04
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.03
    Ensembl ID: ENSG00000110955
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 2.03
    Ensembl ID: ENSG00000122545
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 1.98
    Ensembl ID: ENSG00000154723
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.98
    Ensembl ID: ENSG00000172270
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.96
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 1.94
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.91
    Ensembl ID: ENSG00000152234
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 1.89
    Ensembl ID: ENSG00000134825
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.86
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 1.82
    Ensembl ID: ENSG00000185650
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 1.82
    Ensembl ID: ENSG00000152518
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.81
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.79
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.76
    Ensembl ID: ENSG00000165629
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.74
    Ensembl ID: ENSG00000116489
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 1.72
    Ensembl ID: ENSG00000111348
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.71
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.67
    Ensembl ID: ENSG00000130402
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.65
    Ensembl ID: ENSG00000198898
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.65
    Ensembl ID: ENSG00000153113
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 1.62
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.62
    Ensembl ID: ENSG00000116459
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.59
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.59
    Ensembl ID: ENSG00000163399
  • Gene Symbol: CHD2 (ENSG00000173575)
    Fold Change: 1.59
    Ensembl ID: ENSG00000173575
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.58
    Ensembl ID: ENSG00000128272
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.53
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.53
    Ensembl ID: ENSG00000241837
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.51
    Ensembl ID: ENSG00000196776
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.49
    Ensembl ID: ENSG00000104964
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.48
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.48
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.47
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.44
    Ensembl ID: ENSG00000168374
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.42
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.39
    Ensembl ID: ENSG00000072778
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.39
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ADAR (ENSG00000160710)
    Fold Change: 1.37
    Ensembl ID: ENSG00000160710
  • Gene Symbol: CCT6A (ENSG00000146731)
    Fold Change: 1.36
    Ensembl ID: ENSG00000146731
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 1.35
    Ensembl ID: ENSG00000130303
  • Gene Symbol: CCND3 (ENSG00000112576)
    Fold Change: 1.35
    Ensembl ID: ENSG00000112576
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.35
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ACP1 (ENSG00000143727)
    Fold Change: 1.35
    Ensembl ID: ENSG00000143727
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.34
    Ensembl ID: ENSG00000100823
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.34
    Ensembl ID: ENSG00000087088
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.34
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.33
    Ensembl ID: ENSG00000159199
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.31
    Ensembl ID: ENSG00000123505
  • Gene Symbol: CCNH (ENSG00000134480)
    Fold Change: 1.3
    Ensembl ID: ENSG00000134480
  • Gene Symbol: PARP1 (ENSG00000143799)
    Fold Change: 1.3
    Ensembl ID: ENSG00000143799
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.26
    Ensembl ID: ENSG00000115307
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 1.22
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 1.2
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.2
    Ensembl ID: ENSG00000004059
  • Gene Symbol: CHD1 (ENSG00000153922)
    Fold Change: 1.2
    Ensembl ID: ENSG00000153922
  • Gene Symbol: FOXN3 (ENSG00000053254)
    Fold Change: 1.19
    Ensembl ID: ENSG00000053254
  • Gene Symbol: CTSC (ENSG00000109861)
    Fold Change: 1.19
    Ensembl ID: ENSG00000109861
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 1.18
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.18
    Ensembl ID: ENSG00000149311
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 1.17
    Ensembl ID: ENSG00000100300
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 1.17
    Ensembl ID: ENSG00000026508
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.16
    Ensembl ID: ENSG00000084234
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.16
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.12
    Ensembl ID: ENSG00000177556
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 1.12
    Ensembl ID: ENSG00000087274
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.12
    Ensembl ID: ENSG00000142192
  • Gene Symbol: CHD4 (ENSG00000111642)
    Fold Change: 1.12
    Ensembl ID: ENSG00000111642
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 1.11
    Ensembl ID: ENSG00000177105
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.1
    Ensembl ID: ENSG00000137845
  • Gene Symbol: CAPNS1 (ENSG00000126247)
    Fold Change: 1.09
    Ensembl ID: ENSG00000126247
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.09
    Ensembl ID: ENSG00000131100
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.07
    Ensembl ID: ENSG00000164615
  • Gene Symbol: LYST (ENSG00000143669)
    Fold Change: 1.06
    Ensembl ID: ENSG00000143669
  • Gene Symbol: PTTG1IP (ENSG00000183255)
    Fold Change: 1.06
    Ensembl ID: ENSG00000183255
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.06
    Ensembl ID: ENSG00000107262
  • Gene Symbol: BNIP2 (ENSG00000140299)
    Fold Change: 1.04
    Ensembl ID: ENSG00000140299
  • Gene Symbol: AK2 (ENSG00000004455)
    Fold Change: 1.02
    Ensembl ID: ENSG00000004455
  • Gene Symbol: VPS51 (ENSG00000149823)
    Fold Change: 1.02
    Ensembl ID: ENSG00000149823
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1
    Ensembl ID: ENSG00000148700
  • Gene Symbol: CENPC (ENSG00000145241)
    Fold Change: 1
    Ensembl ID: ENSG00000145241
Hovered Details

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Hovered Details

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**Key Characteristics** * **Cell shape**: Tendon cells are elongated fibrocytes with a central cell nucleus and a prominent nucleolus. * **Cytoplasmic structure**: The cytoplasm is stretched between the collagen fibers of the tendon, indicating a high degree of contractility. * **Rough endoplasmic reticulum**: Tendon cells have a well-developed rough endoplasmic reticulum, which is responsible for protein synthesis and folding. * **Gene expression**: Tendon cells express genes involved in the synthesis and turnover of collagen fibers and ground substance, as well as genes involved in cell-cell communication and regulation of the actin cytoskeleton. * **Cell-cell interactions**: Tendon cells interact with other cells and extracellular matrix components to maintain tendon structure and function. **Clinical Significance** Tendon cells play a crucial role in tendon health and disease. Abnormalities in tendon cell function and structure have been implicated in various musculoskeletal disorders, including tendonitis, tendinopathy, and tendon rupture. Understanding the biology of tendon cells is essential for the development of novel therapeutic strategies for tendon-related diseases. Some potential clinical applications of tendon cell biology include: * **Tendon repair and regeneration**: Tendon cells have the ability to synthesize and produce new collagen fibers, which could be harnessed to develop novel therapies for tendon repair and regeneration. * **Tendon disease treatment**: Understanding the biology of tendon cells could lead to the development of novel treatments for tendon-related diseases, such as tendonitis and tendinopathy. * **Musculoskeletal health and disease prevention**: Tendon cells play a crucial role in maintaining muscle and tendon function, and understanding their biology could lead to the development of novel strategies for preventing and treating musculoskeletal disorders. Overall, the study of tendon cells is essential for understanding the biology of tendons and developing novel therapeutic strategies for tendon-related diseases.