Details for: FAP

Gene ID: 2191

Symbol: FAP

Ensembl ID: ENSG00000078098

Description: fibroblast activation protein alpha

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 2.33
    Marker Score: 3197
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.71
    Marker Score: 688
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.61
    Marker Score: 6943
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168726
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.43
    Marker Score: 905.5
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.41
    Marker Score: 15827
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 866
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.27
    Marker Score: 2451
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.25
    Marker Score: 281
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.17
    Marker Score: 484
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4808
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.1
    Marker Score: 1332
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.04
    Marker Score: 706.5
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 793
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251798
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.02
    Marker Score: 34622
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71816
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48041
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 505
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.98
    Marker Score: 558
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 459
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 0.94
    Marker Score: 524
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.94
    Marker Score: 433
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5329
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 370
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 323
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5282
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.87
    Marker Score: 200
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.84
    Marker Score: 1171
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.83
    Marker Score: 1566
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.82
    Marker Score: 2140
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.81
    Marker Score: 1644
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8
    Marker Score: 49340
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.8
    Marker Score: 5175
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1259
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 706
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.76
    Marker Score: 1576
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 393
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 459
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.71
    Marker Score: 4261
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.65
    Marker Score: 632
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.65
    Marker Score: 234
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.65
    Marker Score: 431
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.63
    Marker Score: 546
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.61
    Marker Score: 402
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.61
    Marker Score: 12934
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.6
    Marker Score: 170
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.58
    Marker Score: 460
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 146
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.55
    Marker Score: 230
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 172
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.54
    Marker Score: 5149
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.52
    Marker Score: 163
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.51
    Marker Score: 957
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 0.5
    Marker Score: 647
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.48
    Marker Score: 590
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.47
    Marker Score: 281
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.46
    Marker Score: 430
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.46
    Marker Score: 1073
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.43
    Marker Score: 656
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.42
    Marker Score: 407
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 0.41
    Marker Score: 948
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.41
    Marker Score: 6435
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.41
    Marker Score: 214.5
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.41
    Marker Score: 148
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.4
    Marker Score: 168
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.4
    Marker Score: 1232
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0.39
    Marker Score: 2970
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.39
    Marker Score: 453
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.38
    Marker Score: 121
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.38
    Marker Score: 213
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 368
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.36
    Marker Score: 93
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.33
    Marker Score: 660
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.32
    Marker Score: 233
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.32
    Marker Score: 1714
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.32
    Marker Score: 511
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.31
    Marker Score: 91
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.31
    Marker Score: 278
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.31
    Marker Score: 151
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.3
    Marker Score: 439
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.29
    Marker Score: 2509
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.29
    Marker Score: 154
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 0.28
    Marker Score: 80
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.28
    Marker Score: 135
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.28
    Marker Score: 4471
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.27
    Marker Score: 103
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.27
    Marker Score: 67
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.27
    Marker Score: 67
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.27
    Marker Score: 151
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.26
    Marker Score: 106
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.26
    Marker Score: 90
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.26
    Marker Score: 132
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.25
    Marker Score: 252
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.25
    Marker Score: 296
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.25
    Marker Score: 178.5

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** * The protein is a secreted protein with a molecular weight of approximately 120 kDa. * It is expressed in high levels in the lungs, intestine, and kidney. * It is a key regulator of collagen catabolism. * It is involved in the regulation of cell adhesion and migration. * It is a potential therapeutic target for a variety of diseases, including cancer and fibrosis. **Pathways and functions:** * The protein is involved in the regulation of angiogenesis by binding to collagen type I and stimulating the production of vascular endothelial growth factor (VEGF). * It is also involved in cell adhesion and migration by binding to integrins and other extracellular matrix proteins. * It is involved in the regulation of inflammation by binding to inflammatory cytokines and promoting the production of anti-inflammatory cytokines. * It is involved in the catabolism of collagen by proteolytic cleavage. **Clinical significance:** The FAP gene has been linked to a number of human diseases, including cancer and fibrosis. It is a potential therapeutic target for a variety of diseases, including cancer and fibrosis. For example, the inhibition of FAP has been shown to inhibit tumor growth and migration in cancer cells. **Additional information:** * The gene is located on chromosome 17q25. * It is expressed in all cell types tested in humans. * It is a highly conserved gene, with a similar gene found in mice.

Genular Protein ID: 3955094465

Symbol: SEPR_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7911242

Title: Molecular cloning of fibroblast activation protein alpha, a member of the serine protease family selectively expressed in stromal fibroblasts of epithelial cancers.

PubMed ID: 7911242

DOI: 10.1073/pnas.91.12.5657

PubMed ID: 9247085

Title: Molecular cloning of seprase: a serine integral membrane protease from human melanoma.

PubMed ID: 9247085

DOI: 10.1016/s0925-4439(97)00032-x

PubMed ID: 9065413

Title: Identification of the 170-kDa melanoma membrane-bound gelatinase (seprase) as a serine integral membrane protease.

PubMed ID: 9065413

DOI: 10.1074/jbc.272.12.7595

PubMed ID: 10644713

Title: Identification of an alternatively spliced seprase mRNA that encodes a novel intracellular isoform.

PubMed ID: 10644713

DOI: 10.1074/jbc.275.4.2554

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14751930

Title: A novel plasma proteinase potentiates alpha2-antiplasmin inhibition of fibrin digestion.

PubMed ID: 14751930

DOI: 10.1182/blood-2003-12-4240

PubMed ID: 7519584

Title: Fibroblast activation protein: purification, epitope mapping and induction by growth factors.

PubMed ID: 7519584

DOI: 10.1002/ijc.2910580314

PubMed ID: 2172980

Title: A 170-kDa membrane-bound protease is associated with the expression of invasiveness by human malignant melanoma cells.

PubMed ID: 2172980

DOI: 10.1073/pnas.87.21.8296

PubMed ID: 7923219

Title: A potential marker protease of invasiveness, seprase, is localized on invadopodia of human malignant melanoma cells.

PubMed ID: 7923219

PubMed ID: 10347120

Title: Fibroblast activation protein: a cell surface dipeptidyl peptidase and gelatinase expressed by stellate cells at the tissue remodelling interface in human cirrhosis.

PubMed ID: 10347120

DOI: 10.1002/hep.510290631

PubMed ID: 10593948

Title: Fibroblast activation protein, a dual specificity serine protease expressed in reactive human tumor stromal fibroblasts.

PubMed ID: 10593948

DOI: 10.1074/jbc.274.51.36505

PubMed ID: 10455171

Title: A novel protease-docking function of integrin at invadopodia.

PubMed ID: 10455171

DOI: 10.1074/jbc.274.35.24947

PubMed ID: 12376466

Title: Molecular proximity of seprase and the urokinase-type plasminogen activator receptor on malignant melanoma cell membranes: dependence on beta1 integrins and the cytoskeleton.

PubMed ID: 12376466

DOI: 10.1093/carcin/23.10.1593

PubMed ID: 16175601

Title: Fibroblast activation protein increases apoptosis, cell adhesion, and migration by the LX-2 human stellate cell line.

PubMed ID: 16175601

DOI: 10.1002/hep.20853

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 17105646

Title: Fibroblast activation protein is expressed by rheumatoid myofibroblast-like synoviocytes.

PubMed ID: 17105646

DOI: 10.1186/ar2080

PubMed ID: 16223769

Title: Antiplasmin-cleaving enzyme is a soluble form of fibroblast activation protein.

PubMed ID: 16223769

DOI: 10.1182/blood-2005-08-3452

PubMed ID: 16651416

Title: The protease complex consisting of dipeptidyl peptidase IV and seprase plays a role in the migration and invasion of human endothelial cells in collagenous matrices.

PubMed ID: 16651416

DOI: 10.1158/0008-5472.can-05-1245

PubMed ID: 16480718

Title: Peptide substrate profiling defines fibroblast activation protein as an endopeptidase of strict Gly(2)-Pro(1)-cleaving specificity.

PubMed ID: 16480718

DOI: 10.1016/j.febslet.2006.01.087

PubMed ID: 16410248

Title: Selective inhibition of fibroblast activation protein protease based on dipeptide substrate specificity.

PubMed ID: 16410248

DOI: 10.1074/jbc.m511112200

PubMed ID: 17381073

Title: Ala657 and conserved active site residues promote fibroblast activation protein endopeptidase activity via distinct mechanisms of transition state stabilization.

PubMed ID: 17381073

DOI: 10.1021/bi062227y

PubMed ID: 18095711

Title: Fibroblast activation protein peptide substrates identified from human collagen I derived gelatin cleavage sites.

PubMed ID: 18095711

DOI: 10.1021/bi701921b

PubMed ID: 18262497

Title: Seprase: an overview of an important matrix serine protease.

PubMed ID: 18262497

DOI: 10.1016/j.bbapap.2008.01.006

PubMed ID: 20707604

Title: Expression and role of the cell surface protease seprase/fibroblast activation protein-alpha (FAP-alpha) in astroglial tumors.

PubMed ID: 20707604

DOI: 10.1515/bc.2010.119

PubMed ID: 21314817

Title: Neuropeptide Y, B-type natriuretic peptide, substance P and peptide YY are novel substrates of fibroblast activation protein-alpha.

PubMed ID: 21314817

DOI: 10.1111/j.1742-4658.2011.08051.x

PubMed ID: 21288888

Title: Cleavage-site specificity of prolyl endopeptidase FAP investigated with a full-length protein substrate.

PubMed ID: 21288888

DOI: 10.1093/jb/mvr017

PubMed ID: 24371721

Title: Quantitation of fibroblast activation protein (FAP)-specific protease activity in mouse, baboon and human fluids and organs.

PubMed ID: 24371721

DOI: 10.1016/j.fob.2013.12.001

PubMed ID: 24717288

Title: A rare variant in human fibroblast activation protein associated with ER stress, loss of enzymatic function and loss of cell surface localisation.

PubMed ID: 24717288

DOI: 10.1016/j.bbapap.2014.03.015

PubMed ID: 15809306

Title: Structural and kinetic analysis of the substrate specificity of human fibroblast activation protein alpha.

PubMed ID: 15809306

DOI: 10.1074/jbc.c500092200

Sequence Information:

  • Length: 760
  • Mass: 87713
  • Checksum: 7FF817B5A4F75142
  • Sequence:
  • MKTWVKIVFG VATSAVLALL VMCIVLRPSR VHNSEENTMR ALTLKDILNG TFSYKTFFPN 
    WISGQEYLHQ SADNNIVLYN IETGQSYTIL SNRTMKSVNA SNYGLSPDRQ FVYLESDYSK 
    LWRYSYTATY YIYDLSNGEF VRGNELPRPI QYLCWSPVGS KLAYVYQNNI YLKQRPGDPP 
    FQITFNGREN KIFNGIPDWV YEEEMLATKY ALWWSPNGKF LAYAEFNDTD IPVIAYSYYG 
    DEQYPRTINI PYPKAGAKNP VVRIFIIDTT YPAYVGPQEV PVPAMIASSD YYFSWLTWVT 
    DERVCLQWLK RVQNVSVLSI CDFREDWQTW DCPKTQEHIE ESRTGWAGGF FVSTPVFSYD 
    AISYYKIFSD KDGYKHIHYI KDTVENAIQI TSGKWEAINI FRVTQDSLFY SSNEFEEYPG 
    RRNIYRISIG SYPPSKKCVT CHLRKERCQY YTASFSDYAK YYALVCYGPG IPISTLHDGR 
    TDQEIKILEE NKELENALKN IQLPKEEIKK LEVDEITLWY KMILPPQFDR SKKYPLLIQV 
    YGGPCSQSVR SVFAVNWISY LASKEGMVIA LVDGRGTAFQ GDKLLYAVYR KLGVYEVEDQ 
    ITAVRKFIEM GFIDEKRIAI WGWSYGGYVS SLALASGTGL FKCGIAVAPV SSWEYYASVY 
    TERFMGLPTK DDNLEHYKNS TVMARAEYFR NVDYLLIHGT ADDNVHFQNS AQIAKALVNA 
    QVDFQAMWYS DQNHGLSGLS TNHLYTHMTH FLKQCFSLSD

Genular Protein ID: 3398505832

Symbol: B4DLR2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

  • Length: 735
  • Mass: 84862
  • Checksum: A6ABE4083721544D
  • Sequence:
  • MKTWVKIVFG VATSAVLALL VMCIVLRPSR VHNSEENTMR ALTLKDILNG TFSYKTFFPN 
    WISGQEYLHQ SADNNIVLYN IETGQSYTIL SNRTMLWRYS YTATYYIYDL SNGEFVRGNE 
    LPRPIQYLCW SPVGSKLAYV YQNNIYLKQR PGDPPFQITF NGRENKIFNG IPDWVYEEEM 
    LATKYALWWS PNGKFLAYAE FNDTDIPVIA YSYYGDEQYP RTINIPYPKA GAKNPVVRIF 
    IIDTTYPAYV GPQEVPVPAM IASSDYYFSW LTWVTDERVC LQWLKRVQNV SVLSICDFRE 
    DWQTWDCPKT QEHIEESRTG WAGGFFVSTP VFSYDAISYY KIFSDKDGYK HIHYIKDTVE 
    NAIQITSGKW EAINIFRVTQ DSLFYSSNEF EEYPGRRNIY RISIGSYPPS KKCVTCHLRK 
    ERCQYYTASF SDYAKYYALV CYGPGIPIST LHDGRTDQEI KILEENKELE NALKNIQLPK 
    EEIKKLEVDE ITLWYKMILP PQFDRSKKYP LLIQVYGGPC SQSVRSVFAV NWISYLASKE 
    GMVIALVDGR GTAFQGDKLL YAVYRKLGVY EVEDQITAVR KFIEMGFIDE KRIAIWGWSY 
    GGYVSSLALA SGTGLFKCGI AVAPVSSWEY YASVYTERFM GLPTKDDNLE HYKNSTVMAR 
    AEYFRNVDYL LIHGTADDNV HFQNSAQIAK ALVNAQVDFQ AMWYSDQNHG LSGLSTNHLY 
    THMTHFLKQC FSLSD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.