Details for: FAP
Associated with
Cells (max top 100)
(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: 2.33
Marker Score: 3197 - Cell Name: type A enteroendocrine cell (CL0002067)
Fold Change: 1.71
Marker Score: 688 - Cell Name: decidual cell (CL2000002)
Fold Change: 1.61
Marker Score: 6943 - Cell Name: mural cell (CL0008034)
Fold Change: 1.47
Marker Score: 168726 - Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 1.43
Marker Score: 905.5 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 1.41
Marker Score: 15827 - Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.37
Marker Score: 866 - Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 1.27
Marker Score: 2451 - Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
Fold Change: 1.25
Marker Score: 281 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 1.17
Marker Score: 484 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.15
Marker Score: 4808 - Cell Name: mesangial cell (CL0000650)
Fold Change: 1.1
Marker Score: 1332 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.04
Marker Score: 706.5 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: 1.04
Marker Score: 793 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.04
Marker Score: 251798 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.02
Marker Score: 34622 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71816 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48041 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30407 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.98
Marker Score: 505 - Cell Name: fibroblast of breast (CL4006000)
Fold Change: 0.98
Marker Score: 558 - Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.97
Marker Score: 459 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2412 - Cell Name: alveolar type 2 fibroblast cell (CL4028006)
Fold Change: 0.94
Marker Score: 524 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.94
Marker Score: 433 - Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.93
Marker Score: 5329 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.92
Marker Score: 370 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2740 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9
Marker Score: 323 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5282 - Cell Name: keratocyte (CL0002363)
Fold Change: 0.87
Marker Score: 200 - Cell Name: Mueller cell (CL0000636)
Fold Change: 0.84
Marker Score: 1171 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.83
Marker Score: 1566 - Cell Name: fibroblast of lung (CL0002553)
Fold Change: 0.82
Marker Score: 2140 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.81
Marker Score: 1644 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.8
Marker Score: 49340 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.8
Marker Score: 5175 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1259 - Cell Name: brush cell (CL0002204)
Fold Change: 0.77
Marker Score: 706 - Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 0.76
Marker Score: 1576 - Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 393 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.72
Marker Score: 459 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.71
Marker Score: 4261 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 177 - Cell Name: fibroblast (CL0000057)
Fold Change: 0.65
Marker Score: 632 - Cell Name: gut endothelial cell (CL0000131)
Fold Change: 0.65
Marker Score: 234 - Cell Name: precursor B cell (CL0000817)
Fold Change: 0.65
Marker Score: 431 - Cell Name: astrocyte (CL0000127)
Fold Change: 0.63
Marker Score: 546 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 0.61
Marker Score: 402 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 0.61
Marker Score: 12934 - Cell Name: preosteoblast (CL0007010)
Fold Change: 0.6
Marker Score: 170 - Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.58
Marker Score: 460 - Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.55
Marker Score: 146 - Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.55
Marker Score: 230 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.54
Marker Score: 172 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 0.54
Marker Score: 5149 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 0.52
Marker Score: 163 - Cell Name: supporting cell (CL0000630)
Fold Change: 0.51
Marker Score: 957 - Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 0.5
Marker Score: 647 - Cell Name: myofibroblast cell (CL0000186)
Fold Change: 0.48
Marker Score: 590 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.47
Marker Score: 281 - Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 0.46
Marker Score: 430 - Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.46
Marker Score: 1073 - Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 0.43
Marker Score: 656 - Cell Name: pro-B cell (CL0000826)
Fold Change: 0.42
Marker Score: 407 - Cell Name: macroglial cell (CL0000126)
Fold Change: 0.41
Marker Score: 948 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.41
Marker Score: 6435 - Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 0.41
Marker Score: 214.5 - Cell Name: reticular cell (CL0000432)
Fold Change: 0.41
Marker Score: 148 - Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 0.4
Marker Score: 168 - Cell Name: Unknown (CL0000003)
Fold Change: 0.4
Marker Score: 1232 - Cell Name: granule cell (CL0000120)
Fold Change: 0.39
Marker Score: 2970 - Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 0.39
Marker Score: 453 - Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.38
Marker Score: 121 - Cell Name: cerebellar granule cell precursor (CL0002362)
Fold Change: 0.38
Marker Score: 213 - Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.37
Marker Score: 368 - Cell Name: skin fibroblast (CL0002620)
Fold Change: 0.36
Marker Score: 93 - Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 0.33
Marker Score: 660 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.32
Marker Score: 233 - Cell Name: stellate neuron (CL0000122)
Fold Change: 0.32
Marker Score: 1714 - Cell Name: myeloid cell (CL0000763)
Fold Change: 0.32
Marker Score: 511 - Cell Name: tracheobronchial smooth muscle cell (CL0019019)
Fold Change: 0.31
Marker Score: 91 - Cell Name: endothelial cell (CL0000115)
Fold Change: 0.31
Marker Score: 278 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.31
Marker Score: 151 - Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 0.3
Marker Score: 439 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 0.29
Marker Score: 2509 - Cell Name: osteoblast (CL0000062)
Fold Change: 0.29
Marker Score: 154 - Cell Name: meningeal macrophage (CL0000879)
Fold Change: 0.28
Marker Score: 80 - Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.28
Marker Score: 135 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.28
Marker Score: 4471 - Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 0.27
Marker Score: 103 - Cell Name: fibroblast of connective tissue of prostate (CL1000299)
Fold Change: 0.27
Marker Score: 67 - Cell Name: prostate stromal cell (CL0002622)
Fold Change: 0.27
Marker Score: 67 - Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.27
Marker Score: 151 - Cell Name: melanocyte (CL0000148)
Fold Change: 0.26
Marker Score: 106 - Cell Name: ependymal cell (CL0000065)
Fold Change: 0.26
Marker Score: 90 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: 0.26
Marker Score: 132 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.25
Marker Score: 252 - Cell Name: stromal cell (CL0000499)
Fold Change: 0.25
Marker Score: 296 - Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 0.25
Marker Score: 178.5
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Other Information
Genular Protein ID: 3955094465
Symbol: SEPR_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7911242
Title: Molecular cloning of fibroblast activation protein alpha, a member of the serine protease family selectively expressed in stromal fibroblasts of epithelial cancers.
PubMed ID: 7911242
PubMed ID: 9247085
Title: Molecular cloning of seprase: a serine integral membrane protease from human melanoma.
PubMed ID: 9247085
PubMed ID: 9065413
Title: Identification of the 170-kDa melanoma membrane-bound gelatinase (seprase) as a serine integral membrane protease.
PubMed ID: 9065413
PubMed ID: 10644713
Title: Identification of an alternatively spliced seprase mRNA that encodes a novel intracellular isoform.
PubMed ID: 10644713
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 14751930
Title: A novel plasma proteinase potentiates alpha2-antiplasmin inhibition of fibrin digestion.
PubMed ID: 14751930
PubMed ID: 7519584
Title: Fibroblast activation protein: purification, epitope mapping and induction by growth factors.
PubMed ID: 7519584
PubMed ID: 2172980
Title: A 170-kDa membrane-bound protease is associated with the expression of invasiveness by human malignant melanoma cells.
PubMed ID: 2172980
PubMed ID: 7923219
Title: A potential marker protease of invasiveness, seprase, is localized on invadopodia of human malignant melanoma cells.
PubMed ID: 7923219
PubMed ID: 10347120
Title: Fibroblast activation protein: a cell surface dipeptidyl peptidase and gelatinase expressed by stellate cells at the tissue remodelling interface in human cirrhosis.
PubMed ID: 10347120
PubMed ID: 10593948
Title: Fibroblast activation protein, a dual specificity serine protease expressed in reactive human tumor stromal fibroblasts.
PubMed ID: 10593948
PubMed ID: 10455171
Title: A novel protease-docking function of integrin at invadopodia.
PubMed ID: 10455171
PubMed ID: 12376466
Title: Molecular proximity of seprase and the urokinase-type plasminogen activator receptor on malignant melanoma cell membranes: dependence on beta1 integrins and the cytoskeleton.
PubMed ID: 12376466
PubMed ID: 16175601
Title: Fibroblast activation protein increases apoptosis, cell adhesion, and migration by the LX-2 human stellate cell line.
PubMed ID: 16175601
DOI: 10.1002/hep.20853
PubMed ID: 16335952
Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.
PubMed ID: 16335952
DOI: 10.1021/pr0502065
PubMed ID: 17105646
Title: Fibroblast activation protein is expressed by rheumatoid myofibroblast-like synoviocytes.
PubMed ID: 17105646
DOI: 10.1186/ar2080
PubMed ID: 16223769
Title: Antiplasmin-cleaving enzyme is a soluble form of fibroblast activation protein.
PubMed ID: 16223769
PubMed ID: 16651416
Title: The protease complex consisting of dipeptidyl peptidase IV and seprase plays a role in the migration and invasion of human endothelial cells in collagenous matrices.
PubMed ID: 16651416
PubMed ID: 16480718
Title: Peptide substrate profiling defines fibroblast activation protein as an endopeptidase of strict Gly(2)-Pro(1)-cleaving specificity.
PubMed ID: 16480718
PubMed ID: 16410248
Title: Selective inhibition of fibroblast activation protein protease based on dipeptide substrate specificity.
PubMed ID: 16410248
PubMed ID: 17381073
Title: Ala657 and conserved active site residues promote fibroblast activation protein endopeptidase activity via distinct mechanisms of transition state stabilization.
PubMed ID: 17381073
DOI: 10.1021/bi062227y
PubMed ID: 18095711
Title: Fibroblast activation protein peptide substrates identified from human collagen I derived gelatin cleavage sites.
PubMed ID: 18095711
DOI: 10.1021/bi701921b
PubMed ID: 18262497
Title: Seprase: an overview of an important matrix serine protease.
PubMed ID: 18262497
PubMed ID: 20707604
Title: Expression and role of the cell surface protease seprase/fibroblast activation protein-alpha (FAP-alpha) in astroglial tumors.
PubMed ID: 20707604
DOI: 10.1515/bc.2010.119
PubMed ID: 21314817
Title: Neuropeptide Y, B-type natriuretic peptide, substance P and peptide YY are novel substrates of fibroblast activation protein-alpha.
PubMed ID: 21314817
PubMed ID: 21288888
Title: Cleavage-site specificity of prolyl endopeptidase FAP investigated with a full-length protein substrate.
PubMed ID: 21288888
DOI: 10.1093/jb/mvr017
PubMed ID: 24371721
Title: Quantitation of fibroblast activation protein (FAP)-specific protease activity in mouse, baboon and human fluids and organs.
PubMed ID: 24371721
PubMed ID: 24717288
Title: A rare variant in human fibroblast activation protein associated with ER stress, loss of enzymatic function and loss of cell surface localisation.
PubMed ID: 24717288
PubMed ID: 15809306
Title: Structural and kinetic analysis of the substrate specificity of human fibroblast activation protein alpha.
PubMed ID: 15809306
Sequence Information:
- Length: 760
- Mass: 87713
- Checksum: 7FF817B5A4F75142
- Sequence:
MKTWVKIVFG VATSAVLALL VMCIVLRPSR VHNSEENTMR ALTLKDILNG TFSYKTFFPN WISGQEYLHQ SADNNIVLYN IETGQSYTIL SNRTMKSVNA SNYGLSPDRQ FVYLESDYSK LWRYSYTATY YIYDLSNGEF VRGNELPRPI QYLCWSPVGS KLAYVYQNNI YLKQRPGDPP FQITFNGREN KIFNGIPDWV YEEEMLATKY ALWWSPNGKF LAYAEFNDTD IPVIAYSYYG DEQYPRTINI PYPKAGAKNP VVRIFIIDTT YPAYVGPQEV PVPAMIASSD YYFSWLTWVT DERVCLQWLK RVQNVSVLSI CDFREDWQTW DCPKTQEHIE ESRTGWAGGF FVSTPVFSYD AISYYKIFSD KDGYKHIHYI KDTVENAIQI TSGKWEAINI FRVTQDSLFY SSNEFEEYPG RRNIYRISIG SYPPSKKCVT CHLRKERCQY YTASFSDYAK YYALVCYGPG IPISTLHDGR TDQEIKILEE NKELENALKN IQLPKEEIKK LEVDEITLWY KMILPPQFDR SKKYPLLIQV YGGPCSQSVR SVFAVNWISY LASKEGMVIA LVDGRGTAFQ GDKLLYAVYR KLGVYEVEDQ ITAVRKFIEM GFIDEKRIAI WGWSYGGYVS SLALASGTGL FKCGIAVAPV SSWEYYASVY TERFMGLPTK DDNLEHYKNS TVMARAEYFR NVDYLLIHGT ADDNVHFQNS AQIAKALVNA QVDFQAMWYS DQNHGLSGLS TNHLYTHMTH FLKQCFSLSD
Genular Protein ID: 3398505832
Symbol: B4DLR2_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
Sequence Information:
- Length: 735
- Mass: 84862
- Checksum: A6ABE4083721544D
- Sequence:
MKTWVKIVFG VATSAVLALL VMCIVLRPSR VHNSEENTMR ALTLKDILNG TFSYKTFFPN WISGQEYLHQ SADNNIVLYN IETGQSYTIL SNRTMLWRYS YTATYYIYDL SNGEFVRGNE LPRPIQYLCW SPVGSKLAYV YQNNIYLKQR PGDPPFQITF NGRENKIFNG IPDWVYEEEM LATKYALWWS PNGKFLAYAE FNDTDIPVIA YSYYGDEQYP RTINIPYPKA GAKNPVVRIF IIDTTYPAYV GPQEVPVPAM IASSDYYFSW LTWVTDERVC LQWLKRVQNV SVLSICDFRE DWQTWDCPKT QEHIEESRTG WAGGFFVSTP VFSYDAISYY KIFSDKDGYK HIHYIKDTVE NAIQITSGKW EAINIFRVTQ DSLFYSSNEF EEYPGRRNIY RISIGSYPPS KKCVTCHLRK ERCQYYTASF SDYAKYYALV CYGPGIPIST LHDGRTDQEI KILEENKELE NALKNIQLPK EEIKKLEVDE ITLWYKMILP PQFDRSKKYP LLIQVYGGPC SQSVRSVFAV NWISYLASKE GMVIALVDGR GTAFQGDKLL YAVYRKLGVY EVEDQITAVR KFIEMGFIDE KRIAIWGWSY GGYVSSLALA SGTGLFKCGI AVAPVSSWEY YASVYTERFM GLPTKDDNLE HYKNSTVMAR AEYFRNVDYL LIHGTADDNV HFQNSAQIAK ALVNAQVDFQ AMWYSDQNHG LSGLSTNHLY THMTHFLKQC FSLSD
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.