Details for: FAP

Gene ID: 2191

Symbol: FAP

Ensembl ID: ENSG00000078098

Description: fibroblast activation protein alpha

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 4.5089
    Cell Significance Index: 69.7600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 2.9058
    Cell Significance Index: 93.0700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.7039
    Cell Significance Index: 58.5800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.6248
    Cell Significance Index: 34.0100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.3246
    Cell Significance Index: 60.0400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.0022
    Cell Significance Index: 28.7300
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.9874
    Cell Significance Index: 6.6900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.8751
    Cell Significance Index: 17.0800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.8433
    Cell Significance Index: 10.8000
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.6209
    Cell Significance Index: 9.8500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6168
    Cell Significance Index: 61.0200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.5827
    Cell Significance Index: 29.4500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5724
    Cell Significance Index: 516.8200
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.3769
    Cell Significance Index: 2.3700
  • Cell Name: chondroblast (CL0000058)
    Fold Change: 0.3765
    Cell Significance Index: 2.2100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3587
    Cell Significance Index: 71.9600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3388
    Cell Significance Index: 55.1000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3368
    Cell Significance Index: 36.6400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3324
    Cell Significance Index: 7.0800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2261
    Cell Significance Index: 43.0300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2212
    Cell Significance Index: 13.2800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1696
    Cell Significance Index: 11.7300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0909
    Cell Significance Index: 5.1000
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.0533
    Cell Significance Index: 0.4100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.0487
    Cell Significance Index: 1.0400
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.0364
    Cell Significance Index: 0.2300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0196
    Cell Significance Index: 0.6900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0028
    Cell Significance Index: 0.3800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0046
    Cell Significance Index: -8.7500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0066
    Cell Significance Index: -4.8700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0113
    Cell Significance Index: -20.9000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0128
    Cell Significance Index: -4.5900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0131
    Cell Significance Index: -9.0500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0137
    Cell Significance Index: -21.0400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0142
    Cell Significance Index: -0.4100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0157
    Cell Significance Index: -21.4000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0183
    Cell Significance Index: -1.1200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0192
    Cell Significance Index: -12.1700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0195
    Cell Significance Index: -14.7300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0206
    Cell Significance Index: -9.1100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0212
    Cell Significance Index: -0.5300
  • Cell Name: endothelial stalk cell (CL0002671)
    Fold Change: -0.0214
    Cell Significance Index: -0.2400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0252
    Cell Significance Index: -14.2200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0257
    Cell Significance Index: -16.0600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0299
    Cell Significance Index: -16.3300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0353
    Cell Significance Index: -16.0100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0461
    Cell Significance Index: -13.2500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0507
    Cell Significance Index: -6.5000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0517
    Cell Significance Index: -9.3300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0563
    Cell Significance Index: -11.1800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0795
    Cell Significance Index: -16.7500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0844
    Cell Significance Index: -10.3800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0911
    Cell Significance Index: -15.5500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0944
    Cell Significance Index: -9.8300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1011
    Cell Significance Index: -14.6900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1064
    Cell Significance Index: -13.7400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1143
    Cell Significance Index: -13.3200
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.1192
    Cell Significance Index: -0.5700
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.1212
    Cell Significance Index: -1.3600
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.1224
    Cell Significance Index: -0.7500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1307
    Cell Significance Index: -1.9700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1331
    Cell Significance Index: -8.3900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1354
    Cell Significance Index: -13.8300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1434
    Cell Significance Index: -16.4300
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.1546
    Cell Significance Index: -1.4900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1735
    Cell Significance Index: -3.6000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1847
    Cell Significance Index: -14.1700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1887
    Cell Significance Index: -8.8700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1930
    Cell Significance Index: -12.9800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1943
    Cell Significance Index: -14.4800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2117
    Cell Significance Index: -5.9200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2189
    Cell Significance Index: -11.4000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2209
    Cell Significance Index: -5.9200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.2221
    Cell Significance Index: -3.1900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2234
    Cell Significance Index: -14.4100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2243
    Cell Significance Index: -5.9900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2293
    Cell Significance Index: -9.9700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2297
    Cell Significance Index: -2.6100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2387
    Cell Significance Index: -11.1300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2665
    Cell Significance Index: -16.3800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2770
    Cell Significance Index: -7.1200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2787
    Cell Significance Index: -6.7500
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.2968
    Cell Significance Index: -4.1500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3205
    Cell Significance Index: -16.8300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3236
    Cell Significance Index: -14.3200
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.3528
    Cell Significance Index: -4.9600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3576
    Cell Significance Index: -5.9900
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.3578
    Cell Significance Index: -5.0900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3658
    Cell Significance Index: -11.6500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3662
    Cell Significance Index: -19.0300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3713
    Cell Significance Index: -14.0600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3752
    Cell Significance Index: -15.3800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4011
    Cell Significance Index: -14.0500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4087
    Cell Significance Index: -14.2000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4178
    Cell Significance Index: -13.6800
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.4438
    Cell Significance Index: -5.9200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.4471
    Cell Significance Index: -11.1500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4505
    Cell Significance Index: -12.0500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4548
    Cell Significance Index: -13.4000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4584
    Cell Significance Index: -13.0800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Fibroblast Activation Protein Alpha: A Multifaceted Enzyme in Immune and Non-Immune Tissues** As an expert immunologist, it is essential to recognize the complex role of fibroblast activation protein alpha (FAP) in various biological processes. FAP, also known as matrilysin, is a serine protease that belongs to the prolyl peptidase family. Its expression is widespread, with significant levels detected in various cell types, including bronchus fibroblast of lung, type A enteroendocrine cell, decidual cell, mural cell, pancreatic stellate cell, stromal cell of ovary, granulocyte monocyte progenitor cell, kidney interstitial fibroblast, stromal cell of lamina propria of small intestine, and transit amplifying cell of small intestine. **Key Characteristics of FAP** 1. **Cellular localization**: FAP is primarily localized to the cell surface, where it can interact with various ligands and substrates, influencing cell adhesion, migration, and proliferation. 2. **Enzymatic activity**: FAP possesses a wide range of enzymatic activities, including dipeptidyl-peptidase, endopeptidase, and serine-type endopeptidase activities, which enable it to degrade various protein substrates. 3. **Proteolytic processing**: FAP is involved in the proteolytic processing of several proteins, including growth factors, cytokines, and chemokines, which can modulate immune responses and cell signaling pathways. 4. **Angiogenesis**: FAP has been implicated in angiogenesis, a process crucial for tumor growth and metastasis. Its enzymatic activity can promote the degradation of the extracellular matrix, facilitating endothelial cell migration and vessel formation. **Pathways and Functions of FAP** 1. **Apoptosis regulation**: FAP can regulate apoptosis by processing and activating pro-apoptotic proteins, such as caspase-3 and Bax. 2. **Cell adhesion and migration**: FAP interacts with integrins and other cell surface receptors, influencing cell adhesion, migration, and invasion. 3. **Extracellular matrix remodeling**: FAP can degrade the extracellular matrix, facilitating tissue remodeling and angiogenesis. 4. **Immune response modulation**: FAP can modulate immune responses by processing and activating immune-related proteins, such as cytokines and chemokines. 5. **Tumor growth and metastasis**: FAP has been implicated in tumor growth and metastasis, particularly in cancers with high angiogenic potential. **Clinical Significance of FAP** 1. **Cancer diagnosis and prognosis**: Elevated FAP expression has been associated with various types of cancer, including lung, breast, and colon cancer. Its expression can serve as a diagnostic biomarker and prognostic indicator. 2. **Angiogenesis and metastasis**: FAP's role in angiogenesis and tumor growth highlights its potential as a therapeutic target for cancer treatment. 3. **Fibrosis and tissue remodeling**: FAP's involvement in extracellular matrix remodeling and tissue fibrosis suggests its potential as a therapeutic target for fibrotic diseases, such as pulmonary fibrosis and liver cirrhosis. 4. **Autoimmune diseases**: FAP's role in immune response modulation and tissue remodeling may also be relevant to autoimmune diseases, such as rheumatoid arthritis and lupus. In conclusion, FAP is a multifaceted enzyme with a wide range of biological activities, from cell adhesion and migration to apoptosis regulation and tumor growth. Its expression and activity are critical in various physiological and pathological processes, making it an attractive target for therapeutic interventions in cancer, fibrosis, and autoimmune diseases.

Genular Protein ID: 3955094465

Symbol: SEPR_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q12884 O00199 Q53TP5 Q86Z29 Q99998 Q9UID4

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 2 EMBL 6 ESTHER 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 35 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7911242

Title: Molecular cloning of fibroblast activation protein alpha, a member of the serine protease family selectively expressed in stromal fibroblasts of epithelial cancers.

PubMed ID: 7911242

DOI: 10.1073/pnas.91.12.5657

PubMed ID: 9247085

Title: Molecular cloning of seprase: a serine integral membrane protease from human melanoma.

PubMed ID: 9247085

DOI: 10.1016/s0925-4439(97)00032-x

PubMed ID: 9065413

Title: Identification of the 170-kDa melanoma membrane-bound gelatinase (seprase) as a serine integral membrane protease.

PubMed ID: 9065413

DOI: 10.1074/jbc.272.12.7595

PubMed ID: 10644713

Title: Identification of an alternatively spliced seprase mRNA that encodes a novel intracellular isoform.

PubMed ID: 10644713

DOI: 10.1074/jbc.275.4.2554

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14751930

Title: A novel plasma proteinase potentiates alpha2-antiplasmin inhibition of fibrin digestion.

PubMed ID: 14751930

DOI: 10.1182/blood-2003-12-4240

PubMed ID: 7519584

Title: Fibroblast activation protein: purification, epitope mapping and induction by growth factors.

PubMed ID: 7519584

DOI: 10.1002/ijc.2910580314

PubMed ID: 2172980

Title: A 170-kDa membrane-bound protease is associated with the expression of invasiveness by human malignant melanoma cells.

PubMed ID: 2172980

DOI: 10.1073/pnas.87.21.8296

PubMed ID: 7923219

Title: A potential marker protease of invasiveness, seprase, is localized on invadopodia of human malignant melanoma cells.

PubMed ID: 7923219

PubMed ID: 10347120

Title: Fibroblast activation protein: a cell surface dipeptidyl peptidase and gelatinase expressed by stellate cells at the tissue remodelling interface in human cirrhosis.

PubMed ID: 10347120

DOI: 10.1002/hep.510290631

PubMed ID: 10593948

Title: Fibroblast activation protein, a dual specificity serine protease expressed in reactive human tumor stromal fibroblasts.

PubMed ID: 10593948

DOI: 10.1074/jbc.274.51.36505

PubMed ID: 10455171

Title: A novel protease-docking function of integrin at invadopodia.

PubMed ID: 10455171

DOI: 10.1074/jbc.274.35.24947

PubMed ID: 12376466

Title: Molecular proximity of seprase and the urokinase-type plasminogen activator receptor on malignant melanoma cell membranes: dependence on beta1 integrins and the cytoskeleton.

PubMed ID: 12376466

DOI: 10.1093/carcin/23.10.1593

PubMed ID: 16175601

Title: Fibroblast activation protein increases apoptosis, cell adhesion, and migration by the LX-2 human stellate cell line.

PubMed ID: 16175601

DOI: 10.1002/hep.20853

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 17105646

Title: Fibroblast activation protein is expressed by rheumatoid myofibroblast-like synoviocytes.

PubMed ID: 17105646

DOI: 10.1186/ar2080

PubMed ID: 16223769

Title: Antiplasmin-cleaving enzyme is a soluble form of fibroblast activation protein.

PubMed ID: 16223769

DOI: 10.1182/blood-2005-08-3452

PubMed ID: 16651416

Title: The protease complex consisting of dipeptidyl peptidase IV and seprase plays a role in the migration and invasion of human endothelial cells in collagenous matrices.

PubMed ID: 16651416

DOI: 10.1158/0008-5472.can-05-1245

PubMed ID: 16480718

Title: Peptide substrate profiling defines fibroblast activation protein as an endopeptidase of strict Gly(2)-Pro(1)-cleaving specificity.

PubMed ID: 16480718

DOI: 10.1016/j.febslet.2006.01.087

PubMed ID: 16410248

Title: Selective inhibition of fibroblast activation protein protease based on dipeptide substrate specificity.

PubMed ID: 16410248

DOI: 10.1074/jbc.m511112200

PubMed ID: 17381073

Title: Ala657 and conserved active site residues promote fibroblast activation protein endopeptidase activity via distinct mechanisms of transition state stabilization.

PubMed ID: 17381073

DOI: 10.1021/bi062227y

PubMed ID: 18095711

Title: Fibroblast activation protein peptide substrates identified from human collagen I derived gelatin cleavage sites.

PubMed ID: 18095711

DOI: 10.1021/bi701921b

PubMed ID: 18262497

Title: Seprase: an overview of an important matrix serine protease.

PubMed ID: 18262497

DOI: 10.1016/j.bbapap.2008.01.006

PubMed ID: 20707604

Title: Expression and role of the cell surface protease seprase/fibroblast activation protein-alpha (FAP-alpha) in astroglial tumors.

PubMed ID: 20707604

DOI: 10.1515/bc.2010.119

PubMed ID: 21314817

Title: Neuropeptide Y, B-type natriuretic peptide, substance P and peptide YY are novel substrates of fibroblast activation protein-alpha.

PubMed ID: 21314817

DOI: 10.1111/j.1742-4658.2011.08051.x

PubMed ID: 21288888

Title: Cleavage-site specificity of prolyl endopeptidase FAP investigated with a full-length protein substrate.

PubMed ID: 21288888

DOI: 10.1093/jb/mvr017

PubMed ID: 24371721

Title: Quantitation of fibroblast activation protein (FAP)-specific protease activity in mouse, baboon and human fluids and organs.

PubMed ID: 24371721

DOI: 10.1016/j.fob.2013.12.001

PubMed ID: 24717288

Title: A rare variant in human fibroblast activation protein associated with ER stress, loss of enzymatic function and loss of cell surface localisation.

PubMed ID: 24717288

DOI: 10.1016/j.bbapap.2014.03.015

PubMed ID: 15809306

Title: Structural and kinetic analysis of the substrate specificity of human fibroblast activation protein alpha.

PubMed ID: 15809306

DOI: 10.1074/jbc.c500092200

Sequence Information:

  • Length: 760
  • Mass: 87713
  • Checksum: 7FF817B5A4F75142
  • Sequence:
    • MKTWVKIVFG VATSAVLALL VMCIVLRPSR VHNSEENTMR ALTLKDILNG TFSYKTFFPN 
WISGQEYLHQ SADNNIVLYN IETGQSYTIL SNRTMKSVNA SNYGLSPDRQ FVYLESDYSK 
LWRYSYTATY YIYDLSNGEF VRGNELPRPI QYLCWSPVGS KLAYVYQNNI YLKQRPGDPP 
FQITFNGREN KIFNGIPDWV YEEEMLATKY ALWWSPNGKF LAYAEFNDTD IPVIAYSYYG 
DEQYPRTINI PYPKAGAKNP VVRIFIIDTT YPAYVGPQEV PVPAMIASSD YYFSWLTWVT 
DERVCLQWLK RVQNVSVLSI CDFREDWQTW DCPKTQEHIE ESRTGWAGGF FVSTPVFSYD 
AISYYKIFSD KDGYKHIHYI KDTVENAIQI TSGKWEAINI FRVTQDSLFY SSNEFEEYPG 
RRNIYRISIG SYPPSKKCVT CHLRKERCQY YTASFSDYAK YYALVCYGPG IPISTLHDGR 
TDQEIKILEE NKELENALKN IQLPKEEIKK LEVDEITLWY KMILPPQFDR SKKYPLLIQV 
YGGPCSQSVR SVFAVNWISY LASKEGMVIA LVDGRGTAFQ GDKLLYAVYR KLGVYEVEDQ 
ITAVRKFIEM GFIDEKRIAI WGWSYGGYVS SLALASGTGL FKCGIAVAPV SSWEYYASVY 
TERFMGLPTK DDNLEHYKNS TVMARAEYFR NVDYLLIHGT ADDNVHFQNS AQIAKALVNA 
QVDFQAMWYS DQNHGLSGLS TNHLYTHMTH FLKQCFSLSD

Genular Protein ID: 3398505832

Symbol: B4DLR2_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DLR2

Database IDs:

ARBA 5 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 ESTHER 1 Ensembl 2 GO 4 Gene3D 2 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 5 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 PeptideAtlas 1 Pfam 4 Proteomes 2 ProteomicsDB 2 RefSeq 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

Sequence Information:

  • Length: 735
  • Mass: 84862
  • Checksum: A6ABE4083721544D
  • Sequence:
    • MKTWVKIVFG VATSAVLALL VMCIVLRPSR VHNSEENTMR ALTLKDILNG TFSYKTFFPN 
WISGQEYLHQ SADNNIVLYN IETGQSYTIL SNRTMLWRYS YTATYYIYDL SNGEFVRGNE 
LPRPIQYLCW SPVGSKLAYV YQNNIYLKQR PGDPPFQITF NGRENKIFNG IPDWVYEEEM 
LATKYALWWS PNGKFLAYAE FNDTDIPVIA YSYYGDEQYP RTINIPYPKA GAKNPVVRIF 
IIDTTYPAYV GPQEVPVPAM IASSDYYFSW LTWVTDERVC LQWLKRVQNV SVLSICDFRE 
DWQTWDCPKT QEHIEESRTG WAGGFFVSTP VFSYDAISYY KIFSDKDGYK HIHYIKDTVE 
NAIQITSGKW EAINIFRVTQ DSLFYSSNEF EEYPGRRNIY RISIGSYPPS KKCVTCHLRK 
ERCQYYTASF SDYAKYYALV CYGPGIPIST LHDGRTDQEI KILEENKELE NALKNIQLPK 
EEIKKLEVDE ITLWYKMILP PQFDRSKKYP LLIQVYGGPC SQSVRSVFAV NWISYLASKE 
GMVIALVDGR GTAFQGDKLL YAVYRKLGVY EVEDQITAVR KFIEMGFIDE KRIAIWGWSY 
GGYVSSLALA SGTGLFKCGI AVAPVSSWEY YASVYTERFM GLPTKDDNLE HYKNSTVMAR 
AEYFRNVDYL LIHGTADDNV HFQNSAQIAK ALVNAQVDFQ AMWYSDQNHG LSGLSTNHLY 
THMTHFLKQC FSLSD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.