Details for: GAS2

Gene ID: 2620

Symbol: GAS2

Ensembl ID: ENSG00000148935

Description: growth arrest specific 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 80.6250
    Cell Significance Index: -20.4500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 3.2137
    Cell Significance Index: 637.7700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 2.4243
    Cell Significance Index: 186.0400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 2.2189
    Cell Significance Index: 54.1400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.8909
    Cell Significance Index: 379.3100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.1613
    Cell Significance Index: 33.1400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.0018
    Cell Significance Index: 37.9400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.9148
    Cell Significance Index: 15.4100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.9118
    Cell Significance Index: 40.3300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.8772
    Cell Significance Index: 166.9300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7285
    Cell Significance Index: 20.9900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5167
    Cell Significance Index: 23.4200
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 0.4426
    Cell Significance Index: 4.6100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4399
    Cell Significance Index: 43.5200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4316
    Cell Significance Index: 9.3500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.3862
    Cell Significance Index: 9.6300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.3798
    Cell Significance Index: 25.5400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3508
    Cell Significance Index: 316.7200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3365
    Cell Significance Index: 20.2000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3306
    Cell Significance Index: 118.5800
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.3224
    Cell Significance Index: 4.0200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.3034
    Cell Significance Index: 6.3500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2831
    Cell Significance Index: 30.8000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2712
    Cell Significance Index: 6.7800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2588
    Cell Significance Index: 14.5200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2415
    Cell Significance Index: 39.2800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2229
    Cell Significance Index: 11.5800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.2073
    Cell Significance Index: 3.0600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2049
    Cell Significance Index: 7.2000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.1676
    Cell Significance Index: 24.3600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.1523
    Cell Significance Index: 3.1600
  • Cell Name: chondroblast (CL0000058)
    Fold Change: 0.1516
    Cell Significance Index: 0.8900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1479
    Cell Significance Index: 26.6600
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.1393
    Cell Significance Index: 1.1500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0898
    Cell Significance Index: 5.5200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0814
    Cell Significance Index: 56.3300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0780
    Cell Significance Index: 1.8700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0630
    Cell Significance Index: 4.3600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0517
    Cell Significance Index: 22.8600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0432
    Cell Significance Index: 79.6000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0341
    Cell Significance Index: 52.5100
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: 0.0317
    Cell Significance Index: 0.4000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0266
    Cell Significance Index: 50.0100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.0240
    Cell Significance Index: 0.5100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0185
    Cell Significance Index: 11.7600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0149
    Cell Significance Index: 2.5400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0029
    Cell Significance Index: 3.9600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0006
    Cell Significance Index: -0.0800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0012
    Cell Significance Index: -0.0200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0014
    Cell Significance Index: -0.0400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0039
    Cell Significance Index: -0.1000
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.0116
    Cell Significance Index: -0.1500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0184
    Cell Significance Index: -13.6600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0224
    Cell Significance Index: -10.1600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0251
    Cell Significance Index: -18.3900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0263
    Cell Significance Index: -14.8600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0290
    Cell Significance Index: -21.9400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0344
    Cell Significance Index: -21.4800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0366
    Cell Significance Index: -19.9800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0588
    Cell Significance Index: -16.9300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0691
    Cell Significance Index: -3.0100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0705
    Cell Significance Index: -1.0400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0730
    Cell Significance Index: -1.0500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0848
    Cell Significance Index: -2.3700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0927
    Cell Significance Index: -19.5200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1001
    Cell Significance Index: -1.9800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1045
    Cell Significance Index: -1.7900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1062
    Cell Significance Index: -6.5100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1063
    Cell Significance Index: -12.3900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1067
    Cell Significance Index: -13.6800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1091
    Cell Significance Index: -12.5000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1104
    Cell Significance Index: -6.9600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1163
    Cell Significance Index: -11.8800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1247
    Cell Significance Index: -2.7300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1341
    Cell Significance Index: -18.4200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1503
    Cell Significance Index: -3.2000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1543
    Cell Significance Index: -19.9400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1751
    Cell Significance Index: -20.6500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1827
    Cell Significance Index: -19.0300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1918
    Cell Significance Index: -3.8500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1985
    Cell Significance Index: -5.3200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2166
    Cell Significance Index: -6.9000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2435
    Cell Significance Index: -19.2900
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.2488
    Cell Significance Index: -3.1900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2540
    Cell Significance Index: -18.9300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2618
    Cell Significance Index: -8.5700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2640
    Cell Significance Index: -6.5900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2931
    Cell Significance Index: -20.7300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2973
    Cell Significance Index: -13.8600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3164
    Cell Significance Index: -16.6100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3194
    Cell Significance Index: -11.1900
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.3215
    Cell Significance Index: -4.8100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3221
    Cell Significance Index: -20.7800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3316
    Cell Significance Index: -17.2800
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.3445
    Cell Significance Index: -7.1900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3446
    Cell Significance Index: -16.2000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3698
    Cell Significance Index: -7.9900
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.3962
    Cell Significance Index: -6.8500
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.4372
    Cell Significance Index: -5.1000
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.4399
    Cell Significance Index: -4.1700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** GAS2 is a small, non-essential protein with a molecular weight of approximately 14 kDa. Its expression is tightly regulated, with a broad tissue distribution that includes hepatoblasts, cardiac myocytes, epithelial cells, and neurons. Notably, GAS2 exhibits a unique ability to interact with cytoskeletal proteins, actin filaments, and microtubules, suggesting its involvement in maintaining cellular shape and structure. Furthermore, GAS2 displays a remarkable capacity for stress fiber formation, a feature essential for regulating cell growth and division. **Pathways and Functions:** GAS2's involvement in various cellular pathways is a testament to its multifunctional nature. Some of its notable roles include: 1. **Apoptosis and Programmed Cell Death**: GAS2 has been implicated in the regulation of apoptosis, a process crucial for maintaining tissue homeostasis and eliminating damaged or unwanted cells. 2. **Cell Cycle Regulation**: GAS2 interacts with cytoskeletal proteins to regulate cell cycle progression, ensuring proper cell division and preventing uncontrolled growth. 3. **Cytoskeletal Organization**: GAS2's ability to interact with actin filaments and microtubules is essential for maintaining cellular shape and structure. 4. **Stress Fiber Formation**: GAS2's capacity to form stress fibers is critical for regulating cell growth and division in response to environmental stressors. 5. **Notch Signaling Pathway**: GAS2 has been shown to interact with the Notch signaling pathway, a crucial regulator of cell fate decisions and tissue development. **Clinical Significance:** Given its widespread expression and involvement in various cellular processes, GAS2 has significant implications for human health and disease. Dysregulation of GAS2 has been linked to various conditions, including: 1. **Cancer**: Alterations in GAS2 expression have been observed in various cancers, suggesting its potential role as a tumor suppressor or oncogene. 2. **Neurodegenerative Diseases**: GAS2's involvement in neuronal function and survival makes it a potential therapeutic target for neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Cardiovascular Disease**: GAS2's role in regulating cardiac myocyte function and structure makes it a potential target for the prevention and treatment of cardiovascular disease. In conclusion, GAS2 is a complex protein with far-reaching implications for cellular homeostasis. Its multifunctional nature and widespread expression make it an attractive target for therapeutic intervention in various diseases. Further research is needed to fully elucidate the mechanisms underlying GAS2's functions and to explore its potential as a therapeutic agent.

Genular Protein ID: 4022267215

Symbol: GAS2_HUMAN

Name: Growth arrest-specific protein 2

UniProtKB Accession Codes:

O43903 B2R9C8 D3DQZ0 Q6ICV8 Q7Z3X8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 4 ExpressionAtlas 1 GO 16 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 7 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9521882

Title: cDNA characterization and chromosome mapping of the human GAS2 gene.

PubMed ID: 9521882

DOI: 10.1006/geno.1997.5172

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 24706950

Title: GAS2-like proteins mediate communication between microtubules and actin through interactions with end-binding proteins.

PubMed ID: 24706950

DOI: 10.1242/jcs.140558

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 313
  • Mass: 34945
  • Checksum: A5FBA611A0C8B36F
  • Sequence:
    • MCTALSPKVR SGPGLSDMHQ YSQWLASRHE ANLLPMKEDL ALWLTNLLGK EITAETFMEK 
LDNGALLCQL AETMQEKFKE SMDANKPTKN LPLKKIPCKT SAPSGSFFAR DNTANFLSWC 
RDLGVDETCL FESEGLVLHK QPREVCLCLL ELGRIAARYG VEPPGLIKLE KEIEQEETLS 
APSPSPSPSS KSSGKKSTGN LLDDAVKRIS EDPPCKCPNK FCVERLSQGR YRVGEKILFI 
RMLHNKHVMV RVGGGWETFA GYLLKHDPCR MLQISRVDGK TSPIQSKSPT LKDMNPDNYL 
VVSASYKAKK EIK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.