Details for: CL0002131

Cell ID: CL0002131

Cell Name: regular ventricular cardiac myocyte

Marker Score Threshold: 22,347
(Derived using integrated single-cell and genomic data)

Description: Regular cardiac myocyte of a cardiac ventricle.

Synonyms: ventricular cardiac muscle cell, regular cardiac muscle cell of ventricle, regular ventricular cardiac muscle fiber, ventricular myocyte

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: CACNA1C (ENSG00000151067)
    Fold Change: 5.44
    Ensembl ID: ENSG00000151067
  • Gene Symbol: MYBPC3 (ENSG00000134571)
    Fold Change: 5.44
    Ensembl ID: ENSG00000134571
  • Gene Symbol: FHL2 (ENSG00000115641)
    Fold Change: 5.42
    Ensembl ID: ENSG00000115641
  • Gene Symbol: LAMA2 (ENSG00000196569)
    Fold Change: 5.42
    Ensembl ID: ENSG00000196569
  • Gene Symbol: ABLIM1 (ENSG00000099204)
    Fold Change: 5.4
    Ensembl ID: ENSG00000099204
  • Gene Symbol: FGF12 (ENSG00000114279)
    Fold Change: 5.38
    Ensembl ID: ENSG00000114279
  • Gene Symbol: DMD (ENSG00000198947)
    Fold Change: 5.35
    Ensembl ID: ENSG00000198947
  • Gene Symbol: CACNB2 (ENSG00000165995)
    Fold Change: 5.28
    Ensembl ID: ENSG00000165995
  • Gene Symbol: PPP1R12B (ENSG00000077157)
    Fold Change: 5.17
    Ensembl ID: ENSG00000077157
  • Gene Symbol: CD36 (ENSG00000135218)
    Fold Change: 5.11
    Ensembl ID: ENSG00000135218
  • Gene Symbol: CDH13 (ENSG00000140945)
    Fold Change: 5.08
    Ensembl ID: ENSG00000140945
  • Gene Symbol: LPP (ENSG00000145012)
    Fold Change: 5.05
    Ensembl ID: ENSG00000145012
  • Gene Symbol: DLG2 (ENSG00000150672)
    Fold Change: 4.99
    Ensembl ID: ENSG00000150672
  • Gene Symbol: PRKN (ENSG00000185345)
    Fold Change: 4.96
    Ensembl ID: ENSG00000185345
  • Gene Symbol: CDH2 (ENSG00000170558)
    Fold Change: 4.96
    Ensembl ID: ENSG00000170558
  • Gene Symbol: ACTN2 (ENSG00000077522)
    Fold Change: 4.95
    Ensembl ID: ENSG00000077522
  • Gene Symbol: MYH7 (ENSG00000092054)
    Fold Change: 4.94
    Ensembl ID: ENSG00000092054
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 4.87
    Ensembl ID: ENSG00000151914
  • Gene Symbol: CAMK2D (ENSG00000145349)
    Fold Change: 4.84
    Ensembl ID: ENSG00000145349
  • Gene Symbol: ANK2 (ENSG00000145362)
    Fold Change: 4.79
    Ensembl ID: ENSG00000145362
  • Gene Symbol: DTNA (ENSG00000134769)
    Fold Change: 4.74
    Ensembl ID: ENSG00000134769
  • Gene Symbol: CKMT2 (ENSG00000131730)
    Fold Change: 4.71
    Ensembl ID: ENSG00000131730
  • Gene Symbol: MYL2 (ENSG00000111245)
    Fold Change: 4.65
    Ensembl ID: ENSG00000111245
  • Gene Symbol: ESRRG (ENSG00000196482)
    Fold Change: 4.64
    Ensembl ID: ENSG00000196482
  • Gene Symbol: DES (ENSG00000175084)
    Fold Change: 4.63
    Ensembl ID: ENSG00000175084
  • Gene Symbol: FHIT (ENSG00000189283)
    Fold Change: 4.6
    Ensembl ID: ENSG00000189283
  • Gene Symbol: MAP4 (ENSG00000047849)
    Fold Change: 4.6
    Ensembl ID: ENSG00000047849
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 4.57
    Ensembl ID: ENSG00000174437
  • Gene Symbol: PAM (ENSG00000145730)
    Fold Change: 4.53
    Ensembl ID: ENSG00000145730
  • Gene Symbol: CBLB (ENSG00000114423)
    Fold Change: 4.53
    Ensembl ID: ENSG00000114423
  • Gene Symbol: ACTC1 (ENSG00000159251)
    Fold Change: 4.52
    Ensembl ID: ENSG00000159251
  • Gene Symbol: ERBB4 (ENSG00000178568)
    Fold Change: 4.44
    Ensembl ID: ENSG00000178568
  • Gene Symbol: NCAM1 (ENSG00000149294)
    Fold Change: 4.42
    Ensembl ID: ENSG00000149294
  • Gene Symbol: CALD1 (ENSG00000122786)
    Fold Change: 4.39
    Ensembl ID: ENSG00000122786
  • Gene Symbol: MEIS2 (ENSG00000134138)
    Fold Change: 4.35
    Ensembl ID: ENSG00000134138
  • Gene Symbol: MITF (ENSG00000187098)
    Fold Change: 4.33
    Ensembl ID: ENSG00000187098
  • Gene Symbol: EFNA5 (ENSG00000184349)
    Fold Change: 4.33
    Ensembl ID: ENSG00000184349
  • Gene Symbol: NFIA (ENSG00000162599)
    Fold Change: 4.31
    Ensembl ID: ENSG00000162599
  • Gene Symbol: SLC25A4 (ENSG00000151729)
    Fold Change: 4.3
    Ensembl ID: ENSG00000151729
  • Gene Symbol: MBNL1 (ENSG00000152601)
    Fold Change: 4.29
    Ensembl ID: ENSG00000152601
  • Gene Symbol: MEF2A (ENSG00000068305)
    Fold Change: 4.28
    Ensembl ID: ENSG00000068305
  • Gene Symbol: ACACB (ENSG00000076555)
    Fold Change: 4.22
    Ensembl ID: ENSG00000076555
  • Gene Symbol: ANK3 (ENSG00000151150)
    Fold Change: 4.2
    Ensembl ID: ENSG00000151150
  • Gene Symbol: CACNA2D1 (ENSG00000153956)
    Fold Change: 4.17
    Ensembl ID: ENSG00000153956
  • Gene Symbol: CHRM2 (ENSG00000181072)
    Fold Change: 4.16
    Ensembl ID: ENSG00000181072
  • Gene Symbol: LMO7 (ENSG00000136153)
    Fold Change: 4.16
    Ensembl ID: ENSG00000136153
  • Gene Symbol: CUX1 (ENSG00000257923)
    Fold Change: 4.06
    Ensembl ID: ENSG00000257923
  • Gene Symbol: KTN1 (ENSG00000126777)
    Fold Change: 4.02
    Ensembl ID: ENSG00000126777
  • Gene Symbol: NFIB (ENSG00000147862)
    Fold Change: 3.98
    Ensembl ID: ENSG00000147862
  • Gene Symbol: ROR1 (ENSG00000185483)
    Fold Change: 3.96
    Ensembl ID: ENSG00000185483
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 3.89
    Ensembl ID: ENSG00000142599
  • Gene Symbol: PBX1 (ENSG00000185630)
    Fold Change: 3.85
    Ensembl ID: ENSG00000185630
  • Gene Symbol: MPP3 (ENSG00000161647)
    Fold Change: 3.8
    Ensembl ID: ENSG00000161647
  • Gene Symbol: DDX5 (ENSG00000108654)
    Fold Change: 3.79
    Ensembl ID: ENSG00000108654
  • Gene Symbol: LTBP1 (ENSG00000049323)
    Fold Change: 3.76
    Ensembl ID: ENSG00000049323
  • Gene Symbol: GBE1 (ENSG00000114480)
    Fold Change: 3.75
    Ensembl ID: ENSG00000114480
  • Gene Symbol: GOLGA4 (ENSG00000144674)
    Fold Change: 3.74
    Ensembl ID: ENSG00000144674
  • Gene Symbol: NRAP (ENSG00000197893)
    Fold Change: 3.73
    Ensembl ID: ENSG00000197893
  • Gene Symbol: MARK3 (ENSG00000075413)
    Fold Change: 3.63
    Ensembl ID: ENSG00000075413
  • Gene Symbol: ACYP2 (ENSG00000170634)
    Fold Change: 3.62
    Ensembl ID: ENSG00000170634
  • Gene Symbol: GATA4 (ENSG00000136574)
    Fold Change: 3.61
    Ensembl ID: ENSG00000136574
  • Gene Symbol: CRYAB (ENSG00000109846)
    Fold Change: 3.61
    Ensembl ID: ENSG00000109846
  • Gene Symbol: MYL3 (ENSG00000160808)
    Fold Change: 3.56
    Ensembl ID: ENSG00000160808
  • Gene Symbol: HADHB (ENSG00000138029)
    Fold Change: 3.53
    Ensembl ID: ENSG00000138029
  • Gene Symbol: INSR (ENSG00000171105)
    Fold Change: 3.47
    Ensembl ID: ENSG00000171105
  • Gene Symbol: DGKG (ENSG00000058866)
    Fold Change: 3.45
    Ensembl ID: ENSG00000058866
  • Gene Symbol: GAB1 (ENSG00000109458)
    Fold Change: 3.45
    Ensembl ID: ENSG00000109458
  • Gene Symbol: MB (ENSG00000198125)
    Fold Change: 3.39
    Ensembl ID: ENSG00000198125
  • Gene Symbol: AQP7 (ENSG00000165269)
    Fold Change: 3.37
    Ensembl ID: ENSG00000165269
  • Gene Symbol: IGF1R (ENSG00000140443)
    Fold Change: 3.36
    Ensembl ID: ENSG00000140443
  • Gene Symbol: MGAT5 (ENSG00000152127)
    Fold Change: 3.35
    Ensembl ID: ENSG00000152127
  • Gene Symbol: LRP4 (ENSG00000134569)
    Fold Change: 3.32
    Ensembl ID: ENSG00000134569
  • Gene Symbol: MKLN1 (ENSG00000128585)
    Fold Change: 3.27
    Ensembl ID: ENSG00000128585
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 3.27
    Ensembl ID: ENSG00000104763
  • Gene Symbol: CASQ2 (ENSG00000118729)
    Fold Change: 3.26
    Ensembl ID: ENSG00000118729
  • Gene Symbol: CSNK1A1 (ENSG00000113712)
    Fold Change: 3.26
    Ensembl ID: ENSG00000113712
  • Gene Symbol: EYA4 (ENSG00000112319)
    Fold Change: 3.26
    Ensembl ID: ENSG00000112319
  • Gene Symbol: NF1 (ENSG00000196712)
    Fold Change: 3.18
    Ensembl ID: ENSG00000196712
  • Gene Symbol: ADK (ENSG00000156110)
    Fold Change: 3.17
    Ensembl ID: ENSG00000156110
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.11
    Ensembl ID: ENSG00000075624
  • Gene Symbol: ADCY5 (ENSG00000173175)
    Fold Change: 3.1
    Ensembl ID: ENSG00000173175
  • Gene Symbol: GCNT2 (ENSG00000111846)
    Fold Change: 3.08
    Ensembl ID: ENSG00000111846
  • Gene Symbol: GAS2 (ENSG00000148935)
    Fold Change: 3.08
    Ensembl ID: ENSG00000148935
  • Gene Symbol: CTNNA1 (ENSG00000044115)
    Fold Change: 3.07
    Ensembl ID: ENSG00000044115
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 3.06
    Ensembl ID: ENSG00000153113
  • Gene Symbol: OGDH (ENSG00000105953)
    Fold Change: 3.06
    Ensembl ID: ENSG00000105953
  • Gene Symbol: MEF2C (ENSG00000081189)
    Fold Change: 3.05
    Ensembl ID: ENSG00000081189
  • Gene Symbol: CKM (ENSG00000104879)
    Fold Change: 3.04
    Ensembl ID: ENSG00000104879
  • Gene Symbol: ACO2 (ENSG00000100412)
    Fold Change: 3.04
    Ensembl ID: ENSG00000100412
  • Gene Symbol: DOCK3 (ENSG00000088538)
    Fold Change: 3.03
    Ensembl ID: ENSG00000088538
  • Gene Symbol: FOXN3 (ENSG00000053254)
    Fold Change: 3.02
    Ensembl ID: ENSG00000053254
  • Gene Symbol: BRAF (ENSG00000157764)
    Fold Change: 3.01
    Ensembl ID: ENSG00000157764
  • Gene Symbol: BMPR1A (ENSG00000107779)
    Fold Change: 3
    Ensembl ID: ENSG00000107779
  • Gene Symbol: LPL (ENSG00000175445)
    Fold Change: 2.99
    Ensembl ID: ENSG00000175445
  • Gene Symbol: MDH1 (ENSG00000014641)
    Fold Change: 2.98
    Ensembl ID: ENSG00000014641
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 2.98
    Ensembl ID: ENSG00000184009
  • Gene Symbol: LDLRAD4 (ENSG00000168675)
    Fold Change: 2.97
    Ensembl ID: ENSG00000168675
  • Gene Symbol: ATP1B1 (ENSG00000143153)
    Fold Change: 2.94
    Ensembl ID: ENSG00000143153
  • Gene Symbol: FKBP5 (ENSG00000096060)
    Fold Change: 2.93
    Ensembl ID: ENSG00000096060
  • Gene Symbol: ETFDH (ENSG00000171503)
    Fold Change: 2.92
    Ensembl ID: ENSG00000171503

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in regular ventricular cardiac myocyte cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in regular ventricular cardiac myocyte cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.
**Key Characteristics** * **Cell Type**: Regular ventricular cardiac myocyte * **Location**: Ventricles of the heart * **Function**: Regulates heart rate and contraction * **Genes**: + CACNA1C: Involved in calcium-mediated signaling + MYBPC3: Involved in muscle contraction and sarcomere organization + FHL2: Involved in muscle contraction and lipid metabolism + LAMA2: Involved in cell adhesion and basement membrane organization + ABLIM1: Involved in actin cytoskeleton organization and nervous system development + FGF12: Involved in cardiac conduction and muscle contraction + DMD: Involved in muscle contraction and cellular homeostasis * **Pathways/Ontology**: Adrenaline, noradrenaline inhibits insulin secretion, Alpha-actinin binding, Axon guidance, Calcium-mediated signaling using extracellular calcium source, Calcium ion import across plasma membrane, Calcium ion transmembrane transport, Calcium ion transmembrane transport via high voltage-gated calcium channel, Calcium ion transport into cytosol, Calmodulin binding, Camera-type eye development, Cardiac conduction, Cardiac muscle cell action potential involved in contraction, Cell communication by electrical coupling involved in cardiac conduction, Cytoplasm, Dendrite, Developmental biology, Embryonic forelimb morphogenesis, Heart development, High voltage-gated calcium channel activity, Immune system development, Integration of energy metabolism, L-type voltage-gated calcium channel complex, Membrane, Membrane depolarization during atrial cardiac muscle cell action potential, Membrane depolarization during av node cell action potential, Membrane depolarization during cardiac muscle cell action potential, Metabolism, Metal ion binding, Muscle contraction, Ncam1 interactions, Ncam signaling for neurite out-growth, Nervous system development, Perikaryon, Phase 0 - rapid depolarisation, Phase 2 - plateau phase, Plasma membrane, Positive regulation of adenylate cyclase activity, Positive regulation of cytosolic calcium ion concentration, Postsynaptic density, Postsynaptic density membrane, Protein binding, Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion, Regulation of heart rate by cardiac conduction, Regulation of insulin secretion, Regulation of ventricular cardiac muscle cell action potential, Voltage-gated calcium channel activity, Voltage-gated calcium channel activity involved in av node cell action potential, Voltage-gated calcium channel activity involved in cardiac muscle cell action potential, Voltage-gated calcium channel complex, Z disc **Clinical Significance** Regular ventricular cardiac myocytes play a crucial role in regulating heart function and are involved in various cardiovascular diseases. Alterations in the expression or function of these cells can lead to conditions such as: * **Hypertrophic cardiomyopathy**: A condition characterized by thickening of the heart muscle, which can lead to impaired heart function and increased risk of heart failure. * **Arrhythmias**: Abnormal heart rhythms that can be caused by disruptions in the normal functioning of cardiac myocytes. * **Cardiac conduction disorders**: Conditions that affect the electrical conduction system of the heart, leading to irregular heartbeats and other cardiac complications. Understanding the function and regulation of regular ventricular cardiac myocytes is essential for the development of effective treatments and therapies for cardiovascular diseases.