Details for: GRIK1

Gene ID: 2897

Symbol: GRIK1

Ensembl ID: ENSG00000171189

Description: glutamate ionotropic receptor kainate type subunit 1

Associated with

  • Activation of ca-permeable kainate receptor
    (R-HSA-451308)
  • Activation of kainate receptors upon glutamate binding
    (R-HSA-451326)
  • Activation of na-permeable kainate receptors
    (R-HSA-451307)
  • Ionotropic activity of kainate receptors
    (R-HSA-451306)
  • Neuronal system
    (R-HSA-112316)
  • Neurotransmitter receptors and postsynaptic signal transmission
    (R-HSA-112314)
  • Transmission across chemical synapses
    (R-HSA-112315)
  • Calcium-mediated signaling
    (GO:0019722)
  • Central nervous system development
    (GO:0007417)
  • Chemical synaptic transmission
    (GO:0007268)
  • Glutamate-gated calcium ion channel activity
    (GO:0022849)
  • Glutamate-gated receptor activity
    (GO:0004970)
  • Glutamate receptor signaling pathway
    (GO:0007215)
  • Intracellular membrane-bounded organelle
    (GO:0043231)
  • Ionotropic glutamate receptor signaling pathway
    (GO:0035235)
  • Kainate selective glutamate receptor activity
    (GO:0015277)
  • Kainate selective glutamate receptor complex
    (GO:0032983)
  • Modulation of chemical synaptic transmission
    (GO:0050804)
  • Monoatomic ion transmembrane transport
    (GO:0034220)
  • Nervous system development
    (GO:0007399)
  • Plasma membrane
    (GO:0005886)
  • Postsynaptic density membrane
    (GO:0098839)
  • Presynaptic membrane
    (GO:0042734)
  • Regulation of postsynaptic membrane potential
    (GO:0060078)
  • Regulation of synaptic transmission, glutamatergic
    (GO:0051966)
  • Synaptic transmission, glutamatergic
    (GO:0035249)
  • Transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
    (GO:1904315)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 85.8323
    Cell Significance Index: -34.8700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 16.7566
    Cell Significance Index: 366.9100
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 5.3098
    Cell Significance Index: 68.8600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 5.1638
    Cell Significance Index: 1852.1800
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 3.8882
    Cell Significance Index: 29.9700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 3.3915
    Cell Significance Index: 208.4600
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 3.0605
    Cell Significance Index: 26.9600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 2.7507
    Cell Significance Index: 68.7600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 2.0848
    Cell Significance Index: 50.0000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.8653
    Cell Significance Index: 53.2300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.4984
    Cell Significance Index: 1036.3200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.0721
    Cell Significance Index: 48.6000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7117
    Cell Significance Index: 135.4400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6287
    Cell Significance Index: 126.1100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5058
    Cell Significance Index: 456.7100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4318
    Cell Significance Index: 42.7200
  • Cell Name: chandelier cell (CL4023083)
    Fold Change: 0.3071
    Cell Significance Index: 2.4800
  • Cell Name: diffuse bipolar 1 cell (CL4033027)
    Fold Change: 0.1774
    Cell Significance Index: 2.1700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1670
    Cell Significance Index: 33.1500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1541
    Cell Significance Index: 2.6400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1445
    Cell Significance Index: 8.1100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1415
    Cell Significance Index: 3.7200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.1406
    Cell Significance Index: 2.7800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0975
    Cell Significance Index: 15.8500
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0.0883
    Cell Significance Index: 1.0700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0839
    Cell Significance Index: 38.0800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0808
    Cell Significance Index: 2.8400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0405
    Cell Significance Index: 55.0700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0364
    Cell Significance Index: 68.4500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0185
    Cell Significance Index: 28.4500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0043
    Cell Significance Index: 7.9500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.0024
    Cell Significance Index: 0.0500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0017
    Cell Significance Index: 0.0300
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.0119
    Cell Significance Index: -0.1200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0205
    Cell Significance Index: -13.0000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0288
    Cell Significance Index: -0.8300
  • Cell Name: flat midget bipolar cell (CL4033033)
    Fold Change: -0.0314
    Cell Significance Index: -0.3900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0498
    Cell Significance Index: -36.9000
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.0527
    Cell Significance Index: -0.8500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0593
    Cell Significance Index: -33.4400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0595
    Cell Significance Index: -8.6500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0636
    Cell Significance Index: -39.7100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0752
    Cell Significance Index: -41.0800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0810
    Cell Significance Index: -8.8100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0834
    Cell Significance Index: -6.4000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0873
    Cell Significance Index: -2.4400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0971
    Cell Significance Index: -1.9500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.1037
    Cell Significance Index: -18.7000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1051
    Cell Significance Index: -2.6200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1080
    Cell Significance Index: -31.0800
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1220
    Cell Significance Index: -1.5400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1426
    Cell Significance Index: -3.0800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1564
    Cell Significance Index: -9.5900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1668
    Cell Significance Index: -28.4900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1840
    Cell Significance Index: -38.7500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.2155
    Cell Significance Index: -26.5000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2244
    Cell Significance Index: -28.7700
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.2258
    Cell Significance Index: -2.7000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.2443
    Cell Significance Index: -3.0300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.2489
    Cell Significance Index: -34.1800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.2707
    Cell Significance Index: -18.7200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2866
    Cell Significance Index: -37.0300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.3177
    Cell Significance Index: -32.4500
  • Cell Name: diffuse bipolar 2 cell (CL4033028)
    Fold Change: -0.3224
    Cell Significance Index: -3.9600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3368
    Cell Significance Index: -35.0700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3438
    Cell Significance Index: -39.3900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3469
    Cell Significance Index: -40.9100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3702
    Cell Significance Index: -24.8900
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.4207
    Cell Significance Index: -8.2800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4313
    Cell Significance Index: -32.1500
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.4878
    Cell Significance Index: -10.1800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.4996
    Cell Significance Index: -12.1900
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.5380
    Cell Significance Index: -5.1000
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.5537
    Cell Significance Index: -6.4600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5583
    Cell Significance Index: -14.3500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.5595
    Cell Significance Index: -33.5900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.5664
    Cell Significance Index: -12.2700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.5907
    Cell Significance Index: -37.2300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.6271
    Cell Significance Index: -27.2700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.6645
    Cell Significance Index: -34.5200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.6671
    Cell Significance Index: -34.7500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.6731
    Cell Significance Index: -16.7900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6745
    Cell Significance Index: -23.6300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.6760
    Cell Significance Index: -35.5000
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.6964
    Cell Significance Index: -8.7900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.7574
    Cell Significance Index: -35.6000
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.7643
    Cell Significance Index: -9.5300
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.7701
    Cell Significance Index: -10.0500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.7868
    Cell Significance Index: -15.6900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.7932
    Cell Significance Index: -25.9700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.7974
    Cell Significance Index: -35.2700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.8378
    Cell Significance Index: -39.0600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.8562
    Cell Significance Index: -27.2700
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.9101
    Cell Significance Index: -11.6700
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.9444
    Cell Significance Index: -29.8700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.9588
    Cell Significance Index: -20.5000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.9604
    Cell Significance Index: -30.7600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.9626
    Cell Significance Index: -36.4500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.9910
    Cell Significance Index: -26.4600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.9914
    Cell Significance Index: -34.4500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Ionotropic receptor**: GRIK1 is a ligand-gated ion channel that allows the flow of monovalent cations (such as potassium and sodium) into the cell upon glutamate binding. 2. **Kainate receptor subunit**: GRIK1 is a member of the kainate receptor family, which is distinct from the AMPA and NMDA receptor subfamilies. 3. **Ca-permeable and Na-permeable receptors**: GRIK1 receptors can be either calcium-permeable or sodium-permeable, depending on the specific isoform and co-assembly with other subunits. 4. **Regulation of synaptic transmission**: GRIK1 receptors modulate synaptic transmission by regulating the postsynaptic membrane potential and influencing the excitability of neurons. **Pathways and Functions:** 1. **Glutamate receptor signaling pathway**: GRIK1 is part of the glutamate receptor signaling pathway, which is involved in the regulation of synaptic transmission and neuronal excitability. 2. **Activation of kainate receptors**: GRIK1 receptors are activated by glutamate binding, leading to the influx of cations and modulation of postsynaptic membrane potential. 3. **Central nervous system development**: GRIK1 is involved in the development of the CNS, particularly in the formation of synapses and neuronal circuits. 4. **Ionotropic activity of kainate receptors**: GRIK1 receptors exhibit ionotropic activity, allowing the flow of monovalent cations into the cell. **Clinical Significance:** 1. **Neurodevelopmental disorders**: Mutations in the GRIK1 gene have been associated with neurodevelopmental disorders, such as epilepsy and intellectual disability. 2. **Neuropsychiatric disorders**: GRIK1 dysfunction has been implicated in various neuropsychiatric disorders, including schizophrenia, bipolar disorder, and depression. 3. **CNS injury and disease**: GRIK1 receptors may play a role in the pathophysiology of CNS injury and disease, including stroke and traumatic brain injury. 4. **Therapeutic potential**: Targeting GRIK1 receptors may offer a novel therapeutic strategy for the treatment of neurodevelopmental and neuropsychiatric disorders. In conclusion, the GRIK1 gene plays a critical role in the regulation of synaptic transmission and neuronal excitability in the CNS. Further research is needed to fully elucidate the functions and clinical significance of GRIK1 in various diseases and disorders.

Genular Protein ID: 3048166168

Symbol: GRIK1_HUMAN

Name: Glutamate receptor ionotropic, kainate 1

UniProtKB Accession Codes:

P39086 Q13001 Q86SU9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 7 ChEMBL 1 ChiTaRS 1 ComplexPortal 11 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 DrugCentral 1 EMBL 3 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 16 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 11 PDBsum 11 PIR 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 4 Rhea 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8260617

Title: Expression and novel subunit isoforms of glutamate receptor genes GluR5 and GluR6.

PubMed ID: 8260617

DOI: 10.1097/00001756-199309150-00014

PubMed ID: 8589992

Title: cDNA cloning and functional properties of human glutamate receptor EAA3 (GluR5) in homomeric and heteromeric configuration.

PubMed ID: 8589992

PubMed ID: 7696618

Title: RNA editing of human kainate receptor subunits.

PubMed ID: 7696618

DOI: 10.1097/00001756-199412000-00055

PubMed ID: 8730589

Title: Effect of RNA editing and subunit co-assembly single-channel properties of recombinant kainate receptors.

PubMed ID: 8730589

DOI: 10.1113/jphysiol.1996.sp021295

PubMed ID: 21893069

Title: Binding and selectivity of the marine toxin neodysiherbaine A and its synthetic analogues to GluK1 and GluK2 kainate receptors.

PubMed ID: 21893069

DOI: 10.1016/j.jmb.2011.08.043

PubMed ID: 11702055

Title: Association study of polymorphisms in the GluR5 kainate receptor gene (GRIK1) with schizophrenia.

PubMed ID: 11702055

DOI: 10.1097/00041444-200109000-00005

Sequence Information:

  • Length: 918
  • Mass: 103981
  • Checksum: 0EB8DB6356599002
  • Sequence:
    • MEHGTLLAQP GLWTRDTSWA LLYFLCYILP QTAPQVLRIG GIFETVENEP VNVEELAFKF 
AVTSINRNRT LMPNTTLTYD IQRINLFDSF EASRRACDQL ALGVAALFGP SHSSSVSAVQ 
SICNALEVPH IQTRWKHPSV DNKDLFYINL YPDYAAISRA ILDLVLYYNW KTVTVVYEDS 
TGLIRLQELI KAPSRYNIKI KIRQLPSGNK DAKPLLKEMK KGKEFYVIFD CSHETAAEIL 
KQILFMGMMT EYYHYFFTTL DLFALDLELY RYSGVNMTGF RLLNIDNPHV SSIIEKWSME 
RLQAPPRPET GLLDGMMTTE AALMYDAVYM VAIASHRASQ LTVSSLQCHR HKPWRLGPRF 
MNLIKEARWD GLTGHITFNK TNGLRKDFDL DIISLKEEGT EKAAGEVSKH LYKVWKKIGI 
WNSNSGLNMT DSNKDKSSNI TDSLANRTLI VTTILEEPYV MYRKSDKPLY GNDRFEGYCL 
DLLKELSNIL GFIYDVKLVP DGKYGAQNDK GEWNGMVKEL IDHRADLAVA PLTITYVREK 
VIDFSKPFMT LGISILYRKP NGTNPGVFSF LNPLSPDIWM YVLLACLGVS CVLFVIARFT 
PYEWYNPHPC NPDSDVVENN FTLLNSFWFG VGALMQQGSE LMPKALSTRI VGGIWWFFTL 
IIISSYTANL AAFLTVERME SPIDSADDLA KQTKIEYGAV RDGSTMTFFK KSKISTYEKM 
WAFMSSRQQT ALVRNSDEGI QRVLTTDYAL LMESTSIEYV TQRNCNLTQI GGLIDSKGYG 
VGTPIGSPYR DKITIAILQL QEEGKLHMMK EKWWRGNGCP EEDNKEASAL GVENIGGIFI 
VLAAGLVLSV FVAIGEFIYK SRKNNDIEQA FCFFYGLQCK QTHPTNSTSG TTLSTDLECG 
KLIREERGIR KQSSVHTV

Genular Protein ID: 621427626

Symbol: B7Z256_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z256

Database IDs:

ARBA 12 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 7 Gene3D 3 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 1 Pfam 3 RefSeq 1 RuleBase 1 SMART 2 SUPFAM 2

Sequence Information:

  • Length: 748
  • Mass: 84380
  • Checksum: 5968D061F7B81698
  • Sequence:
    • MEHGTLLAQP GLWTRDTSWA LLYFLCYILP QTAPQVLRIA CDQLALGVAA LFGPSHSSSV 
SAVQSICNAL EVPHIQTRWK HPSVDNKDLF YINLYPDYAA ISRAILDLVL YYNWKTVTVV 
YEDSTGLIRL QELIKAPSRY NIKIKIRQLP SGNKDAKPLL KEMKKGKEFY VIFDCSHETA 
AEILKQILFM GMMTEYYHYF FTTLDLFALD LELYRYSGVN MTGFRLLNID NPHVSSIIEK 
WSMERLQAPP RPETGLLDGM MTTEAALMYD AVYMVAIASH RASQLTVSSL QCHRHKPWRL 
GPRFMNLIKE ARWDGLTGHI TFNKTNGLRK DFDLDIISLK EEGTEKIGIW NSNSGLNMTD 
SNKDKSSNIT DSLANRTLIV TTILRADLAV APLTITYVRE KVIDFSKPFM TLGISILYRK 
PNGTNPGVFS FLNPLSPDIW MYVLLACLGV SCVLFVIARF TPYEWYNPHP CNPDSDVVEN 
NFTLLNSFWF GVGALMRQGS ELMPKALSTR IVGGIWWFFT LIIISSYTAN LAAFLTVERM 
ESPIDSADDL AKQTKIEYGA VRDGSTMTFF KKSKISTYEK MWAFMSSRQQ TAPVRNSDEG 
IQRVLTTDYA LLMESTSIEY VTQRNCNLTQ IGGLIDSKGY GVGTPIGSPY RDKITIAILQ 
LQEEGKLHMM KEKWWRGNGC PEEGNKEASA LGVENIGGIF IVLAAGLVLS VFVAIGEFIY 
KSRKNNDIEQ CLSFNAIMEE LGISLKNQ

Genular Protein ID: 2801813640

Symbol: E9PD61_HUMAN

Name: N/A

UniProtKB Accession Codes:

E9PD61

Database IDs:

ARBA 12 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 2 ExpressionAtlas 1 GO 6 Gene3D 3 GeneTree 1 HGNC 1 InterPro 6 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 2 Pfam 3 Proteomes 2 ProteomicsDB 2 RefSeq 1 RuleBase 1 SMART 4 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 920
  • Mass: 104357
  • Checksum: EB4E4517F28A5FBF
  • Sequence:
    • MEHGTLLAQP GLWTRDTSWA LLYFLCYILP QTAPQVLRIG GIFETVENEP VNVEELAFKF 
AVTSINRNRT LMPNTTLTYD IQRINLFDSF EASRRACDQL ALGVAALFGP SHSSSVSAVQ 
SICNALEVPH IQTRWKHPSV DNKDLFYINL YPDYAAISRA ILDLVLYYNW KTVTVVYEDS 
TGLIRLQELI KAPSRYNIKI KIRQLPSGNK DAKPLLKEMK KGKEFYVIFD CSHETAAEIL 
KQILFMGMMT EYYHYFFTTL DLFALDLELY RYSGVNMTGF RLLNIDNPHV SSIIEKWSME 
RLQAPPRPET GLLDGMMTTE AALMYDAVYM VAIASHRASQ LTVSSLQCHR HKPWRLGPRF 
MNLIKEARWD GLTGHITFNK TNGLRKDFDL DIISLKEEGT EKAAGEVSKH LYKVWKKIGI 
WNSNSGLNMT DSNKDKSSNI TDSLANRTLI VTTILEEPYV MYRKSDKPLY GNDRFEGYCL 
DLLKELSNIL GFIYDVKLVP DGKYGAQNDK GEWNGMVKEL IDHRADLAVA PLTITYVREK 
VIDFSKPFMT LGISILYRKP NGTNPGVFSF LNPLSPDIWM YVLLACLGVS CVLFVIARFT 
PYEWYNPHPC NPDSDVVENN FTLLNSFWFG VGALMQQGSE LMPKALSTRI VGGIWWFFTL 
IIISSYTANL AAFLTVERME SPIDSADDLA KQTKIEYGAV RDGSTMTFFK KSKISTYEKM 
WAFMSSRQQT ALVRNSDEGI QRVLTTDYAL LMESTSIEYV TQRNCNLTQI GGLIDSKGYG 
VGTPIGSPYR DKITIAILQL QEEGKLHMMK EKWWRGNGCP EEDNKEASAL GVENIGGIFI 
VLAAGLVLSV FVAIGEFIYK SRKNNDIEQC LSFNAIMEEL GISLKNQKKI KKKSRTKGKS 
SFTSILTCHQ RRTQRKETVA

Genular Protein ID: 2981255520

Symbol: B7Z3V7_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z3V7

Database IDs:

ARBA 12 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 4 Gene3D 3 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 1 Pfam 3 RefSeq 3 RuleBase 1 SMART 4 SUPFAM 2

Sequence Information:

  • Length: 920
  • Mass: 104351
  • Checksum: BAE4AFB855230327
  • Sequence:
    • MEHGTLLAQP GLWTRDTSWA LLYFLCYILP QTAPQVLRIG GIFETVENEP VNVEELAFKF 
AVTSINRNRT LMPNTTLTYD IQRINLFDSF EASRRACDQL ALGVAALFGP SHSSSVSAVQ 
SICNALEVPH IQTRWKHPSV DNKDLFYINL YPDYAAISRA ILDLVLYYNW KTVTVVYEDS 
TGLIRLQELI KAPSRYNIKI KIRQLPSGNK DAKPLLKEMK KGKEFYVIFD CSHETAAEIL 
KQILFMGMMT EYYHYFFTTL DLFALDLELY RYSGVNMTGF RLLNIDNPHV SSIIEKWSME 
RLQAPPRPET GLLDGMMTTE AALMYDAVYM VAIASHRASQ LTVSSLQCHR HKPWRLGPRF 
MNLIKEARWD GLTGHITFNK TNGLRKDFDL DIISLKEEGT EKAAGEVSKH LYKVWKKIGI 
WNSNSGLNMT DSNKDKSSNI TDSLANRTLI VTTILEEPYV MYRKSDKPLY GNDRFEGYCL 
DLLKELSNIL GFIYDVKLVP DGKYGAQNDK GEWNGMVKEL IDHRADLAVA PLTITYVREK 
VIDFSKPFMT LGISILYRKP NGTNPGVFSF LNPLSPDIWM YVLLACLGVS CVLFVIARFT 
PYEWYNPHPC NPDSDVVENN FTLLNSFWFG VGALMRQGSE LMPKALSTRI VGGIWWFFTL 
IIISSYTANL AAFLTVERME SPIDSADDLA KQTKIEYGAV RDGSTMTLFK KSKISTYEKM 
WAFMSSRQQT ALVRNSDEGI QRVLTTDYAL LMESTSIEYV TQRNCNLTQI GGLIDSKGYG 
VGTPIGSPYR DKITIAILQL QEEGKLHMMK EKWWRGNGCP EEDNKEASAL GVENIGGIFI 
VLAAGLVLSV FVAIGEFIYK SRKNNDIEQC LSFNAIMEEL GISLKNQKKI KKKSRTKGKS 
SFTSILTCHQ RRTQRKETVA

Genular Protein ID: 1499476569

Symbol: E7EPY9_HUMAN

Name: N/A

UniProtKB Accession Codes:

E7EPY9

Database IDs:

ARBA 12 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 3 GeneTree 1 HGNC 1 InterPro 6 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 2 Pfam 3 Proteomes 2 ProteomicsDB 2 RefSeq 1 RuleBase 1 SMART 4 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 934
  • Mass: 106151
  • Checksum: 603CAEE6E9EEBD10
  • Sequence:
    • MEHGTLLAQP GLWTRDTSWA LLYFLCYILP QTAPQVLRIG GIFETVENEP VNVEELAFKF 
AVTSINRNRT LMPNTTLTYD IQRINLFDSF EASRRACDQL ALGVAALFGP SHSSSVSAVQ 
SICNALEVPH IQTRWKHPSV DNKDLFYINL YPDYAAISRA ILDLVLYYNW KTVTVVYEDS 
TGLIRLQELI KAPSRYNIKI KIRQLPSGNK DAKPLLKEMK KGKEFYVIFD CSHETAAEIL 
KQILFMGMMT EYYHYFFTTL DLFALDLELY RYSGVNMTGF RLLNIDNPHV SSIIEKWSME 
RLQAPPRPET GLLDGMMTTE AALMYDAVYM VAIASHRASQ LTVSSLQCHR HKPWRLGPRF 
MNLIKEARWD GLTGHITFNK TNGLRKDFDL DIISLKEEGT EKIGIWNSNS GLNMTDSNKD 
KSSNITDSLA NRTLIVTTIL EEPYVMYRKS DKPLYGNDRF EGYCLDLLKE LSNILGFIYD 
VKLVPDGKYG AQNDKGEWNG MVKELIDHRA DLAVAPLTIT YVREKVIDFS KPFMTLGISI 
LYRKPNGTNP GVFSFLNPLS PDIWMYVLLA CLGVSCVLFV IARFTPYEWY NPHPCNPDSD 
VVENNFTLLN SFWFGVGALM QQGSELMPKA LSTRIVGGIW WFFTLIIISS YTANLAAFLT 
VERMESPIDS ADDLAKQTKI EYGAVRDGST MTFFKKSKIS TYEKMWAFMS SRQQTALVRN 
SDEGIQRVLT TDYALLMEST SIEYVTQRNC NLTQIGGLID SKGYGVGTPI GSPYRDKITI 
AILQLQEEGK LHMMKEKWWR GNGCPEEDNK EASALGVENI GGIFIVLAAG LVLSVFVAIG 
EFIYKSRKNN DIEQKGKSSR IRFYFRNKVR FHGRKKQSLG VEKCLSFNAI MEELGISLKN 
QKKIKKKSRT KGKSSFTSIL TCHQRRTQRK ETVA

Genular Protein ID: 2653152638

Symbol: E7ENK3_HUMAN

Name: N/A

UniProtKB Accession Codes:

E7ENK3

Database IDs:

ARBA 12 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 2 ExpressionAtlas 1 GO 6 Gene3D 3 GeneTree 1 HGNC 1 InterPro 6 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 2 Pfam 3 PhylomeDB 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 RuleBase 1 SMART 4 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 949
  • Mass: 107877
  • Checksum: 789FFDC10F544395
  • Sequence:
    • MEHGTLLAQP GLWTRDTSWA LLYFLCYILP QTAPQVLRIG GIFETVENEP VNVEELAFKF 
AVTSINRNRT LMPNTTLTYD IQRINLFDSF EASRRACDQL ALGVAALFGP SHSSSVSAVQ 
SICNALEVPH IQTRWKHPSV DNKDLFYINL YPDYAAISRA ILDLVLYYNW KTVTVVYEDS 
TGLIRLQELI KAPSRYNIKI KIRQLPSGNK DAKPLLKEMK KGKEFYVIFD CSHETAAEIL 
KQILFMGMMT EYYHYFFTTL DLFALDLELY RYSGVNMTGF RLLNIDNPHV SSIIEKWSME 
RLQAPPRPET GLLDGMMTTE AALMYDAVYM VAIASHRASQ LTVSSLQCHR HKPWRLGPRF 
MNLIKEARWD GLTGHITFNK TNGLRKDFDL DIISLKEEGT EKAAGEVSKH LYKVWKKIGI 
WNSNSGLNMT DSNKDKSSNI TDSLANRTLI VTTILEEPYV MYRKSDKPLY GNDRFEGYCL 
DLLKELSNIL GFIYDVKLVP DGKYGAQNDK GEWNGMVKEL IDHRADLAVA PLTITYVREK 
VIDFSKPFMT LGISILYRKP NGTNPGVFSF LNPLSPDIWM YVLLACLGVS CVLFVIARFT 
PYEWYNPHPC NPDSDVVENN FTLLNSFWFG VGALMQQGSE LMPKALSTRI VGGIWWFFTL 
IIISSYTANL AAFLTVERME SPIDSADDLA KQTKIEYGAV RDGSTMTFFK KSKISTYEKM 
WAFMSSRQQT ALVRNSDEGI QRVLTTDYAL LMESTSIEYV TQRNCNLTQI GGLIDSKGYG 
VGTPIGSPYR DKITIAILQL QEEGKLHMMK EKWWRGNGCP EEDNKEASAL GVENIGGIFI 
VLAAGLVLSV FVAIGEFIYK SRKNNDIEQK GKSSRIRFYF RNKVRFHGRK KQSLGVEKCL 
SFNAIMEELG ISLKNQKKIK KKSRTKGKSS FTSILTCHQR RTQRKETVA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.