Details for: SRPK3

Gene ID: 26576

Symbol: SRPK3

Ensembl ID: ENSG00000184343

Description: SRSF protein kinase 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 18.9242
    Cell Significance Index: -4.8000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 3.2027
    Cell Significance Index: 196.3600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.7272
    Cell Significance Index: 55.3200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 1.3541
    Cell Significance Index: 33.0400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.9902
    Cell Significance Index: 188.4500
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 0.8931
    Cell Significance Index: 14.4100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6514
    Cell Significance Index: 64.4400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.6175
    Cell Significance Index: 13.1500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5248
    Cell Significance Index: 473.8900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3976
    Cell Significance Index: 30.5200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3471
    Cell Significance Index: 20.8400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3411
    Cell Significance Index: 55.4700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.2303
    Cell Significance Index: 5.9200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1967
    Cell Significance Index: 13.6100
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.1632
    Cell Significance Index: 2.2000
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.1552
    Cell Significance Index: 1.6200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0610
    Cell Significance Index: 0.9000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0555
    Cell Significance Index: 1.9500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0532
    Cell Significance Index: 2.4800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0318
    Cell Significance Index: 1.4400
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 0.0280
    Cell Significance Index: 0.0200
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.0274
    Cell Significance Index: 0.4000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0226
    Cell Significance Index: 4.5300
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.0168
    Cell Significance Index: 0.2200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0091
    Cell Significance Index: 6.3100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0083
    Cell Significance Index: 0.2400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0030
    Cell Significance Index: 1.3700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0018
    Cell Significance Index: 0.6600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0008
    Cell Significance Index: -0.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0020
    Cell Significance Index: -3.7600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0023
    Cell Significance Index: -4.2000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0025
    Cell Significance Index: -3.8400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0032
    Cell Significance Index: -0.1700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0037
    Cell Significance Index: -4.9900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0055
    Cell Significance Index: -0.2400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0063
    Cell Significance Index: -0.1300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0067
    Cell Significance Index: -5.0800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0070
    Cell Significance Index: -5.2200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0071
    Cell Significance Index: -0.4600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0071
    Cell Significance Index: -4.4400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.0071
    Cell Significance Index: -0.0600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0082
    Cell Significance Index: -5.2200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0083
    Cell Significance Index: -4.5100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0084
    Cell Significance Index: -4.7400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0088
    Cell Significance Index: -1.2100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0111
    Cell Significance Index: -0.2400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0173
    Cell Significance Index: -4.9700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0179
    Cell Significance Index: -0.2700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0186
    Cell Significance Index: -3.6900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0191
    Cell Significance Index: -3.4500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0253
    Cell Significance Index: -5.3300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0255
    Cell Significance Index: -3.2900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0255
    Cell Significance Index: -4.3500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0265
    Cell Significance Index: -1.6700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0265
    Cell Significance Index: -1.3400
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0274
    Cell Significance Index: -0.4100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0288
    Cell Significance Index: -4.1900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0314
    Cell Significance Index: -1.2900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0337
    Cell Significance Index: -3.9300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0339
    Cell Significance Index: -4.1700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0349
    Cell Significance Index: -0.7400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0402
    Cell Significance Index: -4.6100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0424
    Cell Significance Index: -4.4200
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0492
    Cell Significance Index: -0.7800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0505
    Cell Significance Index: -1.4100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0529
    Cell Significance Index: -5.4000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0643
    Cell Significance Index: -3.3400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0705
    Cell Significance Index: -1.9200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0712
    Cell Significance Index: -4.7900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0721
    Cell Significance Index: -1.5100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0742
    Cell Significance Index: -5.5300
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0749
    Cell Significance Index: -0.9600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0763
    Cell Significance Index: -0.8300
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0766
    Cell Significance Index: -0.9900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0766
    Cell Significance Index: -1.1300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0781
    Cell Significance Index: -4.8000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0836
    Cell Significance Index: -4.6900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0867
    Cell Significance Index: -1.7400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0889
    Cell Significance Index: -4.1800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0892
    Cell Significance Index: -2.1600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0893
    Cell Significance Index: -4.6500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0915
    Cell Significance Index: -1.3100
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0962
    Cell Significance Index: -1.3300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1033
    Cell Significance Index: -3.6200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1082
    Cell Significance Index: -1.8100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1101
    Cell Significance Index: -4.8700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1126
    Cell Significance Index: -2.3500
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1149
    Cell Significance Index: -1.4500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1151
    Cell Significance Index: -3.0800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1199
    Cell Significance Index: -2.0600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1216
    Cell Significance Index: -3.9800
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1233
    Cell Significance Index: -1.6000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1242
    Cell Significance Index: -3.9600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1265
    Cell Significance Index: -4.7900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1426
    Cell Significance Index: -3.7500
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1427
    Cell Significance Index: -2.0300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1474
    Cell Significance Index: -5.4100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1480
    Cell Significance Index: -3.7700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1485
    Cell Significance Index: -5.1600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1492
    Cell Significance Index: -2.5800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Serine/threonine kinase activity**: SRPK3 possesses serine/threonine kinase activity, which allows it to phosphorylate and regulate the activity of other proteins. 2. **Spliceosomal complex assembly**: SRPK3 is essential for the assembly of spliceosomal complexes, which are responsible for the splicing of pre-mRNA into mature mRNA. 3. **RNA processing regulation**: SRPK3 regulates RNA processing by phosphorylating and activating or inhibiting various RNA processing factors. 4. **Cellular differentiation**: SRPK3 is involved in the regulation of cellular differentiation, particularly in muscle tissue development and the development of neural cells. 5. **Muscle tissue development**: SRPK3 plays a crucial role in the development of skeletal muscle tissue. **Pathways and Functions:** SRPK3 is involved in several signaling pathways, including: 1. **Intracellular signal transduction**: SRPK3 is activated by various signaling molecules, including PKA and MAPK, and regulates the activity of downstream targets. 2. **Peptidyl-serine phosphorylation**: SRPK3 phosphorylates serine residues on target proteins, which can alter their activity or subcellular localization. 3. **Protein binding**: SRPK3 interacts with various proteins, including RNA processing factors and transcription factors, to regulate their activity. 4. **Regulation of mRNA processing**: SRPK3 regulates the splicing of pre-mRNA into mature mRNA, which is essential for gene expression and cellular function. **Clinical Significance:** Dysregulation of SRPK3 has been implicated in various diseases, including: 1. **Cancer**: SRPK3 is overexpressed in certain types of cancer, including breast and lung cancer, and is associated with poor prognosis. 2. **Neurodegenerative disorders**: SRPK3 is involved in the development of neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease. 3. **Muscle disorders**: SRPK3 is involved in the development of muscle disorders, including muscular dystrophy and myasthenia gravis. In conclusion, SRPK3 is a critical regulator of RNA processing, cellular differentiation, and muscle tissue development. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms of SRPK3 and its role in human disease.

Genular Protein ID: 826582502

Symbol: SRPK3_HUMAN

Name: SRSF protein kinase 3

UniProtKB Accession Codes:

Q9UPE1 Q13583 Q4F970 Q562F5 Q9UM62

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugCentral 1 EC 3 EMBL 7 Ensembl 3 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 ProteomicsDB 4 RNAct 1 RefSeq 3 Rhea 6 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11063724

Title: Large-scale methylation analysis of human genomic DNA reveals tissue-specific differences between the methylation profiles of genes and pseudogenes.

PubMed ID: 11063724

DOI: 10.1093/hmg/9.18.2651

PubMed ID: 21205200

Title: Serine-arginine protein kinases: a small protein kinase family with a large cellular presence.

PubMed ID: 21205200

DOI: 10.1111/j.1742-4658.2010.07987.x

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 567
  • Mass: 62014
  • Checksum: 754A9F3759ADEE82
  • Sequence:
    • MSASTGGGGD SGGSGGSSSS SQASCGPESS GSELALATPV PQMLQGLLGS DDEEQEDPKD 
YCKGGYHPVK IGDVFNGRYH VVRKLGWGHF STVWLCWDIQ RKRFVALKVV KSAGHYTETA 
VDEIKLLKCV RDSDPSDPKR ETIVQLIDDF RISGVNGVHV CMVLEVLGHQ LLKWIIKSNY 
QGLPVPCVKS IVRQVLHGLD YLHTKCKIIH TDIKPENILL CVGDAYIRRL AAEATEWQQA 
GAPPPSRSIV STAPQEVLQT GKLSKNKRKK MRRKRKQQKR LLEERLRDLQ RLEAMEAATQ 
AEDSGLRLDG GSGSTSSSGC HPGGARAGPS PASSSPAPGG GRSLSAGSQT SGFSGSLFSP 
ASCSILSGSS NQRETGGLLS PSTPFGASNL LVNPLEPQNA DKIKIKIADL GNACWVHKHF 
TEDIQTRQYR AVEVLIGAEY GPPADIWSTA CMAFELATGD YLFEPHSGED YSRDEDHIAH 
IVELLGDIPP AFALSGRYSR EFFNRRGELR HIHNLKHWGL YEVLMEKYEW PLEQATQFSA 
FLLPMMEYIP EKRASAADCL QHPWLNP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.