CL0002605 - astrocyte of the cerebral cortex details

Details for: CL0002605

Cell ID: CL0002605

Cell Name: astrocyte of the cerebral cortex

Marker Score Threshold: 21343
(Derived using integrated single-cell and genomic data)

Description: A transcriptomically distinct astrocyte that is found in the cerebral cortex.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Gene Symbol: ADGRB3 (ENSG00000135298)
Fold Change: 3.27
Ensembl ID: ENSG00000135298
Gene Symbol: ANK2 (ENSG00000145362)
Fold Change: 3.26
Ensembl ID: ENSG00000145362
Gene Symbol: ADCY2 (ENSG00000078295)
Fold Change: 3.26
Ensembl ID: ENSG00000078295
Gene Symbol: ATP1A2 (ENSG00000018625)
Fold Change: 3.18
Ensembl ID: ENSG00000018625
Gene Symbol: APC (ENSG00000134982)
Fold Change: 3.14
Ensembl ID: ENSG00000134982
Gene Symbol: ASPH (ENSG00000198363)
Fold Change: 3.13
Ensembl ID: ENSG00000198363
Gene Symbol: RERE (ENSG00000142599)
Fold Change: 3.09
Ensembl ID: ENSG00000142599
Gene Symbol: ADD3 (ENSG00000148700)
Fold Change: 3.09
Ensembl ID: ENSG00000148700
Gene Symbol: AQP4 (ENSG00000171885)
Fold Change: 2.99
Ensembl ID: ENSG00000171885
Gene Symbol: ARHGAP5 (ENSG00000100852)
Fold Change: 2.97
Ensembl ID: ENSG00000100852
Gene Symbol: ACACB (ENSG00000076555)
Fold Change: 2.97
Ensembl ID: ENSG00000076555
Gene Symbol: ABR (ENSG00000159842)
Fold Change: 2.92
Ensembl ID: ENSG00000159842
Gene Symbol: BCKDHB (ENSG00000083123)
Fold Change: 2.86
Ensembl ID: ENSG00000083123
Gene Symbol: ATP2B4 (ENSG00000058668)
Fold Change: 2.81
Ensembl ID: ENSG00000058668
Gene Symbol: ZFHX3 (ENSG00000140836)
Fold Change: 2.78
Ensembl ID: ENSG00000140836
Gene Symbol: ACYP2 (ENSG00000170634)
Fold Change: 2.75
Ensembl ID: ENSG00000170634
Gene Symbol: ASTN1 (ENSG00000152092)
Fold Change: 2.74
Ensembl ID: ENSG00000152092
Gene Symbol: ADD1 (ENSG00000087274)
Fold Change: 2.68
Ensembl ID: ENSG00000087274
Gene Symbol: ATRX (ENSG00000085224)
Fold Change: 2.58
Ensembl ID: ENSG00000085224
Gene Symbol: ATP2B2 (ENSG00000157087)
Fold Change: 2.54
Ensembl ID: ENSG00000157087
Gene Symbol: BBS2 (ENSG00000125124)
Fold Change: 2.53
Ensembl ID: ENSG00000125124
Gene Symbol: ATP1B2 (ENSG00000129244)
Fold Change: 2.51
Ensembl ID: ENSG00000129244
Gene Symbol: ACACA (ENSG00000278540)
Fold Change: 2.47
Ensembl ID: ENSG00000278540
Gene Symbol: ALCAM (ENSG00000170017)
Fold Change: 2.44
Ensembl ID: ENSG00000170017
Gene Symbol: ADCY8 (ENSG00000155897)
Fold Change: 2.42
Ensembl ID: ENSG00000155897
Gene Symbol: ADK (ENSG00000156110)
Fold Change: 2.34
Ensembl ID: ENSG00000156110
Gene Symbol: ABCA1 (ENSG00000165029)
Fold Change: 2.33
Ensembl ID: ENSG00000165029
Gene Symbol: ALDH7A1 (ENSG00000164904)
Fold Change: 2.32
Ensembl ID: ENSG00000164904
Gene Symbol: ADRA1A (ENSG00000120907)
Fold Change: 2.25
Ensembl ID: ENSG00000120907
Gene Symbol: APOE (ENSG00000130203)
Fold Change: 2.2
Ensembl ID: ENSG00000130203
Gene Symbol: AUH (ENSG00000148090)
Fold Change: 2.18
Ensembl ID: ENSG00000148090
Gene Symbol: ARRB1 (ENSG00000137486)
Fold Change: 2.04
Ensembl ID: ENSG00000137486
Gene Symbol: GRK3 (ENSG00000100077)
Fold Change: 2.03
Ensembl ID: ENSG00000100077
Gene Symbol: ALDH2 (ENSG00000111275)
Fold Change: 2.02
Ensembl ID: ENSG00000111275
Gene Symbol: ABL1 (ENSG00000097007)
Fold Change: 2.01
Ensembl ID: ENSG00000097007
Gene Symbol: ADAM10 (ENSG00000137845)
Fold Change: 1.99
Ensembl ID: ENSG00000137845
Gene Symbol: ADCY9 (ENSG00000162104)
Fold Change: 1.95
Ensembl ID: ENSG00000162104
Gene Symbol: KIF1A (ENSG00000130294)
Fold Change: 1.92
Ensembl ID: ENSG00000130294
Gene Symbol: APBA2 (ENSG00000034053)
Fold Change: 1.89
Ensembl ID: ENSG00000034053
Gene Symbol: AP2B1 (ENSG00000006125)
Fold Change: 1.89
Ensembl ID: ENSG00000006125
Gene Symbol: ATP2A2 (ENSG00000174437)
Fold Change: 1.88
Ensembl ID: ENSG00000174437
Gene Symbol: AGT (ENSG00000135744)
Fold Change: 1.87
Ensembl ID: ENSG00000135744
Gene Symbol: ACO2 (ENSG00000100412)
Fold Change: 1.82
Ensembl ID: ENSG00000100412
Gene Symbol: BCAT2 (ENSG00000105552)
Fold Change: 1.82
Ensembl ID: ENSG00000105552
Gene Symbol: APP (ENSG00000142192)
Fold Change: 1.8
Ensembl ID: ENSG00000142192
Gene Symbol: ATP6V0A1 (ENSG00000033627)
Fold Change: 1.77
Ensembl ID: ENSG00000033627
Gene Symbol: ABL2 (ENSG00000143322)
Fold Change: 1.76
Ensembl ID: ENSG00000143322
Gene Symbol: ABAT (ENSG00000183044)
Fold Change: 1.76
Ensembl ID: ENSG00000183044
Gene Symbol: APBA1 (ENSG00000107282)
Fold Change: 1.74
Ensembl ID: ENSG00000107282
Gene Symbol: ACADVL (ENSG00000072778)
Fold Change: 1.69
Ensembl ID: ENSG00000072778
Gene Symbol: ATM (ENSG00000149311)
Fold Change: 1.68
Ensembl ID: ENSG00000149311
Gene Symbol: BMAL1 (ENSG00000133794)
Fold Change: 1.65
Ensembl ID: ENSG00000133794
Gene Symbol: ALDH1A1 (ENSG00000165092)
Fold Change: 1.64
Ensembl ID: ENSG00000165092
Gene Symbol: ADCYAP1R1 (ENSG00000078549)
Fold Change: 1.64
Ensembl ID: ENSG00000078549
Gene Symbol: ANXA4 (ENSG00000196975)
Fold Change: 1.62
Ensembl ID: ENSG00000196975
Gene Symbol: AKT2 (ENSG00000105221)
Fold Change: 1.61
Ensembl ID: ENSG00000105221
Gene Symbol: AK4 (ENSG00000162433)
Fold Change: 1.61
Ensembl ID: ENSG00000162433
Gene Symbol: AP1G1 (ENSG00000166747)
Fold Change: 1.56
Ensembl ID: ENSG00000166747
Gene Symbol: AGL (ENSG00000162688)
Fold Change: 1.56
Ensembl ID: ENSG00000162688
Gene Symbol: ACTB (ENSG00000075624)
Fold Change: 1.54
Ensembl ID: ENSG00000075624
Gene Symbol: ARL3 (ENSG00000138175)
Fold Change: 1.52
Ensembl ID: ENSG00000138175
Gene Symbol: ALK (ENSG00000171094)
Fold Change: 1.51
Ensembl ID: ENSG00000171094
Gene Symbol: ATP5F1C (ENSG00000165629)
Fold Change: 1.45
Ensembl ID: ENSG00000165629
Gene Symbol: AP2A2 (ENSG00000183020)
Fold Change: 1.44
Ensembl ID: ENSG00000183020
Gene Symbol: ABCD2 (ENSG00000173208)
Fold Change: 1.43
Ensembl ID: ENSG00000173208
Gene Symbol: ATP2B1 (ENSG00000070961)
Fold Change: 1.43
Ensembl ID: ENSG00000070961
Gene Symbol: ATP6V1A (ENSG00000114573)
Fold Change: 1.43
Ensembl ID: ENSG00000114573
Gene Symbol: RHOB (ENSG00000143878)
Fold Change: 1.42
Ensembl ID: ENSG00000143878
Gene Symbol: XIAP (ENSG00000101966)
Fold Change: 1.4
Ensembl ID: ENSG00000101966
Gene Symbol: ADAR (ENSG00000160710)
Fold Change: 1.4
Ensembl ID: ENSG00000160710
Gene Symbol: ADARB2 (ENSG00000185736)
Fold Change: 1.38
Ensembl ID: ENSG00000185736
Gene Symbol: ALDOC (ENSG00000109107)
Fold Change: 1.35
Ensembl ID: ENSG00000109107
Gene Symbol: ACO1 (ENSG00000122729)
Fold Change: 1.34
Ensembl ID: ENSG00000122729
Gene Symbol: ABCA3 (ENSG00000167972)
Fold Change: 1.31
Ensembl ID: ENSG00000167972
Gene Symbol: ACTG1 (ENSG00000184009)
Fold Change: 1.3
Ensembl ID: ENSG00000184009
Gene Symbol: ARNT (ENSG00000143437)
Fold Change: 1.3
Ensembl ID: ENSG00000143437
Gene Symbol: ACTN4 (ENSG00000130402)
Fold Change: 1.29
Ensembl ID: ENSG00000130402
Gene Symbol: ATP1B3 (ENSG00000069849)
Fold Change: 1.28
Ensembl ID: ENSG00000069849
Gene Symbol: ABCB7 (ENSG00000131269)
Fold Change: 1.28
Ensembl ID: ENSG00000131269
Gene Symbol: ATR (ENSG00000175054)
Fold Change: 1.27
Ensembl ID: ENSG00000175054
Gene Symbol: ATP6V1C1 (ENSG00000155097)
Fold Change: 1.22
Ensembl ID: ENSG00000155097
Gene Symbol: APLP2 (ENSG00000084234)
Fold Change: 1.2
Ensembl ID: ENSG00000084234
Gene Symbol: ACVR1 (ENSG00000115170)
Fold Change: 1.18
Ensembl ID: ENSG00000115170
Gene Symbol: AXL (ENSG00000167601)
Fold Change: 1.18
Ensembl ID: ENSG00000167601
Gene Symbol: ADCY3 (ENSG00000138031)
Fold Change: 1.17
Ensembl ID: ENSG00000138031
Gene Symbol: ANK3 (ENSG00000151150)
Fold Change: 1.17
Ensembl ID: ENSG00000151150
Gene Symbol: APBB2 (ENSG00000163697)
Fold Change: 1.14
Ensembl ID: ENSG00000163697
Gene Symbol: ACADM (ENSG00000117054)
Fold Change: 1.14
Ensembl ID: ENSG00000117054
Gene Symbol: ACTN1 (ENSG00000072110)
Fold Change: 1.12
Ensembl ID: ENSG00000072110
Gene Symbol: AP1B1 (ENSG00000100280)
Fold Change: 1.1
Ensembl ID: ENSG00000100280
Gene Symbol: ANXA7 (ENSG00000138279)
Fold Change: 1.06
Ensembl ID: ENSG00000138279
Gene Symbol: ATP5ME (ENSG00000169020)
Fold Change: 1.05
Ensembl ID: ENSG00000169020
Gene Symbol: ARHGAP1 (ENSG00000175220)
Fold Change: 1.05
Ensembl ID: ENSG00000175220
Gene Symbol: SHROOM2 (ENSG00000146950)
Fold Change: 1.04
Ensembl ID: ENSG00000146950
Gene Symbol: ADORA2B (ENSG00000170425)
Fold Change: 1.04
Ensembl ID: ENSG00000170425
Gene Symbol: AMY2B (ENSG00000240038)
Fold Change: 1.04
Ensembl ID: ENSG00000240038
Gene Symbol: ACADSB (ENSG00000196177)
Fold Change: 1.03
Ensembl ID: ENSG00000196177
Gene Symbol: ATP5MC2 (ENSG00000135390)
Fold Change: 1.02
Ensembl ID: ENSG00000135390
Gene Symbol: PARP4 (ENSG00000102699)
Fold Change: 1.01
Ensembl ID: ENSG00000102699
Gene Symbol: AMFR (ENSG00000159461)
Fold Change: 1
Ensembl ID: ENSG00000159461

Gene representation (4104)
Gene/Pathway representation (4104)

Hovered Details

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Hovered Details

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**Key Characteristics** * **Transcriptomically distinct**: The astrocyte has a unique gene expression profile compared to other astrocytes and neurons. * **ADGRB3**: The gene ADGRB3 is involved in adenylate cyclase-activating g protein-coupled receptor signaling pathway, which plays a role in regulating the concentration of ions and neurotransmitters. * **ANK2**: The gene ANK2 is involved in various cellular processes, including protein binding, localization, and transport. It is also involved in regulating the concentration of ions and neurotransmitters. * **ADCY2**: The gene ADCY2 is involved in adenylate cyclase-activating g protein-coupled receptor signaling pathway, which plays a role in regulating the concentration of ions and neurotransmitters. **Clinical Significance** * **Neurological disorders**: The astrocyte plays a crucial role in maintaining the health and function of the brain. Dysregulation of the astrocyte's function has been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. * **Stroke and traumatic brain injury**: The astrocyte's role in regulating the concentration of ions and neurotransmitters makes it a potential target for treatment of stroke and traumatic brain injury. * **Neurodevelopmental disorders**: The astrocyte's role in regulating the concentration of ions and neurotransmitters makes it a potential target for treatment of neurodevelopmental disorders, such as autism and schizophrenia. * **Cancer**: The astrocyte's role in regulating the concentration of ions and neurotransmitters makes it a potential target for treatment of cancer, particularly glioblastoma. **Pathways and Ontologies** * **Adenylate cyclase-activating g protein-coupled receptor signaling pathway**: This pathway is involved in regulating the concentration of ions and neurotransmitters. * **Cell surface receptor signaling pathway**: This pathway is involved in regulating the concentration of ions and neurotransmitters. * **Cerebellar climbing fiber to Purkinje cell synapse**: This pathway is involved in regulating the concentration of ions and neurotransmitters. * **G protein-coupled receptor activity**: This pathway is involved in regulating the concentration of ions and neurotransmitters. * **GTPase activator activity**: This pathway is involved in regulating the concentration of ions and neurotransmitters. **Gene Symbol and Ensembl ID** * **ADGRB3**: Gene Symbol, ADGRB3; Ensembl ID, ENSG00000135298 * **ANK2**: Gene Symbol, ANK2; Ensembl ID, ENSG00000145362 * **ADCY2**: Gene Symbol, ADCY2; Ensembl ID, ENSG00000078295

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.