Details for: CL0002605

Cell ID: CL0002605

Cell Name: astrocyte of the cerebral cortex

Marker Score Threshold: 21,343
(Derived using integrated single-cell and genomic data)

Description: A transcriptomically distinct astrocyte that is found in the cerebral cortex.

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: CTNND2 (ENSG00000169862)
    Fold Change: 3.28
    Ensembl ID: ENSG00000169862
  • Gene Symbol: DTNA (ENSG00000134769)
    Fold Change: 3.27
    Ensembl ID: ENSG00000134769
  • Gene Symbol: GPM6A (ENSG00000150625)
    Fold Change: 3.27
    Ensembl ID: ENSG00000150625
  • Gene Symbol: CTNNA2 (ENSG00000066032)
    Fold Change: 3.27
    Ensembl ID: ENSG00000066032
  • Gene Symbol: ADGRB3 (ENSG00000135298)
    Fold Change: 3.27
    Ensembl ID: ENSG00000135298
  • Gene Symbol: ERBB4 (ENSG00000178568)
    Fold Change: 3.27
    Ensembl ID: ENSG00000178568
  • Gene Symbol: ANK2 (ENSG00000145362)
    Fold Change: 3.26
    Ensembl ID: ENSG00000145362
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 3.26
    Ensembl ID: ENSG00000151914
  • Gene Symbol: ADCY2 (ENSG00000078295)
    Fold Change: 3.26
    Ensembl ID: ENSG00000078295
  • Gene Symbol: GPC5 (ENSG00000179399)
    Fold Change: 3.24
    Ensembl ID: ENSG00000179399
  • Gene Symbol: DLG2 (ENSG00000150672)
    Fold Change: 3.21
    Ensembl ID: ENSG00000150672
  • Gene Symbol: FYN (ENSG00000010810)
    Fold Change: 3.21
    Ensembl ID: ENSG00000010810
  • Gene Symbol: GABRB1 (ENSG00000163288)
    Fold Change: 3.19
    Ensembl ID: ENSG00000163288
  • Gene Symbol: CNTN1 (ENSG00000018236)
    Fold Change: 3.18
    Ensembl ID: ENSG00000018236
  • Gene Symbol: CLU (ENSG00000120885)
    Fold Change: 3.18
    Ensembl ID: ENSG00000120885
  • Gene Symbol: ATP1A2 (ENSG00000018625)
    Fold Change: 3.18
    Ensembl ID: ENSG00000018625
  • Gene Symbol: GNAQ (ENSG00000156052)
    Fold Change: 3.14
    Ensembl ID: ENSG00000156052
  • Gene Symbol: APC (ENSG00000134982)
    Fold Change: 3.14
    Ensembl ID: ENSG00000134982
  • Gene Symbol: GPM6B (ENSG00000046653)
    Fold Change: 3.14
    Ensembl ID: ENSG00000046653
  • Gene Symbol: CPE (ENSG00000109472)
    Fold Change: 3.13
    Ensembl ID: ENSG00000109472
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 3.13
    Ensembl ID: ENSG00000198363
  • Gene Symbol: FHIT (ENSG00000189283)
    Fold Change: 3.12
    Ensembl ID: ENSG00000189283
  • Gene Symbol: BMPR1B (ENSG00000138696)
    Fold Change: 3.1
    Ensembl ID: ENSG00000138696
  • Gene Symbol: RERE (ENSG00000142599)
    Fold Change: 3.09
    Ensembl ID: ENSG00000142599
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 3.09
    Ensembl ID: ENSG00000148700
  • Gene Symbol: DPYSL2 (ENSG00000092964)
    Fold Change: 3.08
    Ensembl ID: ENSG00000092964
  • Gene Symbol: CACNB2 (ENSG00000165995)
    Fold Change: 3.08
    Ensembl ID: ENSG00000165995
  • Gene Symbol: BCL2 (ENSG00000171791)
    Fold Change: 3.05
    Ensembl ID: ENSG00000171791
  • Gene Symbol: DGKG (ENSG00000058866)
    Fold Change: 3.05
    Ensembl ID: ENSG00000058866
  • Gene Symbol: CAMK2G (ENSG00000148660)
    Fold Change: 3.04
    Ensembl ID: ENSG00000148660
  • Gene Symbol: DOCK3 (ENSG00000088538)
    Fold Change: 2.99
    Ensembl ID: ENSG00000088538
  • Gene Symbol: AQP4 (ENSG00000171885)
    Fold Change: 2.99
    Ensembl ID: ENSG00000171885
  • Gene Symbol: ARHGAP5 (ENSG00000100852)
    Fold Change: 2.97
    Ensembl ID: ENSG00000100852
  • Gene Symbol: ACACB (ENSG00000076555)
    Fold Change: 2.97
    Ensembl ID: ENSG00000076555
  • Gene Symbol: BICD1 (ENSG00000151746)
    Fold Change: 2.95
    Ensembl ID: ENSG00000151746
  • Gene Symbol: DOCK1 (ENSG00000150760)
    Fold Change: 2.95
    Ensembl ID: ENSG00000150760
  • Gene Symbol: ABR (ENSG00000159842)
    Fold Change: 2.92
    Ensembl ID: ENSG00000159842
  • Gene Symbol: FOXO1 (ENSG00000150907)
    Fold Change: 2.91
    Ensembl ID: ENSG00000150907
  • Gene Symbol: FOXN3 (ENSG00000053254)
    Fold Change: 2.91
    Ensembl ID: ENSG00000053254
  • Gene Symbol: HMGB1 (ENSG00000189403)
    Fold Change: 2.89
    Ensembl ID: ENSG00000189403
  • Gene Symbol: BCL6 (ENSG00000113916)
    Fold Change: 2.88
    Ensembl ID: ENSG00000113916
  • Gene Symbol: BMPR1A (ENSG00000107779)
    Fold Change: 2.88
    Ensembl ID: ENSG00000107779
  • Gene Symbol: EYA2 (ENSG00000064655)
    Fold Change: 2.87
    Ensembl ID: ENSG00000064655
  • Gene Symbol: BCKDHB (ENSG00000083123)
    Fold Change: 2.86
    Ensembl ID: ENSG00000083123
  • Gene Symbol: GLI3 (ENSG00000106571)
    Fold Change: 2.85
    Ensembl ID: ENSG00000106571
  • Gene Symbol: CHD2 (ENSG00000173575)
    Fold Change: 2.85
    Ensembl ID: ENSG00000173575
  • Gene Symbol: GRID1 (ENSG00000182771)
    Fold Change: 2.85
    Ensembl ID: ENSG00000182771
  • Gene Symbol: IGF1R (ENSG00000140443)
    Fold Change: 2.84
    Ensembl ID: ENSG00000140443
  • Gene Symbol: CDH4 (ENSG00000179242)
    Fold Change: 2.81
    Ensembl ID: ENSG00000179242
  • Gene Symbol: ATP2B4 (ENSG00000058668)
    Fold Change: 2.81
    Ensembl ID: ENSG00000058668
  • Gene Symbol: FER (ENSG00000151422)
    Fold Change: 2.81
    Ensembl ID: ENSG00000151422
  • Gene Symbol: BPTF (ENSG00000171634)
    Fold Change: 2.81
    Ensembl ID: ENSG00000171634
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 2.8
    Ensembl ID: ENSG00000122545
  • Gene Symbol: GTF2I (ENSG00000263001)
    Fold Change: 2.8
    Ensembl ID: ENSG00000263001
  • Gene Symbol: GNAO1 (ENSG00000087258)
    Fold Change: 2.8
    Ensembl ID: ENSG00000087258
  • Gene Symbol: FUT8 (ENSG00000033170)
    Fold Change: 2.8
    Ensembl ID: ENSG00000033170
  • Gene Symbol: GLUD1 (ENSG00000148672)
    Fold Change: 2.79
    Ensembl ID: ENSG00000148672
  • Gene Symbol: ZFHX3 (ENSG00000140836)
    Fold Change: 2.78
    Ensembl ID: ENSG00000140836
  • Gene Symbol: GLUL (ENSG00000135821)
    Fold Change: 2.76
    Ensembl ID: ENSG00000135821
  • Gene Symbol: ACYP2 (ENSG00000170634)
    Fold Change: 2.75
    Ensembl ID: ENSG00000170634
  • Gene Symbol: CDH2 (ENSG00000170558)
    Fold Change: 2.75
    Ensembl ID: ENSG00000170558
  • Gene Symbol: ASTN1 (ENSG00000152092)
    Fold Change: 2.74
    Ensembl ID: ENSG00000152092
  • Gene Symbol: GJA1 (ENSG00000152661)
    Fold Change: 2.74
    Ensembl ID: ENSG00000152661
  • Gene Symbol: GFAP (ENSG00000131095)
    Fold Change: 2.73
    Ensembl ID: ENSG00000131095
  • Gene Symbol: GRIA2 (ENSG00000120251)
    Fold Change: 2.73
    Ensembl ID: ENSG00000120251
  • Gene Symbol: EPS15 (ENSG00000085832)
    Fold Change: 2.73
    Ensembl ID: ENSG00000085832
  • Gene Symbol: FGFR2 (ENSG00000066468)
    Fold Change: 2.71
    Ensembl ID: ENSG00000066468
  • Gene Symbol: GLG1 (ENSG00000090863)
    Fold Change: 2.7
    Ensembl ID: ENSG00000090863
  • Gene Symbol: DAPK1 (ENSG00000196730)
    Fold Change: 2.7
    Ensembl ID: ENSG00000196730
  • Gene Symbol: EGFR (ENSG00000146648)
    Fold Change: 2.69
    Ensembl ID: ENSG00000146648
  • Gene Symbol: ADD1 (ENSG00000087274)
    Fold Change: 2.68
    Ensembl ID: ENSG00000087274
  • Gene Symbol: ARHGAP35 (ENSG00000160007)
    Fold Change: 2.68
    Ensembl ID: ENSG00000160007
  • Gene Symbol: CSNK1A1 (ENSG00000113712)
    Fold Change: 2.66
    Ensembl ID: ENSG00000113712
  • Gene Symbol: BRAF (ENSG00000157764)
    Fold Change: 2.66
    Ensembl ID: ENSG00000157764
  • Gene Symbol: EFNA5 (ENSG00000184349)
    Fold Change: 2.66
    Ensembl ID: ENSG00000184349
  • Gene Symbol: FKBP5 (ENSG00000096060)
    Fold Change: 2.62
    Ensembl ID: ENSG00000096060
  • Gene Symbol: CACNA1C (ENSG00000151067)
    Fold Change: 2.62
    Ensembl ID: ENSG00000151067
  • Gene Symbol: CHKA (ENSG00000110721)
    Fold Change: 2.62
    Ensembl ID: ENSG00000110721
  • Gene Symbol: GABRA2 (ENSG00000151834)
    Fold Change: 2.61
    Ensembl ID: ENSG00000151834
  • Gene Symbol: LDLRAD4 (ENSG00000168675)
    Fold Change: 2.6
    Ensembl ID: ENSG00000168675
  • Gene Symbol: MEGF9 (ENSG00000106780)
    Fold Change: 2.59
    Ensembl ID: ENSG00000106780
  • Gene Symbol: EPHB1 (ENSG00000154928)
    Fold Change: 2.58
    Ensembl ID: ENSG00000154928
  • Gene Symbol: GABBR1 (ENSG00000204681)
    Fold Change: 2.58
    Ensembl ID: ENSG00000204681
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 2.58
    Ensembl ID: ENSG00000085224
  • Gene Symbol: BMPR2 (ENSG00000204217)
    Fold Change: 2.58
    Ensembl ID: ENSG00000204217
  • Gene Symbol: DYRK1A (ENSG00000157540)
    Fold Change: 2.57
    Ensembl ID: ENSG00000157540
  • Gene Symbol: FOXO3 (ENSG00000118689)
    Fold Change: 2.56
    Ensembl ID: ENSG00000118689
  • Gene Symbol: CUX1 (ENSG00000257923)
    Fold Change: 2.55
    Ensembl ID: ENSG00000257923
  • Gene Symbol: ESRRG (ENSG00000196482)
    Fold Change: 2.55
    Ensembl ID: ENSG00000196482
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 2.55
    Ensembl ID: ENSG00000143933
  • Gene Symbol: LRBA (ENSG00000198589)
    Fold Change: 2.54
    Ensembl ID: ENSG00000198589
  • Gene Symbol: ATP2B2 (ENSG00000157087)
    Fold Change: 2.54
    Ensembl ID: ENSG00000157087
  • Gene Symbol: DDX5 (ENSG00000108654)
    Fold Change: 2.54
    Ensembl ID: ENSG00000108654
  • Gene Symbol: CKB (ENSG00000166165)
    Fold Change: 2.53
    Ensembl ID: ENSG00000166165
  • Gene Symbol: BBS2 (ENSG00000125124)
    Fold Change: 2.53
    Ensembl ID: ENSG00000125124
  • Gene Symbol: DMD (ENSG00000198947)
    Fold Change: 2.53
    Ensembl ID: ENSG00000198947
  • Gene Symbol: CREBBP (ENSG00000005339)
    Fold Change: 2.52
    Ensembl ID: ENSG00000005339
  • Gene Symbol: ATP1B2 (ENSG00000129244)
    Fold Change: 2.51
    Ensembl ID: ENSG00000129244
  • Gene Symbol: CHN1 (ENSG00000128656)
    Fold Change: 2.51
    Ensembl ID: ENSG00000128656
  • Gene Symbol: FGF2 (ENSG00000138685)
    Fold Change: 2.49
    Ensembl ID: ENSG00000138685

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in astrocyte of the cerebral cortex cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.

Gene ID: A unique numerical identifier for this specific gene.
Symbol: Shortened abbreviation or name that represents this gene.
Ensembl Gene ID: A unique identifier assigned by Ensembl for genomic data mapping.
Fold Change: Indicates the ratio of the gene's expression level in astrocyte of the cerebral cortex cell compared to a baseline. A fold change greater than 1 suggests significant gene expression.
**Key Characteristics** 1. **Location**: The astrocyte is found in the cerebral cortex. 2. **Transcriptomic profile**: The astrocyte has a distinct transcriptomic profile, characterized by the presence of specific genes involved in cell-cell adhesion, signal transduction, and synaptic organization. 3. **Gene expression**: The genes expressed by this astrocyte are CTNND2, DTNA, GPM6A, CTNNA2, ADGRB3, and ERBB4. 4. **Pathways involved**: The astrocyte is involved in various cellular processes, including the Wnt signaling pathway, cadherin binding, and the regulation of canonical Wnt signaling pathway. 5. **Function**: The astrocyte plays a role in the regulation of neuronal cell body, neuron migration, and synapse organization. **Clinical Significance** 1. **Neurological disorders**: The astrocyte's involvement in synaptic organization and neuronal cell body regulation may be relevant to neurological disorders such as Alzheimer's disease, Parkinson's disease, and stroke. 2. **Neurodevelopmental disorders**: The astrocyte's role in neuron migration and synapse organization may be relevant to neurodevelopmental disorders such as autism spectrum disorder and schizophrenia. 3. **Cognitive function**: The astrocyte's involvement in synaptic organization and neuronal cell body regulation may be relevant to cognitive function and may be a potential target for therapeutic interventions aimed at improving cognitive function. 4. **Neuroplasticity**: The astrocyte's role in regulating synaptic organization and neuronal cell body may be relevant to neuroplasticity and may be a potential target for therapeutic interventions aimed at promoting neuroplasticity. In conclusion, the transcriptomically distinct astrocyte found in the cerebral cortex has a unique gene expression profile and is involved in various cellular processes, including cell-cell adhesion, signal transduction, and synaptic organization. Its clinical significance lies in its potential role in neurological disorders, neurodevelopmental disorders, cognitive function, and neuroplasticity. Further research is needed to fully understand the functions and clinical significance of this astrocyte.