Details for: GABRB2
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: Purkinje cell (CL0000121)
Fold Change: 7.1194
Cell Significance Index: 155.8900 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 5.1144
Cell Significance Index: 1834.4400 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 4.9061
Cell Significance Index: 329.8900 - Cell Name: hippocampal interneuron (CL1001569)
Fold Change: 4.2195
Cell Significance Index: 54.7200 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 4.1775
Cell Significance Index: 184.7800 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 4.0639
Cell Significance Index: 153.8900 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 3.8722
Cell Significance Index: 110.5000 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 3.0154
Cell Significance Index: 604.8800 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 2.3184
Cell Significance Index: 142.5000 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 2.0350
Cell Significance Index: 1407.4700 - Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
Fold Change: 1.9198
Cell Significance Index: 25.6100 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 1.3240
Cell Significance Index: 22.6900 - Cell Name: cortical interneuron (CL0008031)
Fold Change: 1.1467
Cell Significance Index: 27.5000 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 1.0658
Cell Significance Index: 202.8400 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.8422
Cell Significance Index: 83.3200 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.5039
Cell Significance Index: 455.0200 - Cell Name: chandelier cell (CL4023083)
Fold Change: 0.4830
Cell Significance Index: 3.9000 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.4571
Cell Significance Index: 28.8100 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.4161
Cell Significance Index: 67.6800 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.3685
Cell Significance Index: 19.3500 - Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
Fold Change: 0.3544
Cell Significance Index: 3.9100 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 0.3217
Cell Significance Index: 33.5000 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.2598
Cell Significance Index: 489.1000 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.1950
Cell Significance Index: 21.2100 - Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 0.0610
Cell Significance Index: 0.5800 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.0497
Cell Significance Index: 2.2600 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0347
Cell Significance Index: 15.7700 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: 0.0264
Cell Significance Index: 0.5300 - Cell Name: glutamatergic neuron (CL0000679)
Fold Change: 0.0174
Cell Significance Index: 0.1900 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 0.0047
Cell Significance Index: 0.1000 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0248
Cell Significance Index: -0.8700 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0263
Cell Significance Index: -48.4800 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.0284
Cell Significance Index: -0.7100 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0309
Cell Significance Index: -47.5400 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0360
Cell Significance Index: -48.9800 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0621
Cell Significance Index: -39.4400 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0648
Cell Significance Index: -47.5200 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0716
Cell Significance Index: -53.0600 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0736
Cell Significance Index: -55.6900 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0890
Cell Significance Index: -55.5700 - Cell Name: cell in vitro (CL0001034)
Fold Change: -0.0913
Cell Significance Index: -49.8400 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0915
Cell Significance Index: -51.6300 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.0978
Cell Significance Index: -1.4000 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.1108
Cell Significance Index: -2.1900 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.1197
Cell Significance Index: -3.4500 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: -0.1202
Cell Significance Index: -1.8600 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1276
Cell Significance Index: -36.7000 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.1318
Cell Significance Index: -7.9100 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.1399
Cell Significance Index: -4.5800 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1529
Cell Significance Index: -22.2200 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.1583
Cell Significance Index: -3.4200 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.1731
Cell Significance Index: -3.5900 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.1787
Cell Significance Index: -5.6900 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.1925
Cell Significance Index: -4.1700 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.1956
Cell Significance Index: -5.4700 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.2050
Cell Significance Index: -36.9600 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.2230
Cell Significance Index: -15.4200 - Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.2269
Cell Significance Index: -45.0400 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.2456
Cell Significance Index: -51.7300 - Cell Name: GABAergic neuron (CL0000617)
Fold Change: -0.2536
Cell Significance Index: -3.2000 - Cell Name: retinal ganglion cell (CL0000740)
Fold Change: -0.2556
Cell Significance Index: -2.1100 - Cell Name: inhibitory interneuron (CL0000498)
Fold Change: -0.2684
Cell Significance Index: -3.2100 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.3014
Cell Significance Index: -51.4700 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.3065
Cell Significance Index: -37.6900 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.3562
Cell Significance Index: -48.9200 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.3778
Cell Significance Index: -48.8100 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.3915
Cell Significance Index: -5.9000 - Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -0.4218
Cell Significance Index: -5.2600 - Cell Name: neural cell (CL0002319)
Fold Change: -0.4252
Cell Significance Index: -4.9600 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.4344
Cell Significance Index: -50.6200 - Cell Name: pyramidal neuron (CL0000598)
Fold Change: -0.4407
Cell Significance Index: -3.3800 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.4419
Cell Significance Index: -50.6300 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.4425
Cell Significance Index: -52.1800 - Cell Name: neuron (CL0000540)
Fold Change: -0.4473
Cell Significance Index: -4.2400 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.4532
Cell Significance Index: -58.1000 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.4582
Cell Significance Index: -11.4300 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.5179
Cell Significance Index: -52.9000 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -0.5318
Cell Significance Index: -11.1000 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.5412
Cell Significance Index: -33.1800 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.5859
Cell Significance Index: -44.9600 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.6152
Cell Significance Index: -48.7300 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.6376
Cell Significance Index: -20.4200 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.6397
Cell Significance Index: -22.4100 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.6567
Cell Significance Index: -48.9400 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: -0.6808
Cell Significance Index: -13.4000 - Cell Name: ON midget ganglion cell (CL4033046)
Fold Change: -0.7028
Cell Significance Index: -8.8700 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.7127
Cell Significance Index: -15.2400 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.7393
Cell Significance Index: -38.5100 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.7463
Cell Significance Index: -41.8800 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.8449
Cell Significance Index: -18.0000 - Cell Name: myeloid dendritic cell (CL0000782)
Fold Change: -0.8964
Cell Significance Index: -7.0300 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.9267
Cell Significance Index: -48.1400 - Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
Fold Change: -0.9368
Cell Significance Index: -18.6800 - Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
Fold Change: -0.9415
Cell Significance Index: -12.5500 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: -0.9534
Cell Significance Index: -6.4600 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: -0.9631
Cell Significance Index: -11.9500 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -1.0219
Cell Significance Index: -48.0300 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -1.0576
Cell Significance Index: -49.3100 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: -1.2062
Cell Significance Index: -12.1500 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -1.2411
Cell Significance Index: -45.5600
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 15910844
Symbol: GBRB2_HUMAN
Name: GABA(A) receptor subunit beta-2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8264558
Title: Role of the beta subunit in determining the pharmacology of human gamma-aminobutyric acid type A receptors.
PubMed ID: 8264558
PubMed ID: 7707873
Title: Cloning, sequence analysis and expression of two forms of mRNA coding for the human beta 2 subunit of the GABAA receptor.
PubMed ID: 7707873
PubMed ID: 19763268
Title: Alternative-splicing in the exon-10 region of GABA(A) receptor beta(2) subunit gene: relationships between novel isoforms and psychotic disorders.
PubMed ID: 19763268
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 16983389
Title: Two isoforms of GABA(A) receptor beta2 subunit with different electrophysiological properties: Differential expression and genotypical correlations in schizophrenia.
PubMed ID: 16983389
PubMed ID: 23909897
Title: GABA(A) receptors can initiate the formation of functional inhibitory GABAergic synapses.
PubMed ID: 23909897
DOI: 10.1111/ejn.12331
PubMed ID: 25489750
Title: Inhibitory synapse formation in a co-culture model incorporating GABAergic medium spiny neurons and HEK293 cells stably expressing GABAA receptors.
PubMed ID: 25489750
DOI: 10.3791/52115
PubMed ID: 29950725
Title: Structure of a human synaptic GABAA receptor.
PubMed ID: 29950725
PubMed ID: 25124326
Title: A novel variant in GABRB2 associated with intellectual disability and epilepsy.
PubMed ID: 25124326
DOI: 10.1002/ajmg.a.36714
PubMed ID: 29100083
Title: High rate of recurrent de novo mutations in developmental and epileptic encephalopathies.
PubMed ID: 29100083
PubMed ID: 27789573
Title: A de novo missense mutation of GABRB2 causes early myoclonic encephalopathy.
PubMed ID: 27789573
Sequence Information:
- Length: 512
- Mass: 59150
- Checksum: C390A0C92815DD89
- Sequence:
MWRVRKRGYF GIWSFPLIIA AVCAQSVNDP SNMSLVKETV DRLLKGYDIR LRPDFGGPPV AVGMNIDIAS IDMVSEVNMD YTLTMYFQQA WRDKRLSYNV IPLNLTLDNR VADQLWVPDT YFLNDKKSFV HGVTVKNRMI RLHPDGTVLY GLRITTTAAC MMDLRRYPLD EQNCTLEIES YGYTTDDIEF YWRGDDNAVT GVTKIELPQF SIVDYKLITK KVVFSTGSYP RLSLSFKLKR NIGYFILQTY MPSILITILS WVSFWINYDA SAARVALGIT TVLTMTTINT HLRETLPKIP YVKAIDMYLM GCFVFVFMAL LEYALVNYIF FGRGPQRQKK AAEKAASANN EKMRLDVNKI FYKDIKQNGT QYRSLWDPTG NLSPTRRTTN YDFSLYTMDP HENILLSTLE IKNEMATSEA VMGLGDPRST MLAYDASSIQ YRKAGLPRHS FGRNALERHV AQKKSRLRRR ASQLKITIPD LTDVNAIDRW SRIFFPVVFS FFNIVYWLYY VN
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.