Details for: GABRB2
Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: Purkinje cell (CL0000121)
Fold Change: 4.8
Marker Score: 162,066 - Cell Name: macroglial cell (CL0000126)
Fold Change: 4.18
Marker Score: 9,617 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 2.84
Marker Score: 21,758 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 2.84
Marker Score: 42,407 - Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 2.68
Marker Score: 101,876 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 2.6
Marker Score: 10,772 - Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 2.56
Marker Score: 7,291 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 2.52
Marker Score: 50,142 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 2.44
Marker Score: 90,152 - Cell Name: pyramidal neuron (CL0000598)
Fold Change: 2.39
Marker Score: 4,014 - Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 2.36
Marker Score: 9,106 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 2.18
Marker Score: 20,529 - Cell Name: granule cell (CL0000120)
Fold Change: 2.16
Marker Score: 16,268 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.07
Marker Score: 127,571 - Cell Name: GABAergic neuron (CL0000617)
Fold Change: 2.07
Marker Score: 8,641 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 2.03
Marker Score: 641 - Cell Name: neuron (CL0000540)
Fold Change: 1.95
Marker Score: 7,938 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.93
Marker Score: 18,307 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.88
Marker Score: 16,111 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.65
Marker Score: 2,548 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.65
Marker Score: 3,126 - Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 1.62
Marker Score: 680 - Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 1.6
Marker Score: 7,399 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 1.51
Marker Score: 6,304 - Cell Name: mural cell (CL0008034)
Fold Change: 1.47
Marker Score: 168,452 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.39
Marker Score: 14,333 - Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.37
Marker Score: 868 - Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 1.31
Marker Score: 358 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.27
Marker Score: 2,584 - Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 1.12
Marker Score: 1,293 - Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 1.1
Marker Score: 2,585 - Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 1.08
Marker Score: 1,341 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 1.05
Marker Score: 2,299 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: 1.04
Marker Score: 795 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.04
Marker Score: 251,788 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 1.01
Marker Score: 607 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71,808 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48,034 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.98
Marker Score: 507 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,408 - Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.98
Marker Score: 461 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2,413 - Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.93
Marker Score: 5,335 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.93
Marker Score: 373 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.92
Marker Score: 2,742 - Cell Name: germ cell (CL0000586)
Fold Change: 0.91
Marker Score: 1,595 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9
Marker Score: 325 - Cell Name: neuronal brush cell (CL0000555)
Fold Change: 0.89
Marker Score: 2,982 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5,287 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.86
Marker Score: 3,612 - Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 0.83
Marker Score: 785 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.83
Marker Score: 999 - Cell Name: ganglion interneuron (CL0000397)
Fold Change: 0.81
Marker Score: 247 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 0.79
Marker Score: 16,938 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1,261 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.77
Marker Score: 462 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.77
Marker Score: 12,014 - Cell Name: pulmonary ionocyte (CL0017000)
Fold Change: 0.76
Marker Score: 470 - Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 395 - Cell Name: precursor B cell (CL0000817)
Fold Change: 0.75
Marker Score: 499 - Cell Name: brush cell (CL0002204)
Fold Change: 0.74
Marker Score: 671 - Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 0.7
Marker Score: 860 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.69
Marker Score: 178 - Cell Name: respiratory basal cell (CL0002633)
Fold Change: 0.69
Marker Score: 987 - Cell Name: oogonial cell (CL0000024)
Fold Change: 0.68
Marker Score: 971 - Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 0.65
Marker Score: 2,408 - Cell Name: stellate neuron (CL0000122)
Fold Change: 0.65
Marker Score: 3,471 - Cell Name: interneuron (CL0000099)
Fold Change: 0.63
Marker Score: 288 - Cell Name: glutamatergic neuron (CL0000679)
Fold Change: 0.63
Marker Score: 6,384 - Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.62
Marker Score: 279 - Cell Name: mature microglial cell (CL0002629)
Fold Change: 0.6
Marker Score: 218 - Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.6
Marker Score: 192 - Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.59
Marker Score: 283 - Cell Name: mature astrocyte (CL0002627)
Fold Change: 0.59
Marker Score: 388 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.57
Marker Score: 362 - Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 444 - Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.55
Marker Score: 231 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.55
Marker Score: 1,119 - Cell Name: cerebellar granule cell precursor (CL0002362)
Fold Change: 0.55
Marker Score: 307 - Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 0.5
Marker Score: 161 - Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.49
Marker Score: 127 - Cell Name: starburst amacrine cell (CL0004232)
Fold Change: 0.46
Marker Score: 130 - Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.45
Marker Score: 141 - Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.44
Marker Score: 117 - Cell Name: transitional stage B cell (CL0000818)
Fold Change: 0.44
Marker Score: 156 - Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 0.43
Marker Score: 1,532 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.43
Marker Score: 165 - Cell Name: CNS interneuron (CL0000402)
Fold Change: 0.41
Marker Score: 196 - Cell Name: pro-B cell (CL0000826)
Fold Change: 0.4
Marker Score: 390 - Cell Name: microglial cell (CL0000129)
Fold Change: 0.4
Marker Score: 734 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.39
Marker Score: 282 - Cell Name: rod bipolar cell (CL0000751)
Fold Change: 0.39
Marker Score: 202 - Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 0.37
Marker Score: 180 - Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.37
Marker Score: 371 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.37
Marker Score: 181 - Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
Fold Change: 0.36
Marker Score: 109 - Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
Fold Change: 0.36
Marker Score: 1,900 - Cell Name: ependymal cell (CL0000065)
Fold Change: 0.36
Marker Score: 126 - Cell Name: mast cell (CL0000097)
Fold Change: 0.35
Marker Score: 205 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.35
Marker Score: 238
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 15910844
Symbol: GBRB2_HUMAN
Name: Gamma-aminobutyric acid receptor subunit beta-2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8264558
Title: Role of the beta subunit in determining the pharmacology of human gamma-aminobutyric acid type A receptors.
PubMed ID: 8264558
PubMed ID: 7707873
Title: Cloning, sequence analysis and expression of two forms of mRNA coding for the human beta 2 subunit of the GABAA receptor.
PubMed ID: 7707873
PubMed ID: 19763268
Title: Alternative-splicing in the exon-10 region of GABA(A) receptor beta(2) subunit gene: relationships between novel isoforms and psychotic disorders.
PubMed ID: 19763268
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 16983389
Title: Two isoforms of GABA(A) receptor beta2 subunit with different electrophysiological properties: Differential expression and genotypical correlations in schizophrenia.
PubMed ID: 16983389
PubMed ID: 23909897
Title: GABA(A) receptors can initiate the formation of functional inhibitory GABAergic synapses.
PubMed ID: 23909897
DOI: 10.1111/ejn.12331
PubMed ID: 25489750
Title: Inhibitory synapse formation in a co-culture model incorporating GABAergic medium spiny neurons and HEK293 cells stably expressing GABAA receptors.
PubMed ID: 25489750
DOI: 10.3791/52115
PubMed ID: 29950725
Title: Structure of a human synaptic GABAA receptor.
PubMed ID: 29950725
PubMed ID: 25124326
Title: A novel variant in GABRB2 associated with intellectual disability and epilepsy.
PubMed ID: 25124326
DOI: 10.1002/ajmg.a.36714
PubMed ID: 29100083
Title: High rate of recurrent de novo mutations in developmental and epileptic encephalopathies.
PubMed ID: 29100083
PubMed ID: 27789573
Title: A de novo missense mutation of GABRB2 causes early myoclonic encephalopathy.
PubMed ID: 27789573
Sequence Information:
- Length: 512
- Mass: 59150
- Checksum: C390A0C92815DD89
- Sequence:
MWRVRKRGYF GIWSFPLIIA AVCAQSVNDP SNMSLVKETV DRLLKGYDIR LRPDFGGPPV AVGMNIDIAS IDMVSEVNMD YTLTMYFQQA WRDKRLSYNV IPLNLTLDNR VADQLWVPDT YFLNDKKSFV HGVTVKNRMI RLHPDGTVLY GLRITTTAAC MMDLRRYPLD EQNCTLEIES YGYTTDDIEF YWRGDDNAVT GVTKIELPQF SIVDYKLITK KVVFSTGSYP RLSLSFKLKR NIGYFILQTY MPSILITILS WVSFWINYDA SAARVALGIT TVLTMTTINT HLRETLPKIP YVKAIDMYLM GCFVFVFMAL LEYALVNYIF FGRGPQRQKK AAEKAASANN EKMRLDVNKI FYKDIKQNGT QYRSLWDPTG NLSPTRRTTN YDFSLYTMDP HENILLSTLE IKNEMATSEA VMGLGDPRST MLAYDASSIQ YRKAGLPRHS FGRNALERHV AQKKSRLRRR ASQLKITIPD LTDVNAIDRW SRIFFPVVFS FFNIVYWLYY VN
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.