Details for: ZNF154

Gene ID: 7710

Symbol: ZNF154

Ensembl ID: ENSG00000179909

Description: zinc finger protein 154

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 43.2029
    Cell Significance Index: -6.7200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 24.8380
    Cell Significance Index: -6.3000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 17.3444
    Cell Significance Index: -7.1500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 14.6213
    Cell Significance Index: -5.9400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 6.2635
    Cell Significance Index: -5.9800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 5.5639
    Cell Significance Index: -6.8600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.5645
    Cell Significance Index: -6.8700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.8660
    Cell Significance Index: 59.7700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.7663
    Cell Significance Index: -6.9700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.4901
    Cell Significance Index: 30.8900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.3978
    Cell Significance Index: 8.7100
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.3826
    Cell Significance Index: 5.3700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3750
    Cell Significance Index: 71.3600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.3738
    Cell Significance Index: 5.1000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3370
    Cell Significance Index: 67.6000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3123
    Cell Significance Index: 8.3700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2272
    Cell Significance Index: 81.4800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2132
    Cell Significance Index: 4.5400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2044
    Cell Significance Index: 9.0400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.2043
    Cell Significance Index: 7.7400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2023
    Cell Significance Index: 10.5100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2011
    Cell Significance Index: 12.0700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1944
    Cell Significance Index: 11.9500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1907
    Cell Significance Index: 10.7000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.1860
    Cell Significance Index: 4.4600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1783
    Cell Significance Index: 13.6900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1696
    Cell Significance Index: 16.7800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1511
    Cell Significance Index: 29.9900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1433
    Cell Significance Index: 15.5900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1308
    Cell Significance Index: 118.1000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1071
    Cell Significance Index: 5.5800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1036
    Cell Significance Index: 18.6800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0995
    Cell Significance Index: 16.1900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0781
    Cell Significance Index: 2.2500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.0770
    Cell Significance Index: 0.9500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0562
    Cell Significance Index: 3.8900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0418
    Cell Significance Index: 5.1400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0418
    Cell Significance Index: 0.7000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0410
    Cell Significance Index: 0.8500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0356
    Cell Significance Index: 2.4000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0283
    Cell Significance Index: 53.2900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0248
    Cell Significance Index: 15.7800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0246
    Cell Significance Index: 1.5900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0213
    Cell Significance Index: 9.6800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0210
    Cell Significance Index: 2.4500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0154
    Cell Significance Index: 0.5400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0126
    Cell Significance Index: 5.5500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0053
    Cell Significance Index: 2.8700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0046
    Cell Significance Index: 0.5400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0045
    Cell Significance Index: 6.8600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0037
    Cell Significance Index: 6.7800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0016
    Cell Significance Index: 2.1800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0008
    Cell Significance Index: 0.0200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0014
    Cell Significance Index: -0.2000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0014
    Cell Significance Index: -0.0200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0038
    Cell Significance Index: -2.7600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0044
    Cell Significance Index: -3.2600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0057
    Cell Significance Index: -0.0700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0066
    Cell Significance Index: -0.3000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0082
    Cell Significance Index: -6.1900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0083
    Cell Significance Index: -0.1800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0088
    Cell Significance Index: -2.5400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0088
    Cell Significance Index: -0.1500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0092
    Cell Significance Index: -5.1700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0104
    Cell Significance Index: -1.3300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0200
    Cell Significance Index: -2.7400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0254
    Cell Significance Index: -0.7100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0265
    Cell Significance Index: -0.4000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0290
    Cell Significance Index: -3.3200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0309
    Cell Significance Index: -6.5000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0318
    Cell Significance Index: -3.3100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0319
    Cell Significance Index: -1.4900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0320
    Cell Significance Index: -5.4700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0372
    Cell Significance Index: -3.8100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0396
    Cell Significance Index: -5.1200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0430
    Cell Significance Index: -0.9000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0445
    Cell Significance Index: -3.3200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0520
    Cell Significance Index: -1.4900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0528
    Cell Significance Index: -3.2400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0528
    Cell Significance Index: -1.2200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0570
    Cell Significance Index: -1.2100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0583
    Cell Significance Index: -1.4900
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0672
    Cell Significance Index: -0.8600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0707
    Cell Significance Index: -5.0000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0763
    Cell Significance Index: -2.6500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0770
    Cell Significance Index: -6.1000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0773
    Cell Significance Index: -2.5300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0791
    Cell Significance Index: -2.0800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0792
    Cell Significance Index: -4.1600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0830
    Cell Significance Index: -2.0700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0838
    Cell Significance Index: -2.6700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0858
    Cell Significance Index: -2.3400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0860
    Cell Significance Index: -1.7000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0860
    Cell Significance Index: -4.0400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0866
    Cell Significance Index: -1.8700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1006
    Cell Significance Index: -1.4400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1042
    Cell Significance Index: -0.9600
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.1123
    Cell Significance Index: -1.6800
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.1126
    Cell Significance Index: -1.6200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1166
    Cell Significance Index: -3.1200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcriptional Regulation:** ZNF154 is a transcription factor that binds to specific DNA sequences, regulating the expression of target genes. Its ability to bind to RNA polymerase II-specific sequences suggests a role in transcriptional activation or repression. 2. **Metal Ion Binding:** The presence of a metal ion binding domain in ZNF154 suggests that it may interact with metal ions, potentially influencing its DNA binding properties or other cellular processes. 3. **Cell Type-Specific Expression:** ZNF154 is expressed in various cell types, including goblet cells, enterocytes, and stem cells, highlighting its importance in maintaining tissue homeostasis and development. 4. **Conservation across Species:** The conservation of ZNF154 across species, including humans, suggests that it plays a conserved role in regulating gene expression and cellular differentiation. **Pathways and Functions:** 1. **DNA-Binding Transcription Factor Activity:** ZNF154's ability to bind to specific DNA sequences suggests a role in transcriptional regulation. 2. **RNA Polymerase II-Dependent Gene Expression:** ZNF154's interaction with RNA polymerase II-specific sequences suggests a role in regulating gene expression through this pathway. 3. **Metal Ion Binding and Transcriptional Regulation:** The metal ion binding domain in ZNF154 may influence its DNA binding properties or other cellular processes. 4. **Cellular Differentiation and Homeostasis:** ZNF154's expression in various cell types and its role in regulating gene expression suggest its importance in maintaining tissue homeostasis and development. **Clinical Significance:** 1. **Cancer Research:** ZNF154's role in regulating gene expression and cellular differentiation makes it a potential target for cancer research. Alterations in ZNF154 expression or function may contribute to tumorigenesis or cancer progression. 2. **Neurological Disorders:** ZNF154's expression in the brain and its role in regulating gene expression suggest its potential involvement in neurological disorders, such as autism or schizophrenia. 3. **Intestinal Disorders:** ZNF154's expression in the intestinal epithelium and its role in regulating gene expression make it a potential target for research into intestinal disorders, such as inflammatory bowel disease. In conclusion, ZNF154 is a transcriptional regulator that plays a crucial role in maintaining tissue homeostasis and development. Its involvement in regulating gene expression, metal ion binding, and RNA polymerase II-dependent gene expression makes it a promising target for research into various diseases, including cancer, neurological disorders, and intestinal disorders. Further studies are necessary to fully elucidate the molecular mechanisms underlying ZNF154's functions and to explore its potential therapeutic applications.

Genular Protein ID: 910277120

Symbol: ZN154_HUMAN

Name: Zinc finger protein 154

UniProtKB Accession Codes:

Q13106 A7MCY3 Q8IVG7 Q8NAR0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 3 ExpressionAtlas 1 GO 5 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7557990

Title: Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders.

PubMed ID: 7557990

DOI: 10.1006/geno.1995.1040

Sequence Information:

  • Length: 437
  • Mass: 49865
  • Checksum: 37469112DC85BFEB
  • Sequence:
    • MAAATLRTPT QGTVTFEDVA VHFSWEEWGL LDEAQRCLYR DVMLENLALL TSLDVHHQKQ 
HLGEKHFRSN VGRALFVKTC TFHVSGEPST CREVGKDFLA KLGFLHQQAA HTGEQSNSKS 
DGGAISHRGK THYNCGEHTK AFSGKHTLVQ QQRTLTTERC YICSECGKSF SKSYSLNDHW 
RLHTGEKPYE CRECGKSFRQ SSSLIQHRRV HTAVRPHECD ECGKLFSNKS NLIKHRRVHT 
GERPYECSEC GKSFSQRSAL LQHRGVHTGE RPYECSECGK FFTYHSSLIK HQKVHSGSRP 
YECSECGKSF SQNSSLIEHH RVHTGERPYK CSECGKSFSQ RSALLQHRGV HTGERPYECS 
ECGKFFPYSS SLRKHQRVHT GSRPYECSEC GKSFTQNSGL IKHRRVHTGE KPYECTECGK 
SFSHNSSLIK HQRIHSR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.