Details for: OAZ1

Gene ID: 4946

Symbol: OAZ1

Ensembl ID: ENSG00000104904

Description: ornithine decarboxylase antizyme 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 801.1175
    Cell Significance Index: -124.6100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 510.0468
    Cell Significance Index: -129.3700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 430.8072
    Cell Significance Index: -177.4700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 407.1313
    Cell Significance Index: -165.4000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 364.3333
    Cell Significance Index: -172.0100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 351.9347
    Cell Significance Index: -181.0300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 257.3238
    Cell Significance Index: -172.6700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 176.0579
    Cell Significance Index: -168.0900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 113.8159
    Cell Significance Index: -140.3300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 50.3475
    Cell Significance Index: -154.6400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 44.0947
    Cell Significance Index: -174.0000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 14.3424
    Cell Significance Index: 265.0900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 14.2719
    Cell Significance Index: -38.2300
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 10.4670
    Cell Significance Index: 28.0400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 7.3850
    Cell Significance Index: 347.0900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 7.1292
    Cell Significance Index: 374.3100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 6.2533
    Cell Significance Index: 737.4600
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 4.9470
    Cell Significance Index: 30.4500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 4.8731
    Cell Significance Index: 363.1900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 4.7853
    Cell Significance Index: 223.1200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 4.2350
    Cell Significance Index: 581.5900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 4.1592
    Cell Significance Index: 122.1500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 4.1255
    Cell Significance Index: 108.4800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 4.1112
    Cell Significance Index: 505.5100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 4.0622
    Cell Significance Index: 262.0800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 3.9321
    Cell Significance Index: 708.8300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.7944
    Cell Significance Index: 108.7700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.6353
    Cell Significance Index: 1985.3300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 3.2684
    Cell Significance Index: 37.1300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 3.1742
    Cell Significance Index: 410.0800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.0515
    Cell Significance Index: 83.0600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 2.9914
    Cell Significance Index: 1322.5500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 2.5364
    Cell Significance Index: 325.1500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.1713
    Cell Significance Index: 20.0000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.9941
    Cell Significance Index: 141.0300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.9684
    Cell Significance Index: 194.7200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.7016
    Cell Significance Index: 59.1300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.6963
    Cell Significance Index: 29.9800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.3742
    Cell Significance Index: 275.6600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 1.2507
    Cell Significance Index: 946.6700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.2314
    Cell Significance Index: 28.4500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.1695
    Cell Significance Index: 199.7000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8101
    Cell Significance Index: 42.0800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4931
    Cell Significance Index: 93.8400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4091
    Cell Significance Index: 146.7300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2281
    Cell Significance Index: 6.0900
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.1990
    Cell Significance Index: 1.7100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.1341
    Cell Significance Index: 98.3400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1148
    Cell Significance Index: 5.9800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0493
    Cell Significance Index: 0.8300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0030
    Cell Significance Index: -0.1100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0041
    Cell Significance Index: -0.4200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0146
    Cell Significance Index: -0.7400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0625
    Cell Significance Index: -46.2600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0828
    Cell Significance Index: -155.8800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0930
    Cell Significance Index: -58.0800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.1192
    Cell Significance Index: -219.8400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.1436
    Cell Significance Index: -221.0600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.1662
    Cell Significance Index: -225.9500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1822
    Cell Significance Index: -8.2600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.2221
    Cell Significance Index: -125.2600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.2470
    Cell Significance Index: -170.8600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.2577
    Cell Significance Index: -163.6600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3375
    Cell Significance Index: -13.8300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3651
    Cell Significance Index: -76.9000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.3941
    Cell Significance Index: -178.8600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4087
    Cell Significance Index: -8.5600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4314
    Cell Significance Index: -27.1900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.5226
    Cell Significance Index: -150.3600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.7576
    Cell Significance Index: -86.4800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.8613
    Cell Significance Index: -170.9300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.8767
    Cell Significance Index: -100.4400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.9903
    Cell Significance Index: -25.3000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -1.0478
    Cell Significance Index: -122.1100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.1321
    Cell Significance Index: -89.6600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -1.1762
    Cell Significance Index: -170.9800
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -1.1767
    Cell Significance Index: -9.0700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -1.2225
    Cell Significance Index: -75.1400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.6345
    Cell Significance Index: -52.3500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.6856
    Cell Significance Index: -175.5100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.6973
    Cell Significance Index: -45.4800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -1.8893
    Cell Significance Index: -28.3100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.9355
    Cell Significance Index: -148.5300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.9372
    Cell Significance Index: -41.9700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.9595
    Cell Significance Index: -33.7800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -2.0235
    Cell Significance Index: -56.5500
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -2.1081
    Cell Significance Index: -15.1400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -2.4284
    Cell Significance Index: -64.9600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -2.5396
    Cell Significance Index: -142.5100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -2.6317
    Cell Significance Index: -176.9600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -2.6434
    Cell Significance Index: -56.3000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -2.7003
    Cell Significance Index: -79.5400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -2.8147
    Cell Significance Index: -172.5700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -2.8844
    Cell Significance Index: -36.9400
  • Cell Name: theca cell (CL0000503)
    Fold Change: -3.0281
    Cell Significance Index: -17.7900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -3.0603
    Cell Significance Index: -18.4900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -3.1298
    Cell Significance Index: -138.4400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -3.2997
    Cell Significance Index: -95.0700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -3.3015
    Cell Significance Index: -26.3600
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -3.3080
    Cell Significance Index: -46.4000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Inhibitory activity on ODC**: OAZ1 is a potent inhibitor of ornithine decarboxylase (ODC), an enzyme involved in the biosynthesis of polyamines, which are essential for cell growth and proliferation. 2. **Regulation of polyamine biosynthesis**: By inhibiting ODC, OAZ1 regulates the biosynthesis of polyamines, which are critical for various cellular processes, including cell growth, differentiation, and survival. 3. **Positive regulation of protein catabolic processes**: OAZ1 also promotes protein degradation, which is essential for maintaining protein homeostasis and regulating cellular processes. 4. **Expression in various cell types**: OAZ1 is expressed in multiple cell types, including myoepithelial cells of the mammary gland, mature T cells, malignant cells, and immune cells such as macrophages and natural killer cells. **Pathways and Functions:** 1. **Polyamine biosynthesis**: OAZ1 inhibits ODC, thereby regulating the biosynthesis of polyamines. This process is essential for cell growth, differentiation, and survival. 2. **Protein catabolic processes**: OAZ1 promotes protein degradation, which is critical for maintaining protein homeostasis and regulating cellular processes. 3. **Immune regulation**: OAZ1 is expressed in immune cells, where it regulates immune responses, including the activation of macrophages and natural killer cells. 4. **Cell growth and proliferation**: OAZ1 regulates cell growth and proliferation by controlling polyamine biosynthesis and protein catabolism. **Clinical Significance:** 1. **Cancer therapy**: OAZ1's role in regulating polyamine biosynthesis and protein catabolism makes it a potential target for cancer therapy. Inhibiting OAZ1 could lead to the development of novel anticancer agents. 2. **Immune disorders**: OAZ1's expression in immune cells suggests that it may be involved in the regulation of immune responses. Dysregulation of OAZ1 could contribute to immune disorders, such as autoimmune diseases. 3. **Aging and age-related diseases**: OAZ1's role in regulating protein catabolism and polyamine biosynthesis makes it a potential target for the development of novel therapies for age-related diseases, such as Alzheimer's disease and cancer. 4. **Pharmacological applications**: OAZ1's dual functions as an inhibitor of ODC and a positive regulator of protein catabolic processes make it a potential target for the development of novel pharmaceuticals, including anticancer agents and immunomodulators. In conclusion, OAZ1 is a multifunctional protein that plays a critical role in regulating polyamine biosynthesis and protein catabolism. Its expression in various cell types, including immune cells, suggests that it may be involved in the regulation of immune responses. Further research on OAZ1's role in polyamine metabolism and immune regulation has significant implications for the development of novel therapeutic strategies for diseases characterized by altered polyamine levels and immune dysregulation.

Genular Protein ID: 3123809314

Symbol: OAZ1_HUMAN

Name: Ornithine decarboxylase antizyme 1

UniProtKB Accession Codes:

P54368 O43382 Q14989 Q92595 Q9UPL9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 1 EMBL 9 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7811704

Title: Molecular cloning and sequencing of a human cDNA encoding ornithine decarboxylase antizyme.

PubMed ID: 7811704

DOI: 10.1016/0167-4838(94)90199-6

PubMed ID: 9132164

Title: Molecular cloning of human antizyme cDNA.

PubMed ID: 9132164

PubMed ID: 9426243

Title: Characterization of the human antizyme gene.

PubMed ID: 9426243

DOI: 10.1016/s0378-1119(97)00504-0

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 12097147

Title: A novel link between the proteasome pathway and the signal transduction pathway of the bone morphogenetic proteins (BMPs).

PubMed ID: 12097147

DOI: 10.1186/1471-2121-3-15

PubMed ID: 17900240

Title: Human ornithine decarboxylase paralogue (ODCp) is an antizyme inhibitor but not an arginine decarboxylase.

PubMed ID: 17900240

DOI: 10.1042/bj20071004

PubMed ID: 30312582

Title: Astroprincin (FAM171A1, C10orf38): A Regulator of Human Cell Shape and Invasive Growth.

PubMed ID: 30312582

DOI: 10.1016/j.ajpath.2018.09.006

PubMed ID: 26305948

Title: Structural basis of antizyme-mediated regulation of polyamine homeostasis.

PubMed ID: 26305948

DOI: 10.1073/pnas.1508187112

PubMed ID: 26443277

Title: Structural basis of ornithine decarboxylase inactivation and accelerated degradation by polyamine sensor antizyme1.

PubMed ID: 26443277

DOI: 10.1038/srep14738

Sequence Information:

  • Length: 228
  • Mass: 25406
  • Checksum: DA43B74DF030BD9D
  • Sequence:
    • MVKSSLQRIL NSHCFAREKE GDKPSATIHA SRTMPLLSLH SRGGSSSESS RVSLHCCSNP 
GPGPRWCSDA PHPPLKIPGG RGNSQRDHNL SANLFYSDDR LNVTEELTSN DKTRILNVQS 
RLTDAKRINW RTVLSGGSLY IEIPGGALPE GSKDSFAVLL EFAEEQLRAD HVFICFHKNR 
EDRAALLRTF SFLGFEIVRP GHPLVPKRPD ACFMAYTFER ESSGEEEE

Genular Protein ID: 1723591950

Symbol: J3QQY4_HUMAN

Name: N/A

UniProtKB Accession Codes:

J3QQY4

Database IDs:

ARBA 4 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 1 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 3 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 226
  • Mass: 25231
  • Checksum: CB775E0209975BD6
  • Sequence:
    • MVKSSLQRIL NSHCFAREKE GDKPSATIHA SRTMPLLSLH SRGGSSSERV SLHCCSNPGP 
GPRWCSDAPH PPLKIPGGRG NSQRDHNLSA NLFYSDDRLN VTEELTSNDK TRILNVQSRL 
TDAKRINWRT VLSGGSLYIE IPGGALPEGS KDSFAVLLEF AEEQLRADHV FICFHKNRED 
RAALLRTFSF LGFEIVRPGH PLVPKRPDAC FMAYTFERES SGEEEE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.