Details for: GRM5
Gene ID: 2915
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: GRM5
Ensembl ID: ENSG00000168959
Description: glutamate metabotropic receptor 5
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 79.12rCSI 98.43%PRS 99.5
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CSI 67.85rCSI 87.47%PRS 99.69
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CSI 65.62rCSI 78.38%PRS 99.53
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CSI 61.81rCSI 84.58%PRS 99.61
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CSI 55.83rCSI 93.72%PRS 99.57
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CSI 51.68rCSI 100%PRS 99.28
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CSI 51.22rCSI 95.93%PRS 99.5
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CSI 50.91rCSI 81.87%PRS 99.4
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CSI 49.74rCSI 90.38%PRS 99.78
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CSI 48.95rCSI 86.45%PRS 99.49
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CSI 48.93rCSI 100%PRS 99.69
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CSI 45.35rCSI 98.38%PRS 99.62
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CSI 38.81rCSI 100%PRS 99.36
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CSI 38.07rCSI 91.04%PRS 99.59
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CSI 36.45rCSI 88.58%PRS 99.21
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CSI 31.27rCSI 64.26%PRS 98.65
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CSI 29.41rCSI 91.92%PRS 99.5
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CSI 28.62rCSI 51.42%PRS 99.68
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CSI 28.07rCSI 87.78%PRS 99.61
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CSI 28.04rCSI 56.31%PRS 99.8
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CSI 26.47rCSI 87.01%PRS 99.5
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CSI 25.02rCSI 100%PRS 99.7
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CSI 24.99rCSI 94.31%PRS 99.33
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CSI 24.83rCSI 89.37%PRS 99.33
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CSI 24.44rCSI 63.66%PRS 99.64
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CSI 24.14rCSI 100%PRS 99.14
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CSI 23.92rCSI 90.39%PRS 99.3
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CSI 23.17rCSI 34.06%PRS 99.74
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CSI 22.73rCSI 76.14%PRS 98.54
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CSI 21.04rCSI 100%PRS 99.41
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CSI 19.87rCSI 68.06%PRS 99.45
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CSI 19.16rCSI 28.48%PRS 99.75
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CSI 18.82rCSI 21.77%PRS 99.62
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CSI 17.84rCSI 93.81%PRS 99.6
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CSI 17.21rCSI 49.87%PRS 99.66
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CSI 16.56rCSI 63.06%PRS 99.4
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CSI 15.05rCSI 88.6%PRS 99.42
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CSI 13.93rCSI 82.24%PRS 99.47
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CSI 12.13rCSI 17.2%PRS 99.78
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CSI 12.11rCSI 20.94%PRS 99.75
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CSI 11.32rCSI 29.11%PRS 99.86
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CSI 10.83rCSI 30.79%PRS 99.77
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CSI 10.28rCSI 88.57%PRS 99.69
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CSI 9.47rCSI 16.61%PRS 99.83
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CSI 9.34rCSI 68.67%PRS 99.75
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CSI 8.77rCSI 19.67%PRS 99.51
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CSI 8.36rCSI 13.34%PRS 99.59
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CSI 8.35rCSI 22.32%PRS 99.77
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CSI 7.81rCSI 55.84%PRS 99.62
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CSI 7.04rCSI 15.56%PRS 99.46
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CSI 6.98rCSI 32.84%PRS 99.46
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CSI 6.25rCSI 47.01%PRS 99.43
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CSI 5.74rCSI 65.78%PRS 99.27
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CSI 5.41rCSI 36.86%PRS 99.53
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CSI 5.19rCSI 40.18%PRS 99.63
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CSI 4.74rCSI 10.8%PRS 99.43
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CSI 4.14rCSI 34.86%PRS 99.47
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CSI 3.48rCSI 83.41%PRS 98.94
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CSI 3.45rCSI 83.13%PRS 98.88
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CSI 2.2rCSI 9.7%PRS 97.81
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
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Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 3910795295
Symbol: GRM5_HUMAN
Name: Metabotropic glutamate receptor 5
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7908515
Title: Molecular cloning and the functional expression of two isoforms of human metabotropic glutamate receptor subtype 5.
PubMed ID: 7908515
PubMed ID: 16554811
Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.
PubMed ID: 16554811
DOI: 10.1038/nature04632
PubMed ID: 7688218
Title: A variant of metabotropic glutamate receptor subtype 5: an evolutionally conserved insertion with no termination codon.
PubMed ID: 7688218
PubMed ID: 19694902
Title: The association of metabotropic glutamate receptor type 5 with the neuronal Ca2+-binding protein 2 modulates receptor function.
PubMed ID: 19694902
PubMed ID: 28130356
Title: Mutation Disrupts Dendritic Morphology and Synaptic Transmission, and Causes ASD-Related Behaviors.
PubMed ID: 28130356
PubMed ID: 25042998
Title: Structure of class C GPCR metabotropic glutamate receptor 5 transmembrane domain.
PubMed ID: 25042998
DOI: 10.1038/nature13396
Sequence Information:
- Length: 1212
- Mass: 132469
- Checksum: A3C73606681C6A25
- Sequence:
MVLLLILSVL LLKEDVRGSA QSSERRVVAH MPGDIIIGAL FSVHHQPTVD KVHERKCGAV REQYGIQRVE AMLHTLERIN SDPTLLPNIT LGCEIRDSCW HSAVALEQSI EFIRDSLISS EEEEGLVRCV DGSSSSFRSK KPIVGVIGPG SSSVAIQVQN LLQLFNIPQI AYSATSMDLS DKTLFKYFMR VVPSDAQQAR AMVDIVKRYN WTYVSAVHTE GNYGESGMEA FKDMSAKEGI CIAHSYKIYS NAGEQSFDKL LKKLTSHLPK ARVVACFCEG MTVRGLLMAM RRLGLAGEFL LLGSDGWADR YDVTDGYQRE AVGGITIKLQ SPDVKWFDDY YLKLRPETNH RNPWFQEFWQ HRFQCRLEGF PQENSKYNKT CNSSLTLKTH HVQDSKMGFV INAIYSMAYG LHNMQMSLCP GYAGLCDAMK PIDGRKLLES LMKTNFTGVS GDTILFDENG DSPGRYEIMN FKEMGKDYFD YINVGSWDNG ELKMDDDEVW SKKSNIIRSV CSEPCEKGQI KVIRKGEVSC CWTCTPCKEN EYVFDEYTCK ACQLGSWPTD DLTGCDLIPV QYLRWGDPEP IAAVVFACLG LLATLFVTVV FIIYRDTPVV KSSSRELCYI ILAGICLGYL CTFCLIAKPK QIYCYLQRIG IGLSPAMSYS ALVTKTNRIA RILAGSKKKI CTKKPRFMSA CAQLVIAFIL ICIQLGIIVA LFIMEPPDIM HDYPSIREVY LICNTTNLGV VTPLGYNGLL ILSCTFYAFK TRNVPANFNE AKYIAFTMYT TCIIWLAFVP IYFGSNYKII TMCFSVSLSA TVALGCMFVP KVYIILAKPE RNVRSAFTTS TVVRMHVGDG KSSSAASRSS SLVNLWKRRG SSGETLRYKD RRLAQHKSEI ECFTPKGSMG NGGRATMSSS NGKSVTWAQN EKSSRGQHLW QRLSIHINKK ENPNQTAVIK PFPKSTESRG LGAGAGAGGS AGGVGATGGA GCAGAGPGGP ESPDAGPKAL YDVAEAEEHF PAPARPRSPS PISTLSHRAG SASRTDDDVP SLHSEPVARS SSSQGSLMEQ ISSVVTRFTA NISELNSMML STAAPSPGVG APLCSSYLIP KEIQLPTTMT TFAEIQPLPA IEVTGGAQPA AGAQAAGDAA RESPAAGPEA AAAKPDLEEL VALTPPSPFR DSVDSGSTTP NSPVSESALC IPSSPKYDTL IIRDYTQSSS SL
Genular Protein ID: 1988594725
Symbol: A8K5P7_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 905
- Mass: 101417
- Checksum: 078564EFCC85E93B
- Sequence:
MVLLLILSVL LLKEDVRGSA QSSERRVVAH MPGDIIIGAL FSVHHQPTVD KVHERKCGAV REQYGIQRVE AMLHTLERIN SDPTLLPNIT LGCEIRDSCW HSAVALEQSI EFIRDSLISS EEEEGLVRCV DGSSSSFRSK KPIVGVIGPG SSSVAIQVQN LLQLFNIPQI AYSATSMDLS DKTLFKYFMR VVPSDAQQAR AMVDIVKRYN WTYVSAVHTE GNYGESGMEA FKDMSAKEGI CIAHSYKIYS NAGEQSFDKL LKKLTSHLPK ARVVACFCEG MTVRGLLMAM RRLGLAGEFL LLGSDGWADR YDVTDGYQRE AVGGITIKLQ SPDVKWFDDY YLKLRPETNH RNPWFQEFWQ HRFQCRLEGF PQENSKYNKT CNSSLTLKTH HVQDSKMGFV INAIYSMAYG LHNMQMSLCP GYAGLCDAMK PIDGRKLLES LMKTNFTGVS GDTILFDENG DSPGRYEIMN FKEMGKDYFD YINVGSWDNG ELKMDDDEVW SKKSNIIRSV CSEPCEKGQI KVIRKGEVSC CWTCTPCKEN EYVFDEYTCK ACQLGSWPTD DLTGCDLIPV QYLRWGDPEP IAAVVFACLG LLATLFVTVV FIIYRDTPVV KSSSRELCYI ILAGICLGYL CTFCLIAKPK QIYCYLQRIG IGLSPAMSYS ALVTKTNRIA RILAGSKKKI CTKKPRFMSA CAQLVIAFIL ICIQLGIIVA LFIMEPPDIM HDYPSIREVY LICNTTNLGV VTPLGYNGLL ILSCTFYAFK TRNVPANFNE AKYIAFTMYT TCIIWLAFVP IYFGSNYKII TMCFSVSLSA TVALGCMFVP KVYIILAKPE RNVRSAFTTS TVVRMHVGDG KSSSAASRSS SLVNLWKRRG SSGETLSSNG KSVTWAQNEK SSRGQHLWQR LSIHI