Details for: GRM5

Gene ID: 2915

Symbol: GRM5

Ensembl ID: ENSG00000168959

Description: glutamate metabotropic receptor 5

Associated with

  • Class c/3 (metabotropic glutamate/pheromone receptors)
    (R-HSA-420499)
  • G alpha (q) signalling events
    (R-HSA-416476)
  • Gpcr downstream signalling
    (R-HSA-388396)
  • Gpcr ligand binding
    (R-HSA-500792)
  • Neurexins and neuroligins
    (R-HSA-6794361)
  • Neuronal system
    (R-HSA-112316)
  • Protein-protein interactions at synapses
    (R-HSA-6794362)
  • Signaling by gpcr
    (R-HSA-372790)
  • Signal transduction
    (R-HSA-162582)
  • A2a adenosine receptor binding
    (GO:0031687)
  • Adenylate cyclase-inhibiting g protein-coupled glutamate receptor signaling pathway
    (GO:0007196)
  • Adenylate cyclase inhibiting g protein-coupled glutamate receptor activity
    (GO:0001640)
  • Astrocyte projection
    (GO:0097449)
  • Calcium-mediated signaling using intracellular calcium source
    (GO:0035584)
  • Cellular response to amyloid-beta
    (GO:1904646)
  • Chemical synaptic transmission
    (GO:0007268)
  • Cognition
    (GO:0050890)
  • Cytoplasm
    (GO:0005737)
  • Dendritic shaft
    (GO:0043198)
  • Dendritic spine
    (GO:0043197)
  • Desensitization of g protein-coupled receptor signaling pathway
    (GO:0002029)
  • Glutamate receptor activity
    (GO:0008066)
  • Glutamatergic synapse
    (GO:0098978)
  • G protein-coupled glutamate receptor signaling pathway
    (GO:0007216)
  • G protein-coupled receptor activity
    (GO:0004930)
  • G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential
    (GO:0099530)
  • Identical protein binding
    (GO:0042802)
  • Learning
    (GO:0007612)
  • Learning or memory
    (GO:0007611)
  • Locomotory behavior
    (GO:0007626)
  • Neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration
    (GO:0099583)
  • Phospholipase c-activating g protein-coupled glutamate receptor signaling pathway
    (GO:0007206)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of long-term neuronal synaptic plasticity
    (GO:0048170)
  • Positive regulation of mapk cascade
    (GO:0043410)
  • Positive regulation of protein tyrosine kinase activity
    (GO:0061098)
  • Postsynaptic density membrane
    (GO:0098839)
  • Protein binding
    (GO:0005515)
  • Protein kinase c-activating g protein-coupled receptor signaling pathway
    (GO:0007205)
  • Protein tyrosine kinase activator activity
    (GO:0030296)
  • Protein tyrosine kinase binding
    (GO:1990782)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of intracellular calcium activated chloride channel activity
    (GO:1902938)
  • Regulation of postsynaptic cytosolic calcium ion concentration
    (GO:0099566)
  • Regulation of postsynaptic membrane potential
    (GO:0060078)
  • Regulation of protein phosphorylation
    (GO:0001932)
  • Regulation of synaptic transmission, glutamatergic
    (GO:0051966)
  • Regulation of translation
    (GO:0006417)
  • Regulation of translational elongation
    (GO:0006448)
  • Schaffer collateral - ca1 synapse
    (GO:0098685)
  • Synapse organization
    (GO:0050808)
  • Trans-synaptic signaling by endocannabinoid, modulating synaptic transmission
    (GO:0099553)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 4.09
    Marker Score: 18904
  • Cell Name: neuron (CL0000540)
    Fold Change: 3.36
    Marker Score: 13686
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.94
    Marker Score: 4929
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.91
    Marker Score: 57808
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 2.87
    Marker Score: 8201.5
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.85
    Marker Score: 42657
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.62
    Marker Score: 10845
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.45
    Marker Score: 90547
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.41
    Marker Score: 928
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.34
    Marker Score: 9064
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 2.32
    Marker Score: 2865
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.22
    Marker Score: 16989
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.2
    Marker Score: 20682
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.12
    Marker Score: 71543
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 2.09
    Marker Score: 3954
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.08
    Marker Score: 127880
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.93
    Marker Score: 18326
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.92
    Marker Score: 3503
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.92
    Marker Score: 19814
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.9
    Marker Score: 72059
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.88
    Marker Score: 16171
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.66
    Marker Score: 2560
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.54
    Marker Score: 3128
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.47
    Marker Score: 6114
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.45
    Marker Score: 166173
  • Cell Name: granule cell (CL0000120)
    Fold Change: 1.37
    Marker Score: 10325
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 1.34
    Marker Score: 3072
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.33
    Marker Score: 597
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.32
    Marker Score: 793
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.31
    Marker Score: 686
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.31
    Marker Score: 1506
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.3
    Marker Score: 1127
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 1.24
    Marker Score: 6677
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.2
    Marker Score: 696
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.11
    Marker Score: 23664
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.08
    Marker Score: 643
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.05
    Marker Score: 428
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.04
    Marker Score: 6894
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71795
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1
    Marker Score: 2536
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48020
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.99
    Marker Score: 451
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.97
    Marker Score: 1046
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.95
    Marker Score: 1066
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5348
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.94
    Marker Score: 615.5
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.92
    Marker Score: 14395
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.89
    Marker Score: 2088
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5285
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 0.85
    Marker Score: 259
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.85
    Marker Score: 5118
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.79
    Marker Score: 7997
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1265
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 709
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.76
    Marker Score: 2619
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.74
    Marker Score: 192
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.71
    Marker Score: 222
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.68
    Marker Score: 323
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.64
    Marker Score: 1096
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.63
    Marker Score: 1519.5
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.62
    Marker Score: 223
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.6
    Marker Score: 264
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.59
    Marker Score: 473
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.57
    Marker Score: 685
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.56
    Marker Score: 196
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.56
    Marker Score: 315
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.55
    Marker Score: 608
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.55
    Marker Score: 192
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.46
    Marker Score: 227
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.44
    Marker Score: 257
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.42
    Marker Score: 133
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.42
    Marker Score: 152
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 0.39
    Marker Score: 1308
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.36
    Marker Score: 1277
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.36
    Marker Score: 246
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 0.35
    Marker Score: 99
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.33
    Marker Score: 364
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.32
    Marker Score: 119
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.31
    Marker Score: 280
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 0.31
    Marker Score: 150
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.31
    Marker Score: 126
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.3
    Marker Score: 369
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.29
    Marker Score: 549
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.29
    Marker Score: 58
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.28
    Marker Score: 275
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.27
    Marker Score: 252
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.27
    Marker Score: 2352
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.27
    Marker Score: 1397
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.26
    Marker Score: 3521.5
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.26
    Marker Score: 77
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.26
    Marker Score: 124
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.26
    Marker Score: 127.5
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.25
    Marker Score: 147
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.24
    Marker Score: 307
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.23
    Marker Score: 57
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.23
    Marker Score: 706
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.23
    Marker Score: 58

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Other Information

**Key characteristics:** - GRM5 is a member of the glutamate receptor family of ion channels. - It is a G protein-coupled receptor, meaning that it couples to G proteins, which are signaling molecules that transmit signals from the receptor to other cellular components. - GRM5 is expressed in a variety of brain regions, including inhibitory interneurons, neurons, and pyramidal neurons. - It is particularly abundant in inhibitory interneurons, where it is involved in regulating synaptic plasticity and learning and memory processes. **Pathways and functions:** - GRM5 is primarily expressed on the surface of neurons and is a ligand for the neurotransmitter glutamate. - Upon binding to glutamate, GRM5 undergoes conformational changes that allow it to interact with G proteins. - The binding of G proteins to GRM5 activates them, leading to the closure of ligand-gated ion channels and the depolarization of the neuron. - This change in membrane potential can either inhibit or excite postsynaptic neurons, depending on the context. - GRM5 is also involved in regulating calcium signaling, as it can interact with calcium channels and modulate their activity. **Clinical significance:** - Mutations in GRM5 have been linked to several neurological disorders, including autism, schizophrenia, and epilepsy. - In particular, GRM5 mutations are thought to be involved in the pathogenesis of autism spectrum disorder (ASD), a neurodevelopmental disorder characterized by social and communication deficits. - Genetic studies have identified GRM5 as a potential therapeutic target for ASD, as it is highly expressed in the brain regions implicated in the disease. - Drugs that block GRM5 activity have shown promise in preclinical models of ASD, suggesting that targeting this receptor could be a potential therapeutic strategy for this disorder.

Genular Protein ID: 3910795295

Symbol: GRM5_HUMAN

Name: Metabotropic glutamate receptor 5

UniProtKB Accession Codes:

P41594 Q6J164

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChEBI 6 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 DrugCentral 1 EMBL 10 EMDB 16 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 39 Gene3D 2 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 19 PDBsum 15 PIR 2 PRINTS 3 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 3 RefSeq 5 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7908515

Title: Molecular cloning and the functional expression of two isoforms of human metabotropic glutamate receptor subtype 5.

PubMed ID: 7908515

DOI: 10.1006/bbrc.1994.1349

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 7688218

Title: A variant of metabotropic glutamate receptor subtype 5: an evolutionally conserved insertion with no termination codon.

PubMed ID: 7688218

DOI: 10.1006/bbrc.1993.1866

PubMed ID: 19694902

Title: The association of metabotropic glutamate receptor type 5 with the neuronal Ca2+-binding protein 2 modulates receptor function.

PubMed ID: 19694902

DOI: 10.1111/j.1471-4159.2009.06348.x

PubMed ID: 28130356

Title: Mutation Disrupts Dendritic Morphology and Synaptic Transmission, and Causes ASD-Related Behaviors.

PubMed ID: 28130356

DOI: 10.1523/jneurosci.2068-16.2017

PubMed ID: 25042998

Title: Structure of class C GPCR metabotropic glutamate receptor 5 transmembrane domain.

PubMed ID: 25042998

DOI: 10.1038/nature13396

Sequence Information:

  • Length: 1212
  • Mass: 132469
  • Checksum: A3C73606681C6A25
  • Sequence:
    • MVLLLILSVL LLKEDVRGSA QSSERRVVAH MPGDIIIGAL FSVHHQPTVD KVHERKCGAV 
REQYGIQRVE AMLHTLERIN SDPTLLPNIT LGCEIRDSCW HSAVALEQSI EFIRDSLISS 
EEEEGLVRCV DGSSSSFRSK KPIVGVIGPG SSSVAIQVQN LLQLFNIPQI AYSATSMDLS 
DKTLFKYFMR VVPSDAQQAR AMVDIVKRYN WTYVSAVHTE GNYGESGMEA FKDMSAKEGI 
CIAHSYKIYS NAGEQSFDKL LKKLTSHLPK ARVVACFCEG MTVRGLLMAM RRLGLAGEFL 
LLGSDGWADR YDVTDGYQRE AVGGITIKLQ SPDVKWFDDY YLKLRPETNH RNPWFQEFWQ 
HRFQCRLEGF PQENSKYNKT CNSSLTLKTH HVQDSKMGFV INAIYSMAYG LHNMQMSLCP 
GYAGLCDAMK PIDGRKLLES LMKTNFTGVS GDTILFDENG DSPGRYEIMN FKEMGKDYFD 
YINVGSWDNG ELKMDDDEVW SKKSNIIRSV CSEPCEKGQI KVIRKGEVSC CWTCTPCKEN 
EYVFDEYTCK ACQLGSWPTD DLTGCDLIPV QYLRWGDPEP IAAVVFACLG LLATLFVTVV 
FIIYRDTPVV KSSSRELCYI ILAGICLGYL CTFCLIAKPK QIYCYLQRIG IGLSPAMSYS 
ALVTKTNRIA RILAGSKKKI CTKKPRFMSA CAQLVIAFIL ICIQLGIIVA LFIMEPPDIM 
HDYPSIREVY LICNTTNLGV VTPLGYNGLL ILSCTFYAFK TRNVPANFNE AKYIAFTMYT 
TCIIWLAFVP IYFGSNYKII TMCFSVSLSA TVALGCMFVP KVYIILAKPE RNVRSAFTTS 
TVVRMHVGDG KSSSAASRSS SLVNLWKRRG SSGETLRYKD RRLAQHKSEI ECFTPKGSMG 
NGGRATMSSS NGKSVTWAQN EKSSRGQHLW QRLSIHINKK ENPNQTAVIK PFPKSTESRG 
LGAGAGAGGS AGGVGATGGA GCAGAGPGGP ESPDAGPKAL YDVAEAEEHF PAPARPRSPS 
PISTLSHRAG SASRTDDDVP SLHSEPVARS SSSQGSLMEQ ISSVVTRFTA NISELNSMML 
STAAPSPGVG APLCSSYLIP KEIQLPTTMT TFAEIQPLPA IEVTGGAQPA AGAQAAGDAA 
RESPAAGPEA AAAKPDLEEL VALTPPSPFR DSVDSGSTTP NSPVSESALC IPSSPKYDTL 
IIRDYTQSSS SL

Genular Protein ID: 1988594725

Symbol: A8K5P7_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K5P7

Database IDs:

ARBA 11 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 DNASU 1 EMBL 2 GO 3 Gene3D 2 Genevisible 1 GenomeRNAi 1 InterPro 9 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 3 PROSITE 5 PeptideAtlas 1 Pfam 3 PharmGKB 1 RefSeq 1 SAM 2 SUPFAM 1

Sequence Information:

  • Length: 905
  • Mass: 101417
  • Checksum: 078564EFCC85E93B
  • Sequence:
    • MVLLLILSVL LLKEDVRGSA QSSERRVVAH MPGDIIIGAL FSVHHQPTVD KVHERKCGAV 
REQYGIQRVE AMLHTLERIN SDPTLLPNIT LGCEIRDSCW HSAVALEQSI EFIRDSLISS 
EEEEGLVRCV DGSSSSFRSK KPIVGVIGPG SSSVAIQVQN LLQLFNIPQI AYSATSMDLS 
DKTLFKYFMR VVPSDAQQAR AMVDIVKRYN WTYVSAVHTE GNYGESGMEA FKDMSAKEGI 
CIAHSYKIYS NAGEQSFDKL LKKLTSHLPK ARVVACFCEG MTVRGLLMAM RRLGLAGEFL 
LLGSDGWADR YDVTDGYQRE AVGGITIKLQ SPDVKWFDDY YLKLRPETNH RNPWFQEFWQ 
HRFQCRLEGF PQENSKYNKT CNSSLTLKTH HVQDSKMGFV INAIYSMAYG LHNMQMSLCP 
GYAGLCDAMK PIDGRKLLES LMKTNFTGVS GDTILFDENG DSPGRYEIMN FKEMGKDYFD 
YINVGSWDNG ELKMDDDEVW SKKSNIIRSV CSEPCEKGQI KVIRKGEVSC CWTCTPCKEN 
EYVFDEYTCK ACQLGSWPTD DLTGCDLIPV QYLRWGDPEP IAAVVFACLG LLATLFVTVV 
FIIYRDTPVV KSSSRELCYI ILAGICLGYL CTFCLIAKPK QIYCYLQRIG IGLSPAMSYS 
ALVTKTNRIA RILAGSKKKI CTKKPRFMSA CAQLVIAFIL ICIQLGIIVA LFIMEPPDIM 
HDYPSIREVY LICNTTNLGV VTPLGYNGLL ILSCTFYAFK TRNVPANFNE AKYIAFTMYT 
TCIIWLAFVP IYFGSNYKII TMCFSVSLSA TVALGCMFVP KVYIILAKPE RNVRSAFTTS 
TVVRMHVGDG KSSSAASRSS SLVNLWKRRG SSGETLSSNG KSVTWAQNEK SSRGQHLWQR 
LSIHI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.