Details for: ND4
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 890.1289
Cell Significance Index: -420.2500 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 836.9019
Cell Significance Index: -430.4900 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 628.8466
Cell Significance Index: -421.9700 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 87.6791
Cell Significance Index: -234.8800 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 60.6043
Cell Significance Index: 2224.7400 - Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 52.0179
Cell Significance Index: 413.8800 - Cell Name: Sertoli cell (CL0000216)
Fold Change: 49.2002
Cell Significance Index: 690.1100 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: 32.4059
Cell Significance Index: 2566.5500 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 32.3189
Cell Significance Index: 23696.1300 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 32.1842
Cell Significance Index: 475.0400 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 32.1151
Cell Significance Index: 9240.4700 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 19.5917
Cell Significance Index: 1028.6400 - Cell Name: abnormal cell (CL0001061)
Fold Change: 16.6342
Cell Significance Index: 1699.1800 - Cell Name: pro-T cell (CL0000827)
Fold Change: 12.6055
Cell Significance Index: 322.0300 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 12.0459
Cell Significance Index: 327.8800 - Cell Name: cell in vitro (CL0001034)
Fold Change: 11.1931
Cell Significance Index: 6112.8300 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 10.3442
Cell Significance Index: 276.7000 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 9.9824
Cell Significance Index: 91.9300 - Cell Name: seromucus secreting cell (CL0000159)
Fold Change: 9.4799
Cell Significance Index: 197.7100 - Cell Name: granulosa cell (CL0000501)
Fold Change: 9.2307
Cell Significance Index: 242.7200 - Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: 8.8948
Cell Significance Index: 68.5600 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 8.6970
Cell Significance Index: 1194.3400 - Cell Name: odontoblast (CL0000060)
Fold Change: 8.3511
Cell Significance Index: 1070.5600 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 8.1788
Cell Significance Index: 123.2500 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 7.9335
Cell Significance Index: 228.5800 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 7.9217
Cell Significance Index: 861.6400 - Cell Name: lactocyte (CL0002325)
Fold Change: 7.7664
Cell Significance Index: 1003.3700 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 7.6748
Cell Significance Index: 943.6900 - Cell Name: peg cell (CL4033014)
Fold Change: 7.6495
Cell Significance Index: 176.7300 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 7.3677
Cell Significance Index: 333.9600 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 6.8564
Cell Significance Index: 511.0000 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 6.2227
Cell Significance Index: 401.4600 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 5.9266
Cell Significance Index: 586.2700 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 5.9226
Cell Significance Index: 4482.9400 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 5.9192
Cell Significance Index: 205.6900 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 5.8481
Cell Significance Index: 1054.2300 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 5.3335
Cell Significance Index: 248.6800 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 5.2301
Cell Significance Index: 245.8100 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 4.3149
Cell Significance Index: 79.7500 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 4.1975
Cell Significance Index: 3790.0700 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 4.1755
Cell Significance Index: 679.1000 - Cell Name: enterocyte (CL0000584)
Fold Change: 4.0764
Cell Significance Index: 25.2900 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 3.6375
Cell Significance Index: 104.2700 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 3.1821
Cell Significance Index: 36.1500 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 2.9588
Cell Significance Index: 52.2900 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 2.2809
Cell Significance Index: 818.1400 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 2.2395
Cell Significance Index: 37.7300 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.9290
Cell Significance Index: 382.8200 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.8015
Cell Significance Index: 108.1500 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 1.2994
Cell Significance Index: 247.2900 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 1.0679
Cell Significance Index: 37.5300 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.9084
Cell Significance Index: 182.2300 - Cell Name: preadipocyte (CL0002334)
Fold Change: 0.5487
Cell Significance Index: 10.7100 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.4320
Cell Significance Index: 22.4400 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.3191
Cell Significance Index: 8.5200 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.1963
Cell Significance Index: -369.6900 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.3051
Cell Significance Index: -562.6000 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.3679
Cell Significance Index: -566.3400 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.3859
Cell Significance Index: -65.9000 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.4184
Cell Significance Index: -568.9300 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.5099
Cell Significance Index: -377.7200 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.6168
Cell Significance Index: -391.7300 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.7037
Cell Significance Index: -396.8500 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.7487
Cell Significance Index: -50.3400 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.8201
Cell Significance Index: -512.1300 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.8387
Cell Significance Index: -380.6400 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.8530
Cell Significance Index: -58.9900 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -1.6249
Cell Significance Index: -186.1600 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -2.2224
Cell Significance Index: -468.0900 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -2.4111
Cell Significance Index: -60.2700 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -2.4513
Cell Significance Index: -78.5100 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -2.9160
Cell Significance Index: -85.6400 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -3.0310
Cell Significance Index: -440.5900 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -3.2783
Cell Significance Index: -54.8700 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -3.3636
Cell Significance Index: -188.7500 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -3.3774
Cell Significance Index: -73.1700 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -3.7347
Cell Significance Index: -388.8700 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -4.0642
Cell Significance Index: -85.0700 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -4.4886
Cell Significance Index: -344.4500 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -4.5920
Cell Significance Index: -289.4200 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -4.8467
Cell Significance Index: -138.3100 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -5.2407
Cell Significance Index: -322.1200 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -5.4127
Cell Significance Index: -273.5500 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -5.7856
Cell Significance Index: -354.7100 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -6.2312
Cell Significance Index: -255.3300 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -6.4175
Cell Significance Index: -96.1600 - Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -6.7203
Cell Significance Index: -115.8500 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -7.6991
Cell Significance Index: -98.6000 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -7.8570
Cell Significance Index: -81.3400 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -8.7505
Cell Significance Index: -257.7400 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -8.8256
Cell Significance Index: -187.9600 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -9.3502
Cell Significance Index: -413.5800 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -10.4798
Cell Significance Index: -124.9300 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -10.5092
Cell Significance Index: -270.1400 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -10.6994
Cell Significance Index: -221.9500 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -11.0799
Cell Significance Index: -388.1500 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -11.3609
Cell Significance Index: -430.2100 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -11.6695
Cell Significance Index: -382.0600 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -11.9502
Cell Significance Index: -380.6000 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -12.9159
Cell Significance Index: -176.2200
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3412048835
Symbol: NU4M_HUMAN
Name: NADH-ubiquinone oxidoreductase chain 4
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7219534
Title: Sequence and organization of the human mitochondrial genome.
PubMed ID: 7219534
DOI: 10.1038/290457a0
PubMed ID: 1377597
Title: Differentiation of HT-29 human colonic adenocarcinoma cells correlates with increased expression of mitochondrial RNA: effects of trehalose on cell growth and maturation.
PubMed ID: 1377597
PubMed ID: 12022039
Title: Mitochondrial genome diversity of native Americans supports a single early entry of founder populations into America.
PubMed ID: 12022039
DOI: 10.1086/341358
PubMed ID: 12949126
Title: Lineage-specific selection in human mtDNA: lack of polymorphisms in a segment of MTND5 gene in haplogroup J.
PubMed ID: 12949126
PubMed ID: 11130070
Title: Mitochondrial genome variation and the origin of modern humans.
PubMed ID: 11130070
DOI: 10.1038/35047064
PubMed ID: 12840039
Title: Mitochondrial genome variation and evolutionary history of Australian and New Guinean aborigines.
PubMed ID: 12840039
DOI: 10.1101/gr.686603
PubMed ID: 14760490
Title: Single nucleotide polymorphisms over the entire mtDNA genome that increase the power of forensic testing in Caucasians.
PubMed ID: 14760490
PubMed ID: 6284948
Title: Mitochondrial DNA sequences of primates: tempo and mode of evolution.
PubMed ID: 6284948
DOI: 10.1007/bf01734101
PubMed ID: 3921850
Title: Six unidentified reading frames of human mitochondrial DNA encode components of the respiratory-chain NADH dehydrogenase.
PubMed ID: 3921850
DOI: 10.1038/314592a0
PubMed ID: 8344246
Title: Lack of assembly of mitochondrial DNA-encoded subunits of respiratory NADH dehydrogenase and loss of enzyme activity in a human cell mutant lacking the mitochondrial ND4 gene product.
PubMed ID: 8344246
PubMed ID: 12611891
Title: The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification.
PubMed ID: 12611891
PubMed ID: 15250827
Title: Structural organization of mitochondrial human complex I: role of the ND4 and ND5 mitochondria-encoded subunits and interaction with prohibitin.
PubMed ID: 15250827
DOI: 10.1042/bj20040256
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 3201231
Title: Mitochondrial DNA mutation associated with Leber's hereditary optic neuropathy.
PubMed ID: 3201231
PubMed ID: 1959619
Title: Electron transfer properties of NADH:ubiquinone reductase in the ND1/3460 and the ND4/11778 mutations of the Leber hereditary optic neuroretinopathy (LHON).
PubMed ID: 1959619
PubMed ID: 1959931
Title: Detection of the G to A mitochondrial DNA mutation at position 11778 in German families with Leber's hereditary optic neuropathy.
PubMed ID: 1959931
DOI: 10.1007/bf00204937
PubMed ID: 1757091
Title: Normal variants of human mitochondrial DNA and translation products: the building of a reference data base.
PubMed ID: 1757091
DOI: 10.1007/bf00206061
PubMed ID: 1323207
Title: A new disease-related mutation for mitochondrial encephalopathy lactic acidosis and strokelike episodes (MELAS) syndrome affects the ND4 subunit of the respiratory complex I.
PubMed ID: 1323207
PubMed ID: 8644732
Title: Genetic and biochemical impairment of mitochondrial complex I activity in a family with Leber hereditary optic neuropathy and hereditary spastic dystonia.
PubMed ID: 8644732
PubMed ID: 9452107
Title: Leber's hereditary optic neuropathy in Indonesia: two families with the mtDNA 11778G>A and 14484T>C mutations.
PubMed ID: 9452107
PubMed ID: 20818383
Title: High-throughput, pooled sequencing identifies mutations in NUBPL and FOXRED1 in human complex I deficiency.
PubMed ID: 20818383
DOI: 10.1038/ng.659
Sequence Information:
- Length: 459
- Mass: 51581
- Checksum: 2EEE581F3BD270AF
- Sequence:
MLKLIVPTIM LLPLTWLSKK HMIWINTTTH SLIISIIPLL FFNQINNNLF SCSPTFSSDP LTTPLLMLTT WLLPLTIMAS QRHLSSEPLS RKKLYLSMLI SLQISLIMTF TATELIMFYI FFETTLIPTL AIITRWGNQP ERLNAGTYFL FYTLVGSLPL LIALIYTHNT LGSLNILLLT LTAQELSNSW ANNLMWLAYT MAFMVKMPLY GLHLWLPKAH VEAPIAGSMV LAAVLLKLGG YGMMRLTLIL NPLTKHMAYP FLVLSLWGMI MTSSICLRQT DLKSLIAYSS ISHMALVVTA ILIQTPWSFT GAVILMIAHG LTSSLLFCLA NSNYERTHSR IMILSQGLQT LLPLMAFWWL LASLANLALP PTINLLGELS VLVTTFSWSN ITLLLTGLNM LVTALYSLYM FTTTQWGSLT HHINNMKPSF TRENTLMFMH LSPILLLSLN PDIITGFSS
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.