Details for: ND1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 837.8930
Cell Significance Index: -340.4000 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 778.3782
Cell Significance Index: -367.4900 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 731.3001
Cell Significance Index: -376.1700 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 549.6540
Cell Significance Index: -368.8300 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 359.3952
Cell Significance Index: -343.1300 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 85.8052
Cell Significance Index: -229.8600 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 51.6123
Cell Significance Index: 1894.6500 - Cell Name: Sertoli cell (CL0000216)
Fold Change: 48.9386
Cell Significance Index: 686.4400 - Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 34.2111
Cell Significance Index: 272.2000 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: 33.4270
Cell Significance Index: 2647.4200 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 29.0119
Cell Significance Index: 21271.4500 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 27.5056
Cell Significance Index: 405.9800 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 24.8828
Cell Significance Index: 7159.5300 - Cell Name: abnormal cell (CL0001061)
Fold Change: 16.3220
Cell Significance Index: 1667.2900 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 13.2731
Cell Significance Index: 696.8900 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 10.5519
Cell Significance Index: 287.2200 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 10.0394
Cell Significance Index: 522.9400 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 9.6384
Cell Significance Index: 257.8200 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 9.5536
Cell Significance Index: 176.5800 - Cell Name: cell in vitro (CL0001034)
Fold Change: 8.4913
Cell Significance Index: 4637.3100 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 8.2783
Cell Significance Index: 900.4200 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 8.2428
Cell Significance Index: 7442.6500 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 7.9895
Cell Significance Index: 1097.1800 - Cell Name: peg cell (CL4033014)
Fold Change: 7.7984
Cell Significance Index: 180.1700 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 7.4691
Cell Significance Index: 215.2000 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 7.1738
Cell Significance Index: 534.6600 - Cell Name: pro-T cell (CL0000827)
Fold Change: 7.0383
Cell Significance Index: 179.8100 - Cell Name: odontoblast (CL0000060)
Fold Change: 7.0263
Cell Significance Index: 900.7300 - Cell Name: seromucus secreting cell (CL0000159)
Fold Change: 6.9154
Cell Significance Index: 144.2300 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 6.8305
Cell Significance Index: 62.9000 - Cell Name: lactocyte (CL0002325)
Fold Change: 6.3227
Cell Significance Index: 816.8500 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 5.7845
Cell Significance Index: 373.1900 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 5.4577
Cell Significance Index: 671.0700 - Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: 5.4165
Cell Significance Index: 41.7500 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 5.3736
Cell Significance Index: 250.5400 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 4.4254
Cell Significance Index: 3349.6900 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 4.3267
Cell Significance Index: 196.1200 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 4.3176
Cell Significance Index: 49.0500 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 3.9591
Cell Significance Index: 643.9100 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 3.7977
Cell Significance Index: 57.2300 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 3.7756
Cell Significance Index: 131.2000 - Cell Name: granulosa cell (CL0000501)
Fold Change: 3.6574
Cell Significance Index: 96.1700 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 3.4252
Cell Significance Index: 160.9800 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 3.3072
Cell Significance Index: 327.1600 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 3.2984
Cell Significance Index: 594.5900 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 3.2742
Cell Significance Index: 57.8600 - Cell Name: preadipocyte (CL0002334)
Fold Change: 2.1827
Cell Significance Index: 42.6000 - Cell Name: enterocyte (CL0000584)
Fold Change: 1.9633
Cell Significance Index: 12.1800 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 1.9424
Cell Significance Index: 32.7200 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.7410
Cell Significance Index: 624.4600 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.4348
Cell Significance Index: 284.7400 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.2352
Cell Significance Index: 247.7800 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.0655
Cell Significance Index: 55.3500 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 1.0206
Cell Significance Index: 194.2300 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.9927
Cell Significance Index: 28.4600 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.7924
Cell Significance Index: 27.8500 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.3371
Cell Significance Index: 20.2400 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.2359
Cell Significance Index: 6.3000 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.1765
Cell Significance Index: -332.2400 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.1889
Cell Significance Index: -32.2600 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.2357
Cell Significance Index: -434.7200 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.2825
Cell Significance Index: -434.9400 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.3211
Cell Significance Index: -436.6600 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.3971
Cell Significance Index: -294.1300 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.5127
Cell Significance Index: -325.6200 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.5479
Cell Significance Index: -309.0000 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.6518
Cell Significance Index: -407.0300 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.7009
Cell Significance Index: -318.1300 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -1.0239
Cell Significance Index: -68.8500 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -1.1393
Cell Significance Index: -130.5200 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -1.3577
Cell Significance Index: -39.8800 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -1.7504
Cell Significance Index: -368.6800 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -2.0434
Cell Significance Index: -141.3100 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -2.1312
Cell Significance Index: -53.2800 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -2.4388
Cell Significance Index: -354.5100 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -2.4669
Cell Significance Index: -79.0100 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -2.7883
Cell Significance Index: -46.6700 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -3.3850
Cell Significance Index: -352.4600 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -3.3929
Cell Significance Index: -190.3900 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -3.5613
Cell Significance Index: -224.4600 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -3.7434
Cell Significance Index: -81.1000 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -4.0883
Cell Significance Index: -313.7300 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -4.8774
Cell Significance Index: -299.0300 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -5.0082
Cell Significance Index: -104.8300 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -5.1278
Cell Significance Index: -65.6700 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -5.1537
Cell Significance Index: -147.0700 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -5.1976
Cell Significance Index: -319.4700 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -5.2176
Cell Significance Index: -111.1200 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -5.3597
Cell Significance Index: -80.3100 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -6.3831
Cell Significance Index: -261.5500 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -6.9015
Cell Significance Index: -305.2700 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -7.1742
Cell Significance Index: -211.3100 - Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -7.3079
Cell Significance Index: -125.9800 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -8.4886
Cell Significance Index: -321.4400 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -8.6718
Cell Significance Index: -89.7700 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -9.0532
Cell Significance Index: -107.9200 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -9.0699
Cell Significance Index: -458.3700 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -9.4996
Cell Significance Index: -197.0600 - Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: -9.7067
Cell Significance Index: -83.4100 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -9.8500
Cell Significance Index: -345.0700
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1697787257
Symbol: NU1M_HUMAN
Name: NADH-ubiquinone oxidoreductase chain 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7219534
Title: Sequence and organization of the human mitochondrial genome.
PubMed ID: 7219534
DOI: 10.1038/290457a0
PubMed ID: 7530363
Title: Recent African origin of modern humans revealed by complete sequences of hominoid mitochondrial DNAs.
PubMed ID: 7530363
PubMed ID: 12949126
Title: Lineage-specific selection in human mtDNA: lack of polymorphisms in a segment of MTND5 gene in haplogroup J.
PubMed ID: 12949126
PubMed ID: 11130070
Title: Mitochondrial genome variation and the origin of modern humans.
PubMed ID: 11130070
DOI: 10.1038/35047064
PubMed ID: 12840039
Title: Mitochondrial genome variation and evolutionary history of Australian and New Guinean aborigines.
PubMed ID: 12840039
DOI: 10.1101/gr.686603
PubMed ID: 14760490
Title: Single nucleotide polymorphisms over the entire mtDNA genome that increase the power of forensic testing in Caucasians.
PubMed ID: 14760490
PubMed ID: 19243582
Title: Mitochondrial DNA haplogroup H structure in North Africa.
PubMed ID: 19243582
PubMed ID: 6260957
Title: Cloning in single-stranded bacteriophage as an aid to rapid DNA sequencing.
PubMed ID: 6260957
PubMed ID: 3921850
Title: Six unidentified reading frames of human mitochondrial DNA encode components of the respiratory-chain NADH dehydrogenase.
PubMed ID: 3921850
DOI: 10.1038/314592a0
PubMed ID: 12611891
Title: The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification.
PubMed ID: 12611891
PubMed ID: 15265369
Title: Relationship between mutations of mitochondrial DNA ND1 gene and type 2 diabetes.
PubMed ID: 15265369
PubMed ID: 26929434
Title: Loss of mitochondrial DNA-encoded protein ND1 results in disruption of complex I biogenesis during early stages of assembly.
PubMed ID: 26929434
PubMed ID: 24105702
Title: Whole-exome sequencing identifies a variant of the mitochondrial MT-ND1 gene associated with epileptic encephalopathy: west syndrome evolving to Lennox-Gastaut syndrome.
PubMed ID: 24105702
DOI: 10.1002/humu.22445
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 1928099
Title: Leber hereditary optic neuropathy: identification of the same mitochondrial ND1 mutation in six pedigrees.
PubMed ID: 1928099
PubMed ID: 1674640
Title: A new mtDNA mutation associated with Leber hereditary optic neuroretinopathy.
PubMed ID: 1674640
PubMed ID: 2018041
Title: Leber hereditary optic neuropathy: involvement of the mitochondrial ND1 gene and evidence for an intragenic suppressor mutation.
PubMed ID: 2018041
PubMed ID: 1900003
Title: Alternative, simultaneous complex I mitochondrial DNA mutations in Leber's hereditary optic neuropathy.
PubMed ID: 1900003
PubMed ID: 1959619
Title: Electron transfer properties of NADH:ubiquinone reductase in the ND1/3460 and the ND4/11778 mutations of the Leber hereditary optic neuroretinopathy (LHON).
PubMed ID: 1959619
PubMed ID: 1757091
Title: Normal variants of human mitochondrial DNA and translation products: the building of a reference data base.
PubMed ID: 1757091
DOI: 10.1007/bf00206061
PubMed ID: 1417830
Title: An ND-6 mitochondrial DNA mutation associated with Leber hereditary optic neuropathy.
PubMed ID: 1417830
PubMed ID: 8104867
Title: Mitochondrial DNA variants observed in Alzheimer disease and Parkinson disease patients.
PubMed ID: 8104867
PubMed ID: 8723687
Title: A novel combination of mitochondrial tRNA and ND1 gene mutations in a syndrome with MELAS, cardiomyopathy, and diabetes mellitus.
PubMed ID: 8723687
DOI: 10.1002/(sici)1098-1004(1996)7:4<358::aid-humu11>3.0.co;2-1
PubMed ID: 7733935
Title: A new mitochondrial DNA mutation associated with non-insulin-dependent diabetes mellitus.
PubMed ID: 7733935
PubMed ID: 21144833
Title: A novel m.3395A>G missense mutation in the mitochondrial ND1 gene associated with the new tRNA(Ile) m.4316A>G mutation in a patient with hypertrophic cardiomyopathy and profound hearing loss.
PubMed ID: 21144833
Sequence Information:
- Length: 318
- Mass: 35661
- Checksum: 2F771ACB95002591
- Sequence:
MPMANLLLLI VPILIAMAFL MLTERKILGY MQLRKGPNVV GPYGLLQPFA DAMKLFTKEP LKPATSTITL YITAPTLALT IALLLWTPLP MPNPLVNLNL GLLFILATSS LAVYSILWSG WASNSNYALI GALRAVAQTI SYEVTLAIIL LSTLLMSGSF NLSTLITTQE HLWLLLPSWP LAMMWFISTL AETNRTPFDL AEGESELVSG FNIEYAAGPF ALFFMAEYTN IIMMNTLTTT IFLGTTYDAL SPELYTTYFV TKTLLLTSLF LWIRTAYPRF RYDQLMHLLW KNFLPLTLAL LMWYVSMPIT ISSIPPQT
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.