Details for: HLA E

Gene ID: 3133

Symbol: HLA E

Ensembl ID: ENSG00000204592

Description: major histocompatibility complex, class I, E

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 5.89
    Marker Score: 14,963
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 5.27
    Marker Score: 3,721
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 5.24
    Marker Score: 15,280
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 5.2
    Marker Score: 51,496
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 4.94
    Marker Score: 4,196
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 4.88
    Marker Score: 15,409
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 4.77
    Marker Score: 19,817
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 4.66
    Marker Score: 246,419
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 4.64
    Marker Score: 6,715
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 4.61
    Marker Score: 2,972
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 4.33
    Marker Score: 2,626
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 4.29
    Marker Score: 12,021
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 4.26
    Marker Score: 7,305
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 4.23
    Marker Score: 4,092
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 4.23
    Marker Score: 8,873
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 4.22
    Marker Score: 3,063
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 4.2
    Marker Score: 234,638
  • Cell Name: blood cell (CL0000081)
    Fold Change: 4.18
    Marker Score: 48,589
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 4.16
    Marker Score: 11,495
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 4.09
    Marker Score: 3,523
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 4.08
    Marker Score: 17,497
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 4.08
    Marker Score: 9,948
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 4.02
    Marker Score: 5,927
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 3.96
    Marker Score: 3,905
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.93
    Marker Score: 133,552
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 3.93
    Marker Score: 2,017
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 3.92
    Marker Score: 4,360
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 3.86
    Marker Score: 3,444
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 3.82
    Marker Score: 1,242
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 3.79
    Marker Score: 3,368
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 3.77
    Marker Score: 3,171
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 3.71
    Marker Score: 2,281
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 3.69
    Marker Score: 2,247
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 3.68
    Marker Score: 3,598
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 3.67
    Marker Score: 3,451
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 3.66
    Marker Score: 1,074
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 3.59
    Marker Score: 6,409
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 3.57
    Marker Score: 2,805
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 3.56
    Marker Score: 2,428
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 3.56
    Marker Score: 3,128
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 3.55
    Marker Score: 1,527
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 3.54
    Marker Score: 3,163
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 3.53
    Marker Score: 3,012
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 3.52
    Marker Score: 2,667
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 3.44
    Marker Score: 4,751
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.41
    Marker Score: 3,644
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 3.39
    Marker Score: 2,485
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 3.31
    Marker Score: 1,848
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 3.3
    Marker Score: 768
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 3.3
    Marker Score: 3,090
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 3.3
    Marker Score: 3,551
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 3.3
    Marker Score: 6,590
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 3.29
    Marker Score: 44,230
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 3.28
    Marker Score: 2,687
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 3.27
    Marker Score: 2,474
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.26
    Marker Score: 7,972
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 3.26
    Marker Score: 3,734
  • Cell Name: platelet (CL0000233)
    Fold Change: 3.26
    Marker Score: 1,475
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 3.25
    Marker Score: 6,331
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 3.24
    Marker Score: 2,343
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 3.24
    Marker Score: 2,760
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 3.21
    Marker Score: 1,605
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 3.19
    Marker Score: 1,377
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 3.18
    Marker Score: 1,110
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 3.13
    Marker Score: 5,305
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 3.13
    Marker Score: 1,802
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 3.12
    Marker Score: 2,073
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 3.1
    Marker Score: 1,296
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 3.09
    Marker Score: 1,016
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 3.07
    Marker Score: 1,848
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 3.07
    Marker Score: 6,007
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 3.05
    Marker Score: 2,041
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 3.05
    Marker Score: 2,533
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 3.05
    Marker Score: 1,722
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 3.04
    Marker Score: 2,014
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 3.03
    Marker Score: 1,777
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 3.03
    Marker Score: 3,033
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 3.03
    Marker Score: 7,306
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 3.02
    Marker Score: 3,337
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 3.02
    Marker Score: 1,067
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 3
    Marker Score: 3,538
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.98
    Marker Score: 4,879
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 2.97
    Marker Score: 788
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.96
    Marker Score: 1,231
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 2.94
    Marker Score: 911
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 2.93
    Marker Score: 1,784
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.91
    Marker Score: 1,736
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 2.91
    Marker Score: 6,543
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 2.9
    Marker Score: 3,008
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.88
    Marker Score: 18,432
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.87
    Marker Score: 5,007
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.87
    Marker Score: 29,087
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 2.87
    Marker Score: 753
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 2.85
    Marker Score: 993
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.85
    Marker Score: 680
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 2.81
    Marker Score: 713
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.79
    Marker Score: 2,200
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 2.78
    Marker Score: 1,733
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 2.74
    Marker Score: 6,827
  • Cell Name: Unknown (CL0000548)
    Fold Change: 2.74
    Marker Score: 1,997

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** HLA-E is a non-classical MHC class I molecule, distinct from the classical MHC class I molecules (e.g., HLA-A, HLA-B, and HLA-C). Unlike classical MHC class I molecules, which present exogenously synthesized peptides to CD8+ T cells, HLA-E presents endogenously synthesized peptides to NK cells and a subset of T cells, known as CD8+ alpha-beta T cells. This unique function of HLA-E is mediated by the binding of its alpha chain to the CD94/NKG2A inhibitory receptor on NK cells and the CD94/NKG2D activating receptor on a subset of T cells. **Pathways and Functions** HLA-E's primary function is to regulate immune responses by presenting endogenously synthesized peptides to NK cells and a subset of T cells. The binding of these peptides to the CD94/NKG2A receptor on NK cells inhibits their activation and cytotoxic activity, while the binding to the CD94/NKG2D receptor on T cells activates them, leading to their proliferation and cytotoxic activity. HLA-E also plays a role in regulating the activation and proliferation of T cells and the production of cytokines, such as IL-4 and IL-13. In addition to its role in regulating immune responses, HLA-E has been implicated in the regulation of various cellular processes, including: * Antigen presentation: HLA-E presents endogenously synthesized peptides to NK cells and a subset of T cells. * Cell surface expression: HLA-E is expressed on the surface of various cells, including immune cells, endothelial cells, and epithelial cells. * Cytokine signaling: HLA-E regulates the production of cytokines, such as IL-4 and IL-13. * Immune tolerance: HLA-E has been implicated in the regulation of immune tolerance, particularly in the context of NK cell tolerance. **Clinical Significance** HLA-E's role in regulating immune responses makes it an important gene in the context of immune-related disorders, such as: * Autoimmune diseases: Abnormalities in HLA-E expression and function may contribute to the development of autoimmune diseases, such as multiple sclerosis and type 1 diabetes. * Cancer: HLA-E's role in regulating immune responses may also contribute to the development and progression of cancer. * Infectious diseases: HLA-E's function in regulating immune responses may also be important in the context of infectious diseases, such as HIV and influenza. Furthermore, HLA-E has been implicated in the pathogenesis of various diseases, including: * COVID-19: HLA-E has been shown to be involved in the regulation of immune responses to SARS-CoV-2, the virus that causes COVID-19. * SARS-CoV-2-host interactions: HLA-E has been implicated in the regulation of immune responses to SARS-CoV-2, with implications for vaccine development and treatment. In conclusion, HLA-E is a critical gene in the regulation of immune responses, with implications for various diseases, including autoimmune diseases, cancer, and infectious diseases. Further research is needed to fully understand the role of HLA-E in the immune system and its clinical significance.

Genular Protein ID: 4026516970

Symbol: HLAE_HUMAN

Name: HLA class I histocompatibility antigen, alpha chain E

UniProtKB Accession Codes:

P13747 E2G051 Q30169 Q6DU44 Q9BT83 Q9GIY7 Q9GIY8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTC 1 CTD 1 ChEBI 16 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 35 EPD 1 Ensembl 7 EvolutionaryTrace 1 ExpressionAtlas 1 GO 48 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 31 PDBsum 26 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 9 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3131426

Title: Isolation and nucleotide sequence of a cDNA clone encoding a novel HLA class I gene.

PubMed ID: 3131426

PubMed ID: 10064069

Title: Cell surface expression of HLA-E: interaction with human beta-2 microglobulin and allelic differences.

PubMed ID: 10064069

DOI: 10.1002/(sici)1521-4141(199902)29:02<537::aid-immu537>3.0.co;2-6

PubMed ID: 3260916

Title: HLA-E. A novel HLA class I gene expressed in resting T lymphocytes.

PubMed ID: 3260916

PubMed ID: 1977695

Title: Polymorphism in the human class I MHC locus HLA-E in Japanese.

PubMed ID: 1977695

DOI: 10.1007/bf02114975

PubMed ID: 16702430

Title: Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity.

PubMed ID: 16702430

DOI: 10.1534/genetics.106.057034

PubMed ID: 16570139

Title: HLA-E, HLA-F, and HLA-G polymorphism: genomic sequence defines haplotype structure and variation spanning the nonclassical class I genes.

PubMed ID: 16570139

DOI: 10.1007/s00251-005-0076-z

PubMed ID: 28127896

Title: New insights in HLA-E polymorphism by refined analysis of the full-length gene.

PubMed ID: 28127896

DOI: 10.1111/tan.12965

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9427624

Title: TAP- and tapasin-dependent HLA-E surface expression correlates with the binding of an MHC class I leader peptide.

PubMed ID: 9427624

DOI: 10.1016/s0960-9822(98)70014-4

PubMed ID: 9754572

Title: HLA-E-bound peptides influence recognition by inhibitory and triggering CD94/NKG2 receptors: preferential response to an HLA-G-derived nonamer.

PubMed ID: 9754572

DOI: 10.1002/(sici)1521-4141(199809)28:09<2854::aid-immu2854>3.0.co;2-w

PubMed ID: 9486650

Title: HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C.

PubMed ID: 9486650

DOI: 10.1038/35869

PubMed ID: 10799855

Title: The human cytomegalovirus UL40 gene product contains a ligand for HLA-E and prevents NK cell-mediated lysis.

PubMed ID: 10799855

DOI: 10.4049/jimmunol.164.10.5019

PubMed ID: 12461076

Title: A signal peptide derived from hsp60 binds HLA-E and interferes with CD94/NKG2A recognition.

PubMed ID: 12461076

DOI: 10.1084/jem.20020797

PubMed ID: 15751767

Title: HIV-1 infection leads to increased HLA-E expression resulting in impaired function of natural killer cells.

PubMed ID: 15751767

DOI: 10.1177/135965350501000107

PubMed ID: 17179229

Title: Expression and release of soluble HLA-E is an immunoregulatory feature of endothelial cell activation.

PubMed ID: 17179229

DOI: 10.1182/blood-2006-06-030213

PubMed ID: 18083576

Title: The heterodimeric assembly of the CD94-NKG2 receptor family and implications for human leukocyte antigen-E recognition.

PubMed ID: 18083576

DOI: 10.1016/j.immuni.2007.10.013

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 20483783

Title: HLA-F complex without peptide binds to MHC class I protein in the open conformer form.

PubMed ID: 20483783

DOI: 10.4049/jimmunol.1000078

PubMed ID: 20195504

Title: Mycobacterium tuberculosis peptides presented by HLA-E molecules are targets for human CD8 T-cells with cytotoxic as well as regulatory activity.

PubMed ID: 20195504

DOI: 10.1371/journal.ppat.1000782

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23335510

Title: Polymorphism in human cytomegalovirus UL40 impacts on recognition of human leukocyte antigen-E (HLA-E) by natural killer cells.

PubMed ID: 23335510

DOI: 10.1074/jbc.m112.409672

PubMed ID: 30134159

Title: Distinct HLA-E Peptide Complexes Modify Antibody-Driven Effector Functions of Adaptive NK Cells.

PubMed ID: 30134159

DOI: 10.1016/j.celrep.2018.07.069

PubMed ID: 32859121

Title: SARS-CoV-2 Spike 1 Protein Controls Natural Killer Cell Activation via the HLA-E/NKG2A Pathway.

PubMed ID: 32859121

DOI: 10.3390/cells9091975

PubMed ID: 34228645

Title: HLA-E-restricted HIV-1-specific CD8+ T cell responses in natural infection.

PubMed ID: 34228645

DOI: 10.1172/jci148979

PubMed ID: 37264229

Title: HLA class I signal peptide polymorphism determines the level of CD94/NKG2-HLA-E-mediated regulation of effector cell responses.

PubMed ID: 37264229

DOI: 10.1038/s41590-023-01523-z

PubMed ID: 9660937

Title: Structural features impose tight peptide binding specificity in the nonclassical MHC molecule HLA-E.

PubMed ID: 9660937

DOI: 10.1016/s1097-2765(00)80053-2

PubMed ID: 16474394

Title: Structural basis for a major histocompatibility complex class Ib-restricted T cell response.

PubMed ID: 16474394

DOI: 10.1038/ni1312

PubMed ID: 18339401

Title: Subtle changes in peptide conformation profoundly affect recognition of the non-classical MHC class I molecule HLA-E by the CD94-NKG2 natural killer cell receptors.

PubMed ID: 18339401

DOI: 10.1016/j.jmb.2008.01.098

PubMed ID: 30087334

Title: Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding.

PubMed ID: 30087334

DOI: 10.1038/s41467-018-05459-z

PubMed ID: 35705051

Title: Primary and secondary functions of HLA-E are determined by stability and conformation of the peptide-bound complexes.

PubMed ID: 35705051

DOI: 10.1016/j.celrep.2022.110959

PubMed ID: 12445303

Title: Definitive high resolution typing of HLA-E allelic polymorphisms: identifying potential errors in existing allele data.

PubMed ID: 12445303

DOI: 10.1034/j.1399-0039.2002.600302.x

PubMed ID: 22665232

Title: Molecular typing of HLA-E.

PubMed ID: 22665232

DOI: 10.1007/978-1-61779-842-9_8

Sequence Information:

  • Length: 358
  • Mass: 40058
  • Checksum: 6B3001CA9F3B7FE3
  • Sequence:
    • MVDGTLLLLL SEALALTQTW AGSHSLKYFH TSVSRPGRGE PRFISVGYVD DTQFVRFDND 
AASPRMVPRA PWMEQEGSEY WDRETRSARD TAQIFRVNLR TLRGYYNQSE AGSHTLQWMH 
GCELGPDGRF LRGYEQFAYD GKDYLTLNED LRSWTAVDTA AQISEQKSND ASEAEHQRAY 
LEDTCVEWLH KYLEKGKETL LHLEPPKTHV THHPISDHEA TLRCWALGFY PAEITLTWQQ 
DGEGHTQDTE LVETRPAGDG TFQKWAAVVV PSGEEQRYTC HVQHEGLPEP VTLRWKPASQ 
PTIPIVGIIA GLVLLGSVVS GAVVAAVIWR KKSSGGKGGS YSKAEWSDSA QGSESHSL

Genular Protein ID: 2023731576

Symbol: O19682_HUMAN

Name: N/A

UniProtKB Accession Codes:

O19682

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 3 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 5 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIR 1 PROSITE 1 PeptideAtlas 1 Pfam 2 RefSeq 1 SAM 2 SMART 2 SUPFAM 1

Citations:

PubMed ID: 1530866

Title: Cloning and expression of a cDNA encoding a non-classical MHC class I antigen (HLA-E) in eosinophils from hypereosinophilic patients.

PubMed ID: 1530866

Sequence Information:

  • Length: 120
  • Mass: 12662
  • Checksum: D72D65787AB98847
  • Sequence:
    • QQDGEGHTQD TELVETRPAG DGTFQKWAAV VVPSGEEQRY TCHVQHEGLP EPVTLRWKPA 
SQPTIPIVGI IAGLVLLGSV VSGAVVAAVI WRKKSSGGKG GSYSKAEWSD SAQGSESHSL

Genular Protein ID: 295782492

Symbol: A8K8M6_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K8M6

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 9 Gene3D 2 Genevisible 1 GenomeRNAi 1 InterPro 10 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PeptideAtlas 1 Pfam 3 RefSeq 1 RuleBase 1 SAM 3 SMART 1 SUPFAM 2

Sequence Information:

  • Length: 358
  • Mass: 40102
  • Checksum: 82A7F8B82520C543
  • Sequence:
    • MVDGTLLLLL SEALALTQTW AGSHSLKYFH TSVSRPGRGE PRFISVGYVD DTQFVRFDND 
AASPRMVPRA PWMEQEGSEY WDRETRSARD TAQIFRVNLR TLRGYYNQSE AGSHTLQWMH 
GCELGPDGRF LRGYEQFAYD GKDYLTLNED LRSWTTVDTA AQISEQKSND ASEAEHQRAY 
LEDTCVEWLH KYLEKGKETL LHLEPPKTHV THHPISDHEA TLRCWALGFY PAEITLTWQQ 
DGEGHTQDTE LVETRPAGDG TFQKWAAVVV PSGEEQRYTC HVQHEGLPEP VTLRWKPASQ 
PTIPIVGIIA GLVLLGSLVS GAVVAAVIWR KKSSGGKGGS YSKAEWSDSA QGSESHSL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.