Details for: HLA E

Gene ID: 3133

Symbol: HLA E

Ensembl ID: ENSG00000204592

Description: major histocompatibility complex, class I, E

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 781.0590
    Cell Significance Index: -121.4900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 364.1333
    Cell Significance Index: -92.3600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 332.0568
    Cell Significance Index: -136.7900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 279.1277
    Cell Significance Index: -131.7800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 276.3590
    Cell Significance Index: -142.1600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 196.5881
    Cell Significance Index: -131.9200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 98.7221
    Cell Significance Index: -121.7200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 36.8946
    Cell Significance Index: -113.3200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 31.7938
    Cell Significance Index: -125.4600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 28.9365
    Cell Significance Index: -63.3300
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 23.6442
    Cell Significance Index: 63.3400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 14.9989
    Cell Significance Index: -40.1800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 13.9116
    Cell Significance Index: 245.8400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 9.7333
    Cell Significance Index: 110.5800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 9.6196
    Cell Significance Index: 177.8000
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 7.8029
    Cell Significance Index: 56.0400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 5.6373
    Cell Significance Index: 165.5600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 5.3590
    Cell Significance Index: 153.6200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 3.7147
    Cell Significance Index: 239.6600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 3.5708
    Cell Significance Index: 167.8300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 3.1023
    Cell Significance Index: 397.7000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.5845
    Cell Significance Index: 304.8000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.5048
    Cell Significance Index: 343.9800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.4669
    Cell Significance Index: 244.0300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.4658
    Cell Significance Index: 303.1900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 2.2974
    Cell Significance Index: 1015.7500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.9173
    Cell Significance Index: 247.7000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.8512
    Cell Significance Index: 333.7100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.8195
    Cell Significance Index: 49.5300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.7054
    Cell Significance Index: 120.6100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.6367
    Cell Significance Index: 178.0200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.5987
    Cell Significance Index: 119.1500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.3021
    Cell Significance Index: 711.1100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4135
    Cell Significance Index: 21.4800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.3708
    Cell Significance Index: 9.9200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3118
    Cell Significance Index: 8.9900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2160
    Cell Significance Index: 41.1000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2059
    Cell Significance Index: 40.8600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0553
    Cell Significance Index: 5.6500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0336
    Cell Significance Index: 5.7300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0286
    Cell Significance Index: 21.6800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0004
    Cell Significance Index: -0.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0516
    Cell Significance Index: -97.1700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0734
    Cell Significance Index: -54.3800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0779
    Cell Significance Index: -48.6700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0843
    Cell Significance Index: -155.4100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0989
    Cell Significance Index: -152.3200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.1068
    Cell Significance Index: -78.3000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.1197
    Cell Significance Index: -162.7500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1786
    Cell Significance Index: -100.7400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1917
    Cell Significance Index: -5.1200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1934
    Cell Significance Index: -122.8400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.2972
    Cell Significance Index: -134.8800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3398
    Cell Significance Index: -38.7900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.3494
    Cell Significance Index: -125.3100
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.3540
    Cell Significance Index: -5.0300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3734
    Cell Significance Index: -42.7800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3979
    Cell Significance Index: -83.8000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.4595
    Cell Significance Index: -23.2200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.4667
    Cell Significance Index: -134.2700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.6469
    Cell Significance Index: -129.7600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.7101
    Cell Significance Index: -103.2200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.8055
    Cell Significance Index: -33.0100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.8907
    Cell Significance Index: -103.8000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.9204
    Cell Significance Index: -29.4800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.0059
    Cell Significance Index: -17.3400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -1.0482
    Cell Significance Index: -47.5100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -1.0593
    Cell Significance Index: -6.4000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.1809
    Cell Significance Index: -29.5200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -1.1835
    Cell Significance Index: -81.8500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.2003
    Cell Significance Index: -124.9800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -1.5032
    Cell Significance Index: -42.0100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -1.6356
    Cell Significance Index: -41.7900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.6812
    Cell Significance Index: -129.0200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.7364
    Cell Significance Index: -137.5200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.8378
    Cell Significance Index: -39.1400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.9135
    Cell Significance Index: -41.4600
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -1.9384
    Cell Significance Index: -10.5700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -1.9854
    Cell Significance Index: -38.7500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -2.0063
    Cell Significance Index: -70.5000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -2.0258
    Cell Significance Index: -18.6600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -2.1146
    Cell Significance Index: -133.2800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -2.1814
    Cell Significance Index: -133.7400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -2.2052
    Cell Significance Index: -115.7800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -2.2134
    Cell Significance Index: -58.2000
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -2.2486
    Cell Significance Index: -32.3400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -2.2494
    Cell Significance Index: -30.6900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -2.3470
    Cell Significance Index: -131.7000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -2.3862
    Cell Significance Index: -55.1300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -3.0915
    Cell Significance Index: -47.8300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -3.1333
    Cell Significance Index: -115.0200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -3.2058
    Cell Significance Index: -141.8000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -3.2468
    Cell Significance Index: -48.6500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -3.3201
    Cell Significance Index: -55.5700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -3.3491
    Cell Significance Index: -116.3800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -3.3871
    Cell Significance Index: -99.7700
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -3.4769
    Cell Significance Index: -47.6100
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -3.5498
    Cell Significance Index: -72.2300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -3.6514
    Cell Significance Index: -76.4300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -3.6974
    Cell Significance Index: -140.0100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** HLA-E is a non-classical MHC class I molecule, distinct from the classical MHC class I molecules (e.g., HLA-A, HLA-B, and HLA-C). Unlike classical MHC class I molecules, which present exogenously synthesized peptides to CD8+ T cells, HLA-E presents endogenously synthesized peptides to NK cells and a subset of T cells, known as CD8+ alpha-beta T cells. This unique function of HLA-E is mediated by the binding of its alpha chain to the CD94/NKG2A inhibitory receptor on NK cells and the CD94/NKG2D activating receptor on a subset of T cells. **Pathways and Functions** HLA-E's primary function is to regulate immune responses by presenting endogenously synthesized peptides to NK cells and a subset of T cells. The binding of these peptides to the CD94/NKG2A receptor on NK cells inhibits their activation and cytotoxic activity, while the binding to the CD94/NKG2D receptor on T cells activates them, leading to their proliferation and cytotoxic activity. HLA-E also plays a role in regulating the activation and proliferation of T cells and the production of cytokines, such as IL-4 and IL-13. In addition to its role in regulating immune responses, HLA-E has been implicated in the regulation of various cellular processes, including: * Antigen presentation: HLA-E presents endogenously synthesized peptides to NK cells and a subset of T cells. * Cell surface expression: HLA-E is expressed on the surface of various cells, including immune cells, endothelial cells, and epithelial cells. * Cytokine signaling: HLA-E regulates the production of cytokines, such as IL-4 and IL-13. * Immune tolerance: HLA-E has been implicated in the regulation of immune tolerance, particularly in the context of NK cell tolerance. **Clinical Significance** HLA-E's role in regulating immune responses makes it an important gene in the context of immune-related disorders, such as: * Autoimmune diseases: Abnormalities in HLA-E expression and function may contribute to the development of autoimmune diseases, such as multiple sclerosis and type 1 diabetes. * Cancer: HLA-E's role in regulating immune responses may also contribute to the development and progression of cancer. * Infectious diseases: HLA-E's function in regulating immune responses may also be important in the context of infectious diseases, such as HIV and influenza. Furthermore, HLA-E has been implicated in the pathogenesis of various diseases, including: * COVID-19: HLA-E has been shown to be involved in the regulation of immune responses to SARS-CoV-2, the virus that causes COVID-19. * SARS-CoV-2-host interactions: HLA-E has been implicated in the regulation of immune responses to SARS-CoV-2, with implications for vaccine development and treatment. In conclusion, HLA-E is a critical gene in the regulation of immune responses, with implications for various diseases, including autoimmune diseases, cancer, and infectious diseases. Further research is needed to fully understand the role of HLA-E in the immune system and its clinical significance.

Genular Protein ID: 4026516970

Symbol: HLAE_HUMAN

Name: HLA class I histocompatibility antigen, alpha chain E

UniProtKB Accession Codes:

P13747 E2G051 Q30169 Q6DU44 Q9BT83 Q9GIY7 Q9GIY8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTC 1 CTD 1 ChEBI 16 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 35 Ensembl 7 EvolutionaryTrace 1 ExpressionAtlas 1 GO 48 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 27 PDBsum 27 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 9 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3131426

Title: Isolation and nucleotide sequence of a cDNA clone encoding a novel HLA class I gene.

PubMed ID: 3131426

PubMed ID: 10064069

Title: Cell surface expression of HLA-E: interaction with human beta-2 microglobulin and allelic differences.

PubMed ID: 10064069

DOI: 10.1002/(sici)1521-4141(199902)29:02<537::aid-immu537>3.0.co;2-6

PubMed ID: 3260916

Title: HLA-E. A novel HLA class I gene expressed in resting T lymphocytes.

PubMed ID: 3260916

PubMed ID: 1977695

Title: Polymorphism in the human class I MHC locus HLA-E in Japanese.

PubMed ID: 1977695

DOI: 10.1007/bf02114975

PubMed ID: 16702430

Title: Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity.

PubMed ID: 16702430

DOI: 10.1534/genetics.106.057034

PubMed ID: 16570139

Title: HLA-E, HLA-F, and HLA-G polymorphism: genomic sequence defines haplotype structure and variation spanning the nonclassical class I genes.

PubMed ID: 16570139

DOI: 10.1007/s00251-005-0076-z

PubMed ID: 28127896

Title: New insights in HLA-E polymorphism by refined analysis of the full-length gene.

PubMed ID: 28127896

DOI: 10.1111/tan.12965

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9427624

Title: TAP- and tapasin-dependent HLA-E surface expression correlates with the binding of an MHC class I leader peptide.

PubMed ID: 9427624

DOI: 10.1016/s0960-9822(98)70014-4

PubMed ID: 9754572

Title: HLA-E-bound peptides influence recognition by inhibitory and triggering CD94/NKG2 receptors: preferential response to an HLA-G-derived nonamer.

PubMed ID: 9754572

DOI: 10.1002/(sici)1521-4141(199809)28:09<2854::aid-immu2854>3.0.co;2-w

PubMed ID: 9486650

Title: HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C.

PubMed ID: 9486650

DOI: 10.1038/35869

PubMed ID: 10799855

Title: The human cytomegalovirus UL40 gene product contains a ligand for HLA-E and prevents NK cell-mediated lysis.

PubMed ID: 10799855

DOI: 10.4049/jimmunol.164.10.5019

PubMed ID: 12461076

Title: A signal peptide derived from hsp60 binds HLA-E and interferes with CD94/NKG2A recognition.

PubMed ID: 12461076

DOI: 10.1084/jem.20020797

PubMed ID: 15751767

Title: HIV-1 infection leads to increased HLA-E expression resulting in impaired function of natural killer cells.

PubMed ID: 15751767

DOI: 10.1177/135965350501000107

PubMed ID: 17179229

Title: Expression and release of soluble HLA-E is an immunoregulatory feature of endothelial cell activation.

PubMed ID: 17179229

DOI: 10.1182/blood-2006-06-030213

PubMed ID: 18083576

Title: The heterodimeric assembly of the CD94-NKG2 receptor family and implications for human leukocyte antigen-E recognition.

PubMed ID: 18083576

DOI: 10.1016/j.immuni.2007.10.013

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 20483783

Title: HLA-F complex without peptide binds to MHC class I protein in the open conformer form.

PubMed ID: 20483783

DOI: 10.4049/jimmunol.1000078

PubMed ID: 20195504

Title: Mycobacterium tuberculosis peptides presented by HLA-E molecules are targets for human CD8 T-cells with cytotoxic as well as regulatory activity.

PubMed ID: 20195504

DOI: 10.1371/journal.ppat.1000782

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23335510

Title: Polymorphism in human cytomegalovirus UL40 impacts on recognition of human leukocyte antigen-E (HLA-E) by natural killer cells.

PubMed ID: 23335510

DOI: 10.1074/jbc.m112.409672

PubMed ID: 30134159

Title: Distinct HLA-E Peptide Complexes Modify Antibody-Driven Effector Functions of Adaptive NK Cells.

PubMed ID: 30134159

DOI: 10.1016/j.celrep.2018.07.069

PubMed ID: 32859121

Title: SARS-CoV-2 Spike 1 Protein Controls Natural Killer Cell Activation via the HLA-E/NKG2A Pathway.

PubMed ID: 32859121

DOI: 10.3390/cells9091975

PubMed ID: 34228645

Title: HLA-E-restricted HIV-1-specific CD8+ T cell responses in natural infection.

PubMed ID: 34228645

DOI: 10.1172/jci148979

PubMed ID: 37264229

Title: HLA class I signal peptide polymorphism determines the level of CD94/NKG2-HLA-E-mediated regulation of effector cell responses.

PubMed ID: 37264229

DOI: 10.1038/s41590-023-01523-z

PubMed ID: 9660937

Title: Structural features impose tight peptide binding specificity in the nonclassical MHC molecule HLA-E.

PubMed ID: 9660937

DOI: 10.1016/s1097-2765(00)80053-2

PubMed ID: 16474394

Title: Structural basis for a major histocompatibility complex class Ib-restricted T cell response.

PubMed ID: 16474394

DOI: 10.1038/ni1312

PubMed ID: 18339401

Title: Subtle changes in peptide conformation profoundly affect recognition of the non-classical MHC class I molecule HLA-E by the CD94-NKG2 natural killer cell receptors.

PubMed ID: 18339401

DOI: 10.1016/j.jmb.2008.01.098

PubMed ID: 30087334

Title: Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding.

PubMed ID: 30087334

DOI: 10.1038/s41467-018-05459-z

PubMed ID: 35705051

Title: Primary and secondary functions of HLA-E are determined by stability and conformation of the peptide-bound complexes.

PubMed ID: 35705051

DOI: 10.1016/j.celrep.2022.110959

PubMed ID: 12445303

Title: Definitive high resolution typing of HLA-E allelic polymorphisms: identifying potential errors in existing allele data.

PubMed ID: 12445303

DOI: 10.1034/j.1399-0039.2002.600302.x

PubMed ID: 22665232

Title: Molecular typing of HLA-E.

PubMed ID: 22665232

DOI: 10.1007/978-1-61779-842-9_8

Sequence Information:

  • Length: 358
  • Mass: 40058
  • Checksum: 6B3001CA9F3B7FE3
  • Sequence:
    • MVDGTLLLLL SEALALTQTW AGSHSLKYFH TSVSRPGRGE PRFISVGYVD DTQFVRFDND 
AASPRMVPRA PWMEQEGSEY WDRETRSARD TAQIFRVNLR TLRGYYNQSE AGSHTLQWMH 
GCELGPDGRF LRGYEQFAYD GKDYLTLNED LRSWTAVDTA AQISEQKSND ASEAEHQRAY 
LEDTCVEWLH KYLEKGKETL LHLEPPKTHV THHPISDHEA TLRCWALGFY PAEITLTWQQ 
DGEGHTQDTE LVETRPAGDG TFQKWAAVVV PSGEEQRYTC HVQHEGLPEP VTLRWKPASQ 
PTIPIVGIIA GLVLLGSVVS GAVVAAVIWR KKSSGGKGGS YSKAEWSDSA QGSESHSL

Genular Protein ID: 2023731576

Symbol: O19682_HUMAN

Name: N/A

UniProtKB Accession Codes:

O19682

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 8 Gene3D 1 InterPro 6 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIR 1 PROSITE 1 PeptideAtlas 1 Pfam 2 RefSeq 1 SAM 2 SMART 2 SUPFAM 1

Citations:

PubMed ID: 1530866

Title: Cloning and expression of a cDNA encoding a non-classical MHC class I antigen (HLA-E) in eosinophils from hypereosinophilic patients.

PubMed ID: 1530866

Sequence Information:

  • Length: 120
  • Mass: 12662
  • Checksum: D72D65787AB98847
  • Sequence:
    • QQDGEGHTQD TELVETRPAG DGTFQKWAAV VVPSGEEQRY TCHVQHEGLP EPVTLRWKPA 
SQPTIPIVGI IAGLVLLGSV VSGAVVAAVI WRKKSSGGKG GSYSKAEWSD SAQGSESHSL

Genular Protein ID: 295782492

Symbol: A8K8M6_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K8M6

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 8 Gene3D 2 InterPro 11 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 Pfam 3 RefSeq 1 RuleBase 1 SAM 3 SMART 1 SUPFAM 2

Sequence Information:

  • Length: 358
  • Mass: 40102
  • Checksum: 82A7F8B82520C543
  • Sequence:
    • MVDGTLLLLL SEALALTQTW AGSHSLKYFH TSVSRPGRGE PRFISVGYVD DTQFVRFDND 
AASPRMVPRA PWMEQEGSEY WDRETRSARD TAQIFRVNLR TLRGYYNQSE AGSHTLQWMH 
GCELGPDGRF LRGYEQFAYD GKDYLTLNED LRSWTTVDTA AQISEQKSND ASEAEHQRAY 
LEDTCVEWLH KYLEKGKETL LHLEPPKTHV THHPISDHEA TLRCWALGFY PAEITLTWQQ 
DGEGHTQDTE LVETRPAGDG TFQKWAAVVV PSGEEQRYTC HVQHEGLPEP VTLRWKPASQ 
PTIPIVGIIA GLVLLGSLVS GAVVAAVIWR KKSSGGKGGS YSKAEWSDSA QGSESHSL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.