Details for: HLA E
Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: 5.89
Marker Score: 14,963 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 5.27
Marker Score: 3,721 - Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 5.24
Marker Score: 15,280 - Cell Name: mature T cell (CL0002419)
Fold Change: 5.2
Marker Score: 51,496 - Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 4.94
Marker Score: 4,196 - Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 4.88
Marker Score: 15,409 - Cell Name: classical monocyte (CL0000860)
Fold Change: 4.77
Marker Score: 19,817 - Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 4.66
Marker Score: 246,419 - Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
Fold Change: 4.64
Marker Score: 6,715 - Cell Name: naive T cell (CL0000898)
Fold Change: 4.61
Marker Score: 2,972 - Cell Name: myeloid dendritic cell (CL0000782)
Fold Change: 4.33
Marker Score: 2,626 - Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 4.29
Marker Score: 12,021 - Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: 4.26
Marker Score: 7,305 - Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 4.23
Marker Score: 4,092 - Cell Name: CD38-negative naive B cell (CL0002102)
Fold Change: 4.23
Marker Score: 8,873 - Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: 4.22
Marker Score: 3,063 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 4.2
Marker Score: 234,638 - Cell Name: blood cell (CL0000081)
Fold Change: 4.18
Marker Score: 48,589 - Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 4.16
Marker Score: 11,495 - Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: 4.09
Marker Score: 3,523 - Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 4.08
Marker Score: 17,497 - Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: 4.08
Marker Score: 9,948 - Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 4.02
Marker Score: 5,927 - Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 3.96
Marker Score: 3,905 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 3.93
Marker Score: 133,552 - Cell Name: natural T-regulatory cell (CL0000903)
Fold Change: 3.93
Marker Score: 2,017 - Cell Name: intraepithelial lymphocyte (CL0002496)
Fold Change: 3.92
Marker Score: 4,360 - Cell Name: naive B cell (CL0000788)
Fold Change: 3.86
Marker Score: 3,444 - Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
Fold Change: 3.82
Marker Score: 1,242 - Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 3.79
Marker Score: 3,368 - Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 3.77
Marker Score: 3,171 - Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 3.71
Marker Score: 2,281 - Cell Name: neutrophil (CL0000775)
Fold Change: 3.69
Marker Score: 2,247 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: 3.68
Marker Score: 3,598 - Cell Name: class switched memory B cell (CL0000972)
Fold Change: 3.67
Marker Score: 3,451 - Cell Name: tracheobronchial smooth muscle cell (CL0019019)
Fold Change: 3.66
Marker Score: 1,074 - Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: 3.59
Marker Score: 6,409 - Cell Name: type I NK T cell (CL0000921)
Fold Change: 3.57
Marker Score: 2,805 - Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 3.56
Marker Score: 2,428 - Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: 3.56
Marker Score: 3,128 - Cell Name: memory T cell (CL0000813)
Fold Change: 3.55
Marker Score: 1,527 - Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 3.54
Marker Score: 3,163 - Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 3.53
Marker Score: 3,012 - Cell Name: alpha-beta T cell (CL0000789)
Fold Change: 3.52
Marker Score: 2,667 - Cell Name: double negative thymocyte (CL0002489)
Fold Change: 3.44
Marker Score: 4,751 - Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 3.41
Marker Score: 3,644 - Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: 3.39
Marker Score: 2,485 - Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: 3.31
Marker Score: 1,848 - Cell Name: peritubular capillary endothelial cell (CL1001033)
Fold Change: 3.3
Marker Score: 768 - Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
Fold Change: 3.3
Marker Score: 3,090 - Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 3.3
Marker Score: 3,551 - Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 3.3
Marker Score: 6,590 - Cell Name: malignant cell (CL0001064)
Fold Change: 3.29
Marker Score: 44,230 - Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 3.28
Marker Score: 2,687 - Cell Name: memory B cell (CL0000787)
Fold Change: 3.27
Marker Score: 2,474 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 3.26
Marker Score: 7,972 - Cell Name: lung macrophage (CL1001603)
Fold Change: 3.26
Marker Score: 3,734 - Cell Name: platelet (CL0000233)
Fold Change: 3.26
Marker Score: 1,475 - Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 3.25
Marker Score: 6,331 - Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
Fold Change: 3.24
Marker Score: 2,343 - Cell Name: IgA plasma cell (CL0000987)
Fold Change: 3.24
Marker Score: 2,760 - Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 3.21
Marker Score: 1,605 - Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 3.19
Marker Score: 1,377 - Cell Name: memory regulatory T cell (CL0002678)
Fold Change: 3.18
Marker Score: 1,110 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 3.13
Marker Score: 5,305 - Cell Name: exhausted T cell (CL0011025)
Fold Change: 3.13
Marker Score: 1,802 - Cell Name: hematopoietic cell (CL0000988)
Fold Change: 3.12
Marker Score: 2,073 - Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 3.1
Marker Score: 1,296 - Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
Fold Change: 3.09
Marker Score: 1,016 - Cell Name: IgG memory B cell (CL0000979)
Fold Change: 3.07
Marker Score: 1,848 - Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: 3.07
Marker Score: 6,007 - Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 3.05
Marker Score: 2,041 - Cell Name: T follicular helper cell (CL0002038)
Fold Change: 3.05
Marker Score: 2,533 - Cell Name: endocardial cell (CL0002350)
Fold Change: 3.05
Marker Score: 1,722 - Cell Name: immature B cell (CL0000816)
Fold Change: 3.04
Marker Score: 2,014 - Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 3.03
Marker Score: 1,777 - Cell Name: Kupffer cell (CL0000091)
Fold Change: 3.03
Marker Score: 3,033 - Cell Name: non-classical monocyte (CL0000875)
Fold Change: 3.03
Marker Score: 7,306 - Cell Name: regulatory T cell (CL0000815)
Fold Change: 3.02
Marker Score: 3,337 - Cell Name: transitional stage B cell (CL0000818)
Fold Change: 3.02
Marker Score: 1,067 - Cell Name: late pro-B cell (CL0002048)
Fold Change: 3
Marker Score: 3,538 - Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 2.98
Marker Score: 4,879 - Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
Fold Change: 2.97
Marker Score: 788 - Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 2.96
Marker Score: 1,231 - Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 2.94
Marker Score: 911 - Cell Name: germinal center B cell (CL0000844)
Fold Change: 2.93
Marker Score: 1,784 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 2.91
Marker Score: 1,736 - Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
Fold Change: 2.91
Marker Score: 6,543 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 2.9
Marker Score: 3,008 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 2.88
Marker Score: 18,432 - Cell Name: B-1 B cell (CL0000819)
Fold Change: 2.87
Marker Score: 5,007 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 2.87
Marker Score: 29,087 - Cell Name: IgA plasmablast (CL0000984)
Fold Change: 2.87
Marker Score: 753 - Cell Name: IgM plasma cell (CL0000986)
Fold Change: 2.85
Marker Score: 993 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 2.85
Marker Score: 680 - Cell Name: ILC1, human (CL0001077)
Fold Change: 2.81
Marker Score: 713 - Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 2.79
Marker Score: 2,200 - Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: 2.78
Marker Score: 1,733 - Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 2.74
Marker Score: 6,827 - Cell Name: Unknown (CL0000548)
Fold Change: 2.74
Marker Score: 1,997
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 4026516970
Symbol: HLAE_HUMAN
Name: HLA class I histocompatibility antigen, alpha chain E
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 3131426
Title: Isolation and nucleotide sequence of a cDNA clone encoding a novel HLA class I gene.
PubMed ID: 3131426
PubMed ID: 10064069
Title: Cell surface expression of HLA-E: interaction with human beta-2 microglobulin and allelic differences.
PubMed ID: 10064069
DOI: 10.1002/(sici)1521-4141(199902)29:02<537::aid-immu537>3.0.co;2-6
PubMed ID: 3260916
Title: HLA-E. A novel HLA class I gene expressed in resting T lymphocytes.
PubMed ID: 3260916
PubMed ID: 1977695
Title: Polymorphism in the human class I MHC locus HLA-E in Japanese.
PubMed ID: 1977695
DOI: 10.1007/bf02114975
PubMed ID: 16702430
Title: Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity.
PubMed ID: 16702430
PubMed ID: 16570139
Title: HLA-E, HLA-F, and HLA-G polymorphism: genomic sequence defines haplotype structure and variation spanning the nonclassical class I genes.
PubMed ID: 16570139
PubMed ID: 28127896
Title: New insights in HLA-E polymorphism by refined analysis of the full-length gene.
PubMed ID: 28127896
DOI: 10.1111/tan.12965
PubMed ID: 14574404
Title: The DNA sequence and analysis of human chromosome 6.
PubMed ID: 14574404
DOI: 10.1038/nature02055
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9427624
Title: TAP- and tapasin-dependent HLA-E surface expression correlates with the binding of an MHC class I leader peptide.
PubMed ID: 9427624
PubMed ID: 9754572
Title: HLA-E-bound peptides influence recognition by inhibitory and triggering CD94/NKG2 receptors: preferential response to an HLA-G-derived nonamer.
PubMed ID: 9754572
DOI: 10.1002/(sici)1521-4141(199809)28:09<2854::aid-immu2854>3.0.co;2-w
PubMed ID: 9486650
Title: HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C.
PubMed ID: 9486650
DOI: 10.1038/35869
PubMed ID: 10799855
Title: The human cytomegalovirus UL40 gene product contains a ligand for HLA-E and prevents NK cell-mediated lysis.
PubMed ID: 10799855
PubMed ID: 12461076
Title: A signal peptide derived from hsp60 binds HLA-E and interferes with CD94/NKG2A recognition.
PubMed ID: 12461076
DOI: 10.1084/jem.20020797
PubMed ID: 15751767
Title: HIV-1 infection leads to increased HLA-E expression resulting in impaired function of natural killer cells.
PubMed ID: 15751767
PubMed ID: 17179229
Title: Expression and release of soluble HLA-E is an immunoregulatory feature of endothelial cell activation.
PubMed ID: 17179229
PubMed ID: 18083576
Title: The heterodimeric assembly of the CD94-NKG2 receptor family and implications for human leukocyte antigen-E recognition.
PubMed ID: 18083576
PubMed ID: 19349973
Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.
PubMed ID: 19349973
DOI: 10.1038/nbt.1532
PubMed ID: 20483783
Title: HLA-F complex without peptide binds to MHC class I protein in the open conformer form.
PubMed ID: 20483783
PubMed ID: 20195504
Title: Mycobacterium tuberculosis peptides presented by HLA-E molecules are targets for human CD8 T-cells with cytotoxic as well as regulatory activity.
PubMed ID: 20195504
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23335510
Title: Polymorphism in human cytomegalovirus UL40 impacts on recognition of human leukocyte antigen-E (HLA-E) by natural killer cells.
PubMed ID: 23335510
PubMed ID: 30134159
Title: Distinct HLA-E Peptide Complexes Modify Antibody-Driven Effector Functions of Adaptive NK Cells.
PubMed ID: 30134159
PubMed ID: 32859121
Title: SARS-CoV-2 Spike 1 Protein Controls Natural Killer Cell Activation via the HLA-E/NKG2A Pathway.
PubMed ID: 32859121
DOI: 10.3390/cells9091975
PubMed ID: 34228645
Title: HLA-E-restricted HIV-1-specific CD8+ T cell responses in natural infection.
PubMed ID: 34228645
DOI: 10.1172/jci148979
PubMed ID: 37264229
Title: HLA class I signal peptide polymorphism determines the level of CD94/NKG2-HLA-E-mediated regulation of effector cell responses.
PubMed ID: 37264229
PubMed ID: 9660937
Title: Structural features impose tight peptide binding specificity in the nonclassical MHC molecule HLA-E.
PubMed ID: 9660937
PubMed ID: 16474394
Title: Structural basis for a major histocompatibility complex class Ib-restricted T cell response.
PubMed ID: 16474394
DOI: 10.1038/ni1312
PubMed ID: 18339401
Title: Subtle changes in peptide conformation profoundly affect recognition of the non-classical MHC class I molecule HLA-E by the CD94-NKG2 natural killer cell receptors.
PubMed ID: 18339401
PubMed ID: 30087334
Title: Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding.
PubMed ID: 30087334
PubMed ID: 35705051
Title: Primary and secondary functions of HLA-E are determined by stability and conformation of the peptide-bound complexes.
PubMed ID: 35705051
PubMed ID: 12445303
Title: Definitive high resolution typing of HLA-E allelic polymorphisms: identifying potential errors in existing allele data.
PubMed ID: 12445303
PubMed ID: 22665232
Sequence Information:
- Length: 358
- Mass: 40058
- Checksum: 6B3001CA9F3B7FE3
- Sequence:
MVDGTLLLLL SEALALTQTW AGSHSLKYFH TSVSRPGRGE PRFISVGYVD DTQFVRFDND AASPRMVPRA PWMEQEGSEY WDRETRSARD TAQIFRVNLR TLRGYYNQSE AGSHTLQWMH GCELGPDGRF LRGYEQFAYD GKDYLTLNED LRSWTAVDTA AQISEQKSND ASEAEHQRAY LEDTCVEWLH KYLEKGKETL LHLEPPKTHV THHPISDHEA TLRCWALGFY PAEITLTWQQ DGEGHTQDTE LVETRPAGDG TFQKWAAVVV PSGEEQRYTC HVQHEGLPEP VTLRWKPASQ PTIPIVGIIA GLVLLGSVVS GAVVAAVIWR KKSSGGKGGS YSKAEWSDSA QGSESHSL
Genular Protein ID: 2023731576
Symbol: O19682_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1530866
Title: Cloning and expression of a cDNA encoding a non-classical MHC class I antigen (HLA-E) in eosinophils from hypereosinophilic patients.
PubMed ID: 1530866
Sequence Information:
- Length: 120
- Mass: 12662
- Checksum: D72D65787AB98847
- Sequence:
QQDGEGHTQD TELVETRPAG DGTFQKWAAV VVPSGEEQRY TCHVQHEGLP EPVTLRWKPA SQPTIPIVGI IAGLVLLGSV VSGAVVAAVI WRKKSSGGKG GSYSKAEWSD SAQGSESHSL
Genular Protein ID: 295782492
Symbol: A8K8M6_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 358
- Mass: 40102
- Checksum: 82A7F8B82520C543
- Sequence:
MVDGTLLLLL SEALALTQTW AGSHSLKYFH TSVSRPGRGE PRFISVGYVD DTQFVRFDND AASPRMVPRA PWMEQEGSEY WDRETRSARD TAQIFRVNLR TLRGYYNQSE AGSHTLQWMH GCELGPDGRF LRGYEQFAYD GKDYLTLNED LRSWTTVDTA AQISEQKSND ASEAEHQRAY LEDTCVEWLH KYLEKGKETL LHLEPPKTHV THHPISDHEA TLRCWALGFY PAEITLTWQQ DGEGHTQDTE LVETRPAGDG TFQKWAAVVV PSGEEQRYTC HVQHEGLPEP VTLRWKPASQ PTIPIVGIIA GLVLLGSLVS GAVVAAVIWR KKSSGGKGGS YSKAEWSDSA QGSESHSL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.