Details for: HLA E
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 781.0590
Cell Significance Index: -121.4900 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 364.1333
Cell Significance Index: -92.3600 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 332.0568
Cell Significance Index: -136.7900 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 279.1277
Cell Significance Index: -131.7800 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 276.3590
Cell Significance Index: -142.1600 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 196.5881
Cell Significance Index: -131.9200 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 98.7221
Cell Significance Index: -121.7200 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 36.8946
Cell Significance Index: -113.3200 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 31.7938
Cell Significance Index: -125.4600 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 28.9365
Cell Significance Index: -63.3300 - Cell Name: hepatic pit cell (CL2000054)
Fold Change: 23.6442
Cell Significance Index: 63.3400 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 14.9989
Cell Significance Index: -40.1800 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 13.9116
Cell Significance Index: 245.8400 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 9.7333
Cell Significance Index: 110.5800 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 9.6196
Cell Significance Index: 177.8000 - Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 7.8029
Cell Significance Index: 56.0400 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 5.6373
Cell Significance Index: 165.5600 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 5.3590
Cell Significance Index: 153.6200 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 3.7147
Cell Significance Index: 239.6600 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 3.5708
Cell Significance Index: 167.8300 - Cell Name: odontoblast (CL0000060)
Fold Change: 3.1023
Cell Significance Index: 397.7000 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 2.5845
Cell Significance Index: 304.8000 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 2.5048
Cell Significance Index: 343.9800 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 2.4669
Cell Significance Index: 244.0300 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 2.4658
Cell Significance Index: 303.1900 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 2.2974
Cell Significance Index: 1015.7500 - Cell Name: lactocyte (CL0002325)
Fold Change: 1.9173
Cell Significance Index: 247.7000 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.8512
Cell Significance Index: 333.7100 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.8195
Cell Significance Index: 49.5300 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 1.7054
Cell Significance Index: 120.6100 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.6367
Cell Significance Index: 178.0200 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.5987
Cell Significance Index: 119.1500 - Cell Name: cell in vitro (CL0001034)
Fold Change: 1.3021
Cell Significance Index: 711.1100 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.4135
Cell Significance Index: 21.4800 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.3708
Cell Significance Index: 9.9200 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.3118
Cell Significance Index: 8.9900 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2160
Cell Significance Index: 41.1000 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.2059
Cell Significance Index: 40.8600 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.0553
Cell Significance Index: 5.6500 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0336
Cell Significance Index: 5.7300 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0286
Cell Significance Index: 21.6800 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0004
Cell Significance Index: -0.0200 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0516
Cell Significance Index: -97.1700 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0734
Cell Significance Index: -54.3800 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0779
Cell Significance Index: -48.6700 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0843
Cell Significance Index: -155.4100 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0989
Cell Significance Index: -152.3200 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.1068
Cell Significance Index: -78.3000 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.1197
Cell Significance Index: -162.7500 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1786
Cell Significance Index: -100.7400 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.1917
Cell Significance Index: -5.1200 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.1934
Cell Significance Index: -122.8400 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.2972
Cell Significance Index: -134.8800 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.3398
Cell Significance Index: -38.7900 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.3494
Cell Significance Index: -125.3100 - Cell Name: helper T cell (CL0000912)
Fold Change: -0.3540
Cell Significance Index: -5.0300 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.3734
Cell Significance Index: -42.7800 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.3979
Cell Significance Index: -83.8000 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.4595
Cell Significance Index: -23.2200 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.4667
Cell Significance Index: -134.2700 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.6469
Cell Significance Index: -129.7600 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.7101
Cell Significance Index: -103.2200 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.8055
Cell Significance Index: -33.0100 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.8907
Cell Significance Index: -103.8000 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.9204
Cell Significance Index: -29.4800 - Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -1.0059
Cell Significance Index: -17.3400 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -1.0482
Cell Significance Index: -47.5100 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -1.0593
Cell Significance Index: -6.4000 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -1.1809
Cell Significance Index: -29.5200 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -1.1835
Cell Significance Index: -81.8500 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -1.2003
Cell Significance Index: -124.9800 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -1.5032
Cell Significance Index: -42.0100 - Cell Name: pro-T cell (CL0000827)
Fold Change: -1.6356
Cell Significance Index: -41.7900 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -1.6812
Cell Significance Index: -129.0200 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -1.7364
Cell Significance Index: -137.5200 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -1.8378
Cell Significance Index: -39.1400 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -1.9135
Cell Significance Index: -41.4600 - Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: -1.9384
Cell Significance Index: -10.5700 - Cell Name: preadipocyte (CL0002334)
Fold Change: -1.9854
Cell Significance Index: -38.7500 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -2.0063
Cell Significance Index: -70.5000 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -2.0258
Cell Significance Index: -18.6600 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -2.1146
Cell Significance Index: -133.2800 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -2.1814
Cell Significance Index: -133.7400 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -2.2052
Cell Significance Index: -115.7800 - Cell Name: granulosa cell (CL0000501)
Fold Change: -2.2134
Cell Significance Index: -58.2000 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: -2.2486
Cell Significance Index: -32.3400 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -2.2494
Cell Significance Index: -30.6900 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -2.3470
Cell Significance Index: -131.7000 - Cell Name: peg cell (CL4033014)
Fold Change: -2.3862
Cell Significance Index: -55.1300 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: -3.0915
Cell Significance Index: -47.8300 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -3.1333
Cell Significance Index: -115.0200 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -3.2058
Cell Significance Index: -141.8000 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -3.2468
Cell Significance Index: -48.6500 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -3.3201
Cell Significance Index: -55.5700 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -3.3491
Cell Significance Index: -116.3800 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -3.3871
Cell Significance Index: -99.7700 - Cell Name: pulmonary capillary endothelial cell (CL4028001)
Fold Change: -3.4769
Cell Significance Index: -47.6100 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: -3.5498
Cell Significance Index: -72.2300 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -3.6514
Cell Significance Index: -76.4300 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -3.6974
Cell Significance Index: -140.0100
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 4026516970
Symbol: HLAE_HUMAN
Name: HLA class I histocompatibility antigen, alpha chain E
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 3131426
Title: Isolation and nucleotide sequence of a cDNA clone encoding a novel HLA class I gene.
PubMed ID: 3131426
PubMed ID: 10064069
Title: Cell surface expression of HLA-E: interaction with human beta-2 microglobulin and allelic differences.
PubMed ID: 10064069
DOI: 10.1002/(sici)1521-4141(199902)29:02<537::aid-immu537>3.0.co;2-6
PubMed ID: 3260916
Title: HLA-E. A novel HLA class I gene expressed in resting T lymphocytes.
PubMed ID: 3260916
PubMed ID: 1977695
Title: Polymorphism in the human class I MHC locus HLA-E in Japanese.
PubMed ID: 1977695
DOI: 10.1007/bf02114975
PubMed ID: 16702430
Title: Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity.
PubMed ID: 16702430
PubMed ID: 16570139
Title: HLA-E, HLA-F, and HLA-G polymorphism: genomic sequence defines haplotype structure and variation spanning the nonclassical class I genes.
PubMed ID: 16570139
PubMed ID: 28127896
Title: New insights in HLA-E polymorphism by refined analysis of the full-length gene.
PubMed ID: 28127896
DOI: 10.1111/tan.12965
PubMed ID: 14574404
Title: The DNA sequence and analysis of human chromosome 6.
PubMed ID: 14574404
DOI: 10.1038/nature02055
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9427624
Title: TAP- and tapasin-dependent HLA-E surface expression correlates with the binding of an MHC class I leader peptide.
PubMed ID: 9427624
PubMed ID: 9754572
Title: HLA-E-bound peptides influence recognition by inhibitory and triggering CD94/NKG2 receptors: preferential response to an HLA-G-derived nonamer.
PubMed ID: 9754572
DOI: 10.1002/(sici)1521-4141(199809)28:09<2854::aid-immu2854>3.0.co;2-w
PubMed ID: 9486650
Title: HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C.
PubMed ID: 9486650
DOI: 10.1038/35869
PubMed ID: 10799855
Title: The human cytomegalovirus UL40 gene product contains a ligand for HLA-E and prevents NK cell-mediated lysis.
PubMed ID: 10799855
PubMed ID: 12461076
Title: A signal peptide derived from hsp60 binds HLA-E and interferes with CD94/NKG2A recognition.
PubMed ID: 12461076
DOI: 10.1084/jem.20020797
PubMed ID: 15751767
Title: HIV-1 infection leads to increased HLA-E expression resulting in impaired function of natural killer cells.
PubMed ID: 15751767
PubMed ID: 17179229
Title: Expression and release of soluble HLA-E is an immunoregulatory feature of endothelial cell activation.
PubMed ID: 17179229
PubMed ID: 18083576
Title: The heterodimeric assembly of the CD94-NKG2 receptor family and implications for human leukocyte antigen-E recognition.
PubMed ID: 18083576
PubMed ID: 19349973
Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.
PubMed ID: 19349973
DOI: 10.1038/nbt.1532
PubMed ID: 20483783
Title: HLA-F complex without peptide binds to MHC class I protein in the open conformer form.
PubMed ID: 20483783
PubMed ID: 20195504
Title: Mycobacterium tuberculosis peptides presented by HLA-E molecules are targets for human CD8 T-cells with cytotoxic as well as regulatory activity.
PubMed ID: 20195504
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23335510
Title: Polymorphism in human cytomegalovirus UL40 impacts on recognition of human leukocyte antigen-E (HLA-E) by natural killer cells.
PubMed ID: 23335510
PubMed ID: 30134159
Title: Distinct HLA-E Peptide Complexes Modify Antibody-Driven Effector Functions of Adaptive NK Cells.
PubMed ID: 30134159
PubMed ID: 32859121
Title: SARS-CoV-2 Spike 1 Protein Controls Natural Killer Cell Activation via the HLA-E/NKG2A Pathway.
PubMed ID: 32859121
DOI: 10.3390/cells9091975
PubMed ID: 34228645
Title: HLA-E-restricted HIV-1-specific CD8+ T cell responses in natural infection.
PubMed ID: 34228645
DOI: 10.1172/jci148979
PubMed ID: 37264229
Title: HLA class I signal peptide polymorphism determines the level of CD94/NKG2-HLA-E-mediated regulation of effector cell responses.
PubMed ID: 37264229
PubMed ID: 9660937
Title: Structural features impose tight peptide binding specificity in the nonclassical MHC molecule HLA-E.
PubMed ID: 9660937
PubMed ID: 16474394
Title: Structural basis for a major histocompatibility complex class Ib-restricted T cell response.
PubMed ID: 16474394
DOI: 10.1038/ni1312
PubMed ID: 18339401
Title: Subtle changes in peptide conformation profoundly affect recognition of the non-classical MHC class I molecule HLA-E by the CD94-NKG2 natural killer cell receptors.
PubMed ID: 18339401
PubMed ID: 30087334
Title: Pathogen-derived HLA-E bound epitopes reveal broad primary anchor pocket tolerability and conformationally malleable peptide binding.
PubMed ID: 30087334
PubMed ID: 35705051
Title: Primary and secondary functions of HLA-E are determined by stability and conformation of the peptide-bound complexes.
PubMed ID: 35705051
PubMed ID: 12445303
Title: Definitive high resolution typing of HLA-E allelic polymorphisms: identifying potential errors in existing allele data.
PubMed ID: 12445303
PubMed ID: 22665232
Sequence Information:
- Length: 358
- Mass: 40058
- Checksum: 6B3001CA9F3B7FE3
- Sequence:
MVDGTLLLLL SEALALTQTW AGSHSLKYFH TSVSRPGRGE PRFISVGYVD DTQFVRFDND AASPRMVPRA PWMEQEGSEY WDRETRSARD TAQIFRVNLR TLRGYYNQSE AGSHTLQWMH GCELGPDGRF LRGYEQFAYD GKDYLTLNED LRSWTAVDTA AQISEQKSND ASEAEHQRAY LEDTCVEWLH KYLEKGKETL LHLEPPKTHV THHPISDHEA TLRCWALGFY PAEITLTWQQ DGEGHTQDTE LVETRPAGDG TFQKWAAVVV PSGEEQRYTC HVQHEGLPEP VTLRWKPASQ PTIPIVGIIA GLVLLGSVVS GAVVAAVIWR KKSSGGKGGS YSKAEWSDSA QGSESHSL
Genular Protein ID: 2023731576
Symbol: O19682_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1530866
Title: Cloning and expression of a cDNA encoding a non-classical MHC class I antigen (HLA-E) in eosinophils from hypereosinophilic patients.
PubMed ID: 1530866
Sequence Information:
- Length: 120
- Mass: 12662
- Checksum: D72D65787AB98847
- Sequence:
QQDGEGHTQD TELVETRPAG DGTFQKWAAV VVPSGEEQRY TCHVQHEGLP EPVTLRWKPA SQPTIPIVGI IAGLVLLGSV VSGAVVAAVI WRKKSSGGKG GSYSKAEWSD SAQGSESHSL
Genular Protein ID: 295782492
Symbol: A8K8M6_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 358
- Mass: 40102
- Checksum: 82A7F8B82520C543
- Sequence:
MVDGTLLLLL SEALALTQTW AGSHSLKYFH TSVSRPGRGE PRFISVGYVD DTQFVRFDND AASPRMVPRA PWMEQEGSEY WDRETRSARD TAQIFRVNLR TLRGYYNQSE AGSHTLQWMH GCELGPDGRF LRGYEQFAYD GKDYLTLNED LRSWTTVDTA AQISEQKSND ASEAEHQRAY LEDTCVEWLH KYLEKGKETL LHLEPPKTHV THHPISDHEA TLRCWALGFY PAEITLTWQQ DGEGHTQDTE LVETRPAGDG TFQKWAAVVV PSGEEQRYTC HVQHEGLPEP VTLRWKPASQ PTIPIVGIIA GLVLLGSLVS GAVVAAVIWR KKSSGGKGGS YSKAEWSDSA QGSESHSL
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.