Details for: GRIN2A

Gene ID: 2903

Symbol: GRIN2A

Ensembl ID: ENSG00000183454

Description: glutamate ionotropic receptor NMDA type subunit 2A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 129.0131
    Cell Significance Index: -60.9100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 6.5139
    Cell Significance Index: 438.0000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 5.9090
    Cell Significance Index: 168.6300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 5.1261
    Cell Significance Index: 1838.6300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.2059
    Cell Significance Index: -9.2100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 3.5140
    Cell Significance Index: 704.9000
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 3.3734
    Cell Significance Index: 45.0000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 2.6661
    Cell Significance Index: 117.9300
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 2.4590
    Cell Significance Index: 31.8900
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.4324
    Cell Significance Index: 30.1700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 2.2008
    Cell Significance Index: 83.3400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 2.0765
    Cell Significance Index: 127.6300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.8746
    Cell Significance Index: 1190.5500
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.5150
    Cell Significance Index: 11.6200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.4567
    Cell Significance Index: 1007.4900
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.4325
    Cell Significance Index: 13.6300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.4036
    Cell Significance Index: 19.9800
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.0328
    Cell Significance Index: 24.7700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.7790
    Cell Significance Index: 13.3500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.6825
    Cell Significance Index: 1285.0400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6664
    Cell Significance Index: 126.8200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3972
    Cell Significance Index: 358.6300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.3394
    Cell Significance Index: 625.9100
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: 0.2493
    Cell Significance Index: 2.7500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.2226
    Cell Significance Index: 101.0100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1972
    Cell Significance Index: 19.5100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0535
    Cell Significance Index: 82.3300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0116
    Cell Significance Index: -1.8900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0136
    Cell Significance Index: -18.5500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0421
    Cell Significance Index: -1.4800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0619
    Cell Significance Index: -1.5900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0773
    Cell Significance Index: -1.6400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0788
    Cell Significance Index: -57.7900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0806
    Cell Significance Index: -59.7300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0976
    Cell Significance Index: -53.3200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1021
    Cell Significance Index: -57.5700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.1040
    Cell Significance Index: -45.9800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1062
    Cell Significance Index: -2.1000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1065
    Cell Significance Index: -66.5300
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1091
    Cell Significance Index: -1.3600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1169
    Cell Significance Index: -7.1700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1185
    Cell Significance Index: -17.2200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1378
    Cell Significance Index: -3.9700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1494
    Cell Significance Index: -2.1400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1611
    Cell Significance Index: -3.2400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.1634
    Cell Significance Index: -1.7800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1725
    Cell Significance Index: -4.8200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1735
    Cell Significance Index: -18.0700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1791
    Cell Significance Index: -51.5300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.2116
    Cell Significance Index: -42.0000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2175
    Cell Significance Index: -4.7000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.2194
    Cell Significance Index: -23.8600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.2465
    Cell Significance Index: -44.4300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2550
    Cell Significance Index: -6.3800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3019
    Cell Significance Index: -63.5900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3124
    Cell Significance Index: -9.9500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.3228
    Cell Significance Index: -14.6300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.3319
    Cell Significance Index: -14.4300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.3420
    Cell Significance Index: -58.3900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3522
    Cell Significance Index: -27.0300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.3758
    Cell Significance Index: -46.2100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.4292
    Cell Significance Index: -58.9400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4456
    Cell Significance Index: -51.9300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.4506
    Cell Significance Index: -58.2100
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.4659
    Cell Significance Index: -5.8800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.4698
    Cell Significance Index: -60.2300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.5192
    Cell Significance Index: -59.4800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.5299
    Cell Significance Index: -36.6500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.5310
    Cell Significance Index: -62.6200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.5653
    Cell Significance Index: -57.7500
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.5914
    Cell Significance Index: -6.9000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.5981
    Cell Significance Index: -14.9200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.6275
    Cell Significance Index: -39.5500
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.6411
    Cell Significance Index: -8.0900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6417
    Cell Significance Index: -21.0100
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.6528
    Cell Significance Index: -9.1500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.7109
    Cell Significance Index: -42.6800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.7660
    Cell Significance Index: -40.2200
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.7810
    Cell Significance Index: -9.3400
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.7907
    Cell Significance Index: -7.5000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.8017
    Cell Significance Index: -56.7000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.8040
    Cell Significance Index: -59.9200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.8541
    Cell Significance Index: -29.9200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.9438
    Cell Significance Index: -52.9600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.9619
    Cell Significance Index: -50.1100
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.9886
    Cell Significance Index: -13.1800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.0829
    Cell Significance Index: -23.4600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -1.1889
    Cell Significance Index: -61.7600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -1.2139
    Cell Significance Index: -57.0500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -1.3027
    Cell Significance Index: -60.7400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -1.3703
    Cell Significance Index: -29.2900
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: -1.3962
    Cell Significance Index: -10.9500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.3974
    Cell Significance Index: -48.5600
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -1.5084
    Cell Significance Index: -10.2200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -1.5193
    Cell Significance Index: -31.7100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.5666
    Cell Significance Index: -57.5100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.5831
    Cell Significance Index: -46.6300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -1.6100
    Cell Significance Index: -18.2900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -1.6138
    Cell Significance Index: -32.1800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.6526
    Cell Significance Index: -52.9300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** GRIN2A is a glutamate receptor ionotropic NMDA receptor subunit, which is composed of four amino acid repeats. It is a critical component of the NMDA receptor complex, which is responsible for mediating excitatory neurotransmission in the brain. GRIN2A is characterized by its ability to bind glutamate and activate the NMDA receptor, leading to an influx of calcium ions into the neuron. This calcium influx is essential for synaptic plasticity, learning, and memory. **Pathways and Functions** GRIN2A is involved in various signaling pathways, including: 1. **Activation of cysteine-type endopeptidase activity**: GRIN2A is involved in the regulation of cysteine-type endopeptidase activity, which is essential for the degradation of neurotransmitters and the regulation of synaptic transmission. 2. **Activation of NMDA receptors and postsynaptic events**: GRIN2A is a critical component of the NMDA receptor complex, which is responsible for mediating excitatory postsynaptic potential and long-term potentiation. 3. **Amyloid-beta binding**: GRIN2A is involved in the binding of amyloid-beta peptides, which are associated with Alzheimer's disease. 4. **Calcium-mediated signaling**: GRIN2A is involved in the regulation of calcium-mediated signaling, which is essential for synaptic plasticity and learning. **Clinical Significance** GRIN2A is involved in various neurological and psychiatric disorders, including: 1. **Alzheimer's disease**: GRIN2A is associated with amyloid-beta binding and is thought to play a role in the pathogenesis of Alzheimer's disease. 2. **Schizophrenia**: GRIN2A is involved in the regulation of glutamatergic neurotransmission, which is thought to be disrupted in schizophrenia. 3. **Depression**: GRIN2A is involved in the regulation of glutamatergic neurotransmission, which is thought to be disrupted in depression. 4. **Neurodevelopmental disorders**: GRIN2A is involved in the regulation of neuronal development and synaptic plasticity, which is thought to be disrupted in neurodevelopmental disorders such as autism and ADHD. In conclusion, GRIN2A is a critical component of the NMDA receptor complex, which plays a pivotal role in synaptic plasticity, learning, and memory. Its dysregulation is associated with various neurological and psychiatric disorders, highlighting the importance of GRIN2A in maintaining normal brain function.

Genular Protein ID: 2967465034

Symbol: NMDE1_HUMAN

Name: Glutamate [NMDA] receptor subunit epsilon-1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8061049

Title: Human N-methyl-D-aspartate receptor modulatory subunit hNR2A: cloning and sequencing of the cDNA and primary structure of the protein.

PubMed ID: 8061049

DOI: 10.1016/0167-4889(94)90086-8

PubMed ID: 8768735

Title: Cloning and functional characterization of human heteromeric N-methyl-D-aspartate receptors.

PubMed ID: 8768735

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 26919761

Title: Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design.

PubMed ID: 26919761

DOI: 10.1021/acs.jmedchem.5b02010

PubMed ID: 26875626

Title: Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function.

PubMed ID: 26875626

DOI: 10.1016/j.neuron.2016.01.016

PubMed ID: 28105280

Title: GluN2A-Selective Pyridopyrimidinone Series of NMDAR Positive Allosteric Modulators with an Improved in Vivo Profile.

PubMed ID: 28105280

DOI: 10.1021/acsmedchemlett.6b00388

PubMed ID: 20890276

Title: Mutations in GRIN2A and GRIN2B encoding regulatory subunits of NMDA receptors cause variable neurodevelopmental phenotypes.

PubMed ID: 20890276

DOI: 10.1038/ng.677

PubMed ID: 21499247

Title: Exome sequencing identifies GRIN2A as frequently mutated in melanoma.

PubMed ID: 21499247

DOI: 10.1038/ng.810

PubMed ID: 22833210

Title: Rare mutations in N-methyl-D-aspartate glutamate receptors in autism spectrum disorders and schizophrenia.

PubMed ID: 22833210

DOI: 10.1038/tp.2011.52

PubMed ID: 23033978

Title: Diagnostic exome sequencing in persons with severe intellectual disability.

PubMed ID: 23033978

DOI: 10.1056/nejmoa1206524

PubMed ID: 23933820

Title: GRIN2A mutations in acquired epileptic aphasia and related childhood focal epilepsies and encephalopathies with speech and language dysfunction.

PubMed ID: 23933820

DOI: 10.1038/ng.2726

PubMed ID: 23933819

Title: Mutations in GRIN2A cause idiopathic focal epilepsy with rolandic spikes.

PubMed ID: 23933819

DOI: 10.1038/ng.2728

PubMed ID: 23933818

Title: GRIN2A mutations cause epilepsy-aphasia spectrum disorders.

PubMed ID: 23933818

DOI: 10.1038/ng.2727

PubMed ID: 24455489

Title: Evidence that GRIN2A mutations in melanoma correlate with decreased survival.

PubMed ID: 24455489

DOI: 10.3389/fonc.2013.00333

PubMed ID: 24903190

Title: Whole-exome sequencing in an individual with severe global developmental delay and intractable epilepsy identifies a novel, de novo GRIN2A mutation.

PubMed ID: 24903190

DOI: 10.1111/epi.12663

PubMed ID: 24504326

Title: Functional analysis of a de novo GRIN2A missense mutation associated with early-onset epileptic encephalopathy.

PubMed ID: 24504326

DOI: 10.1038/ncomms4251

PubMed ID: 26637798

Title: Targeted DNA Sequencing from Autism Spectrum Disorder Brains Implicates Multiple Genetic Mechanisms.

PubMed ID: 26637798

DOI: 10.1016/j.neuron.2015.11.009

PubMed ID: 27839871

Title: Mechanistic insight into NMDA receptor dysregulation by rare variants in the GluN2A and GluN2B agonist binding domains.

PubMed ID: 27839871

DOI: 10.1016/j.ajhg.2016.10.002

PubMed ID: 27288002

Title: Altered zinc sensitivity of NMDA receptors harboring clinically-relevant mutations.

PubMed ID: 27288002

DOI: 10.1016/j.neuropharm.2016.06.008

PubMed ID: 27864847

Title: Diagnostic targeted resequencing in 349 patients with drug-resistant pediatric epilepsies identifies causative mutations in 30 different genes.

PubMed ID: 27864847

DOI: 10.1002/humu.23149

PubMed ID: 28126851

Title: Functional evaluation of a de novo GRIN2A mutation identified in a patient with profound global developmental delay and refractory epilepsy.

PubMed ID: 28126851

DOI: 10.1124/mol.116.106781

PubMed ID: 28182669

Title: A de novo loss-of-function GRIN2A mutation associated with childhood focal epilepsy and acquired epileptic aphasia.

PubMed ID: 28182669

DOI: 10.1371/journal.pone.0170818

PubMed ID: 28095420

Title: Molecular mechanism of disease-associated mutations in the pre-M1 helix of NMDA receptors and potential rescue pharmacology.

PubMed ID: 28095420

DOI: 10.1371/journal.pgen.1006536

PubMed ID: 28242877

Title: Epilepsy-associated GRIN2A mutations reduce NMDA receptor trafficking and agonist potency - molecular profiling and functional rescue.

PubMed ID: 28242877

DOI: 10.1038/s41598-017-00115-w

PubMed ID: 29644724

Title: A novel missense mutation in GRIN2A causes a nonepileptic neurodevelopmental disorder.

PubMed ID: 29644724

DOI: 10.1002/mds.27315

PubMed ID: 30544257

Title: GRIN2A-related disorders: genotype and functional consequence predict phenotype.

PubMed ID: 30544257

DOI: 10.1093/brain/awy304

PubMed ID: 36117210

Title: Complex functional phenotypes of NMDA receptor disease variants.

PubMed ID: 36117210

DOI: 10.1038/s41380-022-01774-6

PubMed ID: 35396579

Title: Rare coding variants in ten genes confer substantial risk for schizophrenia.

PubMed ID: 35396579

DOI: 10.1038/s41586-022-04556-w

PubMed ID: 38538865

Title: De novo GRIN variants in M3 helix associated with neurological disorders control channel gating of NMDA receptor.

PubMed ID: 38538865

DOI: 10.1007/s00018-023-05069-z

PubMed ID: 38307912

Title: Differential functional consequences of GRIN2A mutations associated with schizophrenia and neurodevelopmental disorders.

PubMed ID: 38307912

DOI: 10.1038/s41598-024-53102-3

Sequence Information:

  • Length: 1464
  • Mass: 165283
  • Checksum: AF5EDD599EC0B1E3
  • Sequence:
  • MGRVGYWTLL VLPALLVWRG PAPSAAAEKG PPALNIAVML GHSHDVTERE LRTLWGPEQA 
    AGLPLDVNVV ALLMNRTDPK SLITHVCDLM SGARIHGLVF GDDTDQEAVA QMLDFISSHT 
    FVPILGIHGG ASMIMADKDP TSTFFQFGAS IQQQATVMLK IMQDYDWHVF SLVTTIFPGY 
    REFISFVKTT VDNSFVGWDM QNVITLDTSF EDAKTQVQLK KIHSSVILLY CSKDEAVLIL 
    SEARSLGLTG YDFFWIVPSL VSGNTELIPK EFPSGLISVS YDDWDYSLEA RVRDGIGILT 
    TAASSMLEKF SYIPEAKASC YGQMERPEVP MHTLHPFMVN VTWDGKDLSF TEEGYQVHPR 
    LVVIVLNKDR EWEKVGKWEN HTLSLRHAVW PRYKSFSDCE PDDNHLSIVT LEEAPFVIVE 
    DIDPLTETCV RNTVPCRKFV KINNSTNEGM NVKKCCKGFC IDILKKLSRT VKFTYDLYLV 
    TNGKHGKKVN NVWNGMIGEV VYQRAVMAVG SLTINEERSE VVDFSVPFVE TGISVMVSRS 
    NGTVSPSAFL EPFSASVWVM MFVMLLIVSA IAVFVFEYFS PVGYNRNLAK GKAPHGPSFT 
    IGKAIWLLWG LVFNNSVPVQ NPKGTTSKIM VSVWAFFAVI FLASYTANLA AFMIQEEFVD 
    QVTGLSDKKF QRPHDYSPPF RFGTVPNGST ERNIRNNYPY MHQYMTKFNQ KGVEDALVSL 
    KTGKLDAFIY DAAVLNYKAG RDEGCKLVTI GSGYIFATTG YGIALQKGSP WKRQIDLALL 
    QFVGDGEMEE LETLWLTGIC HNEKNEVMSS QLDIDNMAGV FYMLAAAMAL SLITFIWEHL 
    FYWKLRFCFT GVCSDRPGLL FSISRGIYSC IHGVHIEEKK KSPDFNLTGS QSNMLKLLRS 
    AKNISSMSNM NSSRMDSPKR AADFIQRGSL IMDMVSDKGN LMYSDNRSFQ GKESIFGDNM 
    NELQTFVANR QKDNLNNYVF QGQHPLTLNE SNPNTVEVAV STESKANSRP RQLWKKSVDS 
    IRQDSLSQNP VSQRDEATAE NRTHSLKSPR YLPEEMAHSD ISETSNRATC HREPDNSKNH 
    KTKDNFKRSV ASKYPKDCSE VERTYLKTKS SSPRDKIYTI DGEKEPGFHL DPPQFVENVT 
    LPENVDFPDP YQDPSENFRK GDSTLPMNRN PLHNEEGLSN NDQYKLYSKH FTLKDKGSPH 
    SETSERYRQN STHCRSCLSN MPTYSGHFTM RSPFKCDACL RMGNLYDIDE DQMLQETGNP 
    ATGEQVYQQD WAQNNALQLQ KNKLRISRQH SYDNIVDKPR ELDLSRPSRS ISLKDRERLL 
    EGNFYGSLFS VPSSKLSGKK SSLFPQGLED SKRSKSLLPD HTSDNPFLHS HRDDQRLVIG 
    RCPSDPYKHS LPSQAVNDSY LRSSLRSTAS YCSRDSRGHN DVYISEHVMP YAANKNNMYS 
    TPRVLNSCSN RRVYKKMPSI ESDV

Genular Protein ID: 2318442707

Symbol: Q59EW6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 1491
  • Mass: 168031
  • Checksum: 05F8E12D0AA8A0D1
  • Sequence:
  • GGRDARARSA PHCILDLLGL QGPSVATMGR VGYWTLLVLP ALLVWRGPAP SAAAEKGPPA 
    LNIAVMLGHS HDVTERELRT LWGPEQAAGL PLDVNVVALL MNRTDPKSLI THVCDLMSGA 
    RIHGLVFGDD TDQEAVAQML DFISSHTFVP ILGIHGGASM IMADKDPTST FFQFGASIQQ 
    QATVMLKIMQ DYDWHVFSLV TTIFPGYREF ISFVKTTVDN SFVGWDMQNV ITLDTSFEDA 
    KTQVQLKKIH SSVILLYCSK DEAVLILSEA RSLGLTGYDF FWIVPSLVSG NTELIPKEFP 
    SGLISVSYDD WDYSLEARVR DGIGILTTAA SSMLEKFSYI PEAKASCYGQ MERPEVPMHT 
    LHPFMVNVTW DGKDLSFTEE GYQVHPRLVV IVLNKDREWE KVGKWENHTL SLRHAVWPRY 
    KSFSDCEPDD NHLSIVTLEE APFVIVEDID PLTETCVRNT VPCRKFVKIN NSTNEGMNVK 
    KCCKGFCIDI LKKLSRTVKF TYDLYLVTNG KHGKKVNNVW NGMIGEVVYQ RAVMAVGSLT 
    INEERSEVVD FSVPFVETGI SVMVSRSNGT VSPSAFLEPF SASVWVMMFV MLLIVSAIAV 
    FVFEYFSPVG YNRNLAKGKA PHGPSFTIGK AIWLLWGLVF NNSVPVQNPK GTTSKIMVSV 
    WAFFAVIFLA SYTANLAAFM IQEEFVDQVT GLSDKKFQRP HDYSPPFRFG TVPNGSTERN 
    IRNNYPYMHQ YMTKFNQKGV EDALVSLKTG KLDAFIYDAA VLNYKAGRDE GCKLVTIGSG 
    YIFATTGYGI ALQKGSPWKR QIDLALLQFV GDGEMEELET LWLTGICHNE KNEVMSSQLD 
    IDNMAGVFYM LAAAMALSLI TFIWEHLFYW KLRFCFTGVC SDRPGLLFSI SRGIYSCIHG 
    VHIEEKKKSP DFNLTGSQSN MLKLLRSAKN ISSMSNMNSS RMDSPKRAAD FIQRGSLIMD 
    MVSDKGNLMY SDNRSFQGKE SIFGDNMNEL QTFVANRQKD NLNNYVFQGQ HPLTLNESNP 
    NTVEVAVSTE SKANSRPRQL WKKSVDSIRQ DSLSQNPVSQ RDEATAENRT HSLKSPRYLP 
    EEMAHSDFSE TSNRATCHRE PDNSKNHKTK DNFKRSVASK YPKDCSEVER TYLKTKSSSP 
    RDKIYTIDGE KEPGFHLDPP QFVENVTLPE NVDFPDPYQD PSENFRKGDS TLPMNRNPLH 
    NEEGLSNNDQ YKLYSKHFTL KDKGSPHSET SERYRQNSTH CRSCLSNMPT YSGHFTMRSP 
    FKCDACLRMG NLYDIDEDQM LQETGNPATG EQVYQQDWAQ NNALQLQKNK LRISRQHSYD 
    NIVDKPRELD LSRPSRSISL KDRERLLEGN FYGSLFSVPS SKLSGKKSSL FPQGLEDSKR 
    SKSLLPDHTS DNPFLHSHRD DQRLVIGRCP SDPYKHSLPS QAVNDSYLRS SLRSTASYCS 
    RDSRGHNDVY ISEHVMPYAA NKNNMYSTPR VLNSCSNRRV YKKMPSIESD V

Genular Protein ID: 2005397464

Symbol: A0A890YTL4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 1281
  • Mass: 144431
  • Checksum: 7454CF24F5BE8373
  • Sequence:
  • MGRVGYWTLL VLPALLVWRG PAPSAAAEKG PPALNIAVML GHSHDVTERE LRTLWGPEQA 
    AGLPLDVNVV ALLMNRTDPK SLITHVCDLM SGARIHGLVF GDDTDQEAVA QMLDFISSHT 
    FVPILGIHGG ASMIMADKDP TSTFFQFGAS IQQQATVMLK IMQDYDWHVF SLVTTIFPGY 
    REFISFVKTT VDNSFVGWDM QNVITLDTSF EDAKTQVQLK KIHSSVILLY CSKDEAVLIL 
    SEARSLGLTG YDFFWIVPSL VSGNTELIPK EFPSGLISVS YDDWDYSLEA RVRDGIGILT 
    TAASSMLEKF SYIPEAKASC YGQMERPEVP MHTLHPFMVN VTWDGKDLSF TEEGYQVHPR 
    LVVIVLNKDR EWEKVGKWEN HTLSLRHAVW PRYKSFSDCE PDDNHLSIVT LEEAPFVIVE 
    DIDPLTETCV RNTVPCRKFV KINNSTNEGM NVKKCCKGFC IDILKKLSRT VKFTYDLYLV 
    TNGKHGKKVN NVWNGMIGEV VYQRAVMAVG SLTINEERSE VVDFSVPFVE TGISVMVSRS 
    NGTVSPSAFL EPFSASVWVM MFVMLLIVSA IAVFVFEYFS PVGYNRNLAK GKAPHGPSFT 
    IGKAIWLLWG LVFNNSVPVQ NPKGTTSKIM VSVWAFFAVI FLASYTANLA AFMIQEEFVD 
    QVTGLSDKKF QRPHDYSPPF RFGTVPNGST ERNIRNNYPY MHQYMTKFNQ KGVEDALVSL 
    KTGKLDAFIY DAAVLNYKAG RDEGCKLVTI GSGYIFATTG YGIALQKGSP WKRQIDLALL 
    QFVGDGEMEE LETLWLTGIC HNEKNEVMSS QLDIDNMAGV FYMLAAAMAL SLITFIWEHL 
    FYWKLRFCFT GVCSDRPGLL FSISRGIYSC IHGVHIEEKK KSPDFNLTGS QSNMLKLLRS 
    AKNISSMSNM NSSRMDSPKR AADFIQRGSL IMDMVSDKGN LMYSDNRSFQ GKESIFGDNM 
    NELQTFVANR QKDNLNNYVF QGQHPLTLNE SNPNTVEVAV STESKANSRP RQLWKKSVDS 
    IRQDSLSQNP VSQRDEATAE NRTHSLKSPR YLPEEMAHSD ISETSNRATC HREPDNSKNH 
    KTKDNFKRSV ASKYPKDCSE VERTYLKTKS SSPRDKIYTI DGEKEPGFHL DPPQFVENVT 
    LPENVDFPDP YQDPSENFRK GDSTLPMNRN PLHNEEGLSN NDQYKLYSKH FTLKDKGSPH 
    SETSERYRQN STHCRSCLSN MPTYSGHFTM RSPFKCDACL RMGNLYDIDE DQMLQETGMT 
    NAWLLGDAPR TLTNTRCHPR R

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.