Details for: GRIN2A

Gene ID: 2903

Symbol: GRIN2A

Ensembl ID: ENSG00000183454

Description: glutamate ionotropic receptor NMDA type subunit 2A

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 3.09
    Marker Score: 8,812
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.93
    Marker Score: 855
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 2.88
    Marker Score: 4,843
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.86
    Marker Score: 42,775
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.76
    Marker Score: 54,920
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 2.61
    Marker Score: 1,170
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.58
    Marker Score: 97,960
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.36
    Marker Score: 9,886
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.33
    Marker Score: 978
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.31
    Marker Score: 8,944
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.26
    Marker Score: 83,343
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.22
    Marker Score: 2,990
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.2
    Marker Score: 20,669
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.08
    Marker Score: 127,818
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 2.06
    Marker Score: 11,076
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.97
    Marker Score: 1,145
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.94
    Marker Score: 2,145
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.93
    Marker Score: 18,301
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.85
    Marker Score: 4,063
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.82
    Marker Score: 574
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.76
    Marker Score: 15,133
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.75
    Marker Score: 18,113
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.74
    Marker Score: 13,373
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.69
    Marker Score: 462
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.66
    Marker Score: 2,557
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.62
    Marker Score: 6,578
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1,166
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.51
    Marker Score: 1,509
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167,890
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.44
    Marker Score: 5,988
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.42
    Marker Score: 2,893
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 1.39
    Marker Score: 3,189
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 867
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.26
    Marker Score: 19,746
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 852
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.22
    Marker Score: 414
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4,800
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.14
    Marker Score: 639
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.13
    Marker Score: 4,733
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.09
    Marker Score: 501
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.08
    Marker Score: 1,240
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.06
    Marker Score: 2,540
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 793
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.01
    Marker Score: 608
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1
    Marker Score: 415
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1
    Marker Score: 2,352
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,800
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,025
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 507
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,406
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 460
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,412
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.95
    Marker Score: 20,227
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.93
    Marker Score: 558
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,323
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 373
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,740
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 325
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.89
    Marker Score: 425
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.88
    Marker Score: 404
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,285
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,261
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 699
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.75
    Marker Score: 499
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.75
    Marker Score: 1,450
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.75
    Marker Score: 2,657
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.74
    Marker Score: 1,507
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.73
    Marker Score: 4,844
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 460
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.72
    Marker Score: 7,286
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.71
    Marker Score: 1,293
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 0.7
    Marker Score: 232
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.69
    Marker Score: 455
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.65
    Marker Score: 209
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.65
    Marker Score: 203
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.65
    Marker Score: 168
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.63
    Marker Score: 766
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.63
    Marker Score: 278
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.61
    Marker Score: 219
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.58
    Marker Score: 2,704
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.57
    Marker Score: 453
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 0.56
    Marker Score: 2,939
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 233
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.54
    Marker Score: 266
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.53
    Marker Score: 659
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 0.52
    Marker Score: 147
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.49
    Marker Score: 468
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.49
    Marker Score: 286
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.49
    Marker Score: 525
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.49
    Marker Score: 10,865
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.48
    Marker Score: 901
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.44
    Marker Score: 139
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.44
    Marker Score: 480
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0.42
    Marker Score: 3,195
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.42
    Marker Score: 134
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.42
    Marker Score: 404
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.42
    Marker Score: 145

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** GRIN2A is a glutamate receptor ionotropic NMDA receptor subunit, which is composed of four amino acid repeats. It is a critical component of the NMDA receptor complex, which is responsible for mediating excitatory neurotransmission in the brain. GRIN2A is characterized by its ability to bind glutamate and activate the NMDA receptor, leading to an influx of calcium ions into the neuron. This calcium influx is essential for synaptic plasticity, learning, and memory. **Pathways and Functions** GRIN2A is involved in various signaling pathways, including: 1. **Activation of cysteine-type endopeptidase activity**: GRIN2A is involved in the regulation of cysteine-type endopeptidase activity, which is essential for the degradation of neurotransmitters and the regulation of synaptic transmission. 2. **Activation of NMDA receptors and postsynaptic events**: GRIN2A is a critical component of the NMDA receptor complex, which is responsible for mediating excitatory postsynaptic potential and long-term potentiation. 3. **Amyloid-beta binding**: GRIN2A is involved in the binding of amyloid-beta peptides, which are associated with Alzheimer's disease. 4. **Calcium-mediated signaling**: GRIN2A is involved in the regulation of calcium-mediated signaling, which is essential for synaptic plasticity and learning. **Clinical Significance** GRIN2A is involved in various neurological and psychiatric disorders, including: 1. **Alzheimer's disease**: GRIN2A is associated with amyloid-beta binding and is thought to play a role in the pathogenesis of Alzheimer's disease. 2. **Schizophrenia**: GRIN2A is involved in the regulation of glutamatergic neurotransmission, which is thought to be disrupted in schizophrenia. 3. **Depression**: GRIN2A is involved in the regulation of glutamatergic neurotransmission, which is thought to be disrupted in depression. 4. **Neurodevelopmental disorders**: GRIN2A is involved in the regulation of neuronal development and synaptic plasticity, which is thought to be disrupted in neurodevelopmental disorders such as autism and ADHD. In conclusion, GRIN2A is a critical component of the NMDA receptor complex, which plays a pivotal role in synaptic plasticity, learning, and memory. Its dysregulation is associated with various neurological and psychiatric disorders, highlighting the importance of GRIN2A in maintaining normal brain function.

Genular Protein ID: 2967465034

Symbol: NMDE1_HUMAN

Name: Glutamate receptor ionotropic, NMDA 2A

UniProtKB Accession Codes:

Q12879 O00669 Q17RZ6

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CORUM 1 CTD 1 ChEBI 8 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 28 DrugCentral 1 EMBL 9 EMDB 11 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 52 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 5 OrthoDB 1 PANTHER 2 PDB 38 PDBsum 22 PIR 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 7 RefSeq 4 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8061049

Title: Human N-methyl-D-aspartate receptor modulatory subunit hNR2A: cloning and sequencing of the cDNA and primary structure of the protein.

PubMed ID: 8061049

DOI: 10.1016/0167-4889(94)90086-8

PubMed ID: 8768735

Title: Cloning and functional characterization of human heteromeric N-methyl-D-aspartate receptors.

PubMed ID: 8768735

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 26919761

Title: Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design.

PubMed ID: 26919761

DOI: 10.1021/acs.jmedchem.5b02010

PubMed ID: 26875626

Title: Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function.

PubMed ID: 26875626

DOI: 10.1016/j.neuron.2016.01.016

PubMed ID: 28105280

Title: GluN2A-Selective Pyridopyrimidinone Series of NMDAR Positive Allosteric Modulators with an Improved in Vivo Profile.

PubMed ID: 28105280

DOI: 10.1021/acsmedchemlett.6b00388

PubMed ID: 20890276

Title: Mutations in GRIN2A and GRIN2B encoding regulatory subunits of NMDA receptors cause variable neurodevelopmental phenotypes.

PubMed ID: 20890276

DOI: 10.1038/ng.677

PubMed ID: 21499247

Title: Exome sequencing identifies GRIN2A as frequently mutated in melanoma.

PubMed ID: 21499247

DOI: 10.1038/ng.810

PubMed ID: 22833210

Title: Rare mutations in N-methyl-D-aspartate glutamate receptors in autism spectrum disorders and schizophrenia.

PubMed ID: 22833210

DOI: 10.1038/tp.2011.52

PubMed ID: 23033978

Title: Diagnostic exome sequencing in persons with severe intellectual disability.

PubMed ID: 23033978

DOI: 10.1056/nejmoa1206524

PubMed ID: 23933820

Title: GRIN2A mutations in acquired epileptic aphasia and related childhood focal epilepsies and encephalopathies with speech and language dysfunction.

PubMed ID: 23933820

DOI: 10.1038/ng.2726

PubMed ID: 23933819

Title: Mutations in GRIN2A cause idiopathic focal epilepsy with rolandic spikes.

PubMed ID: 23933819

DOI: 10.1038/ng.2728

PubMed ID: 23933818

Title: GRIN2A mutations cause epilepsy-aphasia spectrum disorders.

PubMed ID: 23933818

DOI: 10.1038/ng.2727

PubMed ID: 24455489

Title: Evidence that GRIN2A mutations in melanoma correlate with decreased survival.

PubMed ID: 24455489

DOI: 10.3389/fonc.2013.00333

PubMed ID: 24903190

Title: Whole-exome sequencing in an individual with severe global developmental delay and intractable epilepsy identifies a novel, de novo GRIN2A mutation.

PubMed ID: 24903190

DOI: 10.1111/epi.12663

PubMed ID: 24504326

Title: Functional analysis of a de novo GRIN2A missense mutation associated with early-onset epileptic encephalopathy.

PubMed ID: 24504326

DOI: 10.1038/ncomms4251

PubMed ID: 26637798

Title: Targeted DNA Sequencing from Autism Spectrum Disorder Brains Implicates Multiple Genetic Mechanisms.

PubMed ID: 26637798

DOI: 10.1016/j.neuron.2015.11.009

PubMed ID: 27839871

Title: Mechanistic insight into NMDA receptor dysregulation by rare variants in the GluN2A and GluN2B agonist binding domains.

PubMed ID: 27839871

DOI: 10.1016/j.ajhg.2016.10.002

PubMed ID: 27864847

Title: Diagnostic targeted resequencing in 349 patients with drug-resistant pediatric epilepsies identifies causative mutations in 30 different genes.

PubMed ID: 27864847

DOI: 10.1002/humu.23149

PubMed ID: 28126851

Title: Functional evaluation of a de novo GRIN2A mutation identified in a patient with profound global developmental delay and refractory epilepsy.

PubMed ID: 28126851

DOI: 10.1124/mol.116.106781

PubMed ID: 28182669

Title: A de novo loss-of-function GRIN2A mutation associated with childhood focal epilepsy and acquired epileptic aphasia.

PubMed ID: 28182669

DOI: 10.1371/journal.pone.0170818

PubMed ID: 28095420

Title: Molecular mechanism of disease-associated mutations in the pre-M1 helix of NMDA receptors and potential rescue pharmacology.

PubMed ID: 28095420

DOI: 10.1371/journal.pgen.1006536

Sequence Information:

  • Length: 1464
  • Mass: 165283
  • Checksum: AF5EDD599EC0B1E3
  • Sequence:
    • MGRVGYWTLL VLPALLVWRG PAPSAAAEKG PPALNIAVML GHSHDVTERE LRTLWGPEQA 
AGLPLDVNVV ALLMNRTDPK SLITHVCDLM SGARIHGLVF GDDTDQEAVA QMLDFISSHT 
FVPILGIHGG ASMIMADKDP TSTFFQFGAS IQQQATVMLK IMQDYDWHVF SLVTTIFPGY 
REFISFVKTT VDNSFVGWDM QNVITLDTSF EDAKTQVQLK KIHSSVILLY CSKDEAVLIL 
SEARSLGLTG YDFFWIVPSL VSGNTELIPK EFPSGLISVS YDDWDYSLEA RVRDGIGILT 
TAASSMLEKF SYIPEAKASC YGQMERPEVP MHTLHPFMVN VTWDGKDLSF TEEGYQVHPR 
LVVIVLNKDR EWEKVGKWEN HTLSLRHAVW PRYKSFSDCE PDDNHLSIVT LEEAPFVIVE 
DIDPLTETCV RNTVPCRKFV KINNSTNEGM NVKKCCKGFC IDILKKLSRT VKFTYDLYLV 
TNGKHGKKVN NVWNGMIGEV VYQRAVMAVG SLTINEERSE VVDFSVPFVE TGISVMVSRS 
NGTVSPSAFL EPFSASVWVM MFVMLLIVSA IAVFVFEYFS PVGYNRNLAK GKAPHGPSFT 
IGKAIWLLWG LVFNNSVPVQ NPKGTTSKIM VSVWAFFAVI FLASYTANLA AFMIQEEFVD 
QVTGLSDKKF QRPHDYSPPF RFGTVPNGST ERNIRNNYPY MHQYMTKFNQ KGVEDALVSL 
KTGKLDAFIY DAAVLNYKAG RDEGCKLVTI GSGYIFATTG YGIALQKGSP WKRQIDLALL 
QFVGDGEMEE LETLWLTGIC HNEKNEVMSS QLDIDNMAGV FYMLAAAMAL SLITFIWEHL 
FYWKLRFCFT GVCSDRPGLL FSISRGIYSC IHGVHIEEKK KSPDFNLTGS QSNMLKLLRS 
AKNISSMSNM NSSRMDSPKR AADFIQRGSL IMDMVSDKGN LMYSDNRSFQ GKESIFGDNM 
NELQTFVANR QKDNLNNYVF QGQHPLTLNE SNPNTVEVAV STESKANSRP RQLWKKSVDS 
IRQDSLSQNP VSQRDEATAE NRTHSLKSPR YLPEEMAHSD ISETSNRATC HREPDNSKNH 
KTKDNFKRSV ASKYPKDCSE VERTYLKTKS SSPRDKIYTI DGEKEPGFHL DPPQFVENVT 
LPENVDFPDP YQDPSENFRK GDSTLPMNRN PLHNEEGLSN NDQYKLYSKH FTLKDKGSPH 
SETSERYRQN STHCRSCLSN MPTYSGHFTM RSPFKCDACL RMGNLYDIDE DQMLQETGNP 
ATGEQVYQQD WAQNNALQLQ KNKLRISRQH SYDNIVDKPR ELDLSRPSRS ISLKDRERLL 
EGNFYGSLFS VPSSKLSGKK SSLFPQGLED SKRSKSLLPD HTSDNPFLHS HRDDQRLVIG 
RCPSDPYKHS LPSQAVNDSY LRSSLRSTAS YCSRDSRGHN DVYISEHVMP YAANKNNMYS 
TPRVLNSCSN RRVYKKMPSI ESDV

Genular Protein ID: 2318442707

Symbol: Q59EW6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59EW6

Database IDs:

ARBA 20 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 EMBL 2 GO 3 Gene3D 2 Genevisible 1 GenomeRNAi 1 InterPro 8 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 RefSeq 1 RuleBase 1 SAM 1 SMART 4 SUPFAM 2

Sequence Information:

  • Length: 1491
  • Mass: 168031
  • Checksum: 05F8E12D0AA8A0D1
  • Sequence:
    • GGRDARARSA PHCILDLLGL QGPSVATMGR VGYWTLLVLP ALLVWRGPAP SAAAEKGPPA 
LNIAVMLGHS HDVTERELRT LWGPEQAAGL PLDVNVVALL MNRTDPKSLI THVCDLMSGA 
RIHGLVFGDD TDQEAVAQML DFISSHTFVP ILGIHGGASM IMADKDPTST FFQFGASIQQ 
QATVMLKIMQ DYDWHVFSLV TTIFPGYREF ISFVKTTVDN SFVGWDMQNV ITLDTSFEDA 
KTQVQLKKIH SSVILLYCSK DEAVLILSEA RSLGLTGYDF FWIVPSLVSG NTELIPKEFP 
SGLISVSYDD WDYSLEARVR DGIGILTTAA SSMLEKFSYI PEAKASCYGQ MERPEVPMHT 
LHPFMVNVTW DGKDLSFTEE GYQVHPRLVV IVLNKDREWE KVGKWENHTL SLRHAVWPRY 
KSFSDCEPDD NHLSIVTLEE APFVIVEDID PLTETCVRNT VPCRKFVKIN NSTNEGMNVK 
KCCKGFCIDI LKKLSRTVKF TYDLYLVTNG KHGKKVNNVW NGMIGEVVYQ RAVMAVGSLT 
INEERSEVVD FSVPFVETGI SVMVSRSNGT VSPSAFLEPF SASVWVMMFV MLLIVSAIAV 
FVFEYFSPVG YNRNLAKGKA PHGPSFTIGK AIWLLWGLVF NNSVPVQNPK GTTSKIMVSV 
WAFFAVIFLA SYTANLAAFM IQEEFVDQVT GLSDKKFQRP HDYSPPFRFG TVPNGSTERN 
IRNNYPYMHQ YMTKFNQKGV EDALVSLKTG KLDAFIYDAA VLNYKAGRDE GCKLVTIGSG 
YIFATTGYGI ALQKGSPWKR QIDLALLQFV GDGEMEELET LWLTGICHNE KNEVMSSQLD 
IDNMAGVFYM LAAAMALSLI TFIWEHLFYW KLRFCFTGVC SDRPGLLFSI SRGIYSCIHG 
VHIEEKKKSP DFNLTGSQSN MLKLLRSAKN ISSMSNMNSS RMDSPKRAAD FIQRGSLIMD 
MVSDKGNLMY SDNRSFQGKE SIFGDNMNEL QTFVANRQKD NLNNYVFQGQ HPLTLNESNP 
NTVEVAVSTE SKANSRPRQL WKKSVDSIRQ DSLSQNPVSQ RDEATAENRT HSLKSPRYLP 
EEMAHSDFSE TSNRATCHRE PDNSKNHKTK DNFKRSVASK YPKDCSEVER TYLKTKSSSP 
RDKIYTIDGE KEPGFHLDPP QFVENVTLPE NVDFPDPYQD PSENFRKGDS TLPMNRNPLH 
NEEGLSNNDQ YKLYSKHFTL KDKGSPHSET SERYRQNSTH CRSCLSNMPT YSGHFTMRSP 
FKCDACLRMG NLYDIDEDQM LQETGNPATG EQVYQQDWAQ NNALQLQKNK LRISRQHSYD 
NIVDKPRELD LSRPSRSISL KDRERLLEGN FYGSLFSVPS SKLSGKKSSL FPQGLEDSKR 
SKSLLPDHTS DNPFLHSHRD DQRLVIGRCP SDPYKHSLPS QAVNDSYLRS SLRSTASYCS 
RDSRGHNDVY ISEHVMPYAA NKNNMYSTPR VLNSCSNRRV YKKMPSIESD V

Genular Protein ID: 2005397464

Symbol: A0A890YTL4_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A890YTL4

Database IDs:

ARBA 20 CDD 2 CTD 1 EMBL 2 GO 3 Gene3D 2 InterPro 8 NCBI Taxonomy 1 PANTHER 2 PRINTS 1 Pfam 5 RefSeq 2 RuleBase 1 SAM 1 SMART 4 SMR 1 SUPFAM 2

Sequence Information:

  • Length: 1281
  • Mass: 144431
  • Checksum: 7454CF24F5BE8373
  • Sequence:
    • MGRVGYWTLL VLPALLVWRG PAPSAAAEKG PPALNIAVML GHSHDVTERE LRTLWGPEQA 
AGLPLDVNVV ALLMNRTDPK SLITHVCDLM SGARIHGLVF GDDTDQEAVA QMLDFISSHT 
FVPILGIHGG ASMIMADKDP TSTFFQFGAS IQQQATVMLK IMQDYDWHVF SLVTTIFPGY 
REFISFVKTT VDNSFVGWDM QNVITLDTSF EDAKTQVQLK KIHSSVILLY CSKDEAVLIL 
SEARSLGLTG YDFFWIVPSL VSGNTELIPK EFPSGLISVS YDDWDYSLEA RVRDGIGILT 
TAASSMLEKF SYIPEAKASC YGQMERPEVP MHTLHPFMVN VTWDGKDLSF TEEGYQVHPR 
LVVIVLNKDR EWEKVGKWEN HTLSLRHAVW PRYKSFSDCE PDDNHLSIVT LEEAPFVIVE 
DIDPLTETCV RNTVPCRKFV KINNSTNEGM NVKKCCKGFC IDILKKLSRT VKFTYDLYLV 
TNGKHGKKVN NVWNGMIGEV VYQRAVMAVG SLTINEERSE VVDFSVPFVE TGISVMVSRS 
NGTVSPSAFL EPFSASVWVM MFVMLLIVSA IAVFVFEYFS PVGYNRNLAK GKAPHGPSFT 
IGKAIWLLWG LVFNNSVPVQ NPKGTTSKIM VSVWAFFAVI FLASYTANLA AFMIQEEFVD 
QVTGLSDKKF QRPHDYSPPF RFGTVPNGST ERNIRNNYPY MHQYMTKFNQ KGVEDALVSL 
KTGKLDAFIY DAAVLNYKAG RDEGCKLVTI GSGYIFATTG YGIALQKGSP WKRQIDLALL 
QFVGDGEMEE LETLWLTGIC HNEKNEVMSS QLDIDNMAGV FYMLAAAMAL SLITFIWEHL 
FYWKLRFCFT GVCSDRPGLL FSISRGIYSC IHGVHIEEKK KSPDFNLTGS QSNMLKLLRS 
AKNISSMSNM NSSRMDSPKR AADFIQRGSL IMDMVSDKGN LMYSDNRSFQ GKESIFGDNM 
NELQTFVANR QKDNLNNYVF QGQHPLTLNE SNPNTVEVAV STESKANSRP RQLWKKSVDS 
IRQDSLSQNP VSQRDEATAE NRTHSLKSPR YLPEEMAHSD ISETSNRATC HREPDNSKNH 
KTKDNFKRSV ASKYPKDCSE VERTYLKTKS SSPRDKIYTI DGEKEPGFHL DPPQFVENVT 
LPENVDFPDP YQDPSENFRK GDSTLPMNRN PLHNEEGLSN NDQYKLYSKH FTLKDKGSPH 
SETSERYRQN STHCRSCLSN MPTYSGHFTM RSPFKCDACL RMGNLYDIDE DQMLQETGMT 
NAWLLGDAPR TLTNTRCHPR R

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.