Details for: HNRNPA2B1

Gene ID: 3181

Symbol: HNRNPA2B1

Ensembl ID: ENSG00000122566

Description: heterogeneous nuclear ribonucleoprotein A2/B1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 5.97
    Marker Score: 24897
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 4.85
    Marker Score: 3794
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 4.75
    Marker Score: 1751
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 4.61
    Marker Score: 3491.5
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 4.58
    Marker Score: 7054
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 4.38
    Marker Score: 148930.5
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 4.37
    Marker Score: 43310
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 4.3
    Marker Score: 1028
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 4.18
    Marker Score: 13193
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 4.07
    Marker Score: 215457
  • Cell Name: blood cell (CL0000081)
    Fold Change: 4.06
    Marker Score: 47146
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 4.04
    Marker Score: 11787
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 4.02
    Marker Score: 54077
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 3.97
    Marker Score: 52384
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 3.96
    Marker Score: 1783
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 3.96
    Marker Score: 1774
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 3.95
    Marker Score: 10045
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 3.94
    Marker Score: 3361.5
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.94
    Marker Score: 9627
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 3.92
    Marker Score: 11005.5
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 3.88
    Marker Score: 3748
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 3.88
    Marker Score: 2925
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 3.88
    Marker Score: 1351.5
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.87
    Marker Score: 4134
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 3.84
    Marker Score: 10292
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 3.83
    Marker Score: 4482.5
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 3.82
    Marker Score: 2999
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 3.81
    Marker Score: 33471
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 3.8
    Marker Score: 870
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 3.79
    Marker Score: 7943.5
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 3.77
    Marker Score: 2426
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 3.76
    Marker Score: 1531
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 3.73
    Marker Score: 15991
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 3.71
    Marker Score: 3317
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.71
    Marker Score: 207732
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 3.71
    Marker Score: 10253
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 3.68
    Marker Score: 4445.5
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 3.63
    Marker Score: 2268
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 3.61
    Marker Score: 1463
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 3.58
    Marker Score: 3213
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 3.57
    Marker Score: 2927
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 3.57
    Marker Score: 3880
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 3.55
    Marker Score: 3498
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 3.53
    Marker Score: 5201
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 3.53
    Marker Score: 3101
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 3.53
    Marker Score: 8610
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 3.52
    Marker Score: 1003
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 3.48
    Marker Score: 3864
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 3.48
    Marker Score: 6211.5
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 3.48
    Marker Score: 921
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 3.46
    Marker Score: 897.5
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 3.46
    Marker Score: 752
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.46
    Marker Score: 22492.5
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 3.46
    Marker Score: 3250
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 3.46
    Marker Score: 3718
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: 3.45
    Marker Score: 857
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 3.44
    Marker Score: 2924
  • Cell Name: lung neuroendocrine cell (CL1000223)
    Fold Change: 3.44
    Marker Score: 971.5
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 3.43
    Marker Score: 8651.5
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 3.43
    Marker Score: 2272.5
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 3.43
    Marker Score: 2008.5
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 3.43
    Marker Score: 1189
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 3.42
    Marker Score: 749
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 3.42
    Marker Score: 851
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 3.42
    Marker Score: 60660.5
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 3.42
    Marker Score: 840
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 3.42
    Marker Score: 795
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 3.41
    Marker Score: 3621
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 3.41
    Marker Score: 1581
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 3.41
    Marker Score: 16743
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 3.41
    Marker Score: 1003
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 3.41
    Marker Score: 3030
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 3.4
    Marker Score: 3212.5
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 3.4
    Marker Score: 1547
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 3.4
    Marker Score: 901
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 3.39
    Marker Score: 6363.5
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 3.37
    Marker Score: 2840
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 3.36
    Marker Score: 1794.5
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 3.36
    Marker Score: 955
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 3.36
    Marker Score: 2541
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 3.36
    Marker Score: 889.5
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 3.36
    Marker Score: 4856.5
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 3.35
    Marker Score: 5499
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 3.35
    Marker Score: 858
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 3.35
    Marker Score: 2952
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 3.35
    Marker Score: 2250
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.34
    Marker Score: 4037
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 3.34
    Marker Score: 810
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 3.34
    Marker Score: 19796
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 3.34
    Marker Score: 12917
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 3.33
    Marker Score: 2228
  • Cell Name: podocyte (CL0000653)
    Fold Change: 3.33
    Marker Score: 1231.5
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 3.33
    Marker Score: 3213.5
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 3.33
    Marker Score: 24779
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 3.33
    Marker Score: 4107
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 3.33
    Marker Score: 5705.5
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 3.32
    Marker Score: 3920
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 3.32
    Marker Score: 6062
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 3.32
    Marker Score: 874
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 3.31
    Marker Score: 1609

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Other Information

**Key characteristics:** * HNRNPA2B1 is a large protein with a molecular weight of approximately 130 kDa. * It is a member of the heterogeneous nuclear ribonucleoprotein (hnRNP) family of proteins. * HNRNPA2B1 is a key regulator of the Jak/STAT signaling pathway, which is involved in the regulation of inflammation and immune responses. * It is also involved in the regulation of telomere maintenance, as it is a major mRNA binding protein and regulates the expression of genes involved in telomere maintenance. **Pathways and functions:** * HNRNPA2B1 is involved in the regulation of the Jak/STAT signaling pathway, a key pathway involved in the regulation of inflammation and immune responses. * It binds to the IL-12 receptor and recruits STAT3, a key component of the Jak/STAT signaling pathway, to the nucleus. * This binding leads to the activation of STAT3, which then regulates the expression of various genes involved in the immune response, including those involved in inflammation and cell growth. * HNRNPA2B1 is also involved in the regulation of telomere maintenance. It binds to single-stranded telomeric DNA and promotes its interaction with the telomerase complex, which is responsible for maintaining telomere length. * In addition to its role in the Jak/STAT signaling pathway and telomere maintenance, HNRNPA2B1 is also involved in other cellular processes, including cell cycle regulation, apoptosis, and migration. **Clinical significance:** * Mutations in HNRNPA2B1 have been linked to the development of several autoimmune diseases, including rheumatoid arthritis, lupus, and asthma. * In these diseases, HNRNPA2B1 is often overexpressed, leading to the dysregulation of the Jak/STAT signaling pathway and the production of inflammatory cytokines. * Therefore, targeting HNRNPA2B1 signaling has emerged as a potential therapeutic strategy for autoimmune diseases.

Genular Protein ID: 3733172738

Symbol: ROA2_HUMAN

Name: Heterogeneous nuclear ribonucleoproteins A2/B1

UniProtKB Accession Codes:

P22626 A0A024RA27 A0A024RA61 A8K064 P22627 Q9UC98 Q9UDJ2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 2 EMBL 13 EMDB 2 EPD 1 Ensembl 32 EvolutionaryTrace 1 ExpressionAtlas 1 GO 32 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 14 PDBsum 12 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 REPRODUCTION-2DPAGE 3 RNAct 1 Reactome 3 RefSeq 5 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SWISS-2DPAGE 1 SignaLink 1 SwissPalm 1 TopDownProteomics 2 TreeFam 1 UCD-2DPAGE 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2557628

Title: Primary structures of the heterogeneous nuclear ribonucleoprotein A2, B1, and C2 proteins: a diversity of RNA binding proteins is generated by small peptide inserts.

PubMed ID: 2557628

DOI: 10.1073/pnas.86.24.9788

PubMed ID: 8029005

Title: Two homologous genes, originated by duplication, encode the human hnRNP proteins A2 and A1.

PubMed ID: 8029005

DOI: 10.1093/nar/22.11.1996

PubMed ID: 7789969

Title: Structure and expression of the gene (HNRPA2B1) encoding the human hnRNP protein A2/B1.

PubMed ID: 7789969

DOI: 10.1016/0888-7543(95)80035-k

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 1522214

Title: Purification and partial sequencing of the nuclear autoantigen RA33 shows that it is indistinguishable from the A2 protein of the heterogeneous nuclear ribonucleoprotein complex.

PubMed ID: 1522214

DOI: 10.1172/jci115921

PubMed ID: 7980541

Title: ADP-ribosylation of heterogeneous ribonucleoproteins in HeLa cells.

PubMed ID: 7980541

DOI: 10.1006/bbrc.1994.2526

PubMed ID: 3733753

Title: Purification and domain structure of core hnRNP proteins A1 and A2 and their relationship to single-stranded DNA-binding proteins.

PubMed ID: 3733753

DOI: 10.1016/s0021-9258(18)67378-8

PubMed ID: 1699755

Title: Two-dimensional gel electrophoresis, protein electroblotting and microsequencing: a direct link between proteins and genes.

PubMed ID: 1699755

DOI: 10.1002/elps.1150110703

PubMed ID: 10567417

Title: Mutational analysis of a heterogeneous nuclear ribonucleoprotein A2 response element for RNA trafficking.

PubMed ID: 10567417

DOI: 10.1074/jbc.274.48.34389

PubMed ID: 10772824

Title: The RGG domain in hnRNP A2 affects subcellular localization.

PubMed ID: 10772824

DOI: 10.1006/excr.2000.4827

PubMed ID: 11991638

Title: Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.

PubMed ID: 11991638

DOI: 10.1017/s1355838202021088

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 15294897

Title: A late role for the association of hnRNP A2 with the HIV-1 hnRNP A2 response elements in genomic RNA, Gag, and Vpr localization.

PubMed ID: 15294897

DOI: 10.1074/jbc.m404691200

PubMed ID: 15782174

Title: Identifying and quantifying in vivo methylation sites by heavy methyl SILAC.

PubMed ID: 15782174

DOI: 10.1038/nmeth715

PubMed ID: 15703215

Title: The microtubule-associated protein tumor overexpressed gene binds to the RNA trafficking protein heterogeneous nuclear ribonucleoprotein A2.

PubMed ID: 15703215

DOI: 10.1091/mbc.e04-08-0709

PubMed ID: 17004321

Title: Trafficking of HIV-1 RNA is mediated by heterogeneous nuclear ribonucleoprotein A2 expression and impacts on viral assembly.

PubMed ID: 17004321

DOI: 10.1111/j.1600-0854.2006.00461.x

PubMed ID: 17924679

Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

PubMed ID: 17924679

DOI: 10.1021/pr070152u

PubMed ID: 17289661

Title: Molecular composition of IMP1 ribonucleoprotein granules.

PubMed ID: 17289661

DOI: 10.1074/mcp.m600346-mcp200

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19099192

Title: Nuclear functions of heterogeneous nuclear ribonucleoproteins A/B.

PubMed ID: 19099192

DOI: 10.1007/s00018-008-8532-1

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19429692

Title: Functional mapping of the interaction between TDP-43 and hnRNP A2 in vivo.

PubMed ID: 19429692

DOI: 10.1093/nar/gkp342

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20010808

Title: HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer.

PubMed ID: 20010808

DOI: 10.1038/nature08697

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22905912

Title: Resveratrol-induced changes of the human adipocyte secretion profile.

PubMed ID: 22905912

DOI: 10.1021/pr300539b

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24356509

Title: Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs.

PubMed ID: 24356509

DOI: 10.1038/ncomms3980

PubMed ID: 24098712

Title: Arginine methylation of hnRNP A2 does not directly govern its subcellular localization.

PubMed ID: 24098712

DOI: 10.1371/journal.pone.0075669

PubMed ID: 24549040

Title: C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking.

PubMed ID: 24549040

DOI: 10.1093/hmg/ddu068

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25678563

Title: Peptidylprolyl isomerase A governs TARDBP function and assembly in heterogeneous nuclear ribonucleoprotein complexes.

PubMed ID: 25678563

DOI: 10.1093/brain/awv005

PubMed ID: 26544936

Title: The LC domain of hnRNPA2 adopts similar conformations in hydrogel polymers, liquid-like droplets, and nuclei.

PubMed ID: 26544936

DOI: 10.1016/j.cell.2015.10.040

PubMed ID: 26321680

Title: HNRNPA2B1 is a mediator of m(6)A-dependent nuclear RNA processing events.

PubMed ID: 26321680

DOI: 10.1016/j.cell.2015.08.011

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 31320558

Title: Nuclear hnRNPA2B1 initiates and amplifies the innate immune response to DNA viruses.

PubMed ID: 31320558

DOI: 10.1126/science.aav0758

PubMed ID: 23455423

Title: Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS.

PubMed ID: 23455423

DOI: 10.1038/nature11922

Sequence Information:

  • Length: 353
  • Mass: 37430
  • Checksum: 4C2560A3D8E99D62
  • Sequence:
    • MEKTLETVPL ERKKREKEQF RKLFIGGLSF ETTEESLRNY YEQWGKLTDC VVMRDPASKR 
SRGFGFVTFS SMAEVDAAMA ARPHSIDGRV VEPKRAVARE ESGKPGAHVT VKKLFVGGIK 
EDTEEHHLRD YFEEYGKIDT IEIITDRQSG KKRGFGFVTF DDHDPVDKIV LQKYHTINGH 
NAEVRKALSR QEMQEVQSSR SGRGGNFGFG DSRGGGGNFG PGPGSNFRGG SDGYGSGRGF 
GDGYNGYGGG PGGGNFGGSP GYGGGRGGYG GGGPGYGNQG GGYGGGYDNY GGGNYGSGNY 
NDFGNYNQQP SNYGPMKSGN FGGSRNMGGP YGGGNYGPGG SGGSGGYGGR SRY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.