Details for: HNRNPA2B1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 1200.7119
Cell Significance Index: -186.7700 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 763.3158
Cell Significance Index: -193.6100 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 575.0246
Cell Significance Index: -236.8800 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 505.6101
Cell Significance Index: -238.7100 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 504.6681
Cell Significance Index: -205.0300 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 447.2912
Cell Significance Index: -230.0800 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 356.9778
Cell Significance Index: -239.5400 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 217.3412
Cell Significance Index: -207.5100 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 180.8317
Cell Significance Index: -222.9600 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 60.3522
Cell Significance Index: -161.6800 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 59.6546
Cell Significance Index: -235.4000 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 54.1372
Cell Significance Index: -166.2800 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 35.5480
Cell Significance Index: -77.8000 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 5.0407
Cell Significance Index: 236.9100 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 4.9085
Cell Significance Index: 170.5700 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 4.8339
Cell Significance Index: 663.8300 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 4.8160
Cell Significance Index: 567.9600 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 4.8053
Cell Significance Index: 310.0200 - Cell Name: granulosa cell (CL0000501)
Fold Change: 4.7439
Cell Significance Index: 124.7400 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 4.6301
Cell Significance Index: 241.1800 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 4.5275
Cell Significance Index: 120.8900 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 4.2560
Cell Significance Index: 523.3100 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 4.2315
Cell Significance Index: 762.8100 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 4.2187
Cell Significance Index: 114.8300 - Cell Name: odontoblast (CL0000060)
Fold Change: 3.8822
Cell Significance Index: 497.6700 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 3.5443
Cell Significance Index: 186.0900 - Cell Name: cell in vitro (CL0001034)
Fold Change: 3.3378
Cell Significance Index: 1822.8700 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 3.1311
Cell Significance Index: 65.5400 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 3.0869
Cell Significance Index: 1364.8100 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 2.9468
Cell Significance Index: 165.3600 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 2.6506
Cell Significance Index: 526.0200 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 2.5510
Cell Significance Index: 73.1300 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 2.3812
Cell Significance Index: 107.9300 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.9546
Cell Significance Index: 392.1000 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 1.8292
Cell Significance Index: 20.7800 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.8168
Cell Significance Index: 84.7100 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.7287
Cell Significance Index: 128.8400 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 1.6792
Cell Significance Index: 118.7600 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.6354
Cell Significance Index: 586.6000 - Cell Name: lactocyte (CL0002325)
Fold Change: 1.6163
Cell Significance Index: 208.8100 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.2932
Cell Significance Index: 36.1400 - Cell Name: peg cell (CL4033014)
Fold Change: 1.2847
Cell Significance Index: 29.6800 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.2564
Cell Significance Index: 36.2000 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 1.2139
Cell Significance Index: 74.6100 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.9980
Cell Significance Index: 29.3100 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.9716
Cell Significance Index: 671.9900 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.6070
Cell Significance Index: 46.5800 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.5546
Cell Significance Index: 94.7000 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.5389
Cell Significance Index: 9.9600 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 0.4332
Cell Significance Index: 4.7100 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.3744
Cell Significance Index: 19.4500 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.3720
Cell Significance Index: 700.3800 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.3380
Cell Significance Index: 214.7000 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.2791
Cell Significance Index: 204.6000 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.2373
Cell Significance Index: 365.3900 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.1782
Cell Significance Index: 328.7300 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.1715
Cell Significance Index: 129.8500 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.1604
Cell Significance Index: 144.8100 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0251
Cell Significance Index: 34.0800 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0015
Cell Significance Index: -0.0200 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0220
Cell Significance Index: -9.9800 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.1210
Cell Significance Index: -89.6400 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.1368
Cell Significance Index: -85.4500 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1385
Cell Significance Index: -14.1500 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: -0.1650
Cell Significance Index: -26.8300 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: -0.2443
Cell Significance Index: -26.5700 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.3192
Cell Significance Index: -180.0000 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: -0.3613
Cell Significance Index: -68.7600 - Cell Name: colon goblet cell (CL0009039)
Fold Change: -0.3930
Cell Significance Index: -38.8800 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.4992
Cell Significance Index: -31.4700 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.5475
Cell Significance Index: -115.3200 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.6090
Cell Significance Index: -88.5200 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.6775
Cell Significance Index: -194.9500 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -1.0435
Cell Significance Index: -119.1200 - Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: -1.1631
Cell Significance Index: -8.9700 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -1.4264
Cell Significance Index: -163.4200 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -1.4511
Cell Significance Index: -97.5700 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -1.4543
Cell Significance Index: -169.4800 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -1.6708
Cell Significance Index: -58.7100 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -1.7395
Cell Significance Index: -30.7400 - Cell Name: preadipocyte (CL0002334)
Fold Change: -1.7605
Cell Significance Index: -34.3600 - Cell Name: pro-T cell (CL0000827)
Fold Change: -1.7677
Cell Significance Index: -45.1600 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -1.9304
Cell Significance Index: -152.8900 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -1.9615
Cell Significance Index: -204.2400 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -1.9738
Cell Significance Index: -26.9300 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -1.9885
Cell Significance Index: -63.6900 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -2.3874
Cell Significance Index: -30.5800 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -2.6276
Cell Significance Index: -45.0300 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -2.7409
Cell Significance Index: -41.0700 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -2.8100
Cell Significance Index: -75.1700 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -2.8632
Cell Significance Index: -62.0300 - Cell Name: kidney cell (CL1000497)
Fold Change: -2.9107
Cell Significance Index: -23.2400 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -3.3062
Cell Significance Index: -146.2400 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -3.6966
Cell Significance Index: -95.0200 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -3.8230
Cell Significance Index: -35.2100 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -3.8378
Cell Significance Index: -235.2900 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -3.9612
Cell Significance Index: -47.2200 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -4.0325
Cell Significance Index: -152.7000 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -4.0358
Cell Significance Index: -96.7900 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -4.2504
Cell Significance Index: -71.6000
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3733172738
Symbol: ROA2_HUMAN
Name: Heterogeneous nuclear ribonucleoproteins A2/B1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2557628
Title: Primary structures of the heterogeneous nuclear ribonucleoprotein A2, B1, and C2 proteins: a diversity of RNA binding proteins is generated by small peptide inserts.
PubMed ID: 2557628
PubMed ID: 8029005
Title: Two homologous genes, originated by duplication, encode the human hnRNP proteins A2 and A1.
PubMed ID: 8029005
PubMed ID: 7789969
Title: Structure and expression of the gene (HNRPA2B1) encoding the human hnRNP protein A2/B1.
PubMed ID: 7789969
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 1522214
Title: Purification and partial sequencing of the nuclear autoantigen RA33 shows that it is indistinguishable from the A2 protein of the heterogeneous nuclear ribonucleoprotein complex.
PubMed ID: 1522214
DOI: 10.1172/jci115921
PubMed ID: 7980541
Title: ADP-ribosylation of heterogeneous ribonucleoproteins in HeLa cells.
PubMed ID: 7980541
PubMed ID: 3733753
Title: Purification and domain structure of core hnRNP proteins A1 and A2 and their relationship to single-stranded DNA-binding proteins.
PubMed ID: 3733753
PubMed ID: 1699755
Title: Two-dimensional gel electrophoresis, protein electroblotting and microsequencing: a direct link between proteins and genes.
PubMed ID: 1699755
PubMed ID: 10567417
Title: Mutational analysis of a heterogeneous nuclear ribonucleoprotein A2 response element for RNA trafficking.
PubMed ID: 10567417
PubMed ID: 10772824
Title: The RGG domain in hnRNP A2 affects subcellular localization.
PubMed ID: 10772824
PubMed ID: 11991638
Title: Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.
PubMed ID: 11991638
PubMed ID: 14654843
Title: Proteomic characterization of the human centrosome by protein correlation profiling.
PubMed ID: 14654843
DOI: 10.1038/nature02166
PubMed ID: 15294897
Title: A late role for the association of hnRNP A2 with the HIV-1 hnRNP A2 response elements in genomic RNA, Gag, and Vpr localization.
PubMed ID: 15294897
PubMed ID: 15782174
Title: Identifying and quantifying in vivo methylation sites by heavy methyl SILAC.
PubMed ID: 15782174
DOI: 10.1038/nmeth715
PubMed ID: 15703215
Title: The microtubule-associated protein tumor overexpressed gene binds to the RNA trafficking protein heterogeneous nuclear ribonucleoprotein A2.
PubMed ID: 15703215
PubMed ID: 17004321
Title: Trafficking of HIV-1 RNA is mediated by heterogeneous nuclear ribonucleoprotein A2 expression and impacts on viral assembly.
PubMed ID: 17004321
PubMed ID: 17924679
Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.
PubMed ID: 17924679
DOI: 10.1021/pr070152u
PubMed ID: 17289661
Title: Molecular composition of IMP1 ribonucleoprotein granules.
PubMed ID: 17289661
PubMed ID: 18220336
Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.
PubMed ID: 18220336
DOI: 10.1021/pr0705441
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19099192
Title: Nuclear functions of heterogeneous nuclear ribonucleoproteins A/B.
PubMed ID: 19099192
PubMed ID: 19369195
Title: Large-scale proteomics analysis of the human kinome.
PubMed ID: 19369195
PubMed ID: 19429692
Title: Functional mapping of the interaction between TDP-43 and hnRNP A2 in vivo.
PubMed ID: 19429692
DOI: 10.1093/nar/gkp342
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 20010808
Title: HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer.
PubMed ID: 20010808
DOI: 10.1038/nature08697
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22905912
Title: Resveratrol-induced changes of the human adipocyte secretion profile.
PubMed ID: 22905912
DOI: 10.1021/pr300539b
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24356509
Title: Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs.
PubMed ID: 24356509
DOI: 10.1038/ncomms3980
PubMed ID: 24098712
Title: Arginine methylation of hnRNP A2 does not directly govern its subcellular localization.
PubMed ID: 24098712
PubMed ID: 24549040
Title: C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking.
PubMed ID: 24549040
DOI: 10.1093/hmg/ddu068
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 24129315
Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.
PubMed ID: 24129315
PubMed ID: 25218447
Title: Uncovering global SUMOylation signaling networks in a site-specific manner.
PubMed ID: 25218447
DOI: 10.1038/nsmb.2890
PubMed ID: 25678563
Title: Peptidylprolyl isomerase A governs TARDBP function and assembly in heterogeneous nuclear ribonucleoprotein complexes.
PubMed ID: 25678563
DOI: 10.1093/brain/awv005
PubMed ID: 26544936
Title: The LC domain of hnRNPA2 adopts similar conformations in hydrogel polymers, liquid-like droplets, and nuclei.
PubMed ID: 26544936
PubMed ID: 26321680
Title: HNRNPA2B1 is a mediator of m(6)A-dependent nuclear RNA processing events.
PubMed ID: 26321680
PubMed ID: 25755297
Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.
PubMed ID: 25755297
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 31320558
Title: Nuclear hnRNPA2B1 initiates and amplifies the innate immune response to DNA viruses.
PubMed ID: 31320558
PubMed ID: 23455423
Title: Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS.
PubMed ID: 23455423
DOI: 10.1038/nature11922
PubMed ID: 35484142
Title: Heterozygous frameshift variants in HNRNPA2B1 cause early-onset oculopharyngeal muscular dystrophy.
PubMed ID: 35484142
Sequence Information:
- Length: 353
- Mass: 37430
- Checksum: 4C2560A3D8E99D62
- Sequence:
MEKTLETVPL ERKKREKEQF RKLFIGGLSF ETTEESLRNY YEQWGKLTDC VVMRDPASKR SRGFGFVTFS SMAEVDAAMA ARPHSIDGRV VEPKRAVARE ESGKPGAHVT VKKLFVGGIK EDTEEHHLRD YFEEYGKIDT IEIITDRQSG KKRGFGFVTF DDHDPVDKIV LQKYHTINGH NAEVRKALSR QEMQEVQSSR SGRGGNFGFG DSRGGGGNFG PGPGSNFRGG SDGYGSGRGF GDGYNGYGGG PGGGNFGGSP GYGGGRGGYG GGGPGYGNQG GGYGGGYDNY GGGNYGSGNY NDFGNYNQQP SNYGPMKSGN FGGSRNMGGP YGGGNYGPGG SGGSGGYGGR SRY
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.