Details for: HNRNPA2B1

Gene ID: 3181

Symbol: HNRNPA2B1

Ensembl ID: ENSG00000122566

Description: heterogeneous nuclear ribonucleoprotein A2/B1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 1200.7119
    Cell Significance Index: -186.7700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 763.3158
    Cell Significance Index: -193.6100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 575.0246
    Cell Significance Index: -236.8800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 505.6101
    Cell Significance Index: -238.7100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 504.6681
    Cell Significance Index: -205.0300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 447.2912
    Cell Significance Index: -230.0800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 356.9778
    Cell Significance Index: -239.5400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 217.3412
    Cell Significance Index: -207.5100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 180.8317
    Cell Significance Index: -222.9600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 60.3522
    Cell Significance Index: -161.6800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 59.6546
    Cell Significance Index: -235.4000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 54.1372
    Cell Significance Index: -166.2800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 35.5480
    Cell Significance Index: -77.8000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 5.0407
    Cell Significance Index: 236.9100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 4.9085
    Cell Significance Index: 170.5700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 4.8339
    Cell Significance Index: 663.8300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 4.8160
    Cell Significance Index: 567.9600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 4.8053
    Cell Significance Index: 310.0200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 4.7439
    Cell Significance Index: 124.7400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 4.6301
    Cell Significance Index: 241.1800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 4.5275
    Cell Significance Index: 120.8900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 4.2560
    Cell Significance Index: 523.3100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 4.2315
    Cell Significance Index: 762.8100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.2187
    Cell Significance Index: 114.8300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 3.8822
    Cell Significance Index: 497.6700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.5443
    Cell Significance Index: 186.0900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.3378
    Cell Significance Index: 1822.8700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 3.1311
    Cell Significance Index: 65.5400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 3.0869
    Cell Significance Index: 1364.8100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.9468
    Cell Significance Index: 165.3600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.6506
    Cell Significance Index: 526.0200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.5510
    Cell Significance Index: 73.1300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.3812
    Cell Significance Index: 107.9300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.9546
    Cell Significance Index: 392.1000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.8292
    Cell Significance Index: 20.7800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.8168
    Cell Significance Index: 84.7100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.7287
    Cell Significance Index: 128.8400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.6792
    Cell Significance Index: 118.7600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.6354
    Cell Significance Index: 586.6000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.6163
    Cell Significance Index: 208.8100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.2932
    Cell Significance Index: 36.1400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.2847
    Cell Significance Index: 29.6800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.2564
    Cell Significance Index: 36.2000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.2139
    Cell Significance Index: 74.6100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.9980
    Cell Significance Index: 29.3100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.9716
    Cell Significance Index: 671.9900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.6070
    Cell Significance Index: 46.5800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.5546
    Cell Significance Index: 94.7000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.5389
    Cell Significance Index: 9.9600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.4332
    Cell Significance Index: 4.7100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3744
    Cell Significance Index: 19.4500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.3720
    Cell Significance Index: 700.3800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.3380
    Cell Significance Index: 214.7000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.2791
    Cell Significance Index: 204.6000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.2373
    Cell Significance Index: 365.3900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1782
    Cell Significance Index: 328.7300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1715
    Cell Significance Index: 129.8500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1604
    Cell Significance Index: 144.8100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0251
    Cell Significance Index: 34.0800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0015
    Cell Significance Index: -0.0200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0220
    Cell Significance Index: -9.9800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1210
    Cell Significance Index: -89.6400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1368
    Cell Significance Index: -85.4500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1385
    Cell Significance Index: -14.1500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.1650
    Cell Significance Index: -26.8300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.2443
    Cell Significance Index: -26.5700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.3192
    Cell Significance Index: -180.0000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.3613
    Cell Significance Index: -68.7600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.3930
    Cell Significance Index: -38.8800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4992
    Cell Significance Index: -31.4700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.5475
    Cell Significance Index: -115.3200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.6090
    Cell Significance Index: -88.5200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.6775
    Cell Significance Index: -194.9500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -1.0435
    Cell Significance Index: -119.1200
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -1.1631
    Cell Significance Index: -8.9700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -1.4264
    Cell Significance Index: -163.4200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.4511
    Cell Significance Index: -97.5700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -1.4543
    Cell Significance Index: -169.4800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -1.6708
    Cell Significance Index: -58.7100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -1.7395
    Cell Significance Index: -30.7400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -1.7605
    Cell Significance Index: -34.3600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -1.7677
    Cell Significance Index: -45.1600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.9304
    Cell Significance Index: -152.8900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.9615
    Cell Significance Index: -204.2400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.9738
    Cell Significance Index: -26.9300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.9885
    Cell Significance Index: -63.6900
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -2.3874
    Cell Significance Index: -30.5800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -2.6276
    Cell Significance Index: -45.0300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -2.7409
    Cell Significance Index: -41.0700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -2.8100
    Cell Significance Index: -75.1700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -2.8632
    Cell Significance Index: -62.0300
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -2.9107
    Cell Significance Index: -23.2400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -3.3062
    Cell Significance Index: -146.2400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -3.6966
    Cell Significance Index: -95.0200
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -3.8230
    Cell Significance Index: -35.2100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -3.8378
    Cell Significance Index: -235.2900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -3.9612
    Cell Significance Index: -47.2200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -4.0325
    Cell Significance Index: -152.7000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -4.0358
    Cell Significance Index: -96.7900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -4.2504
    Cell Significance Index: -71.6000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Multifunctional protein**: HNRNPA2B1 is a member of the heterogeneous nuclear ribonucleoprotein (hnRNP) family, which plays a crucial role in RNA processing, transport, and storage. 2. **RNA binding**: The protein exhibits high affinity for RNA, particularly 3'-UTR (untranslated region) regions, and is involved in mRNA export, processing, and splicing. 3. **Regulation of immune responses**: HNRNPA2B1 is significantly expressed in immune cells, including T cells, B cells, and dendritic cells, where it influences cytokine signaling, immune cell activation, and regulation of immune responses. **Pathways and Functions:** 1. **RNA splicing and processing**: HNRNPA2B1 is essential for the regulation of alternative splicing, which is critical for the generation of diverse protein isoforms. It interacts with spliceosomal components and regulates the processing of pre-mRNA. 2. **Cytokine signaling**: HNRNPA2B1 modulates the activity of cytokines, such as IL-12, which is crucial for the development and maintenance of adaptive immune responses. 3. **Telomere maintenance**: The protein is involved in the regulation of telomerase activity and telomere lengthening, which is essential for the maintenance of genome stability and cellular longevity. 4. **Gene expression regulation**: HNRNPA2B1 influences the expression of genes involved in immune responses, including cytokines, chemokines, and adhesion molecules. 5. **MicroRNA binding and transport**: The protein interacts with microRNAs (miRNAs) and regulates their processing, transport, and activity, which is critical for the regulation of gene expression. **Clinical Significance:** 1. **Autoimmune diseases**: HNRNPA2B1 dysregulation has been implicated in autoimmune diseases, such as multiple sclerosis, rheumatoid arthritis, and lupus, where it influences cytokine signaling and immune cell activation. 2. **Cancer**: The protein is overexpressed in various types of cancer, including lymphomas, leukemias, and solid tumors, where it regulates gene expression, cell proliferation, and survival. 3. **Neurological disorders**: HNRNPA2B1 is involved in the regulation of gene expression in the nervous system, and its dysregulation has been implicated in neurological disorders, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. 4. **Infectious diseases**: The protein regulates cytokine signaling and immune responses in the context of infectious diseases, such as HIV, tuberculosis, and malaria. In conclusion, HNRNPA2B1 is a multifunctional protein that plays a critical role in immune regulation, telomere maintenance, and gene expression. Its dysregulation has been implicated in various diseases, highlighting the importance of this gene in maintaining cellular homeostasis and preventing disease. Further research is necessary to elucidate the complex functions of HNRNPA2B1 and its potential therapeutic applications.

Genular Protein ID: 3733172738

Symbol: ROA2_HUMAN

Name: Heterogeneous nuclear ribonucleoproteins A2/B1

UniProtKB Accession Codes:

P22626 A0A024RA27 A0A024RA61 A8K064 P22627 Q9UC98 Q9UDJ2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 2 EMBL 13 EMDB 4 Ensembl 32 EvolutionaryTrace 1 ExpressionAtlas 1 GO 32 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 13 PDBsum 13 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 REPRODUCTION-2DPAGE 3 RNAct 1 Reactome 3 RefSeq 5 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 2 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2557628

Title: Primary structures of the heterogeneous nuclear ribonucleoprotein A2, B1, and C2 proteins: a diversity of RNA binding proteins is generated by small peptide inserts.

PubMed ID: 2557628

DOI: 10.1073/pnas.86.24.9788

PubMed ID: 8029005

Title: Two homologous genes, originated by duplication, encode the human hnRNP proteins A2 and A1.

PubMed ID: 8029005

DOI: 10.1093/nar/22.11.1996

PubMed ID: 7789969

Title: Structure and expression of the gene (HNRPA2B1) encoding the human hnRNP protein A2/B1.

PubMed ID: 7789969

DOI: 10.1016/0888-7543(95)80035-k

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 1522214

Title: Purification and partial sequencing of the nuclear autoantigen RA33 shows that it is indistinguishable from the A2 protein of the heterogeneous nuclear ribonucleoprotein complex.

PubMed ID: 1522214

DOI: 10.1172/jci115921

PubMed ID: 7980541

Title: ADP-ribosylation of heterogeneous ribonucleoproteins in HeLa cells.

PubMed ID: 7980541

DOI: 10.1006/bbrc.1994.2526

PubMed ID: 3733753

Title: Purification and domain structure of core hnRNP proteins A1 and A2 and their relationship to single-stranded DNA-binding proteins.

PubMed ID: 3733753

DOI: 10.1016/s0021-9258(18)67378-8

PubMed ID: 1699755

Title: Two-dimensional gel electrophoresis, protein electroblotting and microsequencing: a direct link between proteins and genes.

PubMed ID: 1699755

DOI: 10.1002/elps.1150110703

PubMed ID: 10567417

Title: Mutational analysis of a heterogeneous nuclear ribonucleoprotein A2 response element for RNA trafficking.

PubMed ID: 10567417

DOI: 10.1074/jbc.274.48.34389

PubMed ID: 10772824

Title: The RGG domain in hnRNP A2 affects subcellular localization.

PubMed ID: 10772824

DOI: 10.1006/excr.2000.4827

PubMed ID: 11991638

Title: Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.

PubMed ID: 11991638

DOI: 10.1017/s1355838202021088

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 15294897

Title: A late role for the association of hnRNP A2 with the HIV-1 hnRNP A2 response elements in genomic RNA, Gag, and Vpr localization.

PubMed ID: 15294897

DOI: 10.1074/jbc.m404691200

PubMed ID: 15782174

Title: Identifying and quantifying in vivo methylation sites by heavy methyl SILAC.

PubMed ID: 15782174

DOI: 10.1038/nmeth715

PubMed ID: 15703215

Title: The microtubule-associated protein tumor overexpressed gene binds to the RNA trafficking protein heterogeneous nuclear ribonucleoprotein A2.

PubMed ID: 15703215

DOI: 10.1091/mbc.e04-08-0709

PubMed ID: 17004321

Title: Trafficking of HIV-1 RNA is mediated by heterogeneous nuclear ribonucleoprotein A2 expression and impacts on viral assembly.

PubMed ID: 17004321

DOI: 10.1111/j.1600-0854.2006.00461.x

PubMed ID: 17924679

Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

PubMed ID: 17924679

DOI: 10.1021/pr070152u

PubMed ID: 17289661

Title: Molecular composition of IMP1 ribonucleoprotein granules.

PubMed ID: 17289661

DOI: 10.1074/mcp.m600346-mcp200

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19099192

Title: Nuclear functions of heterogeneous nuclear ribonucleoproteins A/B.

PubMed ID: 19099192

DOI: 10.1007/s00018-008-8532-1

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19429692

Title: Functional mapping of the interaction between TDP-43 and hnRNP A2 in vivo.

PubMed ID: 19429692

DOI: 10.1093/nar/gkp342

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20010808

Title: HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer.

PubMed ID: 20010808

DOI: 10.1038/nature08697

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22905912

Title: Resveratrol-induced changes of the human adipocyte secretion profile.

PubMed ID: 22905912

DOI: 10.1021/pr300539b

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24356509

Title: Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs.

PubMed ID: 24356509

DOI: 10.1038/ncomms3980

PubMed ID: 24098712

Title: Arginine methylation of hnRNP A2 does not directly govern its subcellular localization.

PubMed ID: 24098712

DOI: 10.1371/journal.pone.0075669

PubMed ID: 24549040

Title: C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking.

PubMed ID: 24549040

DOI: 10.1093/hmg/ddu068

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25678563

Title: Peptidylprolyl isomerase A governs TARDBP function and assembly in heterogeneous nuclear ribonucleoprotein complexes.

PubMed ID: 25678563

DOI: 10.1093/brain/awv005

PubMed ID: 26544936

Title: The LC domain of hnRNPA2 adopts similar conformations in hydrogel polymers, liquid-like droplets, and nuclei.

PubMed ID: 26544936

DOI: 10.1016/j.cell.2015.10.040

PubMed ID: 26321680

Title: HNRNPA2B1 is a mediator of m(6)A-dependent nuclear RNA processing events.

PubMed ID: 26321680

DOI: 10.1016/j.cell.2015.08.011

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 31320558

Title: Nuclear hnRNPA2B1 initiates and amplifies the innate immune response to DNA viruses.

PubMed ID: 31320558

DOI: 10.1126/science.aav0758

PubMed ID: 23455423

Title: Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS.

PubMed ID: 23455423

DOI: 10.1038/nature11922

PubMed ID: 35484142

Title: Heterozygous frameshift variants in HNRNPA2B1 cause early-onset oculopharyngeal muscular dystrophy.

PubMed ID: 35484142

DOI: 10.1038/s41467-022-30015-1

Sequence Information:

  • Length: 353
  • Mass: 37430
  • Checksum: 4C2560A3D8E99D62
  • Sequence:
    • MEKTLETVPL ERKKREKEQF RKLFIGGLSF ETTEESLRNY YEQWGKLTDC VVMRDPASKR 
SRGFGFVTFS SMAEVDAAMA ARPHSIDGRV VEPKRAVARE ESGKPGAHVT VKKLFVGGIK 
EDTEEHHLRD YFEEYGKIDT IEIITDRQSG KKRGFGFVTF DDHDPVDKIV LQKYHTINGH 
NAEVRKALSR QEMQEVQSSR SGRGGNFGFG DSRGGGGNFG PGPGSNFRGG SDGYGSGRGF 
GDGYNGYGGG PGGGNFGGSP GYGGGRGGYG GGGPGYGNQG GGYGGGYDNY GGGNYGSGNY 
NDFGNYNQQP SNYGPMKSGN FGGSRNMGGP YGGGNYGPGG SGGSGGYGGR SRY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.