Details for: B3GALT1

Gene ID: 8708

Symbol: B3GALT1

Ensembl ID: ENSG00000172318

Description: beta-1,3-galactosyltransferase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 3.1351
    Cell Significance Index: 2168.3400
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 2.7539
    Cell Significance Index: 45.3800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.0076
    Cell Significance Index: 43.9600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.8940
    Cell Significance Index: 40.4900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.3924
    Cell Significance Index: 30.1700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.0933
    Cell Significance Index: 27.3300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.6696
    Cell Significance Index: 41.0600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.6690
    Cell Significance Index: 17.2000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4932
    Cell Significance Index: 176.9000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3268
    Cell Significance Index: 62.2000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1912
    Cell Significance Index: 8.6700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1734
    Cell Significance Index: 34.7900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1712
    Cell Significance Index: 8.9900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1706
    Cell Significance Index: 16.8800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1620
    Cell Significance Index: 3.4500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.1175
    Cell Significance Index: 2.8500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1084
    Cell Significance Index: 6.5100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1044
    Cell Significance Index: 94.2700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1030
    Cell Significance Index: 16.7600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0817
    Cell Significance Index: 8.8900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.0697
    Cell Significance Index: 1.7000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0440
    Cell Significance Index: 2.9600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0204
    Cell Significance Index: 2.6200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0163
    Cell Significance Index: 3.2300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0147
    Cell Significance Index: 8.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0020
    Cell Significance Index: 3.6900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0027
    Cell Significance Index: -0.7800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0051
    Cell Significance Index: -9.4100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0062
    Cell Significance Index: -9.5600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0062
    Cell Significance Index: -8.4400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0102
    Cell Significance Index: -0.3600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0103
    Cell Significance Index: -4.5600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0152
    Cell Significance Index: -11.2900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0152
    Cell Significance Index: -9.5000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0158
    Cell Significance Index: -1.0900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0200
    Cell Significance Index: -12.7200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0203
    Cell Significance Index: -15.3900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0204
    Cell Significance Index: -11.5000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0215
    Cell Significance Index: -0.6200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0277
    Cell Significance Index: -12.5900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0333
    Cell Significance Index: -0.7200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0364
    Cell Significance Index: -0.8400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0405
    Cell Significance Index: -0.7000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0487
    Cell Significance Index: -8.3200
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0504
    Cell Significance Index: -0.6600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0574
    Cell Significance Index: -12.0800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0586
    Cell Significance Index: -8.0500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0613
    Cell Significance Index: -7.0200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0697
    Cell Significance Index: -1.9900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0731
    Cell Significance Index: -13.1700
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0819
    Cell Significance Index: -1.7100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0841
    Cell Significance Index: -12.2200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0896
    Cell Significance Index: -2.8700
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.0905
    Cell Significance Index: -1.4600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0927
    Cell Significance Index: -5.2000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0950
    Cell Significance Index: -1.9700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1003
    Cell Significance Index: -3.2000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1010
    Cell Significance Index: -6.2100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1032
    Cell Significance Index: -2.1900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1059
    Cell Significance Index: -12.3500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1081
    Cell Significance Index: -13.2900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1112
    Cell Significance Index: -11.5800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1128
    Cell Significance Index: -4.9900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1145
    Cell Significance Index: -3.7500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1150
    Cell Significance Index: -5.3600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1158
    Cell Significance Index: -8.8900
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1197
    Cell Significance Index: -1.1400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1200
    Cell Significance Index: -15.5000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1340
    Cell Significance Index: -2.6500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1399
    Cell Significance Index: -3.4900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1399
    Cell Significance Index: -8.8200
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.1440
    Cell Significance Index: -1.6800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1500
    Cell Significance Index: -3.1400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1526
    Cell Significance Index: -5.7800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1579
    Cell Significance Index: -5.5300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1607
    Cell Significance Index: -16.4200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1828
    Cell Significance Index: -3.6700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2060
    Cell Significance Index: -4.9400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2084
    Cell Significance Index: -7.6500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2089
    Cell Significance Index: -15.5700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2201
    Cell Significance Index: -5.9900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2472
    Cell Significance Index: -10.7500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.2523
    Cell Significance Index: -1.7100
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.2577
    Cell Significance Index: -2.1300
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.2708
    Cell Significance Index: -5.3300
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: -0.2805
    Cell Significance Index: -2.6700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2816
    Cell Significance Index: -14.6700
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.2848
    Cell Significance Index: -5.6800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2870
    Cell Significance Index: -3.1200
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.2899
    Cell Significance Index: -3.9700
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.3005
    Cell Significance Index: -4.2800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3172
    Cell Significance Index: -4.7800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3265
    Cell Significance Index: -15.3500
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: -0.3426
    Cell Significance Index: -3.7400
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.3504
    Cell Significance Index: -3.8700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.3571
    Cell Significance Index: -3.8900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.3607
    Cell Significance Index: -9.0100
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.3677
    Cell Significance Index: -4.6400
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.3696
    Cell Significance Index: -5.9300
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.3810
    Cell Significance Index: -4.3600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** B3GALT1 is a type II transmembrane glycoprotein, with a molecular weight of approximately 150 kDa. It exhibits a high degree of specificity for its substrates, including UDP-galactose and N-acetylglucosamine. The enzyme is activated by calcium ions and exhibits a pH-dependent activity. B3GALT1 is also known to be involved in the biosynthesis of various glycosphingolipids, such as galactosylceramide, which are essential for cellular signaling and membrane structure. **Pathways and Functions** B3GALT1 is involved in several key biological pathways, including: 1. **Blood Group Systems Biosynthesis**: B3GALT1 is essential for the production of ABO blood group antigens, which are determined by the presence or absence of specific carbohydrate structures on red blood cells. 2. **Galactosylceramide Biosynthetic Process**: B3GALT1 is involved in the production of galactosylceramide, a glycosphingolipid that plays a crucial role in cellular signaling and membrane structure. 3. **Golgi Membrane**: B3GALT1 is localized to the Golgi apparatus, where it is activated by calcium ions and catalyzes the transfer of galactose residues to growing carbohydrate chains. 4. **Lipid Glycosylation**: B3GALT1 is involved in the glycosylation of lipids, such as galactosylceramide, which is essential for cellular signaling and membrane structure. **Clinical Significance** Alterations in B3GALT1 expression or function have been implicated in various diseases, including: 1. **Blood Group Disorders**: Abnormalities in B3GALT1 expression or function can lead to blood group disorders, such as hemolytic disease of the newborn. 2. **Neurological Disorders**: B3GALT1 has been implicated in the pathogenesis of neurological disorders, such as Alzheimer's disease and Parkinson's disease, where abnormalities in glycosphingolipid metabolism have been observed. 3. **Cancer**: B3GALT1 has been found to be overexpressed in certain types of cancer, such as colon cancer, where it may play a role in tumor progression and metastasis. In conclusion, B3GALT1 is an essential enzyme involved in the biosynthesis of glycosphingolipids and glycoproteins, playing a crucial role in various cellular processes. Alterations in B3GALT1 expression or function have been implicated in various diseases, highlighting the importance of this gene in human health and disease.

Genular Protein ID: 3103792507

Symbol: B3GT1_HUMAN

Name: UDP-galactose:beta-N-acetyl-glucosamine-beta-1,3-galactosyltransferase 1

UniProtKB Accession Codes:

Q9Y5Z6 D3DPB8 Q53SS2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 1 CCDS 1 CTD 1 ChEBI 11 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 6 Ensembl 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 4 Rhea 4 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SwissLipids 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 10356986

Title: Differential expression of beta1,3galactosyltransferases in human colon cells derived from adenocarcinomas or normal mucosa.

PubMed ID: 10356986

DOI: 10.1016/s0014-5793(99)00547-5

PubMed ID: 15014171

Title: Human-specific amino acid changes found in 103 protein-coding genes.

PubMed ID: 15014171

DOI: 10.1093/molbev/msh100

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9582303

Title: A family of human beta3-galactosyltransferases. Characterization of four members of a UDP-galactose:beta-N-acetyl-glucosamine/beta-N-acetyl-galactosamine beta-1,3-galactosyltransferase family.

PubMed ID: 9582303

DOI: 10.1074/jbc.273.21.12770

Sequence Information:

  • Length: 326
  • Mass: 37993
  • Checksum: 83271E99B2EE74F5
  • Sequence:
    • MASKVSCLYV LTVVCWASAL WYLSITRPTS SYTGSKPFSH LTVARKNFTF GNIRTRPINP 
HSFEFLINEP NKCEKNIPFL VILISTTHKE FDARQAIRET WGDENNFKGI KIATLFLLGK 
NADPVLNQMV EQESQIFHDI IVEDFIDSYH NLTLKTLMGM RWVATFCSKA KYVMKTDSDI 
FVNMDNLIYK LLKPSTKPRR RYFTGYVING GPIRDVRSKW YMPRDLYPDS NYPPFCSGTG 
YIFSADVAEL IYKTSLHTRL LHLEDVYVGL CLRKLGIHPF QNSGFNHWKM AYSLCRYRRV 
ITVHQISPEE MHRIWNDMSS KKHLRC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.