PSMB1 | ENSG00000008018 | NCBI 5689

Details for: PSMB1

Gene ID: 5689

Symbol: PSMB1

Ensembl ID: ENSG00000008018

Description: proteasome 20S subunit beta 1

Associated with

Abc-family proteins mediated transport
(R-HSA-382556)
Abc transporter disorders
(R-HSA-5619084)
Adaptive immune system
(R-HSA-1280218)
Antigen processing-cross presentation
(R-HSA-1236975)
Apc/c-mediated degradation of cell cycle proteins
(R-HSA-174143)
Apoptosis
(R-HSA-109581)
Assembly of the pre-replicative complex
(R-HSA-68867)
Auf1 (hnrnp d0) binds and destabilizes mrna
(R-HSA-450408)
Axon guidance
(R-HSA-422475)
Beta-catenin independent wnt signaling
(R-HSA-3858494)
C-type lectin receptors (clrs)
(R-HSA-5621481)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to chemical stress
(R-HSA-9711123)
Cellular response to hypoxia
(R-HSA-1234174)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Clec7a (dectin-1) signaling
(R-HSA-5607764)
Cytokine signaling in immune system
(R-HSA-1280215)
Defective cftr causes cystic fibrosis
(R-HSA-5678895)
Degradation of axin
(R-HSA-4641257)
Degradation of beta-catenin by the destruction complex
(R-HSA-195253)
Degradation of dvl
(R-HSA-4641258)
Degradation of gli1 by the proteasome
(R-HSA-5610780)
Degradation of gli2 by the proteasome
(R-HSA-5610783)
Deubiquitination
(R-HSA-5688426)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Disorders of transmembrane transporters
(R-HSA-5619115)
Dna replication
(R-HSA-69306)
Dna replication pre-initiation
(R-HSA-69002)
Downstream signaling events of b cell receptor (bcr)
(R-HSA-1168372)
Downstream tcr signaling
(R-HSA-202424)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated nf-kb activation
(R-HSA-2871837)
Formation of paraxial mesoderm
(R-HSA-9793380)
G1/s dna damage checkpoints
(R-HSA-69615)
G2/m checkpoints
(R-HSA-69481)
Gastrulation
(R-HSA-9758941)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gli3 is processed to gli3r by the proteasome
(R-HSA-5610785)
Hedgehog 'off' state
(R-HSA-5610787)
Hedgehog 'on' state
(R-HSA-5632684)
Hedgehog ligand biogenesis
(R-HSA-5358346)
Hh mutants abrogate ligand secretion
(R-HSA-5387390)
Hh mutants are degraded by erad
(R-HSA-5362768)
Hiv infection
(R-HSA-162906)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Interleukin-1 family signaling
(R-HSA-446652)
Intracellular signaling by second messengers
(R-HSA-9006925)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk6/mapk4 signaling
(R-HSA-5687128)
Mapk family signaling cascades
(R-HSA-5683057)
Metabolism
(R-HSA-1430728)
Metabolism of amino acids and derivatives
(R-HSA-71291)
Metabolism of polyamines
(R-HSA-351202)
Metabolism of proteins
(R-HSA-392499)
Metabolism of rna
(R-HSA-8953854)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Mitotic g2-g2/m phases
(R-HSA-453274)
Mitotic metaphase and anaphase
(R-HSA-2555396)
M phase
(R-HSA-68886)
Neddylation
(R-HSA-8951664)
Nervous system development
(R-HSA-9675108)
Neutrophil degranulation
(R-HSA-6798695)
Nik-->noncanonical nf-kb signaling
(R-HSA-5676590)
Oxygen-dependent proline hydroxylation of hypoxia-inducible factor alpha
(R-HSA-1234176)
Pcp/ce pathway
(R-HSA-4086400)
Pip3 activates akt signaling
(R-HSA-1257604)
Post-translational protein modification
(R-HSA-597592)
Programmed cell death
(R-HSA-5357801)
Proteasome assembly
(R-HSA-9907900)
Raf/map kinase cascade
(R-HSA-5673001)
Regulation of activated pak-2p34 by proteasome mediated degradation
(R-HSA-211733)
Regulation of apoptosis
(R-HSA-169911)
Regulation of mitotic cell cycle
(R-HSA-453276)
Regulation of mrna stability by proteins that bind au-rich elements
(R-HSA-450531)
Regulation of ornithine decarboxylase (odc)
(R-HSA-350562)
Rna polymerase ii transcription
(R-HSA-73857)
Signaling by hedgehog
(R-HSA-5358351)
Signaling by interleukins
(R-HSA-449147)
Signaling by notch
(R-HSA-157118)
Signaling by notch4
(R-HSA-9013694)
Signaling by robo receptors
(R-HSA-376176)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Signaling by wnt
(R-HSA-195721)
Signal transduction
(R-HSA-162582)
S phase
(R-HSA-69242)
Tcf dependent signaling in response to wnt
(R-HSA-201681)
Tcr signaling
(R-HSA-202403)
Tnfr2 non-canonical nf-kb pathway
(R-HSA-5668541)
Transport of small molecules
(R-HSA-382551)
Uch proteinases
(R-HSA-5689603)
Viral infection pathways
(R-HSA-9824446)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 547.1720
Cell Significance Index: -85.1100
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 326.6200
Cell Significance Index: -82.8500
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 279.9992
Cell Significance Index: -115.3500
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 244.8203
Cell Significance Index: -99.4600
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 242.3629
Cell Significance Index: -114.4300
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 215.3639
Cell Significance Index: -110.7800
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 171.5517
Cell Significance Index: -115.1200
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 106.0076
Cell Significance Index: -101.2100
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 84.8773
Cell Significance Index: -104.6500
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 28.4741
Cell Significance Index: -112.3600
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 22.7550
Cell Significance Index: -60.9600
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 21.8887
Cell Significance Index: -67.2300
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 13.7463
Cell Significance Index: -30.0900
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 10.2200
Cell Significance Index: 1191.0300
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 3.4058
Cell Significance Index: 160.0700
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 3.1728
Cell Significance Index: 435.7100
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 3.1177
Cell Significance Index: 89.3700
Cell Name: granulosa cell (CL0000501)
Fold Change: 3.0907
Cell Significance Index: 81.2700
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 3.0395
Cell Significance Index: 105.6200
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 2.9405
Cell Significance Index: 61.5500
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 2.9201
Cell Significance Index: 136.1500
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 2.8580
Cell Significance Index: 31.0700
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 2.7699
Cell Significance Index: 81.3500
Cell Name: cell in vitro (CL0001034)
Fold Change: 2.7594
Cell Significance Index: 1506.9800
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 2.4644
Cell Significance Index: 67.0800
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 2.4032
Cell Significance Index: 283.4100
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 2.3899
Cell Significance Index: 27.1500
Cell Name: early pro-B cell (CL0002046)
Fold Change: 2.3650
Cell Significance Index: 152.5800
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 2.3608
Cell Significance Index: 1043.7800
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 2.3470
Cell Significance Index: 174.9200
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 2.3157
Cell Significance Index: 284.7400
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 2.2057
Cell Significance Index: 397.6300
Cell Name: kidney cell (CL1000497)
Fold Change: 2.1993
Cell Significance Index: 17.5600
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 2.1260
Cell Significance Index: 150.3600
Cell Name: lactocyte (CL0002325)
Fold Change: 2.0987
Cell Significance Index: 271.1400
Cell Name: peg cell (CL4033014)
Fold Change: 2.0036
Cell Significance Index: 46.2900
Cell Name: odontoblast (CL0000060)
Fold Change: 1.9943
Cell Significance Index: 255.6600
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.6171
Cell Significance Index: 43.1800
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 1.2882
Cell Significance Index: 67.1000
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.1141
Cell Significance Index: 57.8800
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 1.0708
Cell Significance Index: 56.2200
Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.0286
Cell Significance Index: 204.1300
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.9773
Cell Significance Index: 9.0000
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.7764
Cell Significance Index: 155.7500
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 0.7238
Cell Significance Index: 12.7900
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.6547
Cell Significance Index: 12.1000
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.6135
Cell Significance Index: 60.6900
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.5925
Cell Significance Index: 101.1700
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.2754
Cell Significance Index: 98.7800
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.2030
Cell Significance Index: 153.6400
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1226
Cell Significance Index: 23.3300
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0987
Cell Significance Index: 72.3400
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.0280
Cell Significance Index: 1.2700
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.0063
Cell Significance Index: 0.1100
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0023
Cell Significance Index: -4.3500
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: -0.0066
Cell Significance Index: -4.5400
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0175
Cell Significance Index: -0.4500
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0331
Cell Significance Index: -24.5300
Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.0383
Cell Significance Index: -2.3000
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0552
Cell Significance Index: -101.8500
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0572
Cell Significance Index: -35.7200
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0579
Cell Significance Index: -5.9200
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0670
Cell Significance Index: -103.1400
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0826
Cell Significance Index: -112.3600
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.1063
Cell Significance Index: -67.5100
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.1075
Cell Significance Index: -5.4400
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1274
Cell Significance Index: -71.8300
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.1735
Cell Significance Index: -78.7500
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1766
Cell Significance Index: -37.2000
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.1769
Cell Significance Index: -11.1500
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.3124
Cell Significance Index: -89.9000
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.4008
Cell Significance Index: -10.2400
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.4068
Cell Significance Index: -16.6700
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.4162
Cell Significance Index: -11.6300
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.4968
Cell Significance Index: -56.9200
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.5352
Cell Significance Index: -77.8000
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.5992
Cell Significance Index: -68.4000
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.6728
Cell Significance Index: -21.5500
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.6833
Cell Significance Index: -24.0100
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -0.7055
Cell Significance Index: -9.0400
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.7290
Cell Significance Index: -55.9500
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.7435
Cell Significance Index: -51.4200
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.7543
Cell Significance Index: -59.7400
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.8599
Cell Significance Index: -48.2600
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -1.0472
Cell Significance Index: -109.0400
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -1.0492
Cell Significance Index: -14.3200
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -1.1387
Cell Significance Index: -6.8800
Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: -1.1614
Cell Significance Index: -9.9800
Cell Name: helper T cell (CL0000912)
Fold Change: -1.4230
Cell Significance Index: -20.2200
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -1.5057
Cell Significance Index: -32.6200
Cell Name: type I muscle cell (CL0002211)
Fold Change: -1.6750
Cell Significance Index: -40.8700
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -1.6990
Cell Significance Index: -45.5300
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -1.7274
Cell Significance Index: -14.5100
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.8405
Cell Significance Index: -112.8400
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -1.9311
Cell Significance Index: -85.4200
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -1.9381
Cell Significance Index: -29.0400
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: -1.9514
Cell Significance Index: -12.1300
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -2.0036
Cell Significance Index: -59.0200
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -2.0453
Cell Significance Index: -35.0500
Cell Name: retinal rod cell (CL0000604)
Fold Change: -2.2478
Cell Significance Index: -26.8000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** 1. **Proteasome subunit beta 1**: PSMB1 is a beta subunit of the 20S proteasome, a large protein complex responsible for the degradation of proteins. 2. **Ubiquitin-proteasome pathway**: PSMB1 is involved in the ubiquitin-proteasome pathway, which degrades proteins tagged with ubiquitin, a small protein that marks proteins for degradation. 3. **Highly expressed in immune cells**: PSMB1 is highly expressed in immune cells, such as T cells, B cells, and macrophages, suggesting its importance in immune function. 4. **Regulation of cell cycle progression**: PSMB1 is involved in the regulation of cell cycle progression, particularly in the G2/M phase, where it regulates the degradation of proteins that control cell cycle checkpoint. **Pathways and Functions** 1. **Antigen processing and presentation**: PSMB1 is involved in the processing and presentation of antigens to T cells, which is crucial for the initiation of immune responses. 2. **Cell cycle regulation**: PSMB1 regulates the degradation of proteins that control cell cycle progression, ensuring proper cell division and preventing uncontrolled cell growth. 3. **Immune response regulation**: PSMB1 is involved in the regulation of immune responses, including the activation of T cells and the production of cytokines. 4. **Protein degradation**: PSMB1 is involved in the degradation of damaged or misfolded proteins, regulating protein quality control and maintaining cellular homeostasis. **Clinical Significance** 1. **Autoimmune diseases**: Dysfunction of PSMB1 has been implicated in autoimmune diseases, such as rheumatoid arthritis and lupus, where the immune system attacks healthy tissues. 2. **Cancer**: Alterations in PSMB1 expression have been observed in various types of cancer, including lymphoma and leukemia, where the proteasome plays a key role in cancer cell survival and proliferation. 3. **Neurodegenerative diseases**: PSMB1 has been implicated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, where protein misfolding and aggregation contribute to disease progression. 4. **Infectious diseases**: PSMB1 plays a crucial role in the regulation of immune responses to infections, such as HIV and tuberculosis, where the proteasome is involved in the degradation of pathogens and the activation of immune cells. In conclusion, PSMB1 is a critical gene involved in various cellular processes, including protein degradation, cell cycle progression, and immune response regulation. Its dysfunction has been implicated in various diseases, including autoimmune diseases, cancer, neurodegenerative diseases, and infectious diseases. Further research is needed to fully understand the role of PSMB1 in human health and disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Macropain subunit C5

Genular Protein ID: 405611575

Symbol: PSB1_HUMAN

Name: Macropain subunit C5

UniProtKB Accession Codes:

P20618 B5BU76 Q9BWA8

Database IDs:

Citations:

PubMed ID: 2025653

Title: Molecular cloning and sequence analysis of cDNAs for five major subunits of human proteasomes (multi-catalytic proteinase complexes).

PubMed ID: 2025653

DOI: 10.1016/0167-4781(91)90090-9

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2306472

Title: Relationships among the subunits of the high molecular weight proteinase, macropain (proteasome).

PubMed ID: 2306472

DOI: 10.1016/0167-4838(90)90165-c

PubMed ID: 8610016

Title: A role for the proteasome regulator PA28alpha in antigen presentation.

PubMed ID: 8610016

DOI: 10.1038/381166a0

PubMed ID: 12181345

Title: Clastosome: a subtype of nuclear body enriched in 19S and 20S proteasomes, ubiquitin, and protein substrates of proteasome.

PubMed ID: 12181345

DOI: 10.1091/mbc.e02-03-0122

PubMed ID: 14550573

Title: Human immunodeficiency virus-1 Tat protein interacts with distinct proteasomal alpha and beta subunits.

PubMed ID: 14550573

DOI: 10.1016/s0014-5793(03)01025-1

PubMed ID: 14732874

Title: Interaction of plasminogen activator inhibitor-2 and proteasome subunit, beta type 1.

PubMed ID: 14732874

DOI: 10.1093/abbs/36.1.42

PubMed ID: 15244466

Title: 20S proteasome prevents aggregation of heat-denatured proteins without PA700 regulatory subcomplex like a molecular chaperone.

PubMed ID: 15244466

DOI: 10.1021/bm049957a

PubMed ID: 17323924

Title: Mass spectrometric characterization of the affinity-purified human 26S proteasome complex.

PubMed ID: 17323924

DOI: 10.1021/bi061994u

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23495936

Title: Molecular architecture and assembly of the eukaryotic proteasome.

PubMed ID: 23495936

DOI: 10.1146/annurev-biochem-060410-150257

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27176742

Title: Human 20S proteasome activity towards fluorogenic peptides of various chain lengths.

PubMed ID: 27176742

DOI: 10.1515/hsz-2016-0176

PubMed ID: 26133119

Title: Cryo-EM reveals the conformation of a substrate analogue in the human 20S proteasome core.

PubMed ID: 26133119

DOI: 10.1038/ncomms8573

PubMed ID: 25599644

Title: Crystal structure of the human 20S proteasome in complex with carfilzomib.

PubMed ID: 25599644

DOI: 10.1016/j.str.2014.11.017

PubMed ID: 27428775

Title: An atomic structure of the human 26S proteasome.

PubMed ID: 27428775

DOI: 10.1038/nsmb.3273

PubMed ID: 27342858

Title: Structure of the human 26S proteasome at a resolution of 3.9 Aa.

PubMed ID: 27342858

DOI: 10.1073/pnas.1608050113

PubMed ID: 27493187

Title: The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design.

PubMed ID: 27493187

DOI: 10.1126/science.aaf8993

PubMed ID: 34711951

Title: AKIRIN2 controls the nuclear import of proteasomes in vertebrates.

PubMed ID: 34711951

DOI: 10.1038/s41586-021-04035-8

PubMed ID: 32129449

Title: Biallelic variants in PSMB1 encoding the proteasome subunit beta6 cause impairment of proteasome function, microcephaly, intellectual disability, developmental delay and short stature.

PubMed ID: 32129449

DOI: 10.1093/hmg/ddaa032

Sequence Information:

Length: 241
Mass: 26489
Checksum: AE8FC42799F39157
Sequence:

MLSSTAMYSA PGRDLGMEPH RAAGPLQLRF SPYVFNGGTI LAIAGEDFAI VASDTRLSEG 
FSIHTRDSPK CYKLTDKTVI GCSGFHGDCL TLTKIIEARL KMYKHSNNKA MTTGAIAAML 
STILYSRRFF PYYVYNIIGG LDEEGKGAVY SFDPVGSYQR DSFKAGGSAS AMLQPLLDNQ 
VGFKNMQNVE HVPLSLDRAM RLVKDVFISA AERDVYTGDA LRICIVTKEG IREETVSLRK 
D

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: PSMB1

Associated with

Cells (max top 100)

Other Information

Molecular cloning and sequence analysis of cDNAs for five major subunits of human proteasomes (multi-catalytic proteinase complexes). PubMed ID: 2025653

Human protein factory for converting the transcriptome into an in vitro-expressed proteome. PubMed ID: 19054851

The DNA sequence and analysis of human chromosome 6. PubMed ID: 14574404

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Relationships among the subunits of the high molecular weight proteinase, macropain (proteasome). PubMed ID: 2306472

A role for the proteasome regulator PA28alpha in antigen presentation. PubMed ID: 8610016

Clastosome: a subtype of nuclear body enriched in 19S and 20S proteasomes, ubiquitin, and protein substrates of proteasome. PubMed ID: 12181345

Human immunodeficiency virus-1 Tat protein interacts with distinct proteasomal alpha and beta subunits. PubMed ID: 14550573

Interaction of plasminogen activator inhibitor-2 and proteasome subunit, beta type 1. PubMed ID: 14732874

20S proteasome prevents aggregation of heat-denatured proteins without PA700 regulatory subcomplex like a molecular chaperone. PubMed ID: 15244466

Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. PubMed ID: 17323924

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Initial characterization of the human central proteome. PubMed ID: 21269460

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Molecular architecture and assembly of the eukaryotic proteasome. PubMed ID: 23495936

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Human 20S proteasome activity towards fluorogenic peptides of various chain lengths. PubMed ID: 27176742

Cryo-EM reveals the conformation of a substrate analogue in the human 20S proteasome core. PubMed ID: 26133119

Crystal structure of the human 20S proteasome in complex with carfilzomib. PubMed ID: 25599644

An atomic structure of the human 26S proteasome. PubMed ID: 27428775

Structure of the human 26S proteasome at a resolution of 3.9 Aa. PubMed ID: 27342858

The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design. PubMed ID: 27493187

AKIRIN2 controls the nuclear import of proteasomes in vertebrates. PubMed ID: 34711951

Biallelic variants in PSMB1 encoding the proteasome subunit beta6 cause impairment of proteasome function, microcephaly, intellectual disability, developmental delay and short stature. PubMed ID: 32129449