Details for: SAT1

Gene ID: 6303

Symbol: SAT1

Ensembl ID: ENSG00000130066

Description: spermidine/spermine N1-acetyltransferase 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: secretory cell (CL0000151)
    Fold Change: 5.45
    Marker Score: 9957
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 5.05
    Marker Score: 1823.5
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 4.64
    Marker Score: 157867
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 4.57
    Marker Score: 24015
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 4.46
    Marker Score: 249470
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 4.19
    Marker Score: 2853
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.19
    Marker Score: 10230
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 4.09
    Marker Score: 3488.5
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 4.06
    Marker Score: 3247
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 4.04
    Marker Score: 25769
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 3.97
    Marker Score: 2050
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 3.96
    Marker Score: 3097
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 3.95
    Marker Score: 25742
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 3.8
    Marker Score: 2538
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 3.78
    Marker Score: 4322
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.76
    Marker Score: 4019
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 3.74
    Marker Score: 13295
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 3.73
    Marker Score: 3961
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 3.68
    Marker Score: 8873
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 3.67
    Marker Score: 1780
  • Cell Name: club cell (CL0000158)
    Fold Change: 3.65
    Marker Score: 4264
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 3.64
    Marker Score: 9192
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 3.63
    Marker Score: 4725
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 3.62
    Marker Score: 4359
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 3.62
    Marker Score: 31405.5
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 3.61
    Marker Score: 26852.5
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 3.54
    Marker Score: 35091
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 3.54
    Marker Score: 2061
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 3.5
    Marker Score: 7932
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 3.47
    Marker Score: 55750
  • Cell Name: blood cell (CL0000081)
    Fold Change: 3.44
    Marker Score: 39949
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 3.44
    Marker Score: 12198
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 3.41
    Marker Score: 1094
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 3.4
    Marker Score: 11688
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 3.38
    Marker Score: 2562
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.38
    Marker Score: 117045
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 3.38
    Marker Score: 5373
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 3.38
    Marker Score: 5537.5
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 3.37
    Marker Score: 1405
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3.37
    Marker Score: 12980
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 3.35
    Marker Score: 6529.5
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 3.34
    Marker Score: 2037
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 3.33
    Marker Score: 8928.5
  • Cell Name: fat cell (CL0000136)
    Fold Change: 3.33
    Marker Score: 1860
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.31
    Marker Score: 791.5
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 3.29
    Marker Score: 3342
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.28
    Marker Score: 5972
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 3.25
    Marker Score: 2564.5
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 3.25
    Marker Score: 8515
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 3.25
    Marker Score: 10205
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 3.23
    Marker Score: 1450
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 3.23
    Marker Score: 72165.5
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 3.22
    Marker Score: 1390
  • Cell Name: basal cell (CL0000646)
    Fold Change: 3.21
    Marker Score: 4143
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 3.19
    Marker Score: 3979
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 3.18
    Marker Score: 2183
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 3.16
    Marker Score: 8857
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 3.15
    Marker Score: 8167
  • Cell Name: oocyte (CL0000023)
    Fold Change: 3.14
    Marker Score: 776.5
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 3.14
    Marker Score: 3303
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 3.13
    Marker Score: 1425
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 3.13
    Marker Score: 2669
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 3.12
    Marker Score: 1551
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 3.12
    Marker Score: 1056
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 3.1
    Marker Score: 14882
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 3.05
    Marker Score: 8428
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 3.05
    Marker Score: 1503
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 3.04
    Marker Score: 4890
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 3.04
    Marker Score: 1367.5
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 3.04
    Marker Score: 5032
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 3.03
    Marker Score: 2717
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 3.03
    Marker Score: 2550
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 3.02
    Marker Score: 3023.5
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 3.02
    Marker Score: 14846
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 3.02
    Marker Score: 2918
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 3.02
    Marker Score: 2007
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 3.02
    Marker Score: 1101
  • Cell Name: basophil (CL0000767)
    Fold Change: 2.99
    Marker Score: 1422
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.99
    Marker Score: 1705
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 2.99
    Marker Score: 7444
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 2.99
    Marker Score: 1092
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 2.98
    Marker Score: 1682
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 2.98
    Marker Score: 4222
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.98
    Marker Score: 76210.5
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.97
    Marker Score: 23228
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 2.96
    Marker Score: 1198
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 2.95
    Marker Score: 2910
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 2.95
    Marker Score: 849
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 2.94
    Marker Score: 2821
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 2.93
    Marker Score: 1195
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 2.93
    Marker Score: 927
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 2.92
    Marker Score: 1194
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 2.91
    Marker Score: 1213
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.91
    Marker Score: 4923
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 2.9
    Marker Score: 728
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 2.9
    Marker Score: 8453
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 2.89
    Marker Score: 1485
  • Cell Name: platelet (CL0000233)
    Fold Change: 2.88
    Marker Score: 1305
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 2.88
    Marker Score: 626.5
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.87
    Marker Score: 5730

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Other Information

**Key characteristics:** * SAT1 is a transmembrane protein with a molecular weight of approximately 120 kDa. * It is expressed in a variety of cell types, including secretory cell, mature microglial cell, fibroblast of mammary gland, epithelial cell of lung, CD14-positive, CD16-negative classical monocyte, squamous epithelial cell, basal cell of prostate epithelium, fibroblast of connective tissue of nonglandular part of prostate, early promyelocyte, foveolar cell of stomach. * SAT1 is a key enzyme in the metabolism of polyamines, and it plays a role in regulating cell growth, differentiation, and survival. **Pathways and functions:** * SAT1 is involved in the following pathways: * Angiogenesis * Cytosol * Diamine n-acetyltransferase activity * Identical protein binding * Interconversion of polyamines * Metabolism * Metabolism of amino acids and derivatives * Metabolism of polyamines * N-acetyltransferase activity * Polyamine biosynthetic process * Protein binding * Putrescine catabolic process * SAT1 catalyzes the acetylation of spermidine, a polyamine that is involved in various cellular processes, including cell signaling, differentiation, and proliferation. **Clinical significance:** * SAT1 mutations have been linked to several human diseases, including prostate cancer, breast cancer, and liver cancer. * Studies of SAT1 mutations have shown that they can lead to the activation of oncogenes and the development of cancer. * Therefore, SAT1 is a promising target for the development of novel cancer therapies.

Genular Protein ID: 3413918305

Symbol: SAT1_HUMAN

Name: N/A

UniProtKB Accession Codes:

P21673 Q6ICU9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 19 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 EC 3 EMBL 10 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 12 PDBsum 10 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 8 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1985966

Title: Isolation and characterization of a cDNA clone that codes for human spermidine/spermine N1-acetyltransferase.

PubMed ID: 1985966

DOI: 10.1016/s0021-9258(17)35245-6

PubMed ID: 1652956

Title: Characterization of a full-length cDNA which codes for the human spermidine/spermine N1-acetyltransferase.

PubMed ID: 1652956

DOI: 10.1016/0006-291x(91)91385-p

PubMed ID: 1417826

Title: Structure of the human spermidine/spermine N1-acetyltransferase gene (exon/intron gene organization and localization to Xp22.1).

PubMed ID: 1417826

DOI: 10.1016/0006-291x(92)90471-v

PubMed ID: 8573111

Title: Differential transcription of the human spermidine/spermine N1-acetyltransferase (SSAT) gene in human lung carcinoma cells.

PubMed ID: 8573111

DOI: 10.1042/bj3130691

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2241897

Title: High specific induction of spermidine/spermine N1-acetyltransferase in a human large cell lung carcinoma.

PubMed ID: 2241897

DOI: 10.1042/bj2700615

PubMed ID: 15283699

Title: Spermidine/spermine-N1-acetyltransferase-2 (SSAT2) acetylates thialysine and is not involved in polyamine metabolism.

PubMed ID: 15283699

DOI: 10.1042/bj20040790

PubMed ID: 16455797

Title: Structures of wild-type and mutant human spermidine/spermine N1-acetyltransferase, a potential therapeutic drug target.

PubMed ID: 16455797

DOI: 10.1073/pnas.0511008103

PubMed ID: 17516632

Title: Mechanistic and structural analysis of human spermidine/spermine N1-acetyltransferase.

PubMed ID: 17516632

DOI: 10.1021/bi700256z

PubMed ID: 16544326

Title: Crystal structure of human spermidine/spermine N1-acetyltransferase (hSSAT): the first structure of a new sequence family of transferase homologous superfamily.

PubMed ID: 16544326

DOI: 10.1002/prot.20965

PubMed ID: 12215835

Title: Gene dosage of the spermidine/spermine N(1)-acetyltransferase (SSAT) gene with putrescine accumulation in a patient with a Xp21.1p22.12 duplication and keratosis follicularis spinulosa decalvans (KFSD).

PubMed ID: 12215835

DOI: 10.1007/s00439-002-0791-6

Sequence Information:

  • Length: 171
  • Mass: 20024
  • Checksum: 6A0578B88CD72F09
  • Sequence:
    • MAKFVIRPAT AADCSDILRL IKELAKYEYM EEQVILTEKD LLEDGFGEHP FYHCLVAEVP 
KEHWTPEGHS IVGFAMYYFT YDPWIGKLLY LEDFFVMSDY RGFGIGSEIL KNLSQVAMRC 
RCSSMHFLVA EWNEPSINFY KRRGASDLSS EEGWRLFKID KEYLLKMATE E

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.