Details for: CL1001603

Cell ID: CL1001603

Cell Name: lung macrophage

Marker Score Threshold: 1144
(Derived using integrated single-cell and genomic data)

Description: Circulating macrophages and tissue macrophages (alveolar macrophages) of lung.

Synonyms: lung macrophages

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: AIF1 (ENSG00000204472)
    Fold Change: 3.93
    Ensembl ID: ENSG00000204472
  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 3.82
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.81
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 3.71
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 3.59
    Ensembl ID: ENSG00000184009
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 3.42
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 3.39
    Ensembl ID: ENSG00000135046
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 3.39
    Ensembl ID: ENSG00000182718
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 3.39
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 3.3
    Ensembl ID: ENSG00000135390
  • Gene Symbol: ARHGDIB (ENSG00000111348)
    Fold Change: 3.29
    Ensembl ID: ENSG00000111348
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 3.26
    Ensembl ID: ENSG00000145741
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 3.22
    Ensembl ID: ENSG00000117410
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 3.19
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 3.04
    Ensembl ID: ENSG00000185650
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 3.04
    Ensembl ID: ENSG00000169100
  • Gene Symbol: ALOX5AP (ENSG00000132965)
    Fold Change: 3.03
    Ensembl ID: ENSG00000132965
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 2.93
    Ensembl ID: ENSG00000084234
  • Gene Symbol: BLVRB (ENSG00000090013)
    Fold Change: 2.86
    Ensembl ID: ENSG00000090013
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 2.85
    Ensembl ID: ENSG00000005022
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 2.79
    Ensembl ID: ENSG00000154518
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 2.76
    Ensembl ID: ENSG00000069849
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 2.75
    Ensembl ID: ENSG00000152518
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2.68
    Ensembl ID: ENSG00000099624
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.67
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ALCAM (ENSG00000170017)
    Fold Change: 2.58
    Ensembl ID: ENSG00000170017
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 2.53
    Ensembl ID: ENSG00000104763
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 2.5
    Ensembl ID: ENSG00000143761
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.5
    Ensembl ID: ENSG00000154723
  • Gene Symbol: RHOG (ENSG00000177105)
    Fold Change: 2.48
    Ensembl ID: ENSG00000177105
  • Gene Symbol: AREG (ENSG00000109321)
    Fold Change: 2.45
    Ensembl ID: ENSG00000109321
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 2.43
    Ensembl ID: ENSG00000198931
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 2.42
    Ensembl ID: ENSG00000143878
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 2.4
    Ensembl ID: ENSG00000110955
  • Gene Symbol: ARRB2 (ENSG00000141480)
    Fold Change: 2.39
    Ensembl ID: ENSG00000141480
  • Gene Symbol: BST2 (ENSG00000130303)
    Fold Change: 2.36
    Ensembl ID: ENSG00000130303
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 2.22
    Ensembl ID: ENSG00000141522
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 2.2
    Ensembl ID: ENSG00000165629
  • Gene Symbol: ACP5 (ENSG00000102575)
    Fold Change: 2.2
    Ensembl ID: ENSG00000102575
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 2.15
    Ensembl ID: ENSG00000116459
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 2.08
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ATP6AP1 (ENSG00000071553)
    Fold Change: 2.03
    Ensembl ID: ENSG00000071553
  • Gene Symbol: ATP6V1B2 (ENSG00000147416)
    Fold Change: 2.03
    Ensembl ID: ENSG00000147416
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 2.02
    Ensembl ID: ENSG00000122359
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.98
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.95
    Ensembl ID: ENSG00000152234
  • Gene Symbol: BAX (ENSG00000087088)
    Fold Change: 1.94
    Ensembl ID: ENSG00000087088
  • Gene Symbol: ATF3 (ENSG00000162772)
    Fold Change: 1.93
    Ensembl ID: ENSG00000162772
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.93
    Ensembl ID: ENSG00000177556
  • Gene Symbol: PLIN2 (ENSG00000147872)
    Fold Change: 1.92
    Ensembl ID: ENSG00000147872
  • Gene Symbol: KLF9 (ENSG00000119138)
    Fold Change: 1.92
    Ensembl ID: ENSG00000119138
  • Gene Symbol: ALOX5 (ENSG00000012779)
    Fold Change: 1.89
    Ensembl ID: ENSG00000012779
  • Gene Symbol: AHR (ENSG00000106546)
    Fold Change: 1.87
    Ensembl ID: ENSG00000106546
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.84
    Ensembl ID: ENSG00000104765
  • Gene Symbol: ALDH2 (ENSG00000111275)
    Fold Change: 1.82
    Ensembl ID: ENSG00000111275
  • Gene Symbol: BCL2A1 (ENSG00000140379)
    Fold Change: 1.81
    Ensembl ID: ENSG00000140379
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 1.75
    Ensembl ID: ENSG00000172270
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.7
    Ensembl ID: ENSG00000128272
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.65
    Ensembl ID: ENSG00000104964
  • Gene Symbol: AUP1 (ENSG00000115307)
    Fold Change: 1.63
    Ensembl ID: ENSG00000115307
  • Gene Symbol: BNIP2 (ENSG00000140299)
    Fold Change: 1.6
    Ensembl ID: ENSG00000140299
  • Gene Symbol: APEX1 (ENSG00000100823)
    Fold Change: 1.57
    Ensembl ID: ENSG00000100823
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.56
    Ensembl ID: ENSG00000159199
  • Gene Symbol: ATP2B1 (ENSG00000070961)
    Fold Change: 1.55
    Ensembl ID: ENSG00000070961
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.52
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ANPEP (ENSG00000166825)
    Fold Change: 1.51
    Ensembl ID: ENSG00000166825
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.49
    Ensembl ID: ENSG00000163399
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.47
    Ensembl ID: ENSG00000004059
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 1.47
    Ensembl ID: ENSG00000168374
  • Gene Symbol: AKR1B1 (ENSG00000085662)
    Fold Change: 1.45
    Ensembl ID: ENSG00000085662
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 1.41
    Ensembl ID: ENSG00000196975
  • Gene Symbol: AP2A2 (ENSG00000183020)
    Fold Change: 1.39
    Ensembl ID: ENSG00000183020
  • Gene Symbol: APOC1 (ENSG00000130208)
    Fold Change: 1.37
    Ensembl ID: ENSG00000130208
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.34
    Ensembl ID: ENSG00000085224
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.34
    Ensembl ID: ENSG00000155366
  • Gene Symbol: BACH1 (ENSG00000156273)
    Fold Change: 1.34
    Ensembl ID: ENSG00000156273
  • Gene Symbol: ABL2 (ENSG00000143322)
    Fold Change: 1.33
    Ensembl ID: ENSG00000143322
  • Gene Symbol: ATP6V1E1 (ENSG00000131100)
    Fold Change: 1.33
    Ensembl ID: ENSG00000131100
  • Gene Symbol: BLVRA (ENSG00000106605)
    Fold Change: 1.31
    Ensembl ID: ENSG00000106605
  • Gene Symbol: AP1B1 (ENSG00000100280)
    Fold Change: 1.31
    Ensembl ID: ENSG00000100280
  • Gene Symbol: GRK2 (ENSG00000173020)
    Fold Change: 1.3
    Ensembl ID: ENSG00000173020
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.29
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.26
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ARHGAP4 (ENSG00000089820)
    Fold Change: 1.25
    Ensembl ID: ENSG00000089820
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.24
    Ensembl ID: ENSG00000107262
  • Gene Symbol: ARF3 (ENSG00000134287)
    Fold Change: 1.23
    Ensembl ID: ENSG00000134287
  • Gene Symbol: ACTN1 (ENSG00000072110)
    Fold Change: 1.19
    Ensembl ID: ENSG00000072110
  • Gene Symbol: A2M (ENSG00000175899)
    Fold Change: 1.15
    Ensembl ID: ENSG00000175899
  • Gene Symbol: ZFHX3 (ENSG00000140836)
    Fold Change: 1.14
    Ensembl ID: ENSG00000140836
  • Gene Symbol: ADAM10 (ENSG00000137845)
    Fold Change: 1.12
    Ensembl ID: ENSG00000137845
  • Gene Symbol: ATP6V1A (ENSG00000114573)
    Fold Change: 1.11
    Ensembl ID: ENSG00000114573
  • Gene Symbol: BCAT1 (ENSG00000060982)
    Fold Change: 1.1
    Ensembl ID: ENSG00000060982
  • Gene Symbol: BID (ENSG00000015475)
    Fold Change: 1.09
    Ensembl ID: ENSG00000015475
  • Gene Symbol: ACTN4 (ENSG00000130402)
    Fold Change: 1.07
    Ensembl ID: ENSG00000130402
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.06
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ATP2A2 (ENSG00000174437)
    Fold Change: 1.06
    Ensembl ID: ENSG00000174437
  • Gene Symbol: ADM (ENSG00000148926)
    Fold Change: 1.06
    Ensembl ID: ENSG00000148926
  • Gene Symbol: ATM (ENSG00000149311)
    Fold Change: 1.03
    Ensembl ID: ENSG00000149311
  • Gene Symbol: ACAA1 (ENSG00000060971)
    Fold Change: 1.02
    Ensembl ID: ENSG00000060971
  • Gene Symbol: ARL2 (ENSG00000213465)
    Fold Change: 1.01
    Ensembl ID: ENSG00000213465
Hovered Details

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Hovered Details

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**Key Characteristics** Lung macrophages are characterized by their ability to phagocytose foreign particles, bacteria, and dead cells. They are also involved in the presentation of antigens to T-cells, which is essential for the activation of immune responses. Lung macrophages are equipped with a range of surface receptors, including scavenger receptors, which allow them to recognize and bind to specific ligands. Lung macrophages are also involved in the regulation of immune responses, including the production of cytokines and chemokines that recruit other immune cells to the site of inflammation. They are also capable of producing reactive oxygen species (ROS) and nitric oxide (NO), which are involved in the killing of pathogens and the regulation of inflammatory responses. **Clinical Significance** Lung macrophages play a crucial role in the pathogenesis of various lung diseases, including COPD and asthma. In COPD, lung macrophages are involved in the accumulation of alveolar macrophages, which leads to chronic inflammation and tissue damage. In asthma, lung macrophages are involved in the regulation of airway inflammation and the production of cytokines and chemokines that recruit other immune cells to the site of inflammation. Lung macrophages are also involved in the pathogenesis of other lung diseases, including pneumonia, tuberculosis, and lung cancer. In pneumonia, lung macrophages are involved in the phagocytosis of bacteria and the production of cytokines and chemokines that recruit other immune cells to the site of inflammation. In tuberculosis, lung macrophages are involved in the presentation of antigens to T-cells and the production of cytokines and chemokines that recruit other immune cells to the site of inflammation. In lung cancer, lung macrophages are involved in the tumor microenvironment, where they regulate the growth and metastasis of cancer cells. Lung macrophages also play a role in the immunosurveillance of lung cancer, where they recognize and kill cancer cells. In summary, lung macrophages are a crucial component of the immune system in the lungs, and their dysregulation can lead to various lung diseases. Understanding the biology of lung macrophages is essential for the development of novel therapeutic strategies for the treatment of lung diseases.