Details for: ETV5

Gene ID: 2119

Symbol: ETV5

Ensembl ID: ENSG00000244405

Description: ETS variant transcription factor 5

Associated with

  • Cell differentiation
    (GO:0030154)
  • Cellular response to oxidative stress
    (GO:0034599)
  • Chromatin
    (GO:0000785)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna binding
    (GO:0003677)
  • Male germ-line stem cell asymmetric division
    (GO:0048133)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Positive regulation of glial cell proliferation
    (GO:0060252)
  • Positive regulation of neuron differentiation
    (GO:0045666)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Transcription cis-regulatory region binding
    (GO:0000976)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 171.3328
    Cell Significance Index: -26.6500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 102.5061
    Cell Significance Index: -26.0000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 68.0426
    Cell Significance Index: -28.0300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 54.7683
    Cell Significance Index: -22.2500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 23.3361
    Cell Significance Index: -22.2800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 21.6066
    Cell Significance Index: -26.6400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.7587
    Cell Significance Index: -26.6700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.6109
    Cell Significance Index: 90.4000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.4072
    Cell Significance Index: 37.5800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.0909
    Cell Significance Index: 107.9200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0137
    Cell Significance Index: 915.3300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.9765
    Cell Significance Index: 26.1700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.9700
    Cell Significance Index: 192.4900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8641
    Cell Significance Index: 173.3300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.7370
    Cell Significance Index: 25.6100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5529
    Cell Significance Index: 89.9300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.5125
    Cell Significance Index: 16.4200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4303
    Cell Significance Index: 46.8000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4000
    Cell Significance Index: 218.4500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3229
    Cell Significance Index: 223.3200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2675
    Cell Significance Index: 118.2900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2552
    Cell Significance Index: 11.2900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.1889
    Cell Significance Index: 5.3900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1614
    Cell Significance Index: 30.7100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1534
    Cell Significance Index: 10.8500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0726
    Cell Significance Index: 54.9800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0716
    Cell Significance Index: 4.3000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0379
    Cell Significance Index: 0.6500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0286
    Cell Significance Index: 43.9700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0204
    Cell Significance Index: 38.4400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0167
    Cell Significance Index: 0.4800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0145
    Cell Significance Index: 1.0100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0122
    Cell Significance Index: 22.4500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0082
    Cell Significance Index: 11.1900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0037
    Cell Significance Index: 1.3100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0037
    Cell Significance Index: 0.1400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0031
    Cell Significance Index: -0.0600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0049
    Cell Significance Index: -0.0400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0082
    Cell Significance Index: -5.1800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0122
    Cell Significance Index: -0.4300
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0194
    Cell Significance Index: -0.3000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0197
    Cell Significance Index: -2.3300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0287
    Cell Significance Index: -21.0500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0305
    Cell Significance Index: -5.2000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0327
    Cell Significance Index: -1.4800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0341
    Cell Significance Index: -3.4800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0352
    Cell Significance Index: -26.0900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0478
    Cell Significance Index: -29.8800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0481
    Cell Significance Index: -21.8500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0492
    Cell Significance Index: -27.7300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0620
    Cell Significance Index: -7.9500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0676
    Cell Significance Index: -9.8200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0718
    Cell Significance Index: -9.2700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0729
    Cell Significance Index: -20.9800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0731
    Cell Significance Index: -10.0400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0770
    Cell Significance Index: -13.8800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0830
    Cell Significance Index: -2.3200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0841
    Cell Significance Index: -9.8000
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0962
    Cell Significance Index: -1.1900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1126
    Cell Significance Index: -13.8500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1426
    Cell Significance Index: -6.7000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1459
    Cell Significance Index: -7.6600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1468
    Cell Significance Index: -30.9300
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.1583
    Cell Significance Index: -1.2000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1601
    Cell Significance Index: -4.0900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1605
    Cell Significance Index: -12.3200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1884
    Cell Significance Index: -11.5800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1895
    Cell Significance Index: -21.7100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2335
    Cell Significance Index: -14.7200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2338
    Cell Significance Index: -15.7200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2405
    Cell Significance Index: -25.0400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2456
    Cell Significance Index: -5.3200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2489
    Cell Significance Index: -5.3200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2948
    Cell Significance Index: -8.4500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2949
    Cell Significance Index: -13.7500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2968
    Cell Significance Index: -19.1500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3013
    Cell Significance Index: -23.8600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3079
    Cell Significance Index: -4.4100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3187
    Cell Significance Index: -23.7500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3189
    Cell Significance Index: -10.1600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3248
    Cell Significance Index: -16.9200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3248
    Cell Significance Index: -16.8700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3453
    Cell Significance Index: -21.1700
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.3696
    Cell Significance Index: -4.9300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.4298
    Cell Significance Index: -10.7200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4313
    Cell Significance Index: -11.3400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4349
    Cell Significance Index: -14.2400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4378
    Cell Significance Index: -11.7100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.4447
    Cell Significance Index: -22.4700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4556
    Cell Significance Index: -11.3900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4822
    Cell Significance Index: -8.0700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4858
    Cell Significance Index: -17.0200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.5037
    Cell Significance Index: -10.6900
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.5094
    Cell Significance Index: -5.6200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.5169
    Cell Significance Index: -10.8200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.6286
    Cell Significance Index: -12.4300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.6450
    Cell Significance Index: -12.9500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.6690
    Cell Significance Index: -18.2100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6730
    Cell Significance Index: -17.3000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6783
    Cell Significance Index: -19.9800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cell Type-Specific Expression:** ETV5 is expressed in a wide range of cell types, including epithelial cells, immune cells, neural cells, and stem cells. 2. **Transcriptional Regulation:** ETV5 acts as a transcriptional activator or repressor, depending on the context, and is involved in regulating the expression of various genes. 3. **Chromatin Remodeling:** ETV5 interacts with chromatin-modifying enzymes, such as histone acetyltransferases and histone deacetylases, to regulate chromatin structure and gene expression. 4. **Oxidative Stress Response:** ETV5 is involved in regulating the cellular response to oxidative stress, which is a critical process for maintaining cellular homeostasis. 5. **Immune Function:** ETV5 plays a role in regulating immune cell function, including the proliferation and differentiation of immune cells. **Pathways and Functions:** 1. **Cell Differentiation:** ETV5 regulates the differentiation of various cell types, including immune cells, neural cells, and stem cells. 2. **Oxidative Stress Response:** ETV5 is involved in regulating the cellular response to oxidative stress, which is a critical process for maintaining cellular homeostasis. 3. **Chromatin Remodeling:** ETV5 interacts with chromatin-modifying enzymes to regulate chromatin structure and gene expression. 4. **Transcriptional Regulation:** ETV5 acts as a transcriptional activator or repressor, depending on the context, and is involved in regulating the expression of various genes. 5. **Immune Function:** ETV5 plays a role in regulating immune cell function, including the proliferation and differentiation of immune cells. **Clinical Significance:** 1. **Cancer:** ETV5 has been implicated in the development and progression of various cancers, including lung, breast, and colon cancer. 2. **Autoimmune Disorders:** ETV5 has been implicated in the pathogenesis of autoimmune disorders, including rheumatoid arthritis and lupus. 3. **Neurodegenerative Diseases:** ETV5 has been implicated in the development and progression of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. 4. **Infectious Diseases:** ETV5 has been implicated in the regulation of the immune response to infectious diseases, including tuberculosis and HIV. 5. **Regenerative Medicine:** ETV5 has been implicated in the regulation of stem cell differentiation and proliferation, which has implications for regenerative medicine. In conclusion, ETV5 is a multifaceted gene that plays critical roles in regulating cell differentiation, response to oxidative stress, and immune function. Its dysregulation has been implicated in various diseases, including cancer, autoimmune disorders, and neurodegenerative diseases. Further research is needed to fully understand the functions of ETV5 and its role in human disease.

Genular Protein ID: 2323630501

Symbol: ETV5_HUMAN

Name: ETS translocation variant 5

UniProtKB Accession Codes:

P41161 A6NH46 B7Z7D7 Q6IBN5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 17 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8152800

Title: Molecular cloning and characterization of human ERM, a new member of the Ets family closely related to mouse PEA3 and ER81 transcription factors.

PubMed ID: 8152800

PubMed ID: 8661127

Title: Genomic organization of the human ERM (ETV5) gene, a PEA3 group member of ETS transcription factors.

PubMed ID: 8661127

DOI: 10.1006/geno.1996.0345

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11840567

Title: Cluster analysis of an extensive human breast cancer cell line protein expression map database.

PubMed ID: 11840567

DOI: 10.1002/1615-9861(200202)2:2<212::aid-prot212>3.0.co;2-h

PubMed ID: 17126306

Title: Analysis of transcriptional modulation of the presenilin 1 gene promoter by ZNF237, a candidate binding partner of the Ets transcription factor ERM.

PubMed ID: 17126306

DOI: 10.1016/j.brainres.2006.10.056

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 510
  • Mass: 57838
  • Checksum: B7CE40A33927F46E
  • Sequence:
    • MDGFYDQQVP FMVPGKSRSE ECRGRPVIDR KRKFLDTDLA HDSEELFQDL SQLQEAWLAE 
AQVPDDEQFV PDFQSDNLVL HAPPPTKIKR ELHSPSSELS SCSHEQALGA NYGEKCLYNY 
CAYDRKPPSG FKPLTPPTTP LSPTHQNPLF PPPQATLPTS GHAPAAGPVQ GVGPAPAPHS 
LPEPGPQQQT FAVPRPPHQP LQMPKMMPEN QYPSEQRFQR QLSEPCHPFP PQPGVPGDNR 
PSYHRQMSEP IVPAAPPPPQ GFKQEYHDPL YEHGVPGMPG PPAHGFQSPM GIKQEPRDYC 
VDSEVPNCQS SYMRGGYFSS SHEGFSYEKD PRLYFDDTCV VPERLEGKVK QEPTMYREGP 
PYQRRGSLQL WQFLVTLLDD PANAHFIAWT GRGMEFKLIE PEEVARRWGI QKNRPAMNYD 
KLSRSLRYYY EKGIMQKVAG ERYVYKFVCD PDALFSMAFP DNQRPFLKAE SECHLSEEDT 
LPLTHFEDSP AYLLDMDRCS SLPYAEGFAY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.