Details for: ETV5

Gene ID: 2119

Symbol: ETV5

Ensembl ID: ENSG00000244405

Description: ETS variant transcription factor 5

Associated with

  • Cell differentiation
    (GO:0030154)
  • Cellular response to oxidative stress
    (GO:0034599)
  • Chromatin
    (GO:0000785)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna binding
    (GO:0003677)
  • Male germ-line stem cell asymmetric division
    (GO:0048133)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Positive regulation of glial cell proliferation
    (GO:0060252)
  • Positive regulation of neuron differentiation
    (GO:0045666)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Transcription cis-regulatory region binding
    (GO:0000976)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 4.06
    Marker Score: 16912
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 2.25
    Marker Score: 1797
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.69
    Marker Score: 840
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.65
    Marker Score: 3360
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.63
    Marker Score: 2626
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.58
    Marker Score: 1983.5
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.56
    Marker Score: 10174
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168836
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.37
    Marker Score: 2108
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.31
    Marker Score: 3390
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.29
    Marker Score: 1592
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.25
    Marker Score: 688
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.24
    Marker Score: 2804.5
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.23
    Marker Score: 11666
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.17
    Marker Score: 11034
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.15
    Marker Score: 18016.5
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.15
    Marker Score: 1149
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.14
    Marker Score: 2674
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.11
    Marker Score: 11494
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.11
    Marker Score: 4369
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.09
    Marker Score: 313
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.06
    Marker Score: 433
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251767
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.03
    Marker Score: 373
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.03
    Marker Score: 18283
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71787
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48011
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.99
    Marker Score: 15915
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30404
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.97
    Marker Score: 313
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 496
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.95
    Marker Score: 299
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 450
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2409
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.95
    Marker Score: 5091
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.93
    Marker Score: 2224
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.92
    Marker Score: 752
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2731
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5114
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 318
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5296
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.86
    Marker Score: 5138
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.85
    Marker Score: 7339
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.84
    Marker Score: 726
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.84
    Marker Score: 51676
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.83
    Marker Score: 1738
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.82
    Marker Score: 494
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.79
    Marker Score: 379
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 597
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.78
    Marker Score: 1082
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.78
    Marker Score: 312
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.77
    Marker Score: 3211
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1243
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.76
    Marker Score: 806
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.75
    Marker Score: 1256
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 386
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.74
    Marker Score: 265
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.73
    Marker Score: 666
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.72
    Marker Score: 1314
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.71
    Marker Score: 24664
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 0.71
    Marker Score: 235
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.67
    Marker Score: 1077
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.67
    Marker Score: 6739.5
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.67
    Marker Score: 761
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.66
    Marker Score: 760
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.66
    Marker Score: 384
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.64
    Marker Score: 600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.64
    Marker Score: 1081
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.63
    Marker Score: 766
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.63
    Marker Score: 13427
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.62
    Marker Score: 619
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.62
    Marker Score: 2029
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.59
    Marker Score: 3099
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.58
    Marker Score: 11530
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.58
    Marker Score: 698
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.58
    Marker Score: 370
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.57
    Marker Score: 595
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.57
    Marker Score: 610
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.55
    Marker Score: 610
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 439
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.54
    Marker Score: 579
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.54
    Marker Score: 242
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.54
    Marker Score: 238
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.54
    Marker Score: 338
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.53
    Marker Score: 2602
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.52
    Marker Score: 343
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.52
    Marker Score: 579
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.51
    Marker Score: 720
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.51
    Marker Score: 780
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.51
    Marker Score: 2062
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.5
    Marker Score: 527
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.5
    Marker Score: 278
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.49
    Marker Score: 116
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.49
    Marker Score: 359
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.49
    Marker Score: 322
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.48
    Marker Score: 307
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.48
    Marker Score: 233
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.48
    Marker Score: 125
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.48
    Marker Score: 16254

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Other Information

**Key characteristics:** - ETV5 is a protein with a predicted molecular weight of approximately 300 kDa. - It is a member of the ETS family of transcription factors, which are known for their ability to regulate gene expression by binding to specific DNA sequences. - ETV5 is a key regulator of epithelial cell proliferation in the developing and adult respiratory tract. - It is also involved in the regulation of neuronal differentiation, glial cell proliferation, and immune cell function. **Pathways and functions:** - ETV5 is involved in cell differentiation by promoting the expression of genes involved in epithelial cell fate and suppressing the expression of genes associated with neural differentiation. - It also plays a role in maintaining genomic integrity by regulating the expression of genes involved in DNA repair and repair mechanisms. - In the context of cancer, ETV5 is often overexpressed in cancer cells, where it promotes tumor growth and metastasis. - It is also involved in the regulation of immune responses by promoting the differentiation of naive T cells into regulatory T cells. **Clinical significance:** - Mutations in ETV5 have been linked to several human cancers, including lung cancer, breast cancer, and colon cancer. - Targeting ETV5 has emerged as a promising therapeutic strategy for cancer treatment. - Clinical trials are currently evaluating the use of ETV5 inhibitors as a means of inhibiting cancer growth and metastasis.

Genular Protein ID: 2323630501

Symbol: ETV5_HUMAN

Name: ETS translocation variant 5

UniProtKB Accession Codes:

P41161 A6NH46 B7Z7D7 Q6IBN5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 17 Ensembl 2 ExpressionAtlas 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 2 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8152800

Title: Molecular cloning and characterization of human ERM, a new member of the Ets family closely related to mouse PEA3 and ER81 transcription factors.

PubMed ID: 8152800

PubMed ID: 8661127

Title: Genomic organization of the human ERM (ETV5) gene, a PEA3 group member of ETS transcription factors.

PubMed ID: 8661127

DOI: 10.1006/geno.1996.0345

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11840567

Title: Cluster analysis of an extensive human breast cancer cell line protein expression map database.

PubMed ID: 11840567

DOI: 10.1002/1615-9861(200202)2:2<212::aid-prot212>3.0.co;2-h

PubMed ID: 17126306

Title: Analysis of transcriptional modulation of the presenilin 1 gene promoter by ZNF237, a candidate binding partner of the Ets transcription factor ERM.

PubMed ID: 17126306

DOI: 10.1016/j.brainres.2006.10.056

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 510
  • Mass: 57838
  • Checksum: B7CE40A33927F46E
  • Sequence:
    • MDGFYDQQVP FMVPGKSRSE ECRGRPVIDR KRKFLDTDLA HDSEELFQDL SQLQEAWLAE 
AQVPDDEQFV PDFQSDNLVL HAPPPTKIKR ELHSPSSELS SCSHEQALGA NYGEKCLYNY 
CAYDRKPPSG FKPLTPPTTP LSPTHQNPLF PPPQATLPTS GHAPAAGPVQ GVGPAPAPHS 
LPEPGPQQQT FAVPRPPHQP LQMPKMMPEN QYPSEQRFQR QLSEPCHPFP PQPGVPGDNR 
PSYHRQMSEP IVPAAPPPPQ GFKQEYHDPL YEHGVPGMPG PPAHGFQSPM GIKQEPRDYC 
VDSEVPNCQS SYMRGGYFSS SHEGFSYEKD PRLYFDDTCV VPERLEGKVK QEPTMYREGP 
PYQRRGSLQL WQFLVTLLDD PANAHFIAWT GRGMEFKLIE PEEVARRWGI QKNRPAMNYD 
KLSRSLRYYY EKGIMQKVAG ERYVYKFVCD PDALFSMAFP DNQRPFLKAE SECHLSEEDT 
LPLTHFEDSP AYLLDMDRCS SLPYAEGFAY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.