Details for: SERPINB2

Gene ID: 5055

Symbol: SERPINB2

Ensembl ID: ENSG00000197632

Description: serpin family B member 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 53.7624
    Cell Significance Index: 159.8900
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 47.2531
    Cell Significance Index: -7.3500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 29.5691
    Cell Significance Index: -7.5000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 14.6459
    Cell Significance Index: -5.9500
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: 11.4303
    Cell Significance Index: 82.3500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 6.2320
    Cell Significance Index: -5.9500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 5.9532
    Cell Significance Index: -7.3400
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 3.9653
    Cell Significance Index: 57.5700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.8804
    Cell Significance Index: -7.4200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.0070
    Cell Significance Index: 15.5800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5971
    Cell Significance Index: 31.0200
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.5243
    Cell Significance Index: 3.3400
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.3453
    Cell Significance Index: 1.9800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.3071
    Cell Significance Index: 4.1900
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.2863
    Cell Significance Index: 2.4600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.2311
    Cell Significance Index: 3.2900
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.2201
    Cell Significance Index: 2.2700
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.1355
    Cell Significance Index: 1.5600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1040
    Cell Significance Index: 45.9700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.0898
    Cell Significance Index: 1.6600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0780
    Cell Significance Index: 9.0900
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.0561
    Cell Significance Index: 0.9000
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0534
    Cell Significance Index: 0.7500
  • Cell Name: CD14-positive, CD16-low monocyte (CL0001055)
    Fold Change: 0.0499
    Cell Significance Index: 0.4800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.0196
    Cell Significance Index: 0.4900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0170
    Cell Significance Index: 1.9500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0022
    Cell Significance Index: -1.3700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0028
    Cell Significance Index: -5.2700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0032
    Cell Significance Index: -2.3500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0040
    Cell Significance Index: -7.4400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0041
    Cell Significance Index: -0.1100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0049
    Cell Significance Index: -2.7600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0049
    Cell Significance Index: -7.5800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0065
    Cell Significance Index: -8.8000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0073
    Cell Significance Index: -5.5600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0101
    Cell Significance Index: -6.4300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0130
    Cell Significance Index: -2.7300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0140
    Cell Significance Index: -1.7300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0147
    Cell Significance Index: -8.0400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0167
    Cell Significance Index: -2.8500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0168
    Cell Significance Index: -7.6100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0191
    Cell Significance Index: -3.4500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0194
    Cell Significance Index: -0.5000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0208
    Cell Significance Index: -7.4700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0273
    Cell Significance Index: -7.8500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0291
    Cell Significance Index: -3.7300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0329
    Cell Significance Index: -3.7500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0334
    Cell Significance Index: -6.6400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0342
    Cell Significance Index: -6.8700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0378
    Cell Significance Index: -5.4900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0468
    Cell Significance Index: -6.0500
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0474
    Cell Significance Index: -0.4500
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: -0.0593
    Cell Significance Index: -0.4900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0615
    Cell Significance Index: -8.4400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0701
    Cell Significance Index: -7.3000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0720
    Cell Significance Index: -7.3500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0866
    Cell Significance Index: -1.2400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1069
    Cell Significance Index: -5.5700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1077
    Cell Significance Index: -8.0300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1099
    Cell Significance Index: -7.3900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1163
    Cell Significance Index: -7.5000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1181
    Cell Significance Index: -7.2600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1204
    Cell Significance Index: -9.2400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1305
    Cell Significance Index: -4.7900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1331
    Cell Significance Index: -3.7200
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1372
    Cell Significance Index: -2.0000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1378
    Cell Significance Index: -6.9700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1405
    Cell Significance Index: -6.6100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1545
    Cell Significance Index: -7.2100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1648
    Cell Significance Index: -4.8600
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.1657
    Cell Significance Index: -1.1000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1697
    Cell Significance Index: -9.5200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1709
    Cell Significance Index: -4.9000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1722
    Cell Significance Index: -4.1700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1803
    Cell Significance Index: -7.3900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1809
    Cell Significance Index: -8.2000
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.1809
    Cell Significance Index: -1.2000
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.1948
    Cell Significance Index: -2.3700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2043
    Cell Significance Index: -7.1000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2078
    Cell Significance Index: -7.2800
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.2086
    Cell Significance Index: -2.4700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2123
    Cell Significance Index: -4.1500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2127
    Cell Significance Index: -9.4100
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2245
    Cell Significance Index: -9.7600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2386
    Cell Significance Index: -5.9500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2407
    Cell Significance Index: -7.8800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2411
    Cell Significance Index: -7.6800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2437
    Cell Significance Index: -6.5200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2482
    Cell Significance Index: -9.4000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2609
    Cell Significance Index: -6.9900
  • Cell Name: peridermal cell (CL0000078)
    Fold Change: -0.2630
    Cell Significance Index: -1.6400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2647
    Cell Significance Index: -5.5400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2685
    Cell Significance Index: -7.0600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2712
    Cell Significance Index: -7.7400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2857
    Cell Significance Index: -7.2800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2873
    Cell Significance Index: -7.3400
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.2948
    Cell Significance Index: -4.4100
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.3032
    Cell Significance Index: -9.5900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3059
    Cell Significance Index: -5.1200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3069
    Cell Significance Index: -7.6600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Serine-type endopeptidase inhibitor activity:** SERPINB2 possesses the ability to inhibit the activity of serine proteases, which are involved in various cellular processes, including proteolysis, apoptosis, and cell signaling. 2. **Widespread expression:** SERPINB2 is expressed in multiple cell types, including glial cells, epithelial cells, immune cells, and stem cells, indicating its involvement in various physiological and pathological processes. 3. **Involvement in immune responses:** SERPINB2 has been implicated in the regulation of immune responses, including cytokine signaling, apoptosis, and endopeptidase activity. 4. **Hemostasis:** SERPINB2 plays a crucial role in hemostasis by inhibiting the activity of plasminogen activators, which are involved in fibrinolysis and clot dissolution. **Pathways and Functions:** 1. **Cytokine signaling in immune system:** SERPINB2 has been shown to regulate cytokine signaling pathways, including the interleukin-12 (IL-12) signaling pathway, which is critical for the regulation of immune responses. 2. **Negative regulation of apoptotic process:** SERPINB2 inhibits the activity of caspases, which are key regulators of apoptosis, thereby exerting a negative regulatory effect on programmed cell death. 3. **Negative regulation of endopeptidase activity:** SERPINB2 inhibits the activity of endopeptidases, which are involved in the processing and degradation of various proteins. 4. **Fibrinolysis:** SERPINB2 inhibits the activity of plasminogen activators, which are involved in fibrinolysis and clot dissolution, thereby regulating hemostasis. **Clinical Significance:** 1. **Inflammatory diseases:** Alterations in SERPINB2 expression have been implicated in various inflammatory diseases, including rheumatoid arthritis, multiple sclerosis, and atherosclerosis. 2. **Cancer:** SERPINB2 has been shown to regulate cancer cell growth, invasion, and metastasis, highlighting its potential as a therapeutic target in cancer treatment. 3. **Neurological disorders:** SERPINB2 has been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis, highlighting its potential as a therapeutic target in these diseases. 4. **Hemostatic disorders:** SERPINB2 plays a critical role in hemostasis, and alterations in its expression have been implicated in various hemostatic disorders, including thrombotic disorders and bleeding disorders. In conclusion, SERPINB2 is a critical regulator of immune responses and hemostasis, and its dysregulation has been implicated in various physiological and pathological processes. Further research is needed to fully understand the role of SERPINB2 in these processes and to explore its potential as a therapeutic target in various diseases.

Genular Protein ID: 427403369

Symbol: PAI2_HUMAN

Name: Plasminogen activator inhibitor 2

UniProtKB Accession Codes:

P05120 Q96E96

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EMBL 17 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 8 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3029122

Title: cDNA cloning and expression in Escherichia coli of a plasminogen activator inhibitor from human placenta.

PubMed ID: 3029122

DOI: 10.1016/s0021-9258(18)61414-0

PubMed ID: 3325828

Title: Plasminogen activator inhibitor 2: regulation of gene transcription during phorbol ester-mediated differentiation of U-937 human histiocytic lymphoma cells.

PubMed ID: 3325828

DOI: 10.1128/mcb.7.12.4564-4567.1987

PubMed ID: 3496414

Title: Human monocyte Arg-Serpin cDNA. Sequence, chromosomal assignment, and homology to plasminogen activator-inhibitor.

PubMed ID: 3496414

DOI: 10.1084/jem.166.1.77

PubMed ID: 3257578

Title: Cloning and expression of a cDNA coding for a human monocyte-derived plasminogen activator inhibitor.

PubMed ID: 3257578

DOI: 10.1073/pnas.85.4.985

PubMed ID: 2494165

Title: Structure of the gene for human plasminogen activator inhibitor-2. The nearest mammalian homologue of chicken ovalbumin.

PubMed ID: 2494165

DOI: 10.1016/s0021-9258(18)83572-4

PubMed ID: 2303256

Title: Chromosomal organization and localization of the human urokinase inhibitor gene: perfect structural conservation with ovalbumin.

PubMed ID: 2303256

DOI: 10.1016/0888-7543(90)90461-3

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1286667

Title: Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.

PubMed ID: 1286667

DOI: 10.1002/elps.11501301199

PubMed ID: 14732874

Title: Interaction of plasminogen activator inhibitor-2 and proteasome subunit, beta type 1.

PubMed ID: 14732874

DOI: 10.1093/abbs/36.1.42

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 10368272

Title: The crystal structure of plasminogen activator inhibitor 2 at 2.0-A resolution: implications for serpin function.

PubMed ID: 10368272

DOI: 10.1016/s0969-2126(99)80008-2

PubMed ID: 10391209

Title: Characterization of single-nucleotide polymorphisms in coding regions of human genes.

PubMed ID: 10391209

DOI: 10.1038/10290

Sequence Information:

  • Length: 415
  • Mass: 46596
  • Checksum: 10DFAB5A4B1246FF
  • Sequence:
    • MEDLCVANTL FALNLFKHLA KASPTQNLFL SPWSISSTMA MVYMGSRGST EDQMAKVLQF 
NEVGANAVTP MTPENFTSCG FMQQIQKGSY PDAILQAQAA DKIHSSFRSL SSAINASTGN 
YLLESVNKLF GEKSASFREE YIRLCQKYYS SEPQAVDFLE CAEEARKKIN SWVKTQTKGK 
IPNLLPEGSV DGDTRMVLVN AVYFKGKWKT PFEKKLNGLY PFRVNSAQRT PVQMMYLREK 
LNIGYIEDLK AQILELPYAG DVSMFLLLPD EIADVSTGLE LLESEITYDK LNKWTSKDKM 
AEDEVEVYIP QFKLEEHYEL RSILRSMGME DAFNKGRANF SGMSERNDLF LSEVFHQAMV 
DVNEEGTEAA AGTGGVMTGR TGHGGPQFVA DHPFLFLIMH KITNCILFFG RFSSP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.