Details for: CL0000432

Cell ID: CL0000432

Cell Name: reticular cell

Marker Score Threshold: 365
(Derived using integrated single-cell and genomic data)

Description: A fibroblast that synthesizes collagen and uses it to produce reticular fibers, thus providing structural support. Reticular cells are found in many organs, including the spleen, lymph nodes and kidneys. Subtypes of reticular cells include epithelial, mesenchymal, and fibroblastic reticular cells. Fibroblastic reticular cells are involved in directing B cells and T cells to specific regions within a tissue, whereas epithelial and mesenchymal reticular cells are associated with certain areas of the brain.

Synonyms: reticulum cell

Genes (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Gene Symbol: ACTB (ENSG00000075624)
    Fold Change: 4.01
    Ensembl ID: ENSG00000075624
  • Gene Symbol: B2M (ENSG00000166710)
    Fold Change: 3.82
    Ensembl ID: ENSG00000166710
  • Gene Symbol: ACTG1 (ENSG00000184009)
    Fold Change: 3.44
    Ensembl ID: ENSG00000184009
  • Gene Symbol: CALM2 (ENSG00000143933)
    Fold Change: 3.24
    Ensembl ID: ENSG00000143933
  • Gene Symbol: SLC25A6 (ENSG00000169100)
    Fold Change: 3.17
    Ensembl ID: ENSG00000169100
  • Gene Symbol: CD63 (ENSG00000135404)
    Fold Change: 3.13
    Ensembl ID: ENSG00000135404
  • Gene Symbol: CFL1 (ENSG00000172757)
    Fold Change: 3.08
    Ensembl ID: ENSG00000172757
  • Gene Symbol: BTF3 (ENSG00000145741)
    Fold Change: 3.06
    Ensembl ID: ENSG00000145741
  • Gene Symbol: BTG1 (ENSG00000133639)
    Fold Change: 2.97
    Ensembl ID: ENSG00000133639
  • Gene Symbol: ANXA2 (ENSG00000182718)
    Fold Change: 2.96
    Ensembl ID: ENSG00000182718
  • Gene Symbol: ATP5F1E (ENSG00000124172)
    Fold Change: 2.93
    Ensembl ID: ENSG00000124172
  • Gene Symbol: ZFP36L1 (ENSG00000185650)
    Fold Change: 2.92
    Ensembl ID: ENSG00000185650
  • Gene Symbol: RHOA (ENSG00000067560)
    Fold Change: 2.83
    Ensembl ID: ENSG00000067560
  • Gene Symbol: ZFP36L2 (ENSG00000152518)
    Fold Change: 2.8
    Ensembl ID: ENSG00000152518
  • Gene Symbol: CALM1 (ENSG00000198668)
    Fold Change: 2.79
    Ensembl ID: ENSG00000198668
  • Gene Symbol: TMEM258 (ENSG00000134825)
    Fold Change: 2.63
    Ensembl ID: ENSG00000134825
  • Gene Symbol: CD81 (ENSG00000110651)
    Fold Change: 2.56
    Ensembl ID: ENSG00000110651
  • Gene Symbol: ANXA1 (ENSG00000135046)
    Fold Change: 2.52
    Ensembl ID: ENSG00000135046
  • Gene Symbol: CDC42 (ENSG00000070831)
    Fold Change: 2.5
    Ensembl ID: ENSG00000070831
  • Gene Symbol: CD44 (ENSG00000026508)
    Fold Change: 2.49
    Ensembl ID: ENSG00000026508
  • Gene Symbol: ANXA5 (ENSG00000164111)
    Fold Change: 2.38
    Ensembl ID: ENSG00000164111
  • Gene Symbol: ALDOA (ENSG00000149925)
    Fold Change: 2.36
    Ensembl ID: ENSG00000149925
  • Gene Symbol: ATP5MC2 (ENSG00000135390)
    Fold Change: 2.3
    Ensembl ID: ENSG00000135390
  • Gene Symbol: BSG (ENSG00000172270)
    Fold Change: 2.28
    Ensembl ID: ENSG00000172270
  • Gene Symbol: CEBPB (ENSG00000172216)
    Fold Change: 2.26
    Ensembl ID: ENSG00000172216
  • Gene Symbol: TSPO (ENSG00000100300)
    Fold Change: 2.25
    Ensembl ID: ENSG00000100300
  • Gene Symbol: ARF4 (ENSG00000168374)
    Fold Change: 2.23
    Ensembl ID: ENSG00000168374
  • Gene Symbol: CD9 (ENSG00000010278)
    Fold Change: 2.22
    Ensembl ID: ENSG00000010278
  • Gene Symbol: CD59 (ENSG00000085063)
    Fold Change: 2.14
    Ensembl ID: ENSG00000085063
  • Gene Symbol: CEBPD (ENSG00000221869)
    Fold Change: 2.11
    Ensembl ID: ENSG00000221869
  • Gene Symbol: ATP5ME (ENSG00000169020)
    Fold Change: 2.1
    Ensembl ID: ENSG00000169020
  • Gene Symbol: ATP5PF (ENSG00000154723)
    Fold Change: 2.07
    Ensembl ID: ENSG00000154723
  • Gene Symbol: ATP5F1D (ENSG00000099624)
    Fold Change: 2
    Ensembl ID: ENSG00000099624
  • Gene Symbol: APP (ENSG00000142192)
    Fold Change: 1.99
    Ensembl ID: ENSG00000142192
  • Gene Symbol: ATF4 (ENSG00000128272)
    Fold Change: 1.95
    Ensembl ID: ENSG00000128272
  • Gene Symbol: CAPZB (ENSG00000077549)
    Fold Change: 1.93
    Ensembl ID: ENSG00000077549
  • Gene Symbol: CAST (ENSG00000153113)
    Fold Change: 1.93
    Ensembl ID: ENSG00000153113
  • Gene Symbol: CALR (ENSG00000179218)
    Fold Change: 1.89
    Ensembl ID: ENSG00000179218
  • Gene Symbol: SLC25A5 (ENSG00000005022)
    Fold Change: 1.88
    Ensembl ID: ENSG00000005022
  • Gene Symbol: CD47 (ENSG00000196776)
    Fold Change: 1.87
    Ensembl ID: ENSG00000196776
  • Gene Symbol: APRT (ENSG00000198931)
    Fold Change: 1.85
    Ensembl ID: ENSG00000198931
  • Gene Symbol: ARF6 (ENSG00000165527)
    Fold Change: 1.83
    Ensembl ID: ENSG00000165527
  • Gene Symbol: ATP5MC3 (ENSG00000154518)
    Fold Change: 1.78
    Ensembl ID: ENSG00000154518
  • Gene Symbol: APLP2 (ENSG00000084234)
    Fold Change: 1.76
    Ensembl ID: ENSG00000084234
  • Gene Symbol: CD74 (ENSG00000019582)
    Fold Change: 1.74
    Ensembl ID: ENSG00000019582
  • Gene Symbol: CANX (ENSG00000127022)
    Fold Change: 1.71
    Ensembl ID: ENSG00000127022
  • Gene Symbol: ADD3 (ENSG00000148700)
    Fold Change: 1.7
    Ensembl ID: ENSG00000148700
  • Gene Symbol: CAPZA2 (ENSG00000198898)
    Fold Change: 1.68
    Ensembl ID: ENSG00000198898
  • Gene Symbol: ARF1 (ENSG00000143761)
    Fold Change: 1.67
    Ensembl ID: ENSG00000143761
  • Gene Symbol: AMD1 (ENSG00000123505)
    Fold Change: 1.66
    Ensembl ID: ENSG00000123505
  • Gene Symbol: ATP5PO (ENSG00000241837)
    Fold Change: 1.65
    Ensembl ID: ENSG00000241837
  • Gene Symbol: ATP6V0B (ENSG00000117410)
    Fold Change: 1.61
    Ensembl ID: ENSG00000117410
  • Gene Symbol: CALU (ENSG00000128595)
    Fold Change: 1.6
    Ensembl ID: ENSG00000128595
  • Gene Symbol: SEPTIN7 (ENSG00000122545)
    Fold Change: 1.57
    Ensembl ID: ENSG00000122545
  • Gene Symbol: ATP5F1B (ENSG00000110955)
    Fold Change: 1.57
    Ensembl ID: ENSG00000110955
  • Gene Symbol: CDKN1A (ENSG00000124762)
    Fold Change: 1.47
    Ensembl ID: ENSG00000124762
  • Gene Symbol: DST (ENSG00000151914)
    Fold Change: 1.42
    Ensembl ID: ENSG00000151914
  • Gene Symbol: CAPN2 (ENSG00000162909)
    Fold Change: 1.4
    Ensembl ID: ENSG00000162909
  • Gene Symbol: ATP5MC1 (ENSG00000159199)
    Fold Change: 1.39
    Ensembl ID: ENSG00000159199
  • Gene Symbol: RHOB (ENSG00000143878)
    Fold Change: 1.39
    Ensembl ID: ENSG00000143878
  • Gene Symbol: RHOC (ENSG00000155366)
    Fold Change: 1.39
    Ensembl ID: ENSG00000155366
  • Gene Symbol: ATP1A1 (ENSG00000163399)
    Fold Change: 1.39
    Ensembl ID: ENSG00000163399
  • Gene Symbol: TLE5 (ENSG00000104964)
    Fold Change: 1.38
    Ensembl ID: ENSG00000104964
  • Gene Symbol: CD151 (ENSG00000177697)
    Fold Change: 1.37
    Ensembl ID: ENSG00000177697
  • Gene Symbol: SERPING1 (ENSG00000149131)
    Fold Change: 1.36
    Ensembl ID: ENSG00000149131
  • Gene Symbol: ATOX1 (ENSG00000177556)
    Fold Change: 1.35
    Ensembl ID: ENSG00000177556
  • Gene Symbol: ATF3 (ENSG00000162772)
    Fold Change: 1.33
    Ensembl ID: ENSG00000162772
  • Gene Symbol: CALD1 (ENSG00000122786)
    Fold Change: 1.33
    Ensembl ID: ENSG00000122786
  • Gene Symbol: CAV1 (ENSG00000105974)
    Fold Change: 1.33
    Ensembl ID: ENSG00000105974
  • Gene Symbol: CD70 (ENSG00000125726)
    Fold Change: 1.32
    Ensembl ID: ENSG00000125726
  • Gene Symbol: BNIP3L (ENSG00000104765)
    Fold Change: 1.3
    Ensembl ID: ENSG00000104765
  • Gene Symbol: CAMLG (ENSG00000164615)
    Fold Change: 1.27
    Ensembl ID: ENSG00000164615
  • Gene Symbol: ANXA4 (ENSG00000196975)
    Fold Change: 1.25
    Ensembl ID: ENSG00000196975
  • Gene Symbol: ARL2 (ENSG00000213465)
    Fold Change: 1.24
    Ensembl ID: ENSG00000213465
  • Gene Symbol: ARHGDIA (ENSG00000141522)
    Fold Change: 1.24
    Ensembl ID: ENSG00000141522
  • Gene Symbol: RND3 (ENSG00000115963)
    Fold Change: 1.23
    Ensembl ID: ENSG00000115963
  • Gene Symbol: ARF5 (ENSG00000004059)
    Fold Change: 1.23
    Ensembl ID: ENSG00000004059
  • Gene Symbol: ATP5F1A (ENSG00000152234)
    Fold Change: 1.23
    Ensembl ID: ENSG00000152234
  • Gene Symbol: BAG1 (ENSG00000107262)
    Fold Change: 1.21
    Ensembl ID: ENSG00000107262
  • Gene Symbol: PLIN2 (ENSG00000147872)
    Fold Change: 1.19
    Ensembl ID: ENSG00000147872
  • Gene Symbol: ASAH1 (ENSG00000104763)
    Fold Change: 1.18
    Ensembl ID: ENSG00000104763
  • Gene Symbol: CALM3 (ENSG00000160014)
    Fold Change: 1.18
    Ensembl ID: ENSG00000160014
  • Gene Symbol: ATP5F1C (ENSG00000165629)
    Fold Change: 1.16
    Ensembl ID: ENSG00000165629
  • Gene Symbol: SERPINH1 (ENSG00000149257)
    Fold Change: 1.14
    Ensembl ID: ENSG00000149257
  • Gene Symbol: ACADVL (ENSG00000072778)
    Fold Change: 1.14
    Ensembl ID: ENSG00000072778
  • Gene Symbol: ANXA11 (ENSG00000122359)
    Fold Change: 1.14
    Ensembl ID: ENSG00000122359
  • Gene Symbol: BAD (ENSG00000002330)
    Fold Change: 1.13
    Ensembl ID: ENSG00000002330
  • Gene Symbol: ANXA7 (ENSG00000138279)
    Fold Change: 1.13
    Ensembl ID: ENSG00000138279
  • Gene Symbol: ABL2 (ENSG00000143322)
    Fold Change: 1.12
    Ensembl ID: ENSG00000143322
  • Gene Symbol: CAPZA1 (ENSG00000116489)
    Fold Change: 1.12
    Ensembl ID: ENSG00000116489
  • Gene Symbol: AXL (ENSG00000167601)
    Fold Change: 1.08
    Ensembl ID: ENSG00000167601
  • Gene Symbol: ATP5PB (ENSG00000116459)
    Fold Change: 1.06
    Ensembl ID: ENSG00000116459
  • Gene Symbol: APOD (ENSG00000189058)
    Fold Change: 1.05
    Ensembl ID: ENSG00000189058
  • Gene Symbol: RUNX1 (ENSG00000159216)
    Fold Change: 1.03
    Ensembl ID: ENSG00000159216
  • Gene Symbol: ATRX (ENSG00000085224)
    Fold Change: 1.03
    Ensembl ID: ENSG00000085224
  • Gene Symbol: ATP1B3 (ENSG00000069849)
    Fold Change: 1.03
    Ensembl ID: ENSG00000069849
  • Gene Symbol: C1QBP (ENSG00000108561)
    Fold Change: 1.03
    Ensembl ID: ENSG00000108561
  • Gene Symbol: ASPH (ENSG00000198363)
    Fold Change: 1.02
    Ensembl ID: ENSG00000198363
  • Gene Symbol: CAPG (ENSG00000042493)
    Fold Change: 1.01
    Ensembl ID: ENSG00000042493
  • Gene Symbol: ADM (ENSG00000148926)
    Fold Change: 1
    Ensembl ID: ENSG00000148926
Hovered Details

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Hovered Details

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**Key Characteristics** 1. **Structural Support**: Reticular cells produce collagen and reticular fibers, which provide structural support to tissues, particularly in the spleen, lymph nodes, and kidneys. 2. **Subtypes**: There are three subtypes of reticular cells: epithelial, mesenchymal, and fibroblastic reticular cells, each with distinct functions and localizations. 3. **Collagen Synthesis**: Reticular cells synthesize collagen, which is essential for maintaining tissue architecture. 4. **Actin Cytoskeleton Organization**: The gene symbol ACTB is associated with reticular cells and is involved in actin cytoskeleton organization, cell signaling, and protein localization. 5. **Cell Signaling**: Reticular cells are involved in cell signaling pathways, including those related to immune system development and function. **Clinical Significance** 1. **Immune System Development**: Reticular cells play a crucial role in the development and function of the immune system, particularly in the formation of lymphoid tissues. 2. **Autoimmune Diseases**: Dysfunction or abnormalities in reticular cells have been implicated in autoimmune diseases, such as rheumatoid arthritis and lupus. 3. **Cancer**: Reticular cells can contribute to cancer development and progression by producing collagen and other extracellular matrix components that facilitate tumor growth and metastasis. 4. **Regenerative Medicine**: Understanding the functions and characteristics of reticular cells can inform the development of regenerative therapies for tissue repair and replacement. 5. **Disease Modeling**: Reticular cells can be used as a model system to study disease mechanisms and test potential therapeutic interventions. In conclusion, reticular cells are essential components of the immune system and play a critical role in maintaining tissue architecture and function. Further research into the biology and clinical significance of reticular cells is necessary to fully understand their functions and potential therapeutic applications.