Details for: ARHGDIA

Gene ID: 396

Symbol: ARHGDIA

Ensembl ID: ENSG00000141522

Description: Rho GDP dissociation inhibitor alpha

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 391.0117
    Cell Significance Index: -60.8200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 209.9010
    Cell Significance Index: -53.2400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 160.9549
    Cell Significance Index: -66.3100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 147.1974
    Cell Significance Index: -59.8000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 139.4976
    Cell Significance Index: -65.8600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 131.0010
    Cell Significance Index: -67.3900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 98.2233
    Cell Significance Index: -65.9100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 64.0591
    Cell Significance Index: -61.1600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 51.0075
    Cell Significance Index: -62.8900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 16.4678
    Cell Significance Index: -50.5800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 16.4139
    Cell Significance Index: -64.7700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.3294
    Cell Significance Index: -30.3500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.1703
    Cell Significance Index: -20.0700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 5.1153
    Cell Significance Index: 596.1300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 3.6426
    Cell Significance Index: 106.9800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.5019
    Cell Significance Index: 68.1000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.3284
    Cell Significance Index: 41.1500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.2735
    Cell Significance Index: 169.4400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.2078
    Cell Significance Index: 115.0000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.1910
    Cell Significance Index: 141.3500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.1469
    Cell Significance Index: 39.6800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.9530
    Cell Significance Index: 91.7900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.8357
    Cell Significance Index: 216.4900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.7183
    Cell Significance Index: 235.9700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.6783
    Cell Significance Index: 35.1300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.5898
    Cell Significance Index: 205.4000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.3819
    Cell Significance Index: 169.9200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.3709
    Cell Significance Index: 247.1300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.3176
    Cell Significance Index: 37.7700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.1606
    Cell Significance Index: 114.8100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.0215
    Cell Significance Index: 22.1300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9668
    Cell Significance Index: 50.2200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.9506
    Cell Significance Index: 420.2700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.9473
    Cell Significance Index: 517.3700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.8220
    Cell Significance Index: 7.5700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.7649
    Cell Significance Index: 98.0600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.6855
    Cell Significance Index: 31.9600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.5629
    Cell Significance Index: 39.8100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.5227
    Cell Significance Index: 13.7500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4649
    Cell Significance Index: 93.2600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4065
    Cell Significance Index: 80.6700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.4038
    Cell Significance Index: 4.3900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3860
    Cell Significance Index: 348.4900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3327
    Cell Significance Index: 54.1100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.3090
    Cell Significance Index: 3.5100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2805
    Cell Significance Index: 7.4900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2608
    Cell Significance Index: 44.5300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2561
    Cell Significance Index: 48.7300
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.2083
    Cell Significance Index: 1.7900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1780
    Cell Significance Index: 4.7700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1136
    Cell Significance Index: 40.7400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0501
    Cell Significance Index: 37.8900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0328
    Cell Significance Index: 0.9400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0302
    Cell Significance Index: 1.0600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0047
    Cell Significance Index: 0.0700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0057
    Cell Significance Index: -0.5800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0060
    Cell Significance Index: -0.1000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0187
    Cell Significance Index: -35.2700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0205
    Cell Significance Index: -12.7800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0233
    Cell Significance Index: -17.2800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0248
    Cell Significance Index: -18.2000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0349
    Cell Significance Index: -64.3500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0426
    Cell Significance Index: -65.5600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0497
    Cell Significance Index: -67.5700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0665
    Cell Significance Index: -37.5200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0750
    Cell Significance Index: -3.9400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0755
    Cell Significance Index: -47.9400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0909
    Cell Significance Index: -2.5400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1240
    Cell Significance Index: -56.2800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1433
    Cell Significance Index: -3.3100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1655
    Cell Significance Index: -34.8600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1788
    Cell Significance Index: -1.0800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1797
    Cell Significance Index: -51.7200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.1939
    Cell Significance Index: -21.1000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2204
    Cell Significance Index: -7.6600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2808
    Cell Significance Index: -32.1700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3597
    Cell Significance Index: -52.2900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3754
    Cell Significance Index: -9.5900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.4232
    Cell Significance Index: -19.1800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5188
    Cell Significance Index: -59.2200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.5491
    Cell Significance Index: -36.9200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5898
    Cell Significance Index: -18.8900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6118
    Cell Significance Index: -63.7000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.6544
    Cell Significance Index: -40.2200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6567
    Cell Significance Index: -52.0100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.6890
    Cell Significance Index: -9.4000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.6981
    Cell Significance Index: -53.5700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.7314
    Cell Significance Index: -19.5700
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.7394
    Cell Significance Index: -5.3100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.8781
    Cell Significance Index: -18.7000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.9028
    Cell Significance Index: -56.9000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.9456
    Cell Significance Index: -12.1100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.0426
    Cell Significance Index: -30.7100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -1.0616
    Cell Significance Index: -30.3000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.0741
    Cell Significance Index: -65.8500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.1095
    Cell Significance Index: -62.2600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -1.1384
    Cell Significance Index: -11.7900
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.2367
    Cell Significance Index: -21.3200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.3637
    Cell Significance Index: -60.3200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.4953
    Cell Significance Index: -54.8900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Rho GDP dissociation inhibitor activity**: ARHGDIA is a GDP-dissociation inhibitor (GDI) of Rho GTPases, which are small GTP-binding proteins that regulate various cellular processes. 2. **Regulation of Rho GTPase cycle**: ARHGDIA modulates the activity of Rho GTPases, including RhoA, Rac1, and Rac2, by inhibiting their GDP dissociation. 3. **Cytoskeletal organization**: ARHGDIA regulates cytoskeletal organization and dynamics, particularly in neurons, where it influences axonal growth and morphology. 4. **Immune response**: ARHGDIA is expressed in immune cells, where it modulates signaling pathways involved in immune response, including the regulation of apoptotic processes and the formation of immunological synapses. 5. **Cell migration and proliferation**: ARHGDIA regulates cell migration and proliferation in various cell types, including immune cells and epithelial cells. **Pathways and Functions:** 1. **Axonal growth inhibition**: ARHGDIA regulates axonal growth and morphology in neurons by inhibiting RhoA activation. 2. **Cdc42 GTPase cycle**: ARHGDIA modulates the activity of Cdc42, a Rho GTPase involved in cell migration and cytoskeletal organization. 3. **Cytoskeleton regulation**: ARHGDIA regulates cytoskeletal organization and dynamics in neurons, influencing axonal growth and morphology. 4. **Immune response**: ARHGDIA modulates signaling pathways involved in immune response, including the regulation of apoptotic processes and the formation of immunological synapses. 5. **Signaling by Rho GTPases**: ARHGDIA regulates signaling by Rho GTPases, including RhoA, Rac1, and Rac2, which are involved in various cellular processes. **Clinical Significance:** Dysregulation of ARHGDIA has been implicated in various diseases, including: 1. **Neurodegenerative disorders**: ARHGDIA dysfunction has been linked to neurodegenerative disorders, such as Alzheimer's disease and amyotrophic lateral sclerosis (ALS). 2. **Immune disorders**: ARHGDIA dysfunction has been implicated in immune disorders, such as autoimmune diseases and immunodeficiency disorders. 3. **Cancer**: ARHGDIA overexpression has been observed in certain types of cancer, including breast cancer and colon cancer. 4. **Neurodevelopmental disorders**: ARHGDIA dysfunction has been linked to neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. In conclusion, ARHGDIA is a complex gene that plays a crucial role in various cellular processes, including axonal growth, cytoskeletal organization, and immune response. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the functions and clinical significance of ARHGDIA.

Genular Protein ID: 4098346358

Symbol: GDIR1_HUMAN

Name: Rho GDP-dissociation inhibitor 1

UniProtKB Accession Codes:

P52565 A8MXW0 B2R5X1 B4DDD3 B4DUV9 Q6IBM5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 21 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 21 PDBsum 21 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 9 RefSeq 7 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8262133

Title: Identification of two human Rho GDP dissociation inhibitor proteins whose overexpression leads to disruption of the actin cytoskeleton.

PubMed ID: 8262133

DOI: 10.1006/excr.1993.1298

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8504089

Title: Regulation of the human neutrophil NADPH oxidase by rho-related G-proteins.

PubMed ID: 8504089

DOI: 10.1021/bi00072a029

PubMed ID: 16916647

Title: Substrate and functional diversity of lysine acetylation revealed by a proteomics survey.

PubMed ID: 16916647

DOI: 10.1016/j.molcel.2006.06.026

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21122136

Title: The Fer tyrosine kinase regulates interactions of Rho GDP-Dissociation Inhibitor alpha with the small GTPase Rac.

PubMed ID: 21122136

DOI: 10.1186/1471-2091-11-48

PubMed ID: 20628200

Title: Gankyrin plays an essential role in Ras-induced tumorigenesis through regulation of the RhoA/ROCK pathway in mammalian cells.

PubMed ID: 20628200

DOI: 10.1172/jci42542

PubMed ID: 20400958

Title: Regulation of Rho GTPase crosstalk, degradation and activity by RhoGDI1.

PubMed ID: 20400958

DOI: 10.1038/ncb2049

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25961457

Title: KANK deficiency leads to podocyte dysfunction and nephrotic syndrome.

PubMed ID: 25961457

DOI: 10.1172/jci79504

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 9195882

Title: A modulator of rho family G proteins, rhoGDI, binds these G proteins via an immunoglobulin-like domain and a flexible N-terminal arm.

PubMed ID: 9195882

DOI: 10.1016/s0969-2126(97)00218-9

PubMed ID: 26646181

Title: Structural basis of death domain signaling in the p75 neurotrophin receptor.

PubMed ID: 26646181

DOI: 10.7554/elife.11692

PubMed ID: 23434736

Title: ARHGDIA: a novel gene implicated in nephrotic syndrome.

PubMed ID: 23434736

DOI: 10.1136/jmedgenet-2012-101442

Sequence Information:

  • Length: 204
  • Mass: 23207
  • Checksum: 59CB6F42E3B3BCCA
  • Sequence:
    • MAEQEPTAEQ LAQIAAENEE DEHSVNYKPP AQKSIQEIQE LDKDDESLRK YKEALLGRVA 
VSADPNVPNV VVTGLTLVCS SAPGPLELDL TGDLESFKKQ SFVLKEGVEY RIKISFRVNR 
EIVSGMKYIQ HTYRKGVKID KTDYMVGSYG PRAEEYEFLT PVEEAPKGML ARGSYSIKSR 
FTDDDKTDHL SWEWNLTIKK DWKD

Genular Protein ID: 3620044403

Symbol: J3QQX2_HUMAN

Name: N/A

UniProtKB Accession Codes:

J3QQX2

Database IDs:

ARBA 8 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 1 GeneTree 1 HGNC 1 InterPro 3 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 2 SAM 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16916647

Title: Substrate and functional diversity of lysine acetylation revealed by a proteomics survey.

PubMed ID: 16916647

DOI: 10.1016/j.molcel.2006.06.026

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 235
  • Mass: 25831
  • Checksum: 0E581B31DB84BFCF
  • Sequence:
    • MAEQEPTAEQ LAQIAAENEE DEHSVNYKPP AQKSIQEIQE LDKDDESLRK YKEALLGRVA 
VSADPNVPNV VVTGLTLVCS SAPGPLELDL TGDLESFKKQ SFVLKEGVEY RIKISFRVNR 
EIVSGMKYIQ HTYRKGVKID KTDYMVGSYG PRAEEYEFLT PVEEAPKGSI SPSHPRPGFR 
RERSSHSPGP VVAPGRVRLL LRGGAGVWDA RPRGGRAVLQ PRCSLASPLV AVGPV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.