Details for: ARHGDIA

Gene ID: 396

Symbol: ARHGDIA

Ensembl ID: ENSG00000141522

Description: Rho GDP dissociation inhibitor alpha

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 2.98
    Marker Score: 3601
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.83
    Marker Score: 28036
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.75
    Marker Score: 31981.5
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 2.55
    Marker Score: 8034
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.47
    Marker Score: 138315.5
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.45
    Marker Score: 15641
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.42
    Marker Score: 6684.5
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 2.4
    Marker Score: 10284
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 2.34
    Marker Score: 3385
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.33
    Marker Score: 8999.5
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 2.32
    Marker Score: 1358
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.3
    Marker Score: 4486.5
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.29
    Marker Score: 77873.5
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 2.29
    Marker Score: 6410
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.28
    Marker Score: 5581
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.27
    Marker Score: 1788
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.26
    Marker Score: 119269
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 2.26
    Marker Score: 2180
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.22
    Marker Score: 2544
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.19
    Marker Score: 9459.5
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 2.17
    Marker Score: 1909
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 2.17
    Marker Score: 4549
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.15
    Marker Score: 10584.5
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 2.15
    Marker Score: 6284
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 2.15
    Marker Score: 1812
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.15
    Marker Score: 21801
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 2.14
    Marker Score: 1682
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 2.14
    Marker Score: 2001
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 2.13
    Marker Score: 1286
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 2.13
    Marker Score: 5420
  • Cell Name: Unknown (CL0000548)
    Fold Change: 2.13
    Marker Score: 1550
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.13
    Marker Score: 2387
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.12
    Marker Score: 10189
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.12
    Marker Score: 13512
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.12
    Marker Score: 6646
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.11
    Marker Score: 18485.5
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 2.06
    Marker Score: 2848
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 2.06
    Marker Score: 1830
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.04
    Marker Score: 488
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 2.02
    Marker Score: 2980
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 2.02
    Marker Score: 27173
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.99
    Marker Score: 5902
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.99
    Marker Score: 2929.5
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.98
    Marker Score: 3533.5
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 1.97
    Marker Score: 1440
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.97
    Marker Score: 50349
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.97
    Marker Score: 3851
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 1.96
    Marker Score: 4780
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.95
    Marker Score: 1233
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 1.95
    Marker Score: 1411
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.94
    Marker Score: 1107
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.94
    Marker Score: 2071.5
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.94
    Marker Score: 2575.5
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.94
    Marker Score: 685
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.93
    Marker Score: 790
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.93
    Marker Score: 3067
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.93
    Marker Score: 7891
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.93
    Marker Score: 748
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.92
    Marker Score: 683.5
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.91
    Marker Score: 3230
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.9
    Marker Score: 2068
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.89
    Marker Score: 4703.5
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.89
    Marker Score: 1913.5
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.89
    Marker Score: 1858
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.88
    Marker Score: 3125
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 1.88
    Marker Score: 498
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.87
    Marker Score: 1759
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 1.87
    Marker Score: 1258
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 1.86
    Marker Score: 1527.5
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.86
    Marker Score: 576
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.86
    Marker Score: 1998
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.85
    Marker Score: 1021.5
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.85
    Marker Score: 1855
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1.85
    Marker Score: 1066
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 1.85
    Marker Score: 1021
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 1.85
    Marker Score: 1081.5
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 1.84
    Marker Score: 1990
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.84
    Marker Score: 2153
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 1.84
    Marker Score: 835
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.83
    Marker Score: 943
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.83
    Marker Score: 1724
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.83
    Marker Score: 20564
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.83
    Marker Score: 1838
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.82
    Marker Score: 3166
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.81
    Marker Score: 15613.5
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.8
    Marker Score: 6401
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.8
    Marker Score: 1615
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 1.8
    Marker Score: 474
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.79
    Marker Score: 1355
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.79
    Marker Score: 2532
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 1.79
    Marker Score: 772
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.78
    Marker Score: 613.5
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.77
    Marker Score: 13855
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.77
    Marker Score: 1029
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.76
    Marker Score: 434
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 1.75
    Marker Score: 731
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.75
    Marker Score: 2702
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.74
    Marker Score: 352
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 1.74
    Marker Score: 495
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 1.74
    Marker Score: 491

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Other Information

**Key characteristics:** * ARHGDIA is a single-pass membrane protein with a molecular weight of approximately 130 kDa. * It is a member of the Rho GDP-dissociation inhibitor (RGD) family of proteins. * It is expressed in a variety of cell types, including myeloid and lymphoid cells, and is particularly abundant in macrophages and dendritic cells. * It is a key regulator of axonogenesis, promoting the survival and migration of neural stem cells and promoting the growth and survival of neurons. * It is also involved in cell migration, proliferation, and differentiation. **Pathways and functions:** * ARHGDIA is a key regulator of axonogenesis by promoting the survival and migration of neural stem cells. * It does this by binding to Rho GTPases and inhibiting their activity, which leads to the stabilization of the Rho GDP-bound form of ARHGDIA. * This allows ARHGDIA to translocate to the cell surface and interact with its targets, including Rho GTPases. * Once bound, ARHGDIA prevents the GTPases from interacting with their substrates, which leads to the inhibition of Rho-mediated signaling pathways. * This results in the survival and migration of neural stem cells. **Clinical significance:** * Mutations in the ARHGDIA gene have been linked to several human diseases, including autism, schizophrenia, and cancer. * These mutations can lead to the loss of ARHGDIA function, which can result in neuronal apoptosis, cell migration, and tumor growth. * Therefore, ARHGDIA is a promising target for the treatment of neurodegenerative diseases.

Genular Protein ID: 4098346358

Symbol: GDIR1_HUMAN

Name: Rho GDP-dissociation inhibitor 1

UniProtKB Accession Codes:

P52565 A8MXW0 B2R5X1 B4DDD3 B4DUV9 Q6IBM5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DOSAC-COBS-2DPAGE 1 DisGeNET 1 ELM 1 EMBL 21 EPD 1 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 24 PDBsum 20 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 9 RefSeq 7 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8262133

Title: Identification of two human Rho GDP dissociation inhibitor proteins whose overexpression leads to disruption of the actin cytoskeleton.

PubMed ID: 8262133

DOI: 10.1006/excr.1993.1298

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8504089

Title: Regulation of the human neutrophil NADPH oxidase by rho-related G-proteins.

PubMed ID: 8504089

DOI: 10.1021/bi00072a029

PubMed ID: 16916647

Title: Substrate and functional diversity of lysine acetylation revealed by a proteomics survey.

PubMed ID: 16916647

DOI: 10.1016/j.molcel.2006.06.026

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21122136

Title: The Fer tyrosine kinase regulates interactions of Rho GDP-Dissociation Inhibitor alpha with the small GTPase Rac.

PubMed ID: 21122136

DOI: 10.1186/1471-2091-11-48

PubMed ID: 20628200

Title: Gankyrin plays an essential role in Ras-induced tumorigenesis through regulation of the RhoA/ROCK pathway in mammalian cells.

PubMed ID: 20628200

DOI: 10.1172/jci42542

PubMed ID: 20400958

Title: Regulation of Rho GTPase crosstalk, degradation and activity by RhoGDI1.

PubMed ID: 20400958

DOI: 10.1038/ncb2049

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25961457

Title: KANK deficiency leads to podocyte dysfunction and nephrotic syndrome.

PubMed ID: 25961457

DOI: 10.1172/jci79504

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 9195882

Title: A modulator of rho family G proteins, rhoGDI, binds these G proteins via an immunoglobulin-like domain and a flexible N-terminal arm.

PubMed ID: 9195882

DOI: 10.1016/s0969-2126(97)00218-9

PubMed ID: 26646181

Title: Structural basis of death domain signaling in the p75 neurotrophin receptor.

PubMed ID: 26646181

DOI: 10.7554/elife.11692

PubMed ID: 23434736

Title: ARHGDIA: a novel gene implicated in nephrotic syndrome.

PubMed ID: 23434736

DOI: 10.1136/jmedgenet-2012-101442

Sequence Information:

  • Length: 204
  • Mass: 23207
  • Checksum: 59CB6F42E3B3BCCA
  • Sequence:
    • MAEQEPTAEQ LAQIAAENEE DEHSVNYKPP AQKSIQEIQE LDKDDESLRK YKEALLGRVA 
VSADPNVPNV VVTGLTLVCS SAPGPLELDL TGDLESFKKQ SFVLKEGVEY RIKISFRVNR 
EIVSGMKYIQ HTYRKGVKID KTDYMVGSYG PRAEEYEFLT PVEEAPKGML ARGSYSIKSR 
FTDDDKTDHL SWEWNLTIKK DWKD

Genular Protein ID: 3620044403

Symbol: J3QQX2_HUMAN

Name: N/A

UniProtKB Accession Codes:

J3QQX2

Database IDs:

ARBA 8 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 1 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 3 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 Pfam 1 Proteomes 2 RefSeq 2 SAM 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 16916647

Title: Substrate and functional diversity of lysine acetylation revealed by a proteomics survey.

PubMed ID: 16916647

DOI: 10.1016/j.molcel.2006.06.026

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 235
  • Mass: 25831
  • Checksum: 0E581B31DB84BFCF
  • Sequence:
    • MAEQEPTAEQ LAQIAAENEE DEHSVNYKPP AQKSIQEIQE LDKDDESLRK YKEALLGRVA 
VSADPNVPNV VVTGLTLVCS SAPGPLELDL TGDLESFKKQ SFVLKEGVEY RIKISFRVNR 
EIVSGMKYIQ HTYRKGVKID KTDYMVGSYG PRAEEYEFLT PVEEAPKGSI SPSHPRPGFR 
RERSSHSPGP VVAPGRVRLL LRGGAGVWDA RPRGGRAVLQ PRCSLASPLV AVGPV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.