Details for: CD74

Gene ID: 972

Symbol: CD74

Ensembl ID: ENSG00000019582

Description: CD74 molecule

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 621.8770
    Cell Significance Index: -96.7300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 255.9949
    Cell Significance Index: -131.6800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 241.0391
    Cell Significance Index: -113.8000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 179.3463
    Cell Significance Index: -45.4900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 169.3834
    Cell Significance Index: -113.6600
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 131.5966
    Cell Significance Index: 547.7000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 78.1455
    Cell Significance Index: -96.3500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 40.5345
    Cell Significance Index: -124.5000
  • Cell Name: centroblast (CL0009112)
    Fold Change: 36.7285
    Cell Significance Index: 85.6900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 27.3844
    Cell Significance Index: -108.0600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 22.9165
    Cell Significance Index: -61.3900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 22.9143
    Cell Significance Index: -50.1500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 18.4530
    Cell Significance Index: 341.0600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 14.4752
    Cell Significance Index: 255.8000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 12.8989
    Cell Significance Index: 1521.1700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 10.6947
    Cell Significance Index: 314.0900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 10.3385
    Cell Significance Index: 117.4500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 7.7152
    Cell Significance Index: 497.7500
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 7.2853
    Cell Significance Index: 32.5800
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 7.1485
    Cell Significance Index: 51.3400
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 6.8087
    Cell Significance Index: 45.1700
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 6.4477
    Cell Significance Index: 110.7700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 4.9239
    Cell Significance Index: 113.7600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 4.6977
    Cell Significance Index: 72.6800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 4.3063
    Cell Significance Index: 115.1900
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 2.6756
    Cell Significance Index: 17.0800
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 2.6000
    Cell Significance Index: 9.6900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.1945
    Cell Significance Index: 103.1400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 2.1846
    Cell Significance Index: 1653.5300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.1670
    Cell Significance Index: 266.4600
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 2.0083
    Cell Significance Index: 5.3800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.6516
    Cell Significance Index: 297.7400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.5686
    Cell Significance Index: 856.6600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.5456
    Cell Significance Index: 199.6800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.4584
    Cell Significance Index: 1316.7900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8744
    Cell Significance Index: 173.5200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7233
    Cell Significance Index: 43.4200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.5282
    Cell Significance Index: 13.8900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3771
    Cell Significance Index: 61.3300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3263
    Cell Significance Index: 35.5000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3254
    Cell Significance Index: 32.1900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.3067
    Cell Significance Index: 31.3300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2861
    Cell Significance Index: 126.4900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0200
    Cell Significance Index: 2.5700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0150
    Cell Significance Index: 2.8600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0466
    Cell Significance Index: -87.6900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0730
    Cell Significance Index: -134.6700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0846
    Cell Significance Index: -130.2700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0861
    Cell Significance Index: -53.7700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0981
    Cell Significance Index: -72.6400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0984
    Cell Significance Index: -133.7300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.1185
    Cell Significance Index: -86.9000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1312
    Cell Significance Index: -22.4100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1666
    Cell Significance Index: -93.9400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1916
    Cell Significance Index: -121.7000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.2681
    Cell Significance Index: -121.6900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2736
    Cell Significance Index: -12.4000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2839
    Cell Significance Index: -21.1600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.2922
    Cell Significance Index: -104.8100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3085
    Cell Significance Index: -7.8800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.3145
    Cell Significance Index: -90.4800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3400
    Cell Significance Index: -71.6100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3485
    Cell Significance Index: -17.6100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.3657
    Cell Significance Index: -12.8500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.4288
    Cell Significance Index: -58.8800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4883
    Cell Significance Index: -56.9100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.4891
    Cell Significance Index: -98.1100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.7035
    Cell Significance Index: -80.6000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.7771
    Cell Significance Index: -31.8400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.8021
    Cell Significance Index: -116.5900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.8405
    Cell Significance Index: -95.9400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.9551
    Cell Significance Index: -30.5900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.9718
    Cell Significance Index: -28.0000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.0367
    Cell Significance Index: -107.9500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.1573
    Cell Significance Index: -28.9300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.2602
    Cell Significance Index: -96.7100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -1.3745
    Cell Significance Index: -71.4000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -1.4606
    Cell Significance Index: -40.8200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.5099
    Cell Significance Index: -92.5700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -1.6011
    Cell Significance Index: -113.2400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.6255
    Cell Significance Index: -128.7400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -1.6421
    Cell Significance Index: -85.5400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -1.6504
    Cell Significance Index: -76.9500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.7428
    Cell Significance Index: -117.1900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -2.0009
    Cell Significance Index: -126.1100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -2.0210
    Cell Significance Index: -124.2200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -2.0901
    Cell Significance Index: -56.8900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -2.1944
    Cell Significance Index: -123.1400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -2.2219
    Cell Significance Index: -116.6600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -2.4838
    Cell Significance Index: -53.8100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -2.5642
    Cell Significance Index: -94.1300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -2.6138
    Cell Significance Index: -90.8300
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -2.6400
    Cell Significance Index: -45.5100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -2.6597
    Cell Significance Index: -117.6500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -2.7469
    Cell Significance Index: -41.1600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -2.7982
    Cell Significance Index: -82.4200
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -2.8556
    Cell Significance Index: -30.3400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -3.0850
    Cell Significance Index: -44.3700
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -3.0850
    Cell Significance Index: -64.3400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -3.1048
    Cell Significance Index: -117.5700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

Key Characteristics

CD74 is a type II transmembrane protein with a molecular weight of approximately 55 kDa. It is composed of three domains: the extracellular domain, the transmembrane domain, and the intracellular domain. The extracellular domain contains a binding site for MHC class II molecules, while the intracellular domain interacts with chaperone proteins to facilitate protein refolding and antigen processing. CD74 is also known to interact with various signaling molecules, including cytokines, chemokines, and growth factors, which modulate immune responses.

Pathways and Functions

CD74 is involved in various cellular processes, including:

  1. Antigen processing and presentation: CD74 associates with MHC class II molecules, facilitating their processing and presentation of antigens to T-cells.
  2. Immune system regulation: CD74 modulates T-cell activation, proliferation, and differentiation, as well as the production of cytokines and chemokines.
  3. Cell surface interactions: CD74 interacts with various ligands, including cytokines, chemokines, and growth factors, which regulate immune responses.
  4. Protein refolding and chaperone activity: CD74 acts as a chaperone cofactor-dependent protein refolding protein, facilitating the proper folding of MHC class II molecules and other proteins.
  5. Apoptosis regulation: CD74 negatively regulates apoptosis in B cells and other cells, promoting cell survival and immune responses.

Clinical Significance

CD74 is of significant clinical interest due to its role in immune system regulation. Dysregulation of CD74 has been implicated in various diseases, including:

  1. Autoimmune disorders: CD74 dysfunction has been linked to autoimmune diseases, such as rheumatoid arthritis and lupus.
  2. Cancer: CD74 has been identified as a tumor antigen in certain cancers, including breast, lung, and colon cancer.
  3. Infectious diseases: CD74 plays a critical role in the immune response to infections, such as HIV and tuberculosis.
  4. Immunotherapies: CD74-targeting therapies have been developed to modulate immune responses in cancer and autoimmune diseases.

In conclusion, CD74 is a multifunctional protein that plays a crucial role in the adaptive immune system. Its dysregulation has been implicated in various diseases, and targeting CD74 has emerged as a promising therapeutic strategy for immune-related disorders.

Genular Protein ID: 620536413

Symbol: HG2A_HUMAN

Name: HLA-DR antigens-associated invariant chain

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 6324166

Title: cDNA clone for the human invariant gamma chain of class II histocompatibility antigens and its implications for the protein structure.

PubMed ID: 6324166

DOI: 10.1073/pnas.80.24.7395

PubMed ID: 6586420

Title: The complete sequence of the mRNA for the HLA-DR-associated invariant chain reveals a polypeptide with an unusual transmembrane polarity.

PubMed ID: 6586420

DOI: 10.1002/j.1460-2075.1984.tb01898.x

PubMed ID: 3001652

Title: Structure of the human gene encoding the invariant gamma-chain of class II histocompatibility antigens.

PubMed ID: 3001652

DOI: 10.1093/nar/13.24.8827

PubMed ID: 3459184

Title: Structure of the human Ia-associated invariant (gamma)-chain gene: identification of 5' sequences shared with major histocompatibility complex class II genes.

PubMed ID: 3459184

DOI: 10.1073/pnas.83.12.4484

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1448172

Title: HLA-DR molecules from an antigen-processing mutant cell line are associated with invariant chain peptides.

PubMed ID: 1448172

DOI: 10.1038/360474a0

PubMed ID: 3104027

Title: Alternative splicing and alternative initiation of translation explain the four forms of the Ia antigen-associated invariant chain.

PubMed ID: 3104027

DOI: 10.1002/j.1460-2075.1986.tb04673.x

PubMed ID: 12661006

Title: Fusion of FIG to the receptor tyrosine kinase ROS in a glioblastoma with an interstitial del(6)(q21q21).

PubMed ID: 12661006

DOI: 10.1002/gcc.10207

PubMed ID: 12782713

Title: MIF signal transduction initiated by binding to CD74.

PubMed ID: 12782713

DOI: 10.1084/jem.20030286

PubMed ID: 19092054

Title: MHC class II transport at a glance.

PubMed ID: 19092054

DOI: 10.1242/jcs.035089

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22171320

Title: Human urinary glycoproteomics; attachment site specific analysis of N- and O-linked glycosylations by CID and ECD.

PubMed ID: 22171320

DOI: 10.1074/mcp.m111.013649

PubMed ID: 23234360

Title: LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins.

PubMed ID: 23234360

DOI: 10.1021/pr300963h

PubMed ID: 25326458

Title: Identification of chondroitin sulfate linkage region glycopeptides reveals prohormones as a novel class of proteoglycans.

PubMed ID: 25326458

DOI: 10.1074/mcp.m114.043703

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 32337544

Title: An affinity chromatography and glycoproteomics workflow to profile the chondroitin sulfate proteoglycans that interact with malarial VAR2CSA in the placenta and in cancer.

PubMed ID: 32337544

DOI: 10.1093/glycob/cwaa039

PubMed ID: 32855215

Title: MHC class II transactivator CIITA induces cell resistance to Ebola virus and SARS-like coronaviruses.

PubMed ID: 32855215

DOI: 10.1126/science.abb3753

PubMed ID: 36213313

Title: Mass spectrometric analysis of chondroitin sulfate-linked peptides.

PubMed ID: 36213313

DOI: 10.1007/s42485-022-00092-3

PubMed ID: 37453717

Title: Mapping the Human Chondroitin Sulfate Glycoproteome Reveals an Unexpected Correlation Between Glycan Sulfation and Attachment Site Characteristics.

PubMed ID: 37453717

DOI: 10.1016/j.mcpro.2023.100617

PubMed ID: 7477400

Title: The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3.

PubMed ID: 7477400

DOI: 10.1038/378457a0

PubMed ID: 9843486

Title: Structure of a trimeric domain of the MHC class II-associated chaperonin and targeting protein Ii.

PubMed ID: 9843486

DOI: 10.1093/emboj/17.23.6812

PubMed ID: 10022822

Title: Crystal structure of MHC class II-associated p41 Ii fragment bound to cathepsin L reveals the structural basis for differentiation between cathepsins L and S.

PubMed ID: 10022822

DOI: 10.1093/emboj/18.4.793

Sequence Information:

  • Length: 296
  • Mass: 33516
  • Checksum: 27A13F252D5FB91D
  • Sequence:
  • MHRRRSRSCR EDQKPVMDDQ RDLISNNEQL PMLGRRPGAP ESKCSRGALY TGFSILVTLL 
    LAGQATTAYF LYQQQGRLDK LTVTSQNLQL ENLRMKLPKP PKPVSKMRMA TPLLMQALPM 
    GALPQGPMQN ATKYGNMTED HVMHLLQNAD PLKVYPPLKG SFPENLRHLK NTMETIDWKV 
    FESWMHHWLL FEMSRHSLEQ KPTDAPPKVL TKCQEEVSHI PAVHPGSFRP KCDENGNYLP 
    LQCYGSIGYC WCVFPNGTEV PNTRSRGHHN CSESLELEDP SSGLGVTKQD LGPVPM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.