Details for: ARL2

Gene ID: 402

Symbol: ARL2

Ensembl ID: ENSG00000213465

Description: ADP ribosylation factor like GTPase 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.27
    Marker Score: 4610
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.26
    Marker Score: 2730
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.22
    Marker Score: 9589
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.21
    Marker Score: 4406.5
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.12
    Marker Score: 3521
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 2.09
    Marker Score: 2182
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 2.06
    Marker Score: 1947
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 2.04
    Marker Score: 2951
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 2.01
    Marker Score: 4931
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.96
    Marker Score: 7706
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.94
    Marker Score: 7176
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.93
    Marker Score: 3105
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.91
    Marker Score: 5000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.88
    Marker Score: 7707
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.86
    Marker Score: 6608
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.84
    Marker Score: 1966
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.84
    Marker Score: 1308
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.82
    Marker Score: 4273
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.77
    Marker Score: 3701
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.76
    Marker Score: 8644
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.74
    Marker Score: 15281
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.73
    Marker Score: 399
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.73
    Marker Score: 1171.5
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.7
    Marker Score: 3014
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.69
    Marker Score: 1226
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.67
    Marker Score: 1695
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.64
    Marker Score: 1735
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1.64
    Marker Score: 369
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.63
    Marker Score: 1971
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.63
    Marker Score: 18316.5
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 1.62
    Marker Score: 459
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.62
    Marker Score: 2575
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.61
    Marker Score: 2279
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.58
    Marker Score: 2676
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 1.58
    Marker Score: 2059
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.57
    Marker Score: 808
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.56
    Marker Score: 501
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.55
    Marker Score: 550
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.54
    Marker Score: 39411
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.53
    Marker Score: 4176
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 1.52
    Marker Score: 3874
  • Cell Name: basophil (CL0000767)
    Fold Change: 1.52
    Marker Score: 723
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 1.51
    Marker Score: 1522
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.51
    Marker Score: 2563.5
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.5
    Marker Score: 604
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.49
    Marker Score: 941
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.47
    Marker Score: 2771
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.47
    Marker Score: 9585
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.46
    Marker Score: 2011
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.45
    Marker Score: 3665
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.45
    Marker Score: 3309
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.45
    Marker Score: 6965
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.44
    Marker Score: 1621
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.43
    Marker Score: 951.5
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.42
    Marker Score: 303
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.42
    Marker Score: 1220
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.41
    Marker Score: 3782
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.41
    Marker Score: 473
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.38
    Marker Score: 11879.5
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.36
    Marker Score: 2009.5
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 1.35
    Marker Score: 315
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.34
    Marker Score: 1954
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.33
    Marker Score: 1386.5
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.33
    Marker Score: 46139
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.31
    Marker Score: 316
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.31
    Marker Score: 859
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 1.3
    Marker Score: 565
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.3
    Marker Score: 1396
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.29
    Marker Score: 713
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.29
    Marker Score: 291
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.29
    Marker Score: 488
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 1.29
    Marker Score: 475
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.28
    Marker Score: 317
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.28
    Marker Score: 2903
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.27
    Marker Score: 494
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.27
    Marker Score: 444
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.26
    Marker Score: 720
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.26
    Marker Score: 890
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.26
    Marker Score: 1135
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.25
    Marker Score: 397
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 1.25
    Marker Score: 781
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.25
    Marker Score: 470
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.25
    Marker Score: 7575
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 1.24
    Marker Score: 454
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.23
    Marker Score: 1163
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 1.23
    Marker Score: 932
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.22
    Marker Score: 9564.5
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.22
    Marker Score: 1873
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.21
    Marker Score: 1087
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 1.21
    Marker Score: 1169
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.21
    Marker Score: 2865
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 1.21
    Marker Score: 291
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.2
    Marker Score: 7679
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.2
    Marker Score: 1845
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.19
    Marker Score: 1122.5
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.18
    Marker Score: 1250
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.18
    Marker Score: 1240
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 1.17
    Marker Score: 344
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 1.17
    Marker Score: 265
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 1.17
    Marker Score: 782

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Other Information

**Key characteristics:** - ARL2 is a protein of the ADP-ribosylation factor like GTPase family. - It is highly expressed in GABAergic amacrine cell, glycinergic neuron, decidual cell, endothelial cell of uterus, kidney collecting duct intercalated cell, erythroid progenitor cell, and alveolar capillary type 2 endothelial cell. - It is involved in the centrosome cycle, Gdp binding, Gtpase activity, and regulation of glycolytic process. **Pathways and functions:** - ARL2 is involved in the centrosome cycle, where it is involved in the regulation of cell cycle progression. - It is also involved in Gdp binding, Gtpase activity, and regulation of glycolytic process. - It is involved in the regulation of the Gdp/ppGdp ratio, which is a measure of cellular energy status. - It is also involved in the regulation of the cell cycle and apoptosis. **Clinical significance:** - Mutations in the ARL2 gene have been linked to several human diseases, including cancer and neurodegenerative disorders. - ARL2 inhibitors are being investigated as potential treatments for these diseases.

Genular Protein ID: 2111126002

Symbol: ARL2_HUMAN

Name: ADP-ribosylation factor-like protein 2

UniProtKB Accession Codes:

P36404 G3V184 Q9BUK8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChEBI 4 ChEMBL 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 26 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 2 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 3 RefSeq 2 SMART 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8415637

Title: Selective amplification of additional members of the ADP-ribosylation factor (ARF) family: cloning of additional human and Drosophila ARF-like genes.

PubMed ID: 8415637

DOI: 10.1073/pnas.90.19.8952

PubMed ID: 15146197

Title: Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.

PubMed ID: 15146197

DOI: 10.1038/nbt971

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10488091

Title: The ARF-like 2 (ARL2)-binding protein, BART. Purification, cloning, and initial characterization.

PubMed ID: 10488091

DOI: 10.1074/jbc.274.39.27553

PubMed ID: 10831612

Title: ADP ribosylation factor-like protein 2 (Arl2) regulates the interaction of tubulin-folding cofactor D with native tubulin.

PubMed ID: 10831612

DOI: 10.1083/jcb.149.5.1087

PubMed ID: 11303027

Title: ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins.

PubMed ID: 11303027

DOI: 10.1074/jbc.m102359200

PubMed ID: 11847227

Title: Functional overlap between retinitis pigmentosa 2 protein and the tubulin-specific chaperone cofactor C.

PubMed ID: 11847227

DOI: 10.1074/jbc.m200128200

PubMed ID: 11809823

Title: ARL2 and BART enter mitochondria and bind the adenine nucleotide transporter.

PubMed ID: 11809823

DOI: 10.1091/mbc.01-05-0245

PubMed ID: 16525022

Title: Arl2 and Arl3 regulate different microtubule-dependent processes.

PubMed ID: 16525022

DOI: 10.1091/mbc.e05-10-0929

PubMed ID: 17452337

Title: ELMOD2 is an Arl2 GTPase-activating protein that also acts on Arfs.

PubMed ID: 17452337

DOI: 10.1074/jbc.m701347200

PubMed ID: 18588884

Title: Specificity of Arl2/Arl3 signaling is mediated by a ternary Arl3-effector-GAP complex.

PubMed ID: 18588884

DOI: 10.1016/j.febslet.2008.05.053

PubMed ID: 18234692

Title: BART is essential for nuclear retention of STAT3.

PubMed ID: 18234692

DOI: 10.1093/intimm/dxm154

PubMed ID: 18981177

Title: The structure of binder of Arl2 (BART) reveals a novel G protein binding domain: implications for function.

PubMed ID: 18981177

DOI: 10.1074/jbc.m806167200

PubMed ID: 20740604

Title: Effect of TBCD and its regulatory interactor Arl2 on tubulin and microtubule integrity.

PubMed ID: 20740604

DOI: 10.1002/cm.20480

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 27666374

Title: Biallelic TBCD mutations cause early-onset neurodegenerative encephalopathy.

PubMed ID: 27666374

DOI: 10.1016/j.ajhg.2016.08.005

PubMed ID: 30945270

Title: Whole-exome sequencing identified ARL2 as a novel candidate gene for MRCS (microcornea, rod-cone dystrophy, cataract, and posterior staphyloma) syndrome.

PubMed ID: 30945270

DOI: 10.1111/cge.13541

PubMed ID: 19368893

Title: Crystal structure of the ARL2-GTP-BART complex reveals a novel recognition and binding mode of small GTPase with effector.

PubMed ID: 19368893

DOI: 10.1016/j.str.2009.01.014

Sequence Information:

  • Length: 184
  • Mass: 20878
  • Checksum: 0823F005719C17F9
  • Sequence:
    • MGLLTILKKM KQKERELRLL MLGLDNAGKT TILKKFNGED IDTISPTLGF NIKTLEHRGF 
KLNIWDVGGQ KSLRSYWRNY FESTDGLIWV VDSADRQRMQ DCQRELQSLL VEERLAGATL 
LIFANKQDLP GALSSNAIRE VLELDSIRSH HWCIQGCSAV TGENLLPGID WLLDDISSRI 
FTAD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.