Details for: CAPZA1

Gene ID: 829

Symbol: CAPZA1

Ensembl ID: ENSG00000116489

Description: capping actin protein of muscle Z-line subunit alpha 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 439.6631
    Cell Significance Index: -68.3900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 265.5303
    Cell Significance Index: -67.3500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 192.5488
    Cell Significance Index: -79.3200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 173.7200
    Cell Significance Index: -70.5800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 170.9090
    Cell Significance Index: -80.6900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 153.7175
    Cell Significance Index: -79.0700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 74.8788
    Cell Significance Index: -71.4900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 62.4880
    Cell Significance Index: -77.0500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 26.3918
    Cell Significance Index: -70.7000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 20.0251
    Cell Significance Index: -79.0200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 19.7919
    Cell Significance Index: -60.7900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 17.6369
    Cell Significance Index: -38.6000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 3.0103
    Cell Significance Index: 80.3800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 2.1117
    Cell Significance Index: 54.2800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.0510
    Cell Significance Index: 60.2400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 2.0507
    Cell Significance Index: 223.0500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.7318
    Cell Significance Index: 204.2300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.6704
    Cell Significance Index: 22.7900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.6641
    Cell Significance Index: 299.9800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.6399
    Cell Significance Index: 201.6400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.5669
    Cell Significance Index: 28.9600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.4289
    Cell Significance Index: 286.6300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.2045
    Cell Significance Index: 239.0400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.1128
    Cell Significance Index: 31.1000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.0505
    Cell Significance Index: 573.7100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.0399
    Cell Significance Index: 142.8100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.9634
    Cell Significance Index: 62.1600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.8967
    Cell Significance Index: 42.1500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.8031
    Cell Significance Index: 41.8300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7943
    Cell Significance Index: 351.1900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7433
    Cell Significance Index: 120.8900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7222
    Cell Significance Index: 259.0400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.6121
    Cell Significance Index: 46.9700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5571
    Cell Significance Index: 12.0700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4908
    Cell Significance Index: 93.4000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3390
    Cell Significance Index: 234.4900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2867
    Cell Significance Index: 28.3700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2800
    Cell Significance Index: 15.7100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1973
    Cell Significance Index: 14.7100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1723
    Cell Significance Index: 22.2600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1716
    Cell Significance Index: 323.0500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1666
    Cell Significance Index: 11.7800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1533
    Cell Significance Index: 236.0700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1128
    Cell Significance Index: 208.0800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1093
    Cell Significance Index: 6.7200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1013
    Cell Significance Index: 12.9800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1010
    Cell Significance Index: 64.1700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0726
    Cell Significance Index: 12.3900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0219
    Cell Significance Index: 9.9300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0215
    Cell Significance Index: 29.2900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0049
    Cell Significance Index: -0.0500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0255
    Cell Significance Index: -15.9100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0271
    Cell Significance Index: -1.4100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0284
    Cell Significance Index: -21.5300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0379
    Cell Significance Index: -0.6400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0404
    Cell Significance Index: -1.4200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0479
    Cell Significance Index: -35.5000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0612
    Cell Significance Index: -0.3700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0651
    Cell Significance Index: -9.4700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0798
    Cell Significance Index: -58.4900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0929
    Cell Significance Index: -52.3900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1004
    Cell Significance Index: -4.6800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1323
    Cell Significance Index: -13.5100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2179
    Cell Significance Index: -45.9000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2346
    Cell Significance Index: -4.0200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2412
    Cell Significance Index: -69.4100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3393
    Cell Significance Index: -11.7900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3453
    Cell Significance Index: -9.4000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4009
    Cell Significance Index: -46.7300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4602
    Cell Significance Index: -52.7200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4807
    Cell Significance Index: -32.3300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5069
    Cell Significance Index: -14.5300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.5212
    Cell Significance Index: -13.9700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5534
    Cell Significance Index: -63.1700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5878
    Cell Significance Index: -61.2000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.5908
    Cell Significance Index: -15.5400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.6903
    Cell Significance Index: -43.5100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.7370
    Cell Significance Index: -32.6000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.7448
    Cell Significance Index: -15.5900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.8651
    Cell Significance Index: -22.1000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.8923
    Cell Significance Index: -33.7900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.9048
    Cell Significance Index: -71.6600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.9447
    Cell Significance Index: -49.6000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.9911
    Cell Significance Index: -28.5600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.1724
    Cell Significance Index: -37.5500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -1.1914
    Cell Significance Index: -17.5900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -1.3032
    Cell Significance Index: -25.4400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.3101
    Cell Significance Index: -80.3200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -1.3363
    Cell Significance Index: -15.9300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.3761
    Cell Significance Index: -36.8100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -1.3820
    Cell Significance Index: -69.8400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -1.3822
    Cell Significance Index: -62.6500
  • Cell Name: peg cell (CL4033014)
    Fold Change: -1.4284
    Cell Significance Index: -33.0000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.4322
    Cell Significance Index: -35.8000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -1.5423
    Cell Significance Index: -37.6300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -1.6441
    Cell Significance Index: -39.4300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.6880
    Cell Significance Index: -49.7200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.7196
    Cell Significance Index: -56.3000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.7238
    Cell Significance Index: -54.9000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.7861
    Cell Significance Index: -62.5700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Gene Expression**: CAPZA1 is highly expressed in immune cells, suggesting its role in immune function and regulation. 2. **Protein Structure**: The alpha subunit of the CAP protein is a globular domain-containing protein, which interacts with the beta subunit to form the F-actin capping protein complex. 3. **Function**: The CAP protein complex regulates actin polymerization and depolymerization, which is essential for maintaining cellular homeostasis and function. 4. **Cellular Localization**: The CAP protein complex is primarily localized to the cytoskeleton, where it regulates actin filament dynamics. **Pathways and Functions** 1. **Actin Cytoskeleton Organization**: CAPZA1 plays a crucial role in regulating actin polymerization and depolymerization, which is essential for maintaining cellular homeostasis and function. 2. **Adaptive Immune Response**: The CAP protein complex is involved in regulating immune cell function, including cell signaling, migration, and adhesion. 3. **Cell Signaling**: CAPZA1 interacts with various signaling molecules, including cytokines and growth factors, to regulate cellular responses to stimuli. 4. **Cellular Responses to Stress**: The CAP protein complex is involved in regulating cellular responses to stress, including heat shock and oxidative stress. 5. **Vesicle-Mediated Transport**: CAPZA1 is involved in regulating vesicle-mediated transport, including endocytosis and exocytosis. **Clinical Significance** 1. **Immune Dysfunction**: Alterations in CAPZA1 expression or function may contribute to immune dysfunction, including autoimmune diseases and immunodeficiency disorders. 2. **Cancer**: The CAP protein complex is involved in regulating cell migration and invasion, which are critical processes in cancer development and progression. 3. **Neurological Disorders**: Alterations in CAPZA1 expression or function may contribute to neurological disorders, including Alzheimer's disease and Parkinson's disease. 4. **Infectious Diseases**: The CAP protein complex is involved in regulating immune cell function, which is essential for controlling infectious diseases. In conclusion, the CAPZA1 gene plays a crucial role in regulating actin polymerization and depolymerization, which is essential for maintaining cellular homeostasis and function. Its involvement in multiple cellular pathways, including immune function, cell signaling, and cellular responses to stress, highlights its importance in maintaining cellular homeostasis and function. Further research is necessary to fully elucidate the role of CAPZA1 in human health and disease.

Genular Protein ID: 1572380775

Symbol: CAZA1_HUMAN

Name: F-actin-capping protein subunit alpha-1

UniProtKB Accession Codes:

P52907 Q53FQ6 Q6FHD5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DNASU 1 DisGeNET 1 EMBL 8 EMDB 1 Ensembl 1 EvolutionaryTrace 1 GO 15 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 2 RNAct 1 Reactome 8 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9331217

Title: Vertebrates have conserved capping protein alpha isoforms with specific expression patterns.

PubMed ID: 9331217

DOI: 10.1002/(sici)1097-0169(1997)38:2<120::aid-cm2>3.0.co;2-b

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19922875

Title: The Arp2/3 activator WASH controls the fission of endosomes through a large multiprotein complex.

PubMed ID: 19922875

DOI: 10.1016/j.devcel.2009.09.010

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22891260

Title: Epithelial junction formation requires confinement of Cdc42 activity by a novel SH3BP1 complex.

PubMed ID: 22891260

DOI: 10.1083/jcb.201202094

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 30361697

Title: Deregulation of CRAD-controlled cytoskeleton initiates mucinous colorectal cancer via beta-catenin.

PubMed ID: 30361697

DOI: 10.1038/s41556-018-0215-z

PubMed ID: 24951542

Title: A missense mutation in the PISA domain of HsSAS-6 causes autosomal recessive primary microcephaly in a large consanguineous Pakistani family.

PubMed ID: 24951542

DOI: 10.1093/hmg/ddu318

PubMed ID: 12470955

Title: Solution NMR structure of S100B bound to the high-affinity target peptide TRTK-12.

PubMed ID: 12470955

DOI: 10.1016/s0022-2836(02)01152-x

PubMed ID: 12480931

Title: A novel S100 target conformation is revealed by the solution structure of the Ca2+-S100B-TRTK-12 complex.

PubMed ID: 12480931

DOI: 10.1074/jbc.m210622200

Sequence Information:

  • Length: 286
  • Mass: 32923
  • Checksum: 0F47ADAB6A3689DD
  • Sequence:
    • MADFDDRVSD EEKVRIAAKF ITHAPPGEFN EVFNDVRLLL NNDNLLREGA AHAFAQYNMD 
QFTPVKIEGY EDQVLITEHG DLGNSRFLDP RNKISFKFDH LRKEASDPQP EEADGGLKSW 
RESCDSALRA YVKDHYSNGF CTVYAKTIDG QQTIIACIES HQFQPKNFWN GRWRSEWKFT 
ITPPTAQVVG VLKIQVHYYE DGNVQLVSHK DVQDSLTVSN EAQTAKEFIK IIENAENEYQ 
TAISENYQTM SDTTFKALRR QLPVTRTKID WNKILSYKIG KEMQNA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.