CAPZA1 | ENSG00000116489 | NCBI 829

Details for: CAPZA1

Gene ID: 829

Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: CAPZA1

Ensembl ID: ENSG00000116489

Description: capping actin protein of muscle Z-line subunit alpha 1

Cell Significance Landscape

Display Count:

Associated with

Adaptive immune system
(R-HSA-1280218)
Advanced glycosylation endproduct receptor signaling
(R-HSA-879415)
Asparagine n-linked glycosylation
(R-HSA-446203)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Copi-independent golgi-to-er retrograde traffic
(R-HSA-6811436)
Copi-mediated anterograde transport
(R-HSA-6807878)
Cytokine signaling in immune system
(R-HSA-1280215)
Er to golgi anterograde transport
(R-HSA-199977)
Factors involved in megakaryocyte development and platelet production
(R-HSA-983231)
Gene and protein expression by jak-stat signaling after interleukin-12 stimulation
(R-HSA-8950505)
Golgi-to-er retrograde transport
(R-HSA-8856688)
Hemostasis
(R-HSA-109582)
Hsp90 chaperone cycle for steroid hormone receptors (shr) in the presence of ligand
(R-HSA-3371497)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Interleukin-12 family signaling
(R-HSA-447115)
Interleukin-12 signaling
(R-HSA-9020591)
Intra-golgi and retrograde golgi-to-er traffic
(R-HSA-6811442)
Membrane trafficking
(R-HSA-199991)
Metabolism of proteins
(R-HSA-392499)
Mhc class ii antigen presentation
(R-HSA-2132295)
Post-translational protein modification
(R-HSA-597592)
Sensory perception
(R-HSA-9709957)
Sensory processing of sound
(R-HSA-9659379)
Sensory processing of sound by inner hair cells of the cochlea
(R-HSA-9662360)
Signaling by interleukins
(R-HSA-449147)
Transport to the golgi and subsequent modification
(R-HSA-948021)
Vesicle-mediated transport
(R-HSA-5653656)
Actin binding
(GO:0003779)
Actin cytoskeleton
(GO:0015629)
Actin cytoskeleton organization
(GO:0030036)
Actin filament binding
(GO:0051015)
Barbed-end actin filament capping
(GO:0051016)
Cadherin binding
(GO:0045296)
Cell junction assembly
(GO:0034329)
Cortical cytoskeleton
(GO:0030863)
Cytoskeleton
(GO:0005856)
Cytosol
(GO:0005829)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
F-actin capping protein complex
(GO:0008290)
Protein-containing complex assembly
(GO:0065003)
Protein binding
(GO:0005515)
Wash complex
(GO:0071203)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

CD14-low, CD16-positive monocyte CL0002396

CSI 81.12

rCSI 62.5%

PRS 11.72
myeloid leukocyte CL0000766

CSI 53.55

rCSI 49.41%

PRS 13.12
extravillous trophoblast CL0008036

CSI 48.19

rCSI 59.62%

PRS 11.36
Hofbauer cell CL3000001

CSI 42.87

rCSI 80.94%

PRS 16.05
common dendritic progenitor CL0001029

CSI 40.63

rCSI 50.99%

PRS 16.47
intermediate monocyte CL0002393

CSI 31.57

rCSI 47.64%

PRS 12.76
elicited macrophage CL0000861

CSI 30.54

rCSI 28.04%

PRS 14.81
promonocyte CL0000559

CSI 28.66

rCSI 49.11%

PRS 17.31
BEST4+ enteroycte CL4030026

CSI 24.18

rCSI 30.08%

PRS 13.69
myeloid dendritic cell CL0000782

CSI 22.21

rCSI 32.17%

PRS 19.04
granulocyte monocyte progenitor cell CL0000557

CSI 21.91

rCSI 18.97%

PRS 14.42
placental villous trophoblast CL2000060

CSI 16.71

rCSI 25.81%

PRS 12.12
endothelial cell of placenta CL0009092

CSI 15.72

rCSI 77.49%

PRS 17.58
promyelocyte CL0000836

CSI 15.71

rCSI 22.65%

PRS 18
colon macrophage CL0009038

CSI 14.47

rCSI 66.83%

PRS 26.7
memory T cell CL0000813

CSI 13.45

rCSI 25.91%

PRS 28.87
pancreatic acinar cell CL0002064

CSI 12.7

rCSI 16.87%

PRS 14.15
intestinal epithelial cell CL0002563

CSI 12.05

rCSI 12.59%

PRS 13.61
CD14-positive, CD16-negative classical monocyte CL0002057

CSI 12.02

rCSI 72.75%

PRS 28.71
common myeloid progenitor CL0000049

CSI 11.98

rCSI 9.69%

PRS 12.77
large pre-B-II cell CL0000957

CSI 11.55

rCSI 32.98%

PRS 22.29
fraction A pre-pro B cell CL0002045

CSI 10.98

rCSI 12.57%

PRS 26.52
germinal center B cell CL0000844

CSI 10.58

rCSI 31.54%

PRS 31.91
myeloid lineage restricted progenitor cell CL0000839

CSI 10.45

rCSI 53.98%

PRS 25.4
plasmablast CL0000980

CSI 10.17

rCSI 8%

PRS 15.36
transitional stage B cell CL0000818

CSI 9.19

rCSI 30.1%

PRS 36.01
type B pancreatic cell CL0000169

CSI 7.88

rCSI 17.45%

PRS 12.04
megakaryocyte-erythroid progenitor cell CL0000050

CSI 7.69

rCSI 6.95%

PRS 11.44
fallopian tube secretory epithelial cell CL4030006

CSI 7.5

rCSI 7.22%

PRS 13.4
stem cell CL0000034

CSI 7.07

rCSI 6.81%

PRS 8.94
mature alpha-beta T cell CL0000791

CSI 7.05

rCSI 25.51%

PRS 22.19
conventional dendritic cell CL0000990

CSI 6.73

rCSI 5.61%

PRS 37.34
double-positive, alpha-beta thymocyte CL0000809

CSI 6.69

rCSI 6.82%

PRS 18.49
alveolar macrophage CL0000583

CSI 6.46

rCSI 10.65%

PRS 15.06
hematopoietic stem cell CL0000037

CSI 6.44

rCSI 4.28%

PRS 15.41
lymphoid lineage restricted progenitor cell CL0000838

CSI 5.96

rCSI 23.2%

PRS 21.19
helper T cell CL0000912

CSI 5.86

rCSI 8.29%

PRS 18.08
myeloid dendritic cell, human CL0001057

CSI 5.46

rCSI 30.73%

PRS 40.41
enterocyte of epithelium of large intestine CL0002071

CSI 5.3

rCSI 27.84%

PRS 22.92
transit amplifying cell of small intestine CL0009012

CSI 4.96

rCSI 21.77%

PRS 24.11
eosinophil CL0000771

CSI 4.78

rCSI 31.35%

PRS 33.35
foveolar cell of stomach CL0002179

CSI 4.57

rCSI 9.74%

PRS 20.85
paneth cell CL0000510

CSI 4.44

rCSI 6.55%

PRS 20.38
CD14-positive, CD16-positive monocyte CL0002397

CSI 4.44

rCSI 5.81%

PRS 18.11
effector memory CD4-positive, alpha-beta T cell CL0000905

CSI 4.41

rCSI 6.01%

PRS 30.99
macrophage CL0000235

CSI 4.28

rCSI 7.78%

PRS 49.03
pancreatic stellate cell CL0002410

CSI 4.21

rCSI 24.48%

PRS 19.45
colon epithelial cell CL0011108

CSI 3.95

rCSI 4.14%

PRS 12.06
L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI 3.93

rCSI 14.13%

PRS 7.06
CD4-positive helper T cell CL0000492

CSI 3.81

rCSI 2.88%

PRS 17.87
intestinal crypt stem cell of colon CL0009043

CSI 3.66

rCSI 27.45%

PRS 23.68
mature T cell CL0002419

CSI 3.55

rCSI 2.76%

PRS 18.61
goblet cell CL0000160

CSI 3.34

rCSI 3.15%

PRS 13.53
inflammatory macrophage CL0000863

CSI 3.15

rCSI 5.38%

PRS 25.95
dendritic cell CL0000451

CSI 3.02

rCSI 3.72%

PRS 40.43
colon goblet cell CL0009039

CSI 2.98

rCSI 7.07%

PRS 19.48
blood vessel smooth muscle cell CL0019018

CSI 2.94

rCSI 23.94%

PRS 13.36
non-classical monocyte CL0000875

CSI 2.91

rCSI 4.66%

PRS 39.08
enterocyte CL0000584

CSI 2.82

rCSI 4.55%

PRS 20.69
tuft cell of colon CL0009041

CSI 2.8

rCSI 6.52%

PRS 27.28
monocyte CL0000576

CSI 2.79

rCSI 5.04%

PRS 34.43
CD1c-positive myeloid dendritic cell CL0002399

CSI 2.78

rCSI 3.35%

PRS 15.21
tissue-resident macrophage CL0000864

CSI 2.71

rCSI 12.7%

PRS 26.58
myeloid cell CL0000763

CSI 2.71

rCSI 11.15%

PRS 40.88
intestinal crypt stem cell of small intestine CL0009017

CSI 2.7

rCSI 7.28%

PRS 16.66
activated CD4-positive, alpha-beta T cell CL0000896

CSI 2.66

rCSI 2.46%

PRS 23.5
secretory cell CL0000151

CSI 2.63

rCSI 2.74%

PRS 13.25
cerebral cortex GABAergic interneuron CL0010011

CSI 2.52

rCSI 7.44%

PRS 15.8
precursor B cell CL0000817

CSI 2.48

rCSI 2.17%

PRS 17.14
activated type II NK T cell CL0000931

CSI 2.38

rCSI 2.68%

PRS 20.73
M cell of gut CL0000682

CSI 2.34

rCSI 2.49%

PRS 22.92
epithelial cell of lung CL0000082

CSI 2.29

rCSI 1.9%

PRS 12.2
memory B cell CL0000787

CSI 2.28

rCSI 2.25%

PRS 48.01
mucosal invariant T cell CL0000940

CSI 2.21

rCSI 1.79%

PRS 21.22
mature NK T cell CL0000814

CSI 2.2

rCSI 2.81%

PRS 50.39
epithelial cell of esophagus CL0002252

CSI 2.14

rCSI 21.11%

PRS 44.79
direct pathway medium spiny neuron CL4023026

CSI 2.1

rCSI 50.22%

PRS 5.84
B-1 B cell CL0000819

CSI 2.09

rCSI 53.82%

PRS 57.82
early lymphoid progenitor CL0000936

CSI 2.05

rCSI 1.8%

PRS 14.52
naive B cell CL0000788

CSI 1.99

rCSI 1.71%

PRS 22.68
hepatocyte CL0000182

CSI 1.97

rCSI 3.52%

PRS 12.06
pro-B cell CL0000826

CSI 1.95

rCSI 1.62%

PRS 12.93
indirect pathway medium spiny neuron CL4023029

CSI 1.95

rCSI 47%

PRS 6.72
plasmacytoid dendritic cell CL0000784

CSI 1.91

rCSI 1.94%

PRS 61.56
perivascular cell CL4033054

CSI 1.88

rCSI 2.57%

PRS 14.69
CD8-positive, alpha-beta memory T cell CL0000909

CSI 1.87

rCSI 1.96%

PRS 38.31
Mueller cell CL0000636

CSI 1.86

rCSI 4.25%

PRS 11.35
peripheral nervous system neuron CL2000032

CSI 1.85

rCSI 2.52%

PRS 11.54
chondrocyte CL0000138

CSI 1.83

rCSI 2.91%

PRS 11.08
bronchus fibroblast of lung CL2000093

CSI 1.81

rCSI 1.47%

PRS 13.67
granulocyte CL0000094

CSI 1.8

rCSI 2.75%

PRS 16.34
hepatic stellate cell CL0000632

CSI 1.8

rCSI 6.74%

PRS 10.96
melanocyte CL0000148

CSI 1.8

rCSI 1.33%

PRS 11.44
bronchial goblet cell CL1000312

CSI 1.78

rCSI 7.12%

PRS 28.28
CD4-positive, alpha-beta cytotoxic T cell CL0000934

CSI 1.78

rCSI 2.44%

PRS 26.65
pancreatic D cell CL0000173

CSI 1.76

rCSI 1.74%

PRS 14.07
basophil CL0000767

CSI 1.75

rCSI 3.71%

PRS 26.19
myofibroblast cell CL0000186

CSI 1.75

rCSI 2.42%

PRS 18.58
conjunctival epithelial cell CL1000432

CSI 1.74

rCSI 2.66%

PRS 12.94
double negative thymocyte CL0002489

CSI 1.74

rCSI 1.21%

PRS 15.15

parietal epithelial cell CL1000452

CSI -6.1

rCSI -16.2%

PRS 11.0%
renal beta-intercalated cell CL0002201

CSI -5.5

rCSI -13.1%

PRS 15.5%
CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792

CSI -1.9

rCSI -1.9%

PRS 20.3%
adventitial cell CL0002503

CSI -1.1

rCSI -2.7%

PRS 20.1%
tracheobronchial smooth muscle cell CL0019019

CSI -1.1

rCSI -1.9%

PRS 17.1%
nasal mucosa goblet cell CL0002480

CSI -1.1

rCSI -1.2%

PRS 19.1%
group 3 innate lymphoid cell CL0001071

CSI -1.0

rCSI -0.7%

PRS 13.4%
cardiac neuron CL0010022

CSI -0.9

rCSI -3.0%

PRS 9.2%
dopaminergic neuron CL0000700

CSI -0.9

rCSI -5.1%

PRS 5.3%
periportal region hepatocyte CL0019026

CSI -0.5

rCSI -2.1%

PRS 18.1%
lung pericyte CL0009089

CSI -0.5

rCSI -1.3%

PRS 15.4%
ON-bipolar cell CL0000749

CSI -0.5

rCSI -0.7%

PRS 15.8%
platelet CL0000233

CSI -0.2

rCSI -0.9%

PRS 27.0%
retinal cone cell CL0000573

CSI -0.1

rCSI -0.2%

PRS 10.0%
kidney connecting tubule epithelial cell CL1000768

CSI -0.1

rCSI -0.1%

PRS 9.9%
respiratory goblet cell CL0002370

CSI 0.0

rCSI 0.4%

PRS 24.9%
regular ventricular cardiac myocyte CL0002131

CSI 0.1

rCSI 0.4%

PRS 10.1%
B-2 B cell CL0000822

CSI 0.1

rCSI 1.2%

PRS 61.5%
cytotoxic T cell CL0000910

CSI 0.1

rCSI 0.4%

PRS 18.9%
basal-myoepithelial cell of mammary gland CL0002324

CSI 0.1

rCSI 0.1%

PRS 28.1%
amacrine cell CL0000561

CSI 0.1

rCSI 0.2%

PRS 10.1%
group 2 innate lymphoid cell CL0001069

CSI 0.1

rCSI 0.5%

PRS 43.0%
retina horizontal cell CL0000745

CSI 0.1

rCSI 0.2%

PRS 12.1%
cerebral cortex neuron CL0010012

CSI 0.1

rCSI 0.5%

PRS 13.4%
duct epithelial cell CL0000068

CSI 0.1

rCSI 0.2%

PRS 13.7%
metallothionein-positive alveolar macrophage CL4033042

CSI 0.2

rCSI 1.7%

PRS 48.7%
OFF-bipolar cell CL0000750

CSI 0.2

rCSI 0.2%

PRS 21.1%
effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062

CSI 0.2

rCSI 0.8%

PRS 16.9%
decidual natural killer cell, human CL0002343

CSI 0.2

rCSI 1.7%

PRS 68.4%
tracheobronchial serous cell CL0019001

CSI 0.2

rCSI 0.8%

PRS 24.7%
forebrain radial glial cell CL0013000

CSI 0.2

rCSI 0.6%

PRS 18.9%
regular atrial cardiac myocyte CL0002129

CSI 0.2

rCSI 0.6%

PRS 13.8%
CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell CL0000915

CSI 0.2

rCSI 0.9%

PRS 44.5%
epithelial cell of urethra CL1000296

CSI 0.2

rCSI 5.3%

PRS 40.7%
podocyte CL0000653

CSI 0.2

rCSI 1.0%

PRS 12.8%
renal interstitial pericyte CL1001318

CSI 0.2

rCSI 0.6%

PRS 12.1%
ionocyte CL0005006

CSI 0.3

rCSI 0.3%

PRS 11.9%
acinar cell of salivary gland CL0002623

CSI 0.3

rCSI 6.1%

PRS 23.2%
lung ciliated cell CL1000271

CSI 0.3

rCSI 0.3%

PRS 9.5%
centrilobular region hepatocyte CL0019029

CSI 0.3

rCSI 0.7%

PRS 20.6%
endothelial cell of pericentral hepatic sinusoid CL0019022

CSI 0.3

rCSI 0.9%

PRS 20.1%
pancreatic epsilon cell CL0005019

CSI 0.3

rCSI 1.3%

PRS 30.7%
squamous epithelial cell CL0000076

CSI 0.3

rCSI 0.7%

PRS 16.4%
Cajal-Retzius cell CL0000695

CSI 0.3

rCSI 2.3%

PRS 28.0%
pulmonary alveolar type 1 cell CL0002062

CSI 0.3

rCSI 1.8%

PRS 17.2%
professional antigen presenting cell CL0000145

CSI 0.3

rCSI 1.1%

PRS 47.3%
pancreatic PP cell CL0002275

CSI 0.3

rCSI 1.3%

PRS 22.7%
brush cell CL0002204

CSI 0.3

rCSI 0.6%

PRS 33.5%
glandular epithelial cell CL0000150

CSI 0.3

rCSI 0.9%

PRS 25.3%
rod bipolar cell CL0000751

CSI 0.3

rCSI 0.6%

PRS 10.8%
renal alpha-intercalated cell CL0005011

CSI 0.3

rCSI 0.5%

PRS 17.1%
renal intercalated cell CL0005010

CSI 0.3

rCSI 3.1%

PRS 74.4%
pulmonary ionocyte CL0017000

CSI 0.4

rCSI 0.4%

PRS 16.3%
VIP GABAergic cortical interneuron CL4023016

CSI 0.4

rCSI 0.4%

PRS 7.4%
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 0.4

rCSI 0.6%

PRS 7.6%
ciliated cell CL0000064

CSI 0.4

rCSI 0.6%

PRS 13.2%
class switched memory B cell CL0000972

CSI 0.4

rCSI 0.3%

PRS 21.7%
deuterosomal cell CL4033044

CSI 0.4

rCSI 1.3%

PRS 21.8%
luminal epithelial cell of mammary gland CL0002326

CSI 0.4

rCSI 0.7%

PRS 19.8%
primitive red blood cell CL0002355

CSI 0.4

rCSI 2.1%

PRS 24.2%
sncg GABAergic cortical interneuron CL4023015

CSI 0.4

rCSI 0.6%

PRS 8.3%
retinal pigment epithelial cell CL0002586

CSI 0.4

rCSI 0.8%

PRS 13.8%
vein endothelial cell of respiratory system CL4033008

CSI 0.4

rCSI 2.8%

PRS 25.3%
hematopoietic multipotent progenitor cell CL0000837

CSI 0.4

rCSI 1.0%

PRS 20.5%
retinal rod cell CL0000604

CSI 0.4

rCSI 0.7%

PRS 12.8%
central nervous system neuron CL2000029

CSI 0.4

rCSI 3.1%

PRS 6.6%
T-helper 17 cell CL0000899

CSI 0.4

rCSI 0.3%

PRS 22.8%
luminal cell of prostate epithelium CL0002340

CSI 0.4

rCSI 2.3%

PRS 23.3%
antibody secreting cell CL0000946

CSI 0.4

rCSI 1.9%

PRS 50.3%
acinar cell CL0000622

CSI 0.4

rCSI 0.6%

PRS 17.0%
OFF midget ganglion cell CL4033047

CSI 0.4

rCSI 8.8%

PRS 10.9%
kidney interstitial alternatively activated macrophage CL1000695

CSI 0.4

rCSI 1.1%

PRS 11.8%
enteric smooth muscle cell CL0002504

CSI 0.4

rCSI 0.6%

PRS 14.6%
fibroblast of breast CL4006000

CSI 0.4

rCSI 1.8%

PRS 33.0%
thymocyte CL0000893

CSI 0.5

rCSI 1.6%

PRS 40.1%
lamp5 GABAergic cortical interneuron CL4023011

CSI 0.5

rCSI 0.8%

PRS 7.6%
L4 intratelencephalic projecting glutamatergic neuron CL4030063

CSI 0.5

rCSI 1.1%

PRS 7.1%
small pre-B-II cell CL0000954

CSI 0.5

rCSI 0.4%

PRS 26.7%
kidney loop of Henle thin descending limb epithelial cell CL1001111

CSI 0.5

rCSI 0.7%

PRS 12.1%
type L enteroendocrine cell CL0002279

CSI 0.5

rCSI 0.9%

PRS 25.6%
mucous neck cell CL0000651

CSI 0.5

rCSI 0.7%

PRS 20.8%
lung interstitial macrophage CL4033043

CSI 0.5

rCSI 1.1%

PRS 26.6%
enterocyte of epithelium of small intestine CL1000334

CSI 0.5

rCSI 7.5%

PRS 32.0%
choroid plexus epithelial cell CL0000706

CSI 0.5

rCSI 0.8%

PRS 10.0%
glycinergic amacrine cell CL4030028

CSI 0.5

rCSI 1.3%

PRS 12.7%
mesodermal cell CL0000222

CSI 0.5

rCSI 0.6%

PRS 12.8%
stromal cell of ovary CL0002132

CSI 0.5

rCSI 1.4%

PRS 21.3%
near-projecting glutamatergic cortical neuron CL4023012

CSI 0.5

rCSI 1.9%

PRS 7.8%
alveolar type 1 fibroblast cell CL4028004

CSI 0.5

rCSI 0.6%

PRS 14.8%
basophil mast progenitor cell CL0002028

CSI 0.5

rCSI 2.7%

PRS 46.6%
CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203

CSI 0.5

rCSI 0.6%

PRS 17.1%
IgM plasma cell CL0000986

CSI 0.5

rCSI 2.3%

PRS 56.2%
IgG plasma cell CL0000985

CSI 0.5

rCSI 0.6%

PRS 22.2%
type EC enteroendocrine cell CL0000577

CSI 0.5

rCSI 1.9%

PRS 21.2%
lung secretory cell CL1000272

CSI 0.5

rCSI 1.3%

PRS 12.0%
H1 horizontal cell CL0004217

CSI 0.5

rCSI 2.1%

PRS 18.2%
mucus secreting cell CL0000319

CSI 0.5

rCSI 0.9%

PRS 16.7%
epicardial adipocyte CL1000309

CSI 0.5

rCSI 1.8%

PRS 15.7%
ON parasol ganglion cell CL4033052

CSI 0.5

rCSI 7.7%

PRS 9.0%
mature B cell CL0000785

CSI 0.5

rCSI 0.5%

PRS 16.0%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Context Genes (max 20):

Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

Legend:

Query Gene
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
STRING PPI Edge
Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [CAPZA1](/details-gene/829) encodes the alpha-1 subunit of the F-actin-capping protein complex, a heterodimer that binds to the fast-growing barbed ends of actin filaments, thereby regulating actin polymerization and cytoskeleton dynamics. Its function is fundamental to processes requiring cellular motility, structural integrity, and morphological changes. **Overall**, expression data reveals that [CAPZA1](/details-gene/829) is a highly significant gene in cells of the myeloid lineage, particularly [CD14-low, CD16-positive monocyte](/details-cell/CL0002396) and general [myeloid leukocyte](/details-cell/CL0000766) populations. This specific expression pattern, combined with its role in actin organization, suggests a critical function in the immune surveillance, phagocytosis, and migration characteristic of these cells. Additionally, its prominent expression in placental cells like [extravillous trophoblast](/details-cell/CL0008036) points towards an important role in embryonic development and implantation. ## Cellular Roles and Expression Landscape The expression profile of [CAPZA1](/details-gene/829) strongly indicates a specialized role within the hematopoietic system, with a clear bias towards the myeloid compartment. **Overall**, its most significant expression is observed in [CD14-low, CD16-positive monocyte](/details-cell/CL0002396) (CSI: 81.12), followed by a broader signature across [myeloid leukocyte](/details-cell/CL0000766) (CSI: 53.55) populations and their progenitors, including [common dendritic progenitor](/details-cell/CL0001029) and [promonocyte](/details-cell/CL0000559). This pattern extends to terminally differentiated phagocytes such as [Hofbauer cell](/details-cell/CL3000001) (CSI: 42.87) and [elicited macrophage](/details-cell/CL0000861) (CSI: 30.54), underscoring its importance in the functional activities of these key innate immune cells, which rely heavily on dynamic cytoskeletal rearrangement. Beyond the immune system, [CAPZA1](/details-gene/829) also demonstrates high significance in specialized placental cells, namely [extravillous trophoblast](/details-cell/CL0008036) (CSI: 48.19) and [placental villous trophoblast](/details-cell/CL2000060) (CSI: 16.71). This suggests a role in the invasive and structural functions of the placenta during pregnancy. Conversely, the gene's significance is notably low or negative in a wide range of other cell types. Its lack of expression in various neuronal cells (e.g., [cardiac neuron](/details-cell/CL0010022), [dopaminergic neuron](/details-cell/CL0000700)), certain epithelial cells ([parietal epithelial cell](/details-cell/CL1000452)), and lymphoid cells like [CD4-positive, CD25-positive, alpha-beta regulatory T cell](/details-cell/CL0000792) defines its specificity and points to a specialized function outside of these lineages, reinforcing its primary association with myeloid and placental biology. ## Pathways and Molecular Function The molecular functions of [CAPZA1](/details-gene/829) are intrinsically linked to its role as a core component of the cytoskeleton. Gene Ontology annotations confirm its involvement in [Actin cytoskeleton organization (GO:0030036)](https://www.ebi.ac.uk/QuickGO/term/GO:0030036), driven by its specific molecular function of [Barbed-end actin filament capping (GO:0051016)](https://www.ebi.ac.uk/QuickGO/term/GO:0051016) and [Actin binding (GO:0003779)](https://www.ebi.ac.uk/QuickGO/term/GO:0003779). By controlling the growth of actin filaments, it influences cell shape, adhesion, and movement. Its participation in the [F-actin capping protein complex (GO:0008290)](https://www.ebi.ac.uk/QuickGO/term/GO:0008290) is central to this activity. Consistent with its high expression in immune cells, [CAPZA1](/details-gene/829) is annotated in broad immune-related Reactome pathways, including the [Immune system (R-HSA-168256)](https://reactome.org/content/detail/R-HSA-168256), [Innate immune system (R-HSA-168249)](https://reactome.org/content/detail/R-HSA-168249), and [Cytokine signaling in immune system (R-HSA-1280215)](https://reactome.org/content/detail/R-HSA-1280215). These connections are likely indirect, reflecting the necessity of a dynamic cytoskeleton for immune cells to execute their functions, such as migration, antigen presentation ([Mhc class ii antigen presentation (R-HSA-2132295)](https://reactome.org/content/detail/R-HSA-2132295)), and responding to stimuli ([Cellular responses to stimuli (R-HSA-8953897)](https://reactome.org/content/detail/R-HSA-8953897)). Its association with [Hemostasis (R-HSA-109582)](https://reactome.org/content/detail/R-HSA-109582) may relate to the role of myeloid cells and platelets in clotting and wound healing processes, which also depend on cytoskeletal control. ## Research Directions The specific and high expression of [CAPZA1](/details-gene/829) in myeloid and placental cells, coupled with its fundamental role in actin dynamics, suggests several avenues for future research into its role in health and disease. ### Proposed Hypotheses: 1. **Impaired macrophage function in inflammatory disease:** Given its high significance in monocytes and macrophages, it is hypothesized that altered expression or function of [CAPZA1](/details-gene/829) contributes to defective macrophage migration and phagocytosis in chronic inflammatory conditions or during tumor infiltration, thereby modulating the tissue microenvironment. 2. **Role in placental development and pathology:** The prominent expression in [extravillous trophoblast](/details-cell/CL0008036) suggests a critical role in trophoblast invasion of the uterine wall. It is hypothesized that insufficient [CAPZA1](/details-gene/829) function could lead to shallow placental implantation, a key pathological feature of pre-eclampsia. 3. **Regulation of dendritic cell maturation:** As [CAPZA1](/details-gene/829) is highly expressed in [common dendritic progenitor](/details-cell/CL0001029) and [myeloid dendritic cell](/details-cell/CL0000782), it is hypothesized that it regulates the dramatic morphological changes that dendritic cells undergo during maturation and antigen presentation, and its dysregulation could impair the initiation of adaptive immune responses. ### Key Experimental Approach: To test the hypothesis regarding macrophage function (Hypothesis 1), a targeted genetic approach could be employed. Specifically, CRISPR-Cas9 could be used to knock out [CAPZA1](/details-gene/829) in a human monocytic cell line (e.g., THP-1) or in primary human monocytes. Following differentiation into macrophages, these [CAPZA1](/details-gene/829)-deficient cells and their wild-type counterparts could be assessed in parallel. Key functional assays would include: (i) a phagocytosis assay using fluorescently labeled zymosan particles or E. coli, quantified by flow cytometry or microscopy, and (ii) a transwell migration assay to measure chemotaxis in response to a chemoattractant like C5a or CCL2. A significant reduction in phagocytic capacity or migratory ability in knockout cells would provide direct evidence for its essential role in macrophage function. ### Therapeutic Potential: As an intracellular structural protein essential for a ubiquitous cellular process, [CAPZA1](/details-gene/829) is unlikely to be a viable direct therapeutic target for inhibition or activation, as this would likely cause significant toxicity. However, its high and specific expression in myeloid cells suggests it could serve as a valuable biomarker. For example, quantifying [CAPZA1](/details-gene/829) expression levels in tumor-associated macrophages (TAMs) could potentially correlate with their migratory or invasive phenotype, offering prognostic value in cancer. Furthermore, understanding the pathways that regulate [CAPZA1](/details-gene/829) in these cells may reveal more druggable upstream targets for modulating myeloid cell function in disease.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

F-actin-capping protein subunit alpha-1

Genular Protein ID: 1572380775

Symbol: CAZA1_HUMAN

Name: F-actin-capping protein subunit alpha-1

UniProtKB Accession Codes:

P52907 Q53FQ6 Q6FHD5

Database IDs:

Citations:

PubMed ID: 9331217

Title: Vertebrates have conserved capping protein alpha isoforms with specific expression patterns.

PubMed ID: 9331217

DOI: 10.1002/(sici)1097-0169(1997)38:2<120::aid-cm2>3.0.co;2-b

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19922875

Title: The Arp2/3 activator WASH controls the fission of endosomes through a large multiprotein complex.

PubMed ID: 19922875

DOI: 10.1016/j.devcel.2009.09.010

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22891260

Title: Epithelial junction formation requires confinement of Cdc42 activity by a novel SH3BP1 complex.

PubMed ID: 22891260

DOI: 10.1083/jcb.201202094

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 30361697

Title: Deregulation of CRAD-controlled cytoskeleton initiates mucinous colorectal cancer via beta-catenin.

PubMed ID: 30361697

DOI: 10.1038/s41556-018-0215-z

PubMed ID: 24951542

Title: A missense mutation in the PISA domain of HsSAS-6 causes autosomal recessive primary microcephaly in a large consanguineous Pakistani family.

PubMed ID: 24951542

DOI: 10.1093/hmg/ddu318

PubMed ID: 12470955

Title: Solution NMR structure of S100B bound to the high-affinity target peptide TRTK-12.

PubMed ID: 12470955

DOI: 10.1016/s0022-2836(02)01152-x

PubMed ID: 12480931

Title: A novel S100 target conformation is revealed by the solution structure of the Ca2+-S100B-TRTK-12 complex.

PubMed ID: 12480931

DOI: 10.1074/jbc.m210622200

Sequence Information:

Length: 286
Mass: 32923
Checksum: 0F47ADAB6A3689DD
Sequence:

MADFDDRVSD EEKVRIAAKF ITHAPPGEFN EVFNDVRLLL NNDNLLREGA AHAFAQYNMD 
QFTPVKIEGY EDQVLITEHG DLGNSRFLDP RNKISFKFDH LRKEASDPQP EEADGGLKSW 
RESCDSALRA YVKDHYSNGF CTVYAKTIDG QQTIIACIES HQFQPKNFWN GRWRSEWKFT 
ITPPTAQVVG VLKIQVHYYE DGNVQLVSHK DVQDSLTVSN EAQTAKEFIK IIENAENEYQ 
TAISENYQTM SDTTFKALRR QLPVTRTKID WNKILSYKIG KEMQNA

Details for: CAPZA1

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

Vertebrates have conserved capping protein alpha isoforms with specific expression patterns. PubMed ID: 9331217

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

The Arp2/3 activator WASH controls the fission of endosomes through a large multiprotein complex. PubMed ID: 19922875

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Initial characterization of the human central proteome. PubMed ID: 21269460

Epithelial junction formation requires confinement of Cdc42 activity by a novel SH3BP1 complex. PubMed ID: 22891260

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Deregulation of CRAD-controlled cytoskeleton initiates mucinous colorectal cancer via beta-catenin. PubMed ID: 30361697

A missense mutation in the PISA domain of HsSAS-6 causes autosomal recessive primary microcephaly in a large consanguineous Pakistani family. PubMed ID: 24951542

Solution NMR structure of S100B bound to the high-affinity target peptide TRTK-12. PubMed ID: 12470955

A novel S100 target conformation is revealed by the solution structure of the Ca2+-S100B-TRTK-12 complex. PubMed ID: 12480931