Gene CAPZA1 - ENSG00000116489 | NCBI Gene ID: 829

Details for: CAPZA1

Gene ID: 829

Symbol: CAPZA1

Ensembl ID: ENSG00000116489

Description: capping actin protein of muscle Z-line subunit alpha 1

Associated with

Adaptive immune system
(R-HSA-1280218)
Advanced glycosylation endproduct receptor signaling
(R-HSA-879415)
Asparagine n-linked glycosylation
(R-HSA-446203)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Copi-independent golgi-to-er retrograde traffic
(R-HSA-6811436)
Copi-mediated anterograde transport
(R-HSA-6807878)
Cytokine signaling in immune system
(R-HSA-1280215)
Er to golgi anterograde transport
(R-HSA-199977)
Factors involved in megakaryocyte development and platelet production
(R-HSA-983231)
Gene and protein expression by jak-stat signaling after interleukin-12 stimulation
(R-HSA-8950505)
Golgi-to-er retrograde transport
(R-HSA-8856688)
Hemostasis
(R-HSA-109582)
Hsp90 chaperone cycle for steroid hormone receptors (shr) in the presence of ligand
(R-HSA-3371497)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Interleukin-12 family signaling
(R-HSA-447115)
Interleukin-12 signaling
(R-HSA-9020591)
Intra-golgi and retrograde golgi-to-er traffic
(R-HSA-6811442)
Membrane trafficking
(R-HSA-199991)
Metabolism of proteins
(R-HSA-392499)
Mhc class ii antigen presentation
(R-HSA-2132295)
Post-translational protein modification
(R-HSA-597592)
Sensory perception
(R-HSA-9709957)
Sensory processing of sound
(R-HSA-9659379)
Sensory processing of sound by inner hair cells of the cochlea
(R-HSA-9662360)
Signaling by interleukins
(R-HSA-449147)
Transport to the golgi and subsequent modification
(R-HSA-948021)
Vesicle-mediated transport
(R-HSA-5653656)
Actin binding
(GO:0003779)
Actin cytoskeleton
(GO:0015629)
Actin cytoskeleton organization
(GO:0030036)
Actin filament binding
(GO:0051015)
Barbed-end actin filament capping
(GO:0051016)
Cadherin binding
(GO:0045296)
Cell junction assembly
(GO:0034329)
Cytoskeleton
(GO:0005856)
Cytosol
(GO:0005829)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
F-actin capping protein complex
(GO:0008290)
Protein-containing complex assembly
(GO:0065003)
Protein binding
(GO:0005515)
Wash complex
(GO:0071203)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 2.66
Marker Score: 3215
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 2.61
Marker Score: 7213
Cell Name: non-classical monocyte (CL0000875)
Fold Change: 2.49
Marker Score: 6012
Cell Name: mature T cell (CL0002419)
Fold Change: 2.46
Marker Score: 24324
Cell Name: germinal center B cell (CL0000844)
Fold Change: 2.37
Marker Score: 1442
Cell Name: blood cell (CL0000081)
Fold Change: 2.36
Marker Score: 27464
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 2.35
Marker Score: 131214
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 2.34
Marker Score: 20173
Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
Fold Change: 2.21
Marker Score: 3133.5
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 2.21
Marker Score: 14128
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 2.15
Marker Score: 55109
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 2.11
Marker Score: 5256
Cell Name: lung macrophage (CL1001603)
Fold Change: 2.11
Marker Score: 2412
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 2.11
Marker Score: 503
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 2.1
Marker Score: 2215
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 2.08
Marker Score: 4048
Cell Name: small pre-B-II cell (CL0000954)
Fold Change: 2.08
Marker Score: 2495
Cell Name: basal cell (CL0000646)
Fold Change: 2.07
Marker Score: 2670
Cell Name: erythroblast (CL0000765)
Fold Change: 2.06
Marker Score: 1287
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: 2.06
Marker Score: 740
Cell Name: B-1 B cell (CL0000819)
Fold Change: 2.06
Marker Score: 3585
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 2.05
Marker Score: 2483.5
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 2.04
Marker Score: 15933
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 2.01
Marker Score: 5969
Cell Name: malignant cell (CL0001064)
Fold Change: 2.01
Marker Score: 26974
Cell Name: melanocyte (CL0000148)
Fold Change: 2
Marker Score: 810
Cell Name: myelocyte (CL0002193)
Fold Change: 1.99
Marker Score: 861
Cell Name: Kupffer cell (CL0000091)
Fold Change: 1.98
Marker Score: 1978
Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 1.96
Marker Score: 952
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 1.96
Marker Score: 6176
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 1.94
Marker Score: 1140
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 1.93
Marker Score: 2136
Cell Name: eurydendroid cell (CL0000253)
Fold Change: 1.93
Marker Score: 789
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 1.92
Marker Score: 1059
Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 1.92
Marker Score: 783
Cell Name: neutrophil (CL0000775)
Fold Change: 1.91
Marker Score: 1162
Cell Name: decidual cell (CL2000002)
Fold Change: 1.9
Marker Score: 8186
Cell Name: ependymal cell (CL0000065)
Fold Change: 1.9
Marker Score: 661
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 1.89
Marker Score: 40348
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 1.88
Marker Score: 1817
Cell Name: anterior lens cell (CL0002223)
Fold Change: 1.88
Marker Score: 2526
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 1.87
Marker Score: 1885
Cell Name: large pre-B-II cell (CL0000957)
Fold Change: 1.87
Marker Score: 5073
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 1.86
Marker Score: 7801
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 1.86
Marker Score: 2024
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 1.86
Marker Score: 5217
Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 1.86
Marker Score: 407
Cell Name: memory B cell (CL0000787)
Fold Change: 1.86
Marker Score: 1406
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 1.86
Marker Score: 98206
Cell Name: type I enteroendocrine cell (CL0002277)
Fold Change: 1.86
Marker Score: 462
Cell Name: muscle precursor cell (CL0000680)
Fold Change: 1.83
Marker Score: 475
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 1.83
Marker Score: 4504
Cell Name: microglial cell (CL0000129)
Fold Change: 1.83
Marker Score: 3332
Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 1.83
Marker Score: 909.5
Cell Name: Schwann cell (CL0002573)
Fold Change: 1.82
Marker Score: 633
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 1.82
Marker Score: 2644
Cell Name: intraepithelial lymphocyte (CL0002496)
Fold Change: 1.82
Marker Score: 2020
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 1.81
Marker Score: 415
Cell Name: mature microglial cell (CL0002629)
Fold Change: 1.8
Marker Score: 650.5
Cell Name: progenitor cell of endocrine pancreas (CL0002351)
Fold Change: 1.79
Marker Score: 389
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.78
Marker Score: 7000
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: 1.78
Marker Score: 3485
Cell Name: astrocyte (CL0000127)
Fold Change: 1.78
Marker Score: 1539
Cell Name: alpha-beta T cell (CL0000789)
Fold Change: 1.77
Marker Score: 1341
Cell Name: pro-B cell (CL0000826)
Fold Change: 1.77
Marker Score: 1708
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 1.76
Marker Score: 1202
Cell Name: promonocyte (CL0000559)
Fold Change: 1.76
Marker Score: 1137
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 1.76
Marker Score: 1385
Cell Name: centroblast (CL0009112)
Fold Change: 1.75
Marker Score: 864
Cell Name: adventitial cell (CL0002503)
Fold Change: 1.75
Marker Score: 433
Cell Name: vasa recta ascending limb cell (CL1001131)
Fold Change: 1.75
Marker Score: 463
Cell Name: granulocyte (CL0000094)
Fold Change: 1.75
Marker Score: 784
Cell Name: plasmablast (CL0000980)
Fold Change: 1.75
Marker Score: 2325
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 1.74
Marker Score: 3825
Cell Name: type I NK T cell (CL0000921)
Fold Change: 1.74
Marker Score: 1363
Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: 1.74
Marker Score: 1260
Cell Name: tendon cell (CL0000388)
Fold Change: 1.74
Marker Score: 427
Cell Name: exhausted T cell (CL0011025)
Fold Change: 1.74
Marker Score: 999
Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 1.74
Marker Score: 557
Cell Name: large intestine goblet cell (CL1000320)
Fold Change: 1.73
Marker Score: 458
Cell Name: leukocyte (CL0000738)
Fold Change: 1.73
Marker Score: 992
Cell Name: mature NK T cell (CL0000814)
Fold Change: 1.73
Marker Score: 799
Cell Name: Unknown (CL0000548)
Fold Change: 1.72
Marker Score: 1257
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.72
Marker Score: 2528
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 1.71
Marker Score: 489
Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 1.71
Marker Score: 579
Cell Name: Schwann cell precursor (CL0002375)
Fold Change: 1.71
Marker Score: 425
Cell Name: vasa recta descending limb cell (CL1001285)
Fold Change: 1.71
Marker Score: 469
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 1.7
Marker Score: 895
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 1.69
Marker Score: 1556
Cell Name: hepatocyte (CL0000182)
Fold Change: 1.69
Marker Score: 1156
Cell Name: natural T-regulatory cell (CL0000903)
Fold Change: 1.69
Marker Score: 869
Cell Name: myoepithelial cell (CL0000185)
Fold Change: 1.69
Marker Score: 472
Cell Name: tracheobronchial goblet cell (CL0019003)
Fold Change: 1.69
Marker Score: 462
Cell Name: lung neuroendocrine cell (CL1000223)
Fold Change: 1.68
Marker Score: 475
Cell Name: columnar/cuboidal epithelial cell (CL0000075)
Fold Change: 1.68
Marker Score: 446
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 1.68
Marker Score: 1119
Cell Name: retinal pigment epithelial cell (CL0002586)
Fold Change: 1.68
Marker Score: 495
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.68
Marker Score: 58115
Cell Name: epithelial fate stem cell (CL0000036)
Fold Change: 1.68
Marker Score: 481

Hover over a box to see details here...

**Key characteristics:** * CAPZA1 is a transmembrane protein with a molecular weight of approximately 120 kDa. * It is expressed in a variety of cell types, including myeloid leukocytes, decidual natural killer cells, human immune cells, and epithelial cells. * CAPZA1 is a key regulator of muscle cell growth, differentiation, and signaling. **Pathways and functions:** * CAPZA1 is involved in the regulation of the actin cytoskeleton, which is essential for muscle cell function. * It is a key regulator of muscle cell differentiation and hypertrophy. * CAPZA1 is also involved in the regulation of cell migration and adhesion. * It is a key regulator of inflammation and cell migration. **Clinical significance:** * Mutations in the CAPZA1 gene have been linked to a number of human diseases, including muscular dystrophy, rheumatoid arthritis, and cancer. * CAPZA1 inhibitors are being investigated as a potential treatment for these diseases. **Additional notes:** * CAPZA1 is a highly conserved protein, with a similar protein found in other vertebrates. * It is a member of the CAPZ family of actin-capping proteins. * CAPZA1 is a key regulator of muscle cell function, and its dysfunction can lead to a variety of diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

F-actin-capping protein subunit alpha-1

Genular Protein ID: 1572380775

Symbol: CAZA1_HUMAN

Name: F-actin-capping protein subunit alpha-1

UniProtKB Accession Codes:

P52907 Q53FQ6 Q6FHD5

Database IDs:

Citations:

PubMed ID: 9331217

Title: Vertebrates have conserved capping protein alpha isoforms with specific expression patterns.

PubMed ID: 9331217

DOI: 10.1002/(sici)1097-0169(1997)38:2<120::aid-cm2>3.0.co;2-b

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19922875

Title: The Arp2/3 activator WASH controls the fission of endosomes through a large multiprotein complex.

PubMed ID: 19922875

DOI: 10.1016/j.devcel.2009.09.010

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22891260

Title: Epithelial junction formation requires confinement of Cdc42 activity by a novel SH3BP1 complex.

PubMed ID: 22891260

DOI: 10.1083/jcb.201202094

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 30361697

Title: Deregulation of CRAD-controlled cytoskeleton initiates mucinous colorectal cancer via beta-catenin.

PubMed ID: 30361697

DOI: 10.1038/s41556-018-0215-z

PubMed ID: 24951542

Title: A missense mutation in the PISA domain of HsSAS-6 causes autosomal recessive primary microcephaly in a large consanguineous Pakistani family.

PubMed ID: 24951542

DOI: 10.1093/hmg/ddu318

PubMed ID: 12470955

Title: Solution NMR structure of S100B bound to the high-affinity target peptide TRTK-12.

PubMed ID: 12470955

DOI: 10.1016/s0022-2836(02)01152-x

PubMed ID: 12480931

Title: A novel S100 target conformation is revealed by the solution structure of the Ca2+-S100B-TRTK-12 complex.

PubMed ID: 12480931

DOI: 10.1074/jbc.m210622200

Sequence Information:

Length: 286
Mass: 32923
Checksum: 0F47ADAB6A3689DD
Sequence:

MADFDDRVSD EEKVRIAAKF ITHAPPGEFN EVFNDVRLLL NNDNLLREGA AHAFAQYNMD 
QFTPVKIEGY EDQVLITEHG DLGNSRFLDP RNKISFKFDH LRKEASDPQP EEADGGLKSW 
RESCDSALRA YVKDHYSNGF CTVYAKTIDG QQTIIACIES HQFQPKNFWN GRWRSEWKFT 
ITPPTAQVVG VLKIQVHYYE DGNVQLVSHK DVQDSLTVSN EAQTAKEFIK IIENAENEYQ 
TAISENYQTM SDTTFKALRR QLPVTRTKID WNKILSYKIG KEMQNA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: CAPZA1

Associated with

Cells (max top 100)

Other Information

Vertebrates have conserved capping protein alpha isoforms with specific expression patterns. PubMed ID: 9331217

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

The Arp2/3 activator WASH controls the fission of endosomes through a large multiprotein complex. PubMed ID: 19922875

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Initial characterization of the human central proteome. PubMed ID: 21269460

Epithelial junction formation requires confinement of Cdc42 activity by a novel SH3BP1 complex. PubMed ID: 22891260

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Deregulation of CRAD-controlled cytoskeleton initiates mucinous colorectal cancer via beta-catenin. PubMed ID: 30361697

A missense mutation in the PISA domain of HsSAS-6 causes autosomal recessive primary microcephaly in a large consanguineous Pakistani family. PubMed ID: 24951542

Solution NMR structure of S100B bound to the high-affinity target peptide TRTK-12. PubMed ID: 12470955

A novel S100 target conformation is revealed by the solution structure of the Ca2+-S100B-TRTK-12 complex. PubMed ID: 12480931