Details for: ATP5F1B

Gene ID: 506

Symbol: ATP5F1B

Ensembl ID: ENSG00000110955

Description: ATP synthase F1 subunit beta

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 290.8380
    Cell Significance Index: -119.8100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 264.9061
    Cell Significance Index: -107.6200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 253.2816
    Cell Significance Index: -119.5800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 231.6552
    Cell Significance Index: -119.1600
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 178.2355
    Cell Significance Index: -119.6000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 112.7529
    Cell Significance Index: -107.6500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 26.6979
    Cell Significance Index: -71.5200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 26.0007
    Cell Significance Index: -79.8600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 16.3987
    Cell Significance Index: -35.8900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 6.4922
    Cell Significance Index: 51.8400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 6.0022
    Cell Significance Index: 315.1400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 4.2083
    Cell Significance Index: 45.7500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 3.9823
    Cell Significance Index: 104.7200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 3.7130
    Cell Significance Index: 77.7200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 3.4587
    Cell Significance Index: 120.1900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 3.2401
    Cell Significance Index: 54.5800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 3.2351
    Cell Significance Index: 95.0100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 3.2290
    Cell Significance Index: 208.3200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 3.0775
    Cell Significance Index: 554.7700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 2.9165
    Cell Significance Index: 206.2700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.8766
    Cell Significance Index: 371.6300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.7412
    Cell Significance Index: 337.0600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.6268
    Cell Significance Index: 309.7900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.5956
    Cell Significance Index: 70.6500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.5698
    Cell Significance Index: 119.8200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 2.4831
    Cell Significance Index: 1097.8200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.4535
    Cell Significance Index: 1339.9300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.4470
    Cell Significance Index: 336.0500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 2.3520
    Cell Significance Index: 676.7500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 2.1524
    Cell Significance Index: 129.2200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.1361
    Cell Significance Index: 159.2000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.7927
    Cell Significance Index: 229.8100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.4028
    Cell Significance Index: 17.9700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.3566
    Cell Significance Index: 70.4700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.3113
    Cell Significance Index: 61.6300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.2743
    Cell Significance Index: 11.7400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.1451
    Cell Significance Index: 227.2400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0517
    Cell Significance Index: 210.9600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.0380
    Cell Significance Index: 65.4200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.7855
    Cell Significance Index: 13.8800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7820
    Cell Significance Index: 77.3600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6620
    Cell Significance Index: 107.6700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.5747
    Cell Significance Index: 16.0600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.5667
    Cell Significance Index: 415.5100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4273
    Cell Significance Index: 153.2800
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.3704
    Cell Significance Index: 2.8600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.3213
    Cell Significance Index: 3.6500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.2202
    Cell Significance Index: 4.0700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 0.1472
    Cell Significance Index: 11.6600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0990
    Cell Significance Index: 3.4800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0877
    Cell Significance Index: 66.4000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0509
    Cell Significance Index: 1.3600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0136
    Cell Significance Index: -25.6200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0347
    Cell Significance Index: -0.5800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0385
    Cell Significance Index: -1.1100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0402
    Cell Significance Index: -4.1100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0471
    Cell Significance Index: -86.8100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0702
    Cell Significance Index: -108.1100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0788
    Cell Significance Index: -15.0100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0809
    Cell Significance Index: -51.3500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0876
    Cell Significance Index: -4.4300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0927
    Cell Significance Index: -126.0200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1322
    Cell Significance Index: -97.9400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1384
    Cell Significance Index: -62.8200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1565
    Cell Significance Index: -26.7300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1681
    Cell Significance Index: -7.6200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1750
    Cell Significance Index: -13.4300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1807
    Cell Significance Index: -101.9300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1912
    Cell Significance Index: -21.9100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.2076
    Cell Significance Index: -129.6500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2092
    Cell Significance Index: -3.5900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2229
    Cell Significance Index: -6.3900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2445
    Cell Significance Index: -7.8300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3269
    Cell Significance Index: -13.3900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.3571
    Cell Significance Index: -24.7000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.5027
    Cell Significance Index: -73.0700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.5985
    Cell Significance Index: -126.0600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.6134
    Cell Significance Index: -71.4900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.6330
    Cell Significance Index: -16.1700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.7316
    Cell Significance Index: -15.8500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.7676
    Cell Significance Index: -47.1800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.0815
    Cell Significance Index: -112.6100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -1.0956
    Cell Significance Index: -13.0600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.2294
    Cell Significance Index: -68.9900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.3557
    Cell Significance Index: -39.9300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -1.4656
    Cell Significance Index: -21.9600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.5531
    Cell Significance Index: -21.1900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.6309
    Cell Significance Index: -99.9900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -1.6365
    Cell Significance Index: -24.1600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -1.8282
    Cell Significance Index: -95.2300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -1.9893
    Cell Significance Index: -16.7100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -2.2169
    Cell Significance Index: -54.0900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -2.2558
    Cell Significance Index: -99.7800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -2.5287
    Cell Significance Index: -55.3700
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -2.5504
    Cell Significance Index: -53.1900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -2.5799
    Cell Significance Index: -66.3200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -2.6553
    Cell Significance Index: -97.4800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -2.7055
    Cell Significance Index: -94.7800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -2.7203
    Cell Significance Index: -103.0100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -2.8068
    Cell Significance Index: -91.9000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Function:** ATP5F1B is a mitochondrial enzyme that catalyzes the synthesis of ATP from ADP and inorganic phosphate, using the proton gradient generated by the electron transport chain. 2. **Structure:** The beta subunit of the F1 complex is composed of six transmembrane alpha helices and a central stalk that connects to the F0 complex, which spans the mitochondrial inner membrane. 3. **Expression:** ATP5F1B is highly expressed in cells with high energy demands, such as skeletal muscle, cardiac muscle, and pancreatic acinar cells. 4. **Regulation:** The gene is regulated by various transcriptional factors, including PGC-1α, which promotes mitochondrial biogenesis and function. **Pathways and Functions:** 1. **Mitochondrial Biogenesis:** ATP5F1B is involved in the regulation of mitochondrial biogenesis, particularly through the transcriptional activation of mitochondrial biogenesis by PGC-1α. 2. **Angiogenesis:** The ATP5F1B gene is involved in angiogenesis, a process critical for tissue repair and development, through the regulation of cell migration and adhesion. 3. **Cell Migration:** ATP5F1B is involved in the regulation of cell migration, particularly in the context of blood vessel endothelial cell migration. 4. **Citric Acid Cycle and Respiratory Electron Transport:** The ATP5F1B gene is involved in the regulation of the citric acid cycle and respiratory electron transport, critical for energy production in cells. 5. **Heat Production:** ATP5F1B is also involved in heat production by uncoupling proteins, which can be beneficial in certain physiological contexts. **Clinical Significance:** 1. **Mitochondrial Diseases:** Mutations in the ATP5F1B gene have been associated with mitochondrial diseases, such as Kearns-Sayre syndrome and MELAS syndrome. 2. **Cancer:** The ATP5F1B gene is overexpressed in certain types of cancer, including breast cancer and lung cancer, and has been implicated in cancer progression and metastasis. 3. **Cardiovascular Disease:** The ATP5F1B gene is involved in the regulation of cardiac function and has been implicated in the development of cardiovascular disease, particularly in the context of hypertension and atherosclerosis. 4. **Neurodegenerative Diseases:** The ATP5F1B gene has been implicated in the regulation of energy homeostasis in the brain and has been associated with neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. In conclusion, the ATP5F1B gene plays a critical role in maintaining energy homeostasis, regulating cell migration, and modulating the citric acid cycle and respiratory electron transport. Its dysregulation has been implicated in various diseases, including mitochondrial diseases, cancer, cardiovascular disease, and neurodegenerative diseases. Further research is needed to fully elucidate the functional significance of the ATP5F1B gene and its role in human disease.

Genular Protein ID: 2711999557

Symbol: ATPB_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2687158

Title: The human ATP synthase beta subunit gene: sequence analysis, chromosome assignment, and differential expression.

PubMed ID: 2687158

DOI: 10.1016/0888-7543(89)90125-0

PubMed ID: 2900241

Title: Gene structure of the human mitochondrial adenosine triphosphate synthase beta subunit.

PubMed ID: 2900241

DOI: 10.1016/s0021-9258(18)37950-x

PubMed ID: 2870059

Title: Human F1-ATPase: molecular cloning of cDNA for the beta subunit.

PubMed ID: 2870059

DOI: 10.1093/oxfordjournals.jbchem.a135452

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19892738

Title: Global profiling of protease cleavage sites by chemoselective labeling of protein N-termini.

PubMed ID: 19892738

DOI: 10.1073/pnas.0908958106

PubMed ID: 2896550

Title: Sequence analysis of cDNAs for the human and bovine ATP synthase beta subunit: mitochondrial DNA genes sustain seventeen times more mutations.

PubMed ID: 2896550

DOI: 10.1007/bf00434661

PubMed ID: 15242332

Title: Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes.

PubMed ID: 15242332

DOI: 10.1042/bj20040647

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25168243

Title: Cofactor Strap regulates oxidative phosphorylation and mitochondrial p53 activity through ATP synthase.

PubMed ID: 25168243

DOI: 10.1038/cdd.2014.135

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 32243843

Title: Mitoregulin Controls beta-Oxidation in Human and Mouse Adipocytes.

PubMed ID: 32243843

DOI: 10.1016/j.stemcr.2020.03.002

PubMed ID: 36239646

Title: Congenital hypermetabolism and uncoupled oxidative phosphorylation.

PubMed ID: 36239646

DOI: 10.1056/nejmoa2202949

PubMed ID: 25787250

Title: Neomorphic effects of recurrent somatic mutations in Yin Yang 1 in insulin-producing adenomas.

PubMed ID: 25787250

DOI: 10.1073/pnas.1503696112

Sequence Information:

  • Length: 529
  • Mass: 56560
  • Checksum: 960C616A2252B91A
  • Sequence:
  • MLGFVGRVAA APASGALRRL TPSASLPPAQ LLLRAAPTAV HPVRDYAAQT SPSPKAGAAT 
    GRIVAVIGAV VDVQFDEGLP PILNALEVQG RETRLVLEVA QHLGESTVRT IAMDGTEGLV 
    RGQKVLDSGA PIKIPVGPET LGRIMNVIGE PIDERGPIKT KQFAPIHAEA PEFMEMSVEQ 
    EILVTGIKVV DLLAPYAKGG KIGLFGGAGV GKTVLIMELI NNVAKAHGGY SVFAGVGERT 
    REGNDLYHEM IESGVINLKD ATSKVALVYG QMNEPPGARA RVALTGLTVA EYFRDQEGQD 
    VLLFIDNIFR FTQAGSEVSA LLGRIPSAVG YQPTLATDMG TMQERITTTK KGSITSVQAI 
    YVPADDLTDP APATTFAHLD ATTVLSRAIA ELGIYPAVDP LDSTSRIMDP NIVGSEHYDV 
    ARGVQKILQD YKSLQDIIAI LGMDELSEED KLTVSRARKI QRFLSQPFQV AEVFTGHMGK 
    LVPLKETIKG FQQILAGEYD HLPEQAFYMV GPIEEAVAKA DKLAEEHSS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.