Details for: ATP5F1B

Gene ID: 506

Symbol: ATP5F1B

Ensembl ID: ENSG00000110955

Description: ATP synthase F1 subunit beta

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    CSI Score: 7.4
  • Cell Name: slow muscle cell (CL0000189)
    CSI Score: 6.1
  • Cell Name: conjunctival epithelial cell (CL1000432)
    CSI Score: 5.5
  • Cell Name: colon epithelial cell (CL0011108)
    CSI Score: 4.1
  • Cell Name: transit amplifying cell (CL0009010)
    CSI Score: 4.1
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    CSI Score: 4.1
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    CSI Score: 3.8
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    CSI Score: 3.7
  • Cell Name: malignant cell (CL0001064)
    CSI Score: 3.6
  • Cell Name: pancreatic ductal cell (CL0002079)
    CSI Score: 3.4
  • Cell Name: myeloid leukocyte (CL0000766)
    CSI Score: 3.4
  • Cell Name: colonocyte (CL1000347)
    CSI Score: 3.2
  • Cell Name: kidney epithelial cell (CL0002518)
    CSI Score: 3.2
  • Cell Name: obsolete animal cell (CL0000548)
    CSI Score: 3.2
  • Cell Name: peripheral nervous system neuron (CL2000032)
    CSI Score: 3.1
  • Cell Name: exhausted T cell (CL0011025)
    CSI Score: 3.1
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    CSI Score: 2.8
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    CSI Score: 2.7
  • Cell Name: neuron (CL0000540)
    CSI Score: 2.6
  • Cell Name: enterocyte (CL0000584)
    CSI Score: 2.5
  • Cell Name: placental villous trophoblast (CL2000060)
    CSI Score: 2.5
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    CSI Score: 2.5
  • Cell Name: pancreatic acinar cell (CL0002064)
    CSI Score: 2.4
  • Cell Name: mesenchymal cell (CL0008019)
    CSI Score: 2.4
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    CSI Score: 2.4
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    CSI Score: 2.3
  • Cell Name: glial cell (CL0000125)
    CSI Score: 2.3
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    CSI Score: 2.3
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    CSI Score: 2.2
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    CSI Score: 2.2
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    CSI Score: 2.2
  • Cell Name: GABAergic neuron (CL0000617)
    CSI Score: 2.2
  • Cell Name: OFF-bipolar cell (CL0000750)
    CSI Score: 2.2
  • Cell Name: glioblast (CL0000030)
    CSI Score: 2.2
  • Cell Name: secretory cell (CL0000151)
    CSI Score: 2.1
  • Cell Name: ON-bipolar cell (CL0000749)
    CSI Score: 2.1
  • Cell Name: retinal rod cell (CL0000604)
    CSI Score: 2.0
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    CSI Score: 2.0
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    CSI Score: 2.0
  • Cell Name: classical monocyte (CL0000860)
    CSI Score: 1.9
  • Cell Name: corneal epithelial cell (CL0000575)
    CSI Score: 1.8
  • Cell Name: Hofbauer cell (CL3000001)
    CSI Score: 1.8
  • Cell Name: ciliated epithelial cell (CL0000067)
    CSI Score: 1.8
  • Cell Name: mesodermal cell (CL0000222)
    CSI Score: 1.7
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    CSI Score: 1.7
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    CSI Score: 1.7
  • Cell Name: muscle cell (CL0000187)
    CSI Score: 1.7
  • Cell Name: intestinal epithelial cell (CL0002563)
    CSI Score: 1.6
  • Cell Name: mesenchymal stem cell (CL0000134)
    CSI Score: 1.6
  • Cell Name: stem cell (CL0000034)
    CSI Score: 1.6
  • Cell Name: cardiac muscle cell (CL0000746)
    CSI Score: 1.6
  • Cell Name: enteric smooth muscle cell (CL0002504)
    CSI Score: 1.5
  • Cell Name: ciliated cell (CL0000064)
    CSI Score: 1.5
  • Cell Name: myeloid cell (CL0000763)
    CSI Score: 1.5
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    CSI Score: 1.5
  • Cell Name: keratinocyte (CL0000312)
    CSI Score: 1.4
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    CSI Score: 1.4
  • Cell Name: glutamatergic neuron (CL0000679)
    CSI Score: 1.4
  • Cell Name: lung ciliated cell (CL1000271)
    CSI Score: 1.3
  • Cell Name: mature alpha-beta T cell (CL0000791)
    CSI Score: 1.3
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    CSI Score: 1.3
  • Cell Name: blood cell (CL0000081)
    CSI Score: 1.3
  • Cell Name: transit amplifying cell of colon (CL0009011)
    CSI Score: 1.2
  • Cell Name: renal intercalated cell (CL0005010)
    CSI Score: 1.2
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    CSI Score: 1.2
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    CSI Score: 1.2
  • Cell Name: keratocyte (CL0002363)
    CSI Score: 1.2
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    CSI Score: 1.2
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    CSI Score: 1.1
  • Cell Name: goblet cell (CL0000160)
    CSI Score: 1.1
  • Cell Name: macrophage (CL0000235)
    CSI Score: 1.1
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    CSI Score: 1.1
  • Cell Name: mononuclear phagocyte (CL0000113)
    CSI Score: 1.1
  • Cell Name: Mueller cell (CL0000636)
    CSI Score: 1.0
  • Cell Name: T cell (CL0000084)
    CSI Score: 1.0
  • Cell Name: naive T cell (CL0000898)
    CSI Score: 1.0
  • Cell Name: oligodendrocyte (CL0000128)
    CSI Score: 0.9
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    CSI Score: 0.9
  • Cell Name: neural progenitor cell (CL0011020)
    CSI Score: 0.9
  • Cell Name: tracheal goblet cell (CL1000329)
    CSI Score: 0.9
  • Cell Name: CD14-positive monocyte (CL0001054)
    CSI Score: 0.8
  • Cell Name: type I NK T cell (CL0000921)
    CSI Score: 0.8
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    CSI Score: 0.8
  • Cell Name: melanocyte (CL0000148)
    CSI Score: 0.8
  • Cell Name: basal cell (CL0000646)
    CSI Score: 0.8
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    CSI Score: 0.7
  • Cell Name: CD4-positive helper T cell (CL0000492)
    CSI Score: 0.7
  • Cell Name: promonocyte (CL0000559)
    CSI Score: 0.7
  • Cell Name: epithelial cell (CL0000066)
    CSI Score: 0.7
  • Cell Name: hepatocyte (CL0000182)
    CSI Score: 0.7
  • Cell Name: memory B cell (CL0000787)
    CSI Score: 0.7
  • Cell Name: naive B cell (CL0000788)
    CSI Score: 0.7
  • Cell Name: alveolar macrophage (CL0000583)
    CSI Score: 0.7
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    CSI Score: 0.7
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    CSI Score: 0.6
  • Cell Name: mature NK T cell (CL0000814)
    CSI Score: 0.6
  • Cell Name: brush cell (CL0002204)
    CSI Score: 0.6
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    CSI Score: 0.6
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    CSI Score: 0.6
  • Cell Name: cardiac endothelial cell (CL0010008)
    CSI Score: 0.6

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Function:** ATP5F1B is a mitochondrial enzyme that catalyzes the synthesis of ATP from ADP and inorganic phosphate, using the proton gradient generated by the electron transport chain. 2. **Structure:** The beta subunit of the F1 complex is composed of six transmembrane alpha helices and a central stalk that connects to the F0 complex, which spans the mitochondrial inner membrane. 3. **Expression:** ATP5F1B is highly expressed in cells with high energy demands, such as skeletal muscle, cardiac muscle, and pancreatic acinar cells. 4. **Regulation:** The gene is regulated by various transcriptional factors, including PGC-1α, which promotes mitochondrial biogenesis and function. **Pathways and Functions:** 1. **Mitochondrial Biogenesis:** ATP5F1B is involved in the regulation of mitochondrial biogenesis, particularly through the transcriptional activation of mitochondrial biogenesis by PGC-1α. 2. **Angiogenesis:** The ATP5F1B gene is involved in angiogenesis, a process critical for tissue repair and development, through the regulation of cell migration and adhesion. 3. **Cell Migration:** ATP5F1B is involved in the regulation of cell migration, particularly in the context of blood vessel endothelial cell migration. 4. **Citric Acid Cycle and Respiratory Electron Transport:** The ATP5F1B gene is involved in the regulation of the citric acid cycle and respiratory electron transport, critical for energy production in cells. 5. **Heat Production:** ATP5F1B is also involved in heat production by uncoupling proteins, which can be beneficial in certain physiological contexts. **Clinical Significance:** 1. **Mitochondrial Diseases:** Mutations in the ATP5F1B gene have been associated with mitochondrial diseases, such as Kearns-Sayre syndrome and MELAS syndrome. 2. **Cancer:** The ATP5F1B gene is overexpressed in certain types of cancer, including breast cancer and lung cancer, and has been implicated in cancer progression and metastasis. 3. **Cardiovascular Disease:** The ATP5F1B gene is involved in the regulation of cardiac function and has been implicated in the development of cardiovascular disease, particularly in the context of hypertension and atherosclerosis. 4. **Neurodegenerative Diseases:** The ATP5F1B gene has been implicated in the regulation of energy homeostasis in the brain and has been associated with neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. In conclusion, the ATP5F1B gene plays a critical role in maintaining energy homeostasis, regulating cell migration, and modulating the citric acid cycle and respiratory electron transport. Its dysregulation has been implicated in various diseases, including mitochondrial diseases, cancer, cardiovascular disease, and neurodegenerative diseases. Further research is needed to fully elucidate the functional significance of the ATP5F1B gene and its role in human disease.

Genular Protein ID: 2711999557

Symbol: ATPB_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2687158

Title: The human ATP synthase beta subunit gene: sequence analysis, chromosome assignment, and differential expression.

PubMed ID: 2687158

DOI: 10.1016/0888-7543(89)90125-0

PubMed ID: 2900241

Title: Gene structure of the human mitochondrial adenosine triphosphate synthase beta subunit.

PubMed ID: 2900241

DOI: 10.1016/s0021-9258(18)37950-x

PubMed ID: 2870059

Title: Human F1-ATPase: molecular cloning of cDNA for the beta subunit.

PubMed ID: 2870059

DOI: 10.1093/oxfordjournals.jbchem.a135452

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19892738

Title: Global profiling of protease cleavage sites by chemoselective labeling of protein N-termini.

PubMed ID: 19892738

DOI: 10.1073/pnas.0908958106

PubMed ID: 2896550

Title: Sequence analysis of cDNAs for the human and bovine ATP synthase beta subunit: mitochondrial DNA genes sustain seventeen times more mutations.

PubMed ID: 2896550

DOI: 10.1007/bf00434661

PubMed ID: 15242332

Title: Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes.

PubMed ID: 15242332

DOI: 10.1042/bj20040647

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25168243

Title: Cofactor Strap regulates oxidative phosphorylation and mitochondrial p53 activity through ATP synthase.

PubMed ID: 25168243

DOI: 10.1038/cdd.2014.135

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 32243843

Title: Mitoregulin Controls beta-Oxidation in Human and Mouse Adipocytes.

PubMed ID: 32243843

DOI: 10.1016/j.stemcr.2020.03.002

PubMed ID: 36239646

Title: Congenital hypermetabolism and uncoupled oxidative phosphorylation.

PubMed ID: 36239646

DOI: 10.1056/nejmoa2202949

PubMed ID: 25787250

Title: Neomorphic effects of recurrent somatic mutations in Yin Yang 1 in insulin-producing adenomas.

PubMed ID: 25787250

DOI: 10.1073/pnas.1503696112

Sequence Information:

  • Length: 529
  • Mass: 56560
  • Checksum: 960C616A2252B91A
  • Sequence:
  • MLGFVGRVAA APASGALRRL TPSASLPPAQ LLLRAAPTAV HPVRDYAAQT SPSPKAGAAT 
    GRIVAVIGAV VDVQFDEGLP PILNALEVQG RETRLVLEVA QHLGESTVRT IAMDGTEGLV 
    RGQKVLDSGA PIKIPVGPET LGRIMNVIGE PIDERGPIKT KQFAPIHAEA PEFMEMSVEQ 
    EILVTGIKVV DLLAPYAKGG KIGLFGGAGV GKTVLIMELI NNVAKAHGGY SVFAGVGERT 
    REGNDLYHEM IESGVINLKD ATSKVALVYG QMNEPPGARA RVALTGLTVA EYFRDQEGQD 
    VLLFIDNIFR FTQAGSEVSA LLGRIPSAVG YQPTLATDMG TMQERITTTK KGSITSVQAI 
    YVPADDLTDP APATTFAHLD ATTVLSRAIA ELGIYPAVDP LDSTSRIMDP NIVGSEHYDV 
    ARGVQKILQD YKSLQDIIAI LGMDELSEED KLTVSRARKI QRFLSQPFQV AEVFTGHMGK 
    LVPLKETIKG FQQILAGEYD HLPEQAFYMV GPIEEAVAKA DKLAEEHSS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.