Details for: ATP5F1B

Gene ID: 506

Symbol: ATP5F1B

Ensembl ID: ENSG00000110955

Description: ATP synthase F1 subunit beta

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 6.74
    Marker Score: 4511
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 4.44
    Marker Score: 3136
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 4.36
    Marker Score: 2645
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 4.13
    Marker Score: 1211
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 4.02
    Marker Score: 8476
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 3.82
    Marker Score: 10244
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 3.82
    Marker Score: 4141
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 3.73
    Marker Score: 49553
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 3.58
    Marker Score: 3199
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 3.46
    Marker Score: 1846
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 3.46
    Marker Score: 14361
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 3.45
    Marker Score: 2926
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 3.37
    Marker Score: 8508
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.37
    Marker Score: 4071
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 3.3
    Marker Score: 1368
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 3.26
    Marker Score: 3396
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 3.23
    Marker Score: 2440
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 3.23
    Marker Score: 5350
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 3.17
    Marker Score: 9956
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 3.17
    Marker Score: 41811
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 3.14
    Marker Score: 2966.5
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.12
    Marker Score: 7622.5
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 3.03
    Marker Score: 10771
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.98
    Marker Score: 29523
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.95
    Marker Score: 2952
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.94
    Marker Score: 34136
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.92
    Marker Score: 18962
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.91
    Marker Score: 21636
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.9
    Marker Score: 4106.5
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 2.89
    Marker Score: 1539
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 2.89
    Marker Score: 3063
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 2.88
    Marker Score: 1606
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 2.88
    Marker Score: 947
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 2.86
    Marker Score: 3379
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.8
    Marker Score: 24169
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.8
    Marker Score: 2990
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.8
    Marker Score: 13430
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.79
    Marker Score: 156069
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.78
    Marker Score: 21741
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.78
    Marker Score: 5654.5
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.77
    Marker Score: 1738
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 2.77
    Marker Score: 1621
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 2.75
    Marker Score: 3893
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 2.73
    Marker Score: 3786
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.73
    Marker Score: 5690.5
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.72
    Marker Score: 4462.5
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.72
    Marker Score: 11121
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 2.71
    Marker Score: 8564
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 2.71
    Marker Score: 16055
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.68
    Marker Score: 2108
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 2.65
    Marker Score: 1747
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.65
    Marker Score: 2691
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.64
    Marker Score: 5151
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.64
    Marker Score: 7303
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.64
    Marker Score: 26779
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.63
    Marker Score: 91214
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.63
    Marker Score: 4186
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.63
    Marker Score: 4937
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 2.63
    Marker Score: 35283
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 2.62
    Marker Score: 1744
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 2.62
    Marker Score: 1553
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.61
    Marker Score: 624
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 2.6
    Marker Score: 4647
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 2.6
    Marker Score: 2700
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.59
    Marker Score: 11188
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.59
    Marker Score: 16572
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 2.58
    Marker Score: 3975
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.58
    Marker Score: 9932
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.57
    Marker Score: 4372
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.57
    Marker Score: 2416
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.56
    Marker Score: 2876
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.55
    Marker Score: 2724.5
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 2.54
    Marker Score: 7253
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 2.54
    Marker Score: 1206
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.54
    Marker Score: 6916
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 2.53
    Marker Score: 2382
  • Cell Name: Unknown (CL0000548)
    Fold Change: 2.52
    Marker Score: 1839
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 2.51
    Marker Score: 1184
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 2.51
    Marker Score: 2422
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 2.48
    Marker Score: 2177.5
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.48
    Marker Score: 7345
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 2.47
    Marker Score: 736
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.45
    Marker Score: 83395
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 2.45
    Marker Score: 2468
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.45
    Marker Score: 4270
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.44
    Marker Score: 21211
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.44
    Marker Score: 5735.5
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.43
    Marker Score: 1623
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 2.43
    Marker Score: 2329
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.43
    Marker Score: 24451
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 2.42
    Marker Score: 3498
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 2.41
    Marker Score: 1371
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 2.41
    Marker Score: 1747
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.4
    Marker Score: 127027
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.4
    Marker Score: 2746
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.39
    Marker Score: 5456
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 2.39
    Marker Score: 3681
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 2.37
    Marker Score: 10177
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 2.37
    Marker Score: 2287
  • Cell Name: Unknown (CL0002371)
    Fold Change: 2.36
    Marker Score: 2509

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Other Information

**Key characteristics:** * Protein type: Protein * Ensembl ID: ENSG00000110955 * Pathway/Ontology: Angiostatin binding, Atp binding, Atp hydrolysis activity, Cristae formation, Formation of ATP by chemiosmotic coupling, Metabolism, Metabolism of proteins, Mhc class i protein binding, Mitochondrial biogenesis, Mitochondrial protein degradation, Mitochondrial protein import, Organelle biogenesis and maintenance, Protein binding, Protein localization, Proton-transporting atp synthase activity, rotational mechanism, Respiratory electron transport, atp synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. **Pathways and functions:** * The gene encodes for the ATP synthase F1 subunit beta, which is a protein that is located on the surface of mitochondria. * The protein is responsible for the regulation of cellular energy production by controlling the flow of protons across the mitochondrial membrane. * When ATP synthase F1 subunit beta binds to ADP and inorganic phosphate, it opens the mitochondrial membrane, allowing protons to flow from the mitochondrial matrix to the intermembrane space. * This flow of protons creates a proton gradient, which is used by the mitochondrial ATP synthase complex to synthesize ATP from ADP and inorganic phosphate. **Clinical significance:** * Mutations in ATP synthase F1 subunit beta have been linked to a number of human diseases, including mitochondrial disorders and cancer. * These diseases are characterized by a decrease in mitochondrial function, which can lead to energy depletion and cell death. * Targeting ATP synthase F1 subunit beta is a promising therapeutic strategy for these diseases.

Genular Protein ID: 2711999557

Symbol: ATPB_HUMAN

Name: N/A

UniProtKB Accession Codes:

P06576 A8K4X0 Q14283

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CORUM 1 CPTAC 2 CTD 1 CarbonylDB 1 ChEBI 7 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DOSAC-COBS-2DPAGE 1 DisGeNET 1 DrugBank 7 EC 2 EMBL 9 EMDB 8 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 32 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HAMAP 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 8 PIR 1 PIRSF 1 PRIDE 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 2 RNAct 1 Reactome 4 RefSeq 1 Rhea 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 3 SWISS-2DPAGE 1 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCD-2DPAGE 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2687158

Title: The human ATP synthase beta subunit gene: sequence analysis, chromosome assignment, and differential expression.

PubMed ID: 2687158

DOI: 10.1016/0888-7543(89)90125-0

PubMed ID: 2900241

Title: Gene structure of the human mitochondrial adenosine triphosphate synthase beta subunit.

PubMed ID: 2900241

DOI: 10.1016/s0021-9258(18)37950-x

PubMed ID: 2870059

Title: Human F1-ATPase: molecular cloning of cDNA for the beta subunit.

PubMed ID: 2870059

DOI: 10.1093/oxfordjournals.jbchem.a135452

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19892738

Title: Global profiling of protease cleavage sites by chemoselective labeling of protein N-termini.

PubMed ID: 19892738

DOI: 10.1073/pnas.0908958106

PubMed ID: 2896550

Title: Sequence analysis of cDNAs for the human and bovine ATP synthase beta subunit: mitochondrial DNA genes sustain seventeen times more mutations.

PubMed ID: 2896550

DOI: 10.1007/bf00434661

PubMed ID: 15242332

Title: Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes.

PubMed ID: 15242332

DOI: 10.1042/bj20040647

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25168243

Title: Cofactor Strap regulates oxidative phosphorylation and mitochondrial p53 activity through ATP synthase.

PubMed ID: 25168243

DOI: 10.1038/cdd.2014.135

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 32243843

Title: Mitoregulin Controls beta-Oxidation in Human and Mouse Adipocytes.

PubMed ID: 32243843

DOI: 10.1016/j.stemcr.2020.03.002

PubMed ID: 36239646

Title: Congenital hypermetabolism and uncoupled oxidative phosphorylation.

PubMed ID: 36239646

DOI: 10.1056/nejmoa2202949

PubMed ID: 25787250

Title: Neomorphic effects of recurrent somatic mutations in Yin Yang 1 in insulin-producing adenomas.

PubMed ID: 25787250

DOI: 10.1073/pnas.1503696112

Sequence Information:

  • Length: 529
  • Mass: 56560
  • Checksum: 960C616A2252B91A
  • Sequence:
    • MLGFVGRVAA APASGALRRL TPSASLPPAQ LLLRAAPTAV HPVRDYAAQT SPSPKAGAAT 
GRIVAVIGAV VDVQFDEGLP PILNALEVQG RETRLVLEVA QHLGESTVRT IAMDGTEGLV 
RGQKVLDSGA PIKIPVGPET LGRIMNVIGE PIDERGPIKT KQFAPIHAEA PEFMEMSVEQ 
EILVTGIKVV DLLAPYAKGG KIGLFGGAGV GKTVLIMELI NNVAKAHGGY SVFAGVGERT 
REGNDLYHEM IESGVINLKD ATSKVALVYG QMNEPPGARA RVALTGLTVA EYFRDQEGQD 
VLLFIDNIFR FTQAGSEVSA LLGRIPSAVG YQPTLATDMG TMQERITTTK KGSITSVQAI 
YVPADDLTDP APATTFAHLD ATTVLSRAIA ELGIYPAVDP LDSTSRIMDP NIVGSEHYDV 
ARGVQKILQD YKSLQDIIAI LGMDELSEED KLTVSRARKI QRFLSQPFQV AEVFTGHMGK 
LVPLKETIKG FQQILAGEYD HLPEQAFYMV GPIEEAVAKA DKLAEEHSS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.