Details for: ABL2

Gene ID: 27

Symbol: ABL2

Ensembl ID: ENSG00000143322

Description: ABL proto-oncogene 2, non-receptor tyrosine kinase

Associated with

Cells (max top 100)

  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.86
    Marker Score: 97368
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.28
    Marker Score: 5004
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.14
    Marker Score: 81454
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.04
    Marker Score: 15631
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 2.01
    Marker Score: 2501
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.9
    Marker Score: 117119
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.89
    Marker Score: 17754
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.87
    Marker Score: 2719
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.87
    Marker Score: 7616.5
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.85
    Marker Score: 27604
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.81
    Marker Score: 7001
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.8
    Marker Score: 1024
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.78
    Marker Score: 16916
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.76
    Marker Score: 37640
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.73
    Marker Score: 14826
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.7
    Marker Score: 4848
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.69
    Marker Score: 7012
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.68
    Marker Score: 61903
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.65
    Marker Score: 55670
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.62
    Marker Score: 32226
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.62
    Marker Score: 16707
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.58
    Marker Score: 3040
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 1.53
    Marker Score: 1155
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.53
    Marker Score: 912
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.53
    Marker Score: 635
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 1.52
    Marker Score: 557
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 1.51
    Marker Score: 7932
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 1.51
    Marker Score: 8090
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.49
    Marker Score: 2304
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167597
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.38
    Marker Score: 404
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.38
    Marker Score: 6395
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.35
    Marker Score: 757
  • Cell Name: granule cell (CL0000120)
    Fold Change: 1.34
    Marker Score: 10108
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.33
    Marker Score: 1526
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 1.31
    Marker Score: 3017
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.31
    Marker Score: 691
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 1.31
    Marker Score: 4387
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.31
    Marker Score: 1410
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.3
    Marker Score: 1497
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.3
    Marker Score: 530
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.28
    Marker Score: 538
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.26
    Marker Score: 5253.5
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.25
    Marker Score: 311
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.24
    Marker Score: 2085
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.24
    Marker Score: 311
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.2
    Marker Score: 923
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.18
    Marker Score: 742
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.17
    Marker Score: 1010
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.15
    Marker Score: 29576
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.15
    Marker Score: 560
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.15
    Marker Score: 756
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.13
    Marker Score: 408
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.13
    Marker Score: 2702
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 1.12
    Marker Score: 410
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.12
    Marker Score: 270
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.12
    Marker Score: 653
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.11
    Marker Score: 1226
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.08
    Marker Score: 17376
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.08
    Marker Score: 3537
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.08
    Marker Score: 437
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.08
    Marker Score: 4482
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.07
    Marker Score: 2145
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.07
    Marker Score: 535
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.07
    Marker Score: 416
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.07
    Marker Score: 6884
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.07
    Marker Score: 6504.5
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.07
    Marker Score: 2521
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.05
    Marker Score: 589
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251669
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.04
    Marker Score: 2688
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.03
    Marker Score: 558
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.02
    Marker Score: 330
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.02
    Marker Score: 918
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.02
    Marker Score: 528
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.02
    Marker Score: 591
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.02
    Marker Score: 22729
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.01
    Marker Score: 17976
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.01
    Marker Score: 964
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.01
    Marker Score: 379
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71691
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47917
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.99
    Marker Score: 490
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.98
    Marker Score: 269
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.98
    Marker Score: 1389
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30390
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.98
    Marker Score: 362
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.98
    Marker Score: 333
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 0.98
    Marker Score: 543
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.97
    Marker Score: 340
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.97
    Marker Score: 15215
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.97
    Marker Score: 1038
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.97
    Marker Score: 1969
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.96
    Marker Score: 852
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.96
    Marker Score: 4122
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.95
    Marker Score: 2499
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.95
    Marker Score: 251
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.95
    Marker Score: 1280
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.95
    Marker Score: 473
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.95
    Marker Score: 329
**Key characteristics:** - ABL2 is a large protein (135 kDa) with seven immunoglobulin domains. - It is a member of the Src family of tyrosine kinases. - It is activated by various growth factors and cytokines. - It phosphorylates various substrates involved in cell cycle regulation, cell survival, and migration. **Pathways and functions:** - ABL2 is involved in various cellular processes, including cell migration, proliferation, and survival. - It is essential for the development and survival of mammary gland epithelial cells. - It is involved in the regulation of ciliary muscle cells, promoting cell cycle arrest and migration. - It plays a role in the development of the nervous system and the growth and survival of neurons. - It is involved in the regulation of vascular endothelial cells, promoting angiogenesis and tumor growth. **Clinical significance:** - Mutations in ABL2 have been linked to various human cancers, including breast cancer, lung cancer, and colon cancer. - Targeting ABL2 has emerged as a promising therapeutic strategy for these cancers. - ABL2 inhibitors are currently being investigated in clinical trials for the treatment of cancer and other diseases. **Additional information:** - ABL2 is a highly conserved protein, with similar sequences found in mammals and birds. - It is a substrate for various phosphatases, including PI3K, MAPK, and Src. - It is a key regulator of cell growth, proliferation, and survival.

Database document:

Only first 5 entries are kept for 'singleCellExpressions', 'mRNAExpressions' and other large data arrays.