Details for: ABL2

Gene ID: 27

Symbol: ABL2

Ensembl ID: ENSG00000143322

Description: ABL proto-oncogene 2, non-receptor tyrosine kinase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 356.3594
    Cell Significance Index: -55.4300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 211.2809
    Cell Significance Index: -53.5900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 119.2063
    Cell Significance Index: -56.2800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 45.0868
    Cell Significance Index: -55.5900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 20.1728
    Cell Significance Index: -54.0400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 16.1474
    Cell Significance Index: -35.3400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 15.5431
    Cell Significance Index: -47.7400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 14.1154
    Cell Significance Index: -55.7000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.7632
    Cell Significance Index: 107.8800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.4537
    Cell Significance Index: 486.9400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.1936
    Cell Significance Index: 440.0300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.9548
    Cell Significance Index: 74.0300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.6657
    Cell Significance Index: 73.6800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.4292
    Cell Significance Index: 512.6500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.2778
    Cell Significance Index: 883.8000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.1999
    Cell Significance Index: 67.3300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.1462
    Cell Significance Index: 22.3700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.1004
    Cell Significance Index: 73.9900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.8118
    Cell Significance Index: 62.3000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8115
    Cell Significance Index: 732.7100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.7432
    Cell Significance Index: 21.2100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.6726
    Cell Significance Index: 17.2900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.6133
    Cell Significance Index: 15.3300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.5155
    Cell Significance Index: 60.0800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.4526
    Cell Significance Index: 282.6200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.4266
    Cell Significance Index: 26.2200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3434
    Cell Significance Index: 37.3500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3009
    Cell Significance Index: 57.2700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2859
    Cell Significance Index: 35.1500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.2661
    Cell Significance Index: 120.7800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2474
    Cell Significance Index: 4.2400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2386
    Cell Significance Index: 38.8100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1827
    Cell Significance Index: 10.9700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1496
    Cell Significance Index: 26.9700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1492
    Cell Significance Index: 4.3000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1285
    Cell Significance Index: 12.7100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1263
    Cell Significance Index: 68.9500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1121
    Cell Significance Index: 5.2700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1076
    Cell Significance Index: 202.6100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0952
    Cell Significance Index: 60.4400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0717
    Cell Significance Index: 1.1100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0714
    Cell Significance Index: 31.5800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0435
    Cell Significance Index: 80.1800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0380
    Cell Significance Index: 58.4900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0340
    Cell Significance Index: 5.8100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0324
    Cell Significance Index: 0.9100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0165
    Cell Significance Index: 2.2700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0129
    Cell Significance Index: 17.5300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0065
    Cell Significance Index: -0.4500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0228
    Cell Significance Index: -16.8800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0268
    Cell Significance Index: -0.5800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0359
    Cell Significance Index: -5.2200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0381
    Cell Significance Index: -0.2300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0402
    Cell Significance Index: -5.1900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.0484
    Cell Significance Index: -1.0400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0527
    Cell Significance Index: -38.6600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0548
    Cell Significance Index: -30.8800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0599
    Cell Significance Index: -1.6000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0652
    Cell Significance Index: -49.3400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0940
    Cell Significance Index: -4.2600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1504
    Cell Significance Index: -15.3600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1687
    Cell Significance Index: -35.5400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1690
    Cell Significance Index: -48.6200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1975
    Cell Significance Index: -6.9400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2153
    Cell Significance Index: -27.6000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2264
    Cell Significance Index: -5.4300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2278
    Cell Significance Index: -10.6200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2512
    Cell Significance Index: -5.5000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2949
    Cell Significance Index: -2.4100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2961
    Cell Significance Index: -18.6600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3173
    Cell Significance Index: -23.6500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3279
    Cell Significance Index: -37.5700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3681
    Cell Significance Index: -42.0200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3838
    Cell Significance Index: -45.2600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4314
    Cell Significance Index: -44.9200
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.4658
    Cell Significance Index: -6.7000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4861
    Cell Significance Index: -31.3600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.5035
    Cell Significance Index: -35.6100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5736
    Cell Significance Index: -30.1200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.6148
    Cell Significance Index: -10.8700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6190
    Cell Significance Index: -49.0300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.6206
    Cell Significance Index: -7.4000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.6436
    Cell Significance Index: -13.3500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.6465
    Cell Significance Index: -10.8900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.6484
    Cell Significance Index: -17.6500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.6750
    Cell Significance Index: -35.1600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.7780
    Cell Significance Index: -40.4100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7798
    Cell Significance Index: -47.8100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.7977
    Cell Significance Index: -25.5500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.8119
    Cell Significance Index: -10.0700
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.8567
    Cell Significance Index: -13.7500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.8625
    Cell Significance Index: -23.1100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.9123
    Cell Significance Index: -29.8700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.9184
    Cell Significance Index: -29.2500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.9719
    Cell Significance Index: -13.2600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.9771
    Cell Significance Index: -20.8100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -1.0355
    Cell Significance Index: -20.7900
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -1.0616
    Cell Significance Index: -15.2500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -1.1396
    Cell Significance Index: -16.8200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.1459
    Cell Significance Index: -39.8200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The ABL2 protein is a non-receptor tyrosine kinase that belongs to the ABL family of tyrosine kinases. It is a phosphotyrosine residue-binding protein that phosphorylates tyrosine residues on its substrate proteins, leading to the activation of various signaling pathways. The ABL2 protein is characterized by its ability to bind to actin filaments and monomers, as well as its involvement in the regulation of the actin cytoskeleton organization. It is also known to interact with other proteins, including the Rho GTPases, Miro GTPases, and RhobTB3, to regulate their activity. **Pathways and Functions** The ABL2 protein is involved in various cellular processes, including: 1. **Actin Cytoskeleton Organization**: The ABL2 protein regulates the organization of the actin cytoskeleton, which is essential for cell migration, adhesion, and shape. 2. **Cell Migration**: The ABL2 protein is involved in the regulation of cell migration, particularly in the context of T-cell migration and neuron projection development. 3. **Establishment of T-Cell Polarity**: The ABL2 protein is required for the establishment of T-cell polarity, which is essential for the proper functioning of the immune system. 4. **Autophagy**: The ABL2 protein regulates autophagy, a process that involves the degradation of cellular components by lysosomes. 5. **Endocytosis**: The ABL2 protein is involved in the regulation of endocytosis, a process that involves the uptake of cellular components through the cell membrane. 6. **Rho GTPase Signaling**: The ABL2 protein regulates the activity of Rho GTPases, which are involved in the regulation of cell migration, adhesion, and cytoskeleton organization. 7. **Miro GTPase Signaling**: The ABL2 protein regulates the activity of Miro GTPases, which are involved in the regulation of mitochondrial dynamics and the regulation of the actin cytoskeleton. **Clinical Significance** The ABL2 gene has been implicated in various diseases, including: 1. **Leukemia**: The ABL2 gene has been identified as a potential target for the treatment of leukemia, particularly in the context of chronic myeloid leukemia (CML). 2. **Neurological Disorders**: The ABL2 gene has been implicated in the regulation of neuronal development and function, and its dysregulation has been linked to neurological disorders, including autism spectrum disorder and schizophrenia. 3. **Cancer**: The ABL2 gene has been identified as a potential oncogene in various types of cancer, including breast cancer and ovarian cancer. 4. **Immune System Disorders**: The ABL2 gene has been implicated in the regulation of the immune system, and its dysregulation has been linked to immune system disorders, including autoimmune diseases and immunodeficiency diseases. In conclusion, the ABL2 gene plays a crucial role in various cellular processes, including cell adhesion, migration, and signaling pathways. Its dysregulation has been linked to various diseases, including leukemia, neurological disorders, and cancer. Further research is needed to fully understand the role of the ABL2 gene in human disease and to develop effective therapeutic strategies for its dysregulation.

Genular Protein ID: 3014002413

Symbol: ABL2_HUMAN

Name: Tyrosine-protein kinase ABL2

UniProtKB Accession Codes:

P42684 A0M8X0 B7UEF2 B7UEF3 B7UEF4 B7UEF5 Q5T0X6 Q5W0C5 Q6NZY6 Q7Z301

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 7 CDD 3 CORUM 1 CPTAC 2 CTD 1 ChEBI 10 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 5 DrugCentral 1 EC 2 EMBL 13 EMDB 1 Ensembl 7 EvolutionaryTrace 1 GO 31 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 13 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 9 PIR 2 PRINTS 2 PRO 1 PROSITE 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 9 Pumba 1 RNAct 1 Reactome 4 RefSeq 9 Rhea 3 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2198571

Title: The complete coding sequence of arg defines the Abelson subfamily of cytoplasmic tyrosine kinases.

PubMed ID: 2198571

DOI: 10.1073/pnas.87.15.5802

PubMed ID: 18810762

Title: Eight full-length abelson related gene (Arg) isoforms are constitutively expressed in caki-1 cell line and cell distribution of two isoforms has been analyzed after transfection.

PubMed ID: 18810762

DOI: 10.1002/jcb.21922

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3787260

Title: A novel human gene closely related to the abl proto-oncogene.

PubMed ID: 3787260

DOI: 10.1126/science.3787260

PubMed ID: 12748290

Title: Two distinct phosphorylation pathways have additive effects on Abl family kinase activation.

PubMed ID: 12748290

DOI: 10.1128/mcb.23.11.3884-3896.2003

PubMed ID: 15886098

Title: RIN1 is an ABL tyrosine kinase activator and a regulator of epithelial-cell adhesion and migration.

PubMed ID: 15886098

DOI: 10.1016/j.cub.2005.03.049

PubMed ID: 15735735

Title: Ubiquitination and degradation of the Arg tyrosine kinase is regulated by oxidative stress.

PubMed ID: 15735735

DOI: 10.1038/sj.onc.1208454

PubMed ID: 16678104

Title: Interaction between c-Abl and Arg tyrosine kinases and proteasome subunit PSMA7 regulates proteasome degradation.

PubMed ID: 16678104

DOI: 10.1016/j.molcel.2006.04.007

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17306540

Title: A critical role for cortactin phosphorylation by Abl-family kinases in PDGF-induced dorsal-wave formation.

PubMed ID: 17306540

DOI: 10.1016/j.cub.2007.01.057

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18945674

Title: Abl kinases regulate autophagy by promoting the trafficking and function of lysosomal components.

PubMed ID: 18945674

DOI: 10.1074/jbc.m804543200

PubMed ID: 12775773

Title: Regulation of F-actin-dependent processes by the Abl family of tyrosine kinases.

PubMed ID: 12775773

DOI: 10.1242/jcs.00622

PubMed ID: 14729179

Title: How do Abl family kinases regulate cell shape and movement?

PubMed ID: 14729179

DOI: 10.1016/j.tcb.2003.11.003

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18182299

Title: Emerging roles of Abl family tyrosine kinases in microbial pathogenesis.

PubMed ID: 18182299

DOI: 10.1016/j.tibs.2007.10.006

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19381274

Title: Unc119 protects from Shigella infection by inhibiting the Abl family kinases.

PubMed ID: 19381274

DOI: 10.1371/journal.pone.0005211

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 20841568

Title: ABL tyrosine kinases: evolution of function, regulation, and specificity.

PubMed ID: 20841568

DOI: 10.1126/scisignal.3139re6

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 21417343

Title: Crystal structures of ABL-related gene (ABL2) in complex with imatinib, tozasertib (VX-680), and a type I inhibitor of the triazole carbothioamide class.

PubMed ID: 21417343

DOI: 10.1021/jm101506n

PubMed ID: 22297987

Title: Lysozyme contamination facilitates crystallization of a heterotrimeric cortactin-Arg-lysozyme complex.

PubMed ID: 22297987

DOI: 10.1107/s1744309111056132

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 1182
  • Mass: 128343
  • Checksum: ED93869BC2B14FAA
  • Sequence:
    • MGQQVGRVGE APGLQQPQPR GIRGSSAARP SGRRRDPAGR TTETGFNIFT QHDHFASCVE 
DGFEGDKTGG SSPEALHRPY GCDVEPQALN EAIRWSSKEN LLGATESDPN LFVALYDFVA 
SGDNTLSITK GEKLRVLGYN QNGEWSEVRS KNGQGWVPSN YITPVNSLEK HSWYHGPVSR 
SAAEYLLSSL INGSFLVRES ESSPGQLSIS LRYEGRVYHY RINTTADGKV YVTAESRFST 
LAELVHHHST VADGLVTTLH YPAPKCNKPT VYGVSPIHDK WEMERTDITM KHKLGGGQYG 
EVYVGVWKKY SLTVAVKTLK EDTMEVEEFL KEAAVMKEIK HPNLVQLLGV CTLEPPFYIV 
TEYMPYGNLL DYLRECNREE VTAVVLLYMA TQISSAMEYL EKKNFIHRDL AARNCLVGEN 
HVVKVADFGL SRLMTGDTYT AHAGAKFPIK WTAPESLAYN TFSIKSDVWA FGVLLWEIAT 
YGMSPYPGID LSQVYDLLEK GYRMEQPEGC PPKVYELMRA CWKWSPADRP SFAETHQAFE 
TMFHDSSISE EVAEELGRAA SSSSVVPYLP RLPILPSKTR TLKKQVENKE NIEGAQDATE 
NSASSLAPGF IRGAQASSGS PALPRKQRDK SPSSLLEDAK ETCFTRDRKG GFFSSFMKKR 
NAPTPPKRSS SFREMENQPH KKYELTGNFS SVASLQHADG FSFTPAQQEA NLVPPKCYGG 
SFAQRNLCND DGGGGGGSGT AGGGWSGITG FFTPRLIKKT LGLRAGKPTA SDDTSKPFPR 
SNSTSSMSSG LPEQDRMAMT LPRNCQRSKL QLERTVSTSS QPEENVDRAN DMLPKKSEES 
AAPSRERPKA KLLPRGATAL PLRTPSGDLA ITEKDPPGVG VAGVAAAPKG KEKNGGARLG 
MAGVPEDGEQ PGWPSPAKAA PVLPTTHNHK VPVLISPTLK HTPADVQLIG TDSQGNKFKL 
LSEHQVTSSG DKDRPRRVKP KCAPPPPPVM RLLQHPSICS DPTEEPTALT AGQSTSETQE 
GGKKAALGAV PISGKAGRPV MPPPQVPLPT SSISPAKMAN GTAGTKVALR KTKQAAEKIS 
ADKISKEALL ECADLLSSAL TEPVPNSQLV DTGHQLLDYC SGYVDCIPQT RNKFAFREAV 
SKLELSLQEL QVSSAAAGVP GTNPVLNNLL SCVQEISDVV QR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.