Details for: ABL2

Gene ID: 27

Symbol: ABL2

Ensembl ID: ENSG00000143322

Description: ABL proto-oncogene 2, non-receptor tyrosine kinase

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.86
    Marker Score: 97368
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.28
    Marker Score: 5004
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.14
    Marker Score: 81454
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.04
    Marker Score: 15631
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 2.01
    Marker Score: 2501
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.9
    Marker Score: 117119
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.89
    Marker Score: 17754
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.87
    Marker Score: 2719
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.87
    Marker Score: 7616.5
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.85
    Marker Score: 27604
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.81
    Marker Score: 7001
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.8
    Marker Score: 1024
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.78
    Marker Score: 16916
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.76
    Marker Score: 37640
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.73
    Marker Score: 14826
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.7
    Marker Score: 4848
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.69
    Marker Score: 7012
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.68
    Marker Score: 61903
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.65
    Marker Score: 55670
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.62
    Marker Score: 32226
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.62
    Marker Score: 16707
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.58
    Marker Score: 3040
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 1.53
    Marker Score: 1155
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.53
    Marker Score: 912
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.53
    Marker Score: 635
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 1.52
    Marker Score: 557
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 1.51
    Marker Score: 7932
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 1.51
    Marker Score: 8090
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.49
    Marker Score: 2304
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167597
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.38
    Marker Score: 404
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.38
    Marker Score: 6395
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.35
    Marker Score: 757
  • Cell Name: granule cell (CL0000120)
    Fold Change: 1.34
    Marker Score: 10108
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.33
    Marker Score: 1526
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 1.31
    Marker Score: 3017
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.31
    Marker Score: 691
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 1.31
    Marker Score: 4387
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.31
    Marker Score: 1410
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.3
    Marker Score: 1497
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.3
    Marker Score: 530
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.28
    Marker Score: 538
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.26
    Marker Score: 5253.5
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.25
    Marker Score: 311
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.24
    Marker Score: 2085
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.24
    Marker Score: 311
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.2
    Marker Score: 923
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.18
    Marker Score: 742
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.17
    Marker Score: 1010
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.15
    Marker Score: 29576
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.15
    Marker Score: 560
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.15
    Marker Score: 756
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.13
    Marker Score: 408
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.13
    Marker Score: 2702
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 1.12
    Marker Score: 410
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.12
    Marker Score: 270
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.12
    Marker Score: 653
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.11
    Marker Score: 1226
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.08
    Marker Score: 17376
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.08
    Marker Score: 3537
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.08
    Marker Score: 437
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.08
    Marker Score: 4482
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.07
    Marker Score: 2145
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.07
    Marker Score: 535
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.07
    Marker Score: 416
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.07
    Marker Score: 6884
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.07
    Marker Score: 6504.5
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.07
    Marker Score: 2521
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.05
    Marker Score: 589
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251669
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.04
    Marker Score: 2688
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.03
    Marker Score: 558
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.02
    Marker Score: 330
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.02
    Marker Score: 918
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.02
    Marker Score: 528
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.02
    Marker Score: 591
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 1.02
    Marker Score: 22729
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.01
    Marker Score: 17976
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.01
    Marker Score: 964
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.01
    Marker Score: 379
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71691
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47917
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.99
    Marker Score: 490
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.98
    Marker Score: 269
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.98
    Marker Score: 1389
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30390
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.98
    Marker Score: 362
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.98
    Marker Score: 333
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 0.98
    Marker Score: 543
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.97
    Marker Score: 340
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.97
    Marker Score: 15215
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.97
    Marker Score: 1038
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.97
    Marker Score: 1969
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.96
    Marker Score: 852
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.96
    Marker Score: 4122
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.95
    Marker Score: 2499
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.95
    Marker Score: 251
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.95
    Marker Score: 1280
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.95
    Marker Score: 473
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.95
    Marker Score: 329

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Other Information

**Key characteristics:** - ABL2 is a large protein (135 kDa) with seven immunoglobulin domains. - It is a member of the Src family of tyrosine kinases. - It is activated by various growth factors and cytokines. - It phosphorylates various substrates involved in cell cycle regulation, cell survival, and migration. **Pathways and functions:** - ABL2 is involved in various cellular processes, including cell migration, proliferation, and survival. - It is essential for the development and survival of mammary gland epithelial cells. - It is involved in the regulation of ciliary muscle cells, promoting cell cycle arrest and migration. - It plays a role in the development of the nervous system and the growth and survival of neurons. - It is involved in the regulation of vascular endothelial cells, promoting angiogenesis and tumor growth. **Clinical significance:** - Mutations in ABL2 have been linked to various human cancers, including breast cancer, lung cancer, and colon cancer. - Targeting ABL2 has emerged as a promising therapeutic strategy for these cancers. - ABL2 inhibitors are currently being investigated in clinical trials for the treatment of cancer and other diseases. **Additional information:** - ABL2 is a highly conserved protein, with similar sequences found in mammals and birds. - It is a substrate for various phosphatases, including PI3K, MAPK, and Src. - It is a key regulator of cell growth, proliferation, and survival.

Genular Protein ID: 3014002413

Symbol: ABL2_HUMAN

Name: Tyrosine-protein kinase ABL2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2198571

Title: The complete coding sequence of arg defines the Abelson subfamily of cytoplasmic tyrosine kinases.

PubMed ID: 2198571

DOI: 10.1073/pnas.87.15.5802

PubMed ID: 18810762

Title: Eight full-length abelson related gene (Arg) isoforms are constitutively expressed in caki-1 cell line and cell distribution of two isoforms has been analyzed after transfection.

PubMed ID: 18810762

DOI: 10.1002/jcb.21922

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3787260

Title: A novel human gene closely related to the abl proto-oncogene.

PubMed ID: 3787260

DOI: 10.1126/science.3787260

PubMed ID: 12748290

Title: Two distinct phosphorylation pathways have additive effects on Abl family kinase activation.

PubMed ID: 12748290

DOI: 10.1128/mcb.23.11.3884-3896.2003

PubMed ID: 15886098

Title: RIN1 is an ABL tyrosine kinase activator and a regulator of epithelial-cell adhesion and migration.

PubMed ID: 15886098

DOI: 10.1016/j.cub.2005.03.049

PubMed ID: 15735735

Title: Ubiquitination and degradation of the Arg tyrosine kinase is regulated by oxidative stress.

PubMed ID: 15735735

DOI: 10.1038/sj.onc.1208454

PubMed ID: 16678104

Title: Interaction between c-Abl and Arg tyrosine kinases and proteasome subunit PSMA7 regulates proteasome degradation.

PubMed ID: 16678104

DOI: 10.1016/j.molcel.2006.04.007

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17306540

Title: A critical role for cortactin phosphorylation by Abl-family kinases in PDGF-induced dorsal-wave formation.

PubMed ID: 17306540

DOI: 10.1016/j.cub.2007.01.057

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18945674

Title: Abl kinases regulate autophagy by promoting the trafficking and function of lysosomal components.

PubMed ID: 18945674

DOI: 10.1074/jbc.m804543200

PubMed ID: 12775773

Title: Regulation of F-actin-dependent processes by the Abl family of tyrosine kinases.

PubMed ID: 12775773

DOI: 10.1242/jcs.00622

PubMed ID: 14729179

Title: How do Abl family kinases regulate cell shape and movement?

PubMed ID: 14729179

DOI: 10.1016/j.tcb.2003.11.003

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18182299

Title: Emerging roles of Abl family tyrosine kinases in microbial pathogenesis.

PubMed ID: 18182299

DOI: 10.1016/j.tibs.2007.10.006

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19381274

Title: Unc119 protects from Shigella infection by inhibiting the Abl family kinases.

PubMed ID: 19381274

DOI: 10.1371/journal.pone.0005211

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 20841568

Title: ABL tyrosine kinases: evolution of function, regulation, and specificity.

PubMed ID: 20841568

DOI: 10.1126/scisignal.3139re6

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 21417343

Title: Crystal structures of ABL-related gene (ABL2) in complex with imatinib, tozasertib (VX-680), and a type I inhibitor of the triazole carbothioamide class.

PubMed ID: 21417343

DOI: 10.1021/jm101506n

PubMed ID: 22297987

Title: Lysozyme contamination facilitates crystallization of a heterotrimeric cortactin-Arg-lysozyme complex.

PubMed ID: 22297987

DOI: 10.1107/s1744309111056132

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 1182
  • Mass: 128343
  • Checksum: ED93869BC2B14FAA
  • Sequence:
  • MGQQVGRVGE APGLQQPQPR GIRGSSAARP SGRRRDPAGR TTETGFNIFT QHDHFASCVE 
    DGFEGDKTGG SSPEALHRPY GCDVEPQALN EAIRWSSKEN LLGATESDPN LFVALYDFVA 
    SGDNTLSITK GEKLRVLGYN QNGEWSEVRS KNGQGWVPSN YITPVNSLEK HSWYHGPVSR 
    SAAEYLLSSL INGSFLVRES ESSPGQLSIS LRYEGRVYHY RINTTADGKV YVTAESRFST 
    LAELVHHHST VADGLVTTLH YPAPKCNKPT VYGVSPIHDK WEMERTDITM KHKLGGGQYG 
    EVYVGVWKKY SLTVAVKTLK EDTMEVEEFL KEAAVMKEIK HPNLVQLLGV CTLEPPFYIV 
    TEYMPYGNLL DYLRECNREE VTAVVLLYMA TQISSAMEYL EKKNFIHRDL AARNCLVGEN 
    HVVKVADFGL SRLMTGDTYT AHAGAKFPIK WTAPESLAYN TFSIKSDVWA FGVLLWEIAT 
    YGMSPYPGID LSQVYDLLEK GYRMEQPEGC PPKVYELMRA CWKWSPADRP SFAETHQAFE 
    TMFHDSSISE EVAEELGRAA SSSSVVPYLP RLPILPSKTR TLKKQVENKE NIEGAQDATE 
    NSASSLAPGF IRGAQASSGS PALPRKQRDK SPSSLLEDAK ETCFTRDRKG GFFSSFMKKR 
    NAPTPPKRSS SFREMENQPH KKYELTGNFS SVASLQHADG FSFTPAQQEA NLVPPKCYGG 
    SFAQRNLCND DGGGGGGSGT AGGGWSGITG FFTPRLIKKT LGLRAGKPTA SDDTSKPFPR 
    SNSTSSMSSG LPEQDRMAMT LPRNCQRSKL QLERTVSTSS QPEENVDRAN DMLPKKSEES 
    AAPSRERPKA KLLPRGATAL PLRTPSGDLA ITEKDPPGVG VAGVAAAPKG KEKNGGARLG 
    MAGVPEDGEQ PGWPSPAKAA PVLPTTHNHK VPVLISPTLK HTPADVQLIG TDSQGNKFKL 
    LSEHQVTSSG DKDRPRRVKP KCAPPPPPVM RLLQHPSICS DPTEEPTALT AGQSTSETQE 
    GGKKAALGAV PISGKAGRPV MPPPQVPLPT SSISPAKMAN GTAGTKVALR KTKQAAEKIS 
    ADKISKEALL ECADLLSSAL TEPVPNSQLV DTGHQLLDYC SGYVDCIPQT RNKFAFREAV 
    SKLELSLQEL QVSSAAAGVP GTNPVLNNLL SCVQEISDVV QR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.