Details for: ABL2
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 356.3594
Cell Significance Index: -55.4300 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 211.2809
Cell Significance Index: -53.5900 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 119.2063
Cell Significance Index: -56.2800 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 45.0868
Cell Significance Index: -55.5900 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 20.1728
Cell Significance Index: -54.0400 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 16.1474
Cell Significance Index: -35.3400 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 15.5431
Cell Significance Index: -47.7400 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 14.1154
Cell Significance Index: -55.7000 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 3.7632
Cell Significance Index: 107.8800 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 2.4537
Cell Significance Index: 486.9400 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.1936
Cell Significance Index: 440.0300 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 1.9548
Cell Significance Index: 74.0300 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 1.6657
Cell Significance Index: 73.6800 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.4292
Cell Significance Index: 512.6500 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 1.2778
Cell Significance Index: 883.8000 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 1.1999
Cell Significance Index: 67.3300 - Cell Name: preadipocyte (CL0002334)
Fold Change: 1.1462
Cell Significance Index: 22.3700 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 1.1004
Cell Significance Index: 73.9900 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.8118
Cell Significance Index: 62.3000 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.8115
Cell Significance Index: 732.7100 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 0.7432
Cell Significance Index: 21.2100 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.6726
Cell Significance Index: 17.2900 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.6133
Cell Significance Index: 15.3300 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.5155
Cell Significance Index: 60.0800 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.4526
Cell Significance Index: 282.6200 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.4266
Cell Significance Index: 26.2200 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.3434
Cell Significance Index: 37.3500 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.3009
Cell Significance Index: 57.2700 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.2859
Cell Significance Index: 35.1500 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.2661
Cell Significance Index: 120.7800 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.2474
Cell Significance Index: 4.2400 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.2386
Cell Significance Index: 38.8100 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.1827
Cell Significance Index: 10.9700 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.1496
Cell Significance Index: 26.9700 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.1492
Cell Significance Index: 4.3000 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1285
Cell Significance Index: 12.7100 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.1263
Cell Significance Index: 68.9500 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.1121
Cell Significance Index: 5.2700 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.1076
Cell Significance Index: 202.6100 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0952
Cell Significance Index: 60.4400 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.0717
Cell Significance Index: 1.1100 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0714
Cell Significance Index: 31.5800 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0435
Cell Significance Index: 80.1800 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0380
Cell Significance Index: 58.4900 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0340
Cell Significance Index: 5.8100 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.0324
Cell Significance Index: 0.9100 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.0165
Cell Significance Index: 2.2700 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0129
Cell Significance Index: 17.5300 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -0.0065
Cell Significance Index: -0.4500 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0228
Cell Significance Index: -16.8800 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.0268
Cell Significance Index: -0.5800 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0359
Cell Significance Index: -5.2200 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.0381
Cell Significance Index: -0.2300 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0402
Cell Significance Index: -5.1900 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.0484
Cell Significance Index: -1.0400 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0527
Cell Significance Index: -38.6600 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0548
Cell Significance Index: -30.8800 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0599
Cell Significance Index: -1.6000 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0652
Cell Significance Index: -49.3400 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0940
Cell Significance Index: -4.2600 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1504
Cell Significance Index: -15.3600 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1687
Cell Significance Index: -35.5400 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1690
Cell Significance Index: -48.6200 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.1975
Cell Significance Index: -6.9400 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.2153
Cell Significance Index: -27.6000 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.2264
Cell Significance Index: -5.4300 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.2278
Cell Significance Index: -10.6200 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.2512
Cell Significance Index: -5.5000 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.2949
Cell Significance Index: -2.4100 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.2961
Cell Significance Index: -18.6600 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.3173
Cell Significance Index: -23.6500 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.3279
Cell Significance Index: -37.5700 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.3681
Cell Significance Index: -42.0200 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.3838
Cell Significance Index: -45.2600 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.4314
Cell Significance Index: -44.9200 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: -0.4658
Cell Significance Index: -6.7000 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.4861
Cell Significance Index: -31.3600 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.5035
Cell Significance Index: -35.6100 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.5736
Cell Significance Index: -30.1200 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.6148
Cell Significance Index: -10.8700 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.6190
Cell Significance Index: -49.0300 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.6206
Cell Significance Index: -7.4000 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.6436
Cell Significance Index: -13.3500 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.6465
Cell Significance Index: -10.8900 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.6484
Cell Significance Index: -17.6500 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.6750
Cell Significance Index: -35.1600 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.7780
Cell Significance Index: -40.4100 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.7798
Cell Significance Index: -47.8100 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.7977
Cell Significance Index: -25.5500 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: -0.8119
Cell Significance Index: -10.0700 - Cell Name: decidual cell (CL2000002)
Fold Change: -0.8567
Cell Significance Index: -13.7500 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.8625
Cell Significance Index: -23.1100 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.9123
Cell Significance Index: -29.8700 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.9184
Cell Significance Index: -29.2500 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.9719
Cell Significance Index: -13.2600 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.9771
Cell Significance Index: -20.8100 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -1.0355
Cell Significance Index: -20.7900 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -1.0616
Cell Significance Index: -15.2500 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -1.1396
Cell Significance Index: -16.8200 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -1.1459
Cell Significance Index: -39.8200
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3014002413
Symbol: ABL2_HUMAN
Name: Tyrosine-protein kinase ABL2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2198571
Title: The complete coding sequence of arg defines the Abelson subfamily of cytoplasmic tyrosine kinases.
PubMed ID: 2198571
PubMed ID: 18810762
Title: Eight full-length abelson related gene (Arg) isoforms are constitutively expressed in caki-1 cell line and cell distribution of two isoforms has been analyzed after transfection.
PubMed ID: 18810762
DOI: 10.1002/jcb.21922
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 17974005
Title: The full-ORF clone resource of the German cDNA consortium.
PubMed ID: 17974005
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 3787260
Title: A novel human gene closely related to the abl proto-oncogene.
PubMed ID: 3787260
PubMed ID: 12748290
Title: Two distinct phosphorylation pathways have additive effects on Abl family kinase activation.
PubMed ID: 12748290
PubMed ID: 15886098
Title: RIN1 is an ABL tyrosine kinase activator and a regulator of epithelial-cell adhesion and migration.
PubMed ID: 15886098
PubMed ID: 15735735
Title: Ubiquitination and degradation of the Arg tyrosine kinase is regulated by oxidative stress.
PubMed ID: 15735735
PubMed ID: 16678104
Title: Interaction between c-Abl and Arg tyrosine kinases and proteasome subunit PSMA7 regulates proteasome degradation.
PubMed ID: 16678104
PubMed ID: 16964243
Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
PubMed ID: 16964243
DOI: 10.1038/nbt1240
PubMed ID: 17306540
Title: A critical role for cortactin phosphorylation by Abl-family kinases in PDGF-induced dorsal-wave formation.
PubMed ID: 17306540
PubMed ID: 17525332
Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
PubMed ID: 17525332
PubMed ID: 18945674
Title: Abl kinases regulate autophagy by promoting the trafficking and function of lysosomal components.
PubMed ID: 18945674
PubMed ID: 12775773
Title: Regulation of F-actin-dependent processes by the Abl family of tyrosine kinases.
PubMed ID: 12775773
DOI: 10.1242/jcs.00622
PubMed ID: 14729179
Title: How do Abl family kinases regulate cell shape and movement?
PubMed ID: 14729179
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 18182299
Title: Emerging roles of Abl family tyrosine kinases in microbial pathogenesis.
PubMed ID: 18182299
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19369195
Title: Large-scale proteomics analysis of the human kinome.
PubMed ID: 19369195
PubMed ID: 19381274
Title: Unc119 protects from Shigella infection by inhibiting the Abl family kinases.
PubMed ID: 19381274
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 20841568
Title: ABL tyrosine kinases: evolution of function, regulation, and specificity.
PubMed ID: 20841568
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 21417343
Title: Crystal structures of ABL-related gene (ABL2) in complex with imatinib, tozasertib (VX-680), and a type I inhibitor of the triazole carbothioamide class.
PubMed ID: 21417343
DOI: 10.1021/jm101506n
PubMed ID: 22297987
Title: Lysozyme contamination facilitates crystallization of a heterotrimeric cortactin-Arg-lysozyme complex.
PubMed ID: 22297987
PubMed ID: 17344846
Title: Patterns of somatic mutation in human cancer genomes.
PubMed ID: 17344846
DOI: 10.1038/nature05610
Sequence Information:
- Length: 1182
- Mass: 128343
- Checksum: ED93869BC2B14FAA
- Sequence:
MGQQVGRVGE APGLQQPQPR GIRGSSAARP SGRRRDPAGR TTETGFNIFT QHDHFASCVE DGFEGDKTGG SSPEALHRPY GCDVEPQALN EAIRWSSKEN LLGATESDPN LFVALYDFVA SGDNTLSITK GEKLRVLGYN QNGEWSEVRS KNGQGWVPSN YITPVNSLEK HSWYHGPVSR SAAEYLLSSL INGSFLVRES ESSPGQLSIS LRYEGRVYHY RINTTADGKV YVTAESRFST LAELVHHHST VADGLVTTLH YPAPKCNKPT VYGVSPIHDK WEMERTDITM KHKLGGGQYG EVYVGVWKKY SLTVAVKTLK EDTMEVEEFL KEAAVMKEIK HPNLVQLLGV CTLEPPFYIV TEYMPYGNLL DYLRECNREE VTAVVLLYMA TQISSAMEYL EKKNFIHRDL AARNCLVGEN HVVKVADFGL SRLMTGDTYT AHAGAKFPIK WTAPESLAYN TFSIKSDVWA FGVLLWEIAT YGMSPYPGID LSQVYDLLEK GYRMEQPEGC PPKVYELMRA CWKWSPADRP SFAETHQAFE TMFHDSSISE EVAEELGRAA SSSSVVPYLP RLPILPSKTR TLKKQVENKE NIEGAQDATE NSASSLAPGF IRGAQASSGS PALPRKQRDK SPSSLLEDAK ETCFTRDRKG GFFSSFMKKR NAPTPPKRSS SFREMENQPH KKYELTGNFS SVASLQHADG FSFTPAQQEA NLVPPKCYGG SFAQRNLCND DGGGGGGSGT AGGGWSGITG FFTPRLIKKT LGLRAGKPTA SDDTSKPFPR SNSTSSMSSG LPEQDRMAMT LPRNCQRSKL QLERTVSTSS QPEENVDRAN DMLPKKSEES AAPSRERPKA KLLPRGATAL PLRTPSGDLA ITEKDPPGVG VAGVAAAPKG KEKNGGARLG MAGVPEDGEQ PGWPSPAKAA PVLPTTHNHK VPVLISPTLK HTPADVQLIG TDSQGNKFKL LSEHQVTSSG DKDRPRRVKP KCAPPPPPVM RLLQHPSICS DPTEEPTALT AGQSTSETQE GGKKAALGAV PISGKAGRPV MPPPQVPLPT SSISPAKMAN GTAGTKVALR KTKQAAEKIS ADKISKEALL ECADLLSSAL TEPVPNSQLV DTGHQLLDYC SGYVDCIPQT RNKFAFREAV SKLELSLQEL QVSSAAAGVP GTNPVLNNLL SCVQEISDVV QR
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.