ABL2 - ENSG00000143322

Details for: ABL2

Gene ID: 27

Symbol: ABL2

Ensembl ID: ENSG00000143322

Description: ABL proto-oncogene 2, non-receptor tyrosine kinase

Associated with

Axon guidance (R-HSA-422475)
Cytokine signaling in immune system (R-HSA-1280215)
Developmental biology (R-HSA-1266738)
Flt3 signaling (R-HSA-9607240)
Immune system (R-HSA-168256)
Negative regulation of flt3 (R-HSA-9706369)
Nervous system development (R-HSA-9675108)
Rac1 gtpase cycle (R-HSA-9013149)
Rac3 gtpase cycle (R-HSA-9013423)
Rho gtpase cycle (R-HSA-9012999)
Role of abl in robo-slit signaling (R-HSA-428890)
Signaling by rho gtpases (R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3 (R-HSA-9716542)
Signaling by robo receptors (R-HSA-376176)
Actin cytoskeleton (GO:0015629)
Actin filament binding (GO:0051015)
Actin monomer binding (GO:0003785)
Atp binding (GO:0005524)
Cell adhesion (GO:0007155)
Cellular response to retinoic acid (GO:0071300)
Cytosol (GO:0005829)
Epidermal growth factor receptor signaling pathway (GO:0007173)
Exploration behavior (GO:0035640)
Magnesium ion binding (GO:0000287)
Manganese ion binding (GO:0030145)
Negative regulation of rho protein signal transduction (GO:0035024)
Non-membrane spanning protein tyrosine kinase activity (GO:0004715)
Peptidyl-tyrosine phosphorylation (GO:0018108)
Phosphotyrosine residue binding (GO:0001784)
Positive regulation of cytosolic calcium ion concentration (GO:0007204)
Positive regulation of establishment of t cell polarity (GO:1903905)
Positive regulation of neuron projection development (GO:0010976)
Positive regulation of oxidoreductase activity (GO:0051353)
Positive regulation of phospholipase c activity (GO:0010863)
Positive regulation of t cell migration (GO:2000406)
Protein binding (GO:0005515)
Protein kinase activity (GO:0004672)
Protein modification process (GO:0036211)
Protein phosphorylation (GO:0006468)
Protein tyrosine kinase activity (GO:0004713)
Regulation of actin cytoskeleton organization (GO:0032956)
Regulation of autophagy (GO:0010506)
Regulation of cell adhesion (GO:0030155)
Regulation of cell motility (GO:2000145)
Regulation of endocytosis (GO:0030100)
Signal transduction (GO:0007165)

Cells (max top 100)

Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 2.86
Marker Score: 97368
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 2.28
Marker Score: 5004
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 2.14
Marker Score: 81454
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 2.04
Marker Score: 15631
Cell Name: cardiac neuron (CL0010022)
Fold Change: 2.01
Marker Score: 2501
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.9
Marker Score: 117119
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 1.89
Marker Score: 17754
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 1.87
Marker Score: 2719
Cell Name: neuron (CL0000540)
Fold Change: 1.87
Marker Score: 7616.5
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 1.85
Marker Score: 27604
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.81
Marker Score: 7001
Cell Name: fibroblast of breast (CL4006000)
Fold Change: 1.8
Marker Score: 1024
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.78
Marker Score: 16916
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 1.76
Marker Score: 37640
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.73
Marker Score: 14826
Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 1.7
Marker Score: 4848
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 1.69
Marker Score: 7012
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 1.68
Marker Score: 61903
Cell Name: Purkinje cell (CL0000121)
Fold Change: 1.65
Marker Score: 55670
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 1.62
Marker Score: 32226
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.62
Marker Score: 16707
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 1.58
Marker Score: 3040
Cell Name: photoreceptor cell (CL0000210)
Fold Change: 1.53
Marker Score: 1155
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 1.53
Marker Score: 912
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 1.53
Marker Score: 635
Cell Name: subcutaneous fat cell (CL0002521)
Fold Change: 1.52
Marker Score: 557
Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
Fold Change: 1.51
Marker Score: 7932
Cell Name: stellate neuron (CL0000122)
Fold Change: 1.51
Marker Score: 8090
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.49
Marker Score: 2304
Cell Name: mural cell (CL0008034)
Fold Change: 1.46
Marker Score: 167597
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 1.38
Marker Score: 404
Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 1.38
Marker Score: 6395
Cell Name: fat cell (CL0000136)
Fold Change: 1.35
Marker Score: 757
Cell Name: granule cell (CL0000120)
Fold Change: 1.34
Marker Score: 10108
Cell Name: lung macrophage (CL1001603)
Fold Change: 1.33
Marker Score: 1526
Cell Name: macroglial cell (CL0000126)
Fold Change: 1.31
Marker Score: 3017
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 1.31
Marker Score: 691
Cell Name: neuronal brush cell (CL0000555)
Fold Change: 1.31
Marker Score: 4387
Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 1.31
Marker Score: 1410
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 1.3
Marker Score: 1497
Cell Name: eurydendroid cell (CL0000253)
Fold Change: 1.3
Marker Score: 530
Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 1.28
Marker Score: 538
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 1.26
Marker Score: 5253.5
Cell Name: fibroblast of connective tissue of prostate (CL1000299)
Fold Change: 1.25
Marker Score: 311
Cell Name: pyramidal neuron (CL0000598)
Fold Change: 1.24
Marker Score: 2085
Cell Name: prostate stromal cell (CL0002622)
Fold Change: 1.24
Marker Score: 311
Cell Name: renal principal cell (CL0005009)
Fold Change: 1.2
Marker Score: 923
Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 1.18
Marker Score: 742
Cell Name: taste receptor cell (CL0000209)
Fold Change: 1.17
Marker Score: 1010
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 1.15
Marker Score: 29576
Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 1.15
Marker Score: 560
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 1.15
Marker Score: 756
Cell Name: mature microglial cell (CL0002629)
Fold Change: 1.13
Marker Score: 408
Cell Name: oligodendrocyte (CL0000128)
Fold Change: 1.13
Marker Score: 2702
Cell Name: reticular cell (CL0000432)
Fold Change: 1.12
Marker Score: 410
Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: 1.12
Marker Score: 270
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 1.12
Marker Score: 653
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 1.11
Marker Score: 1226
Cell Name: lactocyte (CL0002325)
Fold Change: 1.08
Marker Score: 17376
Cell Name: hepatoblast (CL0005026)
Fold Change: 1.08
Marker Score: 3537
Cell Name: melanocyte (CL0000148)
Fold Change: 1.08
Marker Score: 437
Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 1.08
Marker Score: 4482
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 1.07
Marker Score: 2145
Cell Name: osteoclast (CL0000092)
Fold Change: 1.07
Marker Score: 535
Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 1.07
Marker Score: 416
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 1.07
Marker Score: 6884
Cell Name: elicited macrophage (CL0000861)
Fold Change: 1.07
Marker Score: 6504.5
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 1.07
Marker Score: 2521
Cell Name: cerebellar granule cell precursor (CL0002362)
Fold Change: 1.05
Marker Score: 589
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.04
Marker Score: 251669
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 1.04
Marker Score: 2688
Cell Name: contractile cell (CL0000183)
Fold Change: 1.03
Marker Score: 558
Cell Name: mononuclear cell (CL0000842)
Fold Change: 1.02
Marker Score: 330
Cell Name: endothelial cell (CL0000115)
Fold Change: 1.02
Marker Score: 918
Cell Name: endocrine cell (CL0000163)
Fold Change: 1.02
Marker Score: 528
Cell Name: brainstem motor neuron (CL2000047)
Fold Change: 1.02
Marker Score: 591
Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 1.02
Marker Score: 22729
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 1.01
Marker Score: 17976
Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 1.01
Marker Score: 964
Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 1.01
Marker Score: 379
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71691
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 47917
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.99
Marker Score: 490
Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 0.98
Marker Score: 269
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 0.98
Marker Score: 1389
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30390
Cell Name: podocyte (CL0000653)
Fold Change: 0.98
Marker Score: 362
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.98
Marker Score: 333
Cell Name: alveolar type 2 fibroblast cell (CL4028006)
Fold Change: 0.98
Marker Score: 543
Cell Name: ependymal cell (CL0000065)
Fold Change: 0.97
Marker Score: 340
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.97
Marker Score: 15215
Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 0.97
Marker Score: 1038
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.97
Marker Score: 1969
Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 0.96
Marker Score: 852
Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 0.96
Marker Score: 4122
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 0.95
Marker Score: 2499
Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
Fold Change: 0.95
Marker Score: 251
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.95
Marker Score: 1280
Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 0.95
Marker Score: 473
Cell Name: Schwann cell (CL0002573)
Fold Change: 0.95
Marker Score: 329

**Key characteristics:** - ABL2 is a large protein (135 kDa) with seven immunoglobulin domains. - It is a member of the Src family of tyrosine kinases. - It is activated by various growth factors and cytokines. - It phosphorylates various substrates involved in cell cycle regulation, cell survival, and migration. **Pathways and functions:** - ABL2 is involved in various cellular processes, including cell migration, proliferation, and survival. - It is essential for the development and survival of mammary gland epithelial cells. - It is involved in the regulation of ciliary muscle cells, promoting cell cycle arrest and migration. - It plays a role in the development of the nervous system and the growth and survival of neurons. - It is involved in the regulation of vascular endothelial cells, promoting angiogenesis and tumor growth. **Clinical significance:** - Mutations in ABL2 have been linked to various human cancers, including breast cancer, lung cancer, and colon cancer. - Targeting ABL2 has emerged as a promising therapeutic strategy for these cancers. - ABL2 inhibitors are currently being investigated in clinical trials for the treatment of cancer and other diseases. **Additional information:** - ABL2 is a highly conserved protein, with similar sequences found in mammals and birds. - It is a substrate for various phosphatases, including PI3K, MAPK, and Src. - It is a key regulator of cell growth, proliferation, and survival.

Database document:

Only first 5 entries are kept for 'singleCellExpressions', 'mRNAExpressions' and other large data arrays.