Details for: SLC25A5

Gene ID: 292

Symbol: SLC25A5

Ensembl ID: ENSG00000005022

Description: solute carrier family 25 member 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 513.7413
    Cell Significance Index: -79.9100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 261.7566
    Cell Significance Index: -107.8300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 257.6649
    Cell Significance Index: -65.3600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 229.0506
    Cell Significance Index: -108.1400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 212.0395
    Cell Significance Index: -109.0700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 160.7697
    Cell Significance Index: -107.8800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 82.4360
    Cell Significance Index: -101.6400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 27.5440
    Cell Significance Index: -84.6000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 27.2450
    Cell Significance Index: -107.5100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 22.8343
    Cell Significance Index: -61.1700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 5.6002
    Cell Significance Index: 660.4300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 5.0216
    Cell Significance Index: 147.4800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 4.9743
    Cell Significance Index: 130.8000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 4.7236
    Cell Significance Index: 334.0700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 4.3526
    Cell Significance Index: 280.8100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 4.3357
    Cell Significance Index: 203.7800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.8681
    Cell Significance Index: 180.3500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 3.5051
    Cell Significance Index: 1549.6900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 3.4749
    Cell Significance Index: 427.2700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 3.4167
    Cell Significance Index: 615.9300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 3.3515
    Cell Significance Index: 433.0000
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 3.2817
    Cell Significance Index: 28.2000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 3.1682
    Cell Significance Index: 29.1800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.9930
    Cell Significance Index: 1634.5300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.6279
    Cell Significance Index: 75.3300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.6274
    Cell Significance Index: 195.8200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 2.4977
    Cell Significance Index: 426.5000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.1797
    Cell Significance Index: 299.3400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.0678
    Cell Significance Index: 36.5400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.8855
    Cell Significance Index: 21.4200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.7984
    Cell Significance Index: 48.9500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.7837
    Cell Significance Index: 176.4500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.5193
    Cell Significance Index: 28.0800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.4849
    Cell Significance Index: 32.1700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.3905
    Cell Significance Index: 72.2300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.3569
    Cell Significance Index: 47.1500
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.2284
    Cell Significance Index: 28.3800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.1925
    Cell Significance Index: 62.6100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.0064
    Cell Significance Index: 8.0400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.9555
    Cell Significance Index: 20.0000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.8766
    Cell Significance Index: 9.5300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.8677
    Cell Significance Index: 54.6900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.8565
    Cell Significance Index: 22.8700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.7877
    Cell Significance Index: 9.3900
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.6787
    Cell Significance Index: 5.1300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.6598
    Cell Significance Index: 499.4400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6558
    Cell Significance Index: 130.1500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.6263
    Cell Significance Index: 459.2000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5261
    Cell Significance Index: 67.4400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 0.5246
    Cell Significance Index: 41.5500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5125
    Cell Significance Index: 97.5300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.4746
    Cell Significance Index: 12.7000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.2104
    Cell Significance Index: 2.7000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0696
    Cell Significance Index: 20.0300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0400
    Cell Significance Index: 1.2800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0339
    Cell Significance Index: 1.1900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0088
    Cell Significance Index: -6.4900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0100
    Cell Significance Index: -1.0200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0391
    Cell Significance Index: -7.8500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0485
    Cell Significance Index: -91.2800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0553
    Cell Significance Index: -34.5400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0603
    Cell Significance Index: -111.2500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0740
    Cell Significance Index: -113.9900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0857
    Cell Significance Index: -116.5100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1230
    Cell Significance Index: -69.3800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.1395
    Cell Significance Index: -50.0300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1439
    Cell Significance Index: -16.4300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1529
    Cell Significance Index: -97.1100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.1934
    Cell Significance Index: -31.4600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1955
    Cell Significance Index: -2.9300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1987
    Cell Significance Index: -41.8500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.2206
    Cell Significance Index: -100.1200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2729
    Cell Significance Index: -12.3700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2987
    Cell Significance Index: -7.6300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4301
    Cell Significance Index: -49.2700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.5785
    Cell Significance Index: -40.0100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.5890
    Cell Significance Index: -16.4600
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.5907
    Cell Significance Index: -3.6300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.6329
    Cell Significance Index: -73.7600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.7011
    Cell Significance Index: -101.9100
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.7106
    Cell Significance Index: -14.8200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.9297
    Cell Significance Index: -15.5600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.0144
    Cell Significance Index: -13.8400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.0228
    Cell Significance Index: -106.5000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -1.0674
    Cell Significance Index: -11.0500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.1697
    Cell Significance Index: -89.7600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -1.2108
    Cell Significance Index: -74.4200
  • Cell Name: centroblast (CL0009112)
    Fold Change: -1.3202
    Cell Significance Index: -3.0800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -1.3854
    Cell Significance Index: -83.1700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.4004
    Cell Significance Index: -29.8300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.4085
    Cell Significance Index: -79.0400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.4191
    Cell Significance Index: -41.8000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -1.4238
    Cell Significance Index: -58.3400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.4513
    Cell Significance Index: -88.9800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.5217
    Cell Significance Index: -102.3200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -1.5658
    Cell Significance Index: -9.4600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.8501
    Cell Significance Index: -49.5800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -2.1265
    Cell Significance Index: -107.4700
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -2.2239
    Cell Significance Index: -18.6800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -2.4095
    Cell Significance Index: -106.5800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Mitochondrial localization**: SLC25A5 is a mitochondrial transporter protein, which suggests its role in regulating mitochondrial function and energy metabolism. 2. **Adenosine triphosphate (ATP) and adenosine diphosphate (ADP) transport**: The protein is responsible for transporting ATP and ADP across the mitochondrial membrane, playing a crucial role in regulating energy metabolism and maintaining mitochondrial function. 3. **Multiple isoforms**: The SLC25A5 gene encodes multiple isoforms, including ADT2_HUMAN, which is the N-terminally processed form of the protein. 4. **Tissue-specific expression**: SLC25A5 is expressed in multiple cell types, including hematopoietic stem cells, epithelial cells, and renal intercalated cells. **Pathways and Functions** 1. **Adaptive thermogenesis**: SLC25A5 plays a crucial role in regulating energy metabolism and maintaining mitochondrial function, which is essential for adaptive thermogenesis. 2. **Cell differentiation**: The protein is involved in regulating cell differentiation, particularly in hematopoietic stem cells and epithelial cells. 3. **Immune responses**: SLC25A5 is implicated in immune responses, particularly in the regulation of B cell differentiation and the response to HIV infection. 4. **Mitochondrial function**: The protein regulates mitochondrial function, including mitochondrial membrane permeability and protein degradation. 5. **Energy metabolism**: SLC25A5 plays a crucial role in regulating energy metabolism, particularly in the transport of ATP and ADP across the mitochondrial membrane. **Clinical Significance** 1. **Energy metabolism disorders**: Abnormalities in SLC25A5 function may contribute to energy metabolism disorders, such as mitochondrial myopathies. 2. **Cancer**: The protein's role in regulating cell differentiation and immune responses may contribute to cancer development and progression. 3. **HIV infection**: SLC25A5 is implicated in the response to HIV infection, particularly in the regulation of B cell differentiation and the induction of apoptosis. 4. **Thermogenesis**: The protein's role in regulating adaptive thermogenesis may have implications for the treatment of metabolic disorders, such as obesity and type 2 diabetes. In conclusion, SLC25A5 is a crucial gene involved in various cellular processes, including energy metabolism, cell differentiation, and immune responses. Further research is needed to fully understand the role of this gene in human health and disease.

Genular Protein ID: 384711319

Symbol: ADT2_HUMAN

Name: ADP/ATP translocase 2, N-terminally processed

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2168878

Title: The human fibroblast adenine nucleotide translocator gene. Molecular cloning and sequence.

PubMed ID: 2168878

DOI: 10.1016/s0021-9258(17)46187-4

PubMed ID: 3031073

Title: Molecular cloning of a cDNA for a human ADP/ATP carrier which is growth-regulated.

PubMed ID: 3031073

DOI: 10.1016/s0021-9258(18)61355-9

PubMed ID: 8918809

Title: Ordered shotgun sequencing of a 135 kb Xq25 YAC containing ANT2 and four possible genes, including three confirmed by EST matches.

PubMed ID: 8918809

DOI: 10.1093/nar/24.20.4034

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2829183

Title: Two distinct genes for ADP/ATP translocase are expressed at the mRNA level in adult human liver.

PubMed ID: 2829183

DOI: 10.1073/pnas.85.2.377

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 16120388

Title: Mitochondrial membrane permeabilization by HIV-1 Vpr.

PubMed ID: 16120388

DOI: 10.1016/j.mito.2004.06.012

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19130895

Title: Enzymatically inactive adenylate kinase 4 interacts with mitochondrial ADP/ATP translocase.

PubMed ID: 19130895

DOI: 10.1016/j.biocel.2008.12.002

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20797633

Title: MMXD, a TFIIH-independent XPD-MMS19 protein complex involved in chromosome segregation.

PubMed ID: 20797633

DOI: 10.1016/j.molcel.2010.07.029

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21908771

Title: The first identification of lysine malonylation substrates and its regulatory enzyme.

PubMed ID: 21908771

DOI: 10.1074/mcp.m111.012658

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27641616

Title: TSPO ligands stimulate ZnPPIX transport and ROS accumulation leading to the inhibition of P. falciparum growth in human blood.

PubMed ID: 27641616

DOI: 10.1038/srep33516

PubMed ID: 31213526

Title: Human FAM173A is a mitochondrial lysine-specific methyltransferase that targets adenine nucleotide translocase and affects mitochondrial respiration.

PubMed ID: 31213526

DOI: 10.1074/jbc.ra119.009045

PubMed ID: 31883789

Title: Human-specific ARHGAP11B acts in mitochondria to expand neocortical progenitors by glutaminolysis.

PubMed ID: 31883789

DOI: 10.1016/j.neuron.2019.11.027

Sequence Information:

  • Length: 298
  • Mass: 32852
  • Checksum: DC53D083E7217AFE
  • Sequence:
  • MTDAAVSFAK DFLAGGVAAA ISKTAVAPIE RVKLLLQVQH ASKQITADKQ YKGIIDCVVR 
    IPKEQGVLSF WRGNLANVIR YFPTQALNFA FKDKYKQIFL GGVDKRTQFW LYFAGNLASG 
    GAAGATSLCF VYPLDFARTR LAADVGKAGA EREFRGLGDC LVKIYKSDGI KGLYQGFNVS 
    VQGIIIYRAA YFGIYDTAKG MLPDPKNTHI VISWMIAQTV TAVAGLTSYP FDTVRRRMMM 
    QSGRKGTDIM YTGTLDCWRK IARDEGGKAF FKGAWSNVLR GMGGAFVLVL YDEIKKYT

Genular Protein ID: 1579327599

Symbol: Q6NVC0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 323
  • Mass: 35294
  • Checksum: 2169F1DD822DC5EC
  • Sequence:
  • GARSAGVKAG SRPSPVLQQS ASSFNMTDAA VSFAKDFLAG GVAAAISKTA VAPIERVKLL 
    LQVQHASKQI TADKQYKGII DCVVRIPKEQ GVLSFWRGNL ANVIRYFPTQ ALNFAFKDKY 
    KQIFLGGVDK RTQFWLYFAG NLASGGAAGA TSLCFVYPLD FARTRLAADV GKAGAEREFR 
    GLGDCLVKIY KSDGIKGLYQ GFNVSVQGII IYRAAYFGIY DTAKGMLPDP KNTHIVISWM 
    IAQTVTAVAG LTSYPFDTVR RRMMMQSGRK GTDIMYTGTL DCWRKIARDE GGKAFFKGAW 
    SNVLRGMGGA FVLVLYDEIK KYT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.