Details for: SLC25A5

Gene ID: 292

Symbol: SLC25A5

Ensembl ID: ENSG00000005022

Description: solute carrier family 25 member 5

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 6.1
    Marker Score: 4601
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 3.74
    Marker Score: 27825
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 3.71
    Marker Score: 1980
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 3.5
    Marker Score: 11005
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.48
    Marker Score: 8493
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 3.47
    Marker Score: 9294
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 3.41
    Marker Score: 45782
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 3.37
    Marker Score: 21972.5
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 3.37
    Marker Score: 2051
  • Cell Name: blood cell (CL0000081)
    Fold Change: 3.23
    Marker Score: 37531
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.21
    Marker Score: 109303
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 3.21
    Marker Score: 5325
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 3.18
    Marker Score: 4495
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 3.12
    Marker Score: 1028
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 3.12
    Marker Score: 30908
  • Cell Name: centroblast (CL0009112)
    Fold Change: 3.11
    Marker Score: 1533
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 3.07
    Marker Score: 14749
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.07
    Marker Score: 171705
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 3.03
    Marker Score: 5536
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 3.03
    Marker Score: 8989
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 3.02
    Marker Score: 5402.5
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 3.02
    Marker Score: 4805
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 3.02
    Marker Score: 2379
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 3.01
    Marker Score: 3141.5
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 3
    Marker Score: 10652
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.99
    Marker Score: 23363
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.93
    Marker Score: 5715
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.88
    Marker Score: 6562
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.87
    Marker Score: 5011
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.85
    Marker Score: 3262
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.84
    Marker Score: 3033
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.84
    Marker Score: 18094
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 2.8
    Marker Score: 2679
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 2.78
    Marker Score: 2613
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.78
    Marker Score: 11372
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.78
    Marker Score: 6305
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 2.77
    Marker Score: 885
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.75
    Marker Score: 27898
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.74
    Marker Score: 4410
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.73
    Marker Score: 7550
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 2.73
    Marker Score: 3220
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.72
    Marker Score: 94214.5
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 2.72
    Marker Score: 2133.5
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 2.71
    Marker Score: 2421.5
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.71
    Marker Score: 2711
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.71
    Marker Score: 17296
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 2.7
    Marker Score: 14204
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.67
    Marker Score: 10313
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 2.67
    Marker Score: 2630
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 2.65
    Marker Score: 1758
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 2.64
    Marker Score: 7530
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 2.63
    Marker Score: 4052
  • Cell Name: basal cell (CL0000646)
    Fold Change: 2.61
    Marker Score: 3375
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.61
    Marker Score: 66936
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.61
    Marker Score: 22503
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 2.61
    Marker Score: 6753.5
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.6
    Marker Score: 4265
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 2.6
    Marker Score: 6272
  • Cell Name: club cell (CL0000158)
    Fold Change: 2.6
    Marker Score: 3032
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 2.59
    Marker Score: 11125
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.59
    Marker Score: 1625
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 2.58
    Marker Score: 875
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.58
    Marker Score: 16767
  • Cell Name: Unknown (CL0000548)
    Fold Change: 2.58
    Marker Score: 1878
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.57
    Marker Score: 136106
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 2.57
    Marker Score: 7500
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.57
    Marker Score: 33867
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.56
    Marker Score: 612
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 2.56
    Marker Score: 1540
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.55
    Marker Score: 4795
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.54
    Marker Score: 6412
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 2.54
    Marker Score: 2560
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 2.52
    Marker Score: 1478
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.52
    Marker Score: 6864
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 2.52
    Marker Score: 1325
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 2.5
    Marker Score: 5246
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 2.5
    Marker Score: 921.5
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 2.5
    Marker Score: 7880
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 2.48
    Marker Score: 2399
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 2.48
    Marker Score: 1791
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.48
    Marker Score: 2330
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 2.48
    Marker Score: 2625
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 2.47
    Marker Score: 3807.5
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 2.47
    Marker Score: 14661
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.47
    Marker Score: 1029
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 2.47
    Marker Score: 1025
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 2.46
    Marker Score: 1865
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 2.46
    Marker Score: 870
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.45
    Marker Score: 1224
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 2.45
    Marker Score: 2181.5
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.44
    Marker Score: 2611
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 2.44
    Marker Score: 1769
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 2.44
    Marker Score: 1108
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 2.43
    Marker Score: 5929
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.43
    Marker Score: 5717
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 2.42
    Marker Score: 2156
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.42
    Marker Score: 2459
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 2.42
    Marker Score: 6799
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 2.42
    Marker Score: 584
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 2.42
    Marker Score: 2334

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** * The SLC25A5 protein is a transmembrane protein that is expressed in the plasma membrane. * It is a multi-pass protein that is composed of 14 transmembrane domains. * The protein is responsible for the transport of a variety of molecules, including nucleotides, amino acids, and proteins. **Pathways and functions:** * The SLC25A5 protein is involved in the transport of nucleosides and free purine and pyrimidine bases across the plasma membrane. * It is also involved in the transport of small molecules, including amino acids, proteins, and lipids. * The protein is also involved in the transport of vitamins and other molecules between the cell and the extracellular environment. **Clinical significance:** * Mutations in the SLC25A5 gene have been linked to a number of human diseases, including HIV infection, cancer, and cardiovascular disease. * The SLC25A5 protein is a potential target for therapy in these diseases. **Additional information:** * The SLC25A5 gene is located on chromosome 15q21.1. * The protein is expressed in high levels in normal tissues, but its expression is increased in cancer cells. * The SLC25A5 protein is a promising target for cancer immunotherapy.

Genular Protein ID: 384711319

Symbol: ADT2_HUMAN

Name: ADP/ATP translocase 2, N-terminally processed

UniProtKB Accession Codes:

P05141 B2RCV1 O43350

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChEBI 6 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 DrugCentral 1 EMBL 7 EPD 1 Ensembl 1 GO 27 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 MoonProt 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRIDE 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 5 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2168878

Title: The human fibroblast adenine nucleotide translocator gene. Molecular cloning and sequence.

PubMed ID: 2168878

DOI: 10.1016/s0021-9258(17)46187-4

PubMed ID: 3031073

Title: Molecular cloning of a cDNA for a human ADP/ATP carrier which is growth-regulated.

PubMed ID: 3031073

DOI: 10.1016/s0021-9258(18)61355-9

PubMed ID: 8918809

Title: Ordered shotgun sequencing of a 135 kb Xq25 YAC containing ANT2 and four possible genes, including three confirmed by EST matches.

PubMed ID: 8918809

DOI: 10.1093/nar/24.20.4034

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2829183

Title: Two distinct genes for ADP/ATP translocase are expressed at the mRNA level in adult human liver.

PubMed ID: 2829183

DOI: 10.1073/pnas.85.2.377

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 16120388

Title: Mitochondrial membrane permeabilization by HIV-1 Vpr.

PubMed ID: 16120388

DOI: 10.1016/j.mito.2004.06.012

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19130895

Title: Enzymatically inactive adenylate kinase 4 interacts with mitochondrial ADP/ATP translocase.

PubMed ID: 19130895

DOI: 10.1016/j.biocel.2008.12.002

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20797633

Title: MMXD, a TFIIH-independent XPD-MMS19 protein complex involved in chromosome segregation.

PubMed ID: 20797633

DOI: 10.1016/j.molcel.2010.07.029

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21908771

Title: The first identification of lysine malonylation substrates and its regulatory enzyme.

PubMed ID: 21908771

DOI: 10.1074/mcp.m111.012658

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27641616

Title: TSPO ligands stimulate ZnPPIX transport and ROS accumulation leading to the inhibition of P. falciparum growth in human blood.

PubMed ID: 27641616

DOI: 10.1038/srep33516

PubMed ID: 31213526

Title: Human FAM173A is a mitochondrial lysine-specific methyltransferase that targets adenine nucleotide translocase and affects mitochondrial respiration.

PubMed ID: 31213526

DOI: 10.1074/jbc.ra119.009045

PubMed ID: 31883789

Title: Human-specific ARHGAP11B acts in mitochondria to expand neocortical progenitors by glutaminolysis.

PubMed ID: 31883789

DOI: 10.1016/j.neuron.2019.11.027

Sequence Information:

  • Length: 298
  • Mass: 32852
  • Checksum: DC53D083E7217AFE
  • Sequence:
    • MTDAAVSFAK DFLAGGVAAA ISKTAVAPIE RVKLLLQVQH ASKQITADKQ YKGIIDCVVR 
IPKEQGVLSF WRGNLANVIR YFPTQALNFA FKDKYKQIFL GGVDKRTQFW LYFAGNLASG 
GAAGATSLCF VYPLDFARTR LAADVGKAGA EREFRGLGDC LVKIYKSDGI KGLYQGFNVS 
VQGIIIYRAA YFGIYDTAKG MLPDPKNTHI VISWMIAQTV TAVAGLTSYP FDTVRRRMMM 
QSGRKGTDIM YTGTLDCWRK IARDEGGKAF FKGAWSNVLR GMGGAFVLVL YDEIKKYT

Genular Protein ID: 1579327599

Symbol: Q6NVC0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6NVC0

Database IDs:

ARBA 12 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChEBI 3 ChiTaRS 1 DNASU 1 EMBL 2 GO 4 Gene3D 1 Genevisible 1 GenomeRNAi 1 IntAct 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 1 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 Rhea 2 RuleBase 2 SMR 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 323
  • Mass: 35294
  • Checksum: 2169F1DD822DC5EC
  • Sequence:
    • GARSAGVKAG SRPSPVLQQS ASSFNMTDAA VSFAKDFLAG GVAAAISKTA VAPIERVKLL 
LQVQHASKQI TADKQYKGII DCVVRIPKEQ GVLSFWRGNL ANVIRYFPTQ ALNFAFKDKY 
KQIFLGGVDK RTQFWLYFAG NLASGGAAGA TSLCFVYPLD FARTRLAADV GKAGAEREFR 
GLGDCLVKIY KSDGIKGLYQ GFNVSVQGII IYRAAYFGIY DTAKGMLPDP KNTHIVISWM 
IAQTVTAVAG LTSYPFDTVR RRMMMQSGRK GTDIMYTGTL DCWRKIARDE GGKAFFKGAW 
SNVLRGMGGA FVLVLYDEIK KYT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.